Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.035 0.172 -9999.0 0.0 -0.539 54.0 54.0 IHH -0.012 0.136 -9999.0 0.0 -0.446 48.0 48.0 SHH Np/Cholesterol/GAS1 -0.022 0.115 0.186 4.0 -0.261 109.0 113.0 LRPAP1 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 dorsoventral neural tube patterning 0.022 0.114 0.259 109.0 -0.184 4.0 113.0 SMO/beta Arrestin2 -0.025 0.167 -9999.0 0.0 -0.433 65.0 65.0 SMO -0.039 0.167 -9999.0 0.0 -0.424 79.0 79.0 AKT1 -0.029 0.153 -9999.0 0.0 -0.452 46.0 46.0 ARRB2 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.024 0.064 -9999.0 0.0 -0.452 10.0 10.0 ADRBK1 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 heart looping -0.037 0.165 -9999.0 0.0 -0.418 79.0 79.0 STIL -0.025 0.13 0.181 28.0 -0.294 94.0 122.0 DHH N/PTCH2 0.006 0.113 -9999.0 0.0 -0.352 53.0 53.0 DHH N/PTCH1 -0.016 0.139 -9999.0 0.0 -0.299 106.0 106.0 PIK3CA 0.025 0.027 -9999.0 0.0 -0.452 2.0 2.0 DHH 0.001 0.106 -9999.0 0.0 -0.452 31.0 31.0 PTHLH -0.062 0.25 -9999.0 0.0 -0.647 80.0 80.0 determination of left/right symmetry -0.037 0.165 -9999.0 0.0 -0.418 79.0 79.0 PIK3R1 0.024 0.028 -9999.0 0.0 -0.452 2.0 2.0 skeletal system development -0.061 0.247 -9999.0 0.0 -0.64 80.0 80.0 IHH N/Hhip -0.026 0.158 -9999.0 0.0 -0.378 95.0 95.0 DHH N/Hhip -0.016 0.144 -9999.0 0.0 -0.357 88.0 88.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.037 0.165 -9999.0 0.0 -0.418 79.0 79.0 pancreas development -0.024 0.151 -9999.0 0.0 -0.452 67.0 67.0 HHAT 0.02 0.051 -9999.0 0.0 -0.452 7.0 7.0 PI3K 0.035 0.031 -9999.0 0.0 -0.327 4.0 4.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.028 0.169 -9999.0 0.0 -0.452 82.0 82.0 somite specification -0.037 0.165 -9999.0 0.0 -0.418 79.0 79.0 SHH Np/Cholesterol/PTCH1 -0.024 0.131 -9999.0 0.0 -0.304 95.0 95.0 SHH Np/Cholesterol/PTCH2 -0.003 0.085 -9999.0 0.0 -0.263 56.0 56.0 SHH Np/Cholesterol/Megalin 0.008 0.067 0.185 1.0 -0.254 35.0 36.0 SHH -0.008 0.077 0.233 1.0 -0.326 33.0 34.0 catabolic process -0.02 0.128 -9999.0 0.0 -0.329 82.0 82.0 SMO/Vitamin D3 -0.033 0.157 -9999.0 0.0 -0.383 83.0 83.0 SHH Np/Cholesterol/Hhip -0.018 0.111 0.186 2.0 -0.277 88.0 90.0 LRP2 0.012 0.032 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.037 0.152 -9999.0 0.0 -0.382 79.0 79.0 SHH Np/Cholesterol/BOC 0.007 0.076 0.186 2.0 -0.264 41.0 43.0 SHH Np/Cholesterol/CDO 0.005 0.071 -9999.0 0.0 -0.263 38.0 38.0 mesenchymal cell differentiation 0.018 0.11 0.276 88.0 -0.184 2.0 90.0 mol:Vitamin D3 -0.017 0.139 0.199 31.0 -0.306 94.0 125.0 IHH N/PTCH2 -0.003 0.123 -9999.0 0.0 -0.342 64.0 64.0 CDON 0.022 0.048 -9999.0 0.0 -0.452 6.0 6.0 IHH N/PTCH1 -0.01 0.133 -9999.0 0.0 -0.33 83.0 83.0 Megalin/LRPAP1 0.038 0.022 -9999.0 0.0 -0.33 1.0 1.0 PTCH2 0.006 0.099 -9999.0 0.0 -0.452 27.0 27.0 SHH Np/Cholesterol -0.002 0.061 -9999.0 0.0 -0.247 35.0 35.0 PTCH1 -0.02 0.128 -9999.0 0.0 -0.33 82.0 82.0 HHIP -0.024 0.151 -9999.0 0.0 -0.452 67.0 67.0