Correlation between gene mutation status and molecular subtypes

Glioma (Primary solid tumor)

02 April 2015 | analyses__2015_04_02

Maintainer Information

Citation Information

Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)

Cite as Broad Institute TCGA Genome Data Analysis Center (2015): Correlation between gene mutation status and molecular subtypes. Broad Institute of MIT and Harvard. doi:10.7908/C1X92992

Overview

Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and molecular subtypes.

Summary

Testing the association between mutation status of 188 genes and 12 molecular subtypes across 796 patients, 190 significant findings detected with P value < 0.05 and Q value < 0.25.

IDH1 mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CNMF', 'MIR_CHIERARCHICAL', 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
TP53 mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CNMF', 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
ATRX mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CNMF', 'MIR_CHIERARCHICAL', 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
PTEN mutation correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
CIC mutation correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
PIK3CA mutation correlated to 'METHLYATION_CNMF', 'MIRSEQ_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
NF1 mutation correlated to 'MRNA_CHIERARCHICAL', 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
PIK3R1 mutation correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
NOTCH1 mutation correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
FUBP1 mutation correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
RB1 mutation correlated to 'MRNA_CHIERARCHICAL', 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
IDH2 mutation correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', and 'MIRSEQ_MATURE_CNMF'.
ARID1A mutation correlated to 'CN_CNMF' and 'MRNASEQ_CHIERARCHICAL'.
NIPBL mutation correlated to 'METHLYATION_CNMF' and 'MIRSEQ_MATURE_CNMF'.
SMARCA4 mutation correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
CREBZF mutation correlated to 'METHLYATION_CNMF' and 'MIRSEQ_CHIERARCHICAL'.
RPL5 mutation correlated to 'METHLYATION_CNMF'.
STAG2 mutation correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', and 'MIRSEQ_CHIERARCHICAL'.
REN mutation correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
PLCG1 mutation correlated to 'CN_CNMF'.
SLC26A3 mutation correlated to 'CN_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
ZBTB20 mutation correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', and 'MIRSEQ_CHIERARCHICAL'.
TRERF1 mutation correlated to 'MRNASEQ_CHIERARCHICAL'.
ZMIZ1 mutation correlated to 'MIRSEQ_MATURE_CNMF'.
PTPN11 mutation correlated to 'MIR_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
DSP mutation correlated to 'MIRSEQ_CHIERARCHICAL'.
BRAF mutation correlated to 'METHLYATION_CNMF'.
EGFR mutation correlated to 'MRNA_CNMF', 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
SEMG2 mutation correlated to 'CN_CNMF'.
AK7 mutation correlated to 'MIRSEQ_CHIERARCHICAL' and 'MIRSEQ_MATURE_CHIERARCHICAL'.
SETD2 mutation correlated to 'MRNA_CNMF'.
PDGFRA mutation correlated to 'MRNA_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', and 'MIRSEQ_CHIERARCHICAL'.
FAM47C mutation correlated to 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
NOTCH2 mutation correlated to 'MIR_CHIERARCHICAL'.
NUP210L mutation correlated to 'METHLYATION_CNMF' and 'MRNASEQ_CNMF'.
ZDHHC4 mutation correlated to 'METHLYATION_CNMF'.
BCLAF1 mutation correlated to 'MRNASEQ_CHIERARCHICAL'.
MYT1 mutation correlated to 'MRNASEQ_CHIERARCHICAL'.
DOCK5 mutation correlated to 'MRNASEQ_CNMF' and 'MRNASEQ_CHIERARCHICAL'.
PRKCD mutation correlated to 'CN_CNMF'.
USP11 mutation correlated to 'MRNASEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
RASGRF2 mutation correlated to 'MIRSEQ_CHIERARCHICAL'.
SOX13 mutation correlated to 'METHLYATION_CNMF'.
ACADS mutation correlated to 'CN_CNMF'.
DSG3 mutation correlated to 'CN_CNMF' and 'MRNASEQ_CHIERARCHICAL'.
TMPRSS6 mutation correlated to 'MRNASEQ_CNMF' and 'MRNASEQ_CHIERARCHICAL'.
BBS9 mutation correlated to 'METHLYATION_CNMF'.
ATF7IP2 mutation correlated to 'CN_CNMF' and 'MIRSEQ_CHIERARCHICAL'.
QKI mutation correlated to 'CN_CNMF'.
MTMR12 mutation correlated to 'MRNASEQ_CNMF'.
AMBRA1 mutation correlated to 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', and 'MIRSEQ_CHIERARCHICAL'.
SOX4 mutation correlated to 'MIRSEQ_CNMF'.
LYPD4 mutation correlated to 'METHLYATION_CNMF'.
SEMA3C mutation correlated to 'CN_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
FMR1 mutation correlated to 'MRNASEQ_CHIERARCHICAL'.
ZC3H11A mutation correlated to 'METHLYATION_CNMF', 'MRNASEQ_CNMF', and 'MIRSEQ_CHIERARCHICAL'.
NKPD1 mutation correlated to 'CN_CNMF'.
SEC14L4 mutation correlated to 'CN_CNMF'.
KEL mutation correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CHIERARCHICAL', and 'MIRSEQ_MATURE_CHIERARCHICAL'.

Results

Overview of the results

Table 1. Get Full Table Overview of the association between mutation status of 188 genes and 12 molecular subtypes. Shown in the table are P values (Q values). Thresholded by P value < 0.05 and Q value < 0.25, 190 significant findings detected.


		Clinical Features	MRNA CNMF	MRNA CHIERARCHICAL	MIR CNMF	MIR CHIERARCHICAL	CN CNMF	METHLYATION CNMF	MRNASEQ CNMF	MRNASEQ CHIERARCHICAL	MIRSEQ CNMF	MIRSEQ CHIERARCHICAL	MIRSEQ MATURE CNMF	MIRSEQ MATURE CHIERARCHICAL
	nMutated (%)	nWild-Type	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test
IDH1	412 (52%)	384	0.00011 (0.00327)	1e-05 (0.00037)	1e-05 (0.00037)	0.003 (0.0564)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	5e-05 (0.00163)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)
ATRX	211 (27%)	585	0.00209 (0.0414)	1e-05 (0.00037)	0.00659 (0.107)	0.0179 (0.221)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	3e-05 (0.00104)	0.259 (0.996)	1e-05 (0.00037)
TP53	327 (41%)	469	0.00065 (0.0159)	1e-05 (0.00037)	0.00156 (0.0335)	0.149 (0.814)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	0.0536 (0.432)	1e-05 (0.00037)
EGFR	109 (14%)	687	0.00651 (0.106)	0.056 (0.439)	0.51 (1.00)	0.14 (0.786)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	0.0106 (0.152)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)
PTEN	111 (14%)	685	0.115 (0.692)	0.0756 (0.527)	0.0264 (0.284)	0.642 (1.00)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	0.0034 (0.0624)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)
CIC	109 (14%)	687					1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)
NF1	62 (8%)	734	0.0812 (0.558)	0.00027 (0.00708)	0.0252 (0.276)	0.933 (1.00)	0.00264 (0.0509)	1e-05 (0.00037)	0.00012 (0.00347)	0.00177 (0.0363)	0.337 (1.00)	0.00012 (0.00347)	0.00548 (0.0937)	1e-05 (0.00037)
NOTCH1	42 (5%)	754					1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	0.00021 (0.00571)	0.0042 (0.0757)	0.00168 (0.0354)	0.00015 (0.00418)
FUBP1	47 (6%)	749					1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	1e-05 (0.00037)	2e-05 (0.000728)	0.0011 (0.0248)	0.00756 (0.117)	1e-05 (0.00037)
IDH2	20 (3%)	776					0.00036 (0.00934)	6e-05 (0.00191)	3e-05 (0.00104)	1e-05 (0.00037)	0.0102 (0.148)	0.00065 (0.0159)	0.00297 (0.0563)	0.0469 (0.407)
KEL	24 (3%)	772	0.548 (1.00)	0.212 (0.91)	0.722 (1.00)	0.886 (1.00)	0.00103 (0.0235)	0.00103 (0.0235)	3e-05 (0.00104)	0.00204 (0.0407)	0.041 (0.381)	0.00015 (0.00418)	0.148 (0.81)	0.00473 (0.0827)
RB1	30 (4%)	766	0.0339 (0.335)	0.0166 (0.211)	0.133 (0.758)	0.923 (1.00)	1e-05 (0.00037)	1e-05 (0.00037)	6e-05 (0.00191)	5e-05 (0.00163)	0.599 (1.00)	0.034 (0.335)	0.78 (1.00)	0.248 (0.976)
STAG2	16 (2%)	780	0.39 (1.00)	0.698 (1.00)	0.714 (1.00)	0.587 (1.00)	8e-05 (0.00251)	0.00061 (0.0153)	0.0001 (0.00301)	0.00124 (0.0274)	0.594 (1.00)	0.0137 (0.183)	0.473 (1.00)	0.235 (0.953)
ZBTB20	22 (3%)	774					0.00013 (0.00371)	4e-05 (0.00137)	9e-05 (0.00278)	5e-05 (0.00163)	0.158 (0.838)	0.0205 (0.244)	0.0404 (0.377)	0.0317 (0.319)
PDGFRA	22 (3%)	774	0.0203 (0.244)	0.134 (0.762)	0.76 (1.00)	0.0924 (0.6)	0.477 (1.00)	0.155 (0.83)	0.00146 (0.0317)	0.0148 (0.192)	0.0007 (0.017)	0.0013 (0.0285)	0.854 (1.00)	0.186 (0.896)
SMARCA4	27 (3%)	769					0.00174 (0.036)	0.0162 (0.208)	0.00545 (0.0937)	0.00991 (0.145)	0.306 (1.00)	0.242 (0.962)	0.872 (1.00)	0.163 (0.842)
PTPN11	11 (1%)	785	1 (1.00)	0.787 (1.00)	0.00686 (0.11)	1 (1.00)	0.56 (1.00)	0.0314 (0.319)	0.228 (0.937)	0.267 (0.997)	0.22 (0.922)	0.00559 (0.0944)	0.0156 (0.202)	0.00245 (0.0481)
PIK3CA	73 (9%)	723	0.792 (1.00)	0.164 (0.843)	0.574 (1.00)	1 (1.00)	0.601 (1.00)	1e-05 (0.00037)	0.347 (1.00)	0.0329 (0.328)	0.00963 (0.143)	0.0398 (0.372)	0.327 (1.00)	0.00088 (0.0209)
SLC26A3	11 (1%)	785	0.941 (1.00)	0.769 (1.00)	0.466 (1.00)	0.362 (1.00)	0.0112 (0.158)	0.0231 (0.26)	0.00444 (0.0789)	0.00611 (0.101)	0.0451 (0.402)	0.0268 (0.286)	1 (1.00)	0.185 (0.896)
FAM47C	23 (3%)	773	0.484 (1.00)	0.0583 (0.452)	0.406 (1.00)	0.843 (1.00)	0.331 (1.00)	0.543 (1.00)	0.0509 (0.43)	0.00462 (0.0814)	0.611 (1.00)	0.0923 (0.6)	0.00815 (0.123)	0.00356 (0.0648)
USP11	10 (1%)	786	0.0383 (0.368)	0.306 (1.00)	0.0317 (0.319)	0.606 (1.00)	0.772 (1.00)	0.608 (1.00)	0.00988 (0.145)	0.328 (1.00)	0.202 (0.896)	0.0142 (0.187)	0.0629 (0.468)	0.0104 (0.151)
AMBRA1	6 (1%)	790					1 (1.00)	0.248 (0.976)	0.333 (1.00)	0.0145 (0.189)	0.00248 (0.0482)	0.00159 (0.0338)	0.272 (0.998)	0.84 (1.00)
SEMA3C	12 (2%)	784	0.481 (1.00)	0.175 (0.871)	0.119 (0.704)	0.85 (1.00)	0.00112 (0.025)		0.00048 (0.0122)	0.00086 (0.0206)
ZC3H11A	5 (1%)	791					0.405 (1.00)	0.0174 (0.216)	0.00724 (0.114)	0.0386 (0.369)	0.24 (0.961)	0.0068 (0.11)	0.332 (1.00)	0.0668 (0.489)
PIK3R1	54 (7%)	742	0.749 (1.00)	0.192 (0.896)	0.2 (0.896)	0.53 (1.00)	0.0172 (0.215)	0.0001 (0.00301)	0.249 (0.976)	0.927 (1.00)	0.0882 (0.587)	0.585 (1.00)	0.962 (1.00)	0.63 (1.00)
ARID1A	22 (3%)	774					0.0206 (0.244)	0.0219 (0.254)	0.0252 (0.276)	0.00561 (0.0944)	0.313 (1.00)	0.605 (1.00)	0.0848 (0.574)	0.0298 (0.305)
NIPBL	20 (3%)	776					0.0283 (0.293)	0.00021 (0.00571)	0.0532 (0.43)	0.0466 (0.407)	0.448 (1.00)	0.175 (0.871)	0.0112 (0.158)	0.0608 (0.461)
CREBZF	9 (1%)	787					0.0366 (0.356)	0.00042 (0.0108)	0.0215 (0.251)	0.0679 (0.496)	0.202 (0.896)	0.0138 (0.183)	0.114 (0.692)	0.0532 (0.43)
REN	7 (1%)	789	0.477 (1.00)	0.416 (1.00)	0.0738 (0.523)	0.513 (1.00)	0.00277 (0.053)	0.00315 (0.0582)	0.203 (0.896)	0.785 (1.00)
AK7	9 (1%)	787	0.137 (0.774)	0.125 (0.722)	0.587 (1.00)	0.236 (0.955)	0.0515 (0.43)	0.0711 (0.514)	0.165 (0.845)	0.0875 (0.584)	0.0826 (0.565)	0.0017 (0.0355)	0.271 (0.998)	0.00095 (0.0223)
NUP210L	12 (2%)	784	0.811 (1.00)	0.425 (1.00)	0.414 (1.00)	0.358 (1.00)	0.197 (0.896)	0.0127 (0.173)	0.0167 (0.211)	0.208 (0.901)	0.4 (1.00)	0.0754 (0.527)	0.163 (0.842)	0.356 (1.00)
DOCK5	20 (3%)	776	0.261 (0.996)	0.908 (1.00)	0.0607 (0.461)	0.3 (1.00)	0.026 (0.282)	0.0337 (0.335)	0.012 (0.167)	0.00608 (0.101)	0.0391 (0.369)	0.0667 (0.489)	0.728 (1.00)	0.461 (1.00)
DSG3	11 (1%)	785	0.145 (0.8)	0.641 (1.00)	0.656 (1.00)	1 (1.00)	0.00096 (0.0223)	0.0226 (0.257)	0.0423 (0.389)	0.00915 (0.137)
TMPRSS6	9 (1%)	787	0.666 (1.00)	0.703 (1.00)	0.662 (1.00)	0.265 (0.996)	0.0502 (0.426)	0.0228 (0.258)	0.00181 (0.0368)	0.00707 (0.112)	0.189 (0.896)	0.154 (0.829)	0.649 (1.00)	0.437 (1.00)
ATF7IP2	8 (1%)	788	0.911 (1.00)	1 (1.00)	0.288 (1.00)	0.105 (0.657)	0.00314 (0.0582)	0.311 (1.00)	0.0215 (0.251)	0.102 (0.65)	1 (1.00)	0.00755 (0.117)	0.647 (1.00)	0.0889 (0.59)
RPL5	10 (1%)	786	0.383 (1.00)	0.51 (1.00)	0.869 (1.00)	0.467 (1.00)	0.262 (0.996)	0.0138 (0.183)	0.0223 (0.257)	0.189 (0.896)	0.0928 (0.6)	0.0518 (0.43)	1 (1.00)	0.511 (1.00)
PLCG1	11 (1%)	785	0.642 (1.00)	0.927 (1.00)	0.868 (1.00)	0.841 (1.00)	0.0111 (0.158)	0.212 (0.91)	0.574 (1.00)	0.272 (0.998)	0.027 (0.286)	0.0651 (0.481)	0.0538 (0.432)	0.15 (0.817)
TRERF1	7 (1%)	789					0.309 (1.00)	0.864 (1.00)	1 (1.00)	0.0187 (0.227)	0.389 (1.00)	0.757 (1.00)	0.104 (0.656)	0.353 (1.00)
ZMIZ1	13 (2%)	783	0.505 (1.00)	0.912 (1.00)	0.645 (1.00)	0.446 (1.00)	0.233 (0.951)	0.328 (1.00)	0.868 (1.00)	0.344 (1.00)	0.481 (1.00)	0.676 (1.00)	0.0183 (0.223)	0.418 (1.00)
DSP	21 (3%)	775	0.489 (1.00)	0.962 (1.00)	0.57 (1.00)	0.0747 (0.525)	0.0704 (0.511)	0.0446 (0.401)	0.669 (1.00)	0.727 (1.00)	0.71 (1.00)	0.0163 (0.208)	0.914 (1.00)	0.548 (1.00)
BRAF	11 (1%)	785	0.766 (1.00)	0.711 (1.00)	0.321 (1.00)	0.0294 (0.302)	0.409 (1.00)	0.00022 (0.00591)	0.0496 (0.422)	0.359 (1.00)	0.263 (0.996)	0.0903 (0.596)	0.0614 (0.463)	0.196 (0.896)
SEMG2	13 (2%)	783	0.501 (1.00)	0.423 (1.00)	0.548 (1.00)	0.921 (1.00)	0.00024 (0.00637)	0.0361 (0.353)	0.0215 (0.251)	0.0243 (0.269)
SETD2	13 (2%)	783	0.00573 (0.0958)	0.353 (1.00)	0.458 (1.00)	1 (1.00)	0.619 (1.00)	0.174 (0.871)	0.112 (0.684)	0.38 (1.00)	0.605 (1.00)	0.0912 (0.6)	0.853 (1.00)	0.378 (1.00)
NOTCH2	13 (2%)	783	0.784 (1.00)	0.223 (0.924)	0.0601 (0.458)	0.017 (0.213)	0.62 (1.00)	0.409 (1.00)	0.853 (1.00)	0.237 (0.955)	0.212 (0.91)	0.0391 (0.369)	0.362 (1.00)	0.542 (1.00)
ZDHHC4	4 (1%)	792			0.162 (0.842)	1 (1.00)	0.184 (0.896)	0.0121 (0.168)
BCLAF1	12 (2%)	784	0.328 (1.00)	0.771 (1.00)	0.628 (1.00)	0.425 (1.00)	0.451 (1.00)	0.173 (0.871)	0.104 (0.655)	0.00544 (0.0937)	0.267 (0.997)	0.508 (1.00)	0.33 (1.00)	0.668 (1.00)
MYT1	6 (1%)	790					0.134 (0.761)	0.27 (0.998)	0.88 (1.00)	0.0181 (0.222)	0.429 (1.00)	0.758 (1.00)	0.457 (1.00)	0.941 (1.00)
PRKCD	3 (0%)	793	0.175 (0.871)	0.0838 (0.569)	0.162 (0.842)	1 (1.00)	0.00423 (0.0757)
RASGRF2	6 (1%)	790					0.695 (1.00)	0.21 (0.907)	0.334 (1.00)	0.67 (1.00)	0.0813 (0.558)	0.0132 (0.179)	0.84 (1.00)	0.637 (1.00)
SOX13	5 (1%)	791			0.776 (1.00)	1 (1.00)	0.115 (0.692)	0.0125 (0.172)	0.403 (1.00)	1 (1.00)
ACADS	5 (1%)	791	0.415 (1.00)	0.35 (1.00)	0.342 (1.00)	0.79 (1.00)	0.00765 (0.117)	0.0464 (0.407)
BBS9	5 (1%)	791					0.402 (1.00)	0.00788 (0.12)	0.159 (0.838)	0.823 (1.00)	0.33 (1.00)	0.0549 (0.435)	0.413 (1.00)	0.509 (1.00)
QKI	6 (1%)	790	0.265 (0.996)	0.0595 (0.458)	0.765 (1.00)	1 (1.00)	0.0079 (0.12)	0.313 (1.00)	0.64 (1.00)	0.272 (0.998)
MTMR12	4 (1%)	792					0.187 (0.896)	0.0456 (0.404)	0.0205 (0.244)	0.103 (0.65)
SOX4	7 (1%)	789					0.448 (1.00)	0.316 (1.00)	0.213 (0.911)	0.579 (1.00)	0.00732 (0.115)	0.119 (0.704)	0.331 (1.00)	0.175 (0.871)
LYPD4	5 (1%)	791			0.398 (1.00)	0.31 (1.00)	0.402 (1.00)	0.012 (0.167)	0.4 (1.00)	1 (1.00)
FMR1	5 (1%)	791					0.198 (0.896)	0.779 (1.00)	0.332 (1.00)	0.00187 (0.0377)	0.241 (0.962)	0.36 (1.00)	0.335 (1.00)	1 (1.00)
NKPD1	3 (0%)	793					0.0143 (0.188)	0.192 (0.896)	1 (1.00)	0.376 (1.00)	0.68 (1.00)	0.793 (1.00)	0.209 (0.904)	0.776 (1.00)
SEC14L4	3 (0%)	793					0.0135 (0.182)	0.733 (1.00)	0.644 (1.00)	0.196 (0.896)	0.191 (0.896)	0.154 (0.829)	0.112 (0.684)	0.0264 (0.284)
TCF12	19 (2%)	777	1 (1.00)	0.482 (1.00)	0.645 (1.00)	0.259 (0.996)	0.222 (0.924)	0.793 (1.00)	0.129 (0.736)	0.295 (1.00)	0.698 (1.00)	0.514 (1.00)	1 (1.00)	0.515 (1.00)
STK19	11 (1%)	785					0.591 (1.00)	0.47 (1.00)	0.352 (1.00)	0.861 (1.00)	0.17 (0.86)	0.543 (1.00)	0.921 (1.00)	0.844 (1.00)
EMG1	7 (1%)	789					0.107 (0.665)	0.203 (0.896)	0.0526 (0.43)	0.0553 (0.436)	0.164 (0.843)	0.287 (1.00)	0.894 (1.00)	0.382 (1.00)
ZNF709	7 (1%)	789			0.342 (1.00)	0.79 (1.00)	1 (1.00)	1 (1.00)	0.863 (1.00)	0.867 (1.00)	1 (1.00)	0.683 (1.00)	0.271 (0.998)	1 (1.00)
IRS4	10 (1%)	786	0.114 (0.692)	1 (1.00)	0.0528 (0.43)	0.122 (0.714)	0.773 (1.00)	0.696 (1.00)	0.671 (1.00)	0.237 (0.955)	0.415 (1.00)	0.691 (1.00)	0.271 (0.998)	1 (1.00)
TNRC18	12 (2%)	784					0.598 (1.00)	0.18 (0.887)	0.197 (0.896)	0.874 (1.00)	0.512 (1.00)	0.18 (0.887)	1 (1.00)	0.345 (1.00)
NRAS	5 (1%)	791					0.669 (1.00)	0.254 (0.987)	0.107 (0.665)	0.311 (1.00)	0.303 (1.00)	0.682 (1.00)	0.331 (1.00)	0.76 (1.00)
MX2	9 (1%)	787	0.598 (1.00)	0.841 (1.00)	0.443 (1.00)	0.442 (1.00)	0.365 (1.00)	0.717 (1.00)	1 (1.00)	1 (1.00)	0.367 (1.00)	1 (1.00)	1 (1.00)	0.639 (1.00)
DDX5	9 (1%)	787	0.217 (0.918)	1 (1.00)	0.537 (1.00)	0.445 (1.00)	1 (1.00)	0.675 (1.00)	0.878 (1.00)	0.592 (1.00)	0.264 (0.996)	0.443 (1.00)	0.0274 (0.288)	0.317 (1.00)
DNMT3A	10 (1%)	786					0.032 (0.32)	1 (1.00)	0.222 (0.924)	0.0859 (0.578)	0.48 (1.00)	0.0439 (0.398)	0.923 (1.00)	0.971 (1.00)
ZNF292	17 (2%)	779	0.476 (1.00)	0.224 (0.924)	0.397 (1.00)	0.31 (1.00)	0.252 (0.986)	0.168 (0.855)	0.155 (0.83)	0.0853 (0.576)	0.426 (1.00)	0.29 (1.00)	0.083 (0.566)	0.0544 (0.435)
RBPJ	7 (1%)	789					0.107 (0.665)	0.0397 (0.372)	0.0267 (0.286)	0.142 (0.793)	0.332 (1.00)	0.0285 (0.294)	0.116 (0.694)	0.444 (1.00)
ARID2	13 (2%)	783					0.457 (1.00)	0.945 (1.00)	1 (1.00)	0.144 (0.8)	0.601 (1.00)	0.343 (1.00)	0.479 (1.00)	0.461 (1.00)
ANKRD36	7 (1%)	789					0.306 (1.00)	0.0921 (0.6)	0.408 (1.00)	0.31 (1.00)	0.738 (1.00)	1 (1.00)	0.895 (1.00)	0.948 (1.00)
SRPX	4 (1%)	792					0.649 (1.00)	0.281 (1.00)	0.558 (1.00)	0.57 (1.00)	0.274 (0.999)	0.197 (0.896)	0.394 (1.00)	0.0622 (0.465)
FAM83D	5 (1%)	791					0.402 (1.00)	0.474 (1.00)	0.841 (1.00)	0.824 (1.00)	1 (1.00)	0.0524 (0.43)	1 (1.00)	0.776 (1.00)
GAGE2D	5 (1%)	791					0.672 (1.00)	1 (1.00)	0.863 (1.00)	0.866 (1.00)	0.766 (1.00)	1 (1.00)	0.744 (1.00)	0.292 (1.00)
HDAC2	7 (1%)	789	1 (1.00)	0.184 (0.896)	0.459 (1.00)	0.194 (0.896)	1 (1.00)	0.166 (0.849)	0.599 (1.00)	0.886 (1.00)	0.217 (0.918)	0.682 (1.00)	0.162 (0.842)	0.162 (0.842)
TYRP1	6 (1%)	790					1 (1.00)	0.923 (1.00)	0.781 (1.00)	0.389 (1.00)	0.401 (1.00)	0.342 (1.00)	0.694 (1.00)	0.357 (1.00)
BCOR	22 (3%)	774	0.642 (1.00)	0.359 (1.00)	0.103 (0.652)	0.609 (1.00)	1 (1.00)	0.652 (1.00)	0.279 (1.00)	0.363 (1.00)	0.792 (1.00)	0.582 (1.00)	0.722 (1.00)	0.951 (1.00)
NEU2	8 (1%)	788	0.218 (0.918)	0.548 (1.00)	0.781 (1.00)	1 (1.00)	1 (1.00)	0.849 (1.00)	1 (1.00)	0.347 (1.00)	0.304 (1.00)	1 (1.00)	0.458 (1.00)	0.712 (1.00)
SERPING1	4 (1%)	792					0.651 (1.00)	0.802 (1.00)	0.296 (1.00)	0.634 (1.00)	0.678 (1.00)	0.6 (1.00)	0.412 (1.00)	0.586 (1.00)
HTRA2	5 (1%)	791					0.199 (0.896)	0.407 (1.00)	0.863 (1.00)	0.869 (1.00)	0.347 (1.00)	0.726 (1.00)	0.556 (1.00)	0.471 (1.00)
NKD2	4 (1%)	792					1 (1.00)	1 (1.00)	0.397 (1.00)	1 (1.00)	0.367 (1.00)	1 (1.00)	1 (1.00)	0.838 (1.00)
TPX2	7 (1%)	789					0.734 (1.00)	0.643 (1.00)	1 (1.00)	0.595 (1.00)	0.489 (1.00)	0.0718 (0.516)	0.167 (0.854)	0.317 (1.00)
ZNF512B	5 (1%)	791					0.2 (0.896)	0.85 (1.00)	0.864 (1.00)	0.338 (1.00)	1 (1.00)	1 (1.00)	0.456 (1.00)	0.243 (0.962)
SPTAN1	8 (1%)	788			1 (1.00)	0.791 (1.00)	1 (1.00)	0.609 (1.00)	1 (1.00)	0.591 (1.00)	0.764 (1.00)	0.527 (1.00)	0.455 (1.00)	1 (1.00)
THRA	5 (1%)	791					0.669 (1.00)	0.283 (1.00)	0.688 (1.00)	0.312 (1.00)	0.218 (0.918)	0.682 (1.00)	0.333 (1.00)	0.581 (1.00)
RGS3	8 (1%)	788					0.736 (1.00)	0.253 (0.986)	0.8 (1.00)	0.502 (1.00)	0.215 (0.916)	0.756 (1.00)	0.296 (1.00)	0.941 (1.00)
PROKR2	9 (1%)	787	0.601 (1.00)	0.731 (1.00)	0.716 (1.00)	0.183 (0.896)	0.0514 (0.43)	0.249 (0.976)	0.0927 (0.6)	0.0388 (0.369)	0.282 (1.00)	0.795 (1.00)	1 (1.00)	0.774 (1.00)
SLC6A14	7 (1%)	789	0.881 (1.00)	0.48 (1.00)	0.833 (1.00)	1 (1.00)	0.698 (1.00)	0.046 (0.405)	0.158 (0.838)	0.822 (1.00)
MST1	6 (1%)	790					0.695 (1.00)	0.801 (1.00)	0.536 (1.00)	0.619 (1.00)	0.593 (1.00)	0.342 (1.00)	0.837 (1.00)	0.525 (1.00)
MED9	3 (0%)	793					1 (1.00)	0.473 (1.00)	0.296 (1.00)	1 (1.00)	0.878 (1.00)	0.793 (1.00)	0.653 (1.00)	0.508 (1.00)
MATK	9 (1%)	787			0.125 (0.722)	1 (1.00)	0.536 (1.00)	0.786 (1.00)	0.799 (1.00)	0.432 (1.00)	0.433 (1.00)	0.867 (1.00)	0.45 (1.00)	0.413 (1.00)
KDR	13 (2%)	783	0.203 (0.896)	0.655 (1.00)	0.278 (1.00)	0.511 (1.00)	0.193 (0.896)	0.0368 (0.357)	0.1 (0.64)	0.671 (1.00)	0.263 (0.996)	0.0237 (0.263)	0.242 (0.962)	0.196 (0.896)
WRN	6 (1%)	790					0.45 (1.00)	0.0495 (0.422)	1 (1.00)	0.517 (1.00)	0.0561 (0.439)	1 (1.00)	0.0433 (0.396)	0.453 (1.00)
G6PC	7 (1%)	789					0.731 (1.00)	0.279 (1.00)	0.798 (1.00)	1 (1.00)	0.428 (1.00)	0.151 (0.821)	0.292 (1.00)	0.763 (1.00)
TMEM184A	3 (0%)	793					1 (1.00)	0.354 (1.00)	0.202 (0.896)	0.784 (1.00)	0.879 (1.00)	0.232 (0.947)	0.413 (1.00)	0.511 (1.00)
PDHA1	6 (1%)	790					1 (1.00)	0.546 (1.00)	0.878 (1.00)	0.884 (1.00)	0.928 (1.00)	0.848 (1.00)	0.531 (1.00)	0.398 (1.00)
TMEM229B	4 (1%)	792	0.622 (1.00)	0.415 (1.00)	0.393 (1.00)	0.604 (1.00)	0.186 (0.896)	0.0455 (0.404)
CD44	6 (1%)	790	0.701 (1.00)	0.265 (0.996)	0.289 (1.00)	0.79 (1.00)	0.695 (1.00)	1 (1.00)	0.202 (0.896)	0.632 (1.00)	0.68 (1.00)	0.233 (0.951)	0.207 (0.901)	1 (1.00)
POM121	6 (1%)	790					0.447 (1.00)	0.312 (1.00)	0.541 (1.00)	0.618 (1.00)	0.589 (1.00)	0.34 (1.00)	0.695 (1.00)	0.525 (1.00)
SLC6A3	12 (2%)	784	0.624 (1.00)	0.702 (1.00)	0.396 (1.00)	1 (1.00)	0.595 (1.00)	0.879 (1.00)	1 (1.00)	0.67 (1.00)	0.176 (0.871)	0.508 (1.00)	0.704 (1.00)	0.533 (1.00)
SMOC1	4 (1%)	792					1 (1.00)	0.193 (0.896)	1 (1.00)	0.694 (1.00)	0.599 (1.00)	1 (1.00)	0.651 (1.00)	0.185 (0.896)
SLFN11	5 (1%)	791					0.672 (1.00)	1 (1.00)	0.687 (1.00)	0.48 (1.00)	0.593 (1.00)	0.265 (0.996)	0.475 (1.00)	0.76 (1.00)
DLC1	9 (1%)	787	0.479 (1.00)	0.0597 (0.458)	0.457 (1.00)	0.196 (0.896)	0.523 (1.00)	0.425 (1.00)	0.298 (1.00)	0.25 (0.978)	0.891 (1.00)	0.152 (0.823)	0.782 (1.00)	0.136 (0.768)
PPL	9 (1%)	787	0.306 (1.00)	0.699 (1.00)	0.606 (1.00)	0.789 (1.00)	0.737 (1.00)	0.957 (1.00)	0.703 (1.00)	0.636 (1.00)	0.145 (0.8)	0.757 (1.00)	0.33 (1.00)	0.729 (1.00)
CMA1	3 (0%)	793					1 (1.00)	0.547 (1.00)
ANO1	9 (1%)	787	0.477 (1.00)	0.0581 (0.452)	1 (1.00)	0.791 (1.00)	0.366 (1.00)	0.28 (1.00)	0.577 (1.00)	0.887 (1.00)	0.732 (1.00)	0.215 (0.916)	0.685 (1.00)	0.64 (1.00)
PLXNA3	10 (1%)	786					0.391 (1.00)	0.35 (1.00)	0.44 (1.00)	0.609 (1.00)	0.35 (1.00)	0.228 (0.936)	0.483 (1.00)	0.875 (1.00)
NAP1L2	6 (1%)	790					1 (1.00)	0.659 (1.00)	0.864 (1.00)	0.867 (1.00)	1 (1.00)	0.832 (1.00)	1 (1.00)	1 (1.00)
PLCH2	6 (1%)	790					0.695 (1.00)	0.179 (0.887)	0.602 (1.00)	1 (1.00)	0.912 (1.00)	0.681 (1.00)	0.694 (1.00)	0.524 (1.00)
CD1D	4 (1%)	792	0.878 (1.00)	1 (1.00)	0.642 (1.00)	0.123 (0.719)	0.0548 (0.435)	0.047 (0.407)
UBR3	5 (1%)	791					0.668 (1.00)	0.346 (1.00)	0.0258 (0.281)	0.234 (0.952)	0.304 (1.00)	0.833 (1.00)	0.331 (1.00)	0.759 (1.00)
CNOT1	8 (1%)	788					0.321 (1.00)	0.824 (1.00)	0.826 (1.00)	0.0468 (0.407)	0.768 (1.00)	0.691 (1.00)	0.805 (1.00)	0.679 (1.00)
ESR2	6 (1%)	790	0.476 (1.00)	0.702 (1.00)	0.779 (1.00)	0.437 (1.00)	1 (1.00)	0.804 (1.00)	0.562 (1.00)	0.696 (1.00)	0.192 (0.896)	0.431 (1.00)	1 (1.00)	1 (1.00)
TNFRSF9	4 (1%)	792					0.652 (1.00)	0.0648 (0.481)	1 (1.00)	1 (1.00)	0.6 (1.00)	0.795 (1.00)	0.651 (1.00)	0.514 (1.00)
CYP11A1	7 (1%)	789	0.783 (1.00)	0.89 (1.00)	0.875 (1.00)	0.313 (1.00)	1 (1.00)	0.663 (1.00)	0.0415 (0.384)	0.388 (1.00)	0.913 (1.00)	0.684 (1.00)	0.838 (1.00)	0.238 (0.955)
NCAPH2	4 (1%)	792					1 (1.00)	0.295 (1.00)	0.401 (1.00)	1 (1.00)
PRB3	3 (0%)	793					1 (1.00)	0.411 (1.00)	0.401 (1.00)	1 (1.00)
TRPV6	13 (2%)	783	0.335 (1.00)	0.228 (0.936)	0.189 (0.896)	1 (1.00)	0.45 (1.00)	0.677 (1.00)	0.0756 (0.527)	0.509 (1.00)	0.697 (1.00)	0.506 (1.00)	0.605 (1.00)	0.497 (1.00)
AOX1	8 (1%)	788	0.432 (1.00)	0.278 (1.00)	0.118 (0.701)	0.185 (0.896)	0.222 (0.924)	0.545 (1.00)	0.0915 (0.6)	0.105 (0.659)	0.0439 (0.398)	0.0277 (0.29)	0.27 (0.998)	0.919 (1.00)
EEF1A1	8 (1%)	788	0.397 (1.00)	0.193 (0.896)	0.536 (1.00)	0.445 (1.00)	0.125 (0.722)	0.47 (1.00)	0.222 (0.924)	0.442 (1.00)	0.0214 (0.251)	0.198 (0.896)	1 (1.00)	0.838 (1.00)
ZZZ3	4 (1%)	792					1 (1.00)	0.734 (1.00)	0.558 (1.00)	0.0726 (0.518)	0.382 (1.00)	0.432 (1.00)	0.65 (1.00)	0.887 (1.00)
PAK1	3 (0%)	793					1 (1.00)	0.545 (1.00)
WWC3	11 (1%)	785			0.605 (1.00)	0.123 (0.718)	1 (1.00)	0.957 (1.00)	0.916 (1.00)	0.635 (1.00)	0.738 (1.00)	1 (1.00)	0.804 (1.00)	0.241 (0.961)
TTC30B	7 (1%)	789					0.308 (1.00)	0.646 (1.00)	0.635 (1.00)	0.309 (1.00)	0.0746 (0.525)	0.666 (1.00)	0.453 (1.00)	0.392 (1.00)
ROBO3	5 (1%)	791					0.2 (0.896)	0.578 (1.00)	0.277 (1.00)	0.337 (1.00)	0.401 (1.00)	0.29 (1.00)	1 (1.00)	0.928 (1.00)
ST3GAL6	5 (1%)	791					0.401 (1.00)	0.296 (1.00)	0.0599 (0.458)	0.527 (1.00)	1 (1.00)	0.0523 (0.43)	0.413 (1.00)	0.15 (0.818)
CLCN7	7 (1%)	789	0.112 (0.684)	0.772 (1.00)	0.697 (1.00)	0.26 (0.996)	0.47 (1.00)	0.846 (1.00)	0.0737 (0.523)	0.39 (1.00)	0.679 (1.00)	0.793 (1.00)	0.204 (0.898)	0.671 (1.00)
CD99L2	5 (1%)	791					0.667 (1.00)	0.2 (0.896)	1 (1.00)	0.741 (1.00)	0.218 (0.918)	1 (1.00)	0.693 (1.00)	0.579 (1.00)
KRAS	4 (1%)	792					0.649 (1.00)	1 (1.00)	1 (1.00)	0.786 (1.00)
PRG4	10 (1%)	786					0.391 (1.00)	1 (1.00)	0.33 (1.00)	0.196 (0.896)	0.399 (1.00)	0.903 (1.00)	0.606 (1.00)	0.72 (1.00)
USP6	11 (1%)	785	0.93 (1.00)	1 (1.00)	0.404 (1.00)	0.43 (1.00)	0.408 (1.00)	0.694 (1.00)	0.169 (0.858)	0.492 (1.00)	0.73 (1.00)	0.219 (0.919)	1 (1.00)	0.551 (1.00)
TP63	9 (1%)	787	1 (1.00)	0.73 (1.00)	0.407 (1.00)	0.644 (1.00)	0.366 (1.00)	0.0616 (0.463)	0.0434 (0.396)	0.0568 (0.443)	0.238 (0.955)	0.429 (1.00)	0.0623 (0.465)	0.263 (0.996)
OR52M1	8 (1%)	788	0.505 (1.00)	0.603 (1.00)	0.0863 (0.579)	0.0593 (0.458)	0.224 (0.924)	0.379 (1.00)	0.574 (1.00)	0.271 (0.998)	0.765 (1.00)	1 (1.00)	1 (1.00)	0.839 (1.00)
TNFSF9	5 (1%)	791			0.683 (1.00)	0.308 (1.00)	0.402 (1.00)	0.473 (1.00)
HEATR3	4 (1%)	792					0.651 (1.00)	0.298 (1.00)	0.645 (1.00)	1 (1.00)
USP28	5 (1%)	791					0.402 (1.00)		0.157 (0.838)	0.822 (1.00)
RGL2	4 (1%)	792					0.329 (1.00)	1 (1.00)	1 (1.00)	0.14 (0.786)	0.401 (1.00)	0.339 (1.00)	0.695 (1.00)	0.582 (1.00)
MYO5A	5 (1%)	791					0.399 (1.00)	0.0373 (0.36)	0.158 (0.838)	0.823 (1.00)	0.765 (1.00)	0.344 (1.00)	0.472 (1.00)	0.527 (1.00)
DYNC1I1	10 (1%)	786	0.138 (0.774)	0.235 (0.953)	0.738 (1.00)	0.205 (0.901)	0.259 (0.996)	0.0722 (0.517)	0.537 (1.00)	0.618 (1.00)	1 (1.00)	0.796 (1.00)	0.412 (1.00)	0.589 (1.00)
PASD1	9 (1%)	787	1 (1.00)	0.702 (1.00)	0.52 (1.00)	0.0483 (0.414)	0.367 (1.00)	0.674 (1.00)	0.108 (0.665)	0.312 (1.00)	0.911 (1.00)	0.42 (1.00)	0.0778 (0.538)	0.762 (1.00)
RPL7	3 (0%)	793					0.575 (1.00)		0.0691 (0.503)	0.274 (0.999)
CES3	4 (1%)	792					1 (1.00)	1 (1.00)	0.296 (1.00)	0.634 (1.00)	0.446 (1.00)	1 (1.00)	0.207 (0.901)	1 (1.00)
CLEC12A	5 (1%)	791					0.399 (1.00)	0.224 (0.924)	0.54 (1.00)	0.619 (1.00)	0.081 (0.558)	0.342 (1.00)	0.693 (1.00)	0.918 (1.00)
CACNA1S	14 (2%)	782	0.525 (1.00)	0.769 (1.00)	0.597 (1.00)	1 (1.00)	0.147 (0.807)	0.289 (1.00)	0.112 (0.684)	0.407 (1.00)	0.415 (1.00)	0.691 (1.00)	0.355 (1.00)	0.266 (0.996)
SON	9 (1%)	787					0.537 (1.00)	0.511 (1.00)	0.839 (1.00)	0.841 (1.00)	0.827 (1.00)	0.517 (1.00)	0.641 (1.00)	0.156 (0.836)
SLC35A2	3 (0%)	793					1 (1.00)		1 (1.00)	1 (1.00)
OR2A12	7 (1%)	789			0.397 (1.00)	0.79 (1.00)	1 (1.00)	0.922 (1.00)	1 (1.00)	0.695 (1.00)	0.327 (1.00)	0.791 (1.00)	1 (1.00)	0.667 (1.00)
PLCG2	11 (1%)	785			0.53 (1.00)	1 (1.00)	0.41 (1.00)	0.0357 (0.35)	0.403 (1.00)	0.736 (1.00)	0.254 (0.987)	0.0225 (0.257)	0.501 (1.00)	0.0949 (0.61)
HTT	5 (1%)	791					0.201 (0.896)	0.0482 (0.414)	0.17 (0.86)	0.341 (1.00)	0.263 (0.996)	0.0237 (0.263)	0.455 (1.00)	0.71 (1.00)
MAP3K1	9 (1%)	787	1 (1.00)	0.728 (1.00)	0.807 (1.00)	0.646 (1.00)	0.162 (0.842)	0.546 (1.00)	0.163 (0.842)	0.271 (0.998)	0.327 (1.00)	0.0526 (0.43)	0.206 (0.901)	1 (1.00)
CSNK2B	3 (0%)	793					1 (1.00)	0.298 (1.00)
CCDC110	7 (1%)	789					0.732 (1.00)	0.505 (1.00)	0.558 (1.00)	0.695 (1.00)	0.0948 (0.61)	0.197 (0.896)	0.397 (1.00)	0.124 (0.719)
CD72	3 (0%)	793					0.0271 (0.286)	0.732 (1.00)	0.646 (1.00)	0.195 (0.896)	0.191 (0.896)	0.154 (0.829)	0.112 (0.684)	0.0279 (0.29)
SPINT1	6 (1%)	790	0.549 (1.00)	0.304 (1.00)	0.118 (0.701)	0.812 (1.00)	0.696 (1.00)	0.392 (1.00)	0.202 (0.896)	1 (1.00)
MORN5	3 (0%)	793					0.574 (1.00)
EGR1	5 (1%)	791	0.7 (1.00)	0.785 (1.00)	0.241 (0.961)	0.194 (0.896)	1 (1.00)		0.159 (0.838)	0.823 (1.00)
OR2A25	6 (1%)	790					0.696 (1.00)	0.925 (1.00)	0.744 (1.00)	1 (1.00)	0.442 (1.00)	0.683 (1.00)	0.476 (1.00)	0.524 (1.00)
PDGFRB	4 (1%)	792			0.125 (0.722)	0.436 (1.00)	0.0549 (0.435)	0.045 (0.402)	0.0664 (0.489)	0.0513 (0.43)
BTNL2	4 (1%)	792					1 (1.00)		1 (1.00)	1 (1.00)
RPTN	8 (1%)	788	0.783 (1.00)	0.891 (1.00)	0.916 (1.00)	0.812 (1.00)	0.471 (1.00)	0.249 (0.976)	0.54 (1.00)	0.0894 (0.591)	0.763 (1.00)	0.343 (1.00)	0.272 (0.998)	0.837 (1.00)
ZNF148	5 (1%)	791					0.199 (0.896)	0.168 (0.854)	1 (1.00)	0.739 (1.00)	0.59 (1.00)	0.263 (0.996)	0.697 (1.00)	0.758 (1.00)
GFRA4	3 (0%)	793					0.569 (1.00)	0.547 (1.00)
SLC6A4	6 (1%)	790					1 (1.00)	0.509 (1.00)	0.878 (1.00)	0.16 (0.842)	0.929 (1.00)	0.847 (1.00)	0.87 (1.00)	0.214 (0.913)
CCDC135	8 (1%)	788					0.0955 (0.612)	0.713 (1.00)	0.8 (1.00)	0.144 (0.8)	0.656 (1.00)	1 (1.00)	0.806 (1.00)	0.736 (1.00)
RUVBL2	4 (1%)	792					0.186 (0.896)
PYGL	4 (1%)	792					1 (1.00)	1 (1.00)	0.84 (1.00)	1 (1.00)	0.523 (1.00)	0.793 (1.00)	0.208 (0.902)	1 (1.00)
ASXL2	3 (0%)	793					0.309 (1.00)	0.351 (1.00)	1 (1.00)	0.634 (1.00)	0.525 (1.00)	0.791 (1.00)	0.208 (0.901)	1 (1.00)
CIB1	5 (1%)	791					0.672 (1.00)	1 (1.00)	0.689 (1.00)	0.312 (1.00)	0.217 (0.918)	0.0444 (0.401)	0.118 (0.701)	0.323 (1.00)
REXO1	8 (1%)	788			0.0526 (0.43)	0.0718 (0.516)	0.221 (0.924)	0.023 (0.259)	0.54 (1.00)	1 (1.00)	0.913 (1.00)	0.339 (1.00)	0.695 (1.00)	0.357 (1.00)
GLYAT	5 (1%)	791					0.668 (1.00)	0.923 (1.00)	0.388 (1.00)	0.401 (1.00)	0.193 (0.896)	0.266 (0.996)	0.837 (1.00)	0.697 (1.00)
EPS8L1	5 (1%)	791					1 (1.00)	0.546 (1.00)	0.842 (1.00)	0.696 (1.00)	0.679 (1.00)	0.797 (1.00)	0.413 (1.00)	0.588 (1.00)
CNOT4	6 (1%)	790					0.447 (1.00)	0.778 (1.00)	1 (1.00)	0.191 (0.896)	0.117 (0.699)	0.116 (0.694)	0.333 (1.00)	0.454 (1.00)
MYH8	21 (3%)	775	0.867 (1.00)	0.73 (1.00)	0.307 (1.00)	0.0868 (0.581)	0.48 (1.00)	0.199 (0.896)	0.263 (0.996)	0.426 (1.00)	0.854 (1.00)	0.252 (0.984)	0.839 (1.00)	0.773 (1.00)
DPYS	5 (1%)	791					0.669 (1.00)	0.661 (1.00)	0.687 (1.00)	0.311 (1.00)	1 (1.00)	0.424 (1.00)	0.12 (0.705)	0.637 (1.00)
TLR7	10 (1%)	786	0.173 (0.871)	0.482 (1.00)	0.762 (1.00)	0.674 (1.00)	0.558 (1.00)	0.128 (0.733)	0.675 (1.00)	0.736 (1.00)	1 (1.00)	0.757 (1.00)	0.294 (1.00)	0.352 (1.00)
MYH11	14 (2%)	782	1 (1.00)	0.478 (1.00)	0.0741 (0.524)	0.513 (1.00)	0.809 (1.00)	0.936 (1.00)	0.925 (1.00)	0.613 (1.00)	1 (1.00)	0.614 (1.00)	0.586 (1.00)	0.605 (1.00)
SLC9A4	11 (1%)	785	0.097 (0.62)	0.73 (1.00)	0.406 (1.00)	0.75 (1.00)	0.777 (1.00)	0.609 (1.00)	0.116 (0.694)	0.248 (0.976)	0.274 (0.999)	0.265 (0.996)	0.304 (1.00)	0.671 (1.00)
PAN3	7 (1%)	789	0.563 (1.00)	0.303 (1.00)	0.597 (1.00)	0.649 (1.00)	0.47 (1.00)		0.399 (1.00)	0.487 (1.00)
KRT15	8 (1%)	788					0.737 (1.00)	0.482 (1.00)	0.46 (1.00)	1 (1.00)	0.518 (1.00)	0.868 (1.00)	1 (1.00)	1 (1.00)
PPP2R5E	3 (0%)	793					1 (1.00)
DST	16 (2%)	780	0.835 (1.00)	1 (1.00)	0.181 (0.887)	0.813 (1.00)	0.821 (1.00)	0.726 (1.00)	0.905 (1.00)	1 (1.00)	0.416 (1.00)	0.934 (1.00)	0.411 (1.00)	0.273 (0.999)
CTBP2	3 (0%)	793					0.576 (1.00)
SSTR4	11 (1%)	785	0.599 (1.00)	0.713 (1.00)	0.445 (1.00)	0.259 (0.996)	0.779 (1.00)	0.437 (1.00)	0.229 (0.939)	0.494 (1.00)	0.768 (1.00)	0.332 (1.00)	0.642 (1.00)	0.873 (1.00)
SMARCB1	4 (1%)	792					0.328 (1.00)	1 (1.00)	0.686 (1.00)	0.145 (0.8)	0.44 (1.00)	0.682 (1.00)	0.0768 (0.533)	0.396 (1.00)
CAPN11	5 (1%)	791					1 (1.00)	0.734 (1.00)	0.843 (1.00)	0.48 (1.00)	0.523 (1.00)	0.793 (1.00)	0.207 (0.901)	1 (1.00)
SH3KBP1	4 (1%)	792					0.332 (1.00)	0.135 (0.762)	0.688 (1.00)	0.314 (1.00)	0.644 (1.00)	0.682 (1.00)	0.332 (1.00)	0.578 (1.00)

