Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	36.0	1881.0	52.0	-0.256	0.085	1000.0	-1000.0	-0.043	-1000.0
FOXA2 and FOXA3 transcription factor networks	35.0	1618.0	46.0	-0.45	0.025	1000.0	-1000.0	-0.086	-1000.0
Ephrin B reverse signaling	23.0	1115.0	48.0	-0.161	0.024	1000.0	-1000.0	-0.032	-1000.0
LPA receptor mediated events	20.0	2056.0	102.0	-0.151	0.031	1000.0	-1000.0	-0.069	-1000.0
IL4-mediated signaling events	19.0	1746.0	91.0	-0.525	0.312	1000.0	-1000.0	-0.126	-1000.0
Glucocorticoid receptor regulatory network	18.0	2054.0	114.0	-0.495	0.194	1000.0	-1000.0	-0.053	-1000.0
p75(NTR)-mediated signaling	17.0	2166.0	125.0	-0.088	0.066	1000.0	-1000.0	-0.064	-1000.0
TCGA08_retinoblastoma	17.0	141.0	8.0	-0.059	0.073	1000.0	-1000.0	-0.004	-1000.0
IL23-mediated signaling events	17.0	1074.0	60.0	-0.288	0.025	1000.0	-1000.0	-0.096	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	16.0	1118.0	68.0	-0.212	0.09	1000.0	-1000.0	-0.071	-1000.0
Endothelins	15.0	1468.0	96.0	-0.105	0.038	1000.0	-1000.0	-0.046	-1000.0
Osteopontin-mediated events	14.0	564.0	38.0	-0.087	0.032	1000.0	-1000.0	-0.037	-1000.0
HIF-1-alpha transcription factor network	14.0	1134.0	76.0	-0.079	0.042	1000.0	-1000.0	-0.06	-1000.0
S1P5 pathway	14.0	243.0	17.0	-0.09	0.067	1000.0	-1000.0	-0.014	-1000.0
IGF1 pathway	14.0	835.0	57.0	-0.045	0.047	1000.0	-1000.0	-0.048	-1000.0
Fc-epsilon receptor I signaling in mast cells	13.0	1325.0	97.0	-0.082	0.029	1000.0	-1000.0	-0.061	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	12.0	408.0	34.0	-0.021	0.033	1000.0	-1000.0	-0.032	-1000.0
Ephrin A  reverse signaling	12.0	86.0	7.0	-0.034	0.003	1000.0	-1000.0	-0.015	-1000.0
Signaling mediated by p38-alpha and p38-beta	12.0	548.0	44.0	-0.051	0.033	1000.0	-1000.0	-0.023	-1000.0
TCR signaling in naïve CD8+ T cells	12.0	1180.0	93.0	-0.058	0.036	1000.0	-1000.0	-0.042	-1000.0
EPHB forward signaling	12.0	1101.0	85.0	-0.066	0.079	1000.0	-1000.0	-0.061	-1000.0
EGFR-dependent Endothelin signaling events	12.0	258.0	21.0	-0.051	0.036	1000.0	-1000.0	-0.038	-1000.0
Syndecan-1-mediated signaling events	11.0	377.0	34.0	-0.051	0.025	1000.0	-1000.0	-0.034	-1000.0
BMP receptor signaling	11.0	964.0	81.0	-0.097	0.044	1000.0	-1000.0	-0.038	-1000.0
Reelin signaling pathway	11.0	648.0	56.0	-0.038	0.062	1000.0	-1000.0	-0.034	-1000.0
BCR signaling pathway	11.0	1149.0	99.0	-0.101	0.033	1000.0	-1000.0	-0.046	-1000.0
Thromboxane A2 receptor signaling	10.0	1129.0	105.0	-0.045	0.029	1000.0	-1000.0	-0.036	-1000.0
Glypican 1 network	10.0	512.0	48.0	-0.078	0.032	1000.0	-1000.0	-0.029	-1000.0
S1P4 pathway	10.0	255.0	25.0	-0.09	0.042	1000.0	-1000.0	-0.02	-1000.0
IL12-mediated signaling events	9.0	853.0	87.0	-0.101	0.045	1000.0	-1000.0	-0.072	-1000.0
Visual signal transduction: Cones	9.0	359.0	38.0	-0.065	0.039	1000.0	-1000.0	-0.025	-1000.0
Wnt signaling	9.0	65.0	7.0	-0.021	0.022	1000.0	-1000.0	-0.013	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	9.0	1135.0	120.0	-0.093	0.061	1000.0	-1000.0	-0.049	-1000.0
