Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.364 0.32 -9999.0 0.0 -0.721 72.0 72.0 IHH -0.385 0.287 -9999.0 0.0 -0.593 116.0 116.0 SHH Np/Cholesterol/GAS1 -0.21 0.21 -9999.0 0.0 -0.38 102.0 102.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.209 0.208 0.377 102.0 -9999.0 0.0 102.0 SMO/beta Arrestin2 -0.328 0.308 -9999.0 0.0 -0.637 75.0 75.0 SMO -0.353 0.329 -9999.0 0.0 -0.638 88.0 88.0 AKT1 -0.131 0.115 -9999.0 0.0 -0.334 11.0 11.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.02 0.13 -9999.0 0.0 -0.556 10.0 10.0 ADRBK1 0.008 0.037 -9999.0 0.0 -0.49 1.0 1.0 heart looping -0.346 0.318 -9999.0 0.0 -0.624 88.0 88.0 STIL -0.345 0.264 -9999.0 0.0 -0.552 91.0 91.0 DHH N/PTCH2 -0.028 0.115 -9999.0 0.0 -0.471 11.0 11.0 DHH N/PTCH1 -0.276 0.244 -9999.0 0.0 -0.539 70.0 70.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.021 0.14 -9999.0 0.0 -0.636 9.0 9.0 PTHLH -0.512 0.488 -9999.0 0.0 -1.068 72.0 72.0 determination of left/right symmetry -0.346 0.318 -9999.0 0.0 -0.624 88.0 88.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.503 0.477 -9999.0 0.0 -1.048 72.0 72.0 IHH N/Hhip -0.315 0.258 -9999.0 0.0 -0.511 99.0 99.0 DHH N/Hhip -0.112 0.203 -9999.0 0.0 -0.45 46.0 46.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.346 0.318 -9999.0 0.0 -0.624 88.0 88.0 pancreas development -0.116 0.246 -9999.0 0.0 -0.586 39.0 39.0 HHAT -0.022 0.143 -9999.0 0.0 -0.654 9.0 9.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.1 0.23 -9999.0 0.0 -0.57 35.0 35.0 somite specification -0.346 0.318 -9999.0 0.0 -0.624 88.0 88.0 SHH Np/Cholesterol/PTCH1 -0.366 0.273 -9999.0 0.0 -0.561 99.0 99.0 SHH Np/Cholesterol/PTCH2 -0.155 0.185 -9999.0 0.0 -0.391 60.0 60.0 SHH Np/Cholesterol/Megalin -0.189 0.202 -9999.0 0.0 -0.366 95.0 95.0 SHH -0.186 0.243 -9999.0 0.0 -0.457 79.0 79.0 catabolic process -0.296 0.252 -9999.0 0.0 -0.538 80.0 80.0 SMO/Vitamin D3 -0.393 0.309 -9999.0 0.0 -0.639 92.0 92.0 SHH Np/Cholesterol/Hhip -0.219 0.245 -9999.0 0.0 -0.415 97.0 97.0 LRP2 -0.06 0.189 -9999.0 0.0 -0.554 23.0 23.0 receptor-mediated endocytosis -0.394 0.296 -9999.0 0.0 -0.623 95.0 95.0 SHH Np/Cholesterol/BOC -0.167 0.195 -9999.0 0.0 -0.4 63.0 63.0 SHH Np/Cholesterol/CDO -0.162 0.193 -9999.0 0.0 -0.4 61.0 61.0 mesenchymal cell differentiation 0.217 0.242 0.412 97.0 -9999.0 0.0 97.0 mol:Vitamin D3 -0.368 0.275 -9999.0 0.0 -0.564 99.0 99.0 IHH N/PTCH2 -0.233 0.186 -9999.0 0.0 -0.411 81.0 81.0 CDON -0.009 0.109 -9999.0 0.0 -0.599 6.0 6.0 IHH N/PTCH1 -0.299 0.256 -9999.0 0.0 -0.545 80.0 80.0 Megalin/LRPAP1 -0.05 0.134 -9999.0 0.0 -0.399 23.0 23.0 PTCH2 0.002 0.063 -9999.0 0.0 -0.49 3.0 3.0 SHH Np/Cholesterol -0.154 0.185 -9999.0 0.0 -0.359 79.0 79.0 PTCH1 -0.297 0.253 -9999.0 0.0 -0.54 80.0 80.0 HHIP -0.116 0.247 -9999.0 0.0 -0.587 39.0 39.0