Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling mediated by p38-alpha and p38-beta	90.0	3972.0	44.0	-0.128	0.026	1000.0	-1000.0	-0.024	-1000.0
IL23-mediated signaling events	89.0	5347.0	60.0	-0.408	0.026	1000.0	-1000.0	-0.089	-1000.0
IL4-mediated signaling events	83.0	7615.0	91.0	-0.584	0.493	1000.0	-1000.0	-0.127	-1000.0
Endothelins	61.0	5922.0	96.0	-0.125	0.028	1000.0	-1000.0	-0.043	-1000.0
FOXA2 and FOXA3 transcription factor networks	56.0	2588.0	46.0	-0.265	0.027	1000.0	-1000.0	-0.089	-1000.0
TCR signaling in naïve CD8+ T cells	56.0	5262.0	93.0	-0.094	0.038	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by the Hedgehog family	55.0	2881.0	52.0	-0.062	0.038	1000.0	-1000.0	-0.025	-1000.0
Fc-epsilon receptor I signaling in mast cells	52.0	5068.0	97.0	-0.139	0.048	1000.0	-1000.0	-0.054	-1000.0
Ephrin B reverse signaling	52.0	2507.0	48.0	-0.106	0.036	1000.0	-1000.0	-0.023	-1000.0
Osteopontin-mediated events	51.0	1944.0	38.0	-0.085	0.03	1000.0	-1000.0	-0.041	-1000.0
Noncanonical Wnt signaling pathway	51.0	1345.0	26.0	-0.073	0.025	1000.0	-1000.0	-0.035	-1000.0
Wnt signaling	51.0	361.0	7.0	-0.072	0.019	1000.0	-1000.0	-0.011	-1000.0
BCR signaling pathway	49.0	4858.0	99.0	-0.138	0.029	1000.0	-1000.0	-0.055	-1000.0
IL12-mediated signaling events	48.0	4194.0	87.0	-0.208	0.038	1000.0	-1000.0	-0.068	-1000.0
Reelin signaling pathway	45.0	2575.0	56.0	-0.064	0.066	1000.0	-1000.0	-0.037	-1000.0
Syndecan-1-mediated signaling events	44.0	1500.0	34.0	-0.051	0.026	1000.0	-1000.0	-0.029	-1000.0
TCGA08_p53	44.0	308.0	7.0	-0.031	0.025	1000.0	-1000.0	-0.005	-1000.0
HIF-1-alpha transcription factor network	43.0	3314.0	76.0	-0.156	0.029	1000.0	-1000.0	-0.095	-1000.0
Glypican 1 network	43.0	2106.0	48.0	-0.073	0.045	1000.0	-1000.0	-0.026	-1000.0
amb2 Integrin signaling	41.0	3410.0	82.0	-0.079	0.034	1000.0	-1000.0	-0.036	-1000.0
Syndecan-4-mediated signaling events	41.0	2796.0	67.0	-0.069	0.037	1000.0	-1000.0	-0.033	-1000.0
TCGA08_retinoblastoma	40.0	322.0	8.0	-0.006	0.029	1000.0	-1000.0	-0.002	-1000.0
EGFR-dependent Endothelin signaling events	40.0	842.0	21.0	-0.049	0.038	1000.0	-1000.0	-0.037	-1000.0
Thromboxane A2 receptor signaling	39.0	4113.0	105.0	-0.085	0.037	1000.0	-1000.0	-0.04	-1000.0
LPA receptor mediated events	38.0	3977.0	102.0	-0.073	0.031	1000.0	-1000.0	-0.056	-1000.0
Ephrin A  reverse signaling	37.0	263.0	7.0	-0.029	0.009	1000.0	-1000.0	-0.006	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	35.0	1190.0	34.0	-0.039	0.048	1000.0	-1000.0	-0.025	-1000.0
EPHB forward signaling	35.0	3024.0	85.0	-0.048	0.077	1000.0	-1000.0	-0.055	-1000.0
p75(NTR)-mediated signaling	34.0	4326.0	125.0	-0.062	0.065	1000.0	-1000.0	-0.063	-1000.0
Glucocorticoid receptor regulatory network	34.0	3933.0	114.0	-0.226	0.124	1000.0	-1000.0	-0.049	-1000.0
Signaling events regulated by Ret tyrosine kinase	34.0	2801.0	82.0	-0.049	0.034	1000.0	-1000.0	-0.043	-1000.0
PDGFR-beta signaling pathway	34.0	3343.0	97.0	-0.088	0.073	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	34.0	2710.0	78.0	-0.135	0.035	1000.0	-1000.0	-0.04	-1000.0
