Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.008 0.157 -9999.0 0.0 -0.662 9.0 9.0 IHH 0.023 0.102 -9999.0 0.0 -0.559 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.073 0.137 -9999.0 0.0 -0.298 48.0 48.0 LRPAP1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.072 0.136 0.296 48.0 -9999.0 0.0 48.0 SMO/beta Arrestin2 0.001 0.157 -9999.0 0.0 -0.598 8.0 8.0 SMO -0.013 0.156 -9999.0 0.0 -0.601 9.0 9.0 AKT1 -0.014 0.16 -9999.0 0.0 -0.549 10.0 10.0 ARRB2 0.027 0.037 -9999.0 0.0 -0.469 1.0 1.0 BOC 0.028 0.051 -9999.0 0.0 -0.231 7.0 7.0 ADRBK1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.012 0.153 -9999.0 0.0 -0.589 9.0 9.0 STIL -0.009 0.127 0.365 1.0 -0.396 10.0 11.0 DHH N/PTCH2 0.053 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.032 0.12 -9999.0 0.0 -0.451 9.0 9.0 PIK3CA 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.005 0.206 -9999.0 0.0 -0.915 9.0 9.0 determination of left/right symmetry -0.012 0.153 -9999.0 0.0 -0.589 9.0 9.0 PIK3R1 0.029 0.06 -9999.0 0.0 -0.469 3.0 3.0 skeletal system development -0.005 0.203 -9999.0 0.0 -0.902 9.0 9.0 IHH N/Hhip -0.015 0.161 -9999.0 0.0 -0.397 29.0 29.0 DHH N/Hhip -0.004 0.13 -9999.0 0.0 -0.338 26.0 26.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.012 0.153 -9999.0 0.0 -0.589 9.0 9.0 pancreas development -0.036 0.168 -9999.0 0.0 -0.386 37.0 37.0 HHAT -0.001 0.125 -9999.0 0.0 -0.381 19.0 19.0 PI3K 0.047 0.047 -9999.0 0.0 -0.338 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.116 0.197 -9999.0 0.0 -0.318 92.0 92.0 somite specification -0.012 0.153 -9999.0 0.0 -0.589 9.0 9.0 SHH Np/Cholesterol/PTCH1 -0.002 0.123 -9999.0 0.0 -0.42 9.0 9.0 SHH Np/Cholesterol/PTCH2 0.01 0.078 -9999.0 0.0 -0.264 14.0 14.0 SHH Np/Cholesterol/Megalin 0.009 0.079 -9999.0 0.0 -0.265 14.0 14.0 SHH -0.011 0.093 -9999.0 0.0 -0.345 14.0 14.0 catabolic process 0.014 0.126 -9999.0 0.0 -0.441 12.0 12.0 SMO/Vitamin D3 -0.013 0.144 -9999.0 0.0 -0.523 9.0 9.0 SHH Np/Cholesterol/Hhip -0.03 0.127 -9999.0 0.0 -0.295 35.0 35.0 LRP2 0.035 0.022 -9999.0 0.0 -0.191 2.0 2.0 receptor-mediated endocytosis -0.017 0.143 -9999.0 0.0 -0.519 9.0 9.0 SHH Np/Cholesterol/BOC 0.006 0.08 -9999.0 0.0 -0.266 14.0 14.0 SHH Np/Cholesterol/CDO 0.009 0.079 -9999.0 0.0 -0.265 14.0 14.0 mesenchymal cell differentiation 0.03 0.126 0.294 35.0 -9999.0 0.0 35.0 mol:Vitamin D3 0.004 0.131 0.387 1.0 -0.422 9.0 10.0 IHH N/PTCH2 0.043 0.068 -9999.0 0.0 -0.343 5.0 5.0 CDON 0.034 0.023 -9999.0 0.0 -0.191 2.0 2.0 IHH N/PTCH1 0.026 0.13 -9999.0 0.0 -0.445 12.0 12.0 Megalin/LRPAP1 0.051 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.003 0.073 -9999.0 0.0 -0.264 14.0 14.0 PTCH1 0.014 0.126 -9999.0 0.0 -0.443 12.0 12.0 HHIP -0.037 0.168 -9999.0 0.0 -0.387 37.0 37.0