E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.007 0.091 -9999.0 0.0 -0.435 6.0 6.0 KLHL20 0.01 0.064 0.182 1.0 -0.23 3.0 4.0 CYFIP2 0.02 0.054 -9999.0 0.0 -0.472 2.0 2.0 Rac1/GDP 0.016 0.074 0.257 1.0 -0.287 2.0 3.0 ENAH -0.015 0.104 -9999.0 0.0 -0.336 15.0 15.0 AP1M1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.012 0.041 -9999.0 0.0 -0.217 2.0 2.0 ABI1/Sra1/Nap1 -0.013 0.035 -9999.0 0.0 -0.16 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.048 0.053 -9999.0 0.0 -0.269 4.0 4.0 RAPGEF1 -0.006 0.096 0.223 1.0 -0.324 10.0 11.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.009 0.115 -9999.0 0.0 -0.337 18.0 18.0 CRK -0.011 0.106 -9999.0 0.0 -0.34 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.033 0.063 -9999.0 0.0 -0.35 4.0 4.0 alphaE/beta7 Integrin 0.034 0.03 -9999.0 0.0 -0.343 1.0 1.0 IQGAP1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.022 0.037 -9999.0 0.0 -0.472 1.0 1.0 Rap1/GTP/I-afadin 0.045 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.008 0.088 -9999.0 0.0 -0.352 9.0 9.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.014 0.022 -9999.0 0.0 -0.169 2.0 2.0 MLLT4 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.003 0.085 -9999.0 0.0 -0.262 16.0 16.0 PI3K -0.018 0.028 -9999.0 0.0 -0.215 2.0 2.0 ARF6 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.023 0.068 -9999.0 0.0 -0.411 4.0 4.0 TIAM1 -0.02 0.146 -9999.0 0.0 -0.472 17.0 17.0 E-cadherin(dimer)/Ca2+ 0.046 0.045 -9999.0 0.0 -0.255 3.0 3.0 AKT1 -0.003 0.035 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.016 0.063 -9999.0 0.0 -0.472 3.0 3.0 RhoA/GDP 0.02 0.07 0.257 1.0 -0.284 2.0 3.0 actin cytoskeleton organization 0.01 0.051 0.175 2.0 -0.167 3.0 5.0 CDC42/GDP 0.018 0.074 0.257 1.0 -0.284 2.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.005 0.053 -9999.0 0.0 -0.324 4.0 4.0 ITGB7 0.023 0.038 -9999.0 0.0 -0.472 1.0 1.0 RAC1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.048 -9999.0 0.0 -0.271 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.04 -9999.0 0.0 -0.25 3.0 3.0 mol:GDP 0.004 0.078 0.263 1.0 -0.325 2.0 3.0 CDC42/GTP/IQGAP1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.017 0.052 -9999.0 0.0 -0.472 2.0 2.0 p120 catenin/RhoA/GDP 0.027 0.071 0.259 1.0 -0.292 2.0 3.0 RAC1/GTP/IQGAP1 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.004 0.034 0.118 2.0 -0.239 1.0 3.0 NME1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.017 0.108 -9999.0 0.0 -0.332 17.0 17.0 regulation of cell-cell adhesion 0.006 0.034 -9999.0 0.0 -0.193 2.0 2.0 WASF2 0.003 0.029 0.082 1.0 -0.127 1.0 2.0 Rap1/GTP 0.019 0.055 -9999.0 0.0 -0.239 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.067 -9999.0 0.0 -0.294 5.0 5.0 CCND1 0.004 0.041 0.135 2.0 -0.3 1.0 3.0 VAV2 0.004 0.108 -9999.0 0.0 -0.431 4.0 4.0 RAP1/GDP 0.027 0.062 -9999.0 0.0 -0.249 2.0 2.0 adherens junction assembly -0.016 0.105 -9999.0 0.0 -0.322 17.0 17.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.046 0.071 -9999.0 0.0 -0.281 5.0 5.0 E-cadherin/beta catenin 0.001 0.05 -9999.0 0.0 -0.322 4.0 4.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.017 0.104 -9999.0 0.0 -0.322 17.0 17.0 PIK3CA 0.019 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.018 0.075 -9999.0 0.0 -0.325 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.038 0.047 -9999.0 0.0 -0.294 3.0 3.0 ITGAE 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.01 0.117 -9999.0 0.0 -0.344 18.0 18.0