Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Syndecan-1-mediated signaling events	19.0	649.0	34.0	-0.108	0.031	1000.0	-1000.0	-0.028	-1000.0
IL23-mediated signaling events	17.0	1058.0	60.0	-0.412	0.032	1000.0	-1000.0	-0.113	-1000.0
Endothelins	15.0	1525.0	96.0	-0.153	0.067	1000.0	-1000.0	-0.047	-1000.0
Signaling mediated by p38-alpha and p38-beta	15.0	661.0	44.0	-0.088	0.038	1000.0	-1000.0	-0.027	-1000.0
TCR signaling in naïve CD8+ T cells	15.0	1464.0	93.0	-0.292	0.331	1000.0	-1000.0	-0.037	-1000.0
Angiopoietin receptor Tie2-mediated signaling	15.0	1321.0	88.0	-0.179	0.032	1000.0	-1000.0	-0.058	-1000.0
Ceramide signaling pathway	14.0	1091.0	76.0	-0.125	0.047	1000.0	-1000.0	-0.03	-1000.0
E-cadherin signaling events	14.0	71.0	5.0	-0.042	0.032	1000.0	-1000.0	0.019	-1000.0
Ephrin A  reverse signaling	13.0	96.0	7.0	-0.042	0.003	1000.0	-1000.0	-0.017	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	13.0	963.0	74.0	-0.106	0.074	1000.0	-1000.0	-0.054	-1000.0
EGFR-dependent Endothelin signaling events	13.0	276.0	21.0	-0.071	0.047	1000.0	-1000.0	-0.039	-1000.0
Syndecan-4-mediated signaling events	13.0	880.0	67.0	-0.123	0.032	1000.0	-1000.0	-0.038	-1000.0
HIF-1-alpha transcription factor network	12.0	934.0	76.0	-0.148	0.045	1000.0	-1000.0	-0.072	-1000.0
Reelin signaling pathway	12.0	693.0	56.0	-0.075	0.061	1000.0	-1000.0	-0.029	-1000.0
IL12-mediated signaling events	11.0	1028.0	87.0	-0.279	0.044	1000.0	-1000.0	-0.069	-1000.0
Arf6 signaling events	11.0	740.0	62.0	-0.071	0.068	1000.0	-1000.0	-0.033	-1000.0
IL4-mediated signaling events	11.0	1066.0	91.0	-0.455	0.318	1000.0	-1000.0	-0.128	-1000.0
Signaling events regulated by Ret tyrosine kinase	11.0	956.0	82.0	-0.106	0.032	1000.0	-1000.0	-0.042	-1000.0
ErbB2/ErbB3 signaling events	10.0	674.0	65.0	-0.089	0.046	1000.0	-1000.0	-0.072	-1000.0
Caspase cascade in apoptosis	9.0	727.0	74.0	-0.141	0.044	1000.0	-1000.0	-0.035	-1000.0
Visual signal transduction: Cones	9.0	345.0	38.0	-0.069	0.035	1000.0	-1000.0	-0.027	-1000.0
Thromboxane A2 receptor signaling	9.0	1003.0	105.0	-0.077	0.043	1000.0	-1000.0	-0.031	-1000.0
FOXA2 and FOXA3 transcription factor networks	9.0	445.0	46.0	-0.239	0.032	1000.0	-1000.0	-0.108	-1000.0
EPO signaling pathway	9.0	527.0	55.0	-0.011	0.076	1000.0	-1000.0	-0.033	-1000.0
PDGFR-alpha signaling pathway	9.0	400.0	44.0	-0.053	0.038	1000.0	-1000.0	-0.032	-1000.0
HIF-2-alpha transcription factor network	9.0	387.0	43.0	-0.092	0.059	1000.0	-1000.0	-0.047	-1000.0
Effects of Botulinum toxin	9.0	247.0	26.0	-0.05	0.031	1000.0	-1000.0	-0.015	-1000.0
E-cadherin signaling in the nascent adherens junction	9.0	711.0	76.0	-0.048	0.056	1000.0	-1000.0	-0.055	-1000.0
E-cadherin signaling in keratinocytes	9.0	392.0	43.0	-0.071	0.036	1000.0	-1000.0	-0.032	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	8.0	297.0	34.0	-0.035	0.055	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by the Hedgehog family	8.0	442.0	52.0	-0.074	0.044	1000.0	-1000.0	-0.027	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	696.0	85.0	-0.06	0.088	1000.0	-1000.0	-0.037	-1000.0