'IDH1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.00011 (Fisher's exact test), Q value = 0.0033

Table S1. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
IDH1 MUTATED	1	3	0	9
IDH1 WILD-TYPE	68	40	74	45

Figure S1. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

'IDH1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S2. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
IDH1 MUTATED	0	13	0	0
IDH1 WILD-TYPE	63	37	48	79

Figure S2. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

'IDH1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S3. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
IDH1 MUTATED	0	13	1	0
IDH1 WILD-TYPE	77	80	44	60

Figure S3. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

'IDH1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.003 (Fisher's exact test), Q value = 0.056

Table S4. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
IDH1 MUTATED	13	0	1
IDH1 WILD-TYPE	125	61	75

Figure S4. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

'IDH1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S5. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
IDH1 MUTATED	4	403	2
IDH1 WILD-TYPE	291	78	5

Figure S5. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'IDH1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S6. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
IDH1 MUTATED	0	228	22	153
IDH1 WILD-TYPE	160	4	42	13

Figure S6. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'IDH1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S7. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
IDH1 MUTATED	27	228	151
IDH1 WILD-TYPE	200	7	41

Figure S7. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'IDH1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S8. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
IDH1 MUTATED	1	181	224
IDH1 WILD-TYPE	195	9	44

Figure S8. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'IDH1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 5e-05 (Fisher's exact test), Q value = 0.0016

Table S9. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
IDH1 MUTATED	97	73	146	78
IDH1 WILD-TYPE	39	34	37	5

Figure S9. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'IDH1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S10. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
IDH1 MUTATED	207	152	35
IDH1 WILD-TYPE	15	32	68

Figure S10. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'IDH1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S11. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
IDH1 MUTATED	114	153	124
IDH1 WILD-TYPE	70	9	35

Figure S11. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'IDH1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S12. Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
IDH1 MUTATED	84	129	161	17
IDH1 WILD-TYPE	6	9	27	72

Figure S12. Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'TP53 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.00065 (Fisher's exact test), Q value = 0.016

Table S13. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
TP53 MUTATED	16	19	11	22
TP53 WILD-TYPE	53	24	63	32

Figure S13. Get High-res Image Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

'TP53 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S14. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
TP53 MUTATED	15	30	7	16
TP53 WILD-TYPE	48	20	41	63

Figure S14. Get High-res Image Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

'TP53 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.00156 (Fisher's exact test), Q value = 0.034

Table S15. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
TP53 MUTATED	12	39	10	18
TP53 WILD-TYPE	65	54	35	42

Figure S15. Get High-res Image Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

'TP53 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.149 (Fisher's exact test), Q value = 0.81

Table S16. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
TP53 MUTATED	47	15	17
TP53 WILD-TYPE	91	46	59

'TP53 MUTATION STATUS' versus 'CN_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S17. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TP53 MUTATED	67	255	4
TP53 WILD-TYPE	228	226	3

Figure S16. Get High-res Image Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'TP53 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S18. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TP53 MUTATED	33	221	12	8
TP53 WILD-TYPE	127	11	52	158

Figure S17. Get High-res Image Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'TP53 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S19. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TP53 MUTATED	70	155	67
TP53 WILD-TYPE	157	80	125

Figure S18. Get High-res Image Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'TP53 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S20. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TP53 MUTATED	43	176	73
TP53 WILD-TYPE	153	14	195

Figure S19. Get High-res Image Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'TP53 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S21. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TP53 MUTATED	82	70	74	18
TP53 WILD-TYPE	54	37	109	65

Figure S20. Get High-res Image Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'TP53 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S22. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TP53 MUTATED	133	71	40
TP53 WILD-TYPE	89	113	63

Figure S21. Get High-res Image Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'TP53 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0536 (Fisher's exact test), Q value = 0.43

Table S23. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TP53 MUTATED	98	79	64
TP53 WILD-TYPE	86	83	95

'TP53 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S24. Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TP53 MUTATED	79	56	85	21
TP53 WILD-TYPE	11	82	103	68

Figure S22. Get High-res Image Gene #2: 'TP53 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'ATRX MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.00209 (Fisher's exact test), Q value = 0.041

Table S25. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
ATRX MUTATED	2	4	0	7
ATRX WILD-TYPE	67	39	74	47

Figure S23. Get High-res Image Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

'ATRX MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S26. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
ATRX MUTATED	0	11	0	2
ATRX WILD-TYPE	63	39	48	77

Figure S24. Get High-res Image Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

'ATRX MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.00659 (Fisher's exact test), Q value = 0.11

Table S27. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
ATRX MUTATED	2	11	3	0
ATRX WILD-TYPE	75	82	42	60

Figure S25. Get High-res Image Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

'ATRX MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.0179 (Fisher's exact test), Q value = 0.22

Table S28. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
ATRX MUTATED	13	0	3
ATRX WILD-TYPE	125	61	73

Figure S26. Get High-res Image Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

'ATRX MUTATION STATUS' versus 'CN_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S29. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ATRX MUTATED	5	204	1
ATRX WILD-TYPE	290	277	6

Figure S27. Get High-res Image Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'ATRX MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S30. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ATRX MUTATED	6	178	14	4
ATRX WILD-TYPE	154	54	50	162

Figure S28. Get High-res Image Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'ATRX MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S31. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ATRX MUTATED	25	123	55
ATRX WILD-TYPE	202	112	137

Figure S29. Get High-res Image Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'ATRX MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S32. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ATRX MUTATED	5	140	58
ATRX WILD-TYPE	191	50	210

Figure S30. Get High-res Image Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'ATRX MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S33. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ATRX MUTATED	60	60	59	12
ATRX WILD-TYPE	76	47	124	71

Figure S31. Get High-res Image Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'ATRX MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 3e-05 (Fisher's exact test), Q value = 0.001

Table S34. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ATRX MUTATED	108	58	25
ATRX WILD-TYPE	114	126	78

Figure S32. Get High-res Image Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'ATRX MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.259 (Fisher's exact test), Q value = 1

Table S35. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ATRX MUTATED	76	60	52
ATRX WILD-TYPE	108	102	107

'ATRX MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S36. Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ATRX MUTATED	62	43	69	14
ATRX WILD-TYPE	28	95	119	75

Figure S33. Get High-res Image Gene #3: 'ATRX MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'PTEN MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.115 (Fisher's exact test), Q value = 0.69

Table S37. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
PTEN MUTATED	25	10	18	22
PTEN WILD-TYPE	44	33	56	32

'PTEN MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0756 (Fisher's exact test), Q value = 0.53

Table S38. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
PTEN MUTATED	18	16	9	32
PTEN WILD-TYPE	45	34	39	47

'PTEN MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.0264 (Fisher's exact test), Q value = 0.28

Table S39. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PTEN MUTATED	30	19	18	20
PTEN WILD-TYPE	47	74	27	40

Figure S34. Get High-res Image Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

'PTEN MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.642 (Fisher's exact test), Q value = 1

Table S40. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PTEN MUTATED	45	21	21
PTEN WILD-TYPE	93	40	55

'PTEN MUTATION STATUS' versus 'CN_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S41. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PTEN MUTATED	91	16	2
PTEN WILD-TYPE	204	465	5

Figure S35. Get High-res Image Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'PTEN MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S42. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PTEN MUTATED	47	3	6	1
PTEN WILD-TYPE	113	229	58	165

Figure S36. Get High-res Image Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'PTEN MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S43. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PTEN MUTATED	62	4	3
PTEN WILD-TYPE	165	231	189

Figure S37. Get High-res Image Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'PTEN MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S44. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PTEN MUTATED	61	4	4
PTEN WILD-TYPE	135	186	264

Figure S38. Get High-res Image Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'PTEN MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0034 (Fisher's exact test), Q value = 0.062

Table S45. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PTEN MUTATED	12	8	3	1
PTEN WILD-TYPE	124	99	180	82

Figure S39. Get High-res Image Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'PTEN MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S46. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PTEN MUTATED	6	1	17
PTEN WILD-TYPE	216	183	86

Figure S40. Get High-res Image Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'PTEN MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S47. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PTEN MUTATED	20	2	2
PTEN WILD-TYPE	164	160	157

Figure S41. Get High-res Image Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'PTEN MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S48. Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PTEN MUTATED	3	3	1	17
PTEN WILD-TYPE	87	135	187	72

Figure S42. Get High-res Image Gene #4: 'PTEN MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'CIC MUTATION STATUS' versus 'CN_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S49. Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CIC MUTATED	0	109	0
CIC WILD-TYPE	295	372	7

Figure S43. Get High-res Image Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'CIC MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S50. Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CIC MUTATED	1	0	4	103
CIC WILD-TYPE	159	232	60	63

Figure S44. Get High-res Image Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'CIC MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S51. Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CIC MUTATED	2	55	52
CIC WILD-TYPE	225	180	140

Figure S45. Get High-res Image Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'CIC MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S52. Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CIC MUTATED	0	5	104
CIC WILD-TYPE	196	185	164

Figure S46. Get High-res Image Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'CIC MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S53. Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CIC MUTATED	15	4	43	46
CIC WILD-TYPE	121	103	140	37

Figure S47. Get High-res Image Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'CIC MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S54. Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CIC MUTATED	55	51	2
CIC WILD-TYPE	167	133	101

Figure S48. Get High-res Image Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'CIC MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S55. Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CIC MUTATED	11	61	36
CIC WILD-TYPE	173	101	123

Figure S49. Get High-res Image Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'CIC MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S56. Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CIC MUTATED	2	62	43	1
CIC WILD-TYPE	88	76	145	88

Figure S50. Get High-res Image Gene #5: 'CIC MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'PIK3CA MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.792 (Fisher's exact test), Q value = 1

Table S57. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
PIK3CA MUTATED	6	6	9	5
PIK3CA WILD-TYPE	63	37	65	49

'PIK3CA MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.164 (Fisher's exact test), Q value = 0.84

Table S58. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
PIK3CA MUTATED	8	6	8	4
PIK3CA WILD-TYPE	55	44	40	75

'PIK3CA MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.574 (Fisher's exact test), Q value = 1

Table S59. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PIK3CA MUTATED	9	11	2	6
PIK3CA WILD-TYPE	68	82	43	54

'PIK3CA MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S60. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PIK3CA MUTATED	14	6	8
PIK3CA WILD-TYPE	124	55	68

'PIK3CA MUTATION STATUS' versus 'CN_CNMF'

P value = 0.601 (Fisher's exact test), Q value = 1

Table S61. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PIK3CA MUTATED	28	42	1
PIK3CA WILD-TYPE	267	439	6

'PIK3CA MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S62. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PIK3CA MUTATED	21	6	3	27
PIK3CA WILD-TYPE	139	226	61	139

Figure S51. Get High-res Image Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'PIK3CA MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.347 (Fisher's exact test), Q value = 1

Table S63. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PIK3CA MUTATED	24	16	15
PIK3CA WILD-TYPE	203	219	177

'PIK3CA MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0329 (Fisher's exact test), Q value = 0.33

Table S64. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PIK3CA MUTATED	19	8	28
PIK3CA WILD-TYPE	177	182	240

Figure S52. Get High-res Image Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'PIK3CA MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.00963 (Fisher's exact test), Q value = 0.14

Table S65. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PIK3CA MUTATED	5	14	13	12
PIK3CA WILD-TYPE	131	93	170	71

Figure S53. Get High-res Image Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'PIK3CA MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0398 (Fisher's exact test), Q value = 0.37

Table S66. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PIK3CA MUTATED	13	16	15
PIK3CA WILD-TYPE	209	168	88

Figure S54. Get High-res Image Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'PIK3CA MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.327 (Fisher's exact test), Q value = 1

Table S67. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PIK3CA MUTATED	17	10	17
PIK3CA WILD-TYPE	167	152	142

'PIK3CA MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.00088 (Fisher's exact test), Q value = 0.021

Table S68. Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PIK3CA MUTATED	0	15	17	12
PIK3CA WILD-TYPE	90	123	171	77

Figure S55. Get High-res Image Gene #6: 'PIK3CA MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'NF1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.0812 (Fisher's exact test), Q value = 0.56

Table S69. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
NF1 MUTATED	11	4	4	2
NF1 WILD-TYPE	58	39	70	52

'NF1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.00027 (Fisher's exact test), Q value = 0.0071

Table S70. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
NF1 MUTATED	14	1	1	5
NF1 WILD-TYPE	49	49	47	74

Figure S56. Get High-res Image Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

'NF1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.0252 (Fisher's exact test), Q value = 0.28

Table S71. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
NF1 MUTATED	12	3	5	8
NF1 WILD-TYPE	65	90	40	52

Figure S57. Get High-res Image Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

'NF1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.933 (Fisher's exact test), Q value = 1

Table S72. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
NF1 MUTATED	14	7	7
NF1 WILD-TYPE	124	54	69

'NF1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00264 (Fisher's exact test), Q value = 0.051

Table S73. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
NF1 MUTATED	33	27	2
NF1 WILD-TYPE	262	454	5

Figure S58. Get High-res Image Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'NF1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S74. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
NF1 MUTATED	24	2	13	7
NF1 WILD-TYPE	136	230	51	159

Figure S59. Get High-res Image Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'NF1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.00012 (Fisher's exact test), Q value = 0.0035

Table S75. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
NF1 MUTATED	28	6	10
NF1 WILD-TYPE	199	229	182

Figure S60. Get High-res Image Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'NF1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00177 (Fisher's exact test), Q value = 0.036

Table S76. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
NF1 MUTATED	24	7	13
NF1 WILD-TYPE	172	183	255

Figure S61. Get High-res Image Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'NF1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.337 (Fisher's exact test), Q value = 1

Table S77. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
NF1 MUTATED	9	11	9	4
NF1 WILD-TYPE	127	96	174	79

'NF1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.00012 (Fisher's exact test), Q value = 0.0035

Table S78. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
NF1 MUTATED	10	6	17
NF1 WILD-TYPE	212	178	86

Figure S62. Get High-res Image Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'NF1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.00548 (Fisher's exact test), Q value = 0.094

Table S79. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
NF1 MUTATED	21	6	6
NF1 WILD-TYPE	163	156	153

Figure S63. Get High-res Image Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'NF1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S80. Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
NF1 MUTATED	1	6	7	19
NF1 WILD-TYPE	89	132	181	70

Figure S64. Get High-res Image Gene #7: 'NF1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'PIK3R1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.749 (Fisher's exact test), Q value = 1

Table S81. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
PIK3R1 MUTATED	7	2	8	5
PIK3R1 WILD-TYPE	62	41	66	49

'PIK3R1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.192 (Fisher's exact test), Q value = 0.9

Table S82. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
PIK3R1 MUTATED	7	6	6	3
PIK3R1 WILD-TYPE	56	44	42	76

'PIK3R1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.2 (Fisher's exact test), Q value = 0.9

Table S83. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PIK3R1 MUTATED	12	13	4	3
PIK3R1 WILD-TYPE	65	80	41	57

'PIK3R1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.53 (Fisher's exact test), Q value = 1

Table S84. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PIK3R1 MUTATED	16	5	11
PIK3R1 WILD-TYPE	122	56	65

'PIK3R1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0172 (Fisher's exact test), Q value = 0.21

Table S85. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PIK3R1 MUTATED	26	25	2
PIK3R1 WILD-TYPE	269	456	5

Figure S65. Get High-res Image Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'PIK3R1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-04 (Fisher's exact test), Q value = 0.003

Table S86. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PIK3R1 MUTATED	21	5	1	13
PIK3R1 WILD-TYPE	139	227	63	153

Figure S66. Get High-res Image Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'PIK3R1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.249 (Fisher's exact test), Q value = 0.98

Table S87. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PIK3R1 MUTATED	15	13	6
PIK3R1 WILD-TYPE	212	222	186

'PIK3R1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.927 (Fisher's exact test), Q value = 1

Table S88. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PIK3R1 MUTATED	11	10	13
PIK3R1 WILD-TYPE	185	180	255

'PIK3R1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0882 (Fisher's exact test), Q value = 0.59

Table S89. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PIK3R1 MUTATED	6	3	5	8
PIK3R1 WILD-TYPE	130	104	178	75

'PIK3R1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.585 (Fisher's exact test), Q value = 1

Table S90. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PIK3R1 MUTATED	12	7	3
PIK3R1 WILD-TYPE	210	177	100

'PIK3R1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.962 (Fisher's exact test), Q value = 1

Table S91. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PIK3R1 MUTATED	9	7	6
PIK3R1 WILD-TYPE	175	155	153

'PIK3R1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.63 (Fisher's exact test), Q value = 1

Table S92. Gene #8: 'PIK3R1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PIK3R1 MUTATED	3	8	9	2
PIK3R1 WILD-TYPE	87	130	179	87

'NOTCH1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S93. Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
NOTCH1 MUTATED	0	42	0
NOTCH1 WILD-TYPE	295	439	7

Figure S67. Get High-res Image Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'NOTCH1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S94. Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
NOTCH1 MUTATED	1	9	0	32
NOTCH1 WILD-TYPE	159	223	64	134

Figure S68. Get High-res Image Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'NOTCH1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S95. Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
NOTCH1 MUTATED	1	16	25
NOTCH1 WILD-TYPE	226	219	167

Figure S69. Get High-res Image Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'NOTCH1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S96. Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
NOTCH1 MUTATED	0	6	36
NOTCH1 WILD-TYPE	196	184	232

Figure S70. Get High-res Image Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'NOTCH1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.00021 (Fisher's exact test), Q value = 0.0057

Table S97. Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
NOTCH1 MUTATED	4	3	21	13
NOTCH1 WILD-TYPE	132	104	162	70

Figure S71. Get High-res Image Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'NOTCH1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0042 (Fisher's exact test), Q value = 0.076

Table S98. Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
NOTCH1 MUTATED	16	23	2
NOTCH1 WILD-TYPE	206	161	101

Figure S72. Get High-res Image Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'NOTCH1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.00168 (Fisher's exact test), Q value = 0.035

Table S99. Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
NOTCH1 MUTATED	6	13	22
NOTCH1 WILD-TYPE	178	149	137

Figure S73. Get High-res Image Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'NOTCH1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.00015 (Fisher's exact test), Q value = 0.0042

Table S100. Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
NOTCH1 MUTATED	3	14	24	0
NOTCH1 WILD-TYPE	87	124	164	89

Figure S74. Get High-res Image Gene #9: 'NOTCH1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'FUBP1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S101. Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
FUBP1 MUTATED	0	47	0
FUBP1 WILD-TYPE	295	434	7