Visual signal transduction: Rods	9.0	496.0	52.0	-0.072	0.037	1000.0	-1000.0	-0.038	-1000.0
Noncanonical Wnt signaling pathway	8.0	221.0	26.0	-0.04	0.025	1000.0	-1000.0	-0.039	-1000.0
Arf6 signaling events	8.0	532.0	62.0	-0.032	0.052	1000.0	-1000.0	-0.03	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	693.0	82.0	-0.031	0.032	1000.0	-1000.0	-0.048	-1000.0
Retinoic acid receptors-mediated signaling	8.0	464.0	58.0	-0.061	0.046	1000.0	-1000.0	-0.047	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	271.0	31.0	-0.076	0.025	1000.0	-1000.0	-0.044	-1000.0
Sphingosine 1-phosphate (S1P) pathway	7.0	203.0	28.0	-0.09	0.038	1000.0	-1000.0	-0.021	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	397.0	54.0	-0.043	0.035	1000.0	-1000.0	-0.046	-1000.0
Hedgehog signaling events mediated by Gli proteins	7.0	477.0	65.0	-0.333	0.059	1000.0	-1000.0	-0.054	-1000.0
EPO signaling pathway	7.0	402.0	55.0	-0.002	0.052	1000.0	-1000.0	-0.042	-1000.0
amb2 Integrin signaling	7.0	623.0	82.0	-0.062	0.035	1000.0	-1000.0	-0.038	-1000.0
IL1-mediated signaling events	7.0	435.0	62.0	-0.047	0.042	1000.0	-1000.0	-0.044	-1000.0
S1P1 pathway	7.0	252.0	36.0	-0.065	0.024	1000.0	-1000.0	-0.037	-1000.0
Canonical Wnt signaling pathway	7.0	406.0	51.0	-0.05	0.197	1000.0	-1000.0	-0.055	-1000.0
Effects of Botulinum toxin	7.0	204.0	26.0	-0.048	0.024	1000.0	-1000.0	-0.012	-1000.0
Plasma membrane estrogen receptor signaling	7.0	627.0	86.0	-0.091	0.038	1000.0	-1000.0	-0.047	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.006	0.006	1000.0	-1000.0	-0.012	-1000.0
Caspase cascade in apoptosis	6.0	486.0	74.0	-0.061	0.042	1000.0	-1000.0	-0.037	-1000.0
Nectin adhesion pathway	6.0	420.0	63.0	-0.029	0.054	1000.0	-1000.0	-0.061	-1000.0
Ceramide signaling pathway	6.0	492.0	76.0	-0.032	0.064	1000.0	-1000.0	-0.032	-1000.0
FAS signaling pathway (CD95)	6.0	318.0	47.0	-0.066	0.035	1000.0	-1000.0	-0.033	-1000.0
Integrins in angiogenesis	6.0	510.0	84.0	-0.055	0.054	1000.0	-1000.0	-0.047	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	485.0	74.0	-0.108	0.057	1000.0	-1000.0	-0.057	-1000.0
Syndecan-4-mediated signaling events	6.0	463.0	67.0	-0.032	0.034	1000.0	-1000.0	-0.039	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	560.0	88.0	-0.052	0.034	1000.0	-1000.0	-0.065	-1000.0
FOXM1 transcription factor network	6.0	323.0	51.0	-0.046	0.075	1000.0	-1000.0	-0.098	-1000.0
ErbB2/ErbB3 signaling events	5.0	378.0	65.0	-0.033	0.036	1000.0	-1000.0	-0.064	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	87.0	17.0	-0.034	0.051	1000.0	-1000.0	-0.039	-1000.0
Syndecan-2-mediated signaling events	5.0	410.0	69.0	-0.013	0.038	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by PTP1B	5.0	447.0	76.0	-0.045	0.032	1000.0	-1000.0	-0.04	-1000.0
IFN-gamma pathway	5.0	348.0	68.0	-0.042	0.045	1000.0	-1000.0	-0.044	-1000.0
IL27-mediated signaling events	5.0	277.0	51.0	-0.133	0.044	1000.0	-1000.0	-0.048	-1000.0
