rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), BCL2(2), EGFR(92), IGF1R(3), POLR2A(2), PRKCA(1), RB1(24), TEP1(4), TERT(3), TNKS(1), TP53(96), XRCC5(1) 12019002 230 153 143 15 43 63 15 59 49 1 <1.00e-15 <1.00e-15 <3.24e-14 2 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 CRKL(1), DOCK1(2), ELK1(2), FOS(1), HGF(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAP4K1(2), MAPK1(2), MAPK3(1), MET(3), PAK1(1), PIK3CA(33), PIK3R1(33), PTEN(90), PTK2B(3), PTPN11(4), PXN(1), RAF1(1), SOS1(3), SRC(2), STAT3(1) 18829475 191 149 163 5 21 37 25 37 71 0 <1.00e-15 <1.00e-15 <3.24e-14 3 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(1), INPPL1(3), ITGB1BP3(1), MIOX(1), OCRL(2), PI4KA(1), PI4KB(2), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), PTEN(90), SYNJ2(3) 31664122 178 142 156 19 29 35 22 35 57 0 3.22e-08 <1.00e-15 <3.24e-14 4 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A1(1), EIF4B(1), EIF4G1(1), EIF4G3(1), PIK3CA(33), PIK3R1(33), PTEN(90), TSC2(3) 11773777 164 138 136 2 12 33 21 30 68 0 3.77e-15 <1.00e-15 <3.24e-14 5 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(1), ASAH1(1), BRAF(6), CCL13(1), CCL15(1), DAG1(2), EGFR(92), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PIK3CA(33), PIK3R1(33), PITX2(3), RAF1(1), SRC(2) 22860021 195 137 132 16 24 66 18 53 34 0 1.14e-12 <1.00e-15 <3.24e-14 6 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), MAPK1(2), MAPK3(1), PIK3CA(33), PTEN(90), PTK2B(3), SOS1(3) 8656996 133 118 111 3 13 30 19 21 50 0 2.03e-12 <1.00e-15 <3.24e-14 7 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(2), ATM(4), ATR(4), CCNA1(1), CCNE1(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), GSK3B(1), RB1(24), SKP2(1), TFDP1(1), TP53(96) 12757976 141 103 102 4 30 18 15 33 44 1 5.53e-13 <1.00e-15 <3.24e-14 8 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(4), ATR(4), BRCA1(4), BRCA2(4), CHEK1(3), FANCD2(2), MRE11A(1), RAD50(1), TP53(96) 18721101 119 98 82 5 34 19 17 29 20 0 8.85e-10 <1.00e-15 <3.24e-14 9 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNG(2), IFNGR1(1), IFNGR2(3), IKBKB(1), JAK2(1), NFKB1(1), NFKBIA(1), RB1(24), TNFRSF1A(1), TNFRSF1B(1), TP53(96), USH1C(1), WT1(2) 7833614 135 98 96 3 31 16 15 30 42 1 3.30e-14 <1.00e-15 <3.24e-14 10 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(2), ATM(4), BRCA1(4), CDKN1A(1), CHEK1(3), MDM2(2), MRE11A(1), NFKB1(1), NFKBIA(1), RAD50(1), RBBP8(1), TP53(96) 12680905 117 95 80 6 36 17 14 28 22 0 5.63e-09 <1.00e-15 <3.24e-14 11 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(4), CHEK1(3), RB1(24), TP53(96), WEE1(1), YWHAH(1) 7486740 129 95 90 2 30 15 14 27 42 1 1.07e-12 <1.00e-15 <3.24e-14 12 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(4), ATR(4), CHEK1(3), TP53(96), YWHAH(1) 6793424 108 90 71 3 30 17 15 26 20 0 3.07e-09 <1.00e-15 <3.24e-14 13 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(2), SP1(1), SP3(1), TP53(96), WT1(2) 2998025 102 83 65 3 30 17 11 25 19 0 1.64e-11 <1.00e-15 <3.24e-14 14 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), INSR(2), IRS1(4), JAK2(1), MAP2K1(1), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), PTPN6(1), RAF1(1), RPS6KA1(1), SOCS1(1), SOS1(3), SRF(1) 14036693 93 81 82 9 12 16 16 19 30 0 0.000246 <1.00e-15 <3.24e-14 15 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCL2(2), CRKL(1), FOS(1), JAK2(1), MAP2K1(1), MAP3K1(6), MAPK3(1), PIK3CA(33), PIK3R1(33), RAF1(1), SOS1(3), STAT1(2) 11907694 86 78 73 4 8 16 14 18 30 0 3.59e-06 <1.00e-15 <3.24e-14 16 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), ELK1(2), FOS(1), MAP2K1(1), MAPK3(1), PIK3CA(33), PIK3R1(33), PLCG1(6), RAF1(1), SOS1(3) 8135723 82 73 71 1 8 13 14 18 29 0 5.57e-08 <1.00e-15 <3.24e-14 17 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), IGF1R(3), IRS1(4), MAP2K1(1), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), RAF1(1), SOS1(3), YWHAH(1) 8023891 83 72 72 4 7 13 16 17 30 0 1.45e-05 <1.00e-15 <3.24e-14 18 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3E(2), CD3G(1), CD86(2), HLA-DRA(1), PIK3CA(33), PIK3R1(33), PTPN11(4) 5411109 77 69 66 2 9 12 12 17 27 0 3.25e-06 <1.00e-15 <3.24e-14 19 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), ITGB1(1), KLRC1(1), KLRC2(4), KLRD1(1), MAP2K1(1), MAPK3(1), PAK1(1), PIK3CA(33), PIK3R1(33), PTK2B(3), PTPN6(1), VAV1(4) 7905108 85 69 74 6 10 12 14 18 31 0 0.000161 <1.00e-15 <3.24e-14 20 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), CBL(1), CDKN2A(2), FLOT1(1), GSK3B(1), INPPL1(3), IRS1(4), IRS4(2), LNPEP(2), MAPK1(2), MAPK3(1), PARD3(1), PIK3CA(33), PIK3R1(33), PPYR1(1), PTEN(90), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SORBS1(2), SOS1(3), YWHAE(2), YWHAH(1) 25218068 192 153 164 10 15 37 27 36 77 0 4.22e-12 1.44e-15 4.45e-14 21 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(33), PIK3R1(33), PLCB1(1), PLCG1(6), PRKCA(1), VAV1(4) 5434302 79 70 68 3 8 13 13 16 29 0 8.88e-06 1.55e-15 4.56e-14 22 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(1), BTK(1), CDKN2A(2), GSK3B(1), IARS(3), INPP5D(3), PIK3CA(33), PTEN(90), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TEC(1), YWHAE(2), YWHAH(1) 15287521 147 128 125 6 15 36 19 25 52 0 6.52e-12 1.78e-15 4.97e-14 23 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDKN1A(1), CDKN1B(1), CDKN2A(2), MDM2(2), PRB1(1), TP53(96) 3538102 103 83 66 2 30 16 12 24 21 0 3.37e-12 1.89e-15 5.00e-14 24 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 ATM(4), ATR(4), CASP9(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG1(2), CDKN1A(1), CDKN2A(2), CHEK1(3), DDB2(1), GADD45B(1), GTSE1(1), IGF1(2), MDM2(2), MDM4(1), PPM1D(1), PTEN(90), RPRM(1), RRM2(1), SERPINB5(1), SERPINE1(2), SESN1(1), SESN3(1), SFN(1), THBS1(2), TP53(96), TSC2(3) 27824014 232 162 178 14 41 44 28 50 69 0 1.11e-15 2.11e-15 5.00e-14 25 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(1), EGF(3), EGFR(92), MET(3), PDGFRA(14), PRKCA(1), SRC(2) 8244530 117 88 68 12 12 50 6 42 7 0 3.18e-07 2.11e-15 5.00e-14 26 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), CASP9(1), CHUK(1), GH1(1), NFKB1(1), NFKBIA(1), PIK3CA(33), PIK3R1(33), YWHAH(1) 6000301 73 65 62 2 6 13 12 15 27 0 4.24e-06 2.22e-15 5.00e-14 27 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCNE1(1), CDKN1A(1), CDKN1B(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(1), PIK3CA(33), PIK3R1(33), RAF1(1), RB1(24), TFDP1(1) 8613419 102 87 89 2 7 14 14 17 49 1 5.98e-09 2.33e-15 5.00e-14 28 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(3), EGFR(92), MAP2K1(1), MAP3K1(6), NCOR2(2), RXRA(3), THRA(1) 7394439 108 85 58 14 13 49 3 36 7 0 4.74e-06 2.44e-15 5.00e-14 29 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), BTK(1), CD19(1), CDKN2A(2), FLOT1(1), ITPR1(5), ITPR2(3), ITPR3(5), LYN(2), NR0B2(1), PIK3CA(33), PITX2(3), PLCG2(3), PREX1(5), PTEN(90), PTPRC(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), TEC(1), VAV1(4) 23616977 167 138 145 16 26 40 21 23 57 0 1.82e-09 2.55e-15 5.00e-14 30 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2S2(1), EIF2S3(2), GSK3B(1), IGF1(2), IGF1R(3), INPPL1(3), PIK3CA(33), PIK3R1(33), PTEN(90) 8375666 169 142 141 3 11 32 23 31 72 0 2.02e-14 2.66e-15 5.00e-14 31 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(3), AKT1(1), CAMK2A(1), CREB1(1), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RPS6KA1(1), RPS6KA5(1), SOS1(3) 12403154 83 74 72 1 13 14 13 16 27 0 4.08e-08 2.78e-15 5.00e-14 32 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(3), F2(1), F2RL3(2), GNB1(1), MAP3K7(3), PIK3CA(33), PIK3R1(33), PLCB1(1), PPP1R12B(1), PRKCA(1), PTK2B(3), ROCK1(2) 11028541 84 70 73 3 13 14 12 15 30 0 1.06e-06 2.78e-15 5.00e-14 33 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), GH1(1), IGF1(2), IGF1R(3), PIK3CA(33), PIK3R1(33) 5644334 73 66 62 3 5 13 12 16 27 0 2.47e-05 2.78e-15 5.00e-14 34 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(10), AKT1(1), ATM(4), CDKN1A(1), CSNK1D(1), MDM2(2), NQO1(1), TP53(96) 8872453 116 93 79 5 35 19 13 26 23 0 3.04e-10 2.89e-15 5.00e-14 35 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(2), CDKN2A(2), MDM2(2), PIK3CA(33), PIK3R1(33), POLR1A(2), POLR1B(1), RB1(24), TP53(96) 8560931 195 135 145 2 36 27 24 38 69 1 <1.00e-15 3.00e-15 5.00e-14 36 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(1), CDKN1B(1), CDKN2A(2), CREB1(1), GSK3B(1), IGF1(2), INPPL1(3), IRS1(4), IRS4(2), MET(3), PAK1(1), PAK4(2), PAK7(1), PARD3(1), PIK3CA(33), PREX1(5), PTEN(90), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TSC2(3), YWHAE(2), YWHAH(1) 32834817 167 139 145 13 21 34 25 28 59 0 1.55e-09 3.11e-15 5.00e-14 37 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(92), ELK1(2), GNB1(1), IGF1R(3), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PDGFRA(14), PTPRR(3), RAF1(1), RPS6KA1(1), RPS6KA5(1), SOS1(3), SRC(2), STAT3(1) 14150647 129 101 80 12 16 54 8 43 8 0 9.16e-09 3.11e-15 5.00e-14 38 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B1(1), EIF2S2(1), EIF2S3(2), ELAVL1(1), FLT1(5), FLT4(2), KDR(8), NOS3(3), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), PXN(1) 14536312 97 82 86 9 16 17 14 20 30 0 4.98e-05 3.11e-15 5.00e-14 39 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(3), EGFR(92), NRG1(2) 4366865 97 79 49 11 10 44 2 36 5 0 1.88e-05 3.33e-15 5.00e-14 40 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), CREB1(1), MAPK1(2), MAPK3(1), MAPK7(1), MEF2A(2), MEF2D(1), NTRK1(1), PIK3CA(33), PIK3R1(33), PLCG1(6), RPS6KA1(1) 8085911 83 73 72 4 9 16 13 16 29 0 3.60e-06 3.33e-15 5.00e-14 41 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC2(1), PAK1(1), PDGFRA(14), PIK3CA(33), PIK3R1(33) 5669242 82 71 70 2 5 16 14 17 30 0 1.25e-06 3.33e-15 5.00e-14 42 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT1(1), ANGPTL2(1), ARHGAP4(2), ARHGEF11(2), BTK(1), CFL2(1), GDI1(1), INPPL1(3), ITPR1(5), ITPR2(3), ITPR3(5), MYLK(2), PAK1(1), PAK4(2), PAK7(1), PIK3CA(33), PIK3CG(7), PIK3R1(33), PITX2(3), PTEN(90), ROCK1(2), ROCK2(1), RPS4X(1) 30046319 201 158 173 16 30 43 23 28 77 0 5.18e-11 3.44e-15 5.05e-14 43 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 MAP3K1(6), MYLK(2), NCF2(2), PAK1(1), PDGFRA(14), PIK3CA(33), PIK3R1(33), PLD1(1), PPP1R12B(1), RALBP1(1), TRIO(2), VAV1(4) 14857186 100 80 86 9 8 21 18 22 31 0 5.36e-05 3.66e-15 5.25e-14 44 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), CDKN1B(1), ITGB1(1), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), PTEN(90), SOS1(3) 8230675 165 137 137 0 11 33 24 29 68 0 <1.00e-15 4.00e-15 5.47e-14 45 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(3), AKT1(1), ASAH1(1), GNB1(1), ITGAV(1), ITGB3(1), MAPK1(2), MAPK3(1), PDGFRA(14), PIK3CA(33), PIK3R1(33), PLCB1(1), PRKCA(1), SRC(2) 11670015 95 78 83 3 11 21 15 19 29 0 3.87e-08 4.00e-15 5.47e-14 46 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), CREB1(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), NFKB1(1), PIK3CA(33), PIK3R1(33), RB1(24), SP1(1) 8273264 107 91 92 4 10 17 13 15 51 1 1.04e-07 4.11e-15 5.47e-14 47 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(3), INPP5E(1), INPPL1(3), ITGB1BP3(1), ITPR1(5), ITPR2(3), ITPR3(5), OCRL(2), PI4KA(1), PI4KB(2), PIK3C2A(1), PIK3C2B(1), PIK3C2G(9), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), PRKCA(1), PRKCG(2), PTEN(90), SYNJ2(3) 53370502 264 179 236 27 54 48 30 50 82 0 5.44e-12 4.33e-15 5.47e-14 48 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(1), CALM1(1), GNB1(1), NFKB1(1), NOS3(3), NPPA(2), PIK3CA(33), PIK3R1(33), SYT1(1) 7695806 76 67 65 1 9 12 12 16 27 0 6.43e-07 4.33e-15 5.47e-14 49 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(2), CREBBP(4), EP300(1), FYN(1), IL7(1), IL7R(2), JAK1(2), JAK3(2), PIK3CA(33), PIK3R1(33), PTK2B(3) 11942668 84 76 73 7 9 15 13 15 32 0 0.000273 4.44e-15 5.47e-14 50 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A1(1), EIF4G1(1), EIF4G3(1), IRS1(4), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), PRKCA(1), PTEN(90) 11939951 168 138 140 4 13 33 23 29 70 0 2.17e-13 4.55e-15 5.47e-14 51 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), DAXX(3), PAX3(3), RB1(24), SP100(2), TNFRSF1A(1), TNFRSF1B(1), TP53(96) 8172721 134 96 95 5 31 18 13 28 43 1 1.99e-12 4.66e-15 5.47e-14 52 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 ATM(4), BCL2(2), CCNE1(1), CDKN1A(1), MDM2(2), RB1(24), TIMP3(1), TP53(96) 7728429 131 96 92 3 30 16 13 26 45 1 2.65e-12 4.77e-15 5.47e-14 53 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 GNB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), NFKB1(1), PIK3C2G(9), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), PTK2B(3), PXN(1), RAF1(1) 11827376 93 80 82 4 15 13 17 18 30 0 3.98e-07 4.77e-15 5.47e-14 54 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(2), AKT1(1), ATM(4), BCL2(2), BIRC2(1), BIRC3(1), CAPN1(2), CASP10(1), CASP9(1), CHUK(1), CSF2RB(4), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL3(1), IL3RA(2), IRAK1(2), IRAK2(1), IRAK3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NTRK1(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), RIPK1(1), TNFRSF1A(1), TNFSF10(2), TP53(96) 35749173 226 151 177 21 54 38 29 51 54 0 1.47e-11 4.88e-15 5.47e-14 55 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), ELK1(2), FOS(1), IGF1(2), IGF1R(3), IRS1(4), MAP2K1(1), MAPK3(1), PIK3CA(33), PIK3R1(33), PTPN11(4), RAF1(1), SOS1(3), SRF(1) 10528542 90 77 79 6 8 14 15 22 31 0 4.59e-05 4.88e-15 5.47e-14 56 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), CHRNG(1), MUSK(1), PIK3CA(33), PIK3R1(33), PTK2B(3), SRC(2), TERT(3), YWHAH(1) 6984862 78 71 67 2 10 13 12 15 28 0 5.00e-07 5.00e-15 5.50e-14 57 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(1), AGT(1), AGTR2(1), EGF(3), EGFR(92), FOS(1), NFKB1(1), PLCG1(6), PRKCA(1) 8708407 107 82 59 13 14 45 4 39 5 0 1.54e-06 5.11e-15 5.52e-14 58 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), ATM(4), BCL2(2), CASP9(1), PRKCA(1), PXN(1), STAT1(2), TP53(96) 11683717 108 89 71 2 30 16 13 26 23 0 1.18e-11 5.44e-15 5.77e-14 59 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 BCL2(2), BIRC2(1), BIRC3(1), CASP9(1), GZMB(2), MAP3K1(6), MCL1(1), MDM2(2), NFKB1(1), NFKBIA(1), PARP1(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF10(2), TP53(96), TRAF1(1) 15966939 121 93 82 9 34 20 15 29 23 0 3.17e-09 5.55e-15 5.77e-14 60 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), EIF2S2(1), NFKB1(1), NFKBIA(1), TP53(96) 4216169 100 82 63 2 30 15 12 24 19 0 7.02e-11 5.77e-15 5.77e-14 61 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(1), AXIN1(3), DVL1(1), FZD1(1), GSK3B(1), IRAK1(2), LBP(3), LY96(2), NFKB1(1), PIK3CA(33), PIK3R1(33), WNT1(1) 13136162 83 72 72 5 10 15 14 16 28 0 2.27e-05 5.88e-15 5.77e-14 62 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(3), AKT1(1), BCL2(2), CSF2RB(4), IGF1(2), IGF1R(3), IL3(1), IL3RA(2), KIT(3), KITLG(1), PIK3CA(33), PIK3R1(33), PRKAR1B(1), PRKAR2B(1), YWHAH(1) 9316577 91 78 79 6 15 14 13 19 30 0 1.23e-05 6.00e-15 5.77e-14 63 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EGF(3), EGFR(92) 5453974 95 77 47 11 10 44 2 35 4 0 3.02e-05 6.00e-15 5.77e-14 64 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), NTRK1(1), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), SOS1(3) 6613121 78 70 67 3 7 13 13 17 28 0 6.03e-06 6.00e-15 5.77e-14 65 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), CASP9(1), CHUK(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(1), PIK3CA(33), PIK3R1(33), RAF1(1), RALBP1(1), RALGDS(3) 8174511 79 69 68 1 8 13 14 16 28 0 8.12e-08 6.11e-15 5.79e-14 66 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), ELK1(2), FOS(1), INSR(2), IRS1(4), MAP2K1(1), MAPK3(1), PIK3CA(33), PIK3R1(33), PTPN11(4), RAF1(1), SOS1(3), SRF(1) 10842244 87 76 76 6 9 15 14 19 30 0 5.12e-05 6.22e-15 5.80e-14 67 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(4), ATR(4), BRCA1(4), CDKN1A(1), CHEK1(3), EP300(1), MDM2(2), PRKDC(3), RPS6KA1(1), TP53(96), WEE1(1), YWHAH(1) 18037415 121 95 84 8 35 22 15 27 22 0 7.88e-09 6.33e-15 5.82e-14 68 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(1), CALM1(1), EGFR(92), ELK1(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), MEF2A(2), MEF2D(1), PAK1(1), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2), SYT1(1) 14306176 122 95 72 11 17 53 7 37 8 0 8.06e-09 6.77e-15 6.13e-14 69 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BTK(1), CAD(3), CASP10(1), CASP8AP2(1), CD7(2), DAXX(3), DEDD(1), DEDD2(1), EGFR(92), EPHB2(3), FAF1(1), IL1A(1), MAP3K1(6), MAP3K5(1), MAPK1(2), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3), MET(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NR0B2(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(2), TP53(96), TPX2(2) 31290080 237 161 150 24 53 72 25 62 25 0 8.48e-14 7.11e-15 6.34e-14 70 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(2), CAPNS1(1), EGF(3), EGFR(92), ITGA1(2), ITGB1(1), MAPK1(2), MAPK3(1), MYLK(2), PRKAR1B(1), PRKAR2B(1), PXN(1) 13968549 109 86 61 13 15 45 4 40 5 0 1.53e-06 7.88e-15 6.94e-14 71 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(3), EGFR(92), ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(6), MAPK3(1), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1) 15926774 190 136 129 16 20 63 17 55 35 0 1.48e-10 8.22e-15 7.12e-14 72 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CDKN1B(1), CUL1(3), RB1(24), SKP2(1), TFDP1(1), UBE2M(1) 3656184 32 30 30 2 0 1 1 5 24 1 0.0126 8.33e-15 7.12e-14 73 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(4), CCNA1(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), CREB3L1(1), CREB3L3(3), CREB3L4(1), E2F4(1), E2F6(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), NACA(1), POLA2(1), POLE2(1), PRIM1(1), RB1(24), RBL1(2), RPA2(1), TFDP1(1), TNXB(3), TP53(96), WEE1(1) 