Figure S75. Get High-res Image Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'FUBP1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S102. Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
FUBP1 MUTATED	1	0	0	46
FUBP1 WILD-TYPE	159	232	64	120

Figure S76. Get High-res Image Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'FUBP1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S103. Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
FUBP1 MUTATED	1	21	25
FUBP1 WILD-TYPE	226	214	167

Figure S77. Get High-res Image Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'FUBP1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S104. Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
FUBP1 MUTATED	0	3	44
FUBP1 WILD-TYPE	196	187	224

Figure S78. Get High-res Image Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'FUBP1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 2e-05 (Fisher's exact test), Q value = 0.00073

Table S105. Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
FUBP1 MUTATED	6	1	22	18
FUBP1 WILD-TYPE	130	106	161	65

Figure S79. Get High-res Image Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'FUBP1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0011 (Fisher's exact test), Q value = 0.025

Table S106. Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
FUBP1 MUTATED	24	22	1
FUBP1 WILD-TYPE	198	162	102

Figure S80. Get High-res Image Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'FUBP1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.00756 (Fisher's exact test), Q value = 0.12

Table S107. Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
FUBP1 MUTATED	8	22	17
FUBP1 WILD-TYPE	176	140	142

Figure S81. Get High-res Image Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'FUBP1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S108. Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
FUBP1 MUTATED	0	23	24	0
FUBP1 WILD-TYPE	90	115	164	89

Figure S82. Get High-res Image Gene #10: 'FUBP1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'RB1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.0339 (Fisher's exact test), Q value = 0.33

Table S109. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
RB1 MUTATED	11	2	3	2
RB1 WILD-TYPE	58	41	71	52

Figure S83. Get High-res Image Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

'RB1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0166 (Fisher's exact test), Q value = 0.21

Table S110. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
RB1 MUTATED	5	2	0	11
RB1 WILD-TYPE	58	48	48	68

Figure S84. Get High-res Image Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

'RB1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.133 (Fisher's exact test), Q value = 0.76

Table S111. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
RB1 MUTATED	11	4	3	6
RB1 WILD-TYPE	66	89	42	54

'RB1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.923 (Fisher's exact test), Q value = 1

Table S112. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
RB1 MUTATED	12	6	6
RB1 WILD-TYPE	126	55	70

'RB1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S113. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
RB1 MUTATED	27	2	1
RB1 WILD-TYPE	268	479	6

Figure S85. Get High-res Image Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'RB1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S114. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
RB1 MUTATED	12	0	1	1
RB1 WILD-TYPE	148	232	63	165

Figure S86. Get High-res Image Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'RB1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 6e-05 (Fisher's exact test), Q value = 0.0019

Table S115. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
RB1 MUTATED	14	1	1
RB1 WILD-TYPE	213	234	191

Figure S87. Get High-res Image Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'RB1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 5e-05 (Fisher's exact test), Q value = 0.0016

Table S116. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
RB1 MUTATED	13	1	2
RB1 WILD-TYPE	183	189	266

Figure S88. Get High-res Image Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'RB1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.599 (Fisher's exact test), Q value = 1

Table S117. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
RB1 MUTATED	3	1	1	1
RB1 WILD-TYPE	133	106	182	82

'RB1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.034 (Fisher's exact test), Q value = 0.33

Table S118. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
RB1 MUTATED	1	1	4
RB1 WILD-TYPE	221	183	99

Figure S89. Get High-res Image Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'RB1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.78 (Fisher's exact test), Q value = 1

Table S119. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
RB1 MUTATED	3	1	2
RB1 WILD-TYPE	181	161	157

'RB1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.248 (Fisher's exact test), Q value = 0.98

Table S120. Gene #11: 'RB1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
RB1 MUTATED	0	1	2	3
RB1 WILD-TYPE	90	137	186	86

'IDH2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00036 (Fisher's exact test), Q value = 0.0093

Table S121. Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
IDH2 MUTATED	0	20	0
IDH2 WILD-TYPE	295	461	7

Figure S90. Get High-res Image Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'IDH2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 6e-05 (Fisher's exact test), Q value = 0.0019

Table S122. Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
IDH2 MUTATED	0	3	4	13
IDH2 WILD-TYPE	160	229	60	153

Figure S91. Get High-res Image Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'IDH2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 3e-05 (Fisher's exact test), Q value = 0.001

Table S123. Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
IDH2 MUTATED	0	6	14
IDH2 WILD-TYPE	227	229	178

Figure S92. Get High-res Image Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'IDH2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S124. Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
IDH2 MUTATED	0	1	19
IDH2 WILD-TYPE	196	189	249

Figure S93. Get High-res Image Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'IDH2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0102 (Fisher's exact test), Q value = 0.15

Table S125. Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
IDH2 MUTATED	3	0	12	5
IDH2 WILD-TYPE	133	107	171	78

Figure S94. Get High-res Image Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'IDH2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.00065 (Fisher's exact test), Q value = 0.016

Table S126. Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
IDH2 MUTATED	5	15	0
IDH2 WILD-TYPE	217	169	103

Figure S95. Get High-res Image Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'IDH2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.00297 (Fisher's exact test), Q value = 0.056

Table S127. Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
IDH2 MUTATED	1	8	11
IDH2 WILD-TYPE	183	154	148

Figure S96. Get High-res Image Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'IDH2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0469 (Fisher's exact test), Q value = 0.41

Table S128. Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
IDH2 MUTATED	2	6	12	0
IDH2 WILD-TYPE	88	132	176	89

Figure S97. Get High-res Image Gene #12: 'IDH2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'TCF12 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S129. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
TCF12 MUTATED	1	0	1	1
TCF12 WILD-TYPE	68	43	73	53

'TCF12 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.482 (Fisher's exact test), Q value = 1

Table S130. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
TCF12 MUTATED	1	1	1	0
TCF12 WILD-TYPE	62	49	47	79

'TCF12 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.645 (Fisher's exact test), Q value = 1

Table S131. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
TCF12 MUTATED	2	2	0	0
TCF12 WILD-TYPE	75	91	45	60

'TCF12 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.259 (Fisher's exact test), Q value = 1

Table S132. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
TCF12 MUTATED	2	2	0
TCF12 WILD-TYPE	136	59	76

'TCF12 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.222 (Fisher's exact test), Q value = 0.92

Table S133. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TCF12 MUTATED	3	15	0
TCF12 WILD-TYPE	292	466	7

'TCF12 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.793 (Fisher's exact test), Q value = 1

Table S134. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TCF12 MUTATED	3	7	1	6
TCF12 WILD-TYPE	157	225	63	160

'TCF12 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.129 (Fisher's exact test), Q value = 0.74

Table S135. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TCF12 MUTATED	2	9	5
TCF12 WILD-TYPE	225	226	187

'TCF12 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.295 (Fisher's exact test), Q value = 1

Table S136. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TCF12 MUTATED	2	6	8
TCF12 WILD-TYPE	194	184	260

'TCF12 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.698 (Fisher's exact test), Q value = 1

Table S137. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TCF12 MUTATED	4	2	5	4
TCF12 WILD-TYPE	132	105	178	79

'TCF12 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.514 (Fisher's exact test), Q value = 1

Table S138. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TCF12 MUTATED	8	6	1
TCF12 WILD-TYPE	214	178	102

'TCF12 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S139. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TCF12 MUTATED	5	5	5
TCF12 WILD-TYPE	179	157	154

'TCF12 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.515 (Fisher's exact test), Q value = 1

Table S140. Gene #13: 'TCF12 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TCF12 MUTATED	4	3	7	1
TCF12 WILD-TYPE	86	135	181	88

'STK19 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.591 (Fisher's exact test), Q value = 1

Table S141. Gene #14: 'STK19 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
STK19 MUTATED	3	8	0
STK19 WILD-TYPE	292	473	7

'STK19 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.47 (Fisher's exact test), Q value = 1

Table S142. Gene #14: 'STK19 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
STK19 MUTATED	3	4	2	1
STK19 WILD-TYPE	157	228	62	165

'STK19 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.352 (Fisher's exact test), Q value = 1

Table S143. Gene #14: 'STK19 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
STK19 MUTATED	4	2	5
STK19 WILD-TYPE	223	233	187

'STK19 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.861 (Fisher's exact test), Q value = 1

Table S144. Gene #14: 'STK19 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
STK19 MUTATED	3	4	4
STK19 WILD-TYPE	193	186	264

'STK19 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.17 (Fisher's exact test), Q value = 0.86

Table S145. Gene #14: 'STK19 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
STK19 MUTATED	1	4	5	0
STK19 WILD-TYPE	135	103	178	83

'STK19 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.543 (Fisher's exact test), Q value = 1

Table S146. Gene #14: 'STK19 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
STK19 MUTATED	3	4	3
STK19 WILD-TYPE	219	180	100

'STK19 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.921 (Fisher's exact test), Q value = 1

Table S147. Gene #14: 'STK19 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
STK19 MUTATED	3	4	3
STK19 WILD-TYPE	181	158	156

'STK19 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.844 (Fisher's exact test), Q value = 1

Table S148. Gene #14: 'STK19 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
STK19 MUTATED	1	2	5	2
STK19 WILD-TYPE	89	136	183	87

'ARID1A MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0206 (Fisher's exact test), Q value = 0.24

Table S149. Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ARID1A MUTATED	2	19	0
ARID1A WILD-TYPE	293	462	7

Figure S98. Get High-res Image Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'ARID1A MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0219 (Fisher's exact test), Q value = 0.25

Table S150. Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ARID1A MUTATED	2	6	1	12
ARID1A WILD-TYPE	158	226	63	154

Figure S99. Get High-res Image Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'ARID1A MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0252 (Fisher's exact test), Q value = 0.28

Table S151. Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ARID1A MUTATED	2	12	7
ARID1A WILD-TYPE	225	223	185

Figure S100. Get High-res Image Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'ARID1A MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00561 (Fisher's exact test), Q value = 0.094

Table S152. Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ARID1A MUTATED	1	5	15
ARID1A WILD-TYPE	195	185	253

Figure S101. Get High-res Image Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'ARID1A MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.313 (Fisher's exact test), Q value = 1

Table S153. Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ARID1A MUTATED	5	2	7	6
ARID1A WILD-TYPE	131	105	176	77

'ARID1A MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.605 (Fisher's exact test), Q value = 1

Table S154. Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ARID1A MUTATED	10	8	2
ARID1A WILD-TYPE	212	176	101

'ARID1A MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0848 (Fisher's exact test), Q value = 0.57

Table S155. Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ARID1A MUTATED	3	10	7
ARID1A WILD-TYPE	181	152	152

'ARID1A MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0298 (Fisher's exact test), Q value = 0.3

Table S156. Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ARID1A MUTATED	1	11	7	1
ARID1A WILD-TYPE	89	127	181	88

Figure S102. Get High-res Image Gene #15: 'ARID1A MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'NIPBL MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0283 (Fisher's exact test), Q value = 0.29

Table S157. Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
NIPBL MUTATED	2	18	0
NIPBL WILD-TYPE	293	463	7

Figure S103. Get High-res Image Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'NIPBL MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.00021 (Fisher's exact test), Q value = 0.0057

Table S158. Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
NIPBL MUTATED	3	2	0	14
NIPBL WILD-TYPE	157	230	64	152

Figure S104. Get High-res Image Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'NIPBL MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0532 (Fisher's exact test), Q value = 0.43

Table S159. Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
NIPBL MUTATED	3	12	4
NIPBL WILD-TYPE	224	223	188

'NIPBL MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0466 (Fisher's exact test), Q value = 0.41

Table S160. Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
NIPBL MUTATED	2	4	13
NIPBL WILD-TYPE	194	186	255

Figure S105. Get High-res Image Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'NIPBL MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.448 (Fisher's exact test), Q value = 1

Table S161. Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
NIPBL MUTATED	5	4	4	5
NIPBL WILD-TYPE	131	103	179	78

'NIPBL MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.175 (Fisher's exact test), Q value = 0.87

Table S162. Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
NIPBL MUTATED	12	4	2
NIPBL WILD-TYPE	210	180	101

'NIPBL MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0112 (Fisher's exact test), Q value = 0.16

Table S163. Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
NIPBL MUTATED	3	12	3
NIPBL WILD-TYPE	181	150	156

Figure S106. Get High-res Image Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'NIPBL MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0608 (Fisher's exact test), Q value = 0.46

Table S164. Gene #16: 'NIPBL MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
NIPBL MUTATED	3	10	4	1
NIPBL WILD-TYPE	87	128	184	88

'SMARCA4 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00174 (Fisher's exact test), Q value = 0.036

Table S165. Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SMARCA4 MUTATED	2	25	0
SMARCA4 WILD-TYPE	293	456	7

Figure S107. Get High-res Image Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'SMARCA4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0162 (Fisher's exact test), Q value = 0.21

Table S166. Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SMARCA4 MUTATED	3	17	0	7
SMARCA4 WILD-TYPE	157	215	64	159

Figure S108. Get High-res Image Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'SMARCA4 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.00545 (Fisher's exact test), Q value = 0.094

Table S167. Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SMARCA4 MUTATED	3	17	7
SMARCA4 WILD-TYPE	224	218	185

Figure S109. Get High-res Image Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'SMARCA4 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00991 (Fisher's exact test), Q value = 0.15

Table S168. Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SMARCA4 MUTATED	2	13	12
SMARCA4 WILD-TYPE	194	177	256

Figure S110. Get High-res Image Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'SMARCA4 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.306 (Fisher's exact test), Q value = 1

Table S169. Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SMARCA4 MUTATED	8	2	9	6
SMARCA4 WILD-TYPE	128	105	174	77

'SMARCA4 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.242 (Fisher's exact test), Q value = 0.96

Table S170. Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SMARCA4 MUTATED	14	9	2
SMARCA4 WILD-TYPE	208	175	101

'SMARCA4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.872 (Fisher's exact test), Q value = 1

Table S171. Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SMARCA4 MUTATED	8	9	8
SMARCA4 WILD-TYPE	176	153	151

'SMARCA4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.163 (Fisher's exact test), Q value = 0.84

Table S172. Gene #17: 'SMARCA4 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SMARCA4 MUTATED	7	6	11	1
SMARCA4 WILD-TYPE	83	132	177	88

'CREBZF MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0366 (Fisher's exact test), Q value = 0.36

Table S173. Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CREBZF MUTATED	0	9	0
CREBZF WILD-TYPE	295	472	7

Figure S111. Get High-res Image Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'CREBZF MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.00042 (Fisher's exact test), Q value = 0.011

Table S174. Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CREBZF MUTATED	0	0	0	7
CREBZF WILD-TYPE	160	232	64	159

Figure S112. Get High-res Image Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'CREBZF MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0215 (Fisher's exact test), Q value = 0.25

Table S175. Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CREBZF MUTATED	1	1	6
CREBZF WILD-TYPE	226	234	186

Figure S113. Get High-res Image Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'CREBZF MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0679 (Fisher's exact test), Q value = 0.5

Table S176. Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CREBZF MUTATED	0	2	6
CREBZF WILD-TYPE	196	188	262

'CREBZF MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.202 (Fisher's exact test), Q value = 0.9

Table S177. Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CREBZF MUTATED	0	1	5	1
CREBZF WILD-TYPE	136	106	178	82

'CREBZF MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0138 (Fisher's exact test), Q value = 0.18

Table S178. Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CREBZF MUTATED	0	6	1
CREBZF WILD-TYPE	222	178	102

Figure S114. Get High-res Image Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'CREBZF MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.114 (Fisher's exact test), Q value = 0.69

Table S179. Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CREBZF MUTATED	1	1	5
CREBZF WILD-TYPE	183	161	154

'CREBZF MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0532 (Fisher's exact test), Q value = 0.43

Table S180. Gene #18: 'CREBZF MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CREBZF MUTATED	0	0	6	1
CREBZF WILD-TYPE	90	138	182	88

'EMG1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.107 (Fisher's exact test), Q value = 0.67

Table S181. Gene #19: 'EMG1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
EMG1 MUTATED	0	7	0
EMG1 WILD-TYPE	295	474	7

'EMG1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.203 (Fisher's exact test), Q value = 0.9

Table S182. Gene #19: 'EMG1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
EMG1 MUTATED	0	3	0	4
EMG1 WILD-TYPE	160	229	64	162

'EMG1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0526 (Fisher's exact test), Q value = 0.43

Table S183. Gene #19: 'EMG1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
EMG1 MUTATED	0	5	2
EMG1 WILD-TYPE	227	230	190

'EMG1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0553 (Fisher's exact test), Q value = 0.44

Table S184. Gene #19: 'EMG1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
EMG1 MUTATED	0	1	6
EMG1 WILD-TYPE	196	189	262

'EMG1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.164 (Fisher's exact test), Q value = 0.84

Table S185. Gene #19: 'EMG1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
EMG1 MUTATED	1	0	3	3
EMG1 WILD-TYPE	135	107	180	80

'EMG1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.287 (Fisher's exact test), Q value = 1

Table S186. Gene #19: 'EMG1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
EMG1 MUTATED	5	2	0
EMG1 WILD-TYPE	217	182	103

'EMG1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.894 (Fisher's exact test), Q value = 1

Table S187. Gene #19: 'EMG1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
EMG1 MUTATED	2	3	2
EMG1 WILD-TYPE	182	159	157

'EMG1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.382 (Fisher's exact test), Q value = 1

Table S188. Gene #19: 'EMG1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
EMG1 MUTATED	1	4	2	0
EMG1 WILD-TYPE	89	134	186	89

'ZNF709 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.342 (Fisher's exact test), Q value = 1

Table S189. Gene #20: 'ZNF709 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
ZNF709 MUTATED	2	0	0	1
ZNF709 WILD-TYPE	75	93	45	59

'ZNF709 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.79 (Fisher's exact test), Q value = 1

Table S190. Gene #20: 'ZNF709 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
ZNF709 MUTATED	1	1	1
ZNF709 WILD-TYPE	137	60	75

'ZNF709 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S191. Gene #20: 'ZNF709 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ZNF709 MUTATED	3	4	0
ZNF709 WILD-TYPE	292	477	7

'ZNF709 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S192. Gene #20: 'ZNF709 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ZNF709 MUTATED	2	2	0	2
ZNF709 WILD-TYPE	158	230	64	164

'ZNF709 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.863 (Fisher's exact test), Q value = 1

Table S193. Gene #20: 'ZNF709 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ZNF709 MUTATED	1	2	2
ZNF709 WILD-TYPE	226	233	190

'ZNF709 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.867 (Fisher's exact test), Q value = 1

Table S194. Gene #20: 'ZNF709 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ZNF709 MUTATED	1	2	2
ZNF709 WILD-TYPE	195	188	266

'ZNF709 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S195. Gene #20: 'ZNF709 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ZNF709 MUTATED	1	1	2	0
ZNF709 WILD-TYPE	135	106	181	83

'ZNF709 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.683 (Fisher's exact test), Q value = 1

Table S196. Gene #20: 'ZNF709 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ZNF709 MUTATED	1	2	1
ZNF709 WILD-TYPE	221	182	102

'ZNF709 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.271 (Fisher's exact test), Q value = 1

Table S197. Gene #20: 'ZNF709 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ZNF709 MUTATED	3	0	1
ZNF709 WILD-TYPE	181	162	158

'ZNF709 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S198. Gene #20: 'ZNF709 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ZNF709 MUTATED	1	1	2	0
ZNF709 WILD-TYPE	89	137	186	89

'RPL5 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.383 (Fisher's exact test), Q value = 1

Table S199. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
RPL5 MUTATED	1	2	3	0
RPL5 WILD-TYPE	68	41	71	54

'RPL5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.51 (Fisher's exact test), Q value = 1

Table S200. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
RPL5 MUTATED	3	0	1	2
RPL5 WILD-TYPE	60	50	47	77

'RPL5 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.869 (Fisher's exact test), Q value = 1

Table S201. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
RPL5 MUTATED	1	3	1	2
RPL5 WILD-TYPE	76	90	44	58

'RPL5 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.467 (Fisher's exact test), Q value = 1

Table S202. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
RPL5 MUTATED	3	3	1
RPL5 WILD-TYPE	135	58	75

'RPL5 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.262 (Fisher's exact test), Q value = 1

Table S203. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
RPL5 MUTATED	6	4	0
RPL5 WILD-TYPE	289	477	7

'RPL5 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0138 (Fisher's exact test), Q value = 0.18

Table S204. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
RPL5 MUTATED	5	0	0	1
RPL5 WILD-TYPE	155	232	64	165

Figure S115. Get High-res Image Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'RPL5 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0223 (Fisher's exact test), Q value = 0.26

Table S205. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
RPL5 MUTATED	5	0	1
RPL5 WILD-TYPE	222	235	191

Figure S116. Get High-res Image Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'RPL5 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.189 (Fisher's exact test), Q value = 0.9

Table S206. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
RPL5 MUTATED	4	1	1
RPL5 WILD-TYPE	192	189	267

'RPL5 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0928 (Fisher's exact test), Q value = 0.6

Table S207. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
RPL5 MUTATED	0	2	0	1
RPL5 WILD-TYPE	136	105	183	82

'RPL5 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0518 (Fisher's exact test), Q value = 0.43

Table S208. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
RPL5 MUTATED	0	1	2
RPL5 WILD-TYPE	222	183	101

'RPL5 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S209. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
RPL5 MUTATED	1	1	1
RPL5 WILD-TYPE	183	161	158

'RPL5 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.511 (Fisher's exact test), Q value = 1

Table S210. Gene #21: 'RPL5 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
RPL5 MUTATED	0	0	2	1
RPL5 WILD-TYPE	90	138	186	88

'STAG2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.39 (Fisher's exact test), Q value = 1

Table S211. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
STAG2 MUTATED	4	3	1	2
STAG2 WILD-TYPE	65	40	73	52

'STAG2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.698 (Fisher's exact test), Q value = 1

Table S212. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
STAG2 MUTATED	2	1	3	4
STAG2 WILD-TYPE	61	49	45	75

'STAG2 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.714 (Fisher's exact test), Q value = 1

Table S213. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
STAG2 MUTATED	4	5	2	1
STAG2 WILD-TYPE	73	88	43	59

'STAG2 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.587 (Fisher's exact test), Q value = 1

Table S214. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
STAG2 MUTATED	5	2	5
STAG2 WILD-TYPE	133	59	71

'STAG2 MUTATION STATUS' versus 'CN_CNMF'

P value = 8e-05 (Fisher's exact test), Q value = 0.0025

Table S215. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
STAG2 MUTATED	13	2	1
STAG2 WILD-TYPE	282	479	6

Figure S117. Get High-res Image Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'STAG2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.00061 (Fisher's exact test), Q value = 0.015

Table S216. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
STAG2 MUTATED	8	1	0	0
STAG2 WILD-TYPE	152	231	64	166

Figure S118. Get High-res Image Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'STAG2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1e-04 (Fisher's exact test), Q value = 0.003

Table S217. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
STAG2 MUTATED	10	0	1
STAG2 WILD-TYPE	217	235	191

Figure S119. Get High-res Image Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'STAG2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00124 (Fisher's exact test), Q value = 0.027

Table S218. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
STAG2 MUTATED	9	1	1
STAG2 WILD-TYPE	187	189	267

Figure S120. Get High-res Image Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'STAG2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.594 (Fisher's exact test), Q value = 1

Table S219. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
STAG2 MUTATED	1	2	1	0
STAG2 WILD-TYPE	135	105	182	83

'STAG2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0137 (Fisher's exact test), Q value = 0.18

Table S220. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
STAG2 MUTATED	0	1	3
STAG2 WILD-TYPE	222	183	100

Figure S121. Get High-res Image Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'STAG2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.473 (Fisher's exact test), Q value = 1

Table S221. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
STAG2 MUTATED	2	0	2
STAG2 WILD-TYPE	182	162	157

'STAG2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.235 (Fisher's exact test), Q value = 0.95

Table S222. Gene #22: 'STAG2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
STAG2 MUTATED	0	0	2	2
STAG2 WILD-TYPE	90	138	186	87

'IRS4 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.114 (Fisher's exact test), Q value = 0.69

Table S223. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
IRS4 MUTATED	1	2	0	0
IRS4 WILD-TYPE	68	41	74	54

'IRS4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S224. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
IRS4 MUTATED	1	1	0	1
IRS4 WILD-TYPE	62	49	48	78

'IRS4 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.0528 (Fisher's exact test), Q value = 0.43

Table S225. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
IRS4 MUTATED	3	0	0	0
IRS4 WILD-TYPE	74	93	45	60

'IRS4 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.122 (Fisher's exact test), Q value = 0.71

Table S226. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
IRS4 MUTATED	0	1	2
IRS4 WILD-TYPE	138	60	74

'IRS4 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.773 (Fisher's exact test), Q value = 1

Table S227. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
IRS4 MUTATED	3	7	0
IRS4 WILD-TYPE	292	474	7

'IRS4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.696 (Fisher's exact test), Q value = 1

Table S228. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
IRS4 MUTATED	3	3	1	1
IRS4 WILD-TYPE	157	229	63	165

'IRS4 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.671 (Fisher's exact test), Q value = 1

Table S229. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
IRS4 MUTATED	5	3	2
IRS4 WILD-TYPE	222	232	190

'IRS4 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.237 (Fisher's exact test), Q value = 0.95

Table S230. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
IRS4 MUTATED	3	5	2
IRS4 WILD-TYPE	193	185	266

'IRS4 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.415 (Fisher's exact test), Q value = 1

Table S231. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
IRS4 MUTATED	1	3	3	0
IRS4 WILD-TYPE	135	104	180	83

'IRS4 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.691 (Fisher's exact test), Q value = 1

Table S232. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
IRS4 MUTATED	2	3	2
IRS4 WILD-TYPE	220	181	101

'IRS4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.271 (Fisher's exact test), Q value = 1

Table S233. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
IRS4 MUTATED	1	2	4
IRS4 WILD-TYPE	183	160	155

'IRS4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S234. Gene #23: 'IRS4 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
IRS4 MUTATED	1	2	3	1
IRS4 WILD-TYPE	89	136	185	88

'REN MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.477 (Fisher's exact test), Q value = 1

Table S235. Gene #24: 'REN MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
REN MUTATED	0	0	2	1
REN WILD-TYPE	69	43	72	53

'REN MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.416 (Fisher's exact test), Q value = 1

Table S236. Gene #24: 'REN MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
REN MUTATED	0	0	1	2
REN WILD-TYPE	63	50	47	77

'REN MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.0738 (Fisher's exact test), Q value = 0.52

Table S237. Gene #24: 'REN MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
REN MUTATED	1	1	3	0
REN WILD-TYPE	76	92	42	60

'REN MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.513 (Fisher's exact test), Q value = 1

Table S238. Gene #24: 'REN MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
REN MUTATED	4	0	1
REN WILD-TYPE	134	61	75

'REN MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00277 (Fisher's exact test), Q value = 0.053

Table S239. Gene #24: 'REN MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
REN MUTATED	7	0	0
REN WILD-TYPE	288	481	7

Figure S122. Get High-res Image Gene #24: 'REN MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'REN MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.00315 (Fisher's exact test), Q value = 0.058

Table S240. Gene #24: 'REN MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
REN MUTATED	5	0	0	0
REN WILD-TYPE	155	232	64	166

Figure S123. Get High-res Image Gene #24: 'REN MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'REN MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.203 (Fisher's exact test), Q value = 0.9

Table S241. Gene #24: 'REN MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
REN MUTATED	1	0	2
REN WILD-TYPE	226	235	190

'REN MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.785 (Fisher's exact test), Q value = 1

Table S242. Gene #24: 'REN MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
REN MUTATED	1	0	2
REN WILD-TYPE	195	190	266

'TNRC18 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.598 (Fisher's exact test), Q value = 1

Table S243. Gene #25: 'TNRC18 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TNRC18 MUTATED	3	9	0
TNRC18 WILD-TYPE	292	472	7

'TNRC18 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.18 (Fisher's exact test), Q value = 0.89

Table S244. Gene #25: 'TNRC18 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TNRC18 MUTATED	2	5	3	1
TNRC18 WILD-TYPE	158	227	61	165

'TNRC18 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.197 (Fisher's exact test), Q value = 0.9

Table S245. Gene #25: 'TNRC18 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TNRC18 MUTATED	4	2	6
TNRC18 WILD-TYPE	223	233	186

'TNRC18 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.874 (Fisher's exact test), Q value = 1

Table S246. Gene #25: 'TNRC18 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TNRC18 MUTATED	3	3	6
TNRC18 WILD-TYPE	193	187	262

'TNRC18 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.512 (Fisher's exact test), Q value = 1

Table S247. Gene #25: 'TNRC18 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TNRC18 MUTATED	4	2	4	0
TNRC18 WILD-TYPE	132	105	179	83

'TNRC18 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.18 (Fisher's exact test), Q value = 0.89

Table S248. Gene #25: 'TNRC18 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TNRC18 MUTATED	2	4	4
TNRC18 WILD-TYPE	220	180	99

'TNRC18 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S249. Gene #25: 'TNRC18 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TNRC18 MUTATED	3	3	3
TNRC18 WILD-TYPE	181	159	156

'TNRC18 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.345 (Fisher's exact test), Q value = 1

Table S250. Gene #25: 'TNRC18 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TNRC18 MUTATED	0	2	4	3
TNRC18 WILD-TYPE	90	136	184	86

'NRAS MUTATION STATUS' versus 'CN_CNMF'

P value = 0.669 (Fisher's exact test), Q value = 1

Table S251. Gene #26: 'NRAS MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
NRAS MUTATED	1	4	0
NRAS WILD-TYPE	294	477	7

'NRAS MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.254 (Fisher's exact test), Q value = 0.99

Table S252. Gene #26: 'NRAS MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
NRAS MUTATED	0	1	0	3
NRAS WILD-TYPE	160	231	64	163

'NRAS MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.107 (Fisher's exact test), Q value = 0.67

Table S253. Gene #26: 'NRAS MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
NRAS MUTATED	0	1	3
NRAS WILD-TYPE	227	234	189

'NRAS MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.311 (Fisher's exact test), Q value = 1

Table S254. Gene #26: 'NRAS MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
NRAS MUTATED	0	1	3
NRAS WILD-TYPE	196	189	265

'NRAS MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.303 (Fisher's exact test), Q value = 1

Table S255. Gene #26: 'NRAS MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
NRAS MUTATED	0	0	3	1
NRAS WILD-TYPE	136	107	180	82

'NRAS MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.682 (Fisher's exact test), Q value = 1

Table S256. Gene #26: 'NRAS MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
NRAS MUTATED	1	2	1
NRAS WILD-TYPE	221	182	102

'NRAS MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.331 (Fisher's exact test), Q value = 1

Table S257. Gene #26: 'NRAS MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
NRAS MUTATED	0	2	2
NRAS WILD-TYPE	184	160	157

'NRAS MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.76 (Fisher's exact test), Q value = 1

Table S258. Gene #26: 'NRAS MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
NRAS MUTATED	0	2	2	0
NRAS WILD-TYPE	90	136	186	89

'PLCG1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.642 (Fisher's exact test), Q value = 1

Table S259. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
PLCG1 MUTATED	2	0	1	2
PLCG1 WILD-TYPE	67	43	73	52

'PLCG1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.927 (Fisher's exact test), Q value = 1

Table S260. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
PLCG1 MUTATED	2	1	1	1
PLCG1 WILD-TYPE	61	49	47	78

'PLCG1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.868 (Fisher's exact test), Q value = 1

Table S261. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PLCG1 MUTATED	2	1	1	1
PLCG1 WILD-TYPE	75	92	44	59

'PLCG1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.841 (Fisher's exact test), Q value = 1

Table S262. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PLCG1 MUTATED	2	1	2
PLCG1 WILD-TYPE	136	60	74

'PLCG1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0111 (Fisher's exact test), Q value = 0.16

Table S263. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PLCG1 MUTATED	9	2	0
PLCG1 WILD-TYPE	286	479	7

Figure S124. Get High-res Image Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'PLCG1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.212 (Fisher's exact test), Q value = 0.91

Table S264. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PLCG1 MUTATED	4	1	1	1
PLCG1 WILD-TYPE	156	231	63	165

'PLCG1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.574 (Fisher's exact test), Q value = 1

Table S265. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PLCG1 MUTATED	4	2	1
PLCG1 WILD-TYPE	223	233	191

'PLCG1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.272 (Fisher's exact test), Q value = 1

Table S266. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PLCG1 MUTATED	4	2	1
PLCG1 WILD-TYPE	192	188	267

'PLCG1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.027 (Fisher's exact test), Q value = 0.29

Table S267. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PLCG1 MUTATED	5	0	1	0
PLCG1 WILD-TYPE	131	107	182	83

Figure S125. Get High-res Image Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'PLCG1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0651 (Fisher's exact test), Q value = 0.48

Table S268. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PLCG1 MUTATED	3	0	3
PLCG1 WILD-TYPE	219	184	100

'PLCG1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0538 (Fisher's exact test), Q value = 0.43

Table S269. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PLCG1 MUTATED	5	1	0
PLCG1 WILD-TYPE	179	161	159

'PLCG1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.15 (Fisher's exact test), Q value = 0.82

Table S270. Gene #27: 'PLCG1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PLCG1 MUTATED	0	2	1	3
PLCG1 WILD-TYPE	90	136	187	86

'SLC26A3 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.941 (Fisher's exact test), Q value = 1

Table S271. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
SLC26A3 MUTATED	1	1	2	2
SLC26A3 WILD-TYPE	68	42	72	52

'SLC26A3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.769 (Fisher's exact test), Q value = 1

Table S272. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
SLC26A3 MUTATED	2	1	2	1
SLC26A3 WILD-TYPE	61	49	46	78

'SLC26A3 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.466 (Fisher's exact test), Q value = 1

Table S273. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
SLC26A3 MUTATED	1	4	0	2
SLC26A3 WILD-TYPE	76	89	45	58

'SLC26A3 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.362 (Fisher's exact test), Q value = 1

Table S274. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
SLC26A3 MUTATED	4	0	3
SLC26A3 WILD-TYPE	134	61	73

'SLC26A3 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0112 (Fisher's exact test), Q value = 0.16

Table S275. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SLC26A3 MUTATED	9	2	0
SLC26A3 WILD-TYPE	286	479	7

Figure S126. Get High-res Image Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'SLC26A3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0231 (Fisher's exact test), Q value = 0.26

Table S276. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SLC26A3 MUTATED	5	1	0	0
SLC26A3 WILD-TYPE	155	231	64	166

Figure S127. Get High-res Image Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'SLC26A3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.00444 (Fisher's exact test), Q value = 0.079

Table S277. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SLC26A3 MUTATED	7	1	0
SLC26A3 WILD-TYPE	220	234	192

Figure S128. Get High-res Image Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'SLC26A3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00611 (Fisher's exact test), Q value = 0.1

Table S278. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SLC26A3 MUTATED	6	2	0
SLC26A3 WILD-TYPE	190	188	268

Figure S129. Get High-res Image Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'SLC26A3 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0451 (Fisher's exact test), Q value = 0.4

Table S279. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SLC26A3 MUTATED	1	3	0	0
SLC26A3 WILD-TYPE	135	104	183	83

Figure S130. Get High-res Image Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'SLC26A3 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0268 (Fisher's exact test), Q value = 0.29

