Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.152 0.275 0.313 1.0 -0.571 47.0 48.0 IHH -0.083 0.235 -9999.0 0.0 -0.493 39.0 39.0 SHH Np/Cholesterol/GAS1 -0.081 0.153 -9999.0 0.0 -0.283 63.0 63.0 LRPAP1 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.081 0.152 0.281 63.0 -9999.0 0.0 63.0 SMO/beta Arrestin2 -0.177 0.267 -9999.0 0.0 -0.515 52.0 52.0 SMO -0.191 0.27 -9999.0 0.0 -0.508 60.0 60.0 AKT1 -0.087 0.174 -9999.0 0.0 -0.555 13.0 13.0 ARRB2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.016 0.076 -9999.0 0.0 -0.472 4.0 4.0 ADRBK1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.187 0.265 -9999.0 0.0 -0.499 60.0 60.0 STIL -0.157 0.196 0.208 2.0 -0.461 33.0 35.0 DHH N/PTCH2 0.021 0.078 -9999.0 0.0 -0.342 8.0 8.0 DHH N/PTCH1 -0.108 0.193 -9999.0 0.0 -0.326 61.0 61.0 PIK3CA 0.019 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.002 0.102 -9999.0 0.0 -0.472 8.0 8.0 PTHLH -0.256 0.414 -9999.0 0.0 -0.884 49.0 49.0 determination of left/right symmetry -0.187 0.265 -9999.0 0.0 -0.499 60.0 60.0 PIK3R1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.253 0.409 -9999.0 0.0 -0.872 49.0 49.0 IHH N/Hhip -0.072 0.208 0.2 8.0 -0.377 51.0 59.0 DHH N/Hhip -0.018 0.151 -9999.0 0.0 -0.362 28.0 28.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.187 0.265 -9999.0 0.0 -0.499 60.0 60.0 pancreas development -0.027 0.168 -9999.0 0.0 -0.471 22.0 22.0 HHAT -0.001 0.107 -9999.0 0.0 -0.472 9.0 9.0 PI3K 0.026 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.013 0.15 -9999.0 0.0 -0.472 17.0 17.0 somite specification -0.187 0.265 -9999.0 0.0 -0.499 60.0 60.0 SHH Np/Cholesterol/PTCH1 -0.156 0.202 -9999.0 0.0 -0.369 60.0 60.0 SHH Np/Cholesterol/PTCH2 -0.059 0.135 -9999.0 0.0 -0.276 49.0 49.0 SHH Np/Cholesterol/Megalin -0.068 0.151 -9999.0 0.0 -0.283 56.0 56.0 SHH -0.096 0.16 -9999.0 0.0 -0.354 49.0 49.0 catabolic process -0.115 0.202 -9999.0 0.0 -0.329 77.0 77.0 SMO/Vitamin D3 -0.185 0.248 0.288 2.0 -0.488 51.0 53.0 SHH Np/Cholesterol/Hhip -0.085 0.178 0.21 1.0 -0.323 59.0 60.0 LRP2 0.007 0.113 -9999.0 0.0 -0.472 9.0 9.0 receptor-mediated endocytosis -0.2 0.246 -9999.0 0.0 -0.517 49.0 49.0 SHH Np/Cholesterol/BOC -0.061 0.14 -9999.0 0.0 -0.28 49.0 49.0 SHH Np/Cholesterol/CDO -0.061 0.14 -9999.0 0.0 -0.283 49.0 49.0 mesenchymal cell differentiation 0.085 0.177 0.321 59.0 -0.207 1.0 60.0 mol:Vitamin D3 -0.147 0.213 0.257 3.0 -0.381 55.0 58.0 IHH N/PTCH2 -0.036 0.152 0.2 1.0 -0.307 37.0 38.0 CDON 0.015 0.064 -9999.0 0.0 -0.472 3.0 3.0 IHH N/PTCH1 -0.095 0.222 -9999.0 0.0 -0.331 78.0 78.0 Megalin/LRPAP1 0.02 0.086 -9999.0 0.0 -0.343 9.0 9.0 PTCH2 0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.066 0.128 -9999.0 0.0 -0.272 49.0 49.0 PTCH1 -0.116 0.202 -9999.0 0.0 -0.33 77.0 77.0 HHIP -0.027 0.168 -9999.0 0.0 -0.472 22.0 22.0