p75(NTR)-mediated signaling	8.0	1080.0	125.0	-0.071	0.081	1000.0	-1000.0	-0.062	-1000.0
Glypican 1 network	8.0	425.0	48.0	-0.086	0.06	1000.0	-1000.0	-0.032	-1000.0
Glucocorticoid receptor regulatory network	8.0	982.0	114.0	-0.274	0.176	1000.0	-1000.0	-0.053	-1000.0
TCGA08_rtk_signaling	8.0	221.0	26.0	-0.071	0.094	1000.0	-1000.0	-0.006	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	8.0	544.0	68.0	-0.2	0.039	1000.0	-1000.0	-0.078	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	420.0	54.0	-0.047	0.046	1000.0	-1000.0	-0.034	-1000.0
JNK signaling in the CD4+ TCR pathway	7.0	130.0	17.0	-0.137	0.044	1000.0	-1000.0	-0.03	-1000.0
Fc-epsilon receptor I signaling in mast cells	7.0	720.0	97.0	-0.133	0.052	1000.0	-1000.0	-0.049	-1000.0
amb2 Integrin signaling	7.0	594.0	82.0	-0.119	0.042	1000.0	-1000.0	-0.045	-1000.0
IL1-mediated signaling events	7.0	447.0	62.0	-0.047	0.05	1000.0	-1000.0	-0.027	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	7.0	376.0	52.0	-0.077	0.079	1000.0	-1000.0	-0.049	-1000.0
FAS signaling pathway (CD95)	7.0	335.0	47.0	-0.171	0.048	1000.0	-1000.0	-0.047	-1000.0
Retinoic acid receptors-mediated signaling	7.0	429.0	58.0	-0.082	0.058	1000.0	-1000.0	-0.036	-1000.0
EPHB forward signaling	7.0	597.0	85.0	-0.053	0.079	1000.0	-1000.0	-0.054	-1000.0
Wnt signaling	7.0	50.0	7.0	-0.018	0.026	1000.0	-1000.0	-0.019	-1000.0
TCGA08_retinoblastoma	7.0	63.0	8.0	-0.019	0.078	1000.0	-1000.0	-0.004	-1000.0
Visual signal transduction: Rods	7.0	378.0	52.0	-0.068	0.031	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	7.0	562.0	78.0	-0.039	0.057	1000.0	-1000.0	-0.043	-1000.0
Osteopontin-mediated events	6.0	265.0	38.0	-0.081	0.034	1000.0	-1000.0	-0.033	-1000.0
Noncanonical Wnt signaling pathway	6.0	181.0	26.0	-0.052	0.032	1000.0	-1000.0	-0.034	-1000.0
Nectin adhesion pathway	6.0	421.0	63.0	-0.042	0.057	1000.0	-1000.0	-0.044	-1000.0
S1P1 pathway	6.0	224.0	36.0	-0.046	0.032	1000.0	-1000.0	-0.031	-1000.0
IL2 signaling events mediated by PI3K	6.0	381.0	58.0	-0.226	0.046	1000.0	-1000.0	-0.044	-1000.0
Integrins in angiogenesis	6.0	505.0	84.0	-0.052	0.077	1000.0	-1000.0	-0.045	-1000.0
Glypican 2 network	6.0	27.0	4.0	0.001	0.008	1000.0	-1000.0	0.018	-1000.0
Nongenotropic Androgen signaling	6.0	363.0	52.0	-0.043	0.04	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	6.0	760.0	125.0	-0.038	0.059	1000.0	-1000.0	-0.048	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	214.0	33.0	-0.055	0.06	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by PTP1B	5.0	386.0	76.0	-0.091	0.047	1000.0	-1000.0	-0.031	-1000.0
BMP receptor signaling	5.0	443.0	81.0	-0.049	0.06	1000.0	-1000.0	-0.03	-1000.0
Ephrin B reverse signaling	5.0	263.0	48.0	-0.027	0.051	1000.0	-1000.0	-0.021	-1000.0
Syndecan-3-mediated signaling events	5.0	193.0	35.0	-0.071	0.081	1000.0	-1000.0	-0.013	-1000.0