32840958 173 120 134 11 36 23 19 41 53 1 4.94e-12 8.55e-15 7.21e-14 74 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(6), MAPK3(1), PDGFRA(14), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1) 14833818 109 92 95 6 10 24 18 24 33 0 2.10e-07 8.77e-15 7.30e-14 75 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), FOS(1), JAK2(1), MAP2K1(1), MAPK3(1), MPL(3), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), STAT1(2), STAT3(1), THPO(1) 12700557 89 80 78 3 11 14 14 20 30 0 5.88e-07 9.21e-15 7.57e-14 76 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYB(1), RB1(24), SP1(1), SP3(1) 2820064 27 26 25 2 0 1 1 2 22 1 0.0550 3.01e-14 2.44e-13 77 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CCNE1(1), CUL1(3), RB1(24), SKP2(1), TFDP1(1) 3652936 31 30 29 2 0 1 0 6 23 1 0.0202 3.66e-14 2.93e-13 78 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), BCL2(2), GSK3B(1), IL4R(7), IRS1(4), JAK1(2), JAK3(2), MAP4K1(2), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), RAF1(1), SOCS1(1), SOS1(3), STAT6(1) 15610014 96 83 85 9 14 14 15 21 32 0 0.000221 7.29e-14 5.76e-13 79 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CUL1(3), FBXW7(1), RB1(24), TFDP1(1) 3534563 30 29 28 2 0 1 0 4 24 1 0.0244 1.14e-13 8.91e-13 80 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(3), FYN(1), GSN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), MYLK(2), PIK3CA(33), PIK3R1(33), PXN(1), RAF1(1), ROCK1(2), SRC(2) 15888902 86 74 74 5 9 13 14 20 30 0 2.92e-05 1.66e-13 1.28e-12 81 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), BCL2(2), CBL(1), CRKL(1), FOS(1), IRS1(4), JAK1(2), JAK3(2), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), PTPN6(1), RAF1(1), SOCS1(1), SOS1(3) 15417577 89 78 78 8 11 13 15 19 31 0 0.000511 3.07e-13 2.34e-12 82 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND2(2), CCND3(1), CCNE1(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), RB1(24), RBL1(2), TFDP1(1) 6752337 42 40 40 3 0 2 1 9 29 1 0.0111 9.96e-13 7.48e-12 83 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(3), EGFR(92), MAP2K1(1), MAPK1(2), MAPK3(1), PTPRB(3), RAF1(1), SOS1(3), SPRY3(2), SRC(2) 10614760 111 91 63 18 13 46 5 41 6 0 0.000282 1.13e-12 8.36e-12 84 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAPK1(2), MAPK13(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PIK3CA(33), PIK3R1(33), SYT1(1) 14325300 82 72 71 7 10 14 15 15 28 0 0.000273 4.10e-12 3.01e-11 85 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(2), CHUK(1), DAXX(3), EGF(3), EGFR(92), ETS1(2), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K5(1), MAPK1(2), MAPK13(1), MAPK3(1), NFKB1(1), NFKBIA(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), RAF1(1), RIPK1(1), SP1(1), TNFRSF1A(1), TNFRSF1B(1) 20924107 136 106 85 19 22 53 9 41 11 0 9.40e-07 9.49e-12 6.88e-11 86 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(5), CALM1(1), CAMK1(1), IGF1(2), IGF1R(3), INSR(2), MAPK7(1), MEF2A(2), MEF2D(1), MYOD1(1), NFATC2(2), PIK3CA(33), PIK3R1(33), PPP3CB(1), SYT1(1), YWHAH(1) 14839504 91 81 80 10 11 15 16 19 30 0 0.000336 7.56e-11 5.42e-10 87 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CD36(1), CREBBP(4), EHHADH(1), EP300(1), FABP1(1), HSD17B4(1), MAPK1(2), MAPK3(1), ME1(1), NCOA1(1), NCOR1(1), NCOR2(2), NFKBIA(1), NR0B2(1), NRIP1(2), PIK3CA(33), PIK3R1(33), PPARA(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PTGS2(1), RB1(24), RXRA(3), SP1(1) 26943595 120 104 107 10 14 17 13 20 55 1 2.90e-06 8.44e-11 5.97e-10 88 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 AKT1(1), ANGPTL2(1), DAG1(2), DGKA(1), GCA(1), ITGA9(2), ITPR1(5), ITPR2(3), ITPR3(5), MAP2K1(1), MAPK1(2), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(3), PDE3B(3), PIK3C2G(9), PIK3CA(33), PIK3R1(33), RIPK3(1), RPS4X(1), VASP(1) 20859776 111 96 100 11 21 23 17 17 33 0 3.82e-06 2.11e-10 1.48e-09 89 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 BCL2(2), BIRC2(1), BIRC3(1), CASP1(4), CASP10(1), CASP9(1), CHUK(1), GZMB(2), IKBKB(1), IRF1(1), IRF2(1), IRF4(2), IRF5(1), IRF6(2), MAP3K1(6), MDM2(2), NFKB1(1), NFKBIA(1), NFKBIE(2), PLEKHG5(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF25(1), TNFSF10(2), TP53(96), TRAF1(1) 24488753 137 107 98 14 40 25 15 32 25 0 2.56e-08 3.60e-10 2.49e-09 90 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), ASAH1(1), BRAF(6), DAG1(2), DRD2(1), EGFR(92), EPHB2(3), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PIK3CB(4), PITX2(3), PLCB1(1), PLCB2(3), PLCB4(1), RAF1(1), SOS1(3), SRC(2), STAT3(1) 25021358 143 102 91 16 24 59 8 44 8 0 2.56e-09 5.79e-10 3.96e-09 91 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), CALM1(1), ELK1(2), FCER1A(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), NFATC2(2), NFATC4(2), PIK3CA(33), PIK3R1(33), PLA2G4A(3), PLCG1(6), PPP3CB(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4) 18292304 108 88 95 12 13 23 19 22 31 0 5.40e-05 1.71e-09 1.16e-08 92 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), DLD(2), DUSP10(1), IL1R1(2), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPK7(1), NR2C2(1), PAPPA(2), TP53(96) 21460109 124 97 85 13 35 26 16 28 19 0 3.72e-07 2.55e-09 1.71e-08 93 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(6), GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), GABRA6(11), GPX1(1), PRKCE(1) 3351823 29 29 28 4 8 5 5 9 2 0 0.0229 5.31e-09 3.52e-08 94 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CD3E(2), CD3G(1), ELK1(2), FOS(1), FYN(1), MAP2K1(1), MAP3K1(6), MAPK3(1), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PIK3CA(33), PIK3R1(33), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4), ZAP70(3) 20335778 108 89 95 11 17 18 19 22 32 0 3.04e-05 1.28e-08 8.38e-08 95 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), ASAH1(1), BRAF(6), CREB1(1), CREBBP(4), CRKL(1), DAG1(2), EGR1(3), EGR2(2), EGR3(1), ELK1(2), MAP1B(2), MAPK1(2), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3), NTRK1(1), PIK3C2G(9), PIK3CA(33), PIK3R1(33), PTPN11(4), RPS6KA3(1), SRC(2) 22042016 118 96 103 15 17 20 20 27 34 0 0.000196 3.13e-08 2.03e-07 96 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), CDKN1A(1), ELK1(2), MAP2K1(1), NTRK1(1), PIK3CA(33), SOS1(3) 6966902 42 38 37 4 6 11 8 8 9 0 0.00202 3.79e-08 2.43e-07 97 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(6), EGFR(92), ERBB2(1), ETS1(2), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NOTCH2(5), NOTCH3(1), NOTCH4(2), PIWIL1(2), PIWIL2(2), PIWIL3(2), PIWIL4(1), RAF1(1), SOS1(3), SPIRE1(1), SPIRE2(1) 22362047 128 101 75 17 18 52 8 42 8 0 2.95e-06 3.90e-08 2.48e-07 98 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(1), AKT1(1), CALM1(1), CAMK1(1), CAMK4(1), CREBBP(4), ELSPBP1(3), F2(1), GATA4(2), GSK3B(1), IGF1(2), MAP2K1(1), MAPK1(2), MAPK3(1), MYH2(9), NFATC2(2), NFATC4(2), NPPA(2), PIK3CA(33), PIK3R1(33), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), RAF1(1), SYT1(1) 21576496 108 87 97 12 19 15 16 24 34 0 9.92e-05 1.79e-07 1.13e-06 99 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), BRAF(6), EIF4B(1), FIGF(2), IGF1(2), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), RICTOR(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), TSC2(3), ULK1(1), ULK2(2), VEGFA(2), VEGFB(1), VEGFC(1) 22787556 117 97 102 13 20 22 16 29 30 0 6.67e-05 8.74e-07 5.44e-06 100 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), IARS(3), IL4R(7), INPP5D(3), JAK1(2), JAK2(1), JAK3(2), NR0B2(1), PIK3CA(33), SOS1(3), SRC(2), STAT6(1), TYK2(3) 15751487 62 56 57 5 17 13 8 15 9 0 0.000105 2.05e-05 0.000126 101 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(2), ACTN1(2), AKT1(1), ANGPTL2(1), ARHGEF6(2), ARHGEF7(2), BRAF(6), CDKN2A(2), CSE1L(1), DOCK1(2), EPHB2(3), FYN(1), GRB7(2), ITGA1(2), ITGA10(1), ITGA11(1), ITGA2(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), MAPK1(2), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3), MYLK(2), P4HB(1), PAK1(1), PAK4(2), PAK7(1), PIK3CA(33), PIK3CB(4), PKLR(1), PLCG1(6), PLCG2(3), PTEN(90), RAF1(1), ROCK1(2), ROCK2(1), SOS1(3), SRC(2), TLN2(2), VASP(1), WAS(1), ZYX(2) 52135155 209 153 183 29 32 42 29 44 62 0 3.65e-07 5.74e-05 0.000350 102 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), IDH1(14), SUCLA2(1) 3766493 16 16 4 0 13 1 0 2 0 0 0.00247 0.000196 0.00118 103 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IFNG(2), IL12B(2) 1269839 8 8 8 1 2 2 1 1 2 0 0.218 0.000315 0.00188 104 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GPX5(1), GSS(1), GSTA1(2), GSTA4(2), IDH1(14) 7695328 26 26 14 0 17 3 1 4 1 0 8.73e-05 0.000452 0.00268 105 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(2), ATM(4), BUB1(1), CCNA1(1), CCNA2(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(2), CDKN1A(1), CDKN2A(2), CHEK1(3), DTX4(2), E2F4(1), E2F6(1), EP300(1), ESPL1(3), GSK3B(1), HDAC2(3), HDAC4(1), HDAC6(1), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), MPEG1(1), MPL(3), PRKDC(3), PTPRA(3), RB1(24), RBL1(2), SKP2(1), SMAD4(1), TBC1D8(3), TFDP1(1), TP53(96), WEE1(1) 47118372 192 131 153 22 46 30 16 47 52 1 1.94e-08 0.000613 0.00360 106 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GPX5(1), GSS(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(1), IDH1(14), OPLAH(1) 9353153 29 29 17 0 19 4 1 4 1 0 2.19e-05 0.00147 0.00852 107 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(2), ANAPC1(1), ANAPC4(2), ANAPC7(1), ATM(4), ATR(4), BUB1(1), CCNA1(1), CCNA2(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDC23(2), CDC27(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), CHEK1(3), CREBBP(4), CUL1(3), DBF4(1), EP300(1), ESPL1(3), FZR1(1), GADD45B(1), GSK3B(1), HDAC2(3), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), PRKDC(3), RB1(24), RBL1(2), SFN(1), SKP2(1), SMAD4(1), SMC1A(6), SMC1B(2), TFDP1(1), TP53(96), WEE1(1), YWHAE(2), YWHAH(1) 58157729 214 139 175 25 38 36 21 56 62 1 1.80e-08 0.00202 0.0116 108 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(3), LYN(2), MAP2K1(1), MAPK1(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PIK3CA(33), PIK3R1(33), PLCG2(3), RAF1(1), SOS1(3), VAV1(4) 22425272 96 81 85 13 10 21 17 19 29 0 0.00157 0.00294 0.0168 109 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(6), GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), GABRA6(11), SRC(2) 5082417 29 28 28 5 8 6 4 9 2 0 0.0552 0.00302 0.0171 110 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(2), ABL2(2), AKT1(1), AREG(1), BRAF(6), CAMK2A(1), CBL(1), CBLB(1), CDKN1A(1), CDKN1B(1), CRKL(1), EGF(3), EGFR(92), ELK1(2), ERBB2(1), GSK3B(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), NRG1(2), NRG4(1), PAK1(1), PAK4(2), PAK7(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PRKCA(1), PRKCG(2), RAF1(1), SHC4(1), SOS1(3), SRC(2), TGFA(4) 43998258 238 157 174 33 36 70 23 72 37 0 1.75e-08 0.00326 0.0182 111 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), CASP9(1), KDR(8), KRAS(2), MAP2K1(1), MAPK1(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFATC2(2), NFATC4(2), NOS3(3), NRAS(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCG1(6), PLCG2(3), PPP3CB(1), PRKCA(1), PRKCG(2), PTGS2(1), PXN(1), RAF1(1), SRC(2), VEGFA(2) 30858023 137 109 125 20 28 28 15 31 35 0 3.85e-05 0.00377 0.0209 112 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), CHUK(1), CSK(1), CXCL1(1), EGFR(92), F11R(1), IKBKB(1), LYN(2), MAPK13(1), MET(3), NFKB1(1), NFKB2(1), NFKBIA(1), NOD1(2), PAK1(1), PLCG1(6), PLCG2(3), PTPN11(4), PTPRZ1(3), SRC(2), TJP1(3) 29861084 144 106 96 24 22 55 8 48 11 0 1.42e-05 0.00516 0.0284 113 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD3E(2), CD3G(1), CD4(1), CD58(1), CD8A(1), IL3(1), IL6(1), KITLG(1) 2644975 10 10 10 1 3 1 1 3 2 0 0.152 0.00551 0.0300 114 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(5), AGT(1), AGTR1(1), AGTR2(1), KNG1(2), NOS3(3), REN(5) 4284311 18 18 17 2 10 2 0 2 4 0 0.0401 0.00749 0.0404 115 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(1), ACO1(1), IDH1(14), SUCLA2(1) 5627784 17 17 5 0 13 1 0 2 1 0 0.00175 0.00754 0.0404 116 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(1), CD3E(2), CD3G(1), CD4(1) 1364210 6 6 6 1 3 0 1 1 1 0 0.360 0.0130 0.0689 117 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(3) 306178 3 3 3 0 2 1 0 0 0 0 0.300 0.0139 0.0733 118 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(1) 483380 3 3 3 0 0 0 1 1 1 0 0.420 0.0152 0.0793 119 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(1), IFNGR2(3), JAK1(2), JAK2(1), STAT1(2) 3472100 11 11 11 0 0 0 3 5 3 0 0.0666 0.0154 0.0797 120 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(3), NR0B2(1), NR1H4(3), RXRA(3) 2319597 11 11 11 2 4 2 0 4 1 0 0.239 0.0159 0.0814 121 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(1), LUM(5) 1535551 6 6 5 1 3 0 0 2 1 0 0.398 0.0228 0.116 122 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), CSF2(2), HLA-DRA(1), IL3(1) 1289447 5 5 5 0 2 1 1 0 1 0 0.202 0.0255 0.129 123 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), DLD(2), IDH1(14), IDH3A(1), PC(2), PCK1(3), SUCLA2(1), SUCLG1(2) 8730119 26 25 14 3 15 4 0 7 0 0 0.0121 0.0264 0.132 124 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(2), GALT(1), TGDS(1), UXS1(2) 1665957 6 6 6 0 1 1 1 2 1 0 0.142 0.0276 0.137 125 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(5), ACE2(2), AGT(1), AGTR1(1), AGTR2(1), ANPEP(2), CMA1(1), CTSG(3), ENPEP(4), LNPEP(2), MME(1), REN(5) 9005394 28 27 27 4 12 4 1 5 6 0 0.0265 0.0332 0.164 126 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(1), DAXX(3), FAF1(1), LMNB2(1), MAP3K1(6), MAP3K7(3), PAK1(1), PRKDC(3), PTPN13(1), RB1(24), SPTAN1(3) 17695192 47 44 43 5 3 9 4 4 26 1 0.00476 0.0339 0.166 127 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), BTK(1), CSF2(2), FCER1A(2), FYN(1), GAB2(1), IL3(1), INPP5D(3), KRAS(2), LYN(2), MAP2K1(1), MAP2K3(3), MAPK1(2), MAPK13(1), MAPK3(1), NRAS(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCG1(6), PLCG2(3), PRKCA(1), PRKCD(3), PRKCE(1), RAF1(1), SOS1(3), VAV1(4), VAV2(2), VAV3(1) 30774389 140 109 127 24 29 26 21 29 35 0 0.00106 0.0464 0.225 128 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF2(2), EPO(1), FLT3(4), IGF1(2), IL1A(1), IL3(1), IL6(1), KITLG(1) 3536223 14 14 14 3 2 3 2 5 2 0 0.268 0.0538 0.259 129 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD2(1), CD33(5), CD5(2), CD7(2), CSF2(2), IFNB1(1), IFNG(2), IL12B(2), IL3(1), ITGAX(6), TLR2(4), TLR7(4), TLR9(2) 7877452 36 34 36 8 16 3 3 10 4 0 0.0885 0.0598 0.286 130 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(2), GALT(1), TGDS(1), UXS1(2) 2109382 6 6 6 0 1 1 1 2 1 0 0.143 0.0653 0.309 131 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR161(2), GPR34(2), GPR45(3), GPR65(2), GPR68(1), GPR75(1) 4176509 12 11 12 2 4 1 2 2 3 0 0.155 0.0691 0.325 132 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDK7(1), CDKN1A(1), CHEK1(3), NEK1(2), WEE1(1) 3005083 8 8 8 0 1 2 0 4 1 0 0.183 0.0886 0.414 133 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(2), HLA-DRA(1), IFNG(2), IFNGR1(1), IFNGR2(3), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(7) 5392786 25 22 25 5 13 0 3 6 3 0 0.0767 0.0894 0.414 134 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(1), CSF2(2), EPO(1), IL3(1), IL6(1), IL7(1) 2604628 8 8 8 2 3 2 1 1 1 0 0.347 0.0929 0.427 135 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CRADD(1), LMNB2(1), MADD(1), MAP3K1(6), MAP3K7(3), PAK1(1), PRKDC(3), RB1(24), RIPK1(1), SPTAN1(3), TNFRSF1A(1) 16753284 45 41 41 6 4 7 3 5 25 1 0.0139 0.0965 0.440 136 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT2(1), TAT(2), TYR(1) 1990084 7 6 6 0 4 1 2 0 0 0 0.0774 0.107 0.485 137 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), PPARG(1), RETN(1), RXRA(3) 2459401 7 7 7 0 3 1 0 1 2 0 0.110 0.115 0.518 138 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(1), JAK3(2), MAPK1(2), MAPK3(1), STAT3(1), TYK2(3) 5038232 12 12 12 1 6 2 1 2 1 0 0.0925 0.144 0.641 139 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), IFNB1(1), JAK1(2), STAT1(2), STAT2(1), TYK2(3) 4602823 10 10 10 1 3 1 1 3 2 0 0.157 0.145 0.641 140 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), PTK2B(3), SOS1(3), SRC(2) 3752639 9 9 9 1 2 1 1 3 2 0 0.249 0.154 0.679 141 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADS(3), ECHS1(1), HADHA(1) 2299164 5 5 5 1 2 2 1 0 0 0 0.358 0.163 0.714 142 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNA2(1), CCNE1(1), CCNE2(1), CDKN1B(1), CDKN2A(2), E2F4(1), PRB1(1) 3775834 9 9 9 1 1 0 1 5 2 0 0.298 0.166 0.714 143 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(1), CD3E(2), CD3G(1), CD4(1), IFNG(2), IL12B(2), IL12RB1(2), IL12RB2(2), JAK2(1), STAT4(2), TYK2(3) 6293559 20 18 20 4 12 0 3 2 3 0 0.156 0.167 0.714 144 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(1), CES1(2) 2567248 7 7 7 1 6 1 0 0 0 0 0.198 0.168 0.714 145 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BRAF(6), CREB1(1), MAPK1(2), RAF1(1), SRC(2) 4820294 13 11 9 2 1 3 2 6 1 0 0.284 0.168 0.714 146 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(4), PSAT1(2) 2053439 6 5 5 1 4 2 0 0 0 0 0.225 0.188 0.794 147 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), IL4R(7), JAK1(2), JAK2(1), TYK2(3) 4447774 14 14 14 3 6 1 0 5 2 0 0.303 0.194 0.808 148 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), IL4R(7), JAK1(2), JAK2(1), TYK2(3) 4447774 14 14 14 3 6 1 0 5 2 0 0.303 0.194 0.808 149 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), BCL2(2), BTK(1), CD19(1), CD22(6), CR2(4), CSK(1), DAG1(2), FLOT1(1), GSK3B(1), INPP5D(3), ITPR1(5), ITPR2(3), ITPR3(5), LYN(2), MAP4K1(2), MAPK1(2), MAPK3(1), NFATC2(2), NR0B2(1), PIK3CA(33), PIK3R1(33), PLCG2(3), PPP3CB(1), PTPRC(2), RAF1(1), SOS1(3), VAV1(4) 31593287 126 98 115 21 28 23 17 22 36 0 0.000761 0.208 0.861 150 