Table S280. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SLC26A3 MUTATED	1	0	3
SLC26A3 WILD-TYPE	221	184	100

Figure S131. Get High-res Image Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'SLC26A3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S281. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SLC26A3 MUTATED	2	1	1
SLC26A3 WILD-TYPE	182	161	158

'SLC26A3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.185 (Fisher's exact test), Q value = 0.9

Table S282. Gene #28: 'SLC26A3 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SLC26A3 MUTATED	1	0	1	2
SLC26A3 WILD-TYPE	89	138	187	87

'ZBTB20 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00013 (Fisher's exact test), Q value = 0.0037

Table S283. Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ZBTB20 MUTATED	0	22	0
ZBTB20 WILD-TYPE	295	459	7

Figure S132. Get High-res Image Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'ZBTB20 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 4e-05 (Fisher's exact test), Q value = 0.0014

Table S284. Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ZBTB20 MUTATED	2	3	0	16
ZBTB20 WILD-TYPE	158	229	64	150

Figure S133. Get High-res Image Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'ZBTB20 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 9e-05 (Fisher's exact test), Q value = 0.0028

Table S285. Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ZBTB20 MUTATED	3	3	16
ZBTB20 WILD-TYPE	224	232	176

Figure S134. Get High-res Image Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'ZBTB20 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 5e-05 (Fisher's exact test), Q value = 0.0016

Table S286. Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ZBTB20 MUTATED	0	3	19
ZBTB20 WILD-TYPE	196	187	249

Figure S135. Get High-res Image Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'ZBTB20 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.158 (Fisher's exact test), Q value = 0.84

Table S287. Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ZBTB20 MUTATED	3	2	12	4
ZBTB20 WILD-TYPE	133	105	171	79

'ZBTB20 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0205 (Fisher's exact test), Q value = 0.24

Table S288. Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ZBTB20 MUTATED	5	14	2
ZBTB20 WILD-TYPE	217	170	101

Figure S136. Get High-res Image Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'ZBTB20 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0404 (Fisher's exact test), Q value = 0.38

Table S289. Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ZBTB20 MUTATED	3	7	11
ZBTB20 WILD-TYPE	181	155	148

Figure S137. Get High-res Image Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'ZBTB20 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0317 (Fisher's exact test), Q value = 0.32

Table S290. Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ZBTB20 MUTATED	1	5	14	1
ZBTB20 WILD-TYPE	89	133	174	88

Figure S138. Get High-res Image Gene #29: 'ZBTB20 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'TRERF1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.309 (Fisher's exact test), Q value = 1

Table S291. Gene #30: 'TRERF1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TRERF1 MUTATED	1	6	0
TRERF1 WILD-TYPE	294	475	7

'TRERF1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.864 (Fisher's exact test), Q value = 1

Table S292. Gene #30: 'TRERF1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TRERF1 MUTATED	2	3	1	1
TRERF1 WILD-TYPE	158	229	63	165

'TRERF1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S293. Gene #30: 'TRERF1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TRERF1 MUTATED	2	2	2
TRERF1 WILD-TYPE	225	233	190

'TRERF1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0187 (Fisher's exact test), Q value = 0.23

Table S294. Gene #30: 'TRERF1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TRERF1 MUTATED	0	5	1
TRERF1 WILD-TYPE	196	185	267

Figure S139. Get High-res Image Gene #30: 'TRERF1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'TRERF1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.389 (Fisher's exact test), Q value = 1

Table S295. Gene #30: 'TRERF1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TRERF1 MUTATED	1	3	2	0
TRERF1 WILD-TYPE	135	104	181	83

'TRERF1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.757 (Fisher's exact test), Q value = 1

Table S296. Gene #30: 'TRERF1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TRERF1 MUTATED	2	2	2
TRERF1 WILD-TYPE	220	182	101

'TRERF1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.104 (Fisher's exact test), Q value = 0.66

Table S297. Gene #30: 'TRERF1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TRERF1 MUTATED	2	0	4
TRERF1 WILD-TYPE	182	162	155

'TRERF1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.353 (Fisher's exact test), Q value = 1

Table S298. Gene #30: 'TRERF1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TRERF1 MUTATED	1	0	4	1
TRERF1 WILD-TYPE	89	138	184	88

'MX2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.598 (Fisher's exact test), Q value = 1

Table S299. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
MX2 MUTATED	2	0	2	0
MX2 WILD-TYPE	67	43	72	54

'MX2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.841 (Fisher's exact test), Q value = 1

Table S300. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
MX2 MUTATED	1	0	1	2
MX2 WILD-TYPE	62	50	47	77

'MX2 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.443 (Fisher's exact test), Q value = 1

Table S301. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
MX2 MUTATED	2	0	1	1
MX2 WILD-TYPE	75	93	44	59

'MX2 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.442 (Fisher's exact test), Q value = 1

Table S302. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
MX2 MUTATED	1	1	2
MX2 WILD-TYPE	137	60	74

'MX2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.365 (Fisher's exact test), Q value = 1

Table S303. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
MX2 MUTATED	5	4	0
MX2 WILD-TYPE	290	477	7

'MX2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.717 (Fisher's exact test), Q value = 1

Table S304. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
MX2 MUTATED	2	1	0	2
MX2 WILD-TYPE	158	231	64	164

'MX2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S305. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
MX2 MUTATED	1	2	1
MX2 WILD-TYPE	226	233	191

'MX2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S306. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
MX2 MUTATED	1	1	2
MX2 WILD-TYPE	195	189	266

'MX2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.367 (Fisher's exact test), Q value = 1

Table S307. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
MX2 MUTATED	0	2	1	1
MX2 WILD-TYPE	136	105	182	82

'MX2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S308. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
MX2 MUTATED	2	1	1
MX2 WILD-TYPE	220	183	102

'MX2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S309. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
MX2 MUTATED	2	1	1
MX2 WILD-TYPE	182	161	158

'MX2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.639 (Fisher's exact test), Q value = 1

Table S310. Gene #31: 'MX2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
MX2 MUTATED	0	2	1	1
MX2 WILD-TYPE	90	136	187	88

'ZMIZ1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.505 (Fisher's exact test), Q value = 1

Table S311. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
ZMIZ1 MUTATED	2	1	0	1
ZMIZ1 WILD-TYPE	67	42	74	53

'ZMIZ1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.912 (Fisher's exact test), Q value = 1

Table S312. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
ZMIZ1 MUTATED	1	1	0	2
ZMIZ1 WILD-TYPE	62	49	48	77

'ZMIZ1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.645 (Fisher's exact test), Q value = 1

Table S313. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
ZMIZ1 MUTATED	2	2	0	0
ZMIZ1 WILD-TYPE	75	91	45	60

'ZMIZ1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.446 (Fisher's exact test), Q value = 1

Table S314. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
ZMIZ1 MUTATED	1	1	2
ZMIZ1 WILD-TYPE	137	60	74

'ZMIZ1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.233 (Fisher's exact test), Q value = 0.95

Table S315. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ZMIZ1 MUTATED	2	10	0
ZMIZ1 WILD-TYPE	293	471	7

'ZMIZ1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.328 (Fisher's exact test), Q value = 1

Table S316. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ZMIZ1 MUTATED	2	2	0	5
ZMIZ1 WILD-TYPE	158	230	64	161

'ZMIZ1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.868 (Fisher's exact test), Q value = 1

Table S317. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ZMIZ1 MUTATED	3	5	3
ZMIZ1 WILD-TYPE	224	230	189

'ZMIZ1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.344 (Fisher's exact test), Q value = 1

Table S318. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ZMIZ1 MUTATED	1	4	6
ZMIZ1 WILD-TYPE	195	186	262

'ZMIZ1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.481 (Fisher's exact test), Q value = 1

Table S319. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ZMIZ1 MUTATED	1	2	3	3
ZMIZ1 WILD-TYPE	135	105	180	80

'ZMIZ1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.676 (Fisher's exact test), Q value = 1

Table S320. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ZMIZ1 MUTATED	5	2	2
ZMIZ1 WILD-TYPE	217	182	101

'ZMIZ1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0183 (Fisher's exact test), Q value = 0.22

Table S321. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ZMIZ1 MUTATED	0	6	3
ZMIZ1 WILD-TYPE	184	156	156

Figure S140. Get High-res Image Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'ZMIZ1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.418 (Fisher's exact test), Q value = 1

Table S322. Gene #32: 'ZMIZ1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ZMIZ1 MUTATED	0	4	4	1
ZMIZ1 WILD-TYPE	90	134	184	88

'DDX5 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.217 (Fisher's exact test), Q value = 0.92

Table S323. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
DDX5 MUTATED	1	0	0	2
DDX5 WILD-TYPE	68	43	74	52

'DDX5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S324. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
DDX5 MUTATED	1	1	0	1
DDX5 WILD-TYPE	62	49	48	78

'DDX5 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.537 (Fisher's exact test), Q value = 1

Table S325. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
DDX5 MUTATED	0	2	1	1
DDX5 WILD-TYPE	77	91	44	59

'DDX5 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.445 (Fisher's exact test), Q value = 1

Table S326. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
DDX5 MUTATED	1	1	2
DDX5 WILD-TYPE	137	60	74

'DDX5 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S327. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
DDX5 MUTATED	3	6	0
DDX5 WILD-TYPE	292	475	7

'DDX5 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.675 (Fisher's exact test), Q value = 1

Table S328. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
DDX5 MUTATED	3	2	0	2
DDX5 WILD-TYPE	157	230	64	164

'DDX5 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.878 (Fisher's exact test), Q value = 1

Table S329. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
DDX5 MUTATED	2	3	1
DDX5 WILD-TYPE	225	232	191

'DDX5 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.592 (Fisher's exact test), Q value = 1

Table S330. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
DDX5 MUTATED	1	3	2
DDX5 WILD-TYPE	195	187	266

'DDX5 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.264 (Fisher's exact test), Q value = 1

Table S331. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
DDX5 MUTATED	0	2	3	0
DDX5 WILD-TYPE	136	105	180	83

'DDX5 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.443 (Fisher's exact test), Q value = 1

Table S332. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
DDX5 MUTATED	1	3	1
DDX5 WILD-TYPE	221	181	102

'DDX5 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0274 (Fisher's exact test), Q value = 0.29

Table S333. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
DDX5 MUTATED	0	1	4
DDX5 WILD-TYPE	184	161	155

Figure S141. Get High-res Image Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'DDX5 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.317 (Fisher's exact test), Q value = 1

Table S334. Gene #33: 'DDX5 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
DDX5 MUTATED	0	1	4	0
DDX5 WILD-TYPE	90	137	184	89

'DNMT3A MUTATION STATUS' versus 'CN_CNMF'

P value = 0.032 (Fisher's exact test), Q value = 0.32

Table S335. Gene #34: 'DNMT3A MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
DNMT3A MUTATED	0	10	0
DNMT3A WILD-TYPE	295	471	7

Figure S142. Get High-res Image Gene #34: 'DNMT3A MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'DNMT3A MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S336. Gene #34: 'DNMT3A MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
DNMT3A MUTATED	2	4	1	3
DNMT3A WILD-TYPE	158	228	63	163

'DNMT3A MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.222 (Fisher's exact test), Q value = 0.92

Table S337. Gene #34: 'DNMT3A MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
DNMT3A MUTATED	1	5	4
DNMT3A WILD-TYPE	226	230	188

'DNMT3A MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0859 (Fisher's exact test), Q value = 0.58

Table S338. Gene #34: 'DNMT3A MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
DNMT3A MUTATED	0	4	6
DNMT3A WILD-TYPE	196	186	262

'DNMT3A MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.48 (Fisher's exact test), Q value = 1

Table S339. Gene #34: 'DNMT3A MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
DNMT3A MUTATED	1	2	6	1
DNMT3A WILD-TYPE	135	105	177	82

'DNMT3A MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0439 (Fisher's exact test), Q value = 0.4

Table S340. Gene #34: 'DNMT3A MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
DNMT3A MUTATED	1	5	4
DNMT3A WILD-TYPE	221	179	99

Figure S143. Get High-res Image Gene #34: 'DNMT3A MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'DNMT3A MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.923 (Fisher's exact test), Q value = 1

Table S341. Gene #34: 'DNMT3A MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
DNMT3A MUTATED	3	4	3
DNMT3A WILD-TYPE	181	158	156

'DNMT3A MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.971 (Fisher's exact test), Q value = 1

Table S342. Gene #34: 'DNMT3A MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
DNMT3A MUTATED	1	3	4	2
DNMT3A WILD-TYPE	89	135	184	87

'PTPN11 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S343. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
PTPN11 MUTATED	1	0	1	1
PTPN11 WILD-TYPE	68	43	73	53

'PTPN11 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.787 (Fisher's exact test), Q value = 1

Table S344. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
PTPN11 MUTATED	1	0	0	2
PTPN11 WILD-TYPE	62	50	48	77

'PTPN11 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.00686 (Fisher's exact test), Q value = 0.11

Table S345. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PTPN11 MUTATED	0	0	3	1
PTPN11 WILD-TYPE	77	93	42	59

Figure S144. Get High-res Image Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

'PTPN11 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S346. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PTPN11 MUTATED	2	1	1
PTPN11 WILD-TYPE	136	60	75

'PTPN11 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.56 (Fisher's exact test), Q value = 1

Table S347. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PTPN11 MUTATED	5	5	0
PTPN11 WILD-TYPE	290	476	7

'PTPN11 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0314 (Fisher's exact test), Q value = 0.32

Table S348. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PTPN11 MUTATED	4	1	3	1
PTPN11 WILD-TYPE	156	231	61	165

Figure S145. Get High-res Image Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'PTPN11 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.228 (Fisher's exact test), Q value = 0.94

Table S349. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PTPN11 MUTATED	5	1	3
PTPN11 WILD-TYPE	222	234	189

'PTPN11 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.267 (Fisher's exact test), Q value = 1

Table S350. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PTPN11 MUTATED	5	2	2
PTPN11 WILD-TYPE	191	188	266

'PTPN11 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.22 (Fisher's exact test), Q value = 0.92

Table S351. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PTPN11 MUTATED	3	3	1	0
PTPN11 WILD-TYPE	133	104	182	83

'PTPN11 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.00559 (Fisher's exact test), Q value = 0.094

Table S352. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PTPN11 MUTATED	1	1	5
PTPN11 WILD-TYPE	221	183	98

Figure S146. Get High-res Image Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'PTPN11 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0156 (Fisher's exact test), Q value = 0.2

Table S353. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PTPN11 MUTATED	6	0	1
PTPN11 WILD-TYPE	178	162	158

Figure S147. Get High-res Image Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'PTPN11 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.00245 (Fisher's exact test), Q value = 0.048

Table S354. Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PTPN11 MUTATED	1	0	1	5
PTPN11 WILD-TYPE	89	138	187	84

Figure S148. Get High-res Image Gene #35: 'PTPN11 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'ZNF292 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.476 (Fisher's exact test), Q value = 1

Table S355. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
ZNF292 MUTATED	0	0	2	1
ZNF292 WILD-TYPE	69	43	72	53

'ZNF292 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.224 (Fisher's exact test), Q value = 0.92

Table S356. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
ZNF292 MUTATED	0	0	2	1
ZNF292 WILD-TYPE	63	50	46	78

'ZNF292 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.397 (Fisher's exact test), Q value = 1

Table S357. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
ZNF292 MUTATED	0	2	1	0
ZNF292 WILD-TYPE	77	91	44	60

'ZNF292 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.31 (Fisher's exact test), Q value = 1

Table S358. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
ZNF292 MUTATED	1	0	2
ZNF292 WILD-TYPE	137	61	74

'ZNF292 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.252 (Fisher's exact test), Q value = 0.99

Table S359. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ZNF292 MUTATED	3	14	0
ZNF292 WILD-TYPE	292	467	7

'ZNF292 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.168 (Fisher's exact test), Q value = 0.86

Table S360. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ZNF292 MUTATED	2	4	1	8
ZNF292 WILD-TYPE	158	228	63	158

'ZNF292 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.155 (Fisher's exact test), Q value = 0.83

Table S361. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ZNF292 MUTATED	3	4	8
ZNF292 WILD-TYPE	224	231	184

'ZNF292 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0853 (Fisher's exact test), Q value = 0.58

Table S362. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ZNF292 MUTATED	1	5	9
ZNF292 WILD-TYPE	195	185	259

'ZNF292 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.426 (Fisher's exact test), Q value = 1

Table S363. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ZNF292 MUTATED	2	3	8	1
ZNF292 WILD-TYPE	134	104	175	82

'ZNF292 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.29 (Fisher's exact test), Q value = 1

Table S364. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ZNF292 MUTATED	4	8	2
ZNF292 WILD-TYPE	218	176	101

'ZNF292 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.083 (Fisher's exact test), Q value = 0.57

Table S365. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ZNF292 MUTATED	2	4	8
ZNF292 WILD-TYPE	182	158	151

'ZNF292 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0544 (Fisher's exact test), Q value = 0.43

Table S366. Gene #36: 'ZNF292 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ZNF292 MUTATED	0	3	10	1
ZNF292 WILD-TYPE	90	135	178	88

'DSP MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.489 (Fisher's exact test), Q value = 1

Table S367. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
DSP MUTATED	3	0	2	3
DSP WILD-TYPE	66	43	72	51

'DSP MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.962 (Fisher's exact test), Q value = 1

Table S368. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
DSP MUTATED	2	1	2	3
DSP WILD-TYPE	61	49	46	76

'DSP MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.57 (Fisher's exact test), Q value = 1

Table S369. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
DSP MUTATED	3	5	3	1
DSP WILD-TYPE	74	88	42	59

'DSP MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.0747 (Fisher's exact test), Q value = 0.52

Table S370. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
DSP MUTATED	6	0	6
DSP WILD-TYPE	132	61	70

'DSP MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0704 (Fisher's exact test), Q value = 0.51

Table S371. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
DSP MUTATED	13	8	0
DSP WILD-TYPE	282	473	7

'DSP MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0446 (Fisher's exact test), Q value = 0.4

Table S372. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
DSP MUTATED	9	3	1	2
DSP WILD-TYPE	151	229	63	164

Figure S149. Get High-res Image Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'DSP MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.669 (Fisher's exact test), Q value = 1

Table S373. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
DSP MUTATED	5	3	2
DSP WILD-TYPE	222	232	190

'DSP MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.727 (Fisher's exact test), Q value = 1

Table S374. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
DSP MUTATED	4	3	3
DSP WILD-TYPE	192	187	265

'DSP MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.71 (Fisher's exact test), Q value = 1

Table S375. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
DSP MUTATED	3	3	2	1
DSP WILD-TYPE	133	104	181	82

'DSP MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0163 (Fisher's exact test), Q value = 0.21

Table S376. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
DSP MUTATED	5	0	4
DSP WILD-TYPE	217	184	99

Figure S150. Get High-res Image Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'DSP MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.914 (Fisher's exact test), Q value = 1

Table S377. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
DSP MUTATED	4	3	2
DSP WILD-TYPE	180	159	157

'DSP MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.548 (Fisher's exact test), Q value = 1

Table S378. Gene #37: 'DSP MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
DSP MUTATED	2	2	2	3
DSP WILD-TYPE	88	136	186	86

'BRAF MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.766 (Fisher's exact test), Q value = 1

Table S379. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
BRAF MUTATED	1	1	2	0
BRAF WILD-TYPE	68	42	72	54

'BRAF MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.711 (Fisher's exact test), Q value = 1

Table S380. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
BRAF MUTATED	2	0	1	1
BRAF WILD-TYPE	61	50	47	78

'BRAF MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.321 (Fisher's exact test), Q value = 1

Table S381. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
BRAF MUTATED	2	1	0	3
BRAF WILD-TYPE	75	92	45	57

'BRAF MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.0294 (Fisher's exact test), Q value = 0.3

Table S382. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
BRAF MUTATED	2	4	0
BRAF WILD-TYPE	136	57	76

Figure S151. Get High-res Image Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

'BRAF MUTATION STATUS' versus 'CN_CNMF'

P value = 0.409 (Fisher's exact test), Q value = 1

Table S383. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
BRAF MUTATED	6	5	0
BRAF WILD-TYPE	289	476	7

'BRAF MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.00022 (Fisher's exact test), Q value = 0.0059

Table S384. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
BRAF MUTATED	3	0	4	0
BRAF WILD-TYPE	157	232	60	166

Figure S152. Get High-res Image Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'BRAF MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0496 (Fisher's exact test), Q value = 0.42

Table S385. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
BRAF MUTATED	5	0	3
BRAF WILD-TYPE	222	235	189

Figure S153. Get High-res Image Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'BRAF MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.359 (Fisher's exact test), Q value = 1

Table S386. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
BRAF MUTATED	4	1	3
BRAF WILD-TYPE	192	189	265

'BRAF MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.263 (Fisher's exact test), Q value = 1

Table S387. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
BRAF MUTATED	0	2	3	0
BRAF WILD-TYPE	136	105	180	83

'BRAF MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0903 (Fisher's exact test), Q value = 0.6

Table S388. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
BRAF MUTATED	0	3	2
BRAF WILD-TYPE	222	181	101

'BRAF MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0614 (Fisher's exact test), Q value = 0.46

Table S389. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
BRAF MUTATED	1	0	4
BRAF WILD-TYPE	183	162	155

'BRAF MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.196 (Fisher's exact test), Q value = 0.9

Table S390. Gene #38: 'BRAF MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
BRAF MUTATED	0	0	3	2
BRAF WILD-TYPE	90	138	185	87

'EGFR MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.00651 (Fisher's exact test), Q value = 0.11

Table S391. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
EGFR MUTATED	20	7	31	10
EGFR WILD-TYPE	49	36	43	44

Figure S154. Get High-res Image Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

'EGFR MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.056 (Fisher's exact test), Q value = 0.44

Table S392. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
EGFR MUTATED	18	7	17	26
EGFR WILD-TYPE	45	43	31	53

'EGFR MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.51 (Fisher's exact test), Q value = 1

Table S393. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
EGFR MUTATED	22	27	8	17
EGFR WILD-TYPE	55	66	37	43

'EGFR MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.14 (Fisher's exact test), Q value = 0.79

Table S394. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
EGFR MUTATED	30	19	25
EGFR WILD-TYPE	108	42	51

'EGFR MUTATION STATUS' versus 'CN_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S395. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
EGFR MUTATED	95	11	1
EGFR WILD-TYPE	200	470	6

Figure S155. Get High-res Image Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'EGFR MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S396. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
EGFR MUTATED	47	0	6	3
EGFR WILD-TYPE	113	232	58	163

Figure S156. Get High-res Image Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'EGFR MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S397. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
EGFR MUTATED	71	0	9
EGFR WILD-TYPE	156	235	183

Figure S157. Get High-res Image Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'EGFR MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S398. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
EGFR MUTATED	69	2	9
EGFR WILD-TYPE	127	188	259

Figure S158. Get High-res Image Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'EGFR MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0106 (Fisher's exact test), Q value = 0.15

Table S399. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
EGFR MUTATED	11	11	13	0
EGFR WILD-TYPE	125	96	170	83

Figure S159. Get High-res Image Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'EGFR MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S400. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
EGFR MUTATED	1	9	25
EGFR WILD-TYPE	221	175	78

Figure S160. Get High-res Image Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'EGFR MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S401. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
EGFR MUTATED	23	0	12
EGFR WILD-TYPE	161	162	147

Figure S161. Get High-res Image Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'EGFR MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1e-05 (Fisher's exact test), Q value = 0.00037

Table S402. Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
EGFR MUTATED	0	0	8	27
EGFR WILD-TYPE	90	138	180	62

Figure S162. Get High-res Image Gene #39: 'EGFR MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'RBPJ MUTATION STATUS' versus 'CN_CNMF'

P value = 0.107 (Fisher's exact test), Q value = 0.67

Table S403. Gene #40: 'RBPJ MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
RBPJ MUTATED	0	7	0
RBPJ WILD-TYPE	295	474	7

'RBPJ MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0397 (Fisher's exact test), Q value = 0.37

Table S404. Gene #40: 'RBPJ MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
RBPJ MUTATED	0	1	1	5
RBPJ WILD-TYPE	160	231	63	161

Figure S163. Get High-res Image Gene #40: 'RBPJ MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'RBPJ MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0267 (Fisher's exact test), Q value = 0.29

Table S405. Gene #40: 'RBPJ MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
RBPJ MUTATED	2	0	5
RBPJ WILD-TYPE	225	235	187

Figure S164. Get High-res Image Gene #40: 'RBPJ MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'RBPJ MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.142 (Fisher's exact test), Q value = 0.79

Table S406. Gene #40: 'RBPJ MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
RBPJ MUTATED	0	2	5
RBPJ WILD-TYPE	196	188	263

'RBPJ MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.332 (Fisher's exact test), Q value = 1

Table S407. Gene #40: 'RBPJ MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
RBPJ MUTATED	0	2	4	1
RBPJ WILD-TYPE	136	105	179	82

'RBPJ MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0285 (Fisher's exact test), Q value = 0.29

Table S408. Gene #40: 'RBPJ MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
RBPJ MUTATED	0	5	2
RBPJ WILD-TYPE	222	179	101

Figure S165. Get High-res Image Gene #40: 'RBPJ MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'RBPJ MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.116 (Fisher's exact test), Q value = 0.69

Table S409. Gene #40: 'RBPJ MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
RBPJ MUTATED	1	1	5
RBPJ WILD-TYPE	183	161	154

'RBPJ MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.444 (Fisher's exact test), Q value = 1

Table S410. Gene #40: 'RBPJ MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
RBPJ MUTATED	0	1	4	2
RBPJ WILD-TYPE	90	137	184	87

'SEMG2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.501 (Fisher's exact test), Q value = 1

Table S411. Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
SEMG2 MUTATED	2	1	6	2
SEMG2 WILD-TYPE	67	42	68	52

'SEMG2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.423 (Fisher's exact test), Q value = 1

Table S412. Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
SEMG2 MUTATED	1	2	2	6
SEMG2 WILD-TYPE	62	48	46	73

'SEMG2 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.548 (Fisher's exact test), Q value = 1

Table S413. Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
SEMG2 MUTATED	3	6	1	1
SEMG2 WILD-TYPE	74	87	44	59

'SEMG2 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.921 (Fisher's exact test), Q value = 1

Table S414. Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
SEMG2 MUTATED	5	3	3
SEMG2 WILD-TYPE	133	58	73

'SEMG2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00024 (Fisher's exact test), Q value = 0.0064

Table S415. Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SEMG2 MUTATED	12	1	0
SEMG2 WILD-TYPE	283	480	7

Figure S166. Get High-res Image Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'SEMG2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0361 (Fisher's exact test), Q value = 0.35

Table S416. Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SEMG2 MUTATED	4	0	0	1
SEMG2 WILD-TYPE	156	232	64	165

Figure S167. Get High-res Image Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'SEMG2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0215 (Fisher's exact test), Q value = 0.25

Table S417. Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SEMG2 MUTATED	5	0	1
SEMG2 WILD-TYPE	222	235	191

Figure S168. Get High-res Image Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'SEMG2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0243 (Fisher's exact test), Q value = 0.27

Table S418. Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SEMG2 MUTATED	5	0	1
SEMG2 WILD-TYPE	191	190	267

Figure S169. Get High-res Image Gene #41: 'SEMG2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'ARID2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.457 (Fisher's exact test), Q value = 1

Table S419. Gene #42: 'ARID2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ARID2 MUTATED	3	10	0
ARID2 WILD-TYPE	292	471	7

'ARID2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.945 (Fisher's exact test), Q value = 1

Table S420. Gene #42: 'ARID2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ARID2 MUTATED	3	5	1	2
ARID2 WILD-TYPE	157	227	63	164

'ARID2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S421. Gene #42: 'ARID2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ARID2 MUTATED	4	4	4
ARID2 WILD-TYPE	223	231	188

'ARID2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.144 (Fisher's exact test), Q value = 0.8

Table S422. Gene #42: 'ARID2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ARID2 MUTATED	1	6	5
ARID2 WILD-TYPE	195	184	263

'ARID2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.601 (Fisher's exact test), Q value = 1

Table S423. Gene #42: 'ARID2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ARID2 MUTATED	2	4	3	1
ARID2 WILD-TYPE	134	103	180	82

'ARID2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.343 (Fisher's exact test), Q value = 1

Table S424. Gene #42: 'ARID2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ARID2 MUTATED	3	3	4
ARID2 WILD-TYPE	219	181	99

'ARID2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.479 (Fisher's exact test), Q value = 1

Table S425. Gene #42: 'ARID2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ARID2 MUTATED	3	2	5
ARID2 WILD-TYPE	181	160	154

'ARID2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.461 (Fisher's exact test), Q value = 1

Table S426. Gene #42: 'ARID2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ARID2 MUTATED	1	1	5	3
ARID2 WILD-TYPE	89	137	183	86

'ANKRD36 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.306 (Fisher's exact test), Q value = 1

Table S427. Gene #43: 'ANKRD36 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ANKRD36 MUTATED	1	6	0
ANKRD36 WILD-TYPE	294	475	7

'ANKRD36 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0921 (Fisher's exact test), Q value = 0.6

Table S428. Gene #43: 'ANKRD36 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ANKRD36 MUTATED	1	6	0	0
ANKRD36 WILD-TYPE	159	226	64	166

'ANKRD36 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.408 (Fisher's exact test), Q value = 1

Table S429. Gene #43: 'ANKRD36 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ANKRD36 MUTATED	1	4	2
ANKRD36 WILD-TYPE	226	231	190

'ANKRD36 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.31 (Fisher's exact test), Q value = 1

Table S430. Gene #43: 'ANKRD36 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ANKRD36 MUTATED	1	4	2
ANKRD36 WILD-TYPE	195	186	266

'ANKRD36 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.738 (Fisher's exact test), Q value = 1

Table S431. Gene #43: 'ANKRD36 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ANKRD36 MUTATED	1	1	3	2
ANKRD36 WILD-TYPE	135	106	180	81

'ANKRD36 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S432. Gene #43: 'ANKRD36 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ANKRD36 MUTATED	3	3	1
ANKRD36 WILD-TYPE	219	181	102

'ANKRD36 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.895 (Fisher's exact test), Q value = 1

Table S433. Gene #43: 'ANKRD36 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ANKRD36 MUTATED	2	3	2
ANKRD36 WILD-TYPE	182	159	157

'ANKRD36 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.948 (Fisher's exact test), Q value = 1

Table S434. Gene #43: 'ANKRD36 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ANKRD36 MUTATED	1	3	2	1
ANKRD36 WILD-TYPE	89	135	186	88

'SRPX MUTATION STATUS' versus 'CN_CNMF'

P value = 0.649 (Fisher's exact test), Q value = 1

Table S435. Gene #44: 'SRPX MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SRPX MUTATED	2	2	0
SRPX WILD-TYPE	293	479	7

'SRPX MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.281 (Fisher's exact test), Q value = 1

Table S436. Gene #44: 'SRPX MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SRPX MUTATED	2	0	0	2
SRPX WILD-TYPE	158	232	64	164

'SRPX MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.558 (Fisher's exact test), Q value = 1

Table S437. Gene #44: 'SRPX MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SRPX MUTATED	2	2	0
SRPX WILD-TYPE	225	233	192

'SRPX MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.57 (Fisher's exact test), Q value = 1

Table S438. Gene #44: 'SRPX MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SRPX MUTATED	2	0	2
SRPX WILD-TYPE	194	190	266

'SRPX MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.274 (Fisher's exact test), Q value = 1

Table S439. Gene #44: 'SRPX MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SRPX MUTATED	2	1	0	1
SRPX WILD-TYPE	134	106	183	82

'SRPX MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.197 (Fisher's exact test), Q value = 0.9

Table S440. Gene #44: 'SRPX MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SRPX MUTATED	2	0	2
SRPX WILD-TYPE	220	184	101

'SRPX MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.394 (Fisher's exact test), Q value = 1

Table S441. Gene #44: 'SRPX MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SRPX MUTATED	3	1	0
SRPX WILD-TYPE	181	161	159

'SRPX MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0622 (Fisher's exact test), Q value = 0.47

Table S442. Gene #44: 'SRPX MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SRPX MUTATED	0	2	0	2
SRPX WILD-TYPE	90	136	188	87

'FAM83D MUTATION STATUS' versus 'CN_CNMF'

P value = 0.402 (Fisher's exact test), Q value = 1

Table S443. Gene #45: 'FAM83D MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
FAM83D MUTATED	3	2	0
FAM83D WILD-TYPE	292	479	7

'FAM83D MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.474 (Fisher's exact test), Q value = 1

Table S444. Gene #45: 'FAM83D MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
FAM83D MUTATED	3	1	0	1
FAM83D WILD-TYPE	157	231	64	165

'FAM83D MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.841 (Fisher's exact test), Q value = 1

Table S445. Gene #45: 'FAM83D MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
FAM83D MUTATED	2	1	1
FAM83D WILD-TYPE	225	234	191

'FAM83D MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.824 (Fisher's exact test), Q value = 1

Table S446. Gene #45: 'FAM83D MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
FAM83D MUTATED	2	1	1
FAM83D WILD-TYPE	194	189	267

'FAM83D MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S447. Gene #45: 'FAM83D MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
FAM83D MUTATED	1	1	1	0
FAM83D WILD-TYPE	135	106	182	83

'FAM83D MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0524 (Fisher's exact test), Q value = 0.43

Table S448. Gene #45: 'FAM83D MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
FAM83D MUTATED	0	1	2
FAM83D WILD-TYPE	222	183	101

'FAM83D MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S449. Gene #45: 'FAM83D MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
FAM83D MUTATED	1	1	1
FAM83D WILD-TYPE	183	161	158

'FAM83D MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.776 (Fisher's exact test), Q value = 1

Table S450. Gene #45: 'FAM83D MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
FAM83D MUTATED	0	1	1	1
FAM83D WILD-TYPE	90	137	187	88

'AK7 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.137 (Fisher's exact test), Q value = 0.77

Table S451. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
AK7 MUTATED	0	0	2	3
AK7 WILD-TYPE	69	43	72	51

'AK7 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.125 (Fisher's exact test), Q value = 0.72

Table S452. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
AK7 MUTATED	0	0	1	4
AK7 WILD-TYPE	63	50	47	75

'AK7 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.587 (Fisher's exact test), Q value = 1

Table S453. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
AK7 MUTATED	1	3	1	0
AK7 WILD-TYPE	76	90	44	60

'AK7 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.236 (Fisher's exact test), Q value = 0.95

Table S454. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
AK7 MUTATED	2	0	3
AK7 WILD-TYPE	136	61	73

'AK7 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0515 (Fisher's exact test), Q value = 0.43

Table S455. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
AK7 MUTATED	7	2	0
AK7 WILD-TYPE	288	479	7

'AK7 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0711 (Fisher's exact test), Q value = 0.51

Table S456. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
AK7 MUTATED	4	1	0	0
AK7 WILD-TYPE	156	231	64	166

'AK7 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.165 (Fisher's exact test), Q value = 0.85

