Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.033 -9999.0 0.0 -0.235 10.0 10.0 epithelial cell differentiation 0.053 0.024 -9999.0 0.0 -0.237 3.0 3.0 CYFIP2 0.018 0.061 -9999.0 0.0 -0.452 10.0 10.0 ENAH -0.024 0.05 0.267 2.0 -0.392 4.0 6.0 EGFR 0.021 0.039 -9999.0 0.0 -0.452 4.0 4.0 EPHA2 0.024 0.028 -9999.0 0.0 -0.452 2.0 2.0 MYO6 -0.015 0.021 0.173 3.0 -0.23 3.0 6.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.045 0.05 -9999.0 0.0 -0.298 12.0 12.0 AQP5 -0.009 0.096 -9999.0 0.0 -0.453 26.0 26.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.014 0.025 0.172 5.0 -0.228 4.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.029 0.06 0.18 5.0 -0.235 42.0 47.0 EGF -0.033 0.176 -9999.0 0.0 -0.452 89.0 89.0 NCKAP1 0.025 0.027 -9999.0 0.0 -0.452 2.0 2.0 AQP3 0.005 0.056 -9999.0 0.0 -0.443 8.0 8.0 cortical microtubule organization 0.053 0.024 -9999.0 0.0 -0.237 3.0 3.0 GO:0000145 -0.014 0.023 0.159 5.0 -0.218 4.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.058 0.026 -9999.0 0.0 -0.239 3.0 3.0 MLLT4 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 ARF6/GDP -0.025 0.029 -9999.0 0.0 -0.277 6.0 6.0 ARF6 0.024 0.02 -9999.0 0.0 -0.452 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.058 0.038 -9999.0 0.0 -0.311 4.0 4.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.02 0.167 1.0 -0.232 1.0 2.0 PVRL2 0.026 0.02 -9999.0 0.0 -0.452 1.0 1.0 ZYX -0.015 0.02 0.173 1.0 -0.231 4.0 5.0 ARF6/GTP 0.061 0.044 -9999.0 0.0 -0.341 4.0 4.0 CDH1 0.026 0.02 -9999.0 0.0 -0.452 1.0 1.0 EGFR/EGFR/EGF/EGF 0.009 0.099 -9999.0 0.0 -0.228 85.0 85.0 RhoA/GDP 0.053 0.027 -9999.0 0.0 -0.229 4.0 4.0 actin cytoskeleton organization -0.016 0.022 0.16 2.0 -0.222 5.0 7.0 IGF-1R heterotetramer 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 GIT1 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 IGF1R 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 IGF1 -0.009 0.136 -9999.0 0.0 -0.452 52.0 52.0 DIAPH1 0.027 0.133 -9999.0 0.0 -0.581 23.0 23.0 Wnt receptor signaling pathway -0.053 0.024 0.237 3.0 -9999.0 0.0 3.0 RHOA 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 RhoA/GTP -0.026 0.029 -9999.0 0.0 -0.268 7.0 7.0 CTNNA1 0.024 0.028 -9999.0 0.0 -0.452 2.0 2.0 VCL -0.016 0.022 0.162 2.0 -0.226 5.0 7.0 EFNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.016 0.025 0.164 5.0 -0.225 4.0 9.0 Ephrin A1/EPHA2 0.043 0.031 -9999.0 0.0 -0.227 5.0 5.0 SEC6/SEC8 -0.023 0.02 -9999.0 0.0 -0.221 5.0 5.0 MGAT3 -0.029 0.061 0.182 5.0 -0.238 42.0 47.0 HGF/MET 0.031 0.069 -9999.0 0.0 -0.227 39.0 39.0 HGF 0.001 0.111 -9999.0 0.0 -0.452 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.034 -9999.0 0.0 -0.236 10.0 10.0 actin cable formation -0.008 0.072 0.234 17.0 -0.306 9.0 26.0 KIAA1543 -0.014 0.024 0.16 5.0 -0.221 4.0 9.0 KIFC3 -0.019 0.031 0.173 1.0 -0.232 11.0 12.0 NCK1 0.025 0.027 -9999.0 0.0 -0.452 2.0 2.0 EXOC3 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.014 0.024 0.173 5.0 -0.23 3.0 8.0 NCK1/GIT1 0.036 0.027 -9999.0 0.0 -0.326 3.0 3.0 mol:GDP 0.053 0.024 -9999.0 0.0 -0.237 3.0 3.0 EXOC4 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.015 0.02 0.173 2.0 -0.23 3.0 5.0 PIP5K1C -0.015 0.025 0.173 5.0 -0.231 4.0 9.0 LIMA1 0.021 0.051 -9999.0 0.0 -0.452 7.0 7.0 ABI1 0.026 0.019 -9999.0 0.0 -0.452 1.0 1.0 ROCK1 -0.018 0.051 0.287 4.0 -0.368 3.0 7.0 adherens junction assembly -0.006 0.06 0.268 4.0 -0.377 8.0 12.0 IGF-1R heterotetramer/IGF1 0.025 0.081 -9999.0 0.0 -0.23 53.0 53.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.022 -9999.0 0.0 -0.326 2.0 2.0 MET 0.024 0.028 -9999.0 0.0 -0.452 2.0 2.0 PLEKHA7 -0.015 0.025 0.173 5.0 -0.231 4.0 9.0 mol:GTP 0.056 0.038 -9999.0 0.0 -0.309 4.0 4.0 establishment of epithelial cell apical/basal polarity -0.014 0.05 0.313 3.0 -9999.0 0.0 3.0 cortical actin cytoskeleton stabilization 0.018 0.033 -9999.0 0.0 -0.235 10.0 10.0 regulation of cell-cell adhesion -0.016 0.022 0.16 2.0 -0.222 5.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.034 -9999.0 0.0 -0.236 10.0 10.0