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), CSNK2A1(1), ELK1(2), FOS(1), IL6(1), JAK1(2), JAK2(1), JAK3(2), MAP2K1(1), MAPK3(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1), STAT3(1) 10215016 23 22 23 2 5 4 2 9 3 0 0.0368 0.212 0.871 151 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(1), HLA-DRA(1) 1012861 3 3 3 0 3 0 0 0 0 0 0.329 0.228 0.930 152 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(2), CD3G(1), IFNG(2), TGFBR1(2), TGFBR2(2), TGFBR3(1) 4512797 11 11 11 2 1 3 3 2 2 0 0.183 0.241 0.976 153 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(2), CA12(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLUL(1), HAL(2) 8058632 16 15 16 1 6 3 2 3 2 0 0.0287 0.246 0.992 154 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(3), MAP2K1(1), MAPK1(2), MAPK3(1), RAF1(1) 3525953 8 8 8 0 2 1 2 1 2 0 0.116 0.250 0.999 155 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(1), TAT(2) 1112386 3 3 2 0 2 1 0 0 0 0 0.315 0.271 1.000 156 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(1), EHHADH(1), HADHA(1) 2057108 4 4 4 1 0 3 0 0 1 0 0.424 0.278 1.000 157 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 CALM1(1), CRKL(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), PAK1(1), PLCG1(6), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2), SYT1(1) 12123333 33 29 31 5 9 7 6 5 6 0 0.0211 0.286 1.000 158 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(2), CALM1(1), CAMK2A(1), CLCA1(2), CLCA2(1), CLCA4(1), CNGA4(3), CNGB1(2), GUCA1C(1), PDC(1), PDE1C(4), PRKG1(1), PRKG2(5), PRKX(1) 12965576 29 28 29 3 13 6 4 3 3 0 0.00627 0.292 1.000 159 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC1(3), APOBEC2(1), APOBEC3B(1), APOBEC3F(3) 3098761 8 8 8 2 4 1 2 1 0 0 0.420 0.305 1.000 160 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(1) 770612 2 2 2 0 1 1 0 0 0 0 0.440 0.341 1.000 161 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(1), F5(6), FGA(6), FGB(3), FGG(5), PROS1(2), SERPINC1(1) 6944066 25 25 25 6 6 6 4 6 3 0 0.158 0.342 1.000 162 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2RL3(2), GNB1(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PLA2G4A(3), PLCB1(1), PRKCA(1), PTGS1(1), RAF1(1), SRC(2), TBXAS1(1) 10363627 21 19 21 1 8 3 2 6 2 0 0.0116 0.352 1.000 163 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CREB1(1), DAXX(3), DDIT3(1), ELK1(2), MAP3K1(6), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPKAPK2(1), MAX(2), MEF2A(2), MEF2D(1), PLA2G4A(3), RIPK1(1), RPS6KA5(1), STAT1(2), TGFBR1(2) 15632928 35 32 33 4 7 12 5 8 3 0 0.00463 0.352 1.000 164 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(1), GOT2(1), PAH(2), TAT(2) 3509035 7 7 6 1 4 1 0 2 0 0 0.329 0.361 1.000 165 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(5), CD44(3), IL1B(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1) 5711760 14 14 14 3 4 1 1 3 5 0 0.214 0.368 1.000 166 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(4), CCND2(2), CDKN1B(1), CEBPB(1), EGR1(3), ESR2(3), FSHR(1), LHCGR(2), MSH5(2), NCOR1(1), NRIP1(2), PGR(5), ZP2(2) 14906594 29 28 29 3 4 8 3 10 4 0 0.0289 0.370 1.000 167 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNG(2), IFNGR1(1), JAK1(2), JAK2(1), PTPRU(1), STAT1(2) 4872602 9 9 9 1 1 0 1 4 3 0 0.308 0.376 1.000 168 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), CBS(1), CTH(1), MUT(1) 2084149 4 4 4 1 1 0 1 2 0 0 0.612 0.401 1.000 169 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(6), PRKCA(1), PTK2B(3) 2855115 11 10 11 3 5 1 1 2 2 0 0.350 0.404 1.000 170 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), IL6(1), LDLR(3) 2259343 5 5 5 2 0 1 0 4 0 0 0.776 0.407 1.000 171 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), HDAC9(2), MEF2A(2), MEF2D(1), MYOD1(1), YWHAH(1) 3378974 8 8 8 2 1 3 1 2 1 0 0.382 0.414 1.000 172 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(2) 1367854 2 2 2 0 1 0 1 0 0 0 0.486 0.420 1.000 173 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), NR1I3(1), PTGS1(1), PTGS2(1) 2252596 6 6 6 2 1 2 0 1 2 0 0.499 0.429 1.000 174 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH1C(2) 2384291 6 5 6 2 2 0 0 4 0 0 0.641 0.433 1.000 175 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(2) 1647182 3 3 3 1 2 1 0 0 0 0 0.573 0.436 1.000 176 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(2), IDI2(1) 1823615 3 3 3 0 1 0 1 1 0 0 0.407 0.448 1.000 177 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(1), CALM1(1), CHRM1(1), FLT1(5), FLT4(2), KDR(8), NOS3(3), PDE2A(1), PDE3A(3), PDE3B(3), PRKAR1B(1), PRKAR2B(1), PRKG1(1), PRKG2(5), RYR2(30), SLC7A1(1), SYT1(1) 17458784 68 61 68 15 30 13 9 11 5 0 0.00634 0.471 1.000 178 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), CD4(1), HLA-DRA(1), IL1B(1), IL5RA(1), IL6(1) 2266494 6 6 6 2 4 0 0 1 1 0 0.591 0.473 1.000 179 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(2), CA12(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLUD2(3), GLUL(1), HAL(2) 9019043 19 17 19 2 8 3 2 4 2 0 0.0410 0.474 1.000 180 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 697988 1 1 1 0 0 0 1 0 0 0 0.685 0.475 1.000 181 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP54(2), SRPR(2) 3185647 5 5 5 0 1 1 1 1 1 0 0.228 0.487 1.000 182 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(4), CHEK1(3), WEE1(1), YWHAH(1) 5850893 9 9 9 0 1 0 3 3 2 0 0.135 0.490 1.000 183 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CSK(1), PRKCA(1), PTPRA(3), SRC(2) 3911924 7 7 7 0 3 3 0 1 0 0 0.0572 0.512 1.000 184 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1), SIRT2(1), SIRT5(1), VNN2(1) 5046088 8 8 8 0 2 3 0 1 2 0 0.0653 0.544 1.000 185 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CD28(1), CD4(1), CSF2(2), IFNG(2), IFNGR1(1), IFNGR2(3), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(7) 8541406 30 26 30 8 14 0 4 7 5 0 0.183 0.554 1.000 186 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2) 1636291 2 2 2 0 0 0 0 0 2 0 1.000 0.560 1.000 187 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(1), CPO(1), FECH(1), GATA1(1), HMBS(1) 3386319 5 5 5 1 0 1 1 3 0 0 0.496 0.565 1.000 188 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), MPO(2), TPO(4), TYR(1) 4122534 9 9 9 2 6 0 1 1 1 0 0.344 0.604 1.000 189 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), CNDP1(2), DDC(3), HAL(2), HARS(2), HDC(3), MAOA(1), MAOB(2), PRPS2(2) 10394313 29 24 29 4 18 3 1 7 0 0 0.0123 0.607 1.000 190 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA2C(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), DRD1(1), DRD2(1), DRD3(1), DRD5(7), HRH2(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3) 10888266 38 36 38 9 26 5 2 5 0 0 0.00835 0.612 1.000 191 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(1) 1654777 2 2 2 1 0 0 1 1 0 0 0.841 0.615 1.000 192 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 SUCLA2(1) 893936 1 1 1 0 0 1 0 0 0 0 0.642 0.620 1.000 193 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(3), PRKCA(1), TGM2(1) 2132325 5 5 5 2 2 0 0 3 0 0 0.689 0.632 1.000 194 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(2), HS3ST3A1(2), XYLT1(1), XYLT2(2) 2833757 7 7 7 2 4 0 3 0 0 0 0.510 0.635 1.000 195 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(2), HS3ST3A1(2), XYLT1(1), XYLT2(2) 2833757 7 7 7 2 4 0 3 0 0 0 0.510 0.635 1.000 196 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(2), PTPRU(1), STAT1(2), STAT2(1), TYK2(3) 5325678 10 10 10 2 4 0 1 3 2 0 0.352 0.641 1.000 197 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 BCL2(2), CASP8AP2(1), CASP9(1), CES1(2) 4767392 6 6 6 1 2 1 0 1 2 0 0.563 0.648 1.000 198 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BCL2(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), NFKB1(1), NSMAF(2), RAF1(1), RIPK1(1), TNFRSF1A(1) 8752248 18 17 16 4 5 5 3 1 4 0 0.193 0.649 1.000 199 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4), GZMB(2) 4506411 6 6 6 1 0 1 2 0 3 0 0.355 0.657 1.000 200 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), MIOX(1), OCRL(2), PIK3C2A(1), PIK3C2B(1), PIK3C2G(9), PIK3CA(33), PIK3CB(4), PIK3CG(7), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCG1(6), PLCG2(3) 19144115 81 70 76 17 21 14 12 19 15 0 0.0334 0.672 1.000 201 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(1), FECH(1), HMBS(1), PPOX(1) 3232721 4 4 4 0 0 1 1 1 1 0 0.296 0.677 1.000 202 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(4), LCT(3), MAN2B1(5), MAN2B2(2), NEU1(1), NEU2(3), NEU4(2) 8714792 20 18 20 4 6 4 1 7 2 0 0.118 0.678 1.000 203 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), CHST13(1), CHSY1(2), DSE(3), UST(1), XYLT1(1), XYLT2(2) 5973536 11 11 11 1 4 2 1 2 2 0 0.0507 0.681 1.000 204 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(1), ME1(1), PC(2), PDHA1(1), SLC25A11(1) 3930491 6 6 6 1 1 1 0 3 1 0 0.464 0.688 1.000 205 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CTH(1), GOT2(1), LDHAL6A(1), LDHAL6B(1), SULT1B1(7) 5313633 11 10 11 3 0 3 1 6 1 0 0.543 0.689 1.000 206 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(1), CD4(1), FYN(1), HLA-DRA(1), PTPRC(2), ZAP70(3) 3839630 11 11 11 4 6 0 2 2 1 0 0.591 0.691 1.000 207 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1) 3502193 4 4 4 1 2 0 0 1 1 0 0.687 0.700 1.000 208 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD2(3) 1919184 4 4 4 2 2 0 0 2 0 0 0.828 0.705 1.000 209 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), GNB1(1), HTR2C(1), PLCB1(1) 3037326 4 4 4 1 1 1 0 1 1 0 0.668 0.711 1.000 210 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(2), EPO(1), FOS(1), JAK2(1), MAP2K1(1), MAPK3(1), PLCG1(6), PTPN6(1), RAF1(1), SOS1(3) 9160787 19 18 19 4 5 2 3 6 3 0 0.247 0.713 1.000 211 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(1), HADHA(1), HSD17B4(1), MECR(1) 3613794 4 4 4 0 0 2 0 1 1 0 0.300 0.715 1.000 212 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(3), F2(1), FGA(6), FGB(3), FGG(5), PLAT(2), PLG(2), SERPINB2(1), SERPINE1(2) 5678902 25 24 25 8 7 6 4 7 1 0 0.348 0.715 1.000 213 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2) 3400299 6 6 6 2 4 1 0 1 0 0 0.458 0.716 1.000 214 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2) 3400299 6 6 6 2 4 1 0 1 0 0 0.458 0.716 1.000 215 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ECHS1(1), EHHADH(1), HADHA(1) 3540890 4 4 4 1 0 3 0 0 1 0 0.479 0.716 1.000 216 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), GOT2(1), PAH(2), TAT(2), YARS2(1) 3698863 7 7 6 2 3 2 0 2 0 0 0.506 0.725 1.000 217 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(4), EP300(1), IKBKB(1), IL1B(1), MAP2K3(3), MAP3K7(3), NFKB1(1), NFKBIA(1), TGFBR1(2), TGFBR2(2), TLR2(4) 12618706 24 22 24 4 5 7 3 3 6 0 0.0524 0.744 1.000 218 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), B4GALT2(1), CHST1(1), CHST2(2), CHST4(1), CHST6(2), FUT8(1), ST3GAL1(1) 5313442 10 9 10 1 6 1 1 1 1 0 0.108 0.757 1.000 219 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), FOS(1), MAPK1(2), PRKCA(1) 3788490 5 5 5 1 1 1 1 1 1 0 0.504 0.760 1.000 220 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(2), CD3G(1), ETV5(1), IFNG(2), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), JAK2(1), STAT4(2), TYK2(3) 7963691 21 19 21 5 11 0 4 3 3 0 0.212 0.766 1.000 221 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1) 4325458 6 6 6 1 2 1 0 3 0 0 0.368 0.767 1.000 222 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT3(2), B4GALT2(1), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GCNT2(1), ST3GAL6(2), ST8SIA1(1) 6863020 16 16 16 4 7 2 1 4 2 0 0.332 0.769 1.000 223 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(2), CD3G(1), CD4(1), CREBBP(4), CSK(1), GNB1(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3) 9799844 21 21 21 4 9 3 2 4 3 0 0.134 0.772 1.000 224 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(2), CD3G(1), CD4(1), CREBBP(4), CSK(1), GNB1(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3) 9799844 21 21 21 4 9 3 2 4 3 0 0.134 0.772 1.000 225 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(1), ACO1(1), CLYBL(4), DLD(2), IDH1(14), IDH3A(1), OGDHL(3), PC(2), PCK1(3), SUCLA2(1), SUCLG1(2) 12639678 34 31 22 7 16 4 1 12 1 0 0.0809 0.775 1.000 226 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(2) 2600576 3 3 3 0 1 1 1 0 0 0 0.295 0.776 1.000 227 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDPS(2), MVD(1), MVK(1), NQO1(1) 4757480 6 6 6 0 2 0 2 1 1 0 0.195 0.776 1.000 228 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK2(2), HK3(2), PGM1(1), TGDS(1) 4345095 6 6 6 1 4 1 0 1 0 0 0.316 0.776 1.000 229 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK2(1), JAK3(2), PIAS1(1), PIAS3(1), PTPRU(1), SOAT1(3) 5914289 11 10 11 2 3 2 0 4 2 0 0.369 0.777 1.000 230 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), CCL3(1), CD86(2), CHUK(1), FOS(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IKBKB(1), IL12B(2), IL1B(1), IL6(1), IRAK1(2), IRF5(1), LBP(3), LY96(2), MAP2K1(1), MAP2K3(3), MAP3K7(3), MAPK1(2), MAPK13(1), MAPK3(1), NFKB1(1), NFKB2(1), NFKBIA(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), RIPK1(1), STAT1(2), TLR1(2), TLR2(4), TLR3(1), TLR5(2), TLR6(5), TLR7(4), TLR8(1), TLR9(2) 38166888 146 105 135 29 35 28 17 29 37 0 0.00192 0.778 1.000 231 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(5), GLS(1) 3298444 6 5 6 2 2 0 2 2 0 0 0.668 0.783 1.000 232 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(1), ST6GALNAC4(1), ST8SIA1(1) 2397366 3 3 3 1 1 0 0 1 1 0 0.690 0.784 1.000 233 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(2), MPO(2), MTHFR(1), TPO(4) 4952370 9 9 9 2 6 0 1 1 1 0 0.368 0.785 1.000 234 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(4), FOS(1), IL3(1), IL3RA(2), JAK2(1), MAP2K1(1), MAPK3(1), PTPN6(1), RAF1(1), SOS1(3) 7500377 16 16 15 4 7 1 2 4 2 0 0.386 0.788 1.000 235 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), GBA(1), MPO(2), TPO(4) 3579089 9 9 9 3 7 0 0 1 1 0 0.532 0.788 1.000 236 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(1), PSMA5(1), PSMB8(2) 3700473 4 4 4 0 1 2 1 0 0 0 0.207 0.798 1.000 237 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(5), ACACB(7), MCAT(1), OXSM(1) 6800035 14 14 14 3 7 2 1 3 1 0 0.230 0.799 1.000 238 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(3), PLCE1(2), PRKAR1B(1), PRKAR2B(1), RAP2B(2) 6286626 9 9 9 0 4 2 1 1 1 0 0.0370 0.800 1.000 239 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(1), BMP4(1), BMP5(4), BMP6(1), BTRC(1), CSNK1D(1), CSNK1G1(1), CSNK1G3(1), DHH(1), FBXW11(1), GLI1(4), GLI2(3), GLI3(1), GSK3B(1), HHIP(1), IHH(1), LRP2(15), PRKX(1), PTCH2(2), RAB23(1), SHH(2), SMO(1), SUFU(1), WNT1(1), WNT10A(2), WNT11(1), WNT2(5), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1) 25960464 62 57 62 9 29 8 6 10 9 0 0.00113 0.804 1.000 240 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), CYR61(1), IFNG(2), IFRD1(1), IL1A(1), IL1R1(2), WDR1(2) 4626691 11 11 11 7 0 3 1 2 5 0 0.955 0.805 1.000 241 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), MAP2K1(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1), RAF1(1) 6579926 10 10 10 2 3 1 2 2 2 0 0.365 0.806 1.000 242 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(2), EIF2S2(1), EIF2S3(2), GSK3B(1) 4910905 7 7 7 2 0 1 2 2 2 0 0.630 0.807 1.000 243 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), JAK1(2), JAK2(1), JAK3(2), PIAS3(1), PTPRU(1), SRC(2), STAT3(1) 6542749 11 11 11 2 3 3 0 4 1 0 0.288 0.812 1.000 244 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADS(3), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(1), HADHA(1) 7143160 11 10 11 2 4 2 2 1 2 0 0.194 0.817 1.000 245 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3E(2), CD3G(1), GZMB(2), ICAM1(1), ITGB2(4) 3707758 11 11 11 6 3 0 2 2 4 0 0.780 0.828 1.000 246 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1) 3601428 4 4 4 1 1 0 1 2 0 0 0.589 0.828 1.000 247 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD1(1), GGT1(1) 2452281 2 2 2 0 0 2 0 0 0 0 0.374 0.829 1.000 248 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(1), NCOA1(1), NCOA2(3), PPARG(1), RXRA(3) 7845719 13 13 13 3 3 2 1 2 5 0 0.374 0.830 1.000 249 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(1) 2719804 3 3 3 0 2 0 0 1 0 0 0.360 0.830 1.000 250 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNB1(1) 2811420 4 4 4 0 2 1 0 1 0 0 0.269 0.834 1.000 251 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPT(2), ENPP1(1), TYR(1) 4115504 4 4 4 0 2 0 1 1 0 0 0.301 0.839 1.000 252 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1) 1380439 1 1 1 0 0 1 0 0 0 0 0.565 0.839 1.000 253 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 BIRC2(1), BIRC3(1), CASP10(1), CASP9(1), GZMB(2), SCAP(1), SREBF1(1), SREBF2(1) 7811487 9 9 9 1 2 1 2 3 1 0 0.203 0.839 1.000 254 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT3(2), FUT5(3), FUT6(1) 2174439 7 7 7 3 4 0 0 3 0 0 0.653 0.839 1.000 255 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP6(2), ACPT(2), ENPP1(1), LHPP(1), MTMR1(2), TYR(1) 6378333 9 9 9 2 5 1 2 1 0 0 0.353 0.840 1.000 256 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 GLS(1), PRODH(1) 2362656 2 2 2 1 1 0 0 1 0 0 0.804 0.840 1.000 257 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 CKB(1), CKM(1), CKMT1B(2), CPS1(5), GAMT(1), GATM(2), NAGS(1), OTC(2) 7483232 15 15 15 4 4 2 4 5 0 0 0.420 0.841 1.000 258 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), GNB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PIK3C2G(9), PLCB1(1), PPP1R12B(1), PRKCA(1), RAF1(1), ROCK2(1) 10772393 20 20 20 4 7 3 5 2 3 0 0.185 0.843 1.000 259 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(1), ESR1(1), MAPK1(2), MAPK3(1), SRC(2) 6262097 11 11 11 3 1 4 2 2 2 0 0.382 0.847 1.000 260 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSS(1), NFKB1(1), XDH(3) 