Table S457. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
AK7 MUTATED	5	1	1
AK7 WILD-TYPE	222	234	191

'AK7 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0875 (Fisher's exact test), Q value = 0.58

Table S458. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
AK7 MUTATED	5	1	1
AK7 WILD-TYPE	191	189	267

'AK7 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0826 (Fisher's exact test), Q value = 0.56

Table S459. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
AK7 MUTATED	0	3	1	0
AK7 WILD-TYPE	136	104	182	83

'AK7 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0017 (Fisher's exact test), Q value = 0.036

Table S460. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
AK7 MUTATED	0	0	4
AK7 WILD-TYPE	222	184	99

Figure S170. Get High-res Image Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'AK7 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.271 (Fisher's exact test), Q value = 1

Table S461. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
AK7 MUTATED	3	0	1
AK7 WILD-TYPE	181	162	158

'AK7 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.00095 (Fisher's exact test), Q value = 0.022

Table S462. Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
AK7 MUTATED	0	0	0	4
AK7 WILD-TYPE	90	138	188	85

Figure S171. Get High-res Image Gene #46: 'AK7 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'GAGE2D MUTATION STATUS' versus 'CN_CNMF'

P value = 0.672 (Fisher's exact test), Q value = 1

Table S463. Gene #47: 'GAGE2D MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
GAGE2D MUTATED	1	4	0
GAGE2D WILD-TYPE	294	477	7

'GAGE2D MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S464. Gene #47: 'GAGE2D MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
GAGE2D MUTATED	1	2	0	2
GAGE2D WILD-TYPE	159	230	64	164

'GAGE2D MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.863 (Fisher's exact test), Q value = 1

Table S465. Gene #47: 'GAGE2D MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
GAGE2D MUTATED	1	2	2
GAGE2D WILD-TYPE	226	233	190

'GAGE2D MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.866 (Fisher's exact test), Q value = 1

Table S466. Gene #47: 'GAGE2D MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
GAGE2D MUTATED	1	2	2
GAGE2D WILD-TYPE	195	188	266

'GAGE2D MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.766 (Fisher's exact test), Q value = 1

Table S467. Gene #47: 'GAGE2D MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
GAGE2D MUTATED	1	2	2	0
GAGE2D WILD-TYPE	135	105	181	83

'GAGE2D MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S468. Gene #47: 'GAGE2D MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
GAGE2D MUTATED	2	2	1
GAGE2D WILD-TYPE	220	182	102

'GAGE2D MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.744 (Fisher's exact test), Q value = 1

Table S469. Gene #47: 'GAGE2D MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
GAGE2D MUTATED	1	2	2
GAGE2D WILD-TYPE	183	160	157

'GAGE2D MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.292 (Fisher's exact test), Q value = 1

Table S470. Gene #47: 'GAGE2D MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
GAGE2D MUTATED	2	0	2	1
GAGE2D WILD-TYPE	88	138	186	88

'SETD2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.00573 (Fisher's exact test), Q value = 0.096

Table S471. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
SETD2 MUTATED	0	3	0	0
SETD2 WILD-TYPE	69	40	74	54

Figure S172. Get High-res Image Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

'SETD2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.353 (Fisher's exact test), Q value = 1

Table S472. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
SETD2 MUTATED	2	1	0	0
SETD2 WILD-TYPE	61	49	48	79

'SETD2 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.458 (Fisher's exact test), Q value = 1

Table S473. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
SETD2 MUTATED	1	0	1	1
SETD2 WILD-TYPE	76	93	44	59

'SETD2 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S474. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
SETD2 MUTATED	2	0	1
SETD2 WILD-TYPE	136	61	75

'SETD2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.619 (Fisher's exact test), Q value = 1

Table S475. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SETD2 MUTATED	6	7	0
SETD2 WILD-TYPE	289	474	7

'SETD2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.174 (Fisher's exact test), Q value = 0.87

Table S476. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SETD2 MUTATED	7	3	1	2
SETD2 WILD-TYPE	153	229	63	164

'SETD2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.112 (Fisher's exact test), Q value = 0.68

Table S477. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SETD2 MUTATED	8	2	3
SETD2 WILD-TYPE	219	233	189

'SETD2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.38 (Fisher's exact test), Q value = 1

Table S478. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SETD2 MUTATED	5	5	3
SETD2 WILD-TYPE	191	185	265

'SETD2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.605 (Fisher's exact test), Q value = 1

Table S479. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SETD2 MUTATED	2	4	3	1
SETD2 WILD-TYPE	134	103	180	82

'SETD2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0912 (Fisher's exact test), Q value = 0.6

Table S480. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SETD2 MUTATED	3	2	5
SETD2 WILD-TYPE	219	182	98

'SETD2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.853 (Fisher's exact test), Q value = 1

Table S481. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SETD2 MUTATED	3	3	4
SETD2 WILD-TYPE	181	159	155

'SETD2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.378 (Fisher's exact test), Q value = 1

Table S482. Gene #48: 'SETD2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SETD2 MUTATED	1	2	3	4
SETD2 WILD-TYPE	89	136	185	85

'HDAC2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S483. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
HDAC2 MUTATED	1	0	1	1
HDAC2 WILD-TYPE	68	43	73	53

'HDAC2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.184 (Fisher's exact test), Q value = 0.9

Table S484. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
HDAC2 MUTATED	0	0	0	3
HDAC2 WILD-TYPE	63	50	48	76

'HDAC2 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.459 (Fisher's exact test), Q value = 1

Table S485. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
HDAC2 MUTATED	1	0	1	1
HDAC2 WILD-TYPE	76	93	44	59

'HDAC2 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.194 (Fisher's exact test), Q value = 0.9

Table S486. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
HDAC2 MUTATED	1	2	0
HDAC2 WILD-TYPE	137	59	76

'HDAC2 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S487. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
HDAC2 MUTATED	3	4	0
HDAC2 WILD-TYPE	292	477	7

'HDAC2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.166 (Fisher's exact test), Q value = 0.85

Table S488. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
HDAC2 MUTATED	2	0	0	3
HDAC2 WILD-TYPE	158	232	64	163

'HDAC2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.599 (Fisher's exact test), Q value = 1

Table S489. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
HDAC2 MUTATED	3	1	2
HDAC2 WILD-TYPE	224	234	190

'HDAC2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.886 (Fisher's exact test), Q value = 1

Table S490. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
HDAC2 MUTATED	2	1	3
HDAC2 WILD-TYPE	194	189	265

'HDAC2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.217 (Fisher's exact test), Q value = 0.92

Table S491. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
HDAC2 MUTATED	0	1	1	2
HDAC2 WILD-TYPE	136	106	182	81

'HDAC2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.682 (Fisher's exact test), Q value = 1

Table S492. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
HDAC2 MUTATED	1	2	1
HDAC2 WILD-TYPE	221	182	102

'HDAC2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.162 (Fisher's exact test), Q value = 0.84

Table S493. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
HDAC2 MUTATED	1	0	3
HDAC2 WILD-TYPE	183	162	156

'HDAC2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.162 (Fisher's exact test), Q value = 0.84

Table S494. Gene #49: 'HDAC2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
HDAC2 MUTATED	0	0	4	0
HDAC2 WILD-TYPE	90	138	184	89

'TYRP1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S495. Gene #50: 'TYRP1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TYRP1 MUTATED	2	4	0
TYRP1 WILD-TYPE	293	477	7

'TYRP1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.923 (Fisher's exact test), Q value = 1

Table S496. Gene #50: 'TYRP1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TYRP1 MUTATED	2	2	0	1
TYRP1 WILD-TYPE	158	230	64	165

'TYRP1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.781 (Fisher's exact test), Q value = 1

Table S497. Gene #50: 'TYRP1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TYRP1 MUTATED	3	2	1
TYRP1 WILD-TYPE	224	233	191

'TYRP1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.389 (Fisher's exact test), Q value = 1

Table S498. Gene #50: 'TYRP1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TYRP1 MUTATED	2	3	1
TYRP1 WILD-TYPE	194	187	267

'TYRP1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.401 (Fisher's exact test), Q value = 1

Table S499. Gene #50: 'TYRP1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TYRP1 MUTATED	0	2	2	0
TYRP1 WILD-TYPE	136	105	181	83

'TYRP1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.342 (Fisher's exact test), Q value = 1

Table S500. Gene #50: 'TYRP1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TYRP1 MUTATED	1	1	2
TYRP1 WILD-TYPE	221	183	101

'TYRP1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.694 (Fisher's exact test), Q value = 1

Table S501. Gene #50: 'TYRP1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TYRP1 MUTATED	1	1	2
TYRP1 WILD-TYPE	183	161	157

'TYRP1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.357 (Fisher's exact test), Q value = 1

Table S502. Gene #50: 'TYRP1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TYRP1 MUTATED	0	0	3	1
TYRP1 WILD-TYPE	90	138	185	88

'BCOR MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.642 (Fisher's exact test), Q value = 1

Table S503. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
BCOR MUTATED	1	1	2	3
BCOR WILD-TYPE	68	42	72	51

'BCOR MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.359 (Fisher's exact test), Q value = 1

Table S504. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
BCOR MUTATED	0	2	2	3
BCOR WILD-TYPE	63	48	46	76

'BCOR MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.103 (Fisher's exact test), Q value = 0.65

Table S505. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
BCOR MUTATED	0	2	3	2
BCOR WILD-TYPE	77	91	42	58

'BCOR MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.609 (Fisher's exact test), Q value = 1

Table S506. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
BCOR MUTATED	5	1	1
BCOR WILD-TYPE	133	60	75

'BCOR MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S507. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
BCOR MUTATED	8	14	0
BCOR WILD-TYPE	287	467	7

'BCOR MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.652 (Fisher's exact test), Q value = 1

Table S508. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
BCOR MUTATED	4	5	1	7
BCOR WILD-TYPE	156	227	63	159

'BCOR MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.279 (Fisher's exact test), Q value = 1

Table S509. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
BCOR MUTATED	5	4	8
BCOR WILD-TYPE	222	231	184

'BCOR MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.363 (Fisher's exact test), Q value = 1

Table S510. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
BCOR MUTATED	3	4	10
BCOR WILD-TYPE	193	186	258

'BCOR MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.792 (Fisher's exact test), Q value = 1

Table S511. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
BCOR MUTATED	5	3	6	1
BCOR WILD-TYPE	131	104	177	82

'BCOR MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.582 (Fisher's exact test), Q value = 1

Table S512. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
BCOR MUTATED	5	6	4
BCOR WILD-TYPE	217	178	99

'BCOR MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.722 (Fisher's exact test), Q value = 1

Table S513. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
BCOR MUTATED	4	6	5
BCOR WILD-TYPE	180	156	154

'BCOR MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.951 (Fisher's exact test), Q value = 1

Table S514. Gene #51: 'BCOR MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
BCOR MUTATED	2	5	6	2
BCOR WILD-TYPE	88	133	182	87

'PDGFRA MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.0203 (Fisher's exact test), Q value = 0.24

Table S515. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
PDGFRA MUTATED	1	6	3	1
PDGFRA WILD-TYPE	68	37	71	53

Figure S173. Get High-res Image Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

'PDGFRA MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.134 (Fisher's exact test), Q value = 0.76

Table S516. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
PDGFRA MUTATED	1	5	3	2
PDGFRA WILD-TYPE	62	45	45	77

'PDGFRA MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.76 (Fisher's exact test), Q value = 1

Table S517. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PDGFRA MUTATED	5	3	2	2
PDGFRA WILD-TYPE	72	90	43	58

'PDGFRA MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.0924 (Fisher's exact test), Q value = 0.6

Table S518. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PDGFRA MUTATED	10	1	1
PDGFRA WILD-TYPE	128	60	75

'PDGFRA MUTATION STATUS' versus 'CN_CNMF'

P value = 0.477 (Fisher's exact test), Q value = 1

Table S519. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PDGFRA MUTATED	10	11	0
PDGFRA WILD-TYPE	285	470	7

'PDGFRA MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.155 (Fisher's exact test), Q value = 0.83

Table S520. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PDGFRA MUTATED	7	4	0	2
PDGFRA WILD-TYPE	153	228	64	164

'PDGFRA MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.00146 (Fisher's exact test), Q value = 0.032

Table S521. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PDGFRA MUTATED	13	3	1
PDGFRA WILD-TYPE	214	232	191

Figure S174. Get High-res Image Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'PDGFRA MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0148 (Fisher's exact test), Q value = 0.19

Table S522. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PDGFRA MUTATED	10	5	2
PDGFRA WILD-TYPE	186	185	266

Figure S175. Get High-res Image Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'PDGFRA MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 7e-04 (Fisher's exact test), Q value = 0.017

Table S523. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PDGFRA MUTATED	1	7	0	2
PDGFRA WILD-TYPE	135	100	183	81

Figure S176. Get High-res Image Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'PDGFRA MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0013 (Fisher's exact test), Q value = 0.028

Table S524. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PDGFRA MUTATED	2	1	7
PDGFRA WILD-TYPE	220	183	96

Figure S177. Get High-res Image Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'PDGFRA MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.854 (Fisher's exact test), Q value = 1

Table S525. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PDGFRA MUTATED	3	3	4
PDGFRA WILD-TYPE	181	159	155

'PDGFRA MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.186 (Fisher's exact test), Q value = 0.9

Table S526. Gene #52: 'PDGFRA MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PDGFRA MUTATED	0	2	4	4
PDGFRA WILD-TYPE	90	136	184	85

'FAM47C MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.484 (Fisher's exact test), Q value = 1

Table S527. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
FAM47C MUTATED	0	0	2	1
FAM47C WILD-TYPE	69	43	72	53

'FAM47C MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0583 (Fisher's exact test), Q value = 0.45

Table S528. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
FAM47C MUTATED	0	1	2	0
FAM47C WILD-TYPE	63	49	46	79

'FAM47C MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.406 (Fisher's exact test), Q value = 1

Table S529. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
FAM47C MUTATED	1	2	2	0
FAM47C WILD-TYPE	76	91	43	60

'FAM47C MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.843 (Fisher's exact test), Q value = 1

Table S530. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
FAM47C MUTATED	2	1	2
FAM47C WILD-TYPE	136	60	74

'FAM47C MUTATION STATUS' versus 'CN_CNMF'

P value = 0.331 (Fisher's exact test), Q value = 1

Table S531. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
FAM47C MUTATED	5	17	0
FAM47C WILD-TYPE	290	464	7

'FAM47C MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.543 (Fisher's exact test), Q value = 1

Table S532. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
FAM47C MUTATED	3	7	3	7
FAM47C WILD-TYPE	157	225	61	159

'FAM47C MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0509 (Fisher's exact test), Q value = 0.43

Table S533. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
FAM47C MUTATED	5	4	11
FAM47C WILD-TYPE	222	231	181

'FAM47C MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00462 (Fisher's exact test), Q value = 0.081

Table S534. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
FAM47C MUTATED	4	1	15
FAM47C WILD-TYPE	192	189	253

Figure S178. Get High-res Image Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'FAM47C MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.611 (Fisher's exact test), Q value = 1

Table S535. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
FAM47C MUTATED	3	4	9	2
FAM47C WILD-TYPE	133	103	174	81

'FAM47C MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0923 (Fisher's exact test), Q value = 0.6

Table S536. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
FAM47C MUTATED	5	11	2
FAM47C WILD-TYPE	217	173	101

'FAM47C MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.00815 (Fisher's exact test), Q value = 0.12

Table S537. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
FAM47C MUTATED	3	3	12
FAM47C WILD-TYPE	181	159	147

Figure S179. Get High-res Image Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'FAM47C MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.00356 (Fisher's exact test), Q value = 0.065

Table S538. Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
FAM47C MUTATED	0	3	14	1
FAM47C WILD-TYPE	90	135	174	88

Figure S180. Get High-res Image Gene #53: 'FAM47C MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'NEU2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.218 (Fisher's exact test), Q value = 0.92

Table S539. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
NEU2 MUTATED	1	0	0	2
NEU2 WILD-TYPE	68	43	74	52

'NEU2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.548 (Fisher's exact test), Q value = 1

Table S540. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
NEU2 MUTATED	0	1	0	2
NEU2 WILD-TYPE	63	49	48	77

'NEU2 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.781 (Fisher's exact test), Q value = 1

Table S541. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
NEU2 MUTATED	1	1	1	0
NEU2 WILD-TYPE	76	92	44	60

'NEU2 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S542. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
NEU2 MUTATED	2	0	1
NEU2 WILD-TYPE	136	61	75

'NEU2 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S543. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
NEU2 MUTATED	3	5	0
NEU2 WILD-TYPE	292	476	7

'NEU2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.849 (Fisher's exact test), Q value = 1

Table S544. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
NEU2 MUTATED	1	3	0	1
NEU2 WILD-TYPE	159	229	64	165

'NEU2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S545. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
NEU2 MUTATED	2	3	2
NEU2 WILD-TYPE	225	232	190

'NEU2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.347 (Fisher's exact test), Q value = 1

Table S546. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
NEU2 MUTATED	3	3	1
NEU2 WILD-TYPE	193	187	267

'NEU2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.304 (Fisher's exact test), Q value = 1

Table S547. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
NEU2 MUTATED	0	1	2	2
NEU2 WILD-TYPE	136	106	181	81

'NEU2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S548. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
NEU2 MUTATED	2	2	1
NEU2 WILD-TYPE	220	182	102

'NEU2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.458 (Fisher's exact test), Q value = 1

Table S549. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
NEU2 MUTATED	1	1	3
NEU2 WILD-TYPE	183	161	156

'NEU2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.712 (Fisher's exact test), Q value = 1

Table S550. Gene #54: 'NEU2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
NEU2 MUTATED	0	1	3	1
NEU2 WILD-TYPE	90	137	185	88

'SERPING1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.651 (Fisher's exact test), Q value = 1

Table S551. Gene #55: 'SERPING1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SERPING1 MUTATED	2	2	0
SERPING1 WILD-TYPE	293	479	7

'SERPING1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.802 (Fisher's exact test), Q value = 1

Table S552. Gene #55: 'SERPING1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SERPING1 MUTATED	2	1	0	1
SERPING1 WILD-TYPE	158	231	64	165

'SERPING1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.296 (Fisher's exact test), Q value = 1

Table S553. Gene #55: 'SERPING1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SERPING1 MUTATED	0	1	2
SERPING1 WILD-TYPE	227	234	190

'SERPING1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.634 (Fisher's exact test), Q value = 1

Table S554. Gene #55: 'SERPING1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SERPING1 MUTATED	0	1	2
SERPING1 WILD-TYPE	196	189	266

'SERPING1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.678 (Fisher's exact test), Q value = 1

Table S555. Gene #55: 'SERPING1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SERPING1 MUTATED	0	1	2	0
SERPING1 WILD-TYPE	136	106	181	83

'SERPING1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.6 (Fisher's exact test), Q value = 1

Table S556. Gene #55: 'SERPING1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SERPING1 MUTATED	1	2	0
SERPING1 WILD-TYPE	221	182	103

'SERPING1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.412 (Fisher's exact test), Q value = 1

Table S557. Gene #55: 'SERPING1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SERPING1 MUTATED	1	0	2
SERPING1 WILD-TYPE	183	162	157

'SERPING1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.586 (Fisher's exact test), Q value = 1

Table S558. Gene #55: 'SERPING1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SERPING1 MUTATED	1	0	2	0
SERPING1 WILD-TYPE	89	138	186	89

'HTRA2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.199 (Fisher's exact test), Q value = 0.9

Table S559. Gene #56: 'HTRA2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
HTRA2 MUTATED	0	5	0
HTRA2 WILD-TYPE	295	476	7

'HTRA2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.407 (Fisher's exact test), Q value = 1

Table S560. Gene #56: 'HTRA2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
HTRA2 MUTATED	0	3	1	1
HTRA2 WILD-TYPE	160	229	63	165

'HTRA2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.863 (Fisher's exact test), Q value = 1

Table S561. Gene #56: 'HTRA2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
HTRA2 MUTATED	1	2	2
HTRA2 WILD-TYPE	226	233	190

'HTRA2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.869 (Fisher's exact test), Q value = 1

Table S562. Gene #56: 'HTRA2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
HTRA2 MUTATED	1	2	2
HTRA2 WILD-TYPE	195	188	266

'HTRA2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.347 (Fisher's exact test), Q value = 1

Table S563. Gene #56: 'HTRA2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
HTRA2 MUTATED	3	0	1	1
HTRA2 WILD-TYPE	133	107	182	82

'HTRA2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.726 (Fisher's exact test), Q value = 1

Table S564. Gene #56: 'HTRA2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
HTRA2 MUTATED	3	2	0
HTRA2 WILD-TYPE	219	182	103

'HTRA2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.556 (Fisher's exact test), Q value = 1

Table S565. Gene #56: 'HTRA2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
HTRA2 MUTATED	2	2	0
HTRA2 WILD-TYPE	182	160	159

'HTRA2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.471 (Fisher's exact test), Q value = 1

Table S566. Gene #56: 'HTRA2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
HTRA2 MUTATED	2	1	1	0
HTRA2 WILD-TYPE	88	137	187	89

'NOTCH2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.784 (Fisher's exact test), Q value = 1

Table S567. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
NOTCH2 MUTATED	1	0	2	0
NOTCH2 WILD-TYPE	68	43	72	54

'NOTCH2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.223 (Fisher's exact test), Q value = 0.92

Table S568. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
NOTCH2 MUTATED	0	0	2	1
NOTCH2 WILD-TYPE	63	50	46	78

'NOTCH2 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.0601 (Fisher's exact test), Q value = 0.46

Table S569. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
NOTCH2 MUTATED	4	0	0	1
NOTCH2 WILD-TYPE	73	93	45	59

'NOTCH2 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.017 (Fisher's exact test), Q value = 0.21

Table S570. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
NOTCH2 MUTATED	0	1	4
NOTCH2 WILD-TYPE	138	60	72

Figure S181. Get High-res Image Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

'NOTCH2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.62 (Fisher's exact test), Q value = 1

Table S571. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
NOTCH2 MUTATED	6	7	0
NOTCH2 WILD-TYPE	289	474	7

'NOTCH2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.409 (Fisher's exact test), Q value = 1

Table S572. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
NOTCH2 MUTATED	4	5	0	1
NOTCH2 WILD-TYPE	156	227	64	165

'NOTCH2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.853 (Fisher's exact test), Q value = 1

Table S573. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
NOTCH2 MUTATED	4	4	2
NOTCH2 WILD-TYPE	223	231	190

'NOTCH2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.237 (Fisher's exact test), Q value = 0.95

Table S574. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
NOTCH2 MUTATED	3	5	2
NOTCH2 WILD-TYPE	193	185	266

'NOTCH2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.212 (Fisher's exact test), Q value = 0.91

Table S575. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
NOTCH2 MUTATED	2	4	1	1
NOTCH2 WILD-TYPE	134	103	182	82

'NOTCH2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0391 (Fisher's exact test), Q value = 0.37

Table S576. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
NOTCH2 MUTATED	5	0	3
NOTCH2 WILD-TYPE	217	184	100

Figure S182. Get High-res Image Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'NOTCH2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.362 (Fisher's exact test), Q value = 1

Table S577. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
NOTCH2 MUTATED	5	2	1
NOTCH2 WILD-TYPE	179	160	158

'NOTCH2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.542 (Fisher's exact test), Q value = 1

Table S578. Gene #57: 'NOTCH2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
NOTCH2 MUTATED	3	2	2	1
NOTCH2 WILD-TYPE	87	136	186	88

'NKD2 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S579. Gene #58: 'NKD2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
NKD2 MUTATED	1	3	0
NKD2 WILD-TYPE	294	478	7

'NKD2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S580. Gene #58: 'NKD2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
NKD2 MUTATED	1	2	0	1
NKD2 WILD-TYPE	159	230	64	165

'NKD2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.397 (Fisher's exact test), Q value = 1

Table S581. Gene #58: 'NKD2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
NKD2 MUTATED	1	3	0
NKD2 WILD-TYPE	226	232	192

'NKD2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S582. Gene #58: 'NKD2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
NKD2 MUTATED	1	1	2
NKD2 WILD-TYPE	195	189	266

'NKD2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.367 (Fisher's exact test), Q value = 1

Table S583. Gene #58: 'NKD2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
NKD2 MUTATED	0	2	1	1
NKD2 WILD-TYPE	136	105	182	82

'NKD2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S584. Gene #58: 'NKD2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
NKD2 MUTATED	2	1	1
NKD2 WILD-TYPE	220	183	102

'NKD2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S585. Gene #58: 'NKD2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
NKD2 MUTATED	2	1	1
NKD2 WILD-TYPE	182	161	158

'NKD2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.838 (Fisher's exact test), Q value = 1

Table S586. Gene #58: 'NKD2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
NKD2 MUTATED	1	1	1	1
NKD2 WILD-TYPE	89	137	187	88

'TPX2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.734 (Fisher's exact test), Q value = 1

Table S587. Gene #59: 'TPX2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TPX2 MUTATED	2	5	0
TPX2 WILD-TYPE	293	476	7

'TPX2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.643 (Fisher's exact test), Q value = 1

Table S588. Gene #59: 'TPX2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TPX2 MUTATED	3	3	0	1
TPX2 WILD-TYPE	157	229	64	165

'TPX2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S589. Gene #59: 'TPX2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TPX2 MUTATED	2	2	2
TPX2 WILD-TYPE	225	233	190

'TPX2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.595 (Fisher's exact test), Q value = 1

Table S590. Gene #59: 'TPX2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TPX2 MUTATED	1	3	2
TPX2 WILD-TYPE	195	187	266

'TPX2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.489 (Fisher's exact test), Q value = 1

Table S591. Gene #59: 'TPX2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TPX2 MUTATED	0	1	3	1
TPX2 WILD-TYPE	136	106	180	82

'TPX2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0718 (Fisher's exact test), Q value = 0.52

Table S592. Gene #59: 'TPX2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TPX2 MUTATED	0	4	1
TPX2 WILD-TYPE	222	180	102

'TPX2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.167 (Fisher's exact test), Q value = 0.85

Table S593. Gene #59: 'TPX2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TPX2 MUTATED	0	2	3
TPX2 WILD-TYPE	184	160	156

'TPX2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.317 (Fisher's exact test), Q value = 1

Table S594. Gene #59: 'TPX2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TPX2 MUTATED	0	1	4	0
TPX2 WILD-TYPE	90	137	184	89

'ZNF512B MUTATION STATUS' versus 'CN_CNMF'

P value = 0.2 (Fisher's exact test), Q value = 0.9

Table S595. Gene #60: 'ZNF512B MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ZNF512B MUTATED	0	5	0
ZNF512B WILD-TYPE	295	476	7

'ZNF512B MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.85 (Fisher's exact test), Q value = 1

Table S596. Gene #60: 'ZNF512B MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ZNF512B MUTATED	1	3	0	1
ZNF512B WILD-TYPE	159	229	64	165

'ZNF512B MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.864 (Fisher's exact test), Q value = 1

Table S597. Gene #60: 'ZNF512B MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ZNF512B MUTATED	1	2	2
ZNF512B WILD-TYPE	226	233	190

'ZNF512B MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.338 (Fisher's exact test), Q value = 1

Table S598. Gene #60: 'ZNF512B MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ZNF512B MUTATED	0	2	3
ZNF512B WILD-TYPE	196	188	265

'ZNF512B MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S599. Gene #60: 'ZNF512B MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ZNF512B MUTATED	1	1	2	1
ZNF512B WILD-TYPE	135	106	181	82

'ZNF512B MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S600. Gene #60: 'ZNF512B MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ZNF512B MUTATED	2	2	1
ZNF512B WILD-TYPE	220	182	102

'ZNF512B MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.456 (Fisher's exact test), Q value = 1

Table S601. Gene #60: 'ZNF512B MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ZNF512B MUTATED	1	1	3
ZNF512B WILD-TYPE	183	161	156

'ZNF512B MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.243 (Fisher's exact test), Q value = 0.96

Table S602. Gene #60: 'ZNF512B MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ZNF512B MUTATED	1	0	4	0
ZNF512B WILD-TYPE	89	138	184	89

'SPTAN1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S603. Gene #61: 'SPTAN1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
SPTAN1 MUTATED	1	1	0	1
SPTAN1 WILD-TYPE	76	92	45	59

'SPTAN1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.791 (Fisher's exact test), Q value = 1

Table S604. Gene #61: 'SPTAN1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
SPTAN1 MUTATED	1	1	1
SPTAN1 WILD-TYPE	137	60	75

'SPTAN1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S605. Gene #61: 'SPTAN1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SPTAN1 MUTATED	3	5	0
SPTAN1 WILD-TYPE	292	476	7

'SPTAN1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.609 (Fisher's exact test), Q value = 1

Table S606. Gene #61: 'SPTAN1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SPTAN1 MUTATED	3	2	0	1
SPTAN1 WILD-TYPE	157	230	64	165

'SPTAN1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S607. Gene #61: 'SPTAN1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SPTAN1 MUTATED	2	2	2
SPTAN1 WILD-TYPE	225	233	190

'SPTAN1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.591 (Fisher's exact test), Q value = 1

Table S608. Gene #61: 'SPTAN1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SPTAN1 MUTATED	1	3	2
SPTAN1 WILD-TYPE	195	187	266

'SPTAN1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.764 (Fisher's exact test), Q value = 1

Table S609. Gene #61: 'SPTAN1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SPTAN1 MUTATED	1	2	2	0
SPTAN1 WILD-TYPE	135	105	181	83

'SPTAN1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.527 (Fisher's exact test), Q value = 1

Table S610. Gene #61: 'SPTAN1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SPTAN1 MUTATED	2	1	2
SPTAN1 WILD-TYPE	220	183	101

'SPTAN1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.455 (Fisher's exact test), Q value = 1

Table S611. Gene #61: 'SPTAN1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SPTAN1 MUTATED	1	1	3
SPTAN1 WILD-TYPE	183	161	156

'SPTAN1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S612. Gene #61: 'SPTAN1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SPTAN1 MUTATED	1	1	2	1
SPTAN1 WILD-TYPE	89	137	186	88

'THRA MUTATION STATUS' versus 'CN_CNMF'

P value = 0.669 (Fisher's exact test), Q value = 1

Table S613. Gene #62: 'THRA MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
THRA MUTATED	1	4	0
THRA WILD-TYPE	294	477	7

'THRA MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.283 (Fisher's exact test), Q value = 1

Table S614. Gene #62: 'THRA MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
THRA MUTATED	2	0	0	2
THRA WILD-TYPE	158	232	64	164

'THRA MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.688 (Fisher's exact test), Q value = 1

Table S615. Gene #62: 'THRA MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
THRA MUTATED	1	1	2
THRA WILD-TYPE	226	234	190

'THRA MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.312 (Fisher's exact test), Q value = 1

Table S616. Gene #62: 'THRA MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
THRA MUTATED	0	1	3
THRA WILD-TYPE	196	189	265

'THRA MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.218 (Fisher's exact test), Q value = 0.92

Table S617. Gene #62: 'THRA MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
THRA MUTATED	0	1	1	2
THRA WILD-TYPE	136	106	182	81

'THRA MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.682 (Fisher's exact test), Q value = 1

Table S618. Gene #62: 'THRA MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
THRA MUTATED	1	2	1
THRA WILD-TYPE	221	182	102

'THRA MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.333 (Fisher's exact test), Q value = 1

Table S619. Gene #62: 'THRA MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
THRA MUTATED	0	2	2
THRA WILD-TYPE	184	160	157

'THRA MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.581 (Fisher's exact test), Q value = 1

Table S620. Gene #62: 'THRA MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
THRA MUTATED	0	1	3	0
THRA WILD-TYPE	90	137	185	89

'RGS3 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.736 (Fisher's exact test), Q value = 1

Table S621. Gene #63: 'RGS3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
RGS3 MUTATED	2	6	0
RGS3 WILD-TYPE	293	475	7

'RGS3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.253 (Fisher's exact test), Q value = 0.99

Table S622. Gene #63: 'RGS3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
RGS3 MUTATED	3	4	0	0
RGS3 WILD-TYPE	157	228	64	166

'RGS3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.8 (Fisher's exact test), Q value = 1

Table S623. Gene #63: 'RGS3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
RGS3 MUTATED	2	2	3
RGS3 WILD-TYPE	225	233	189

'RGS3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.502 (Fisher's exact test), Q value = 1

Table S624. Gene #63: 'RGS3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
RGS3 MUTATED	1	3	3
RGS3 WILD-TYPE	195	187	265

'RGS3 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.215 (Fisher's exact test), Q value = 0.92

Table S625. Gene #63: 'RGS3 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
RGS3 MUTATED	0	2	4	0
RGS3 WILD-TYPE	136	105	179	83

'RGS3 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.756 (Fisher's exact test), Q value = 1

Table S626. Gene #63: 'RGS3 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
RGS3 MUTATED	2	2	2
RGS3 WILD-TYPE	220	182	101

'RGS3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.296 (Fisher's exact test), Q value = 1

Table S627. Gene #63: 'RGS3 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
RGS3 MUTATED	1	1	4
RGS3 WILD-TYPE	183	161	155

'RGS3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.941 (Fisher's exact test), Q value = 1

Table S628. Gene #63: 'RGS3 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
RGS3 MUTATED	1	1	3	1
RGS3 WILD-TYPE	89	137	185	88

'PROKR2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.601 (Fisher's exact test), Q value = 1

Table S629. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
PROKR2 MUTATED	1	0	3	1
PROKR2 WILD-TYPE	68	43	71	53

'PROKR2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.731 (Fisher's exact test), Q value = 1

Table S630. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
PROKR2 MUTATED	1	1	2	1
PROKR2 WILD-TYPE	62	49	46	78

'PROKR2 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.716 (Fisher's exact test), Q value = 1

Table S631. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PROKR2 MUTATED	1	1	1	2
PROKR2 WILD-TYPE	76	92	44	58

'PROKR2 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.183 (Fisher's exact test), Q value = 0.9

Table S632. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PROKR2 MUTATED	1	1	3
PROKR2 WILD-TYPE	137	60	73

'PROKR2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0514 (Fisher's exact test), Q value = 0.43

Table S633. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PROKR2 MUTATED	7	2	0
PROKR2 WILD-TYPE	288	479	7

'PROKR2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.249 (Fisher's exact test), Q value = 0.98

Table S634. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PROKR2 MUTATED	3	2	0	0
PROKR2 WILD-TYPE	157	230	64	166

'PROKR2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0927 (Fisher's exact test), Q value = 0.6

Table S635. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PROKR2 MUTATED	6	1	1
PROKR2 WILD-TYPE	221	234	191

'PROKR2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0388 (Fisher's exact test), Q value = 0.37

Table S636. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PROKR2 MUTATED	6	1	1
PROKR2 WILD-TYPE	190	189	267

Figure S183. Get High-res Image Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'PROKR2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.282 (Fisher's exact test), Q value = 1

Table S637. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PROKR2 MUTATED	0	0	3	0
PROKR2 WILD-TYPE	136	107	180	83

