Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.092 0.173 0.413 40.0 -9999.0 0.0 40.0 KIRREL -0.017 0.108 -9999.0 0.0 -0.656 5.0 5.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.092 0.173 -9999.0 0.0 -0.414 40.0 40.0 PLCG1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.077 0.132 -9999.0 0.0 -0.363 21.0 21.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.031 0.109 -9999.0 0.0 -0.303 15.0 15.0 FYN -0.056 0.13 -9999.0 0.0 -0.343 21.0 21.0 mol:Ca2+ -0.077 0.131 -9999.0 0.0 -0.36 21.0 21.0 mol:DAG -0.077 0.131 -9999.0 0.0 -0.361 21.0 21.0 NPHS2 -0.031 0.117 -9999.0 0.0 -0.487 11.0 11.0 mol:IP3 -0.077 0.131 -9999.0 0.0 -0.361 21.0 21.0 regulation of endocytosis -0.065 0.112 -9999.0 0.0 -0.317 21.0 21.0 Nephrin/NEPH1/podocin/Cholesterol -0.079 0.135 -9999.0 0.0 -0.37 21.0 21.0 establishment of cell polarity -0.092 0.173 -9999.0 0.0 -0.413 40.0 40.0 Nephrin/NEPH1/podocin/NCK1-2 -0.069 0.117 -9999.0 0.0 -0.428 1.0 1.0 Nephrin/NEPH1/beta Arrestin2 -0.061 0.116 -9999.0 0.0 -0.321 21.0 21.0 NPHS1 -0.102 0.225 -9999.0 0.0 -0.558 35.0 35.0 Nephrin/NEPH1/podocin -0.071 0.122 -9999.0 0.0 -0.344 21.0 21.0 TJP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.077 0.132 -9999.0 0.0 -0.363 21.0 21.0 CD2AP 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.077 0.132 -9999.0 0.0 -0.363 21.0 21.0 GRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.056 0.132 -9999.0 0.0 -0.333 22.0 22.0 cytoskeleton organization -0.039 0.135 -9999.0 0.0 -0.38 15.0 15.0 Nephrin/NEPH1 -0.065 0.124 -9999.0 0.0 -0.349 21.0 21.0 Nephrin/NEPH1/ZO-1 -0.071 0.137 -9999.0 0.0 -0.385 21.0 21.0