4251755 6 6 6 2 2 1 0 3 0 0 0.616 0.850 1.000 261 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(5), ACACB(7), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), HADHA(1), HIBCH(1), LDHAL6A(1), LDHAL6B(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG1(2) 16832110 30 28 30 4 11 7 2 8 2 0 0.0245 0.850 1.000 262 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ECHS1(1), EHHADH(1), HADHA(1) 5171704 9 9 9 3 4 3 0 1 1 0 0.359 0.852 1.000 263 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(4), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), DDC(3), EPX(2), GOT2(1), MAOA(1), MAOB(2), MPO(2), TAT(2), TPO(4) 9372075 26 24 25 5 17 2 1 5 1 0 0.0525 0.853 1.000 264 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), TAX1BP3(1), UBE2E3(1), UBE2M(1), UBE3A(1) 4472034 5 5 5 1 2 1 1 0 1 0 0.325 0.856 1.000 265 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), CASP1(4), GAPDH(1), INSR(2), ITCH(1), MAGI1(2), MAGI2(2), RERE(4), WWP2(1) 10203599 20 18 20 4 3 7 2 5 3 0 0.205 0.856 1.000 266 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F13B(1), F2(1), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), LPA(4), PLAT(2), PLG(2), SERPINB2(1), SERPINE1(2), VWF(7) 14978207 51 45 51 13 16 11 5 12 7 0 0.0646 0.857 1.000 267 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(1), GGT1(1) 2393367 2 2 2 1 1 1 0 0 0 0 0.721 0.862 1.000 268 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(1), NDUFA4(1), NDUFS2(1) 2972368 3 3 3 1 0 1 0 1 1 0 0.723 0.866 1.000 269 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 NDUFA12(1) 1725322 1 1 1 1 1 0 0 0 0 0 0.901 0.867 1.000 270 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(3), CYP11B2(2), HSD11B1(2) 2925973 9 9 9 4 5 3 0 0 1 0 0.545 0.870 1.000 271 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 BIRC2(1), BIRC3(1), CASP1(4), CASP10(1), CASP9(1), GZMB(2), LMNB2(1) 8227520 11 11 11 2 1 2 3 3 2 0 0.271 0.875 1.000 272 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(1), HLA-DRA(1) 1688651 3 3 3 2 3 0 0 0 0 0 0.800 0.876 1.000 273 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1) 1794349 1 1 1 0 0 1 0 0 0 0 0.585 0.877 1.000 274 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH3A1(2), MIOX(1) 3637048 4 4 4 1 3 0 0 1 0 0 0.499 0.877 1.000 275 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(10), ABCB11(2), ABCB4(6), ABCC1(1), ABCC3(1) 6091514 20 20 20 7 7 4 1 4 4 0 0.390 0.877 1.000 276 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(2), ATG5(1), IFNA10(2), IFNA21(1), IFNG(2), ULK1(1), ULK2(2) 8971557 11 10 11 2 1 2 2 2 4 0 0.264 0.879 1.000 277 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 BCL2(2), CASP9(1), DAXX(3), IL1A(1), MAPKAPK2(1), MAPKAPK3(1) 4824263 9 8 9 3 1 3 1 2 2 0 0.603 0.884 1.000 278 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(1), RANGAP1(2) 3565182 3 3 3 0 1 0 0 1 1 0 0.404 0.887 1.000 279 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT2(1) 2892853 2 2 2 0 0 1 0 1 0 0 0.539 0.887 1.000 280 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 GLI2(3), GLI3(1), GSK3B(1), PRKAR1B(1), PRKAR2B(1), SHH(2), SMO(1), SUFU(1) 7131126 11 10 11 2 4 1 1 3 2 0 0.306 0.890 1.000 281 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(2), CAPNS1(1), CSNK1D(1), GSK3B(1) 3999313 6 6 6 2 1 2 1 2 0 0 0.515 0.892 1.000 282 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2) 5654565 9 8 9 3 4 0 0 5 0 0 0.564 0.894 1.000 283 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), FOS(1), MAPK3(1), OPRK1(1), POLR2A(2), PRKAR1B(1), PRKAR2B(1) 5478131 8 8 8 2 3 1 0 2 2 0 0.506 0.894 1.000 284 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK2(2), HK3(2), PGM1(1), TGDS(1) 4971588 6 6 6 1 4 1 0 1 0 0 0.301 0.896 1.000 285 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(4), LCT(3), NEU1(1), NEU2(3), NEU4(2) 7075584 13 11 13 3 4 4 1 3 1 0 0.222 0.898 1.000 286 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(5), MAP2(1), PRKAR2B(1), PRKCE(1) 7707285 8 7 8 0 0 1 2 2 3 0 0.211 0.900 1.000 287 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(2), MPO(2), TPO(4) 5043095 8 8 8 2 6 0 0 1 1 0 0.404 0.901 1.000 288 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(2), ALPPL2(4) 2803539 7 6 7 3 5 1 1 0 0 0 0.468 0.901 1.000 289 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(1), KARS(2) 2000648 3 3 3 2 2 0 0 1 0 0 0.892 0.903 1.000 290 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX5(1), CYP1A2(2), CYP2C19(2), CYP2C8(2), CYP2E1(1), CYP3A4(2), CYP3A43(1), CYP3A7(5), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1) 10138955 23 22 23 5 9 3 2 8 1 0 0.182 0.905 1.000 291 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), FSHR(1) 4070908 4 4 4 0 2 2 0 0 0 0 0.225 0.905 1.000 292 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(1), MST1(2), MST1R(2) 2795973 6 6 6 3 1 0 1 2 2 0 0.871 0.906 1.000 293 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), PPP1R1B(1) 1624132 2 2 2 2 2 0 0 0 0 0 0.834 0.907 1.000 294 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), CFTR(2), PRKAR1B(1), PRKAR2B(1) 5583723 7 7 7 0 4 1 0 2 0 0 0.104 0.908 1.000 295 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABP1(4), ALDH1A3(1), ALDH3A1(2), AOC2(1), CNDP1(2), DPYD(2), DPYS(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), HIBCH(1), MLYCD(1) 11483297 19 18 19 3 8 5 0 5 1 0 0.0525 0.908 1.000 296 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), DAG1(2), ITPR1(5), ITPR2(3), ITPR3(5), PDE6A(2), PDE6B(2), SLC6A13(2) 15333172 22 22 22 2 13 6 1 0 2 0 0.00249 0.910 1.000 297 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(1), EPO(1), JAK2(1), NFKB1(1), NFKBIA(1) 5401381 5 5 5 0 2 1 0 2 0 0 0.210 0.912 1.000 298 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(6), NFKB1(1), NFKBIA(1) 7727374 12 11 10 3 2 5 1 3 1 0 0.302 0.913 1.000 299 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(3), GNB1(1), MAPK1(2), MAPK3(1), PRKAR1B(1), PRKAR2B(1), RPS6KA1(1), SRC(2) 8765536 12 12 12 1 5 3 1 3 0 0 0.0641 0.915 1.000 300 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(5), CPT1A(1), LEPR(1), PRKAG2(1) 6135736 8 8 8 2 4 0 0 2 2 0 0.596 0.916 1.000 301 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(1), FUT8(1), ST3GAL1(1) 3343331 3 3 3 0 1 0 0 1 1 0 0.421 0.922 1.000 302 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B3(1), HSD17B4(1) 3431425 3 3 3 2 0 2 0 0 1 0 0.812 0.923 1.000 303 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACYP1(1), ECHS1(1), EHHADH(1), HADHA(1) 3315134 4 4 4 2 0 3 0 0 1 0 0.720 0.928 1.000 304 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CREB1(1), DUSP10(1), ELK1(2), IL1R1(2), MAP2K3(3), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAPK1(2), MAPK13(1), MAPKAPK2(1), NFKB1(1), NR2C2(1), SRF(1) 14238525 24 22 24 4 6 8 5 2 3 0 0.0558 0.932 1.000 305 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDPS(2), MVD(1), MVK(1) 5653473 5 5 5 0 2 0 2 1 0 0 0.190 0.933 1.000 306 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), ANKRD6(2), APC(1), AXIN1(3), AXIN2(1), DACT1(1), DKK1(1), DKK2(3), DVL1(1), FSTL1(1), GSK3B(1), LRP1(9), MVP(3), NKD1(1), PSEN1(1), PTPRA(3), WIF1(1) 17279100 34 31 34 5 13 3 5 8 5 0 0.0255 0.936 1.000 307 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(1), EPHB1(2), FYN(1), ITGA1(2), ITGB1(1), L1CAM(5), LYN(2), SELP(2) 6695594 16 16 16 5 7 2 5 2 0 0 0.384 0.937 1.000 308 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL4R(7), IRS1(4), JAK1(2), JAK3(2), STAT6(1) 6346422 17 17 17 5 6 2 1 4 4 0 0.459 0.943 1.000 309 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 GZMB(2) 4033315 2 2 2 1 0 0 1 0 1 0 0.804 0.945 1.000 310 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(4), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5E(2) 6174722 10 10 9 4 4 2 2 2 0 0 0.526 0.946 1.000 311 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CCL2(1), CCR5(1), FOS(1), PLCG1(6), PRKCA(1), PTK2B(3), SYT1(1) 5838350 15 14 15 5 5 1 2 4 3 0 0.451 0.949 1.000 312 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(2) 2720959 3 3 3 2 2 0 1 0 0 0 0.871 0.951 1.000 313 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDK7(1), SHH(2) 3706422 3 2 3 0 2 1 0 0 0 0 0.306 0.953 1.000 314 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNB1(1), PRKAG2(1), PRKAR1B(1), PRKAR2B(1) 6542846 7 7 7 0 3 1 0 3 0 0 0.130 0.954 1.000 315 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR7(1), FDPS(2), IDI2(1), MVD(1), MVK(1), NQO1(1) 8262742 8 8 8 1 2 1 2 2 1 0 0.301 0.956 1.000 316 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(1), CD3E(2), CD3G(1), CD8A(1), ICAM1(1), ITGB2(4), PTPRC(2) 4552140 13 13 13 9 6 0 1 3 3 0 0.903 0.957 1.000 317 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(2), PCYT1A(2), PDHA1(1), PDHA2(3), SLC18A3(1) 2979972 9 9 9 5 5 1 1 0 2 0 0.681 0.958 1.000 318 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNB1(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1) 4100404 4 4 4 1 2 0 0 2 0 0 0.658 0.959 1.000 319 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), ITGA1(2), ITGB1(1), ITGB3(1), PXN(1), SPTAN1(3), SRC(2) 12127234 16 15 16 1 6 1 1 7 1 0 0.0569 0.960 1.000 320 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), GCNT2(1), ST8SIA1(1) 2618535 3 3 3 2 2 0 0 0 1 0 0.880 0.961 1.000 321 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), CALM1(1), CREB1(1), ELK1(2), FOS(1), GNB1(1), MAP2K1(1), MAPK3(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RAF1(1), RPS6KA3(1), SYT1(1) 14899891 28 27 28 5 9 4 3 7 5 0 0.0766 0.962 1.000 322 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(1), CD3E(2), CD3G(1), CD4(1), ICAM1(1), ITGB2(4), PTPRC(2) 4780462 13 13 13 9 6 0 1 3 3 0 0.908 0.963 1.000 323 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH5A1(1), CAD(3), CPS1(5), EPRS(2), GAD1(1), GFPT1(1), GLS(1), GLUL(1), GOT2(1), GSS(1), NADSYN1(1), QARS(2) 14090013 20 19 20 3 3 4 7 6 0 0 0.0819 0.963 1.000 324 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(3), SCAP(1), SREBF1(1), SREBF2(1) 5130085 6 6 6 2 1 2 0 3 0 0 0.591 0.964 1.000 325 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(1), CREBBP(4), EP300(1), PRKAR1B(1), PRKAR2B(1), RXRA(3) 8789558 12 12 12 3 3 2 1 2 4 0 0.430 0.965 1.000 326 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), HAO1(2), HAO2(1), HYI(1), MTHFD1(1) 5409794 6 6 6 2 1 0 2 3 0 0 0.630 0.966 1.000 327 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNB1(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL1RN(2), IL6(1), IRAK1(2), IRAK2(1), IRAK3(3), MAP2K3(3), MAP3K1(6), MAP3K7(3), NFKB1(1), NFKBIA(1) 12629530 31 29 29 8 7 10 3 6 5 0 0.119 0.967 1.000 328 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GFPT1(1), GNPDA1(1), HK2(2), HK3(2), RENBP(1) 7186008 7 7 7 1 4 0 1 1 1 0 0.373 0.968 1.000 329 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(3), PDHA1(1), PDHA2(3) 4257939 7 7 7 3 2 3 0 1 1 0 0.687 0.968 1.000 330 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(1), EPRS(2), HARS(2), IARS(3), KARS(2), MARS(2), QARS(2), RARS(1), TARS(1), WARS(1) 13586452 18 18 18 3 3 3 3 7 2 0 0.273 0.968 1.000 331 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), LCMT1(1), LCMT2(1), METTL6(1), PCYT1A(2), PCYT1B(1), PRMT8(1) 6025372 8 8 8 2 4 0 0 2 2 0 0.502 0.969 1.000 332 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP6(2), ACPT(2), ALPI(1), ALPP(2), ALPPL2(4), CYP3A4(2), CYP3A43(1), CYP3A7(5), PON1(2) 7656106 21 20 21 7 12 2 3 4 0 0 0.320 0.970 1.000 333 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1) 6399853 11 11 11 4 4 2 1 4 0 0 0.582 0.970 1.000 334 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1) 6399853 11 11 11 4 4 2 1 4 0 0 0.582 0.970 1.000 335 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1) 6399853 11 11 11 4 4 2 1 4 0 0 0.582 0.970 1.000 336 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 OXCT2(1) 3066460 1 1 1 1 1 0 0 0 0 0 0.906 0.971 1.000 337 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(4), EP300(1), IKBKB(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1) 9537925 12 11 12 3 2 3 1 3 3 0 0.349 0.971 1.000 338 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(1), CTH(1), GGT1(1), MARS(2), MAT1A(2), SCLY(1) 5256923 8 7 8 3 2 2 0 3 1 0 0.686 0.972 1.000 339 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST13(1), SULT2B1(1), SUOX(1) 3915718 3 3 3 0 1 1 0 1 0 0 0.348 0.972 1.000 340 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX5(1), CBR1(2), CYP4F2(3), CYP4F3(2), EPX(2), GGT1(1), MPO(2), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(4) 11878641 28 27 28 6 16 2 0 7 3 0 0.102 0.974 1.000 341 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), HAO1(2), HAO2(1), HYI(1), MTHFD1(1) 5668393 6 6 6 2 1 0 2 3 0 0 0.629 0.975 1.000 342 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(3), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(2) 3968502 12 12 12 5 5 3 0 2 2 0 0.680 0.975 1.000 343 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(3), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(2) 3968502 12 12 12 5 5 3 0 2 2 0 0.680 0.975 1.000 344 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(6), C5(1), C6(1), C8A(2), C9(2) 5378702 12 12 12 6 3 1 1 4 3 0 0.839 0.976 1.000 345 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), CAMKK1(1), CREB1(1), SYT1(1) 4945513 7 7 7 4 2 0 1 1 3 0 0.883 0.976 1.000 346 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 PRKCA(1), PSEN1(1) 3810158 2 2 2 0 1 0 0 1 0 0 0.567 0.978 1.000 347 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 DPYD(2), DPYS(1), ENPP1(1) 5926460 4 4 4 1 0 0 0 4 0 0 0.741 0.978 1.000 348 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15B(1), ALOX5(1), DPEP1(2), GGT1(1), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 6426199 11 10 11 3 5 2 0 2 2 0 0.289 0.979 1.000 349 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 SUOX(1) 2575664 1 1 1 0 0 0 0 1 0 0 0.837 0.979 1.000 350 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), CKM(1), NCL(1) 3791724 4 4 4 2 2 0 1 0 1 0 0.795 0.980 1.000 351 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), STX5(1), STX6(1), STX7(1), TSNARE1(2), USE1(1), VAMP5(1), VAMP7(3) 7154300 11 11 11 3 3 0 3 4 1 0 0.509 0.981 1.000 352 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(2) 5783099 6 6 6 2 1 1 1 1 2 0 0.701 0.981 1.000 353 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1) 6811928 11 11 11 4 4 2 1 4 0 0 0.585 0.982 1.000 354 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(1), AXIN1(3), BMP2(1), BMP4(1), BMP5(4), BMPR2(1), CHRD(1), DVL1(1), FZD1(1), GATA4(2), GSK3B(1), MAP3K7(3), NPPA(2), RFC1(1), TGFBR1(2), TGFBR2(2), TGFBR3(1), WNT1(1) 15539058 29 25 29 5 6 6 5 8 4 0 0.0662 0.982 1.000 355 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(1), DDX20(1), E2F4(1), ETS1(2), FOS(1), HDAC2(3), NCOR2(2), RBL1(2), SIN3A(2) 11176943 15 14 15 2 3 3 1 5 3 0 0.206 0.983 1.000 356 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), F10(1), F2(1), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), KLKB1(2), PROS1(2), SERPINC1(1), SERPING1(1) 19031781 57 51 57 15 12 15 8 14 8 0 0.0881 0.983 1.000 357 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CHUK(1), EGR2(2), EGR3(1), MAP3K1(6), NFATC2(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), SYT1(1), VIPR2(1) 11882184 26 23 24 7 6 6 4 6 4 0 0.170 0.984 1.000 358 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), MEF2A(2), MEF2D(1), PPARA(1), PPP3CB(1), SYT1(1), YWHAH(1) 8655592 11 11 11 3 2 2 2 3 2 0 0.412 0.985 1.000 359 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8IP3(3), PAPPA(2), RPS6KA1(1), RPS6KA3(1), SOS1(3), VAV1(4), VAV2(2), VAV3(1) 13697360 32 29 30 8 9 8 6 7 2 0 0.120 0.985 1.000 360 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1) 9956570 8 8 8 1 2 3 2 0 1 0 0.186 0.985 1.000 361 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 BCL2(2), BIRC2(1), BIRC3(1), CASP9(1) 5782774 5 5 5 2 0 0 1 2 2 0 0.928 0.985 1.000 362 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(1), XDH(3) 3376477 6 6 6 5 2 2 0 1 1 0 0.884 0.987 1.000 363 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ARPC2(1) 3446428 1 1 1 1 0 0 0 0 1 0 1.000 0.987 1.000 364 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(1), IL1A(1), IL1R1(2), IRAK1(2), MAP3K1(6), MAP3K7(3), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1) 10417684 21 20 19 6 4 9 2 4 2 0 0.256 0.988 1.000 365 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 NCOA1(1), NCOA2(3), NCOR2(2), POLR2A(2), RXRA(3), TBP(2) 10677473 13 13 13 3 2 2 0 3 6 0 0.443 0.988 1.000 366 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(1), CREBBP(4), EP300(1), MAP2K1(1), MAP3K7(3), MAPK3(1), TGFBR1(2), TGFBR2(2) 10877230 15 15 15 4 1 5 4 1 4 0 0.359 0.988 1.000 367 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(1), HDC(3), TPH1(2) 2586206 7 7 7 4 4 1 0 2 0 0 0.744 0.989 1.000 368 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(3), PDE1A(2), PLCB1(1), PLCB2(3), TRH(1) 4715398 11 11 11 6 3 3 0 3 2 0 0.838 0.990 1.000 369 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(2), CRY1(1), PER1(1) 3644136 4 4 4 3 1 1 0 1 1 0 0.942 0.990 1.000 370 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 BCL2(2), BIRC2(1), BIRC3(1), CASP9(1), CHUK(1), CRADD(1), DAXX(3), GSN(1), LMNB2(1), MAP3K1(6), MAP3K5(1), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(3), PRKCD(3), PRKDC(3), PSEN1(1), RB1(24), RIPK1(1), SPTAN1(3), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1) 29741406 64 60 59 11 9 7 6 11 30 1 0.0251 0.991 1.000 371 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CDKN1A(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1), SP1(1), SP3(1), SYT1(1) 8895994 17 16 17 5 4 4 2 4 3 0 0.308 0.992 1.000 372 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGAP5(3), CASP1(4), CASP10(1), CASP9(1), GZMB(2) 