S1P3 pathway	5.0	245.0	42.0	-0.033	0.036	1000.0	-1000.0	-0.038	-1000.0
PDGFR-beta signaling pathway	5.0	520.0	97.0	-0.056	0.051	1000.0	-1000.0	-0.054	-1000.0
Regulation of Androgen receptor activity	5.0	392.0	70.0	-0.282	0.043	1000.0	-1000.0	-0.048	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	92.0	17.0	-0.016	0.036	1000.0	-1000.0	-0.022	-1000.0
LPA4-mediated signaling events	4.0	51.0	12.0	-0.033	0.017	1000.0	-1000.0	-0.022	-1000.0
Cellular roles of Anthrax toxin	4.0	183.0	39.0	-0.02	0.024	1000.0	-1000.0	-0.017	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	413.0	85.0	-0.02	0.035	1000.0	-1000.0	-0.044	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	287.0	61.0	-0.05	0.066	1000.0	-1000.0	-0.042	-1000.0
mTOR signaling pathway	4.0	232.0	53.0	-0.02	0.05	1000.0	-1000.0	-0.033	-1000.0
ceramide signaling pathway	4.0	212.0	49.0	-0.016	0.043	1000.0	-1000.0	-0.034	-1000.0
HIF-2-alpha transcription factor network	4.0	204.0	43.0	-0.057	0.058	1000.0	-1000.0	-0.05	-1000.0
TCGA08_p53	4.0	29.0	7.0	-0.014	0.024	1000.0	-1000.0	-0.011	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	68.0	15.0	-0.022	0.024	1000.0	-1000.0	-0.026	-1000.0
Syndecan-3-mediated signaling events	4.0	145.0	35.0	-0.005	0.066	1000.0	-1000.0	-0.023	-1000.0
IL2 signaling events mediated by PI3K	4.0	238.0	58.0	-0.076	0.052	1000.0	-1000.0	-0.039	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	195.0	45.0	-0.028	0.044	1000.0	-1000.0	-0.05	-1000.0
Glypican 2 network	4.0	19.0	4.0	0.01	0.02	1000.0	-1000.0	0.008	-1000.0
Nongenotropic Androgen signaling	4.0	230.0	52.0	-0.032	0.044	1000.0	-1000.0	-0.03	-1000.0
Class I PI3K signaling events	4.0	312.0	73.0	-0.02	0.034	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	4.0	368.0	78.0	-0.047	0.032	1000.0	-1000.0	-0.049	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	491.0	136.0	-0.282	0.058	1000.0	-1000.0	-0.046	-1000.0
Coregulation of Androgen receptor activity	3.0	301.0	76.0	-0.205	0.047	1000.0	-1000.0	-0.024	-1000.0
ErbB4 signaling events	3.0	208.0	69.0	-0.078	0.041	1000.0	-1000.0	-0.042	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	200.0	52.0	-0.045	0.066	1000.0	-1000.0	-0.046	-1000.0
Regulation of p38-alpha and p38-beta	3.0	185.0	54.0	-0.039	0.054	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	466.0	125.0	-0.031	0.046	1000.0	-1000.0	-0.047	-1000.0
TCGA08_rtk_signaling	3.0	90.0	26.0	-0.049	0.083	1000.0	-1000.0	-0.005	-1000.0
IL6-mediated signaling events	3.0	280.0	75.0	-0.057	0.046	1000.0	-1000.0	-0.057	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	281.0	76.0	-0.02	0.05	1000.0	-1000.0	-0.051	-1000.0
Arf6 downstream pathway	2.0	103.0	43.0	-0.025	0.043	1000.0	-1000.0	-0.03	-1000.0
PLK1 signaling events	2.0	254.0	85.0	-0.017	0.044	1000.0	-1000.0	-0.031	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	184.0	68.0	-0.029	0.048	1000.0	-1000.0	-0.035	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	98.0	37.0	-0.02	0.056	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class III	2.0	91.0	40.0	-0.047	0.047	1000.0	-1000.0	-0.032	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	191.0	83.0	-0.042	0.046	1000.0	-1000.0	-0.031	-1000.0