JNK signaling in the CD4+ TCR pathway	33.0	577.0	17.0	-0.047	0.026	1000.0	-1000.0	-0.03	-1000.0
Calcium signaling in the CD4+ TCR pathway	33.0	1050.0	31.0	-0.078	0.026	1000.0	-1000.0	-0.034	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	33.0	2246.0	68.0	-0.169	0.065	1000.0	-1000.0	-0.081	-1000.0
BMP receptor signaling	30.0	2508.0	81.0	-0.054	0.042	1000.0	-1000.0	-0.036	-1000.0
Effects of Botulinum toxin	29.0	776.0	26.0	-0.069	0.036	1000.0	-1000.0	-0.006	-1000.0
Caspase cascade in apoptosis	28.0	2131.0	74.0	-0.059	0.052	1000.0	-1000.0	-0.037	-1000.0
FAS signaling pathway (CD95)	28.0	1341.0	47.0	-0.127	0.04	1000.0	-1000.0	-0.03	-1000.0
Angiopoietin receptor Tie2-mediated signaling	28.0	2549.0	88.0	-0.054	0.037	1000.0	-1000.0	-0.058	-1000.0
Syndecan-2-mediated signaling events	27.0	1870.0	69.0	-0.023	0.037	1000.0	-1000.0	-0.039	-1000.0
Nongenotropic Androgen signaling	27.0	1441.0	52.0	-0.029	0.047	1000.0	-1000.0	-0.027	-1000.0
Visual signal transduction: Rods	27.0	1417.0	52.0	-0.049	0.041	1000.0	-1000.0	-0.034	-1000.0
IGF1 pathway	26.0	1508.0	57.0	-0.037	0.051	1000.0	-1000.0	-0.038	-1000.0
Plasma membrane estrogen receptor signaling	26.0	2286.0	86.0	-0.032	0.07	1000.0	-1000.0	-0.043	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	26.0	3177.0	120.0	-0.075	0.071	1000.0	-1000.0	-0.037	-1000.0
Cellular roles of Anthrax toxin	25.0	976.0	39.0	-0.028	0.025	1000.0	-1000.0	-0.022	-1000.0
Retinoic acid receptors-mediated signaling	25.0	1463.0	58.0	-0.042	0.047	1000.0	-1000.0	-0.039	-1000.0
Integrins in angiogenesis	25.0	2128.0	84.0	-0.082	0.057	1000.0	-1000.0	-0.032	-1000.0
a4b1 and a4b7 Integrin signaling	24.0	120.0	5.0	0.004	0.022	1000.0	-1000.0	0.007	-1000.0
IL1-mediated signaling events	24.0	1531.0	62.0	-0.028	0.058	1000.0	-1000.0	-0.034	-1000.0
Canonical Wnt signaling pathway	24.0	1259.0	51.0	-0.104	0.079	1000.0	-1000.0	-0.041	-1000.0
Class I PI3K signaling events	24.0	1774.0	73.0	-0.063	0.032	1000.0	-1000.0	-0.033	-1000.0
ErbB2/ErbB3 signaling events	23.0	1520.0	65.0	-0.049	0.038	1000.0	-1000.0	-0.044	-1000.0
Arf6 signaling events	23.0	1458.0	62.0	-0.048	0.058	1000.0	-1000.0	-0.028	-1000.0
Presenilin action in Notch and Wnt signaling	23.0	1411.0	61.0	-0.039	0.065	1000.0	-1000.0	-0.03	-1000.0
Ceramide signaling pathway	23.0	1802.0	76.0	-0.037	0.066	1000.0	-1000.0	-0.03	-1000.0
IL6-mediated signaling events	23.0	1757.0	75.0	-0.036	0.047	1000.0	-1000.0	-0.05	-1000.0
Ras signaling in the CD4+ TCR pathway	23.0	398.0	17.0	-0.016	0.039	1000.0	-1000.0	-0.022	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	22.0	1220.0	54.0	-0.047	0.035	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by PTP1B	22.0	1688.0	76.0	-0.05	0.042	1000.0	-1000.0	-0.029	-1000.0
IFN-gamma pathway	22.0	1522.0	68.0	-0.048	0.037	1000.0	-1000.0	-0.051	-1000.0
S1P1 pathway	21.0	759.0	36.0	-0.06	0.033	1000.0	-1000.0	-0.037	-1000.0
IL27-mediated signaling events	21.0	1081.0	51.0	-0.114	0.027	1000.0	-1000.0	-0.054	-1000.0