5462603 11 11 10 5 1 2 1 5 2 0 0.773 0.993 1.000 373 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(1), ACADS(3), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), DBT(1), DLD(2), ECHS1(1), EHHADH(1), HADHA(1), HIBCH(1), HSD17B4(1), MCCC1(1), MUT(1), OXCT2(1), PCCA(2), PCCB(1) 18300781 27 26 26 5 12 7 4 2 2 0 0.0402 0.993 1.000 374 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(3), PDHA1(1), PDHA2(3), VARS(1), VARS2(2) 7923155 10 10 10 3 2 3 2 2 1 0 0.461 0.993 1.000 375 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVRL1(1), AKT1(1), AURKB(1), BMPR2(1), BUB1(1), CDKL1(2), CDKL2(2), CSNK2A1(1), CSNK2B(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), NEK1(2), NEK3(2), OCRL(2), PAK4(2), PIK3C2A(1), PIK3C2B(1), PIK3C2G(9), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIM2(2), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCG1(6), PLCG2(3), PLK3(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), TGFBR1(2) 48370830 135 107 129 26 36 27 22 28 22 0 0.000749 0.993 1.000 376 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 HMOX1(1), IL1A(1), IL6(1), JAK1(2), STAT1(2), STAT3(1) 5187339 8 8 8 4 1 2 0 3 2 0 0.743 0.994 1.000 377 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(2), RECK(1), TIMP3(1) 3193896 4 4 4 3 2 0 0 2 0 0 0.877 0.994 1.000 378 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IFNG(2), IL12B(2), IL16(1), IL1A(1), IL3(1), IL6(1) 4196550 9 9 9 5 2 2 1 3 1 0 0.749 0.994 1.000 379 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(2), SOS1(3), SRC(2), ZYX(2) 20099087 28 23 28 3 7 5 6 7 3 0 0.0174 0.994 1.000 380 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), CALM1(1), EPS15(2), PICALM(1), PPP3CB(1), SYNJ2(3), SYT1(1) 9267389 13 13 13 4 7 0 2 2 2 0 0.366 0.994 1.000 381 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), PSEN1(1) 4033736 2 2 2 1 0 0 0 1 1 0 0.931 0.994 1.000 382 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AKR1B10(1), ALAS1(1), AMT(2), AOC2(1), CBS(1), CTH(1), DAO(3), DLD(2), DMGDH(2), GAMT(1), GATM(2), GCAT(1), GLDC(1), MAOA(1), MAOB(2), PHGDH(1), PIPOX(1), PISD(1), PSAT1(2), PSPH(1), SARDH(1), SARS2(1), TARS(1), TARS2(1) 18288677 36 34 36 7 14 7 1 12 2 0 0.0613 0.994 1.000 383 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(4), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), DDC(3), EPX(2), ESCO1(1), GOT2(1), MAOA(1), MAOB(2), MPO(2), TAT(2), TPO(4) 14553304 27 24 26 5 17 3 1 5 1 0 0.0476 0.995 1.000 384 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT2(1), GALNT4(1), GALNT6(1), GALNT7(1), GALNT9(2), GCNT1(2), ST3GAL1(1), WBSCR17(6) 6108802 16 15 16 7 6 3 2 2 3 0 0.724 0.995 1.000 385 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CALM1(1), CAMK2A(1), F2(1), FYN(1), GNB1(1), JAK2(1), MAP2K1(1), MAPK1(2), MAPK3(1), MYLK(2), PLCG1(6), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), STAT1(2), STAT3(1), SYT1(1) 17757280 32 29 32 7 7 3 6 10 6 0 0.118 0.995 1.000 386 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN3(1), CSK(1), CTNNA1(2), CTNNA2(2), PXN(1), SRC(2) 8156079 11 10 11 3 2 3 1 4 1 0 0.495 0.995 1.000 387 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF2(2), HLA-DRA(1), IFNB1(1), IFNG(2), IL12B(2), IL1A(1), IL3(1), IL6(1), IL7(1) 5671762 13 13 13 6 4 3 2 2 2 0 0.622 0.996 1.000 388 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ARPC2(1), NCKAP1(1), NTRK1(1), WASF3(1) 6482448 4 4 4 5 0 0 1 0 3 0 0.994 0.996 1.000 389 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1S(3), C3(6), C5(1), C6(1), C8A(2), C8B(3), C9(2) 8921312 18 18 18 6 5 4 1 5 3 0 0.486 0.997 1.000 390 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(3), PGM1(1), PYGL(1), PYGM(1), TREH(1) 5704517 7 7 7 3 3 2 1 1 0 0 0.588 0.997 1.000 391 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 IMPDH1(2), POLD1(1), PRPS2(2) 5369314 5 5 5 2 4 0 0 1 0 0 0.680 0.997 1.000 392 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(1), PSMA5(1), PSMC3(1) 6771467 3 3 3 1 0 1 1 0 1 0 0.747 0.997 1.000 393 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(1), PSMA5(1), PSMC3(1), UBE3A(1) 5484648 4 4 4 2 0 1 2 0 1 0 0.810 0.998 1.000 394 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ACADS(3), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), PDHA1(1), PDHA2(3) 10954598 20 20 20 7 8 6 1 2 3 0 0.337 0.998 1.000 395 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD28(1), CSK(1), DAG1(2), DTYMK(1), EPHB2(3), FBXW7(1), GRAP2(1), MAPK1(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PAK1(1), PAK4(2), PAK7(1), PLCG1(6), PTPRC(2), RAF1(1), RASGRP1(1), RASGRP2(1), RASGRP4(1), SOS1(3), VAV1(4), ZAP70(3) 23896489 44 42 44 9 13 7 7 11 6 0 0.0711 0.998 1.000 396 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(4), AOC2(1), CES1(2), ESCO1(1), PLA1A(1), PPME1(1) 10789490 11 11 11 3 7 2 0 2 0 0 0.353 0.998 1.000 397 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(1), AGTR1(1), AGTR2(1), CMA1(1), COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), REN(5) 10871720 30 27 29 10 9 9 4 4 4 0 0.325 0.998 1.000 398 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(4), EPRS(2), FECH(1), HCCS(1), HMBS(1), HMOX1(1), PPOX(1), UGT1A1(7), UGT2B15(1), UGT2B4(5) 11620354 24 23 24 7 7 4 2 8 3 0 0.350 0.998 1.000 399 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1) 10214287 6 6 6 1 2 1 1 1 1 0 0.458 0.998 1.000 400 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), CHAT(2), DBH(1), DDC(3), GAD1(1), HDC(3), MAOA(1), PAH(2), SLC18A3(1), TPH1(2) 6149632 17 16 17 7 10 1 2 4 0 0 0.493 0.998 1.000 401 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1S(3), C3(6), C5(1), C6(1), C8A(2), C9(2) 7526996 15 15 15 6 4 2 1 5 3 0 0.697 0.999 1.000 402 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(4), ADC(2), ALDH1A3(1), ALDH3A1(2), AMD1(2), AOC2(1), ASS1(1), CPS1(5), GATM(2), MAOA(1), MAOB(2), NAGS(1), OTC(2) 12590336 26 26 26 8 10 3 4 8 1 0 0.406 0.999 1.000 403 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(1), AXIN1(3), BTRC(1), DLL1(1), DVL1(1), FZD1(1), GSK3B(1), PSEN1(1), WNT1(1) 9219499 11 10 11 4 1 1 1 5 3 0 0.767 0.999 1.000 404 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR2(4), HLA-DRA(1), ICAM1(1), ITGB2(4), PTPRC(2) 6474045 12 11 12 9 6 1 0 3 2 0 0.935 0.999 1.000 405 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(4), ACY3(1), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), CARM1(1), CNDP1(2), DDC(3), HAL(2), HARS(2), HDC(3), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), PRMT8(1), PRPS2(2), UROC1(1) 16900789 33 29 33 6 20 2 1 9 1 0 0.0322 0.999 1.000 406 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), B4GALT2(1), DPM1(1), FUT8(1), MAN1A1(1), MGAT2(1), MGAT5(1), ST6GAL1(1) 8442453 9 9 9 3 4 1 0 2 2 0 0.471 0.999 1.000 407 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 MAP2K3(3), NFATC2(2), PRKAR1B(1), PRKAR2B(1) 5203117 7 6 7 5 4 0 0 1 2 0 0.743 0.999 1.000 408 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CACNA1C(5), CACNA1D(4), CACNA1F(1), CACNA1S(7), CALM1(1), CAMK2A(1), CGA(1), EGFR(92), ELK1(2), GNRHR(1), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K4(3), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), NRAS(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PLD1(1), PRKCA(1), PRKCD(3), PRKX(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2) 54614822 200 138 148 37 56 71 9 50 14 0 1.06e-07 0.999 1.000 409 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(1), COX10(2), CP(4), EPRS(2), FECH(1), FTMT(4), HCCS(1), HMBS(1), HMOX1(1), MMAB(1), PPOX(1), UGT1A1(7), UGT2A1(4), UGT2A3(6), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B28(6), UGT2B4(5), UGT2B7(2) 17943982 56 47 55 15 17 7 9 18 5 0 0.194 0.999 1.000 410 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ESR1(1), MTA1(1), MTA3(1), TUBA8(1) 4716140 4 4 4 5 2 0 0 1 1 0 0.949 0.999 1.000 411 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1C4(2), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), CEL(2), CYP27A1(1), CYP7A1(1), SRD5A1(1), SRD5A2(1) 9900631 21 20 21 8 8 5 1 7 0 0 0.497 0.999 1.000 412 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(1), CBS(1), CTH(1), GGT1(1), LCMT1(1), LCMT2(1), MARS(2), MAT1A(2), METTL6(1), PRMT8(1), SCLY(1) 10615379 13 12 13 4 5 2 0 4 2 0 0.528 0.999 1.000 413 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(1), CYP11A1(3), HPGD(1), HSD11B1(2), PLA2G4A(3), PTGER4(1), PTGFR(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 8779969 17 17 17 6 7 2 0 4 4 0 0.473 0.999 1.000 414 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 RPE(1), UGT1A1(7), UGT2B15(1), UGT2B4(5) 7463800 14 14 14 8 5 4 0 3 2 0 0.808 0.999 1.000 415 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(4), CARM1(1), CREBBP(4), EP300(1), ESR1(1), GRIP1(7), HDAC2(3), HDAC4(1), HDAC6(1), NCOR2(2), NRIP1(2), POLR2A(2), TBP(2) 19805182 31 29 31 7 8 10 2 5 6 0 0.0964 1.000 1.000 416 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(4), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), AOX1(4), DBH(1), DCT(1), DDC(3), GOT2(1), MAOA(1), MAOB(2), TAT(2), TPO(4), TYR(1) 13500254 35 32 33 10 22 3 2 8 0 0 0.114 1.000 1.000 417 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR2(1), MTNR1B(1), PTAFR(1), PTGER4(1), PTGFR(1) 4810181 5 5 5 9 3 0 0 1 1 0 0.996 1.000 1.000 418 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPL13(1), RPL10L(2), RPL11(2), RPL13A(1), RPL22L1(1), RPL3L(1), RPL7(1), RPS12(1), RPS21(1), RPS5(1), RPSA(2) 9721608 15 14 15 6 4 0 2 3 6 0 0.901 1.000 1.000 419 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), NFKB1(1) 6209163 2 2 2 2 1 0 0 0 1 0 0.888 1.000 1.000 420 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(1), CETP(2), CYP7A1(1), DGAT1(2), LCAT(1), LDLR(3), LRP1(9), SCARB1(1), SOAT1(3) 11638665 23 22 23 8 5 3 2 6 7 0 0.573 1.000 1.000 421 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 AMT(2), MTHFD1(1), MTHFR(1) 7601920 4 4 4 2 1 0 2 0 1 0 0.802 1.000 1.000 422 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), BTK(1), CARD11(5), CD19(1), CD22(6), CHUK(1), CR2(4), FOS(1), GSK3B(1), IFITM1(1), IKBKB(1), INPP5D(3), KRAS(2), LILRB3(7), LYN(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NRAS(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG2(3), PPP3CB(1), PTPN6(1), VAV1(4), VAV2(2), VAV3(1) 31745776 145 109 133 31 35 29 15 31 35 0 0.00451 1.000 1.000 423 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), GNB1(1), MYLK(2), PLCB1(1), PPP1R12B(1), PRKCA(1), ROCK1(2) 8792612 11 11 10 6 2 1 0 5 3 0 0.910 1.000 1.000 424 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(3), EPHB2(3), F2(1), F2RL3(2), MAPK1(2), MAPK7(1), PLD1(1), RAF1(1), RASAL1(1), SRC(2), TEC(1), VAV1(4) 11713207 23 22 23 7 8 5 3 5 2 0 0.323 1.000 1.000 425 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ASNS(2), CAD(3), CRAT(1), DARS(1), GAD1(1), GOT2(1), PC(2) 11072827 12 12 12 4 0 3 3 4 2 0 0.611 1.000 1.000 426 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AOC2(1), CNDP1(2), DPYD(2), DPYS(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), MLYCD(1) 12340731 21 20 21 7 10 5 0 5 1 0 0.299 1.000 1.000 427 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAD8(2), ADH1A(2), ADH1B(2), ADH1C(2), AKR1B10(1), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), CEL(2), CYP27A1(1), CYP7A1(1), SOAT1(3), SRD5A1(1), SRD5A2(1) 13545307 24 22 24 8 7 6 1 9 1 0 0.452 1.000 1.000 428 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1S(3), C3(6), C5(1), C6(1), C8A(2), C9(2), MASP2(1), MBL2(1) 9148335 17 17 17 7 4 3 1 6 3 0 0.682 1.000 1.000 429 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 DIAPH2(3), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), NACA(1), POLA2(1), POLD1(1), POLD4(1), POLE2(1), PRIM1(1), RFC1(1), RFC4(1), RPA2(1), RPA4(2), UBA52(1), UBC(3) 21685413 30 30 30 6 7 6 4 9 4 0 0.142 1.000 1.000 430 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(6), CREB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), NFKB1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SOS1(3) 12609086 19 18 15 5 4 3 2 8 2 0 0.475 1.000 1.000 431 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(8), CALCRL(1), CD97(1), CRHR2(2), ELTD1(5), EMR1(1), EMR2(1), GHRHR(1), GLP1R(1), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(1), LPHN3(2), VIPR2(1) 11485231 30 27 30 10 14 1 4 9 2 0 0.371 1.000 1.000 432 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(1), APC2(3), AXIN1(3), AXIN2(1), BTRC(1), CAMK2A(1), CCND2(2), CCND3(1), CHD8(9), CREBBP(4), CSNK2A1(1), CSNK2B(2), CTBP2(3), CUL1(3), CXXC4(1), DAAM2(1), DKK1(1), DKK2(3), DVL1(1), DVL2(2), DVL3(1), EP300(1), FBXW11(1), FZD1(1), FZD10(3), FZD9(1), GSK3B(1), LRP6(2), MAP3K7(3), MMP7(2), NFATC2(2), NFATC4(2), NKD1(1), PLCB1(1), PLCB2(3), PLCB4(1), PORCN(3), PPP2R1B(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PSEN1(1), ROCK1(2), ROCK2(1), RUVBL1(2), SMAD4(1), SOX17(1), TBL1X(1), TCF7L2(1), TP53(96), VANGL1(1), WIF1(1), WNT1(1), WNT10A(2), WNT11(1), WNT2(5), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1) 69056642 202 142 165 32 66 29 22 43 42 0 1.74e-07 1.000 1.000 433 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 DPYD(2), DPYS(1), ENPP1(1) 7355325 4 4 4 2 0 0 0 4 0 0 0.875 1.000 1.000 434 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 AMT(2), MTHFD1(1), MTHFR(1) 8061615 4 4 4 2 1 0 2 0 1 0 0.803 1.000 1.000 435 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 BCL2(2), BIRC2(1), BIRC3(1), CASP10(1), CASP9(1), CHUK(1), NFKB1(1), NFKBIA(1), RIPK1(1), SPTAN1(3), TNFRSF25(1), TNFSF10(2) 14276736 16 15 16 4 4 0 2 6 4 0 0.491 1.000 1.000 436 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 RPE(1), UGT1A1(7), UGT2A1(4), UGT2A3(6), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B28(6), UGT2B4(5), UGT2B7(2), XYLB(1) 11568151 39 36 38 13 11 5 7 12 4 0 0.433 1.000 1.000 437 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(1), IFNG(2), IKBKB(1), MAP3K1(6), MAP3K5(1), NFKB1(1), NFKBIA(1), TNFRSF9(1), TNFSF9(3) 8277615 17 15 14 8 5 5 3 2 2 0 0.622 1.000 1.000 438 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(1), ELK1(2), FOS(1), IKBKB(1), IRAK1(2), LY96(2), MAP2K3(3), MAP3K1(6), MAP3K7(3), NFKB1(1), NFKBIA(1), PPARA(1), TLR10(2), TLR2(4), TLR3(1), TLR6(5), TLR7(4), TLR9(2) 15573783 42 40 40 12 14 11 4 8 5 0 0.166 1.000 1.000 439 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), ADH1C(2), AGPAT1(2), AGPAT2(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), CEL(2), DGAT1(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), GK(2), LCT(3), LIPF(1), LIPG(1), PNLIP(1) 20626882 42 40 42 11 17 8 0 12 5 0 0.103 1.000 1.000 440 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(1), ASAH1(1), CREB1(1), DAG1(2), EPHB2(3), FOS(1), MAPK1(2), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3) 12151575 17 17 17 5 5 3 6 1 2 0 0.373 1.000 1.000 441 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22(2), JAK1(2), JAK2(1), JAK3(2), STAT1(2), STAT3(1), TYK2(3) 7886078 13 13 13 5 6 1 0 4 2 0 0.594 1.000 1.000 442 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(5), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), HADHA(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG1(2) 14028566 23 22 23 7 9 6 2 4 2 0 0.351 1.000 1.000 443 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ELOVL2(1), HADHA(1) 6166667 3 3 3 2 1 2 0 0 0 0 0.672 1.000 1.000 444 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), BTK(1), GSK3B(1), LYN(2), PFKL(1), PLCG1(6), PRKCE(1), VAV2(2) 10701992 15 14 15 5 3 5 3 3 1 0 0.368 1.000 1.000 445 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(2), ADH1C(2), AKR1C3(1), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), CYP1A2(2), CYP1B1(1), CYP2B6(4), CYP2C19(2), CYP2C8(2), CYP2E1(1), CYP2F1(1), CYP2S1(1), CYP3A4(2), CYP3A43(1), CYP3A7(5), EPHX1(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(1), UGT1A1(7), UGT2A1(4), UGT2A3(6), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B28(6), UGT2B4(5), UGT2B7(2) 24363801 79 68 78 22 29 10 9 25 6 0 0.0962 1.000 1.000 446 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ADC(2), ALDH5A1(1), CAD(3), CPS1(5), EPRS(2), GAD1(1), GFPT1(1), GLS(1), GLUD2(3), GLUL(1), GOT2(1), GSS(1), NADSYN1(1), QARS(2) 16786049 25 24 25 6 5 4 7 8 1 0 0.246 1.000 1.000 447 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(1), ANAPC4(2), ANAPC7(1), BTRC(1), CDC23(2), CDC27(1), CUL1(3), CUL2(1), FBXW11(1), FBXW7(1), FZR1(1), ITCH(1), SKP2(1), SMURF1(2), UBE2E3(1), WWP2(1) 17210939 21 21 21 5 4 2 4 6 5 0 0.385 1.000 1.000 448 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(1), ACYP1(1), ECHS1(1), EHHADH(1), ESCO1(1), HADHA(1), ITGB1BP3(1), YOD1(1) 11027242 8 8 8 3 3 4 0 0 1 0 0.521 1.000 1.000 449 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE2(1), POLI(2), POLL(1), POLQ(3), PRIM1(1), PRIM2(1), REV1(2), REV3L(1) 17420081 16 16 16 4 5 2 1 7 1 0 0.488 1.000 1.000 450 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(1), DRD1(1), DRD2(1), GRM1(3), PLCB1(1), PPP1R1B(1), PRKAR1B(1), PRKAR2B(1) 6817871 10 10 10 5 6 1 0 2 1 0 0.762 1.000 1.000 451 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(1), AXIN1(3), BTRC(1), CREBBP(4), CSNK1D(1), CSNK2A1(1), DVL1(1), FZD1(1), GSK3B(1), MAP3K7(3), WIF1(1), WNT1(1) 12553660 19 18 19 7 1 4 3 5 6 0 0.684 1.000 1.000 452 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 CREB1(1), EP300(1), EPO(1), NOS3(3), P4HB(1) 7292594 7 7 7 5 4 1 0 1 1 0 0.910 1.000 1.000 453 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(2), BDKRB1(1), C1QC(1), C1S(3), C3(6), C4BPB(1), C5(1), C5AR1(3), C6(1), C8A(2), C8B(3), C9(2), CD46(2), CD55(1), CD59(1), CFB(3), CFH(7), CFI(1), CR2(4), F10(1), F13A1(3), F13B(1), F2(1), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), KLKB1(2), KNG1(2), MASP2(1), MBL2(1), PLAT(2), PLG(2), PROS1(2), SERPINA1(2), SERPINA5(1), SERPINC1(1), SERPINE1(2), SERPING1(1), VWF(7) 