Calcium signaling in the CD4+ TCR pathway	5.0	167.0	31.0	-0.08	0.029	1000.0	-1000.0	-0.032	-1000.0
LPA receptor mediated events	5.0	566.0	102.0	-0.159	0.058	1000.0	-1000.0	-0.063	-1000.0
BCR signaling pathway	5.0	502.0	99.0	-0.053	0.069	1000.0	-1000.0	-0.066	-1000.0
LPA4-mediated signaling events	4.0	48.0	12.0	-0.034	-0.0	1000.0	-1000.0	-0.022	-1000.0
Syndecan-2-mediated signaling events	4.0	335.0	69.0	-0.058	0.052	1000.0	-1000.0	-0.04	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	22.0	5.0	0.011	0.025	1000.0	-1000.0	0.017	-1000.0
PLK1 signaling events	4.0	369.0	85.0	-0.021	0.049	1000.0	-1000.0	-0.026	-1000.0
mTOR signaling pathway	4.0	264.0	53.0	-0.018	0.073	1000.0	-1000.0	-0.033	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	278.0	68.0	-0.027	0.059	1000.0	-1000.0	-0.031	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	170.0	37.0	-0.035	0.045	1000.0	-1000.0	-0.027	-1000.0
ceramide signaling pathway	4.0	199.0	49.0	-0.026	0.045	1000.0	-1000.0	-0.034	-1000.0
Canonical Wnt signaling pathway	4.0	227.0	51.0	-0.071	0.103	1000.0	-1000.0	-0.027	-1000.0
IL6-mediated signaling events	4.0	343.0	75.0	-0.057	0.069	1000.0	-1000.0	-0.051	-1000.0
IL2 signaling events mediated by STAT5	4.0	106.0	22.0	-0.083	0.032	1000.0	-1000.0	-0.033	-1000.0
IGF1 pathway	4.0	259.0	57.0	-0.046	0.073	1000.0	-1000.0	-0.034	-1000.0
Plasma membrane estrogen receptor signaling	4.0	413.0	86.0	-0.034	0.055	1000.0	-1000.0	-0.042	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	584.0	120.0	-0.068	0.085	1000.0	-1000.0	-0.044	-1000.0
FOXM1 transcription factor network	4.0	253.0	51.0	-0.094	0.057	1000.0	-1000.0	-0.105	-1000.0
S1P4 pathway	4.0	120.0	25.0	-0.0	0.053	1000.0	-1000.0	-0.021	-1000.0
Aurora B signaling	4.0	310.0	67.0	-0.104	0.063	1000.0	-1000.0	-0.037	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	501.0	136.0	-0.242	0.125	1000.0	-1000.0	-0.038	-1000.0
Coregulation of Androgen receptor activity	3.0	302.0	76.0	-0.079	0.058	1000.0	-1000.0	-0.023	-1000.0
ErbB4 signaling events	3.0	219.0	69.0	-0.071	0.046	1000.0	-1000.0	-0.03	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	200.0	61.0	-0.07	0.081	1000.0	-1000.0	-0.031	-1000.0
Arf6 downstream pathway	3.0	156.0	43.0	-0.046	0.049	1000.0	-1000.0	-0.022	-1000.0
Aurora C signaling	3.0	25.0	7.0	-0.0	0.032	1000.0	-1000.0	-0.014	-1000.0
TRAIL signaling pathway	3.0	161.0	48.0	-0.041	0.079	1000.0	-1000.0	-0.026	-1000.0
S1P5 pathway	3.0	63.0	17.0	-0.025	0.032	1000.0	-1000.0	-0.011	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	257.0	83.0	-0.055	0.061	1000.0	-1000.0	-0.025	-1000.0
TCGA08_p53	3.0	27.0	7.0	-0.015	0.03	1000.0	-1000.0	-0.016	-1000.0
FoxO family signaling	3.0	210.0	64.0	-0.069	0.072	1000.0	-1000.0	-0.058	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	176.0	45.0	-0.073	0.058	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events	3.0	257.0	73.0	-0.035	0.091	1000.0	-1000.0	-0.041	-1000.0
Insulin Pathway	3.0	258.0	74.0	-0.062	0.078	1000.0	-1000.0	-0.044	-1000.0