VEGFR1 specific signals	21.0	1222.0	56.0	-0.004	0.078	1000.0	-1000.0	-0.044	-1000.0
Glypican 2 network	19.0	78.0	4.0	0.014	0.023	1000.0	-1000.0	0.008	-1000.0
FOXM1 transcription factor network	19.0	1010.0	51.0	-0.107	0.045	1000.0	-1000.0	-0.105	-1000.0
Visual signal transduction: Cones	18.0	719.0	38.0	-0.019	0.039	1000.0	-1000.0	-0.011	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	18.0	685.0	37.0	-0.024	0.051	1000.0	-1000.0	-0.031	-1000.0
Regulation of p38-alpha and p38-beta	18.0	997.0	54.0	-0.064	0.051	1000.0	-1000.0	-0.041	-1000.0
EPO signaling pathway	17.0	985.0	55.0	-0.01	0.06	1000.0	-1000.0	-0.033	-1000.0
PDGFR-alpha signaling pathway	17.0	755.0	44.0	-0.032	0.057	1000.0	-1000.0	-0.032	-1000.0
S1P4 pathway	17.0	441.0	25.0	-0.016	0.036	1000.0	-1000.0	-0.026	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	16.0	1416.0	85.0	-0.06	0.046	1000.0	-1000.0	-0.044	-1000.0
Syndecan-3-mediated signaling events	16.0	572.0	35.0	-0.016	0.065	1000.0	-1000.0	-0.024	-1000.0
LPA4-mediated signaling events	15.0	181.0	12.0	-0.043	0.006	1000.0	-1000.0	-0.021	-1000.0
Class I PI3K signaling events mediated by Akt	15.0	1057.0	68.0	-0.044	0.051	1000.0	-1000.0	-0.027	-1000.0
Nectin adhesion pathway	15.0	974.0	63.0	-0.012	0.069	1000.0	-1000.0	-0.042	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	15.0	801.0	52.0	-0.03	0.075	1000.0	-1000.0	-0.045	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	15.0	678.0	45.0	-0.033	0.066	1000.0	-1000.0	-0.043	-1000.0
Aurora B signaling	15.0	1013.0	67.0	-0.156	0.062	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by PI3K	14.0	847.0	58.0	-0.017	0.043	1000.0	-1000.0	-0.033	-1000.0
IL2 signaling events mediated by STAT5	14.0	328.0	22.0	-0.032	0.027	1000.0	-1000.0	-0.043	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	14.0	475.0	33.0	-0.007	0.063	1000.0	-1000.0	-0.028	-1000.0
Coregulation of Androgen receptor activity	13.0	1046.0	76.0	-0.112	0.053	1000.0	-1000.0	-0.024	-1000.0
Arf6 downstream pathway	13.0	571.0	43.0	-0.029	0.039	1000.0	-1000.0	-0.02	-1000.0
mTOR signaling pathway	13.0	739.0	53.0	-0.072	0.029	1000.0	-1000.0	-0.035	-1000.0
Paxillin-dependent events mediated by a4b1	13.0	483.0	36.0	-0.041	0.042	1000.0	-1000.0	-0.034	-1000.0
S1P3 pathway	13.0	548.0	42.0	-0.021	0.041	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by PRL	13.0	453.0	34.0	-0.02	0.076	1000.0	-1000.0	-0.033	-1000.0
Regulation of Androgen receptor activity	13.0	931.0	70.0	-0.14	0.06	1000.0	-1000.0	-0.036	-1000.0
PLK1 signaling events	12.0	1036.0	85.0	-0.007	0.056	1000.0	-1000.0	-0.022	-1000.0
S1P5 pathway	12.0	213.0	17.0	-0.009	0.029	1000.0	-1000.0	-0.013	-1000.0
Regulation of Telomerase	12.0	1250.0	102.0	-0.06	0.051	1000.0	-1000.0	-0.044	-1000.0
Insulin Pathway	12.0	939.0	74.0	-0.046	0.079	1000.0	-1000.0	-0.048	-1000.0
Class IB PI3K non-lipid kinase events	12.0	36.0	3.0	-0.017	0.017	1000.0	-1000.0	-0.009	-1000.0
ErbB4 signaling events	11.0	824.0	69.0	-0.077	0.051	1000.0	-1000.0	-0.035	-1000.0
Sphingosine 1-phosphate (S1P) pathway	11.0	313.0	28.0	-0.011	0.041	1000.0	-1000.0	-0.023	-1000.0