38603215 107 87 107 28 33 21 12 27 14 0 0.0222 1.000 1.000 454 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT8(1) 6402718 5 5 5 3 3 0 0 1 1 0 0.844 1.000 1.000 455 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 AKT1(1), DAG1(2), ITPR1(5), ITPR2(3), ITPR3(5), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PIK3CB(4), PITX2(3), PLD1(1) 19182003 29 25 29 7 8 10 3 5 3 0 0.0800 1.000 1.000 456 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(1), POLL(1), POLQ(3) 7105957 5 5 5 3 2 0 0 3 0 0 0.918 1.000 1.000 457 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), ATP7A(3), COX10(2), COX7C(1), NDUFA10(1), NDUFA4(1), NDUFS2(1), PPA2(1), UQCRC1(1) 16248082 22 22 22 6 6 5 2 8 1 0 0.285 1.000 1.000 458 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), CARD11(5), CBL(1), CBLB(1), CD28(1), CD3E(2), CD3G(1), CD4(1), CD8A(1), CHUK(1), CSF2(2), FOS(1), FYN(1), GRAP2(1), IFNG(2), IKBKB(1), KRAS(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NRAS(1), PAK1(1), PAK4(2), PAK7(1), PDCD1(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PPP3CB(1), PRKCQ(2), PTPN6(1), PTPRC(2), RASGRP1(1), SOS1(3), TEC(1), VAV1(4), VAV2(2), VAV3(1), ZAP70(3) 43265931 153 116 141 30 33 27 22 34 37 0 0.00292 1.000 1.000 459 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(1), LCT(3), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC4(1), ST8SIA1(1) 6983981 9 9 9 8 3 2 0 3 1 0 0.963 1.000 1.000 460 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CHUK(1), CRADD(1), IKBKB(1), MAP2K3(3), MAP3K1(6), MAP4K2(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1) 10334529 17 15 15 9 5 5 1 3 3 0 0.788 1.000 1.000 461 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(4), ALAS1(1), AMT(2), AOC2(1), CBS(1), CTH(1), DAO(3), DLD(2), DMGDH(2), GAMT(1), GATM(2), GCAT(1), GLDC(1), MAOA(1), MAOB(2), PISD(1), PLCB2(3), PLCG1(6), PLCG2(3), PSPH(1), SARDH(1), TARS(1) 17967745 41 35 41 10 15 7 2 14 3 0 0.112 1.000 1.000 462 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH1C(2), AGPAT1(2), AGPAT2(1), AGPAT6(1), AKR1A1(1), ALDH1A3(1), ALDH3A1(2), CEL(2), DGAT1(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), GK(2), GK2(1), LCT(3), LIPF(1), LIPG(1), PNLIP(1) 25093263 43 42 43 10 17 7 0 13 6 0 0.0683 1.000 1.000 463 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), ABCG2(2), BCHE(2), CES1(2), CYP3A4(2), UGT1A1(7) 9660684 16 16 16 9 9 1 2 2 2 0 0.695 1.000 1.000 464 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AMD1(2), AOC2(1), CKB(1), CKM(1), CKMT1B(2), CPS1(5), DAO(3), GAMT(1), GATM(2), GOT2(1), MAOA(1), MAOB(2), NOS1(5), NOS3(3), OTC(2), P4HB(1), RARS(1) 18935361 44 41 44 12 23 7 5 9 0 0 0.0942 1.000 1.000 465 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(2), FOS(1), JAK1(2), JAK3(2), MAP2K1(1), MAPK3(1), RAF1(1), SOS1(3) 10029991 14 14 14 7 4 1 2 4 3 0 0.892 1.000 1.000 466 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(2), CRY1(1), CSNK1D(1), PER1(1), PER2(3), PER3(1) 7293507 9 9 9 5 4 3 0 1 1 0 0.815 1.000 1.000 467 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(6), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1B(1), TRAF1(1) 9558723 15 14 13 6 4 5 1 4 1 0 0.529 1.000 1.000 468 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ADH1A(2), ADH1B(2), ADH1C(2), ESCO1(1) 10617885 9 8 9 4 2 2 0 5 0 0 0.762 1.000 1.000 469 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(1), CTH(1), MARS(2), MAT1A(2) 7421086 6 6 6 6 2 1 0 2 1 0 0.980 1.000 1.000 470 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), BIRC3(1), MAP3K7(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1) 11604415 15 14 15 5 2 3 4 5 1 0 0.532 1.000 1.000 471 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CALM1(1), CAPNS1(1), EP300(1), HDAC2(3), MEF2D(1), NFATC2(2), PPP3CB(1), PRKCA(1), SYT1(1) 10342087 17 17 17 7 5 3 3 3 3 0 0.578 1.000 1.000 472 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT2(1), EXTL1(1), HS3ST1(2), HS3ST3A1(2), NDST3(1), NDST4(6) 8844888 13 12 13 5 5 1 5 2 0 0 0.559 1.000 1.000 473 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(1), AXIN1(3), CREBBP(4), DVL1(1), EP300(1), FZD1(1), GSK3B(1), PITX2(3), TRRAP(6), WNT1(1) 14119985 22 21 22 9 3 5 3 5 6 0 0.702 1.000 1.000 474 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(2), ARSE(3), CARM1(1), CYP11B1(1), CYP11B2(2), CYP19A1(2), HSD11B1(2), HSD17B3(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT8(1), SRD5A1(1), SRD5A2(1), STS(2), SULT2B1(1), UGT1A1(7), UGT2A1(4), UGT2A3(6), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B28(6), UGT2B4(5), UGT2B7(2) 21414157 60 50 59 19 20 10 8 16 6 0 0.224 1.000 1.000 475 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), DLG4(3), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), NOS1(5), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), SYT1(1) 10898738 30 28 30 11 21 1 2 5 1 0 0.330 1.000 1.000 476 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADS(3), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), ECHS1(1), EHHADH(1), HADHA(1), MCCC1(1), MUT(1), PCCA(2), PCCB(1) 15276879 24 23 23 9 12 5 4 2 1 0 0.357 1.000 1.000 477 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ASS1(1), CKB(1), CKM(1), CKMT1B(2), CPS1(5), DAO(3), EPRS(2), GAMT(1), GATM(2), GLUD2(3), GOT2(1), NOS1(5), NOS3(3), OTC(2), PARS2(1), PRODH(1), RARS(1) 15382884 35 33 35 10 18 4 6 7 0 0 0.201 1.000 1.000 478 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(2), CBS(1), CTH(1), MARS(2), MAT1A(2), TAT(2) 8827527 10 10 9 6 5 2 0 2 1 0 0.848 1.000 1.000 479 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), ARHGEF11(2), BCL2(2), DLG4(3), LPA(4), MAP3K1(6), MAP3K5(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PIK3CB(4), PLD1(1), ROCK1(2), ROCK2(1), SRF(1) 20898391 33 28 31 9 7 12 3 6 5 0 0.253 1.000 1.000 480 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), P4HB(1), SLC23A1(1), SLC2A1(2), SLC2A3(2) 10827827 25 23 25 10 7 7 4 4 3 0 0.421 1.000 1.000 481 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(1), DARS(1), EPRS(2), FARSA(1), HARS(2), IARS(3), KARS(2), MARS(2), PARS2(1), QARS(2), RARS(1), SARS2(1), TARS(1), TARS2(1), VARS(1), VARS2(2), WARS(1), YARS2(1) 23078027 27 27 27 6 4 4 5 10 4 0 0.368 1.000 1.000 482 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CSNK1D(1), DRD1(1), DRD2(1), EGF(3), EGFR(92), GJD2(3), GRM1(3), GRM5(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), HTR2A(1), HTR2C(1), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MAPK7(1), NPR1(1), NRAS(1), PDGFD(2), PDGFRA(14), PDGFRB(3), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(5), PRKX(1), RAF1(1), SOS1(3), SRC(2), TJP1(3), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1) 56377776 214 145 163 43 56 71 13 55 19 0 7.39e-07 1.000 1.000 483 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(1), B4GALT2(1), G6PC(1), GAA(1), GALE(2), GALK1(1), GALK2(1), GALT(1), HK2(2), HK3(2), LCT(3), MGAM(6), PFKL(1), PGM1(1) 16526838 24 23 24 8 12 4 2 4 2 0 0.325 1.000 1.000 484 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(2), ADCY3(3), ADCY9(4), AK1(1), ARL4D(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), PLCG1(6), PLCG2(3), PRKCA(1), TRIM23(1) 15729483 33 31 33 10 11 7 3 8 4 0 0.293 1.000 1.000 485 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTN1(2), ACTN3(1), ACVR1C(2), CREBBP(4), CSNK2A1(1), CSNK2B(2), CTNNA1(2), CTNNA2(2), CTNNA3(2), EGFR(92), EP300(1), ERBB2(1), FGFR1(1), FYN(1), IGF1R(3), INSR(2), LMO7(2), MAP3K7(3), MAPK1(2), MAPK3(1), MET(3), MLLT4(3), PARD3(1), PTPN6(1), PTPRB(3), PTPRF(5), PTPRJ(1), PTPRM(3), PVRL1(2), PVRL2(1), PVRL4(3), SMAD4(1), SNAI2(2), SORBS1(2), SRC(2), TCF7L2(1), TGFBR1(2), TGFBR2(2), TJP1(3), WAS(1), WASF3(1) 50904973 170 122 122 36 29 59 13 51 18 0 0.000298 1.000 1.000 486 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(8), CDR1(1), DGKI(2), FAU(1), RPL10(2), RPL11(2), RPL13A(1), RPL15(1), RPL3L(1), RPL5(7), RPL7(1), RPLP0(1), RPS12(1), RPS21(1), RPS4X(1), RPS5(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), RPSA(2), SLC36A2(2), TBC1D10C(1), TSPAN9(1), UBA52(1), UBC(3) 22429050 48 44 48 10 12 7 7 10 12 0 0.183 1.000 1.000 487 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CYB5R1(1), GFPT1(1), GNPDA1(1), HK2(2), HK3(2), LHPP(1), MTMR1(2), NPL(1), RENBP(1) 12184271 13 13 13 5 7 0 3 2 1 0 0.667 1.000 1.000 488 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTN1(2), ACTN3(1), AKT1(1), AMOTL1(1), CGN(1), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CSDA(1), CSNK2A1(1), CSNK2B(2), CTNNA1(2), CTNNA2(2), CTNNA3(2), CTTN(2), EPB41(1), EPB41L2(1), EPB41L3(5), F11R(1), HCLS1(3), INADL(2), KRAS(2), LLGL1(2), MAGI1(2), MAGI2(2), MAGI3(1), MLLT4(3), MPDZ(1), MYH1(6), MYH10(1), MYH11(5), MYH13(8), MYH14(3), MYH15(3), MYH2(9), MYH3(2), MYH4(5), MYH6(2), MYH7(2), MYH7B(3), MYH8(7), MYH9(3), NRAS(1), OCLN(1), PARD3(1), PARD6B(2), PPM1J(2), PPP2R1B(1), PPP2R3A(2), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PTEN(90), SPTAN1(3), SRC(2), SYMPK(3), TJAP1(2), TJP1(3), TJP3(5) 82774746 239 164 220 41 74 41 24 40 60 0 1.94e-06 1.000 1.000 489 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), AGTR2(1), ATP8A1(2), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), CCKAR(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CX3CR1(2), FSHR(1), GALR1(1), GALT(1), GHSR(2), GNRHR(1), GPR77(1), GRPR(1), LHCGR(2), MC2R(2), MC3R(4), MC4R(3), MC5R(2), NMBR(1), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), PPYR1(1), SSTR2(1), SSTR3(1), SSTR4(4), TACR3(4), TSHR(1) 22211211 66 64 66 23 42 9 3 11 1 0 0.0678 1.000 1.000 490 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(4), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), AOX1(4), CARM1(1), DBH(1), DCT(1), DDC(3), ESCO1(1), GOT2(1), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), PRMT8(1), TAT(2), TPO(4), TYR(1), TYRP1(2) 25323263 43 39 40 11 25 4 2 9 3 0 0.0926 1.000 1.000 491 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 FUCA1(4), GBA(1), HGSNAT(1), HPSE(3), HPSE2(2), LCT(3), MAN2B1(5), MAN2B2(2), NEU1(1), NEU2(3), NEU4(2), SPAM1(4) 14776567 31 29 30 10 12 6 1 10 2 0 0.297 1.000 1.000 492 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(1), FBP1(2), FBP2(1), HK2(2), HK3(2), PFKFB1(2), PFKFB4(1), PMM1(1) 10201544 12 11 12 9 7 1 1 2 1 0 0.909 1.000 1.000 493 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 BCL2(2), BCL2A1(1), BOK(1), CASP1(4), CASP10(1), CASP9(1), CRADD(1), DAXX(3), MCL1(1), NFKB1(1), NFKBIA(1), NTRK1(1), PTPN13(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1) 18685366 23 22 23 9 5 4 1 7 6 0 0.726 1.000 1.000 494 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(1), CALM1(1), ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK3(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4) 16260863 36 32 34 12 8 9 7 7 5 0 0.290 1.000 1.000 495 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CDK7(1), GTF2H1(2), GTF2H4(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), TAF6(1), TAF7(1), TBP(2) 14853277 15 14 15 7 2 4 2 4 3 0 0.799 1.000 1.000 496 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(1), ACY3(1), ASNS(2), ASS1(1), CAD(3), CRAT(1), DARS(1), DLD(2), GAD1(1), GOT2(1), PC(2), PDHA1(1), PDHA2(3) 16104224 21 21 21 9 4 6 3 4 4 0 0.718 1.000 1.000 497 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(1), CLOCK(2), CRY1(1), GFRA1(1), HERPUD1(1), KLF9(1), NCKAP1(1), PER1(1), PER2(3), PIGF(1), SF3A3(1), ZFR(2) 15588634 16 15 16 6 7 2 2 2 3 0 0.615 1.000 1.000 498 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CAMK1(1), ELK1(2), GNB1(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), NCF1(1), NCF2(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PAK1(1), PIK3C2G(9), PLCB1(1), PPP3CB(1), RAF1(1), SYT1(1) 16375701 41 39 39 14 13 8 7 5 8 0 0.317 1.000 1.000 499 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLD(2), IDH3A(1), PC(2), PDHA1(1), PDHA2(3), PDK4(1), PDP2(1), SUCLA2(1), SUCLG1(2) 12078594 14 13 14 7 3 6 0 4 1 0 0.735 1.000 1.000 500 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(1), ASAH1(1), CAV3(1), DAG1(2), DLG4(3), EPHB2(3), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PITX2(3), RYR1(4) 19660407 37 35 37 11 16 11 4 3 3 0 0.0809 1.000 1.000 501 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(1), ALDH3A1(2), CYP2C19(2), ECHS1(1), EHHADH(1), ESCO1(1), HADHA(1), YOD1(1) 13137748 11 11 11 5 5 4 0 1 1 0 0.571 1.000 1.000 502 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(1), AXIN1(3), CCND2(2), CCND3(1), DVL1(1), DVL2(2), DVL3(1), FZD1(1), FZD10(3), FZD9(1), GSK3B(1), LDLR(3), PPP2R5E(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), WNT1(1), WNT10A(2), WNT11(1), WNT2(5), WNT2B(1), WNT3(1), WNT5B(1) 25571788 43 39 42 12 13 6 6 10 8 0 0.223 1.000 1.000 503 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), AKAP1(1), AKAP11(1), AKAP4(2), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(5), CALM1(1), GNAO1(1), GNB1(1), GNG5(1), GNGT2(1), ITPR1(5), KCNJ3(1), KRAS(2), NRAS(1), PDE1A(2), PDE1C(4), PDE4A(2), PDE4B(1), PDE8A(1), PDE8B(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), PRKD3(2) 49897435 78 63 76 15 27 18 8 15 10 0 0.00370 1.000 1.000 504 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), CTTN(2), EZR(4), FYN(1), HCLS1(3), ITGB1(1), KRT18(2), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1), WAS(1) 22331141 37 34 37 12 17 7 6 5 2 0 0.227 1.000 1.000 505 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), CTTN(2), EZR(4), FYN(1), HCLS1(3), ITGB1(1), KRT18(2), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1), WAS(1) 22331141 37 34 37 12 17 7 6 5 2 0 0.227 1.000 1.000 506 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 AGPAT1(2), AGPAT2(1), AGPAT6(1), CHAT(2), CRLS1(1), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), ESCO1(1), GNPAT(1), GPD2(1), LCAT(1), PCYT1A(2), PCYT1B(1), PISD(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLD1(1), PTDSS1(3) 28043803 41 40 41 11 16 7 2 13 3 0 0.163 1.000 1.000 507 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(4), ACMSD(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AOC2(1), AOX1(4), ASMT(1), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(4), CYP2C19(2), CYP2C8(2), CYP2D6(2), CYP2E1(1), CYP2F1(1), CYP3A4(2), CYP3A7(5), CYP4B1(4), CYP4F8(3), DDC(3), ECHS1(1), EHHADH(1), HADHA(1), KYNU(1), MAOA(1), MAOB(2), TPH1(2), WARS(1) 23400697 62 52 61 19 36 6 5 12 3 0 0.116 1.000 1.000 508 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF2(1), EIF2AK2(1), EIF2AK3(1), EIF2B1(1), EIF2S2(1), EIF2S3(2), EIF4A1(1), EIF4G1(1), EIF4G3(1), EIF5B(1), GSPT2(2), PABPC3(4) 18717702 17 17 17 9 5 3 1 5 3 0 0.893 1.000 1.000 509 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CALM1(1), CAMK2A(1), CREB1(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), CREBBP(4), DCT(1), DVL1(1), DVL2(2), DVL3(1), EP300(1), FZD1(1), FZD10(3), FZD9(1), GNAO1(1), GSK3B(1), KIT(3), KITLG(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), TCF7L2(1), TYR(1), TYRP1(2), WNT1(1), WNT10A(2), WNT11(1), WNT2(5), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1) 46471678 90 80 88 23 35 18 11 15 11 0 0.0203 1.000 1.000 510 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), ESR1(1), ESR2(3), HNF4A(4), NPM1(1), NR1H2(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2F2(2), NR4A1(2), NR5A2(1), PGR(5), PPARA(1), PPARG(1), RARB(1), RORC(3), RXRA(3), THRA(1) 17953939 35 34 35 12 12 5 3 11 4 0 0.522 1.000 1.000 511 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(5), ACYP1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), DLD(2), HAGH(1), ME1(1), ME2(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1) 15714288 27 26 27 10 13 5 0 7 2 0 0.483 1.000 1.000 512 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(1), ALG3(2), B4GALT2(1), DPM1(1), FUT8(1), MAN1A1(1), MGAT2(1), MGAT5(1), MGAT5B(1), ST6GAL1(1) 18093370 12 12 12 8 5 3 0 2 2 0 0.855 1.000 1.000 513 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADS(3), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(4), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1) 20808895 29 27 29 10 12 4 2 7 4 0 0.386 1.000 1.000 514 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(2), AKT1(1), ANGPTL2(1), CFL2(1), FLNA(5), FLNC(3), FSCN2(1), GDI1(1), MYH2(9), MYLK(2), PAK1(1), PAK4(2), PAK7(1), ROCK1(2), ROCK2(1), RPS4X(1), VASP(1) 20502607 35 32 34 13 21 3 3 3 5 0 0.307 1.000 1.000 515 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(6), CHUK(1), CREB1(1), DAXX(3), ELK1(2), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(2), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), MAPKAPK2(1), MAPKAPK3(1), MAX(2), MEF2A(2), MEF2D(1), NFKB1(1), NFKBIA(1), PAK1(1), RAF1(1), RIPK1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), SP1(1), STAT1(2), TGFBR1(2) 40909672 72 64 66 18 19 19 8 17 9 0 0.0587 1.000 1.000 516 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT1(2), AGPAT2(1), CHAT(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), GNPAT(1), GPD2(1), LCAT(1), LGALS13(1), PCYT1A(2), PCYT1B(1), PISD(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB2(3), PLCG1(6), PLCG2(3) 21394404 44 39 44 15 16 8 2 13 5 0 0.328 1.000 1.000 517 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1C(2), ACVRL1(1), AMHR2(1), BMP2(1), BMP4(1), BMP5(4), BMP6(1), BMPR2(1), CDKN2B(2), CHRD(1), CREBBP(4), CUL1(3), DCN(1), E2F4(1), EP300(1), GDF5(1), GDF6(1), GDF7(1), ID1(1), IFNG(2), INHBA(1), INHBE(1), LEFTY2(2), MAPK1(2), MAPK3(1), PITX2(3), PPP2R1B(1), RBL1(2), ROCK1(2), ROCK2(1), SMAD4(1), SMAD7(1), SMURF1(2), SP1(1), TFDP1(1), TGFBR1(2), TGFBR2(2), THBS1(2), THBS3(1), THBS4(2), ZFYVE16(1), ZFYVE9(1) 42205216 64 58 64 15 15 13 9 16 11 0 