Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.018 0.027 0.161 8.0 -0.085 19.0 27.0 IHH 0.038 0.022 0.115 15.0 -0.046 13.0 28.0 SHH Np/Cholesterol/GAS1 0.013 0.02 -9999.0 0.0 -0.044 36.0 36.0 LRPAP1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.013 0.02 0.044 36.0 -9999.0 0.0 36.0 SMO/beta Arrestin2 0.067 0.057 -9999.0 0.0 -0.144 1.0 1.0 SMO 0.013 0.019 0.137 3.0 -9999.0 0.0 3.0 AKT1 0.004 0.08 -9999.0 0.0 -0.369 15.0 15.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 STIL 0.024 0.086 0.17 127.0 -9999.0 0.0 127.0 DHH N/PTCH2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.017 0.015 -9999.0 0.0 -0.059 13.0 13.0 PIK3CA 0.028 0.019 -9999.0 0.0 -0.07 17.0 17.0 DHH -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.016 0.026 0.157 7.0 -0.104 6.0 13.0 determination of left/right symmetry 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 PIK3R1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.016 0.025 0.157 7.0 -0.104 6.0 13.0 IHH N/Hhip 0.025 0.013 0.071 17.0 -0.022 6.0 23.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 pancreas development 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.039 0.023 -9999.0 0.0 -0.054 16.0 16.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.021 0.032 -9999.0 0.0 -0.07 55.0 55.0 somite specification 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 SHH Np/Cholesterol/PTCH1 0.014 0.018 -9999.0 0.0 -0.065 5.0 5.0 SHH Np/Cholesterol/PTCH2 0.018 0.014 -9999.0 0.0 -0.031 4.0 4.0 SHH Np/Cholesterol/Megalin 0.018 0.014 -9999.0 0.0 -0.034 5.0 5.0 SHH -0.015 0.011 0.0 169.0 -9999.0 0.0 169.0 catabolic process 0.021 0.018 -9999.0 0.0 -0.069 13.0 13.0 SMO/Vitamin D3 0.016 0.032 0.181 13.0 -9999.0 0.0 13.0 SHH Np/Cholesterol/Hhip -0.011 0.007 0.0 165.0 -9999.0 0.0 165.0 LRP2 0.032 0.005 -9999.0 0.0 -0.07 1.0 1.0 receptor-mediated endocytosis 0.012 0.027 0.154 12.0 -9999.0 0.0 12.0 SHH Np/Cholesterol/BOC -0.011 0.007 0.0 165.0 -9999.0 0.0 165.0 SHH Np/Cholesterol/CDO 0.018 0.014 -9999.0 0.0 -0.031 4.0 4.0 mesenchymal cell differentiation 0.011 0.007 -9999.0 0.0 0.0 165.0 165.0 mol:Vitamin D3 0.065 0.082 0.191 146.0 -9999.0 0.0 146.0 IHH N/PTCH2 0.049 0.016 0.106 8.0 -0.034 8.0 16.0 CDON 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.036 0.022 -9999.0 0.0 -0.065 20.0 20.0 Megalin/LRPAP1 0.048 0.007 -9999.0 0.0 -0.054 1.0 1.0 PTCH2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.011 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.021 0.018 -9999.0 0.0 -0.069 13.0 13.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0