Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.007 0.116 0.357 53.0 -9999.0 0.0 53.0 KIRREL -0.001 0.109 -9999.0 0.0 -0.454 32.0 32.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.008 0.116 -9999.0 0.0 -0.357 53.0 53.0 PLCG1 0.015 0.023 -9999.0 0.0 -0.452 1.0 1.0 ARRB2 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.022 0.12 -9999.0 0.0 -0.282 77.0 77.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.002 0.085 -9999.0 0.0 -0.265 52.0 52.0 FYN -0.023 0.09 0.208 23.0 -0.256 56.0 79.0 mol:Ca2+ 0.016 0.088 -9999.0 0.0 -0.278 39.0 39.0 mol:DAG 0.016 0.089 -9999.0 0.0 -0.279 39.0 39.0 NPHS2 0.012 0.035 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.016 0.089 -9999.0 0.0 -0.279 39.0 39.0 regulation of endocytosis 0.02 0.089 -9999.0 0.0 -0.24 56.0 56.0 Nephrin/NEPH1/podocin/Cholesterol 0.022 0.094 -9999.0 0.0 -0.269 52.0 52.0 establishment of cell polarity 0.007 0.116 -9999.0 0.0 -0.357 53.0 53.0 Nephrin/NEPH1/podocin/NCK1-2 0.048 0.1 -9999.0 0.0 -0.256 53.0 53.0 Nephrin/NEPH1/beta Arrestin2 0.021 0.091 -9999.0 0.0 -0.243 56.0 56.0 NPHS1 0.003 0.106 -9999.0 0.0 -0.467 27.0 27.0 Nephrin/NEPH1/podocin 0.022 0.094 -9999.0 0.0 -0.257 56.0 56.0 TJP1 0.024 0.02 -9999.0 0.0 -0.452 1.0 1.0 NCK1 0.025 0.027 -9999.0 0.0 -0.452 2.0 2.0 NCK2 0.026 0.019 -9999.0 0.0 -0.452 1.0 1.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.017 0.09 -9999.0 0.0 -0.281 39.0 39.0 CD2AP 0.005 0.098 -9999.0 0.0 -0.452 27.0 27.0 Nephrin/NEPH1/podocin/GRB2 0.035 0.1 -9999.0 0.0 -0.273 52.0 52.0 GRB2 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.039 0.103 0.22 22.0 -0.282 68.0 90.0 cytoskeleton organization -0.02 0.095 0.199 5.0 -0.315 50.0 55.0 Nephrin/NEPH1 0.011 0.084 -9999.0 0.0 -0.249 53.0 53.0 Nephrin/NEPH1/ZO-1 0.022 0.101 -9999.0 0.0 -0.289 53.0 53.0