0.0668 1.000 1.000 518 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX15B(1), ALOX5(1), CBR1(2), CYP2B6(4), CYP2C19(2), CYP2C8(2), CYP2E1(1), CYP2U1(1), CYP4A11(4), CYP4F2(3), CYP4F3(2), GGT1(1), GPX1(1), GPX4(1), GPX5(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 16584477 39 34 39 14 19 5 1 11 3 0 0.346 1.000 1.000 519 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(5), ACACB(7), ACOT12(1), ACYP1(1), ALDH1A3(1), ALDH3A1(2), DLD(2), HAGH(1), LDHAL6A(1), LDHAL6B(1), ME1(1), ME2(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1) 19872097 34 34 34 12 15 5 1 11 2 0 0.455 1.000 1.000 520 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 BCL2(2), CABIN1(5), CALM1(1), CAMK4(1), CD3E(2), CD3G(1), CDKN1A(1), CEBPB(1), CREBBP(4), CSF2(2), CSNK2A1(1), CSNK2B(2), EGR2(2), EGR3(1), EP300(1), FCER1A(2), FOS(1), GATA4(2), GSK3B(1), IFNB1(1), IFNG(2), IL1B(1), IL3(1), IL6(1), KPNA5(1), MEF2A(2), MEF2D(1), MYF5(2), NFATC2(2), NFATC4(2), NFKB2(1), NFKBIE(2), NUP214(2), OPRD1(1), PAK1(1), PPP3CB(1), PTPRC(2), RPL13A(1), SFN(1), SP1(1), SP3(1), TRPV6(7), VAV1(4), VAV2(2), VAV3(1) 38766387 77 67 77 23 20 13 10 18 16 0 0.136 1.000 1.000 521 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BRAF(6), CD244(1), CSF2(2), FYN(1), GZMB(2), HLA-G(2), ICAM1(1), ICAM2(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), ITGB2(4), KIR2DL1(3), KIR3DL2(5), KLRC1(1), KLRC2(4), KLRD1(1), KLRK1(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MICB(1), NCR1(2), NFATC2(2), NFATC4(2), NRAS(1), PAK1(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PPP3CB(1), PRKCA(1), PRKCG(2), PTK2B(3), PTPN11(4), PTPN6(1), RAF1(1), SH2D1A(1), SH2D1B(2), SHC4(1), SOS1(3), TNFSF10(2), ULBP1(1), VAV1(4), VAV2(2), VAV3(1), ZAP70(3) 48441960 187 129 171 47 36 30 28 52 41 0 0.0270 1.000 1.000 522 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACOX2(1), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), APOA5(1), AQP7(1), CD36(1), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(4), CYP7A1(1), CYP8B1(2), EHHADH(1), FABP1(1), FABP6(1), GK(2), GK2(1), ME1(1), MMP1(2), OLR1(1), PCK1(3), PLTP(1), PPARA(1), PPARG(1), RXRA(3), SLC27A1(1), SLC27A2(6), SLC27A6(4), SORBS1(2), UBC(3) 27848836 55 49 55 18 24 7 5 13 6 0 0.259 1.000 1.000 523 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(1), CBL(1), CBLB(1), CCND2(2), CCND3(1), CREBBP(4), CSF2(2), CSF2RA(1), CSF2RB(4), CSF3R(1), EP300(1), EPO(1), GH1(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), IFNW1(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA2(1), IL15RA(1), IL20(1), IL21R(2), IL22(2), IL26(2), IL28B(1), IL28RA(1), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), IRF9(1), JAK1(2), JAK2(1), JAK3(2), LEPR(1), MPL(3), OSM(1), OSMR(2), PIAS1(1), PIAS3(1), PIAS4(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIM1(1), PTPN11(4), PTPN6(1), SOCS1(1), SOCS4(1), SOS1(3), SPRY3(2), STAM2(1), STAT1(2), STAT2(1), STAT3(1), STAT4(2), STAT6(1), TPO(4), TYK2(3) 61847416 193 138 181 45 51 33 22 47 40 0 0.00821 1.000 1.000 524 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AANAT(1), ABP1(4), ACMSD(1), ALDH1A3(1), ALDH3A1(2), AOC2(1), AOX1(4), ASMT(1), CARM1(1), CYP1A2(2), CYP1B1(1), DDC(3), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1), KYNU(1), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), NFX1(1), OGDHL(3), PRMT8(1), TPH1(2), WARS(1) 25781585 41 38 40 14 21 4 1 11 4 0 0.362 1.000 1.000 525 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 APH1A(2), CREBBP(4), CTBP2(3), DLL1(1), DTX2(1), DTX3L(1), DTX4(2), DVL1(1), DVL2(2), DVL3(1), EP300(1), HDAC2(3), HES1(1), JAG1(3), JAG2(4), LFNG(1), MAML1(2), NCOR2(2), NCSTN(1), NOTCH2(5), NOTCH3(1), NOTCH4(2), PSEN1(1), RBPJL(3) 29877976 48 43 48 16 10 10 9 8 11 0 0.411 1.000 1.000 526 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP4A(1), ATP5A1(1), ATP5B(1), ATP5I(1), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), COX10(2), COX7C(1), LHPP(1), NDUFA10(1), NDUFA12(1), NDUFA4(1), NDUFA9(1), NDUFB1(1), NDUFS2(1), PPA2(1), UQCRC1(1), UQCRQ(1) 23808656 29 27 29 10 10 5 4 8 2 0 0.468 1.000 1.000 527 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTN1(2), ACTN3(1), AKT1(1), ARHGAP5(3), BCL2(2), BIRC2(1), BIRC3(1), BRAF(6), CAV3(1), CCND2(2), CCND3(1), COL11A1(2), COL11A2(7), COL1A1(1), COL1A2(11), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), CRKL(1), DOCK1(2), EGF(3), EGFR(92), ELK1(2), ERBB2(1), FIGF(2), FLNA(5), FLNB(2), FLNC(3), FLT1(5), FN1(3), FYN(1), GSK3B(1), HGF(1), IGF1(2), IGF1R(3), ITGA1(2), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), KDR(8), LAMA1(8), LAMA2(7), LAMA3(3), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), MAP2K1(1), MAPK1(2), MAPK3(1), MET(3), MYLK(2), PAK1(1), PAK4(2), PAK7(1), PARVG(1), PDGFD(2), PDGFRA(14), PDGFRB(3), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP5K1C(1), PPP1CC(1), PRKCA(1), PRKCG(2), PTEN(90), PXN(1), RAF1(1), RELN(13), ROCK1(2), ROCK2(1), SHC4(1), SOS1(3), SRC(2), THBS1(2), THBS3(1), THBS4(2), TLN2(2), TNC(1), TNN(1), TNXB(3), VASP(1), VAV1(4), VAV2(2), VAV3(1), VEGFA(2), VEGFB(1), VEGFC(1), VWF(7), ZYX(2) 158792751 575 234 491 133 124 142 58 138 113 0 6.79e-08 1.000 1.000 528 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1C(2), AKT1(1), BRAF(6), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1F(1), CACNA1H(4), CACNA1I(3), CACNA1S(7), CACNA2D1(7), CACNA2D2(2), CACNA2D3(2), CACNA2D4(1), CACNB3(2), CACNG2(1), CACNG3(2), CHUK(1), CRKL(1), DAXX(3), DDIT3(1), DUSP10(1), DUSP5(1), EGF(3), EGFR(92), ELK1(2), FGF13(1), FGF14(2), FGF18(2), FGF7(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(2), FLNA(5), FLNB(2), FLNC(3), FOS(1), GADD45B(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(2), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3), MAPKAPK2(1), MAPKAPK3(1), MAX(2), NF1(30), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(1), PAK1(1), PDGFRA(14), PDGFRB(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PPM1B(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PTPRR(3), RAF1(1), RAPGEF2(1), RASGRF1(3), RASGRF2(2), RASGRP1(1), RASGRP2(1), RASGRP4(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), RPS6KA6(2), SOS1(3), SRF(1), STK3(1), TAOK1(1), TAOK2(1), TAOK3(2), TGFBR1(2), TGFBR2(2), TNFRSF1A(1), TP53(96) 122791333 442 217 346 90 115 106 40 107 69 5 7.04e-10 1.000 1.000 529 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(1), ACTN1(2), ACTN3(1), APC(1), APC2(3), ARHGEF12(1), ARHGEF6(2), ARHGEF7(2), ARPC2(1), BDKRB1(1), BRAF(6), CFL2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CRKL(1), CSK(1), DIAPH2(3), DIAPH3(2), DOCK1(2), EGF(3), EGFR(92), EZR(4), F2(1), FGD3(2), FGF13(1), FGF14(2), FGF18(2), FGF7(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(2), FN1(3), GSN(1), IQGAP2(1), IQGAP3(3), ITGA1(2), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAD(3), ITGAE(1), ITGAM(5), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(4), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MSN(1), MYH10(1), MYH14(3), MYH9(3), MYLK(2), NCKAP1(1), NCKAP1L(1), NRAS(1), PAK1(1), PAK4(2), PAK7(1), PDGFRA(14), PDGFRB(3), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PPP1CC(1), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(2), ROCK2(1), SOS1(3), SSH1(2), SSH2(1), TIAM2(5), VAV1(4), VAV2(2), VAV3(1), WAS(1) 118360710 364 206 297 86 86 85 35 103 55 0 9.67e-05 1.000 1.000 530 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY7(1), ADCY8(2), ADCY9(4), AGTR1(1), ATP2A1(2), ATP2A3(2), ATP2B2(4), ATP2B3(2), AVPR1A(2), AVPR1B(1), BDKRB1(1), BST1(1), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1F(1), CACNA1H(4), CACNA1I(3), CACNA1S(7), CALM1(1), CAMK2A(1), CAMK4(1), CCKAR(1), CD38(1), CHRM1(1), CHRM2(3), CHRM3(1), CYSLTR2(1), DRD1(1), EGFR(92), ERBB2(1), GRIN2A(10), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(2), GRPR(1), HRH2(3), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), ITPR1(5), ITPR2(3), ITPR3(5), LHCGR(2), MYLK(2), NOS1(5), NOS3(3), NTSR1(3), P2RX2(1), P2RX5(1), PDE1A(2), PDE1C(4), PDGFRA(14), PDGFRB(3), PHKA1(2), PHKG1(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), PPID(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PTAFR(1), PTGFR(1), PTK2B(3), RYR1(4), RYR2(30), RYR3(17), TACR3(4), TNNC2(1), TRPC1(1), VDAC1(2), VDAC2(1) 115554380 353 194 303 94 141 79 24 81 28 0 3.75e-06 1.000 1.000 531 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(1), ADRA2B(1), ADRA2C(2), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), C5AR1(3), CALCR(8), CALCRL(1), CCKAR(1), CGA(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CRHR2(2), CTSG(3), CYSLTR2(1), DRD1(1), DRD2(1), DRD3(1), DRD5(7), F2(1), F2RL3(2), FSHR(1), GABBR2(1), GABRA1(6), GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), GABRA6(11), GABRB1(1), GABRB2(6), GABRB3(6), GABRD(1), GABRE(2), GABRG1(2), GABRG2(4), GABRP(1), GABRQ(1), GABRR2(1), GALR1(1), GH1(1), GHRHR(1), GHSR(2), GLP1R(1), GLP2R(2), GLRA1(1), GLRA2(1), GLRA3(1), GNRHR(1), GPR156(1), GPR35(1), GPR50(1), GPR83(2), GRIA1(2), GRIA3(3), GRID1(1), GRID2(2), GRIK1(2), GRIK2(1), GRIK3(4), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), GRIN3A(2), GRIN3B(1), GRM1(3), GRM3(9), GRM4(2), GRM5(2), GRM6(3), GRM7(2), GRM8(5), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(3), HRH3(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), LEPR(1), LHCGR(2), MC2R(2), MC3R(4), MC4R(3), MC5R(2), MCHR1(1), MCHR2(2), MTNR1B(1), NMBR(1), NMUR1(1), NMUR2(4), NPBWR1(1), NPBWR2(2), NPFFR2(2), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), P2RX2(1), P2RX5(1), P2RY10(1), P2RY2(1), P2RY4(1), P2RY8(3), PARD3(1), PPYR1(1), PRLHR(1), PRSS1(1), PTAFR(1), PTGER4(1), PTGFR(1), PTH2R(1), RXFP1(3), RXFP2(1), SSTR2(1), SSTR3(1), SSTR4(4), SSTR5(1), TAAR1(1), TACR3(4), THRA(1), TRPV1(2), TSHR(1), UTS2R(1), VIPR2(1) 94274206 288 170 286 117 163 35 23 54 13 0 0.0899 1.000 1.000 532 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 AMHR2(1), BMP2(1), BMPR2(1), CCL13(1), CCL14(1), CCL15(1), CCL19(1), CCL2(1), CCL24(2), CCL3(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CD70(1), CSF1R(1), CSF2(2), CSF2RA(1), CSF2RB(4), CSF3R(1), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL6(1), EDA(1), EDAR(1), EGF(3), EGFR(92), EPO(1), FLT1(5), FLT3(4), FLT4(2), GDF5(1), GH1(1), HGF(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), IFNW1(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL15RA(1), IL17RA(2), IL17RB(1), IL18R1(2), IL18RAP(6), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL20(1), IL21R(2), IL22(2), IL26(2), IL28B(1), IL28RA(1), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), INHBA(1), INHBE(1), KDR(8), KIT(3), KITLG(1), LEPR(1), MET(3), MPL(3), OSM(1), OSMR(2), PDGFRA(14), PDGFRB(3), PPBP(1), RELT(1), TGFBR1(2), TGFBR2(2), TNFRSF11A(2), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF25(1), TNFRSF4(2), TNFRSF8(2), TNFRSF9(1), TNFSF10(2), TNFSF11(1), TNFSF14(2), TNFSF18(1), TNFSF8(1), TNFSF9(3), TPO(4), VEGFA(2), VEGFB(1), VEGFC(1), XCL1(2), XCR1(1) 75701906 283 167 231 87 81 73 16 86 27 0 0.00851 1.000 1.000 533 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 COL11A1(2), COL11A2(7), COL17A1(3), COL1A1(1), COL1A2(11), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), DES(3), DSC1(3), DSC2(3), DSC3(3), DSG1(2), DSG3(9), DSG4(5), FN1(3), GJA10(1), GJA9(1), GJB3(2), GJB4(1), GJC1(1), GJC3(1), GJD2(3), ITGB4(3), KRT1(1), KRT12(2), KRT13(3), KRT14(1), KRT15(2), KRT16(2), KRT17(1), KRT18(2), KRT2(1), KRT20(2), KRT23(1), KRT24(1), KRT25(3), KRT28(1), KRT31(1), KRT32(1), KRT33A(2), KRT33B(1), KRT34(2), KRT35(1), KRT36(1), KRT37(4), KRT38(1), KRT39(2), KRT4(1), KRT40(2), KRT6B(1), KRT74(1), KRT75(2), KRT76(1), KRT79(3), KRT8(1), KRT81(1), KRT84(2), KRT86(1), KRT9(3), LAMA1(8), LAMA2(7), LAMA3(3), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), LMNB2(1), NES(1), RELN(13), THBS1(2), THBS3(1), THBS4(2), TNC(1), TNN(1), TNXB(3), VWF(7) 106427029 257 166 256 114 110 50 23 48 26 0 0.602 1.000 1.000 534 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(2), CD36(1), CD44(3), COL11A1(2), COL11A2(7), COL1A1(1), COL1A2(11), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), DAG1(2), FN1(3), FNDC1(3), FNDC4(1), HSPG2(8), ITGA1(2), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), LAMA1(8), LAMA2(7), LAMA3(3), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), RELN(13), SDC1(1), SDC2(1), SDC4(1), SV2B(2), SV2C(2), THBS1(2), THBS3(1), THBS4(2), TNC(1), TNN(1), TNXB(3), VWF(7) 96267516 208 143 208 83 76 47 21 38 26 0 0.277 1.000 1.000 535 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(5), ACACB(7), AKT1(1), BRAF(6), CALM1(1), CBL(1), CBLB(1), CRKL(1), ELK1(2), EXOC7(2), FBP1(2), FBP2(1), FLOT1(1), FOXO1(1), G6PC(1), GSK3B(1), IKBKB(1), INPP5D(3), INSR(2), IRS1(4), IRS4(2), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), PCK1(3), PDE3A(3), PDE3B(3), PFKL(1), PHKA1(2), PHKG1(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PKLR(1), PPP1CC(1), PPP1R3A(7), PRKAG2(1), PRKAG3(1), PRKAR1B(1), PRKAR2B(1), PRKX(1), PTPRF(5), PYGB(2), PYGL(1), PYGM(1), RAF1(1), RHOQ(1), SH2B2(1), SHC4(1), SOCS1(1), SOCS4(1), SORBS1(2), SOS1(3), SREBF1(1), TRIP10(1), TSC2(3) 68594435 189 136 173 41 47 32 21 54 35 0 0.00377 1.000 1.000 536 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(2), ACTN3(1), ARHGAP5(3), CDH5(3), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CTNNA1(2), CTNNA2(2), CTNNA3(2), CYBB(1), EZR(4), F11R(1), ICAM1(1), ITGA4(3), ITGAM(5), ITGB1(1), ITGB2(4), MAPK13(1), MLLT4(3), MMP9(2), MSN(1), NCF1(1), NCF2(2), NOX3(4), OCLN(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PRKCA(1), PRKCG(2), PTK2B(3), PTPN11(4), PXN(1), RAPGEF3(1), RAPGEF4(1), RASSF5(1), ROCK1(2), ROCK2(1), SIPA1(1), TXK(1), VASP(1), VAV1(4), VAV2(2), VAV3(1), VCAM1(1) 53090327 180 134 168 51 53 24 21 44 38 0 0.0976 1.000 1.000 537 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), ATP1A4(2), ATP2A3(2), ATP2B2(4), ATP2B3(2), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1S(7), CACNB3(2), CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), CASQ2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), GJB3(2), GJB4(1), GNAO1(1), GNB1(1), GNB4(1), GNG2(1), GNG5(1), ITPR1(5), ITPR2(3), ITPR3(5), KCNB1(2), KCNJ3(1), KCNJ5(2), MIB1(4), NME7(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), RGS1(1), RGS14(1), RGS3(2), RGS4(2), RGS6(1), RGS9(3), RYR1(4), RYR2(30), RYR3(17), SFN(1), YWHAH(1) 80603643 184 133 182 57 84 30 17 36 17 0 0.0145 1.000 1.000 538 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(2), ABLIM3(4), ARHGEF12(1), CFL2(1), DCC(6), DPYSL5(2), EFNA3(1), EFNA5(2), EFNB1(1), EFNB2(1), EFNB3(1), EPHA1(4), EPHA3(3), EPHA4(1), EPHA5(4), EPHA6(4), EPHA7(3), EPHA8(4), EPHB1(2), EPHB2(3), EPHB4(2), EPHB6(4), FES(1), FYN(1), GSK3B(1), ITGB1(1), KRAS(2), L1CAM(5), LRRC4C(2), MAPK1(2), MAPK3(1), MET(3), NFATC2(2), NFATC4(2), NGEF(1), NRAS(1), NRP1(1), NTN1(2), NTN4(3), NTNG1(1), PAK1(1), PAK4(2), PAK7(1), PLXNA1(1), PLXNA2(3), PLXNA3(1), PLXNB3(1), PLXNC1(1), PPP3CB(1), RGS3(2), ROBO1(3), ROBO2(2), ROCK1(2), ROCK2(1), SEMA3C(11), SEMA3E(8), SEMA4A(1), SEMA4C(1), SEMA4D(1), SEMA4F(2), SEMA5B(1), SEMA6B(1), SEMA6D(1), SEMA7A(1), SLIT2(3), SLIT3(9), SRGAP1(2), SRGAP2(2), SRGAP3(1), UNC5A(1), UNC5C(3), UNC5D(1) 84448082 160 124 158 56 43 29 21 47 20 0 0.312 1.000 1.000 539 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(1), ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), ATP2A3(2), CACNB3(2), CALCA(1), CALM1(1), CAMK2A(1), CORIN(2), DGKZ(1), FOS(1), GNB1(1), GNB4(1), GNG2(1), GNG5(1), GUCY1A3(1), IL1B(1), IL6(1), ITPR1(5), ITPR2(3), ITPR3(5), MIB1(4), NFKB1(1), NOS1(5), NOS3(3), PDE4B(1), PLCD1(3), PLCG1(6), PLCG2(3), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCQ(2), PRKD1(1), RAMP3(1), RGS1(1), RGS14(1), RGS3(2), RGS4(2), RGS6(1), RGS9(3), RYR1(4), RYR2(30), RYR3(17), SFN(1), SP1(1), TNXB(3), YWHAH(1) 74334597 161 122 160 49 73 23 13 34 18 0 0.0166 1.000 1.000 540 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 CADM1(1), CADM3(1), CD2(1), CD22(6), CD276(1), CD28(1), CD4(1), CD58(1), CD6(2), CD86(2), CD8A(1), CDH15(2), CDH4(2), CDH5(3), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CNTN1(1), CNTN2(2), CNTNAP1(1), CNTNAP2(13), F11R(1), GLG1(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), HLA-G(2), ICAM1(1), ICAM2(1), ICOSLG(2), ITGA4(3), ITGA8(1), ITGA9(2), ITGAM(5), ITGAV(1), ITGB1(1), ITGB2(4), ITGB7(3), ITGB8(1), L1CAM(5), MAG(3), MPZL1(2), NCAM1(2), NEGR1(2), NEO1(1), NFASC(1), NLGN1(1), NLGN3(1), NRCAM(2), NRXN1(5), NRXN2(1), NRXN3(3), OCLN(1), PDCD1(1), PTPRC(2), PTPRF(5), PTPRM(3), PVR(1), PVRL1(2), PVRL2(1), SDC1(1), SDC2(1), SDC4(1), SELE(2), SELP(2), SELPLG(2), SIGLEC1(2), VCAM1(1), VCAN(3) 63057614 145 111 145 65 71 16 14 31 13 0 0.617 1.000 1.000 541 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADRA2C(2), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), CCBP2(1), CCKAR(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CHML(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CX3CR1(2), DRD1(1), DRD2(1), DRD3(1), DRD5(7), F2RL3(2), FSHR(1), GALR1(1), GALT(1), GHSR(2), GPR17(1), GPR174(1), GPR27(1), GPR35(1), GPR37(2), GPR4(2), GPR50(1), GPR6(1), GPR77(1), GPR83(2), GPR85(2), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(3), HRH3(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), LHCGR(2), MC3R(4), MC4R(3), MC5R(2), MTNR1B(1), NMBR(1), NMUR1(1), NMUR2(4), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), OR1C1(1), OR1F1(1), OR2H1(3), OR7A5(1), OR7C1(1), P2RY10(1), P2RY2(1), PPYR1(1), PTAFR(1), PTGER4(1), PTGFR(1), RGR(1), SSTR2(1), SSTR3(1), SSTR4(4), SUCNR1(1) 51645770 139 108 138 60 91 17 7 19 5 0 0.139 1.000 1.000 542 