'PROKR2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.795 (Fisher's exact test), Q value = 1

Table S638. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PROKR2 MUTATED	1	1	1
PROKR2 WILD-TYPE	221	183	102

'PROKR2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S639. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PROKR2 MUTATED	1	1	1
PROKR2 WILD-TYPE	183	161	158

'PROKR2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.774 (Fisher's exact test), Q value = 1

Table S640. Gene #64: 'PROKR2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PROKR2 MUTATED	0	1	1	1
PROKR2 WILD-TYPE	90	137	187	88

'SLC6A14 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.881 (Fisher's exact test), Q value = 1

Table S641. Gene #65: 'SLC6A14 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
SLC6A14 MUTATED	1	1	1	0
SLC6A14 WILD-TYPE	68	42	73	54

'SLC6A14 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.48 (Fisher's exact test), Q value = 1

Table S642. Gene #65: 'SLC6A14 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
SLC6A14 MUTATED	1	1	1	0
SLC6A14 WILD-TYPE	62	49	47	79

'SLC6A14 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.833 (Fisher's exact test), Q value = 1

Table S643. Gene #65: 'SLC6A14 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
SLC6A14 MUTATED	2	1	0	1
SLC6A14 WILD-TYPE	75	92	45	59

'SLC6A14 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S644. Gene #65: 'SLC6A14 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
SLC6A14 MUTATED	2	1	1
SLC6A14 WILD-TYPE	136	60	75

'SLC6A14 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.698 (Fisher's exact test), Q value = 1

Table S645. Gene #65: 'SLC6A14 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SLC6A14 MUTATED	3	3	0
SLC6A14 WILD-TYPE	292	478	7

'SLC6A14 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.046 (Fisher's exact test), Q value = 0.41

Table S646. Gene #65: 'SLC6A14 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SLC6A14 MUTATED	3	0	0	0
SLC6A14 WILD-TYPE	157	232	64	166

Figure S184. Get High-res Image Gene #65: 'SLC6A14 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'SLC6A14 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.158 (Fisher's exact test), Q value = 0.84

Table S647. Gene #65: 'SLC6A14 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SLC6A14 MUTATED	3	0	1
SLC6A14 WILD-TYPE	224	235	191

'SLC6A14 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.822 (Fisher's exact test), Q value = 1

Table S648. Gene #65: 'SLC6A14 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SLC6A14 MUTATED	2	1	1
SLC6A14 WILD-TYPE	194	189	267

'MST1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.695 (Fisher's exact test), Q value = 1

Table S649. Gene #66: 'MST1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
MST1 MUTATED	3	3	0
MST1 WILD-TYPE	292	478	7

'MST1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.801 (Fisher's exact test), Q value = 1

Table S650. Gene #66: 'MST1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
MST1 MUTATED	2	1	0	1
MST1 WILD-TYPE	158	231	64	165

'MST1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.536 (Fisher's exact test), Q value = 1

Table S651. Gene #66: 'MST1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
MST1 MUTATED	3	1	1
MST1 WILD-TYPE	224	234	191

'MST1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.619 (Fisher's exact test), Q value = 1

Table S652. Gene #66: 'MST1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
MST1 MUTATED	2	2	1
MST1 WILD-TYPE	194	188	267

'MST1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.593 (Fisher's exact test), Q value = 1

Table S653. Gene #66: 'MST1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
MST1 MUTATED	1	2	1	0
MST1 WILD-TYPE	135	105	182	83

'MST1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.342 (Fisher's exact test), Q value = 1

Table S654. Gene #66: 'MST1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
MST1 MUTATED	1	1	2
MST1 WILD-TYPE	221	183	101

'MST1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.837 (Fisher's exact test), Q value = 1

Table S655. Gene #66: 'MST1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
MST1 MUTATED	1	2	1
MST1 WILD-TYPE	183	160	158

'MST1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.525 (Fisher's exact test), Q value = 1

Table S656. Gene #66: 'MST1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
MST1 MUTATED	1	0	2	1
MST1 WILD-TYPE	89	138	186	88

'NUP210L MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.811 (Fisher's exact test), Q value = 1

Table S657. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
NUP210L MUTATED	1	2	2	1
NUP210L WILD-TYPE	68	41	72	53

'NUP210L MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.425 (Fisher's exact test), Q value = 1

Table S658. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
NUP210L MUTATED	0	2	1	3
NUP210L WILD-TYPE	63	48	47	76

'NUP210L MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.414 (Fisher's exact test), Q value = 1

Table S659. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
NUP210L MUTATED	3	3	2	0
NUP210L WILD-TYPE	74	90	43	60

'NUP210L MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.358 (Fisher's exact test), Q value = 1

Table S660. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
NUP210L MUTATED	5	0	3
NUP210L WILD-TYPE	133	61	73

'NUP210L MUTATION STATUS' versus 'CN_CNMF'

P value = 0.197 (Fisher's exact test), Q value = 0.9

Table S661. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
NUP210L MUTATED	7	4	0
NUP210L WILD-TYPE	288	477	7

'NUP210L MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0127 (Fisher's exact test), Q value = 0.17

Table S662. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
NUP210L MUTATED	7	1	0	1
NUP210L WILD-TYPE	153	231	64	165

Figure S185. Get High-res Image Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'NUP210L MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0167 (Fisher's exact test), Q value = 0.21

Table S663. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
NUP210L MUTATED	6	0	2
NUP210L WILD-TYPE	221	235	190

Figure S186. Get High-res Image Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'NUP210L MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.208 (Fisher's exact test), Q value = 0.9

Table S664. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
NUP210L MUTATED	5	1	2
NUP210L WILD-TYPE	191	189	266

'NUP210L MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.4 (Fisher's exact test), Q value = 1

Table S665. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
NUP210L MUTATED	0	2	2	0
NUP210L WILD-TYPE	136	105	181	83

'NUP210L MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0754 (Fisher's exact test), Q value = 0.53

Table S666. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
NUP210L MUTATED	0	2	2
NUP210L WILD-TYPE	222	182	101

'NUP210L MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.163 (Fisher's exact test), Q value = 0.84

Table S667. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
NUP210L MUTATED	1	0	3
NUP210L WILD-TYPE	183	162	156

'NUP210L MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.356 (Fisher's exact test), Q value = 1

Table S668. Gene #67: 'NUP210L MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
NUP210L MUTATED	0	0	3	1
NUP210L WILD-TYPE	90	138	185	88

'MED9 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S669. Gene #68: 'MED9 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
MED9 MUTATED	1	2	0
MED9 WILD-TYPE	294	479	7

'MED9 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.473 (Fisher's exact test), Q value = 1

Table S670. Gene #68: 'MED9 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
MED9 MUTATED	0	1	1	1
MED9 WILD-TYPE	160	231	63	165

'MED9 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.296 (Fisher's exact test), Q value = 1

Table S671. Gene #68: 'MED9 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
MED9 MUTATED	0	1	2
MED9 WILD-TYPE	227	234	190

'MED9 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S672. Gene #68: 'MED9 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
MED9 MUTATED	1	1	1
MED9 WILD-TYPE	195	189	267

'MED9 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.878 (Fisher's exact test), Q value = 1

Table S673. Gene #68: 'MED9 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
MED9 MUTATED	1	0	2	0
MED9 WILD-TYPE	135	107	181	83

'MED9 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.793 (Fisher's exact test), Q value = 1

Table S674. Gene #68: 'MED9 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
MED9 MUTATED	1	1	1
MED9 WILD-TYPE	221	183	102

'MED9 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.653 (Fisher's exact test), Q value = 1

Table S675. Gene #68: 'MED9 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
MED9 MUTATED	2	0	1
MED9 WILD-TYPE	182	162	158

'MED9 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.508 (Fisher's exact test), Q value = 1

Table S676. Gene #68: 'MED9 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
MED9 MUTATED	0	0	2	1
MED9 WILD-TYPE	90	138	186	88

'ZDHHC4 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.162 (Fisher's exact test), Q value = 0.84

Table S677. Gene #69: 'ZDHHC4 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
ZDHHC4 MUTATED	0	3	0	0
ZDHHC4 WILD-TYPE	77	90	45	60

'ZDHHC4 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S678. Gene #69: 'ZDHHC4 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
ZDHHC4 MUTATED	2	0	1
ZDHHC4 WILD-TYPE	136	61	75

'ZDHHC4 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.184 (Fisher's exact test), Q value = 0.9

Table S679. Gene #69: 'ZDHHC4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ZDHHC4 MUTATED	3	1	0
ZDHHC4 WILD-TYPE	292	480	7

'ZDHHC4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0121 (Fisher's exact test), Q value = 0.17

Table S680. Gene #69: 'ZDHHC4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ZDHHC4 MUTATED	4	0	0	0
ZDHHC4 WILD-TYPE	156	232	64	166

Figure S187. Get High-res Image Gene #69: 'ZDHHC4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'MATK MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.125 (Fisher's exact test), Q value = 0.72

Table S681. Gene #70: 'MATK MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
MATK MUTATED	0	1	2	0
MATK WILD-TYPE	77	92	43	60

'MATK MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S682. Gene #70: 'MATK MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
MATK MUTATED	2	0	1
MATK WILD-TYPE	136	61	75

'MATK MUTATION STATUS' versus 'CN_CNMF'

P value = 0.536 (Fisher's exact test), Q value = 1

Table S683. Gene #70: 'MATK MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
MATK MUTATED	2	7	0
MATK WILD-TYPE	293	474	7

'MATK MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.786 (Fisher's exact test), Q value = 1

Table S684. Gene #70: 'MATK MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
MATK MUTATED	2	2	0	3
MATK WILD-TYPE	158	230	64	163

'MATK MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.799 (Fisher's exact test), Q value = 1

Table S685. Gene #70: 'MATK MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
MATK MUTATED	2	2	3
MATK WILD-TYPE	225	233	189

'MATK MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.432 (Fisher's exact test), Q value = 1

Table S686. Gene #70: 'MATK MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
MATK MUTATED	1	1	5
MATK WILD-TYPE	195	189	263

'MATK MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.433 (Fisher's exact test), Q value = 1

Table S687. Gene #70: 'MATK MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
MATK MUTATED	0	2	3	1
MATK WILD-TYPE	136	105	180	82

'MATK MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.867 (Fisher's exact test), Q value = 1

Table S688. Gene #70: 'MATK MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
MATK MUTATED	2	3	1
MATK WILD-TYPE	220	181	102

'MATK MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.45 (Fisher's exact test), Q value = 1

Table S689. Gene #70: 'MATK MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
MATK MUTATED	1	2	3
MATK WILD-TYPE	183	160	156

'MATK MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.413 (Fisher's exact test), Q value = 1

Table S690. Gene #70: 'MATK MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
MATK MUTATED	0	2	4	0
MATK WILD-TYPE	90	136	184	89

'KDR MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.203 (Fisher's exact test), Q value = 0.9

Table S691. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
KDR MUTATED	1	2	1	4
KDR WILD-TYPE	68	41	73	50

'KDR MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.655 (Fisher's exact test), Q value = 1

Table S692. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
KDR MUTATED	1	3	1	3
KDR WILD-TYPE	62	47	47	76

'KDR MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.278 (Fisher's exact test), Q value = 1

Table S693. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
KDR MUTATED	2	1	3	2
KDR WILD-TYPE	75	92	42	58

'KDR MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.511 (Fisher's exact test), Q value = 1

Table S694. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
KDR MUTATED	6	1	1
KDR WILD-TYPE	132	60	75

'KDR MUTATION STATUS' versus 'CN_CNMF'

P value = 0.193 (Fisher's exact test), Q value = 0.9

Table S695. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
KDR MUTATED	8	5	0
KDR WILD-TYPE	287	476	7

'KDR MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0368 (Fisher's exact test), Q value = 0.36

Table S696. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
KDR MUTATED	6	1	0	1
KDR WILD-TYPE	154	231	64	165

Figure S188. Get High-res Image Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'KDR MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.1 (Fisher's exact test), Q value = 0.64

Table S697. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
KDR MUTATED	4	0	2
KDR WILD-TYPE	223	235	190

'KDR MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.671 (Fisher's exact test), Q value = 1

Table S698. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
KDR MUTATED	3	1	2
KDR WILD-TYPE	193	189	266

'KDR MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.263 (Fisher's exact test), Q value = 1

Table S699. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
KDR MUTATED	0	2	3	0
KDR WILD-TYPE	136	105	180	83

'KDR MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0237 (Fisher's exact test), Q value = 0.26

Table S700. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
KDR MUTATED	0	2	3
KDR WILD-TYPE	222	182	100

Figure S189. Get High-res Image Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'KDR MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.242 (Fisher's exact test), Q value = 0.96

Table S701. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
KDR MUTATED	2	0	3
KDR WILD-TYPE	182	162	156

'KDR MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.196 (Fisher's exact test), Q value = 0.9

Table S702. Gene #71: 'KDR MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
KDR MUTATED	0	0	3	2
KDR WILD-TYPE	90	138	185	87

'WRN MUTATION STATUS' versus 'CN_CNMF'

P value = 0.45 (Fisher's exact test), Q value = 1

Table S703. Gene #72: 'WRN MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
WRN MUTATED	1	5	0
WRN WILD-TYPE	294	476	7

'WRN MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0495 (Fisher's exact test), Q value = 0.42

Table S704. Gene #72: 'WRN MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
WRN MUTATED	1	0	0	4
WRN WILD-TYPE	159	232	64	162

Figure S190. Get High-res Image Gene #72: 'WRN MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'WRN MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S705. Gene #72: 'WRN MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
WRN MUTATED	2	2	2
WRN WILD-TYPE	225	233	190

'WRN MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.517 (Fisher's exact test), Q value = 1

Table S706. Gene #72: 'WRN MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
WRN MUTATED	1	1	4
WRN WILD-TYPE	195	189	264

'WRN MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0561 (Fisher's exact test), Q value = 0.44

Table S707. Gene #72: 'WRN MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
WRN MUTATED	0	1	1	3
WRN WILD-TYPE	136	106	182	80

'WRN MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S708. Gene #72: 'WRN MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
WRN MUTATED	2	2	1
WRN WILD-TYPE	220	182	102

'WRN MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0433 (Fisher's exact test), Q value = 0.4

Table S709. Gene #72: 'WRN MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
WRN MUTATED	0	4	1
WRN WILD-TYPE	184	158	158

Figure S191. Get High-res Image Gene #72: 'WRN MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

'WRN MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.453 (Fisher's exact test), Q value = 1

Table S710. Gene #72: 'WRN MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
WRN MUTATED	0	3	2	0
WRN WILD-TYPE	90	135	186	89

'G6PC MUTATION STATUS' versus 'CN_CNMF'

P value = 0.731 (Fisher's exact test), Q value = 1

Table S711. Gene #73: 'G6PC MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
G6PC MUTATED	2	5	0
G6PC WILD-TYPE	293	476	7

'G6PC MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.279 (Fisher's exact test), Q value = 1

Table S712. Gene #73: 'G6PC MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
G6PC MUTATED	4	1	0	2
G6PC WILD-TYPE	156	231	64	164

'G6PC MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.798 (Fisher's exact test), Q value = 1

Table S713. Gene #73: 'G6PC MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
G6PC MUTATED	2	2	3
G6PC WILD-TYPE	225	233	189

'G6PC MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S714. Gene #73: 'G6PC MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
G6PC MUTATED	2	2	3
G6PC WILD-TYPE	194	188	265

'G6PC MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.428 (Fisher's exact test), Q value = 1

Table S715. Gene #73: 'G6PC MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
G6PC MUTATED	0	2	3	1
G6PC WILD-TYPE	136	105	180	82

'G6PC MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.151 (Fisher's exact test), Q value = 0.82

Table S716. Gene #73: 'G6PC MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
G6PC MUTATED	1	2	3
G6PC WILD-TYPE	221	182	100

'G6PC MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.292 (Fisher's exact test), Q value = 1

Table S717. Gene #73: 'G6PC MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
G6PC MUTATED	1	1	4
G6PC WILD-TYPE	183	161	155

'G6PC MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.763 (Fisher's exact test), Q value = 1

Table S718. Gene #73: 'G6PC MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
G6PC MUTATED	1	1	2	2
G6PC WILD-TYPE	89	137	186	87

'TMEM184A MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S719. Gene #74: 'TMEM184A MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TMEM184A MUTATED	1	2	0
TMEM184A WILD-TYPE	294	479	7

'TMEM184A MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.354 (Fisher's exact test), Q value = 1

Table S720. Gene #74: 'TMEM184A MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TMEM184A MUTATED	1	0	0	2
TMEM184A WILD-TYPE	159	232	64	164

'TMEM184A MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.202 (Fisher's exact test), Q value = 0.9

Table S721. Gene #74: 'TMEM184A MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TMEM184A MUTATED	1	0	2
TMEM184A WILD-TYPE	226	235	190

'TMEM184A MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.784 (Fisher's exact test), Q value = 1

Table S722. Gene #74: 'TMEM184A MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TMEM184A MUTATED	1	0	2
TMEM184A WILD-TYPE	195	190	266

'TMEM184A MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.879 (Fisher's exact test), Q value = 1

Table S723. Gene #74: 'TMEM184A MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TMEM184A MUTATED	1	0	2	0
TMEM184A WILD-TYPE	135	107	181	83

'TMEM184A MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.232 (Fisher's exact test), Q value = 0.95

Table S724. Gene #74: 'TMEM184A MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TMEM184A MUTATED	0	2	1
TMEM184A WILD-TYPE	222	182	102

'TMEM184A MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.413 (Fisher's exact test), Q value = 1

Table S725. Gene #74: 'TMEM184A MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TMEM184A MUTATED	1	0	2
TMEM184A WILD-TYPE	183	162	157

'TMEM184A MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.511 (Fisher's exact test), Q value = 1

Table S726. Gene #74: 'TMEM184A MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TMEM184A MUTATED	0	0	2	1
TMEM184A WILD-TYPE	90	138	186	88

'PDHA1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S727. Gene #75: 'PDHA1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PDHA1 MUTATED	2	4	0
PDHA1 WILD-TYPE	293	477	7

'PDHA1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.546 (Fisher's exact test), Q value = 1

Table S728. Gene #75: 'PDHA1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PDHA1 MUTATED	1	1	0	3
PDHA1 WILD-TYPE	159	231	64	163

'PDHA1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.878 (Fisher's exact test), Q value = 1

Table S729. Gene #75: 'PDHA1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PDHA1 MUTATED	2	3	1
PDHA1 WILD-TYPE	225	232	191

'PDHA1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.884 (Fisher's exact test), Q value = 1

Table S730. Gene #75: 'PDHA1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PDHA1 MUTATED	2	1	3
PDHA1 WILD-TYPE	194	189	265

'PDHA1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.928 (Fisher's exact test), Q value = 1

Table S731. Gene #75: 'PDHA1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PDHA1 MUTATED	2	1	2	0
PDHA1 WILD-TYPE	134	106	181	83

'PDHA1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.848 (Fisher's exact test), Q value = 1

Table S732. Gene #75: 'PDHA1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PDHA1 MUTATED	3	1	1
PDHA1 WILD-TYPE	219	183	102

'PDHA1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.531 (Fisher's exact test), Q value = 1

Table S733. Gene #75: 'PDHA1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PDHA1 MUTATED	1	3	1
PDHA1 WILD-TYPE	183	159	158

'PDHA1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.398 (Fisher's exact test), Q value = 1

Table S734. Gene #75: 'PDHA1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PDHA1 MUTATED	0	3	1	1
PDHA1 WILD-TYPE	90	135	187	88

'TMEM229B MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.622 (Fisher's exact test), Q value = 1

Table S735. Gene #76: 'TMEM229B MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
TMEM229B MUTATED	0	1	1	1
TMEM229B WILD-TYPE	69	42	73	53

'TMEM229B MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.415 (Fisher's exact test), Q value = 1

Table S736. Gene #76: 'TMEM229B MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
TMEM229B MUTATED	0	0	1	2
TMEM229B WILD-TYPE	63	50	47	77

'TMEM229B MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.393 (Fisher's exact test), Q value = 1

Table S737. Gene #76: 'TMEM229B MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
TMEM229B MUTATED	0	2	1	0
TMEM229B WILD-TYPE	77	91	44	60

'TMEM229B MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.604 (Fisher's exact test), Q value = 1

Table S738. Gene #76: 'TMEM229B MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
TMEM229B MUTATED	2	1	0
TMEM229B WILD-TYPE	136	60	76

'TMEM229B MUTATION STATUS' versus 'CN_CNMF'

P value = 0.186 (Fisher's exact test), Q value = 0.9

Table S739. Gene #76: 'TMEM229B MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TMEM229B MUTATED	3	1	0
TMEM229B WILD-TYPE	292	480	7

'TMEM229B MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0455 (Fisher's exact test), Q value = 0.4

Table S740. Gene #76: 'TMEM229B MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TMEM229B MUTATED	3	0	0	0
TMEM229B WILD-TYPE	157	232	64	166

Figure S192. Get High-res Image Gene #76: 'TMEM229B MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'CD44 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.701 (Fisher's exact test), Q value = 1

Table S741. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
CD44 MUTATED	2	0	1	0
CD44 WILD-TYPE	67	43	73	54

'CD44 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.265 (Fisher's exact test), Q value = 1

Table S742. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
CD44 MUTATED	2	0	1	0
CD44 WILD-TYPE	61	50	47	79

'CD44 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.289 (Fisher's exact test), Q value = 1

Table S743. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
CD44 MUTATED	0	1	0	2
CD44 WILD-TYPE	77	92	45	58

'CD44 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.79 (Fisher's exact test), Q value = 1

Table S744. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
CD44 MUTATED	1	1	1
CD44 WILD-TYPE	137	60	75

'CD44 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.695 (Fisher's exact test), Q value = 1

Table S745. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CD44 MUTATED	3	3	0
CD44 WILD-TYPE	292	478	7

'CD44 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S746. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CD44 MUTATED	1	1	0	1
CD44 WILD-TYPE	159	231	64	165

'CD44 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.202 (Fisher's exact test), Q value = 0.9

Table S747. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CD44 MUTATED	1	0	2
CD44 WILD-TYPE	226	235	190

'CD44 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.632 (Fisher's exact test), Q value = 1

Table S748. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CD44 MUTATED	0	1	2
CD44 WILD-TYPE	196	189	266

'CD44 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.68 (Fisher's exact test), Q value = 1

Table S749. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CD44 MUTATED	0	1	2	0
CD44 WILD-TYPE	136	106	181	83

'CD44 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.233 (Fisher's exact test), Q value = 0.95

Table S750. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CD44 MUTATED	0	2	1
CD44 WILD-TYPE	222	182	102

'CD44 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.207 (Fisher's exact test), Q value = 0.9

Table S751. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CD44 MUTATED	0	1	2
CD44 WILD-TYPE	184	161	157

'CD44 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S752. Gene #77: 'CD44 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CD44 MUTATED	0	1	2	0
CD44 WILD-TYPE	90	137	186	89

'BCLAF1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.328 (Fisher's exact test), Q value = 1

Table S753. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
BCLAF1 MUTATED	3	0	2	0
BCLAF1 WILD-TYPE	66	43	72	54

'BCLAF1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.771 (Fisher's exact test), Q value = 1

Table S754. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
BCLAF1 MUTATED	2	0	1	2
BCLAF1 WILD-TYPE	61	50	47	77

'BCLAF1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.628 (Fisher's exact test), Q value = 1

Table S755. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
BCLAF1 MUTATED	2	1	0	2
BCLAF1 WILD-TYPE	75	92	45	58

'BCLAF1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.425 (Fisher's exact test), Q value = 1

Table S756. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
BCLAF1 MUTATED	4	1	0
BCLAF1 WILD-TYPE	134	60	76

'BCLAF1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.451 (Fisher's exact test), Q value = 1

Table S757. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
BCLAF1 MUTATED	6	6	0
BCLAF1 WILD-TYPE	289	475	7

'BCLAF1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.173 (Fisher's exact test), Q value = 0.87

Table S758. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
BCLAF1 MUTATED	1	5	0	0
BCLAF1 WILD-TYPE	159	227	64	166

'BCLAF1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.104 (Fisher's exact test), Q value = 0.65

Table S759. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
BCLAF1 MUTATED	4	5	0
BCLAF1 WILD-TYPE	223	230	192

'BCLAF1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00544 (Fisher's exact test), Q value = 0.094

Table S760. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
BCLAF1 MUTATED	3	6	0
BCLAF1 WILD-TYPE	193	184	268

Figure S193. Get High-res Image Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'BCLAF1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.267 (Fisher's exact test), Q value = 1

Table S761. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
BCLAF1 MUTATED	2	3	1	0
BCLAF1 WILD-TYPE	134	104	182	83

'BCLAF1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.508 (Fisher's exact test), Q value = 1

Table S762. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
BCLAF1 MUTATED	3	1	2
BCLAF1 WILD-TYPE	219	183	101

'BCLAF1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.33 (Fisher's exact test), Q value = 1

Table S763. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
BCLAF1 MUTATED	1	4	1
BCLAF1 WILD-TYPE	183	158	158

'BCLAF1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.668 (Fisher's exact test), Q value = 1

Table S764. Gene #78: 'BCLAF1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
BCLAF1 MUTATED	2	2	2	0
BCLAF1 WILD-TYPE	88	136	186	89

'POM121 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.447 (Fisher's exact test), Q value = 1

Table S765. Gene #79: 'POM121 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
POM121 MUTATED	1	5	0
POM121 WILD-TYPE	294	476	7

'POM121 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.312 (Fisher's exact test), Q value = 1

Table S766. Gene #79: 'POM121 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
POM121 MUTATED	2	1	1	0
POM121 WILD-TYPE	158	231	63	166

'POM121 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.541 (Fisher's exact test), Q value = 1

Table S767. Gene #79: 'POM121 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
POM121 MUTATED	3	1	1
POM121 WILD-TYPE	224	234	191

'POM121 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.618 (Fisher's exact test), Q value = 1

Table S768. Gene #79: 'POM121 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
POM121 MUTATED	2	2	1
POM121 WILD-TYPE	194	188	267

'POM121 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.589 (Fisher's exact test), Q value = 1

Table S769. Gene #79: 'POM121 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
POM121 MUTATED	1	2	1	0
POM121 WILD-TYPE	135	105	182	83

'POM121 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.34 (Fisher's exact test), Q value = 1

Table S770. Gene #79: 'POM121 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
POM121 MUTATED	1	1	2
POM121 WILD-TYPE	221	183	101

'POM121 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.695 (Fisher's exact test), Q value = 1

Table S771. Gene #79: 'POM121 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
POM121 MUTATED	1	1	2
POM121 WILD-TYPE	183	161	157

'POM121 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.525 (Fisher's exact test), Q value = 1

Table S772. Gene #79: 'POM121 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
POM121 MUTATED	1	0	2	1
POM121 WILD-TYPE	89	138	186	88

'SLC6A3 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.624 (Fisher's exact test), Q value = 1

Table S773. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
SLC6A3 MUTATED	0	1	1	1
SLC6A3 WILD-TYPE	69	42	73	53

'SLC6A3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.702 (Fisher's exact test), Q value = 1

Table S774. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
SLC6A3 MUTATED	0	1	1	1
SLC6A3 WILD-TYPE	63	49	47	78

'SLC6A3 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.396 (Fisher's exact test), Q value = 1

Table S775. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
SLC6A3 MUTATED	0	2	1	0
SLC6A3 WILD-TYPE	77	91	44	60

'SLC6A3 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S776. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
SLC6A3 MUTATED	2	0	1
SLC6A3 WILD-TYPE	136	61	75

'SLC6A3 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.595 (Fisher's exact test), Q value = 1

Table S777. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SLC6A3 MUTATED	3	9	0
SLC6A3 WILD-TYPE	292	472	7

'SLC6A3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.879 (Fisher's exact test), Q value = 1

Table S778. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SLC6A3 MUTATED	3	4	0	3
SLC6A3 WILD-TYPE	157	228	64	163

'SLC6A3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S779. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SLC6A3 MUTATED	3	4	3
SLC6A3 WILD-TYPE	224	231	189

'SLC6A3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.67 (Fisher's exact test), Q value = 1

Table S780. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SLC6A3 MUTATED	2	4	4
SLC6A3 WILD-TYPE	194	186	264

'SLC6A3 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.176 (Fisher's exact test), Q value = 0.87

Table S781. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SLC6A3 MUTATED	2	4	1	2
SLC6A3 WILD-TYPE	134	103	182	81

'SLC6A3 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.508 (Fisher's exact test), Q value = 1

Table S782. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SLC6A3 MUTATED	4	2	3
SLC6A3 WILD-TYPE	218	182	100

'SLC6A3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.704 (Fisher's exact test), Q value = 1

Table S783. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SLC6A3 MUTATED	3	2	4
SLC6A3 WILD-TYPE	181	160	155

'SLC6A3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.533 (Fisher's exact test), Q value = 1

Table S784. Gene #80: 'SLC6A3 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SLC6A3 MUTATED	3	1	4	1
SLC6A3 WILD-TYPE	87	137	184	88

'SMOC1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S785. Gene #81: 'SMOC1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SMOC1 MUTATED	1	3	0
SMOC1 WILD-TYPE	294	478	7

'SMOC1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.193 (Fisher's exact test), Q value = 0.9

Table S786. Gene #81: 'SMOC1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SMOC1 MUTATED	0	2	1	0
SMOC1 WILD-TYPE	160	230	63	166

'SMOC1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S787. Gene #81: 'SMOC1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SMOC1 MUTATED	1	2	1
SMOC1 WILD-TYPE	226	233	191

'SMOC1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.694 (Fisher's exact test), Q value = 1

Table S788. Gene #81: 'SMOC1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SMOC1 MUTATED	1	2	1
SMOC1 WILD-TYPE	195	188	267

'SMOC1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.599 (Fisher's exact test), Q value = 1

Table S789. Gene #81: 'SMOC1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SMOC1 MUTATED	2	0	1	0
SMOC1 WILD-TYPE	134	107	182	83

'SMOC1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S790. Gene #81: 'SMOC1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SMOC1 MUTATED	2	1	0
SMOC1 WILD-TYPE	220	183	103

'SMOC1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.651 (Fisher's exact test), Q value = 1

Table S791. Gene #81: 'SMOC1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SMOC1 MUTATED	2	0	1
SMOC1 WILD-TYPE	182	162	158

'SMOC1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.185 (Fisher's exact test), Q value = 0.9

Table S792. Gene #81: 'SMOC1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SMOC1 MUTATED	2	0	1	0
SMOC1 WILD-TYPE	88	138	187	89

'MYT1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.134 (Fisher's exact test), Q value = 0.76

Table S793. Gene #82: 'MYT1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
MYT1 MUTATED	0	6	0
MYT1 WILD-TYPE	295	475	7

'MYT1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.27 (Fisher's exact test), Q value = 1

Table S794. Gene #82: 'MYT1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
MYT1 MUTATED	1	4	1	0
MYT1 WILD-TYPE	159	228	63	166

'MYT1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.88 (Fisher's exact test), Q value = 1

Table S795. Gene #82: 'MYT1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
MYT1 MUTATED	2	3	1
MYT1 WILD-TYPE	225	232	191

'MYT1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0181 (Fisher's exact test), Q value = 0.22

Table S796. Gene #82: 'MYT1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
MYT1 MUTATED	0	5	1
MYT1 WILD-TYPE	196	185	267

Figure S194. Get High-res Image Gene #82: 'MYT1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'MYT1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.429 (Fisher's exact test), Q value = 1

Table S797. Gene #82: 'MYT1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
MYT1 MUTATED	0	2	3	1
MYT1 WILD-TYPE	136	105	180	82

'MYT1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.758 (Fisher's exact test), Q value = 1

Table S798. Gene #82: 'MYT1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
MYT1 MUTATED	2	2	2
MYT1 WILD-TYPE	220	182	101

'MYT1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.457 (Fisher's exact test), Q value = 1

Table S799. Gene #82: 'MYT1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
MYT1 MUTATED	1	2	3
MYT1 WILD-TYPE	183	160	156

'MYT1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.941 (Fisher's exact test), Q value = 1

Table S800. Gene #82: 'MYT1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
MYT1 MUTATED	1	1	3	1
MYT1 WILD-TYPE	89	137	185	88

'DOCK5 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.261 (Fisher's exact test), Q value = 1

Table S801. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
DOCK5 MUTATED	4	3	1	1
DOCK5 WILD-TYPE	65	40	73	53

'DOCK5 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.908 (Fisher's exact test), Q value = 1

Table S802. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
DOCK5 MUTATED	2	2	1	4
DOCK5 WILD-TYPE	61	48	47	75

'DOCK5 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.0607 (Fisher's exact test), Q value = 0.46

Table S803. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
DOCK5 MUTATED	6	1	0	3
DOCK5 WILD-TYPE	71	92	45	57

'DOCK5 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.3 (Fisher's exact test), Q value = 1

Table S804. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
DOCK5 MUTATED	3	4	3
DOCK5 WILD-TYPE	135	57	73

'DOCK5 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.026 (Fisher's exact test), Q value = 0.28

Table S805. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
DOCK5 MUTATED	13	6	0
DOCK5 WILD-TYPE	282	475	7

Figure S195. Get High-res Image Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'DOCK5 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0337 (Fisher's exact test), Q value = 0.33

Table S806. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
DOCK5 MUTATED	8	4	0	1
DOCK5 WILD-TYPE	152	228	64	165

Figure S196. Get High-res Image Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'DOCK5 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.012 (Fisher's exact test), Q value = 0.17

Table S807. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
DOCK5 MUTATED	12	3	2
DOCK5 WILD-TYPE	215	232	190

Figure S197. Get High-res Image Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'DOCK5 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00608 (Fisher's exact test), Q value = 0.1

Table S808. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
DOCK5 MUTATED	11	4	2
DOCK5 WILD-TYPE	185	186	266

Figure S198. Get High-res Image Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'DOCK5 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0391 (Fisher's exact test), Q value = 0.37

Table S809. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
DOCK5 MUTATED	2	6	2	0
DOCK5 WILD-TYPE	134	101	181	83

Figure S199. Get High-res Image Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'DOCK5 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0667 (Fisher's exact test), Q value = 0.49

Table S810. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
DOCK5 MUTATED	2	3	5
DOCK5 WILD-TYPE	220	181	98

'DOCK5 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.728 (Fisher's exact test), Q value = 1

Table S811. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
DOCK5 MUTATED	4	2	4
DOCK5 WILD-TYPE	180	160	155

'DOCK5 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.461 (Fisher's exact test), Q value = 1

Table S812. Gene #83: 'DOCK5 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
DOCK5 MUTATED	1	1	5	3
DOCK5 WILD-TYPE	89	137	183	86

'SLFN11 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.672 (Fisher's exact test), Q value = 1

Table S813. Gene #84: 'SLFN11 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SLFN11 MUTATED	1	4	0
SLFN11 WILD-TYPE	294	477	7