Regulation of Telomerase	2.0	273.0	102.0	-0.038	0.056	1000.0	-1000.0	-0.047	-1000.0
Insulin Pathway	2.0	162.0	74.0	-0.032	0.055	1000.0	-1000.0	-0.042	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	91.0	33.0	-0.016	0.059	1000.0	-1000.0	-0.024	-1000.0
E-cadherin signaling in keratinocytes	2.0	116.0	43.0	-0.032	0.043	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling events	2.0	12.0	5.0	0.016	0.032	1000.0	-1000.0	0.013	-1000.0
p38 MAPK signaling pathway	2.0	96.0	44.0	-0.022	0.053	1000.0	-1000.0	-0.028	-1000.0
Aurora B signaling	2.0	147.0	67.0	-0.089	0.073	1000.0	-1000.0	-0.036	-1000.0
Canonical NF-kappaB pathway	1.0	55.0	39.0	-0.007	0.05	1000.0	-1000.0	-0.024	-1000.0
BARD1 signaling events	1.0	61.0	57.0	-0.044	0.062	1000.0	-1000.0	-0.042	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	0.02	0.031	1000.0	-1000.0	0.01	-1000.0
Aurora A signaling	1.0	106.0	60.0	-0.024	0.048	1000.0	-1000.0	-0.02	-1000.0
TRAIL signaling pathway	1.0	73.0	48.0	-0.01	0.075	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by HDAC Class I	1.0	151.0	104.0	-0.047	0.061	1000.0	-1000.0	-0.029	-1000.0
FoxO family signaling	1.0	127.0	64.0	-0.068	0.056	1000.0	-1000.0	-0.059	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	48.0	36.0	-0.043	0.047	1000.0	-1000.0	-0.037	-1000.0
Atypical NF-kappaB pathway	1.0	39.0	31.0	-0.012	0.026	1000.0	-1000.0	-0.025	-1000.0
IL2 signaling events mediated by STAT5	1.0	43.0	22.0	-0.007	0.034	1000.0	-1000.0	-0.043	-1000.0
VEGFR1 specific signals	1.0	73.0	56.0	-0.023	0.046	1000.0	-1000.0	-0.047	-1000.0
Rapid glucocorticoid signaling	1.0	24.0	20.0	-0.011	0.029	1000.0	-1000.0	-0.013	-1000.0
Signaling events mediated by PRL	1.0	62.0	34.0	-0.035	0.039	1000.0	-1000.0	-0.039	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	0.004	0.039	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class II	0.0	73.0	75.0	-0.026	0.063	1000.0	-1000.0	-0.029	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.014	-1000.0	1000.0	-1000.0	-0.027	-1000.0
Circadian rhythm pathway	0.0	17.0	22.0	-0.005	0.045	1000.0	-1000.0	-0.04	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.0	0.042	1000.0	-1000.0	-0.019	-1000.0
Insulin-mediated glucose transport	0.0	24.0	32.0	-0.012	0.046	1000.0	-1000.0	-0.034	-1000.0
PDGFR-alpha signaling pathway	0.0	30.0	44.0	-0.049	0.056	1000.0	-1000.0	-0.038	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.016	0.053	1000.0	-1000.0	-0.033	-1000.0
Arf6 trafficking events	0.0	52.0	71.0	-0.041	0.044	1000.0	-1000.0	-0.038	-1000.0
Arf1 pathway	0.0	22.0	54.0	-0.008	0.034	1000.0	-1000.0	-0.021	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	-0.0	0.064	1000.0	-1000.0	-0.0	-1000.0
Total	844	54162	7203	-8.67937991787	-993.668818116	131000	-131000	-5.0290266843	-131000