Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.009 0.221 -9999.0 0.0 -0.773 13.0 13.0 IHH 0.002 0.122 -9999.0 0.0 -0.626 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.143 0.2 -9999.0 0.0 -0.416 55.0 55.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.142 0.198 0.413 55.0 -9999.0 0.0 55.0 SMO/beta Arrestin2 -0.014 0.197 -9999.0 0.0 -0.669 12.0 12.0 SMO -0.023 0.205 -9999.0 0.0 -0.67 13.0 13.0 AKT1 0.011 0.128 -9999.0 0.0 -0.656 4.0 4.0 ARRB2 0.015 0.042 -9999.0 0.0 -0.609 1.0 1.0 BOC -0.001 0.094 -9999.0 0.0 -0.484 8.0 8.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.022 0.201 -9999.0 0.0 -0.654 13.0 13.0 STIL -0.012 0.183 -9999.0 0.0 -0.558 13.0 13.0 DHH N/PTCH2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.019 0.159 -9999.0 0.0 -0.627 9.0 9.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.001 0.266 -9999.0 0.0 -0.971 13.0 13.0 determination of left/right symmetry -0.022 0.201 -9999.0 0.0 -0.654 13.0 13.0 PIK3R1 0.009 0.072 -9999.0 0.0 -0.609 3.0 3.0 skeletal system development -0.0 0.261 -9999.0 0.0 -0.954 13.0 13.0 IHH N/Hhip -0.068 0.207 -9999.0 0.0 -0.474 43.0 43.0 DHH N/Hhip -0.052 0.168 -9999.0 0.0 -0.408 40.0 40.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.022 0.201 -9999.0 0.0 -0.654 13.0 13.0 pancreas development -0.088 0.227 -9999.0 0.0 -0.568 40.0 40.0 HHAT -0.038 0.172 -9999.0 0.0 -0.568 21.0 21.0 PI3K 0.02 0.054 -9999.0 0.0 -0.441 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.222 0.276 -9999.0 0.0 -0.531 97.0 97.0 somite specification -0.022 0.201 -9999.0 0.0 -0.654 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.01 0.178 -9999.0 0.0 -0.545 13.0 13.0 SHH Np/Cholesterol/PTCH2 -0.009 0.112 -9999.0 0.0 -0.349 17.0 17.0 SHH Np/Cholesterol/Megalin -0.011 0.114 -9999.0 0.0 -0.349 17.0 17.0 SHH -0.023 0.144 -9999.0 0.0 -0.41 26.0 26.0 catabolic process 0.012 0.175 -9999.0 0.0 -0.565 14.0 14.0 SMO/Vitamin D3 -0.026 0.199 -9999.0 0.0 -0.61 14.0 14.0 SHH Np/Cholesterol/Hhip -0.069 0.18 -9999.0 0.0 -0.394 41.0 41.0 LRP2 0.013 0.046 -9999.0 0.0 -0.466 2.0 2.0 receptor-mediated endocytosis -0.014 0.193 -9999.0 0.0 -0.559 16.0 16.0 SHH Np/Cholesterol/BOC -0.019 0.12 -9999.0 0.0 -0.348 18.0 18.0 SHH Np/Cholesterol/CDO -0.011 0.114 -9999.0 0.0 -0.349 17.0 17.0 mesenchymal cell differentiation 0.069 0.178 0.391 41.0 -9999.0 0.0 41.0 mol:Vitamin D3 -0.007 0.181 -9999.0 0.0 -0.547 13.0 13.0 IHH N/PTCH2 0.017 0.077 -9999.0 0.0 -0.441 5.0 5.0 CDON 0.013 0.046 -9999.0 0.0 -0.466 2.0 2.0 IHH N/PTCH1 0.013 0.177 -9999.0 0.0 -0.571 14.0 14.0 Megalin/LRPAP1 0.023 0.033 -9999.0 0.0 -0.321 2.0 2.0 PTCH2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.02 0.112 -9999.0 0.0 -0.319 26.0 26.0 PTCH1 0.012 0.176 -9999.0 0.0 -0.568 14.0 14.0 HHIP -0.088 0.227 -9999.0 0.0 -0.569 40.0 40.0