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(1), ACTN3(1), DES(3), DMD(11), FAM48A(2), MYBPC3(1), MYH3(2), MYH6(2), MYH7(2), MYH8(7), MYL3(1), MYOM1(2), NEB(6), TMOD1(1), TNNC2(1), TNNT1(3), TNNT2(1), TPM3(1), TTN(94) 58581110 142 102 140 34 60 16 12 40 14 0 0.0225 1.000 1.000 543 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), AK1(1), AK5(1), AK7(5), ALLC(4), AMPD1(3), AMPD2(1), AMPD3(1), CANT1(1), DCK(1), ENPP1(1), FHIT(1), GDA(1), GMPR2(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IMPDH1(2), NME7(2), NPR1(1), NT5E(2), NUDT2(1), PDE10A(1), PDE11A(2), PDE1A(2), PDE1C(4), PDE2A(1), PDE3B(3), PDE4A(2), PDE4B(1), PDE8A(1), PDE8B(1), PFAS(1), PKLR(1), PNPT1(1), POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1), PRIM1(1), PRIM2(1), PRPS1L1(2), PRPS2(2), RRM2(1), XDH(3) 69759151 104 85 103 29 42 22 10 20 10 0 0.0343 1.000 1.000 544 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(2), CD19(1), CD1B(1), CD1D(4), CD1E(2), CD2(1), CD22(6), CD33(5), CD36(1), CD37(1), CD38(1), CD3E(2), CD3G(1), CD4(1), CD44(3), CD5(2), CD55(1), CD59(1), CD7(2), CD8A(1), CR2(4), CSF1R(1), CSF2(2), CSF2RA(1), CSF3R(1), DNTT(2), EPO(1), FCER2(1), FLT3(4), GYPA(1), HLA-DRA(1), IL1A(1), IL1B(1), IL1R1(2), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), ITGA1(2), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGAM(5), ITGB3(1), KIT(3), KITLG(1), MME(1), THPO(1), TPO(4) 34810141 102 83 101 36 49 12 6 19 16 0 0.223 1.000 1.000 545 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(1), AMY2B(3), ASCC3(4), ATP13A2(2), DDX18(1), DDX41(3), DDX56(1), DHX58(1), ENPP1(1), EP400(6), G6PC(1), GAA(1), GBA(1), HK2(2), HK3(2), MGAM(6), MOV10L1(4), PGM1(1), PYGB(2), PYGL(1), PYGM(1), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SI(2), SMARCA2(3), SMARCA5(1), TREH(1), UGT1A1(7), UGT2A1(4), UGT2A3(6), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B28(6), UGT2B4(5), UGT2B7(2), UXS1(2) 52774698 97 81 96 31 36 13 12 27 9 0 0.287 1.000 1.000 546 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(1), ABCA10(4), ABCA12(1), ABCA13(5), ABCA3(1), ABCA4(4), ABCA5(3), ABCA6(3), ABCA7(2), ABCA9(3), ABCB1(10), ABCB11(2), ABCB4(6), ABCB5(3), ABCB6(1), ABCB7(1), ABCB8(1), ABCB9(2), ABCC1(1), ABCC10(2), ABCC11(1), ABCC3(1), ABCC4(4), ABCC5(3), ABCC6(1), ABCC8(1), ABCC9(14), ABCD1(1), ABCD2(4), ABCD3(1), ABCG1(2), ABCG2(2), ABCG4(1), ABCG5(1), ABCG8(1), CFTR(2), TAP1(1), TAP2(4) 50675981 101 81 100 33 37 14 12 28 10 0 0.182 1.000 1.000 547 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), CAPN1(2), CAPN11(2), CAPN6(2), CAPNS1(1), CAV3(1), CSK(1), DOCK1(2), FYN(1), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAD(3), ITGAE(1), ITGAM(5), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(4), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), MAP2K1(1), MAP2K3(3), MAPK7(1), PAK1(1), PAK4(2), PIK3R2(3), PXN(1), ROCK1(2), ROCK2(1), SDCCAG8(2), SORBS1(2), SOS1(3), SRC(2), TNS1(3), VASP(1), VAV2(2), VAV3(1), ZYX(2) 57336327 91 79 91 35 36 15 8 23 9 0 0.396 1.000 1.000 548 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(6), CACNA1A(1), GNAO1(1), GRIA1(2), GRIA3(3), GRID2(2), GRM1(3), GRM5(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IGF1(2), IGF1R(3), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), LYN(2), MAP2K1(1), MAPK1(2), MAPK3(1), NOS1(5), NOS3(3), NPR1(1), NRAS(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP2R1B(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(5), RAF1(1), RYR1(4) 47197645 87 75 82 39 36 17 5 20 9 0 0.685 1.000 1.000 549 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(3), ADCY8(2), BRAF(6), CACNA1C(5), CALM1(1), CAMK2A(1), CAMK4(1), CREBBP(4), EP300(1), GRIA1(2), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(2), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP1CC(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), RAPGEF3(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2) 42691091 86 70 81 28 39 15 7 19 6 0 0.137 1.000 1.000 550 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), AK1(1), AK5(1), ALLC(4), AMPD1(3), AMPD2(1), AMPD3(1), ATP5A1(1), ATP5B(1), ATP5I(1), CANT1(1), DCK(1), ENPP1(1), FHIT(1), GDA(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IMPDH1(2), NPR1(1), NT5E(2), NUDT2(1), PDE1A(2), PDE4A(2), PDE4B(1), PDE6B(2), PDE8A(1), PFAS(1), PKLR(1), POLD1(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(2), PRPS1L1(2), PRPS2(2), RRM2(1) 54769909 77 65 77 25 32 13 5 17 10 0 0.254 1.000 1.000 551 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 CARM1(1), DOT1L(1), EHMT2(2), EZH2(3), HCFC1(1), JMJD4(1), JMJD6(1), KDM6A(3), MEN1(3), MLL(3), MLL2(10), MLL3(10), MLL5(1), NSD1(1), OGT(1), PPP1CC(1), PRDM7(1), PRDM9(10), PRMT8(1), RBBP5(2), SETD1A(3), SETD2(3), SETDB1(1), SMYD3(2), SUV39H2(1), SUV420H1(1), SUZ12(1) 51005383 69 60 69 23 13 13 7 27 9 0 0.603 1.000 1.000 552 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG1(1), ALG10B(1), ALG3(2), B3GNT7(1), B4GALT2(1), CHST1(1), CHST13(1), CHST2(2), CHST4(1), CHST6(2), CHSY1(2), EXT2(1), EXTL1(1), FUT8(1), GALNT1(1), GALNT11(1), GALNT13(2), GALNT14(3), GALNT2(1), GALNT4(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT9(2), GALNTL1(1), GALNTL4(1), GCNT1(2), GCNT3(1), GCNT4(1), HS3ST1(2), HS3ST3A1(2), MAN1A1(1), MGAT2(1), MGAT5(1), MGAT5B(1), NDST3(1), NDST4(6), OGT(1), ST3GAL1(1), ST6GAL1(1), UST(1), WBSCR17(6), XYLT1(1), XYLT2(2) 46948191 67 59 67 25 30 10 9 10 8 0 0.333 1.000 1.000 553 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(7), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), AKT1(1), CAMKK1(1), CD36(1), CHUK(1), CPT1A(1), CPT1C(1), CPT2(1), G6PC(1), IKBKB(1), IRS1(4), IRS4(2), JAK1(2), JAK2(1), JAK3(2), LEPR(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PCK1(3), PPARA(1), PRKAG2(1), PRKAG3(1), PRKCQ(2), PTPN11(4), RXRA(3), SLC2A1(2), STAT3(1), TNFRSF1A(1), TNFRSF1B(1), TYK2(3) 35384183 60 57 60 22 22 10 3 16 9 0 0.410 1.000 1.000 554 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 CCR3(1), CCR5(1), CELSR1(4), CELSR2(2), CELSR3(5), CHRM2(3), CHRM3(1), EMR2(1), EMR3(1), FSHR(1), GHRHR(1), GNRHR(1), GPR116(6), GPR132(2), GPR133(3), GPR143(2), GPR17(1), GPR61(1), GPR77(1), GRM1(3), GRPR(1), LGR6(1), LPHN2(1), LPHN3(2), NTSR1(3), OR2M4(2), OR8G2(1), PTGFR(1), SMO(1), SSTR2(1), TSHR(1) 28459266 56 49 56 37 31 4 5 14 2 0 0.978 1.000 1.000 555 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(1), ADCY6(2), ADCY8(2), CACNA1A(1), CACNA1B(6), GNAT3(4), GNB1(1), GRM4(2), ITPR3(5), KCNB1(2), PDE1A(2), PLCB2(3), PRKX(1), SCNN1A(1), SCNN1B(3), SCNN1G(4), TAS1R1(2), TAS1R2(2), TAS2R1(2), TAS2R10(1), TAS2R16(1), TAS2R39(1), TAS2R41(2), TAS2R5(1), TAS2R60(1), TRPM5(1) 24513275 54 47 53 24 27 6 6 7 8 0 0.640 1.000 1.000 556 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), COL2A1(2), CPSF1(4), CSTF1(1), CSTF2(1), DDIT3(1), DDX20(1), DHX38(1), DHX8(1), DICER1(5), FUS(1), LOC440563(2), NCBP2(1), NONO(2), NUDT21(1), NXF1(1), PAPOLA(2), PHF5A(1), POLR2A(2), PRPF4(1), PRPF4B(1), PRPF8(2), PTBP1(1), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(1), SF3B2(1), SF3B4(1), SNRPB(1), SRPK1(2), SRPK2(1), SRRM1(1) 45065784 48 46 48 12 16 7 8 7 10 0 0.196 1.000 1.000 557 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACPT(2), ALPI(1), ALPP(2), ALPPL2(4), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(4), CYP2C19(2), CYP2C8(2), CYP2D6(2), CYP2E1(1), CYP2F1(1), CYP3A4(2), CYP3A7(5), CYP4B1(4), CYP4F8(3), PON1(2) 12436380 42 39 42 16 25 3 5 7 2 0 0.387 1.000 1.000 558 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CANX(1), CD4(1), CD8A(1), CIITA(3), CREB1(1), CTSB(1), CTSS(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), HLA-G(2), HSP90AB1(2), IFNA10(2), IFNA21(1), KIR2DL1(3), KIR3DL2(5), KLRC1(1), KLRC2(4), KLRD1(1), NFYB(1), PDIA3(1), RFX5(1), TAP1(1), TAP2(4) 19797348 44 39 44 21 17 8 5 9 5 0 0.798 1.000 1.000 559 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GAPDHS(1), HK2(2), HK3(2), LDHAL6A(1), LDHAL6B(1), PDHA1(1), PDHA2(3), PFKL(1), PGAM4(1), PGK1(1), PGK2(1), PGM1(1), PKLR(1) 24734126 41 38 41 17 17 6 2 13 3 0 0.561 1.000 1.000 560 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(2), ALPPL2(4), ASCC3(4), ATP13A2(2), DDX18(1), DDX41(3), DDX56(1), DHX58(1), EP400(6), MOV10L1(4), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SMARCA2(3), SMARCA5(1) 26755541 39 37 39 13 14 8 4 10 3 0 0.383 1.000 1.000 561 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), HK2(2), HK3(2), PDHA1(1), PDHA2(3), PGK1(1), PGM1(1), PKLR(1) 20727978 38 35 38 16 18 7 1 10 2 0 0.544 1.000 1.000 562 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), HK2(2), HK3(2), PDHA1(1), PDHA2(3), PGK1(1), PGM1(1), PKLR(1) 20727978 38 35 38 16 18 7 1 10 2 0 0.544 1.000 1.000 563 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(3), CANT1(1), CDA(2), DCK(1), DPYD(2), DPYS(1), DTYMK(1), NME7(2), NT5E(2), NUDT2(1), PNPT1(1), POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1), PRIM1(1), PRIM2(1), RRM2(1), TXNRD1(1), TXNRD2(2), UCK1(1), UPP1(2), UPP2(1) 34619747 42 35 42 12 9 12 8 11 2 0 0.177 1.000 1.000 564 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(1), AMY2B(3), ENPP1(1), G6PC(1), GAA(1), HK2(2), HK3(2), MGAM(6), PGM1(1), PYGB(2), PYGL(1), PYGM(1), SI(2), UGT1A1(7), UGT2B15(1), UGT2B4(5), UXS1(2) 24331675 39 34 39 17 20 5 2 8 4 0 0.690 1.000 1.000 565 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GAPDHS(1), GOT2(1), HK2(2), HK3(2), LDHAL6B(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PFKL(1), PGK1(1), PGK2(1), PKLR(1), TNFAIP1(1) 18024623 31 31 31 16 13 5 1 10 2 0 0.781 1.000 1.000 566 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALNT1(2), B3GALT5(1), B3GNT3(2), B4GALNT1(1), B4GALT2(1), B4GALT6(1), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GCNT2(1), PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1), ST3GAL1(1), ST3GAL6(2), ST6GALNAC3(1), ST6GALNAC4(1), ST8SIA1(1) 20709753 30 30 30 12 10 3 3 10 4 0 0.725 1.000 1.000 567 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 GALNT1(1), GALNT11(1), GALNT13(2), GALNT14(3), GALNT2(1), GALNT4(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT9(2), GALNTL1(1), GALNTL4(1), GCNT1(2), GCNT3(1), GCNT4(1), OGT(1), ST3GAL1(1), WBSCR17(6) 13697206 29 27 29 10 13 4 2 5 5 0 0.510 1.000 1.000 568 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(3), CANT1(1), CDA(2), DCK(1), DPYD(2), DPYS(1), DTYMK(1), NT5E(2), NUDT2(1), POLD1(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(2), RRM2(1), TXNRD1(1), UCK1(1), UPP1(2) 24465057 30 27 30 12 3 6 6 12 3 0 0.748 1.000 1.000 569 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(2), ARSE(3), CYP11B1(1), CYP11B2(2), HSD11B1(2), HSD17B3(1), SRD5A1(1), SRD5A2(1), STS(2), UGT1A1(7), UGT2B15(1), UGT2B4(5) 11637727 28 26 28 12 10 8 1 6 3 0 0.517 1.000 1.000 570 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2H1(2), GTF2H4(1), GTF2IRD1(1), TAF1(4), TAF1L(9), TAF2(3), TAF4(2), TAF6(1), TAF7(1), TAF7L(4), TBPL2(1) 15331345 29 26 29 10 8 3 3 11 4 0 0.717 1.000 1.000 571 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(4), GRM1(3), GRM3(9), GRM4(2), GRM5(2), GRM7(2), GRM8(5) 8891338 27 25 26 22 20 0 1 6 0 0 0.978 1.000 1.000 572 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(3), ASAH1(1), B4GALT6(1), ENPP7(4), GAL3ST1(2), GBA(1), LCT(3), NEU1(1), NEU2(3), NEU4(2), SGMS2(1), SGPP2(2), UGT8(1) 15338876 25 24 25 13 11 6 2 5 1 0 0.672 1.000 1.000 573 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(1), ACADS(3), ACSM1(1), AKR1B10(1), ALDH1A3(1), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), HSD17B4(1), OXCT2(1), PDHA1(1), PDHA2(3), PLA1A(1), PPME1(1) 17297037 24 24 24 10 9 5 2 4 4 0 0.597 1.000 1.000 574 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(6), C5(1), C6(1), ICAM1(1), IL1A(1), IL6(1), ITGA4(3), ITGB1(1), ITGB2(4), SELP(2), SELPLG(2), VCAM1(1) 10566078 24 23 24 14 6 3 3 7 5 0 0.899 1.000 1.000 575 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(2), ARHGAP5(3), ARHGAP6(2), ARHGEF11(2), ARHGEF5(2), ARPC2(1), GSN(1), MYLK(2), OPHN1(2), PIP5K1B(2), PPP1R12B(1), ROCK1(2), SRC(2) 19525115 24 23 23 11 5 5 3 7 4 0 0.792 1.000 1.000 576 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT2(1), FBP2(1), G6PC(1), GAA(1), GALE(2), GALK1(1), GALK2(1), GALT(1), HK2(2), HK3(2), LCT(3), MGAM(6), PGM1(1) 13915704 23 22 23 10 11 4 2 4 2 0 0.558 1.000 1.000 577 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(1), AKR1B10(1), ALDH1A3(1), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2), HADHA(1), HSD17B4(1), NSD1(1), OGDHL(3), PIPOX(1), SETD1A(3), SETDB1(1), SUV39H2(1) 24788030 22 22 22 14 9 5 0 6 2 0 0.942 1.000 1.000 578 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(1), ITGA4(3), ITGAM(5), ITGB1(1), ITGB2(4), SELE(2), SELP(2) 6811851 21 20 21 15 9 1 3 5 3 0 0.921 1.000 1.000 579 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(3), FYN(1), LRP8(1), RELN(13) 5950091 18 18 18 10 6 2 4 2 4 0 0.729 1.000 1.000 580 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(1), ALDOB(1), FBP1(2), FBP2(1), HK2(2), HK3(2), LHPP(1), MTMR1(2), PFKFB1(2), PFKFB4(1), PFKL(1), PMM1(1) 15893761 17 16 17 12 11 1 2 2 1 0 0.916 1.000 1.000 581 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(1), AGPAT6(1), ENPP2(4), ENPP6(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLD1(1) 9880343 16 16 16 7 9 2 0 5 0 0 0.682 1.000 1.000 582 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSE(3), ASAH1(1), GAL3ST1(2), GBA(1), LCT(3), NEU1(1), NEU2(3), NEU4(2) 10365168 16 15 16 11 7 3 1 4 1 0 0.903 1.000 1.000 583 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), FBP1(2), FBP2(1), G6PD(1), PFKL(1), PGLS(1), PGM1(1), PRPS1L1(2), PRPS2(2), RPE(1), TKTL1(1), TKTL2(1) 10352264 15 15 15 9 8 2 2 3 0 0 0.815 1.000 1.000 584 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(1), ITGA4(3), ITGB1(1), ITGB2(4), SELE(2) 5171941 14 14 14 11 5 1 2 3 3 0 0.928 1.000 1.000 585 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(1), ITGAM(5), ITGB2(4), SELE(2) 4461475 15 14 15 12 7 0 2 3 3 0 0.938 1.000 1.000 586 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 HGSNAT(1), HPSE(3), HPSE2(2), LCT(3), SPAM1(4) 8756292 13 13 12 7 6 3 0 4 0 0 0.790 1.000 1.000 587 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASS(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2), HADHA(1) 15800659 13 13 13 11 8 3 0 1 1 0 0.959 1.000 1.000 588 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), FBP1(2), FBP2(1), GOT2(1), ME1(1), PGK1(1), PGK2(1), PKLR(1), RPE(1), TKTL1(1), TKTL2(1) 8542740 12 12 12 10 5 2 0 5 0 0 0.972 1.000 1.000 589 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(4), BST1(1), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5E(2), NUDT12(1) 9152517 12 12 11 7 4 3 2 3 0 0 0.786 1.000 1.000 590 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), FBP1(2), FBP2(1), G6PD(1), PGLS(1), PGM1(1), PRPS1L1(2), PRPS2(2), RPE(1) 8685122 12 12 12 8 5 2 2 3 0 0 0.882 1.000 1.000 591 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), FBP1(2), FBP2(1), GOT2(1), ME1(1), ME2(1), PGK1(1), PKLR(1), RPE(1) 7645487 10 10 10 8 3 2 0 5 0 0 0.964 1.000 1.000 592 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR2(1), IFNB1(1), NFKB1(1), TNFRSF11A(2), TNFSF11(1) 4722990 8 8 8 5 3 3 0 2 0 0 0.834 1.000 1.000 593 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(2), B3GALT5(1), ST3GAL1(1), ST8SIA1(1) 4560397 5 5 5 6 1 0 0 4 0 0 0.995 1.000 1.000 594 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FOS(1), FYN(1), THBS1(2) 3125230 5 5 5 4 2 1 1 1 0 0 0.869 1.000 1.000 595 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(3), KDELR1(1) 6871795 4 4 4 4 1 2 0 1 0 0 0.939 1.000 1.000 596 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), PFKL(1), PGK1(1), PKLR(1) 3943946 4 4 4 3 2 0 0 2 0 0 0.904 1.000 1.000 597 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT5(1), FUT3(2) 3062162 4 4 4 3 3 0 0 1 0 0 0.869 1.000 1.000 598 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(1), UQCRC1(1) 2803186 3 3 3 3 0 1 1 1 0 0 0.927 1.000 1.000 599 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 LCT(3) 6135585 3 3 3 6 1 1 0 1 0 0 0.996 1.000 1.000 600 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), PON1(2) 3832924 3 3 3 5 1 0 0 2 0 0 0.997 1.000 1.000 601 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASS(1), KARS(2) 2948262 3 3 3 3 2 0 0 1 0 0 0.965 1.000 1.000 602 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(1), PRKAR2B(1) 4277470 2 2 2 2 0 0 0 2 0 0 0.955 1.000 1.000 603 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 ST3GAL1(1), ST8SIA1(1) 4298312 2 2 2 6 1 0 0 1 0 0 1.000 1.000 1.000 604 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(2) 852776 2 2 2 2 1 1 0 0 0 0 0.880 1.000 1.000 605 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1) 2054840 1 1 1 2 1 0 0 0 0 0 0.981 1.000 1.000 606 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 ESCO1(1) 7032636 1 1 1 2 0 1 0 0 0 0 0.967 1.000 1.000 607 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 SUCLA2(1) 3977034 1 1 1 3 0 1 0 0 0 0 0.988 1.000 1.000 608 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 P2RY2(1) 2526610 1 1 1 2 1 0 0 0 0 0 0.945 1.000 1.000 609 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR2(1) 2661386 1 1 1 2 0 0 1 0 0 0 0.985 1.000 1.000 610 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 214514 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 611 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 948253 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 1319270 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 647612 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 722306 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 1820179 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 1430860 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000