Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.019 0.045 -9999.0 0.0 -0.279 4.0 4.0 epithelial cell differentiation -0.007 0.05 -9999.0 0.0 -0.344 4.0 4.0 CYFIP2 -0.016 0.124 -9999.0 0.0 -0.593 8.0 8.0 ENAH 0.043 0.056 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.029 0.146 -9999.0 0.0 -0.553 13.0 13.0 EPHA2 -0.0 0.084 -9999.0 0.0 -0.654 3.0 3.0 MYO6 0.022 0.058 -9999.0 0.0 -0.326 5.0 5.0 CTNNB1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.018 0.087 -9999.0 0.0 -0.411 8.0 8.0 AQP5 -0.17 0.216 -9999.0 0.0 -0.505 52.0 52.0 CTNND1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.024 0.051 -9999.0 0.0 -0.32 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.044 0.14 -9999.0 0.0 -0.324 31.0 31.0 EGF -0.151 0.267 -9999.0 0.0 -0.582 50.0 50.0 NCKAP1 0.007 0.049 -9999.0 0.0 -0.654 1.0 1.0 AQP3 -0.072 0.165 -9999.0 0.0 -0.523 20.0 20.0 cortical microtubule organization -0.007 0.05 -9999.0 0.0 -0.344 4.0 4.0 GO:0000145 0.023 0.049 -9999.0 0.0 -0.306 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.008 0.051 -9999.0 0.0 -0.348 4.0 4.0 MLLT4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.012 0.054 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.008 0.054 -9999.0 0.0 -0.368 4.0 4.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.033 0.053 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.008 0.037 -9999.0 0.0 -0.49 1.0 1.0 ZYX 0.022 0.058 -9999.0 0.0 -0.326 5.0 5.0 ARF6/GTP -0.007 0.049 -9999.0 0.0 -0.337 4.0 4.0 CDH1 -0.004 0.097 -9999.0 0.0 -0.654 4.0 4.0 EGFR/EGFR/EGF/EGF -0.097 0.146 -9999.0 0.0 -0.593 4.0 4.0 RhoA/GDP -0.007 0.047 -9999.0 0.0 -0.321 4.0 4.0 actin cytoskeleton organization 0.028 0.056 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer -0.017 0.132 -9999.0 0.0 -0.633 8.0 8.0 GIT1 0.007 0.049 -9999.0 0.0 -0.654 1.0 1.0 IGF1R -0.018 0.132 -9999.0 0.0 -0.634 8.0 8.0 IGF1 -0.087 0.22 -9999.0 0.0 -0.569 31.0 31.0 DIAPH1 -0.026 0.123 -9999.0 0.0 -0.642 7.0 7.0 Wnt receptor signaling pathway 0.007 0.05 0.344 4.0 -9999.0 0.0 4.0 RHOA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.012 0.054 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.028 0.057 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.03 0.05 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.012 0.059 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.007 0.043 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.045 0.142 -9999.0 0.0 -0.329 31.0 31.0 HGF/MET -0.038 0.103 -9999.0 0.0 -0.591 2.0 2.0 HGF -0.046 0.172 -9999.0 0.0 -0.563 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.019 0.045 -9999.0 0.0 -0.281 4.0 4.0 actin cable formation 0.053 0.056 -9999.0 0.0 -0.29 1.0 1.0 KIAA1543 0.007 0.1 -9999.0 0.0 -0.372 11.0 11.0 KIFC3 0.024 0.052 -9999.0 0.0 -0.325 4.0 4.0 NCK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.024 0.052 -9999.0 0.0 -0.325 4.0 4.0 NCK1/GIT1 -0.003 0.036 -9999.0 0.0 -0.483 1.0 1.0 mol:GDP -0.007 0.05 -9999.0 0.0 -0.344 4.0 4.0 EXOC4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.024 0.052 -9999.0 0.0 -0.325 4.0 4.0 PIP5K1C 0.024 0.052 -9999.0 0.0 -0.325 4.0 4.0 LIMA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.01 0.048 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.02 0.1 -9999.0 0.0 -0.627 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.064 0.132 -9999.0 0.0 -0.567 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.025 -9999.0 0.0 -0.344 1.0 1.0 MET -0.004 0.087 -9999.0 0.0 -0.523 5.0 5.0 PLEKHA7 0.007 0.105 -9999.0 0.0 -0.39 11.0 11.0 mol:GTP -0.008 0.053 -9999.0 0.0 -0.366 4.0 4.0 establishment of epithelial cell apical/basal polarity 0.044 0.049 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.019 0.045 -9999.0 0.0 -0.279 4.0 4.0 regulation of cell-cell adhesion 0.028 0.056 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.019 0.045 -9999.0 0.0 -0.281 4.0 4.0