'SLFN11 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S814. Gene #84: 'SLFN11 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SLFN11 MUTATED	1	2	0	1
SLFN11 WILD-TYPE	159	230	64	165

'SLFN11 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.687 (Fisher's exact test), Q value = 1

Table S815. Gene #84: 'SLFN11 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SLFN11 MUTATED	1	1	2
SLFN11 WILD-TYPE	226	234	190

'SLFN11 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.48 (Fisher's exact test), Q value = 1

Table S816. Gene #84: 'SLFN11 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SLFN11 MUTATED	0	2	2
SLFN11 WILD-TYPE	196	188	266

'SLFN11 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.593 (Fisher's exact test), Q value = 1

Table S817. Gene #84: 'SLFN11 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SLFN11 MUTATED	1	2	1	0
SLFN11 WILD-TYPE	135	105	182	83

'SLFN11 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.265 (Fisher's exact test), Q value = 1

Table S818. Gene #84: 'SLFN11 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SLFN11 MUTATED	3	0	1
SLFN11 WILD-TYPE	219	184	102

'SLFN11 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.475 (Fisher's exact test), Q value = 1

Table S819. Gene #84: 'SLFN11 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SLFN11 MUTATED	2	0	2
SLFN11 WILD-TYPE	182	162	157

'SLFN11 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.76 (Fisher's exact test), Q value = 1

Table S820. Gene #84: 'SLFN11 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SLFN11 MUTATED	0	2	2	0
SLFN11 WILD-TYPE	90	136	186	89

'DLC1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.479 (Fisher's exact test), Q value = 1

Table S821. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
DLC1 MUTATED	0	0	2	1
DLC1 WILD-TYPE	69	43	72	53

'DLC1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0597 (Fisher's exact test), Q value = 0.46

Table S822. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
DLC1 MUTATED	0	1	2	0
DLC1 WILD-TYPE	63	49	46	79

'DLC1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.457 (Fisher's exact test), Q value = 1

Table S823. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
DLC1 MUTATED	1	0	1	1
DLC1 WILD-TYPE	76	93	44	59

'DLC1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.196 (Fisher's exact test), Q value = 0.9

Table S824. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
DLC1 MUTATED	1	2	0
DLC1 WILD-TYPE	137	59	76

'DLC1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.523 (Fisher's exact test), Q value = 1

Table S825. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
DLC1 MUTATED	4	4	0
DLC1 WILD-TYPE	291	477	7

'DLC1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.425 (Fisher's exact test), Q value = 1

Table S826. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
DLC1 MUTATED	4	2	0	1
DLC1 WILD-TYPE	156	230	64	165

'DLC1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.298 (Fisher's exact test), Q value = 1

Table S827. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
DLC1 MUTATED	5	2	1
DLC1 WILD-TYPE	222	233	191

'DLC1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.25 (Fisher's exact test), Q value = 0.98

Table S828. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
DLC1 MUTATED	4	3	1
DLC1 WILD-TYPE	192	187	267

'DLC1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.891 (Fisher's exact test), Q value = 1

Table S829. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
DLC1 MUTATED	1	2	2	1
DLC1 WILD-TYPE	135	105	181	82

'DLC1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.152 (Fisher's exact test), Q value = 0.82

Table S830. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
DLC1 MUTATED	1	2	3
DLC1 WILD-TYPE	221	182	100

'DLC1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.782 (Fisher's exact test), Q value = 1

Table S831. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
DLC1 MUTATED	3	1	2
DLC1 WILD-TYPE	181	161	157

'DLC1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.136 (Fisher's exact test), Q value = 0.77

Table S832. Gene #85: 'DLC1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
DLC1 MUTATED	0	0	4	2
DLC1 WILD-TYPE	90	138	184	87

'PPL MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.306 (Fisher's exact test), Q value = 1

Table S833. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
PPL MUTATED	0	0	1	2
PPL WILD-TYPE	69	43	73	52

'PPL MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.699 (Fisher's exact test), Q value = 1

Table S834. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
PPL MUTATED	0	1	1	1
PPL WILD-TYPE	63	49	47	78

'PPL MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.606 (Fisher's exact test), Q value = 1

Table S835. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PPL MUTATED	0	2	0	1
PPL WILD-TYPE	77	91	45	59

'PPL MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.789 (Fisher's exact test), Q value = 1

Table S836. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PPL MUTATED	1	1	1
PPL WILD-TYPE	137	60	75

'PPL MUTATION STATUS' versus 'CN_CNMF'

P value = 0.737 (Fisher's exact test), Q value = 1

Table S837. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PPL MUTATED	2	6	0
PPL WILD-TYPE	293	475	7

'PPL MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.957 (Fisher's exact test), Q value = 1

Table S838. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PPL MUTATED	2	4	0	2
PPL WILD-TYPE	158	228	64	164

'PPL MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.703 (Fisher's exact test), Q value = 1

Table S839. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PPL MUTATED	4	2	3
PPL WILD-TYPE	223	233	189

'PPL MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.636 (Fisher's exact test), Q value = 1

Table S840. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PPL MUTATED	2	4	3
PPL WILD-TYPE	194	186	265

'PPL MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.145 (Fisher's exact test), Q value = 0.8

Table S841. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PPL MUTATED	0	3	3	0
PPL WILD-TYPE	136	104	180	83

'PPL MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.757 (Fisher's exact test), Q value = 1

Table S842. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PPL MUTATED	2	2	2
PPL WILD-TYPE	220	182	101

'PPL MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.33 (Fisher's exact test), Q value = 1

Table S843. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PPL MUTATED	1	4	1
PPL WILD-TYPE	183	158	158

'PPL MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.729 (Fisher's exact test), Q value = 1

Table S844. Gene #86: 'PPL MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PPL MUTATED	1	3	2	0
PPL WILD-TYPE	89	135	186	89

'CMA1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S845. Gene #87: 'CMA1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CMA1 MUTATED	1	2	0
CMA1 WILD-TYPE	294	479	7

'CMA1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.547 (Fisher's exact test), Q value = 1

Table S846. Gene #87: 'CMA1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CMA1 MUTATED	2	1	0	0
CMA1 WILD-TYPE	158	231	64	166

'PRKCD MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.175 (Fisher's exact test), Q value = 0.87

Table S847. Gene #88: 'PRKCD MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
PRKCD MUTATED	0	2	1	0
PRKCD WILD-TYPE	69	41	73	54

'PRKCD MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0838 (Fisher's exact test), Q value = 0.57

Table S848. Gene #88: 'PRKCD MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
PRKCD MUTATED	0	2	1	0
PRKCD WILD-TYPE	63	48	47	79

'PRKCD MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.162 (Fisher's exact test), Q value = 0.84

Table S849. Gene #88: 'PRKCD MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PRKCD MUTATED	0	3	0	0
PRKCD WILD-TYPE	77	90	45	60

'PRKCD MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S850. Gene #88: 'PRKCD MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PRKCD MUTATED	2	0	1
PRKCD WILD-TYPE	136	61	75

'PRKCD MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00423 (Fisher's exact test), Q value = 0.076

Table S851. Gene #88: 'PRKCD MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PRKCD MUTATED	2	0	1
PRKCD WILD-TYPE	293	481	6

Figure S200. Get High-res Image Gene #88: 'PRKCD MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'ANO1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.477 (Fisher's exact test), Q value = 1

Table S852. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
ANO1 MUTATED	0	0	2	1
ANO1 WILD-TYPE	69	43	72	53

'ANO1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0581 (Fisher's exact test), Q value = 0.45

Table S853. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
ANO1 MUTATED	0	1	2	0
ANO1 WILD-TYPE	63	49	46	79

'ANO1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S854. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
ANO1 MUTATED	1	1	0	1
ANO1 WILD-TYPE	76	92	45	59

'ANO1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.791 (Fisher's exact test), Q value = 1

Table S855. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
ANO1 MUTATED	1	1	1
ANO1 WILD-TYPE	137	60	75

'ANO1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.366 (Fisher's exact test), Q value = 1

Table S856. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ANO1 MUTATED	5	4	0
ANO1 WILD-TYPE	290	477	7

'ANO1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.28 (Fisher's exact test), Q value = 1

Table S857. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ANO1 MUTATED	4	1	0	2
ANO1 WILD-TYPE	156	231	64	164

'ANO1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.577 (Fisher's exact test), Q value = 1

Table S858. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ANO1 MUTATED	4	2	1
ANO1 WILD-TYPE	223	233	191

'ANO1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.887 (Fisher's exact test), Q value = 1

Table S859. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ANO1 MUTATED	3	2	2
ANO1 WILD-TYPE	193	188	266

'ANO1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.732 (Fisher's exact test), Q value = 1

Table S860. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ANO1 MUTATED	2	2	1	1
ANO1 WILD-TYPE	134	105	182	82

'ANO1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.215 (Fisher's exact test), Q value = 0.92

Table S861. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ANO1 MUTATED	2	1	3
ANO1 WILD-TYPE	220	183	100

'ANO1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.685 (Fisher's exact test), Q value = 1

Table S862. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ANO1 MUTATED	2	3	1
ANO1 WILD-TYPE	182	159	158

'ANO1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.64 (Fisher's exact test), Q value = 1

Table S863. Gene #89: 'ANO1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ANO1 MUTATED	0	2	2	2
ANO1 WILD-TYPE	90	136	186	87

'PLXNA3 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.391 (Fisher's exact test), Q value = 1

Table S864. Gene #90: 'PLXNA3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PLXNA3 MUTATED	2	8	0
PLXNA3 WILD-TYPE	293	473	7

'PLXNA3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.35 (Fisher's exact test), Q value = 1

Table S865. Gene #90: 'PLXNA3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PLXNA3 MUTATED	2	2	2	4
PLXNA3 WILD-TYPE	158	230	62	162

'PLXNA3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.44 (Fisher's exact test), Q value = 1

Table S866. Gene #90: 'PLXNA3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PLXNA3 MUTATED	4	5	1
PLXNA3 WILD-TYPE	223	230	191

'PLXNA3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.609 (Fisher's exact test), Q value = 1

Table S867. Gene #90: 'PLXNA3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PLXNA3 MUTATED	3	4	3
PLXNA3 WILD-TYPE	193	186	265

'PLXNA3 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.35 (Fisher's exact test), Q value = 1

Table S868. Gene #90: 'PLXNA3 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PLXNA3 MUTATED	3	3	1	2
PLXNA3 WILD-TYPE	133	104	182	81

'PLXNA3 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.228 (Fisher's exact test), Q value = 0.94

Table S869. Gene #90: 'PLXNA3 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PLXNA3 MUTATED	5	1	3
PLXNA3 WILD-TYPE	217	183	100

'PLXNA3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.483 (Fisher's exact test), Q value = 1

Table S870. Gene #90: 'PLXNA3 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PLXNA3 MUTATED	4	4	1
PLXNA3 WILD-TYPE	180	158	158

'PLXNA3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.875 (Fisher's exact test), Q value = 1

Table S871. Gene #90: 'PLXNA3 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PLXNA3 MUTATED	1	3	3	2
PLXNA3 WILD-TYPE	89	135	185	87

'NAP1L2 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S872. Gene #91: 'NAP1L2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
NAP1L2 MUTATED	2	4	0
NAP1L2 WILD-TYPE	293	477	7

'NAP1L2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.659 (Fisher's exact test), Q value = 1

Table S873. Gene #91: 'NAP1L2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
NAP1L2 MUTATED	0	2	0	2
NAP1L2 WILD-TYPE	160	230	64	164

'NAP1L2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.864 (Fisher's exact test), Q value = 1

Table S874. Gene #91: 'NAP1L2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
NAP1L2 MUTATED	1	2	2
NAP1L2 WILD-TYPE	226	233	190

'NAP1L2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.867 (Fisher's exact test), Q value = 1

Table S875. Gene #91: 'NAP1L2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
NAP1L2 MUTATED	1	2	2
NAP1L2 WILD-TYPE	195	188	266

'NAP1L2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S876. Gene #91: 'NAP1L2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
NAP1L2 MUTATED	1	1	2	0
NAP1L2 WILD-TYPE	135	106	181	83

'NAP1L2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.832 (Fisher's exact test), Q value = 1

Table S877. Gene #91: 'NAP1L2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
NAP1L2 MUTATED	2	2	0
NAP1L2 WILD-TYPE	220	182	103

'NAP1L2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S878. Gene #91: 'NAP1L2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
NAP1L2 MUTATED	2	1	1
NAP1L2 WILD-TYPE	182	161	158

'NAP1L2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S879. Gene #91: 'NAP1L2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
NAP1L2 MUTATED	1	1	2	0
NAP1L2 WILD-TYPE	89	137	186	89

'PLCH2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.695 (Fisher's exact test), Q value = 1

Table S880. Gene #92: 'PLCH2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PLCH2 MUTATED	3	3	0
PLCH2 WILD-TYPE	292	478	7

'PLCH2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.179 (Fisher's exact test), Q value = 0.89

Table S881. Gene #92: 'PLCH2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PLCH2 MUTATED	2	0	1	1
PLCH2 WILD-TYPE	158	232	63	165

'PLCH2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.602 (Fisher's exact test), Q value = 1

Table S882. Gene #92: 'PLCH2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PLCH2 MUTATED	3	1	2
PLCH2 WILD-TYPE	224	234	190

'PLCH2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S883. Gene #92: 'PLCH2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PLCH2 MUTATED	2	2	2
PLCH2 WILD-TYPE	194	188	266

'PLCH2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.912 (Fisher's exact test), Q value = 1

Table S884. Gene #92: 'PLCH2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PLCH2 MUTATED	1	1	1	1
PLCH2 WILD-TYPE	135	106	182	82

'PLCH2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.681 (Fisher's exact test), Q value = 1

Table S885. Gene #92: 'PLCH2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PLCH2 MUTATED	1	2	1
PLCH2 WILD-TYPE	221	182	102

'PLCH2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.694 (Fisher's exact test), Q value = 1

Table S886. Gene #92: 'PLCH2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PLCH2 MUTATED	1	1	2
PLCH2 WILD-TYPE	183	161	157

'PLCH2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.524 (Fisher's exact test), Q value = 1

Table S887. Gene #92: 'PLCH2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PLCH2 MUTATED	1	0	2	1
PLCH2 WILD-TYPE	89	138	186	88

'CD1D MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.878 (Fisher's exact test), Q value = 1

Table S888. Gene #93: 'CD1D MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
CD1D MUTATED	1	1	1	0
CD1D WILD-TYPE	68	42	73	54

'CD1D MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S889. Gene #93: 'CD1D MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
CD1D MUTATED	1	1	0	1
CD1D WILD-TYPE	62	49	48	78

'CD1D MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.642 (Fisher's exact test), Q value = 1

Table S890. Gene #93: 'CD1D MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
CD1D MUTATED	2	2	0	0
CD1D WILD-TYPE	75	91	45	60

'CD1D MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.123 (Fisher's exact test), Q value = 0.72

Table S891. Gene #93: 'CD1D MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
CD1D MUTATED	1	0	3
CD1D WILD-TYPE	137	61	73

'CD1D MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0548 (Fisher's exact test), Q value = 0.43

Table S892. Gene #93: 'CD1D MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CD1D MUTATED	4	0	0
CD1D WILD-TYPE	291	481	7

'CD1D MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.047 (Fisher's exact test), Q value = 0.41

Table S893. Gene #93: 'CD1D MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CD1D MUTATED	3	0	0	0
CD1D WILD-TYPE	157	232	64	166

Figure S201. Get High-res Image Gene #93: 'CD1D MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'UBR3 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.668 (Fisher's exact test), Q value = 1

Table S894. Gene #94: 'UBR3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
UBR3 MUTATED	1	4	0
UBR3 WILD-TYPE	294	477	7

'UBR3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.346 (Fisher's exact test), Q value = 1

Table S895. Gene #94: 'UBR3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
UBR3 MUTATED	0	1	1	2
UBR3 WILD-TYPE	160	231	63	164

'UBR3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0258 (Fisher's exact test), Q value = 0.28

Table S896. Gene #94: 'UBR3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
UBR3 MUTATED	1	0	4
UBR3 WILD-TYPE	226	235	188

Figure S202. Get High-res Image Gene #94: 'UBR3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'UBR3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.234 (Fisher's exact test), Q value = 0.95

Table S897. Gene #94: 'UBR3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
UBR3 MUTATED	1	0	4
UBR3 WILD-TYPE	195	190	264

'UBR3 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.304 (Fisher's exact test), Q value = 1

Table S898. Gene #94: 'UBR3 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
UBR3 MUTATED	0	0	3	1
UBR3 WILD-TYPE	136	107	180	82

'UBR3 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.833 (Fisher's exact test), Q value = 1

Table S899. Gene #94: 'UBR3 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
UBR3 MUTATED	2	2	0
UBR3 WILD-TYPE	220	182	103

'UBR3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.331 (Fisher's exact test), Q value = 1

Table S900. Gene #94: 'UBR3 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
UBR3 MUTATED	0	2	2
UBR3 WILD-TYPE	184	160	157

'UBR3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.759 (Fisher's exact test), Q value = 1

Table S901. Gene #94: 'UBR3 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
UBR3 MUTATED	0	2	2	0
UBR3 WILD-TYPE	90	136	186	89

'CNOT1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.321 (Fisher's exact test), Q value = 1

Table S902. Gene #95: 'CNOT1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CNOT1 MUTATED	1	7	0
CNOT1 WILD-TYPE	294	474	7

'CNOT1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.824 (Fisher's exact test), Q value = 1

Table S903. Gene #95: 'CNOT1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CNOT1 MUTATED	1	4	0	2
CNOT1 WILD-TYPE	159	228	64	164

'CNOT1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.826 (Fisher's exact test), Q value = 1

Table S904. Gene #95: 'CNOT1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CNOT1 MUTATED	3	2	3
CNOT1 WILD-TYPE	224	233	189

'CNOT1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0468 (Fisher's exact test), Q value = 0.41

Table S905. Gene #95: 'CNOT1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CNOT1 MUTATED	0	5	3
CNOT1 WILD-TYPE	196	185	265

Figure S203. Get High-res Image Gene #95: 'CNOT1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'CNOT1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.768 (Fisher's exact test), Q value = 1

Table S906. Gene #95: 'CNOT1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CNOT1 MUTATED	2	2	3	0
CNOT1 WILD-TYPE	134	105	180	83

'CNOT1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.691 (Fisher's exact test), Q value = 1

Table S907. Gene #95: 'CNOT1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CNOT1 MUTATED	2	3	2
CNOT1 WILD-TYPE	220	181	101

'CNOT1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.805 (Fisher's exact test), Q value = 1

Table S908. Gene #95: 'CNOT1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CNOT1 MUTATED	2	2	3
CNOT1 WILD-TYPE	182	160	156

'CNOT1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.679 (Fisher's exact test), Q value = 1

Table S909. Gene #95: 'CNOT1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CNOT1 MUTATED	1	3	3	0
CNOT1 WILD-TYPE	89	135	185	89

'ESR2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.476 (Fisher's exact test), Q value = 1

Table S910. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
ESR2 MUTATED	0	0	2	1
ESR2 WILD-TYPE	69	43	72	53

'ESR2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.702 (Fisher's exact test), Q value = 1

Table S911. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
ESR2 MUTATED	0	1	1	1
ESR2 WILD-TYPE	63	49	47	78

'ESR2 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.779 (Fisher's exact test), Q value = 1

Table S912. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
ESR2 MUTATED	1	1	1	0
ESR2 WILD-TYPE	76	92	44	60

'ESR2 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.437 (Fisher's exact test), Q value = 1

Table S913. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
ESR2 MUTATED	3	0	0
ESR2 WILD-TYPE	135	61	76

'ESR2 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S914. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ESR2 MUTATED	2	3	0
ESR2 WILD-TYPE	293	478	7

'ESR2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.804 (Fisher's exact test), Q value = 1

Table S915. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ESR2 MUTATED	2	1	0	1
ESR2 WILD-TYPE	158	231	64	165

'ESR2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.562 (Fisher's exact test), Q value = 1

Table S916. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ESR2 MUTATED	2	2	0
ESR2 WILD-TYPE	225	233	192

'ESR2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.696 (Fisher's exact test), Q value = 1

Table S917. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ESR2 MUTATED	1	2	1
ESR2 WILD-TYPE	195	188	267

'ESR2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.192 (Fisher's exact test), Q value = 0.9

Table S918. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ESR2 MUTATED	1	2	0	0
ESR2 WILD-TYPE	135	105	183	83

'ESR2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.431 (Fisher's exact test), Q value = 1

Table S919. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ESR2 MUTATED	2	0	1
ESR2 WILD-TYPE	220	184	102

'ESR2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S920. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ESR2 MUTATED	1	1	1
ESR2 WILD-TYPE	183	161	158

'ESR2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S921. Gene #96: 'ESR2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ESR2 MUTATED	0	1	2	0
ESR2 WILD-TYPE	90	137	186	89

'TNFRSF9 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.652 (Fisher's exact test), Q value = 1

Table S922. Gene #97: 'TNFRSF9 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TNFRSF9 MUTATED	2	2	0
TNFRSF9 WILD-TYPE	293	479	7

'TNFRSF9 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0648 (Fisher's exact test), Q value = 0.48

Table S923. Gene #97: 'TNFRSF9 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TNFRSF9 MUTATED	1	1	2	0
TNFRSF9 WILD-TYPE	159	231	62	166

'TNFRSF9 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S924. Gene #97: 'TNFRSF9 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TNFRSF9 MUTATED	1	1	1
TNFRSF9 WILD-TYPE	226	234	191

'TNFRSF9 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S925. Gene #97: 'TNFRSF9 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TNFRSF9 MUTATED	1	1	1
TNFRSF9 WILD-TYPE	195	189	267

'TNFRSF9 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.6 (Fisher's exact test), Q value = 1

Table S926. Gene #97: 'TNFRSF9 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TNFRSF9 MUTATED	2	0	1	0
TNFRSF9 WILD-TYPE	134	107	182	83

'TNFRSF9 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.795 (Fisher's exact test), Q value = 1

Table S927. Gene #97: 'TNFRSF9 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TNFRSF9 MUTATED	1	1	1
TNFRSF9 WILD-TYPE	221	183	102

'TNFRSF9 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.651 (Fisher's exact test), Q value = 1

Table S928. Gene #97: 'TNFRSF9 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TNFRSF9 MUTATED	2	0	1
TNFRSF9 WILD-TYPE	182	162	158

'TNFRSF9 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.514 (Fisher's exact test), Q value = 1

Table S929. Gene #97: 'TNFRSF9 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TNFRSF9 MUTATED	0	0	2	1
TNFRSF9 WILD-TYPE	90	138	186	88

'USP11 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.0383 (Fisher's exact test), Q value = 0.37

Table S930. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
USP11 MUTATED	0	2	0	1
USP11 WILD-TYPE	69	41	74	53

Figure S204. Get High-res Image Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

'USP11 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.306 (Fisher's exact test), Q value = 1

Table S931. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
USP11 MUTATED	0	2	0	1
USP11 WILD-TYPE	63	48	48	78

'USP11 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.0317 (Fisher's exact test), Q value = 0.32

Table S932. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
USP11 MUTATED	0	0	2	1
USP11 WILD-TYPE	77	93	43	59

Figure S205. Get High-res Image Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

'USP11 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.606 (Fisher's exact test), Q value = 1

Table S933. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
USP11 MUTATED	2	1	0
USP11 WILD-TYPE	136	60	76

'USP11 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.772 (Fisher's exact test), Q value = 1

Table S934. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
USP11 MUTATED	3	7	0
USP11 WILD-TYPE	292	474	7

'USP11 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.608 (Fisher's exact test), Q value = 1

Table S935. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
USP11 MUTATED	1	2	1	3
USP11 WILD-TYPE	159	230	63	163

'USP11 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.00988 (Fisher's exact test), Q value = 0.15

Table S936. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
USP11 MUTATED	3	0	6
USP11 WILD-TYPE	224	235	186

Figure S206. Get High-res Image Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'USP11 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.328 (Fisher's exact test), Q value = 1

Table S937. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
USP11 MUTATED	2	1	6
USP11 WILD-TYPE	194	189	262

'USP11 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.202 (Fisher's exact test), Q value = 0.9

Table S938. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
USP11 MUTATED	0	1	5	1
USP11 WILD-TYPE	136	106	178	82

'USP11 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0142 (Fisher's exact test), Q value = 0.19

Table S939. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
USP11 MUTATED	0	6	1
USP11 WILD-TYPE	222	178	102

Figure S207. Get High-res Image Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'USP11 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0629 (Fisher's exact test), Q value = 0.47

Table S940. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
USP11 MUTATED	0	3	4
USP11 WILD-TYPE	184	159	155

'USP11 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0104 (Fisher's exact test), Q value = 0.15

Table S941. Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
USP11 MUTATED	0	0	7	0
USP11 WILD-TYPE	90	138	181	89

Figure S208. Get High-res Image Gene #98: 'USP11 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'CYP11A1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.783 (Fisher's exact test), Q value = 1

Table S942. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
CYP11A1 MUTATED	1	0	2	0
CYP11A1 WILD-TYPE	68	43	72	54

'CYP11A1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.89 (Fisher's exact test), Q value = 1

Table S943. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
CYP11A1 MUTATED	1	0	1	1
CYP11A1 WILD-TYPE	62	50	47	78

'CYP11A1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.875 (Fisher's exact test), Q value = 1

Table S944. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
CYP11A1 MUTATED	1	2	0	0
CYP11A1 WILD-TYPE	76	91	45	60

'CYP11A1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.313 (Fisher's exact test), Q value = 1

Table S945. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
CYP11A1 MUTATED	1	0	2
CYP11A1 WILD-TYPE	137	61	74

'CYP11A1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S946. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CYP11A1 MUTATED	3	4	0
CYP11A1 WILD-TYPE	292	477	7

'CYP11A1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.663 (Fisher's exact test), Q value = 1

Table S947. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CYP11A1 MUTATED	1	1	1	2
CYP11A1 WILD-TYPE	159	231	63	164

'CYP11A1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0415 (Fisher's exact test), Q value = 0.38

Table S948. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CYP11A1 MUTATED	5	0	2
CYP11A1 WILD-TYPE	222	235	190

Figure S209. Get High-res Image Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'CYP11A1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.388 (Fisher's exact test), Q value = 1

Table S949. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CYP11A1 MUTATED	4	1	2
CYP11A1 WILD-TYPE	192	189	266

'CYP11A1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.913 (Fisher's exact test), Q value = 1

Table S950. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CYP11A1 MUTATED	1	1	1	1
CYP11A1 WILD-TYPE	135	106	182	82

'CYP11A1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.684 (Fisher's exact test), Q value = 1

Table S951. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CYP11A1 MUTATED	1	2	1
CYP11A1 WILD-TYPE	221	182	102

'CYP11A1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.838 (Fisher's exact test), Q value = 1

Table S952. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CYP11A1 MUTATED	1	2	1
CYP11A1 WILD-TYPE	183	160	158

'CYP11A1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.238 (Fisher's exact test), Q value = 0.95

Table S953. Gene #99: 'CYP11A1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CYP11A1 MUTATED	0	0	2	2
CYP11A1 WILD-TYPE	90	138	186	87

'NCAPH2 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S954. Gene #100: 'NCAPH2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
NCAPH2 MUTATED	1	3	0
NCAPH2 WILD-TYPE	294	478	7

'NCAPH2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.295 (Fisher's exact test), Q value = 1

Table S955. Gene #100: 'NCAPH2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
NCAPH2 MUTATED	2	0	0	1
NCAPH2 WILD-TYPE	158	232	64	165

'NCAPH2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.401 (Fisher's exact test), Q value = 1

Table S956. Gene #100: 'NCAPH2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
NCAPH2 MUTATED	2	0	1
NCAPH2 WILD-TYPE	225	235	191

'NCAPH2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S957. Gene #100: 'NCAPH2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
NCAPH2 MUTATED	1	1	1
NCAPH2 WILD-TYPE	195	189	267

'PRB3 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S958. Gene #101: 'PRB3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PRB3 MUTATED	1	2	0
PRB3 WILD-TYPE	294	479	7

'PRB3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.411 (Fisher's exact test), Q value = 1

Table S959. Gene #101: 'PRB3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PRB3 MUTATED	1	1	1	0
PRB3 WILD-TYPE	159	231	63	166

'PRB3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.401 (Fisher's exact test), Q value = 1

Table S960. Gene #101: 'PRB3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PRB3 MUTATED	2	0	1
PRB3 WILD-TYPE	225	235	191

'PRB3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S961. Gene #101: 'PRB3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PRB3 MUTATED	1	1	1
PRB3 WILD-TYPE	195	189	267

'TRPV6 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.335 (Fisher's exact test), Q value = 1

Table S962. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
TRPV6 MUTATED	0	2	2	2
TRPV6 WILD-TYPE	69	41	72	52

'TRPV6 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.228 (Fisher's exact test), Q value = 0.94

Table S963. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
TRPV6 MUTATED	0	3	1	2
TRPV6 WILD-TYPE	63	47	47	77

'TRPV6 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.189 (Fisher's exact test), Q value = 0.9

Table S964. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
TRPV6 MUTATED	0	4	2	1
TRPV6 WILD-TYPE	77	89	43	59

'TRPV6 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S965. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
TRPV6 MUTATED	4	1	2
TRPV6 WILD-TYPE	134	60	74

'TRPV6 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.45 (Fisher's exact test), Q value = 1

Table S966. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TRPV6 MUTATED	6	6	0
TRPV6 WILD-TYPE	289	475	7

'TRPV6 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.677 (Fisher's exact test), Q value = 1

Table S967. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TRPV6 MUTATED	3	2	0	2
TRPV6 WILD-TYPE	157	230	64	164

'TRPV6 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0756 (Fisher's exact test), Q value = 0.53

Table S968. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TRPV6 MUTATED	7	1	3
TRPV6 WILD-TYPE	220	234	189

'TRPV6 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.509 (Fisher's exact test), Q value = 1

Table S969. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TRPV6 MUTATED	5	3	3
TRPV6 WILD-TYPE	191	187	265

'TRPV6 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.697 (Fisher's exact test), Q value = 1

Table S970. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TRPV6 MUTATED	1	2	3	0
TRPV6 WILD-TYPE	135	105	180	83

'TRPV6 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.506 (Fisher's exact test), Q value = 1

Table S971. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TRPV6 MUTATED	3	1	2
TRPV6 WILD-TYPE	219	183	101

'TRPV6 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.605 (Fisher's exact test), Q value = 1

Table S972. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TRPV6 MUTATED	2	1	3
TRPV6 WILD-TYPE	182	161	156

'TRPV6 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.497 (Fisher's exact test), Q value = 1

Table S973. Gene #102: 'TRPV6 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TRPV6 MUTATED	0	1	4	1
TRPV6 WILD-TYPE	90	137	184	88

'AOX1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.432 (Fisher's exact test), Q value = 1

Table S974. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
AOX1 MUTATED	0	1	1	2
AOX1 WILD-TYPE	69	42	73	52

'AOX1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.278 (Fisher's exact test), Q value = 1

Table S975. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
AOX1 MUTATED	0	2	0	2
AOX1 WILD-TYPE	63	48	48	77

'AOX1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.118 (Fisher's exact test), Q value = 0.7

Table S976. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
AOX1 MUTATED	0	2	2	0
AOX1 WILD-TYPE	77	91	43	60

'AOX1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.185 (Fisher's exact test), Q value = 0.9

Table S977. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
AOX1 MUTATED	4	0	0
AOX1 WILD-TYPE	134	61	76

'AOX1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.222 (Fisher's exact test), Q value = 0.92

Table S978. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
AOX1 MUTATED	5	3	0
AOX1 WILD-TYPE	290	478	7

'AOX1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.545 (Fisher's exact test), Q value = 1

Table S979. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
AOX1 MUTATED	2	2	0	0
AOX1 WILD-TYPE	158	230	64	166

'AOX1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0915 (Fisher's exact test), Q value = 0.6

Table S980. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
AOX1 MUTATED	6	1	1
AOX1 WILD-TYPE	221	234	191

'AOX1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.105 (Fisher's exact test), Q value = 0.66

Table S981. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
AOX1 MUTATED	5	2	1
AOX1 WILD-TYPE	191	188	267

'AOX1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0439 (Fisher's exact test), Q value = 0.4

Table S982. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
AOX1 MUTATED	1	3	0	0
AOX1 WILD-TYPE	135	104	183	83

Figure S210. Get High-res Image Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'AOX1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0277 (Fisher's exact test), Q value = 0.29

Table S983. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
AOX1 MUTATED	1	0	3
AOX1 WILD-TYPE	221	184	100

Figure S211. Get High-res Image Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'AOX1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.27 (Fisher's exact test), Q value = 1

Table S984. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
AOX1 MUTATED	3	0	1
AOX1 WILD-TYPE	181	162	158

'AOX1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.919 (Fisher's exact test), Q value = 1

Table S985. Gene #103: 'AOX1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
AOX1 MUTATED	0	1	2	1
AOX1 WILD-TYPE	90	137	186	88

'EEF1A1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.397 (Fisher's exact test), Q value = 1

Table S986. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
EEF1A1 MUTATED	1	0	3	0
EEF1A1 WILD-TYPE	68	43	71	54

'EEF1A1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.193 (Fisher's exact test), Q value = 0.9

Table S987. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
EEF1A1 MUTATED	0	0	2	2
EEF1A1 WILD-TYPE	63	50	46	77

'EEF1A1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.536 (Fisher's exact test), Q value = 1

Table S988. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
EEF1A1 MUTATED	0	2	1	1
EEF1A1 WILD-TYPE	77	91	44	59

'EEF1A1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.445 (Fisher's exact test), Q value = 1

Table S989. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
EEF1A1 MUTATED	1	1	2
EEF1A1 WILD-TYPE	137	60	74

'EEF1A1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.125 (Fisher's exact test), Q value = 0.72

Table S990. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
EEF1A1 MUTATED	6	2	0
EEF1A1 WILD-TYPE	289	479	7

'EEF1A1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.47 (Fisher's exact test), Q value = 1

Table S991. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
EEF1A1 MUTATED	3	1	0	1
EEF1A1 WILD-TYPE	157	231	64	165

'EEF1A1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.222 (Fisher's exact test), Q value = 0.92

Table S992. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
EEF1A1 MUTATED	4	2	0
EEF1A1 WILD-TYPE	223	233	192

'EEF1A1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.442 (Fisher's exact test), Q value = 1

Table S993. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
EEF1A1 MUTATED	3	2	1
EEF1A1 WILD-TYPE	193	188	267

'EEF1A1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0214 (Fisher's exact test), Q value = 0.25

Table S994. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
EEF1A1 MUTATED	0	3	0	1
EEF1A1 WILD-TYPE	136	104	183	82

Figure S212. Get High-res Image Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'EEF1A1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.198 (Fisher's exact test), Q value = 0.9

Table S995. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
EEF1A1 MUTATED	2	0	2
EEF1A1 WILD-TYPE	220	184	101