PDGFR-beta signaling pathway	3.0	320.0	97.0	-0.024	0.084	1000.0	-1000.0	-0.051	-1000.0
Regulation of Androgen receptor activity	3.0	247.0	70.0	-0.112	0.041	1000.0	-1000.0	-0.032	-1000.0
Cellular roles of Anthrax toxin	2.0	116.0	39.0	-0.041	0.042	1000.0	-1000.0	-0.018	-1000.0
Insulin-mediated glucose transport	2.0	93.0	32.0	-0.025	0.063	1000.0	-1000.0	-0.024	-1000.0
IFN-gamma pathway	2.0	180.0	68.0	-0.055	0.066	1000.0	-1000.0	-0.052	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	101.0	36.0	-0.032	0.045	1000.0	-1000.0	-0.03	-1000.0
Atypical NF-kappaB pathway	2.0	63.0	31.0	-0.015	0.044	1000.0	-1000.0	-0.027	-1000.0
Regulation of p38-alpha and p38-beta	2.0	112.0	54.0	-0.063	0.052	1000.0	-1000.0	-0.048	-1000.0
IL27-mediated signaling events	2.0	146.0	51.0	-0.074	0.045	1000.0	-1000.0	-0.06	-1000.0
Arf6 trafficking events	2.0	145.0	71.0	-0.055	0.057	1000.0	-1000.0	-0.027	-1000.0
Regulation of Telomerase	2.0	285.0	102.0	-0.102	0.083	1000.0	-1000.0	-0.051	-1000.0
VEGFR1 specific signals	2.0	137.0	56.0	-0.03	0.058	1000.0	-1000.0	-0.04	-1000.0
S1P3 pathway	2.0	115.0	42.0	-0.018	0.041	1000.0	-1000.0	-0.031	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.025	0.025	1000.0	-1000.0	-0.021	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	39.0	17.0	-0.0	0.055	1000.0	-1000.0	-0.027	-1000.0
Canonical NF-kappaB pathway	1.0	45.0	39.0	-0.013	0.07	1000.0	-1000.0	-0.027	-1000.0
BARD1 signaling events	1.0	64.0	57.0	-0.069	0.08	1000.0	-1000.0	-0.033	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	55.0	28.0	-0.018	0.042	1000.0	-1000.0	-0.026	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.019	0.029	1000.0	-1000.0	-0.025	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	100.0	65.0	-0.005	0.071	1000.0	-1000.0	-0.043	-1000.0
Aurora A signaling	1.0	102.0	60.0	-0.023	0.069	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class III	1.0	68.0	40.0	-0.046	0.046	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class I	1.0	120.0	104.0	-0.059	0.072	1000.0	-1000.0	-0.032	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	22.0	15.0	-0.023	0.031	1000.0	-1000.0	-0.028	-1000.0
Rapid glucocorticoid signaling	1.0	26.0	20.0	-0.017	0.038	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by PRL	1.0	35.0	34.0	-0.029	0.046	1000.0	-1000.0	-0.041	-1000.0
p38 MAPK signaling pathway	1.0	84.0	44.0	-0.018	0.042	1000.0	-1000.0	-0.022	-1000.0
Arf1 pathway	1.0	56.0	54.0	-0.067	0.055	1000.0	-1000.0	-0.016	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	13.0	23.0	-0.013	0.056	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by HDAC Class II	0.0	34.0	75.0	-0.036	0.086	1000.0	-1000.0	-0.029	-1000.0
Circadian rhythm pathway	0.0	11.0	22.0	-0.007	0.06	1000.0	-1000.0	-0.029	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.017	0.07	1000.0	-1000.0	-0.034	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.065	1000.0	-1000.0	-0.0	-1000.0
Total	749	47035	7203	-9.66070423306	7.6522598208	131000	-131000	-4.72314894262	-131000