Hedgehog signaling events mediated by Gli proteins	11.0	770.0	65.0	-0.02	0.047	1000.0	-1000.0	-0.032	-1000.0
Insulin-mediated glucose transport	11.0	372.0	32.0	-0.127	0.041	1000.0	-1000.0	-0.025	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	11.0	970.0	83.0	-0.052	0.055	1000.0	-1000.0	-0.023	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	821.0	74.0	-0.053	0.061	1000.0	-1000.0	-0.053	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	11.0	301.0	27.0	-0.024	0.041	1000.0	-1000.0	-0.035	-1000.0
Arf6 trafficking events	11.0	792.0	71.0	-0.041	0.045	1000.0	-1000.0	-0.029	-1000.0
Signaling mediated by p38-gamma and p38-delta	10.0	155.0	15.0	-0.02	0.024	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling in the nascent adherens junction	10.0	764.0	76.0	-0.014	0.079	1000.0	-1000.0	-0.055	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1323.0	136.0	-0.054	0.049	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by HDAC Class III	9.0	390.0	40.0	-0.045	0.048	1000.0	-1000.0	-0.03	-1000.0
ceramide signaling pathway	9.0	444.0	49.0	-0.0	0.036	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	9.0	1246.0	125.0	-0.021	0.093	1000.0	-1000.0	-0.044	-1000.0
TCGA08_rtk_signaling	9.0	254.0	26.0	-0.025	0.058	1000.0	-1000.0	-0.009	-1000.0
BARD1 signaling events	8.0	458.0	57.0	-0.028	0.066	1000.0	-1000.0	-0.031	-1000.0
HIF-2-alpha transcription factor network	8.0	383.0	43.0	-0.083	0.085	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by HDAC Class I	8.0	849.0	104.0	-0.051	0.061	1000.0	-1000.0	-0.029	-1000.0
FoxO family signaling	8.0	520.0	64.0	-0.063	0.063	1000.0	-1000.0	-0.061	-1000.0
Signaling events mediated by HDAC Class II	6.0	509.0	75.0	-0.021	0.069	1000.0	-1000.0	-0.029	-1000.0
Arf1 pathway	6.0	370.0	54.0	-0.001	0.04	1000.0	-1000.0	-0.014	-1000.0
Canonical NF-kappaB pathway	5.0	213.0	39.0	-0.007	0.055	1000.0	-1000.0	-0.033	-1000.0
Aurora C signaling	5.0	35.0	7.0	0.0	0.034	1000.0	-1000.0	-0.017	-1000.0
p38 MAPK signaling pathway	5.0	235.0	44.0	-0.005	0.058	1000.0	-1000.0	-0.021	-1000.0
PLK2 and PLK4 events	3.0	9.0	3.0	0.006	-1000.0	1000.0	-1000.0	-0.005	-1000.0
Aurora A signaling	3.0	204.0	60.0	-0.014	0.07	1000.0	-1000.0	-0.019	-1000.0
Atypical NF-kappaB pathway	3.0	95.0	31.0	-0.0	0.047	1000.0	-1000.0	-0.015	-1000.0
Rapid glucocorticoid signaling	3.0	62.0	20.0	-0.014	0.029	1000.0	-1000.0	-0.006	-1000.0
E-cadherin signaling in keratinocytes	3.0	171.0	43.0	-0.039	0.079	1000.0	-1000.0	-0.028	-1000.0
TRAIL signaling pathway	2.0	136.0	48.0	-0.0	0.055	1000.0	-1000.0	-0.035	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	29.0	23.0	0.012	0.036	1000.0	-1000.0	-0.029	-1000.0
Circadian rhythm pathway	1.0	26.0	22.0	-0.007	0.059	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling events	1.0	5.0	5.0	0.025	0.051	1000.0	-1000.0	0.011	-1000.0
Alternative NF-kappaB pathway	1.0	19.0	13.0	-0.0	0.07	1000.0	-1000.0	-0.0	-1000.0
Total	3109	187007	7203	-7.84965006297	-993.402780331	131000	-131000	-4.57975662504	-131000