'EEF1A1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S996. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
EEF1A1 MUTATED	2	1	1
EEF1A1 WILD-TYPE	182	161	158

'EEF1A1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.838 (Fisher's exact test), Q value = 1

Table S997. Gene #104: 'EEF1A1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
EEF1A1 MUTATED	1	1	1	1
EEF1A1 WILD-TYPE	89	137	187	88

'ZZZ3 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S998. Gene #105: 'ZZZ3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ZZZ3 MUTATED	1	3	0
ZZZ3 WILD-TYPE	294	478	7

'ZZZ3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.734 (Fisher's exact test), Q value = 1

Table S999. Gene #105: 'ZZZ3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ZZZ3 MUTATED	1	2	0	0
ZZZ3 WILD-TYPE	159	230	64	166

'ZZZ3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.558 (Fisher's exact test), Q value = 1

Table S1000. Gene #105: 'ZZZ3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ZZZ3 MUTATED	2	2	0
ZZZ3 WILD-TYPE	225	233	192

'ZZZ3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0726 (Fisher's exact test), Q value = 0.52

Table S1001. Gene #105: 'ZZZ3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ZZZ3 MUTATED	1	3	0
ZZZ3 WILD-TYPE	195	187	268

'ZZZ3 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.382 (Fisher's exact test), Q value = 1

Table S1002. Gene #105: 'ZZZ3 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ZZZ3 MUTATED	1	1	0	1
ZZZ3 WILD-TYPE	135	106	183	82

'ZZZ3 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.432 (Fisher's exact test), Q value = 1

Table S1003. Gene #105: 'ZZZ3 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ZZZ3 MUTATED	2	0	1
ZZZ3 WILD-TYPE	220	184	102

'ZZZ3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.65 (Fisher's exact test), Q value = 1

Table S1004. Gene #105: 'ZZZ3 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ZZZ3 MUTATED	2	0	1
ZZZ3 WILD-TYPE	182	162	158

'ZZZ3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.887 (Fisher's exact test), Q value = 1

Table S1005. Gene #105: 'ZZZ3 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ZZZ3 MUTATED	1	1	1	0
ZZZ3 WILD-TYPE	89	137	187	89

'PAK1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1006. Gene #106: 'PAK1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PAK1 MUTATED	1	2	0
PAK1 WILD-TYPE	294	479	7

'PAK1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.545 (Fisher's exact test), Q value = 1

Table S1007. Gene #106: 'PAK1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PAK1 MUTATED	2	1	0	0
PAK1 WILD-TYPE	158	231	64	166

'RASGRF2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.695 (Fisher's exact test), Q value = 1

Table S1008. Gene #107: 'RASGRF2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
RASGRF2 MUTATED	3	3	0
RASGRF2 WILD-TYPE	292	478	7

'RASGRF2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.21 (Fisher's exact test), Q value = 0.91

Table S1009. Gene #107: 'RASGRF2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
RASGRF2 MUTATED	4	1	0	1
RASGRF2 WILD-TYPE	156	231	64	165

'RASGRF2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.334 (Fisher's exact test), Q value = 1

Table S1010. Gene #107: 'RASGRF2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
RASGRF2 MUTATED	4	1	1
RASGRF2 WILD-TYPE	223	234	191

'RASGRF2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.67 (Fisher's exact test), Q value = 1

Table S1011. Gene #107: 'RASGRF2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
RASGRF2 MUTATED	3	1	2
RASGRF2 WILD-TYPE	193	189	266

'RASGRF2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0813 (Fisher's exact test), Q value = 0.56

Table S1012. Gene #107: 'RASGRF2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
RASGRF2 MUTATED	0	3	1	0
RASGRF2 WILD-TYPE	136	104	182	83

'RASGRF2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0132 (Fisher's exact test), Q value = 0.18

Table S1013. Gene #107: 'RASGRF2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
RASGRF2 MUTATED	0	1	3
RASGRF2 WILD-TYPE	222	183	100

Figure S213. Get High-res Image Gene #107: 'RASGRF2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'RASGRF2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.84 (Fisher's exact test), Q value = 1

Table S1014. Gene #107: 'RASGRF2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
RASGRF2 MUTATED	1	2	1
RASGRF2 WILD-TYPE	183	160	158

'RASGRF2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.637 (Fisher's exact test), Q value = 1

Table S1015. Gene #107: 'RASGRF2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
RASGRF2 MUTATED	0	2	1	1
RASGRF2 WILD-TYPE	90	136	187	88

'WWC3 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.605 (Fisher's exact test), Q value = 1

Table S1016. Gene #108: 'WWC3 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
WWC3 MUTATED	0	2	0	1
WWC3 WILD-TYPE	77	91	45	59

'WWC3 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.123 (Fisher's exact test), Q value = 0.72

Table S1017. Gene #108: 'WWC3 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
WWC3 MUTATED	0	1	2
WWC3 WILD-TYPE	138	60	74

'WWC3 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1018. Gene #108: 'WWC3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
WWC3 MUTATED	4	7	0
WWC3 WILD-TYPE	291	474	7

'WWC3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.957 (Fisher's exact test), Q value = 1

Table S1019. Gene #108: 'WWC3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
WWC3 MUTATED	2	4	0	2
WWC3 WILD-TYPE	158	228	64	164

'WWC3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.916 (Fisher's exact test), Q value = 1

Table S1020. Gene #108: 'WWC3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
WWC3 MUTATED	3	4	2
WWC3 WILD-TYPE	224	231	190

'WWC3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.635 (Fisher's exact test), Q value = 1

Table S1021. Gene #108: 'WWC3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
WWC3 MUTATED	2	4	3
WWC3 WILD-TYPE	194	186	265

'WWC3 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.738 (Fisher's exact test), Q value = 1

Table S1022. Gene #108: 'WWC3 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
WWC3 MUTATED	1	1	3	2
WWC3 WILD-TYPE	135	106	180	81

'WWC3 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1023. Gene #108: 'WWC3 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
WWC3 MUTATED	3	3	1
WWC3 WILD-TYPE	219	181	102

'WWC3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.804 (Fisher's exact test), Q value = 1

Table S1024. Gene #108: 'WWC3 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
WWC3 MUTATED	2	2	3
WWC3 WILD-TYPE	182	160	156

'WWC3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.241 (Fisher's exact test), Q value = 0.96

Table S1025. Gene #108: 'WWC3 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
WWC3 MUTATED	3	1	3	0
WWC3 WILD-TYPE	87	137	185	89

'TTC30B MUTATION STATUS' versus 'CN_CNMF'

P value = 0.308 (Fisher's exact test), Q value = 1

Table S1026. Gene #109: 'TTC30B MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TTC30B MUTATED	1	6	0
TTC30B WILD-TYPE	294	475	7

'TTC30B MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.646 (Fisher's exact test), Q value = 1

Table S1027. Gene #109: 'TTC30B MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TTC30B MUTATED	1	4	0	1
TTC30B WILD-TYPE	159	228	64	165

'TTC30B MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.635 (Fisher's exact test), Q value = 1

Table S1028. Gene #109: 'TTC30B MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TTC30B MUTATED	2	4	1
TTC30B WILD-TYPE	225	231	191

'TTC30B MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.309 (Fisher's exact test), Q value = 1

Table S1029. Gene #109: 'TTC30B MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TTC30B MUTATED	1	4	2
TTC30B WILD-TYPE	195	186	266

'TTC30B MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0746 (Fisher's exact test), Q value = 0.52

Table S1030. Gene #109: 'TTC30B MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TTC30B MUTATED	1	4	1	0
TTC30B WILD-TYPE	135	103	182	83

'TTC30B MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.666 (Fisher's exact test), Q value = 1

Table S1031. Gene #109: 'TTC30B MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TTC30B MUTATED	4	1	1
TTC30B WILD-TYPE	218	183	102

'TTC30B MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.453 (Fisher's exact test), Q value = 1

Table S1032. Gene #109: 'TTC30B MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TTC30B MUTATED	1	2	3
TTC30B WILD-TYPE	183	160	156

'TTC30B MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.392 (Fisher's exact test), Q value = 1

Table S1033. Gene #109: 'TTC30B MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TTC30B MUTATED	0	3	3	0
TTC30B WILD-TYPE	90	135	185	89

'ROBO3 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.2 (Fisher's exact test), Q value = 0.9

Table S1034. Gene #110: 'ROBO3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ROBO3 MUTATED	0	5	0
ROBO3 WILD-TYPE	295	476	7

'ROBO3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.578 (Fisher's exact test), Q value = 1

Table S1035. Gene #110: 'ROBO3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ROBO3 MUTATED	0	3	0	2
ROBO3 WILD-TYPE	160	229	64	164

'ROBO3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.277 (Fisher's exact test), Q value = 1

Table S1036. Gene #110: 'ROBO3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ROBO3 MUTATED	0	3	2
ROBO3 WILD-TYPE	227	232	190

'ROBO3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.337 (Fisher's exact test), Q value = 1

Table S1037. Gene #110: 'ROBO3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ROBO3 MUTATED	0	2	3
ROBO3 WILD-TYPE	196	188	265

'ROBO3 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.401 (Fisher's exact test), Q value = 1

Table S1038. Gene #110: 'ROBO3 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ROBO3 MUTATED	1	0	2	2
ROBO3 WILD-TYPE	135	107	181	81

'ROBO3 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.29 (Fisher's exact test), Q value = 1

Table S1039. Gene #110: 'ROBO3 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ROBO3 MUTATED	4	1	0
ROBO3 WILD-TYPE	218	183	103

'ROBO3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1040. Gene #110: 'ROBO3 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ROBO3 MUTATED	2	2	1
ROBO3 WILD-TYPE	182	160	158

'ROBO3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.928 (Fisher's exact test), Q value = 1

Table S1041. Gene #110: 'ROBO3 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ROBO3 MUTATED	1	2	2	0
ROBO3 WILD-TYPE	89	136	186	89

'SOX13 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.776 (Fisher's exact test), Q value = 1

Table S1042. Gene #111: 'SOX13 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
SOX13 MUTATED	1	1	1	0
SOX13 WILD-TYPE	76	92	44	60

'SOX13 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1043. Gene #111: 'SOX13 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
SOX13 MUTATED	2	0	1
SOX13 WILD-TYPE	136	61	75

'SOX13 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.115 (Fisher's exact test), Q value = 0.69

Table S1044. Gene #111: 'SOX13 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SOX13 MUTATED	4	1	0
SOX13 WILD-TYPE	291	480	7

'SOX13 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0125 (Fisher's exact test), Q value = 0.17

Table S1045. Gene #111: 'SOX13 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SOX13 MUTATED	4	0	0	0
SOX13 WILD-TYPE	156	232	64	166

Figure S214. Get High-res Image Gene #111: 'SOX13 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'SOX13 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.403 (Fisher's exact test), Q value = 1

Table S1046. Gene #111: 'SOX13 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SOX13 MUTATED	2	0	1
SOX13 WILD-TYPE	225	235	191

'SOX13 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1047. Gene #111: 'SOX13 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SOX13 MUTATED	1	1	1
SOX13 WILD-TYPE	195	189	267

'ST3GAL6 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.401 (Fisher's exact test), Q value = 1

Table S1048. Gene #112: 'ST3GAL6 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ST3GAL6 MUTATED	3	2	0
ST3GAL6 WILD-TYPE	292	479	7

'ST3GAL6 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.296 (Fisher's exact test), Q value = 1

Table S1049. Gene #112: 'ST3GAL6 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ST3GAL6 MUTATED	2	0	0	1
ST3GAL6 WILD-TYPE	158	232	64	165

'ST3GAL6 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0599 (Fisher's exact test), Q value = 0.46

Table S1050. Gene #112: 'ST3GAL6 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ST3GAL6 MUTATED	4	0	1
ST3GAL6 WILD-TYPE	223	235	191

'ST3GAL6 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.527 (Fisher's exact test), Q value = 1

Table S1051. Gene #112: 'ST3GAL6 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ST3GAL6 MUTATED	3	1	1
ST3GAL6 WILD-TYPE	193	189	267

'ST3GAL6 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1052. Gene #112: 'ST3GAL6 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ST3GAL6 MUTATED	1	1	1	0
ST3GAL6 WILD-TYPE	135	106	182	83

'ST3GAL6 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0523 (Fisher's exact test), Q value = 0.43

Table S1053. Gene #112: 'ST3GAL6 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ST3GAL6 MUTATED	0	1	2
ST3GAL6 WILD-TYPE	222	183	101

'ST3GAL6 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.413 (Fisher's exact test), Q value = 1

Table S1054. Gene #112: 'ST3GAL6 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ST3GAL6 MUTATED	1	0	2
ST3GAL6 WILD-TYPE	183	162	157

'ST3GAL6 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.15 (Fisher's exact test), Q value = 0.82

Table S1055. Gene #112: 'ST3GAL6 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ST3GAL6 MUTATED	0	0	1	2
ST3GAL6 WILD-TYPE	90	138	187	87

'CLCN7 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.112 (Fisher's exact test), Q value = 0.68

Table S1056. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
CLCN7 MUTATED	3	1	0	0
CLCN7 WILD-TYPE	66	42	74	54

'CLCN7 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.772 (Fisher's exact test), Q value = 1

Table S1057. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
CLCN7 MUTATED	2	1	0	1
CLCN7 WILD-TYPE	61	49	48	78

'CLCN7 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.697 (Fisher's exact test), Q value = 1

Table S1058. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
CLCN7 MUTATED	1	1	0	2
CLCN7 WILD-TYPE	76	92	45	58

'CLCN7 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.26 (Fisher's exact test), Q value = 1

Table S1059. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
CLCN7 MUTATED	2	2	0
CLCN7 WILD-TYPE	136	59	76

'CLCN7 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.47 (Fisher's exact test), Q value = 1

Table S1060. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CLCN7 MUTATED	4	3	0
CLCN7 WILD-TYPE	291	478	7

'CLCN7 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.846 (Fisher's exact test), Q value = 1

Table S1061. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CLCN7 MUTATED	0	2	0	1
CLCN7 WILD-TYPE	160	230	64	165

'CLCN7 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0737 (Fisher's exact test), Q value = 0.52

Table S1062. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CLCN7 MUTATED	1	0	3
CLCN7 WILD-TYPE	226	235	189

'CLCN7 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.39 (Fisher's exact test), Q value = 1

Table S1063. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CLCN7 MUTATED	1	0	3
CLCN7 WILD-TYPE	195	190	265

'CLCN7 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.679 (Fisher's exact test), Q value = 1

Table S1064. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CLCN7 MUTATED	0	1	2	0
CLCN7 WILD-TYPE	136	106	181	83

'CLCN7 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.793 (Fisher's exact test), Q value = 1

Table S1065. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CLCN7 MUTATED	1	1	1
CLCN7 WILD-TYPE	221	183	102

'CLCN7 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.204 (Fisher's exact test), Q value = 0.9

Table S1066. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CLCN7 MUTATED	0	1	2
CLCN7 WILD-TYPE	184	161	157

'CLCN7 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.671 (Fisher's exact test), Q value = 1

Table S1067. Gene #113: 'CLCN7 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CLCN7 MUTATED	0	2	1	0
CLCN7 WILD-TYPE	90	136	187	89

'CD99L2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.667 (Fisher's exact test), Q value = 1

Table S1068. Gene #114: 'CD99L2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CD99L2 MUTATED	1	4	0
CD99L2 WILD-TYPE	294	477	7

'CD99L2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.2 (Fisher's exact test), Q value = 0.9

Table S1069. Gene #114: 'CD99L2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CD99L2 MUTATED	1	0	1	2
CD99L2 WILD-TYPE	159	232	63	164

'CD99L2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1070. Gene #114: 'CD99L2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CD99L2 MUTATED	2	2	1
CD99L2 WILD-TYPE	225	233	191

'CD99L2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.741 (Fisher's exact test), Q value = 1

Table S1071. Gene #114: 'CD99L2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CD99L2 MUTATED	1	1	3
CD99L2 WILD-TYPE	195	189	265

'CD99L2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.218 (Fisher's exact test), Q value = 0.92

Table S1072. Gene #114: 'CD99L2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CD99L2 MUTATED	0	1	1	2
CD99L2 WILD-TYPE	136	106	182	81

'CD99L2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1073. Gene #114: 'CD99L2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CD99L2 MUTATED	2	1	1
CD99L2 WILD-TYPE	220	183	102

'CD99L2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.693 (Fisher's exact test), Q value = 1

Table S1074. Gene #114: 'CD99L2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CD99L2 MUTATED	1	1	2
CD99L2 WILD-TYPE	183	161	157

'CD99L2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.579 (Fisher's exact test), Q value = 1

Table S1075. Gene #114: 'CD99L2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CD99L2 MUTATED	0	1	3	0
CD99L2 WILD-TYPE	90	137	185	89

'KRAS MUTATION STATUS' versus 'CN_CNMF'

P value = 0.649 (Fisher's exact test), Q value = 1

Table S1076. Gene #115: 'KRAS MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
KRAS MUTATED	2	2	0
KRAS WILD-TYPE	293	479	7

'KRAS MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1077. Gene #115: 'KRAS MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
KRAS MUTATED	1	1	0	1
KRAS WILD-TYPE	159	231	64	165

'KRAS MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1078. Gene #115: 'KRAS MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
KRAS MUTATED	1	1	1
KRAS WILD-TYPE	226	234	191

'KRAS MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.786 (Fisher's exact test), Q value = 1

Table S1079. Gene #115: 'KRAS MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
KRAS MUTATED	1	0	2
KRAS WILD-TYPE	195	190	266

'PRG4 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.391 (Fisher's exact test), Q value = 1

Table S1080. Gene #116: 'PRG4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PRG4 MUTATED	2	8	0
PRG4 WILD-TYPE	293	473	7

'PRG4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1081. Gene #116: 'PRG4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PRG4 MUTATED	2	4	1	3
PRG4 WILD-TYPE	158	228	63	163

'PRG4 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.33 (Fisher's exact test), Q value = 1

Table S1082. Gene #116: 'PRG4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PRG4 MUTATED	1	4	4
PRG4 WILD-TYPE	226	231	188

'PRG4 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.196 (Fisher's exact test), Q value = 0.9

Table S1083. Gene #116: 'PRG4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PRG4 MUTATED	1	5	3
PRG4 WILD-TYPE	195	185	265

'PRG4 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.399 (Fisher's exact test), Q value = 1

Table S1084. Gene #116: 'PRG4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PRG4 MUTATED	4	2	2	0
PRG4 WILD-TYPE	132	105	181	83

'PRG4 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.903 (Fisher's exact test), Q value = 1

Table S1085. Gene #116: 'PRG4 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PRG4 MUTATED	3	3	2
PRG4 WILD-TYPE	219	181	101

'PRG4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.606 (Fisher's exact test), Q value = 1

Table S1086. Gene #116: 'PRG4 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PRG4 MUTATED	2	2	4
PRG4 WILD-TYPE	182	160	155

'PRG4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.72 (Fisher's exact test), Q value = 1

Table S1087. Gene #116: 'PRG4 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PRG4 MUTATED	2	1	3	2
PRG4 WILD-TYPE	88	137	185	87

'USP6 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.93 (Fisher's exact test), Q value = 1

Table S1088. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
USP6 MUTATED	2	1	1	1
USP6 WILD-TYPE	67	42	73	53

'USP6 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1089. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
USP6 MUTATED	1	1	1	2
USP6 WILD-TYPE	62	49	47	77

'USP6 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.404 (Fisher's exact test), Q value = 1

Table S1090. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
USP6 MUTATED	1	2	2	0
USP6 WILD-TYPE	76	91	43	60

'USP6 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.43 (Fisher's exact test), Q value = 1

Table S1091. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
USP6 MUTATED	4	1	0
USP6 WILD-TYPE	134	60	76

'USP6 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.408 (Fisher's exact test), Q value = 1

Table S1092. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
USP6 MUTATED	6	5	0
USP6 WILD-TYPE	289	476	7

'USP6 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.694 (Fisher's exact test), Q value = 1

Table S1093. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
USP6 MUTATED	3	3	1	1
USP6 WILD-TYPE	157	229	63	165

'USP6 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.169 (Fisher's exact test), Q value = 0.86

Table S1094. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
USP6 MUTATED	6	2	1
USP6 WILD-TYPE	221	233	191

'USP6 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.492 (Fisher's exact test), Q value = 1

Table S1095. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
USP6 MUTATED	4	3	2
USP6 WILD-TYPE	192	187	266

'USP6 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.73 (Fisher's exact test), Q value = 1

Table S1096. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
USP6 MUTATED	2	2	1	1
USP6 WILD-TYPE	134	105	182	82

'USP6 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.219 (Fisher's exact test), Q value = 0.92

Table S1097. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
USP6 MUTATED	2	1	3
USP6 WILD-TYPE	220	183	100

'USP6 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1098. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
USP6 MUTATED	2	2	2
USP6 WILD-TYPE	182	160	157

'USP6 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.551 (Fisher's exact test), Q value = 1

Table S1099. Gene #117: 'USP6 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
USP6 MUTATED	1	2	1	2
USP6 WILD-TYPE	89	136	187	87

'TP63 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1100. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
TP63 MUTATED	1	1	2	1
TP63 WILD-TYPE	68	42	72	53

'TP63 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.73 (Fisher's exact test), Q value = 1

Table S1101. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
TP63 MUTATED	1	1	2	1
TP63 WILD-TYPE	62	49	46	78

'TP63 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.407 (Fisher's exact test), Q value = 1

Table S1102. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
TP63 MUTATED	1	1	1	3
TP63 WILD-TYPE	76	92	44	57

'TP63 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.644 (Fisher's exact test), Q value = 1

Table S1103. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
TP63 MUTATED	2	2	2
TP63 WILD-TYPE	136	59	74

'TP63 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.366 (Fisher's exact test), Q value = 1

Table S1104. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TP63 MUTATED	5	4	0
TP63 WILD-TYPE	290	477	7

'TP63 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0616 (Fisher's exact test), Q value = 0.46

Table S1105. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TP63 MUTATED	5	2	0	0
TP63 WILD-TYPE	155	230	64	166

'TP63 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0434 (Fisher's exact test), Q value = 0.4

Table S1106. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TP63 MUTATED	5	1	0
TP63 WILD-TYPE	222	234	192

Figure S215. Get High-res Image Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'TP63 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0568 (Fisher's exact test), Q value = 0.44

Table S1107. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TP63 MUTATED	3	3	0
TP63 WILD-TYPE	193	187	268

'TP63 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.238 (Fisher's exact test), Q value = 0.95

Table S1108. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TP63 MUTATED	2	1	0	0
TP63 WILD-TYPE	134	106	183	83

'TP63 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.429 (Fisher's exact test), Q value = 1

Table S1109. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TP63 MUTATED	2	0	1
TP63 WILD-TYPE	220	184	102

'TP63 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0623 (Fisher's exact test), Q value = 0.47

Table S1110. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TP63 MUTATED	0	3	0
TP63 WILD-TYPE	184	159	159

'TP63 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.263 (Fisher's exact test), Q value = 1

Table S1111. Gene #118: 'TP63 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TP63 MUTATED	1	2	0	0
TP63 WILD-TYPE	89	136	188	89

'OR52M1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.505 (Fisher's exact test), Q value = 1

Table S1112. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
OR52M1 MUTATED	2	1	0	1
OR52M1 WILD-TYPE	67	42	74	53

'OR52M1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.603 (Fisher's exact test), Q value = 1

Table S1113. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
OR52M1 MUTATED	1	2	0	1
OR52M1 WILD-TYPE	62	48	48	78

'OR52M1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.0863 (Fisher's exact test), Q value = 0.58

Table S1114. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
OR52M1 MUTATED	0	1	0	3
OR52M1 WILD-TYPE	77	92	45	57

'OR52M1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.0593 (Fisher's exact test), Q value = 0.46

Table S1115. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
OR52M1 MUTATED	1	3	0
OR52M1 WILD-TYPE	137	58	76

'OR52M1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.224 (Fisher's exact test), Q value = 0.92

Table S1116. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
OR52M1 MUTATED	5	3	0
OR52M1 WILD-TYPE	290	478	7

'OR52M1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.379 (Fisher's exact test), Q value = 1

Table S1117. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
OR52M1 MUTATED	2	2	1	0
OR52M1 WILD-TYPE	158	230	63	166

'OR52M1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.574 (Fisher's exact test), Q value = 1

Table S1118. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
OR52M1 MUTATED	4	2	1
OR52M1 WILD-TYPE	223	233	191

'OR52M1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.271 (Fisher's exact test), Q value = 1

Table S1119. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
OR52M1 MUTATED	4	2	1
OR52M1 WILD-TYPE	192	188	267

'OR52M1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.765 (Fisher's exact test), Q value = 1

Table S1120. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
OR52M1 MUTATED	2	1	1	0
OR52M1 WILD-TYPE	134	106	182	83

'OR52M1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1121. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
OR52M1 MUTATED	2	1	1
OR52M1 WILD-TYPE	220	183	102

'OR52M1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1122. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
OR52M1 MUTATED	2	1	1
OR52M1 WILD-TYPE	182	161	158

'OR52M1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.839 (Fisher's exact test), Q value = 1

Table S1123. Gene #119: 'OR52M1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
OR52M1 MUTATED	1	1	1	1
OR52M1 WILD-TYPE	89	137	187	88

'TNFSF9 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.683 (Fisher's exact test), Q value = 1

Table S1124. Gene #120: 'TNFSF9 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
TNFSF9 MUTATED	2	1	0	0
TNFSF9 WILD-TYPE	75	92	45	60

'TNFSF9 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.308 (Fisher's exact test), Q value = 1

Table S1125. Gene #120: 'TNFSF9 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
TNFSF9 MUTATED	1	0	2
TNFSF9 WILD-TYPE	137	61	74

'TNFSF9 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.402 (Fisher's exact test), Q value = 1

Table S1126. Gene #120: 'TNFSF9 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TNFSF9 MUTATED	3	2	0
TNFSF9 WILD-TYPE	292	479	7

'TNFSF9 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.473 (Fisher's exact test), Q value = 1

Table S1127. Gene #120: 'TNFSF9 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TNFSF9 MUTATED	3	1	0	1
TNFSF9 WILD-TYPE	157	231	64	165

'HEATR3 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.651 (Fisher's exact test), Q value = 1

Table S1128. Gene #121: 'HEATR3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
HEATR3 MUTATED	2	2	0
HEATR3 WILD-TYPE	293	479	7

'HEATR3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.298 (Fisher's exact test), Q value = 1

Table S1129. Gene #121: 'HEATR3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
HEATR3 MUTATED	2	0	0	1
HEATR3 WILD-TYPE	158	232	64	165

'HEATR3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.645 (Fisher's exact test), Q value = 1

Table S1130. Gene #121: 'HEATR3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
HEATR3 MUTATED	2	1	0
HEATR3 WILD-TYPE	225	234	192

'HEATR3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1131. Gene #121: 'HEATR3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
HEATR3 MUTATED	1	1	1
HEATR3 WILD-TYPE	195	189	267

'USP28 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.402 (Fisher's exact test), Q value = 1

Table S1132. Gene #122: 'USP28 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
USP28 MUTATED	3	2	0
USP28 WILD-TYPE	292	479	7

'USP28 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.157 (Fisher's exact test), Q value = 0.84

Table S1133. Gene #122: 'USP28 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
USP28 MUTATED	3	0	1
USP28 WILD-TYPE	224	235	191

'USP28 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.822 (Fisher's exact test), Q value = 1

Table S1134. Gene #122: 'USP28 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
USP28 MUTATED	2	1	1
USP28 WILD-TYPE	194	189	267

'ACADS MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.415 (Fisher's exact test), Q value = 1

Table S1135. Gene #123: 'ACADS MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
ACADS MUTATED	2	0	0	1
ACADS WILD-TYPE	67	43	74	53

'ACADS MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.35 (Fisher's exact test), Q value = 1

Table S1136. Gene #123: 'ACADS MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
ACADS MUTATED	2	1	0	0
ACADS WILD-TYPE	61	49	48	79

'ACADS MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.342 (Fisher's exact test), Q value = 1

Table S1137. Gene #123: 'ACADS MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
ACADS MUTATED	2	0	0	1
ACADS WILD-TYPE	75	93	45	59

'ACADS MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.79 (Fisher's exact test), Q value = 1

Table S1138. Gene #123: 'ACADS MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
ACADS MUTATED	1	1	1
ACADS WILD-TYPE	137	60	75

'ACADS MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00765 (Fisher's exact test), Q value = 0.12

Table S1139. Gene #123: 'ACADS MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ACADS MUTATED	3	1	1
ACADS WILD-TYPE	292	480	6

Figure S216. Get High-res Image Gene #123: 'ACADS MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'ACADS MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0464 (Fisher's exact test), Q value = 0.41

Table S1140. Gene #123: 'ACADS MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ACADS MUTATED	3	0	0	0
ACADS WILD-TYPE	157	232	64	166

Figure S217. Get High-res Image Gene #123: 'ACADS MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'RGL2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.329 (Fisher's exact test), Q value = 1

Table S1141. Gene #124: 'RGL2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
RGL2 MUTATED	0	4	0
RGL2 WILD-TYPE	295	477	7

'RGL2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1142. Gene #124: 'RGL2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
RGL2 MUTATED	1	2	0	1
RGL2 WILD-TYPE	159	230	64	165

'RGL2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1143. Gene #124: 'RGL2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
RGL2 MUTATED	1	2	1
RGL2 WILD-TYPE	226	233	191

'RGL2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.14 (Fisher's exact test), Q value = 0.79

Table S1144. Gene #124: 'RGL2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
RGL2 MUTATED	0	3	1
RGL2 WILD-TYPE	196	187	267

'RGL2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.401 (Fisher's exact test), Q value = 1

Table S1145. Gene #124: 'RGL2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
RGL2 MUTATED	0	2	2	0
RGL2 WILD-TYPE	136	105	181	83

'RGL2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.339 (Fisher's exact test), Q value = 1

Table S1146. Gene #124: 'RGL2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
RGL2 MUTATED	1	1	2
RGL2 WILD-TYPE	221	183	101

'RGL2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.695 (Fisher's exact test), Q value = 1

Table S1147. Gene #124: 'RGL2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
RGL2 MUTATED	1	1	2
RGL2 WILD-TYPE	183	161	157

'RGL2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.582 (Fisher's exact test), Q value = 1

Table S1148. Gene #124: 'RGL2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
RGL2 MUTATED	0	1	3	0
RGL2 WILD-TYPE	90	137	185	89

'DSG3 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.145 (Fisher's exact test), Q value = 0.8

Table S1149. Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
DSG3 MUTATED	2	3	1	0
DSG3 WILD-TYPE	67	40	73	54

'DSG3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.641 (Fisher's exact test), Q value = 1

Table S1150. Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
DSG3 MUTATED	2	2	0	2
DSG3 WILD-TYPE	61	48	48	77

'DSG3 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.656 (Fisher's exact test), Q value = 1

Table S1151. Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
DSG3 MUTATED	1	3	1	3
DSG3 WILD-TYPE	76	90	44	57

'DSG3 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1152. Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
DSG3 MUTATED	4	2	2
DSG3 WILD-TYPE	134	59	74

'DSG3 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00096 (Fisher's exact test), Q value = 0.022

Table S1153. Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
DSG3 MUTATED	10	1	0
DSG3 WILD-TYPE	285	480	7

Figure S218. Get High-res Image Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'DSG3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0226 (Fisher's exact test), Q value = 0.26

Table S1154. Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
DSG3 MUTATED	5	1	0	0
DSG3 WILD-TYPE	155	231	64	166

Figure S219. Get High-res Image Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'DSG3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0423 (Fisher's exact test), Q value = 0.39

Table S1155. Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
DSG3 MUTATED	5	1	0
DSG3 WILD-TYPE	222	234	192

Figure S220. Get High-res Image Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'DSG3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00915 (Fisher's exact test), Q value = 0.14

Table S1156. Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
DSG3 MUTATED	5	1	0
DSG3 WILD-TYPE	191	189	268

Figure S221. Get High-res Image Gene #125: 'DSG3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'MYO5A MUTATION STATUS' versus 'CN_CNMF'

P value = 0.399 (Fisher's exact test), Q value = 1

Table S1157. Gene #126: 'MYO5A MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
MYO5A MUTATED	3	2	0
MYO5A WILD-TYPE	292	479	7

'MYO5A MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0373 (Fisher's exact test), Q value = 0.36

Table S1158. Gene #126: 'MYO5A MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
MYO5A MUTATED	4	0	0	1
MYO5A WILD-TYPE	156	232	64	165

Figure S222. Get High-res Image Gene #126: 'MYO5A MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'MYO5A MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.158 (Fisher's exact test), Q value = 0.84

Table S1159. Gene #126: 'MYO5A MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
MYO5A MUTATED	3	0	1
MYO5A WILD-TYPE	224	235	191

'MYO5A MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.823 (Fisher's exact test), Q value = 1

Table S1160. Gene #126: 'MYO5A MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
MYO5A MUTATED	2	1	1
MYO5A WILD-TYPE	194	189	267

'MYO5A MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.765 (Fisher's exact test), Q value = 1

Table S1161. Gene #126: 'MYO5A MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
MYO5A MUTATED	2	1	1	0
MYO5A WILD-TYPE	134	106	182	83

'MYO5A MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.344 (Fisher's exact test), Q value = 1

Table S1162. Gene #126: 'MYO5A MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
MYO5A MUTATED	1	1	2
MYO5A WILD-TYPE	221	183	101

'MYO5A MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.472 (Fisher's exact test), Q value = 1

Table S1163. Gene #126: 'MYO5A MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
MYO5A MUTATED	2	0	2
MYO5A WILD-TYPE	182	162	157

'MYO5A MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.527 (Fisher's exact test), Q value = 1

Table S1164. Gene #126: 'MYO5A MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
MYO5A MUTATED	1	0	2	1
MYO5A WILD-TYPE	89	138	186	88

'TMPRSS6 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.666 (Fisher's exact test), Q value = 1

Table S1165. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
TMPRSS6 MUTATED	2	0	3	1
TMPRSS6 WILD-TYPE	67	43	71	53

'TMPRSS6 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.703 (Fisher's exact test), Q value = 1

Table S1166. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
TMPRSS6 MUTATED	3	1	1	1
TMPRSS6 WILD-TYPE	60	49	47	78

'TMPRSS6 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.662 (Fisher's exact test), Q value = 1

Table S1167. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
TMPRSS6 MUTATED	3	1	1	1
TMPRSS6 WILD-TYPE	74	92	44	59

'TMPRSS6 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.265 (Fisher's exact test), Q value = 1

Table S1168. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
TMPRSS6 MUTATED	2	3	1
TMPRSS6 WILD-TYPE	136	58	75

'TMPRSS6 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0502 (Fisher's exact test), Q value = 0.43

Table S1169. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TMPRSS6 MUTATED	7	2	0
TMPRSS6 WILD-TYPE	288	479	7

'TMPRSS6 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0228 (Fisher's exact test), Q value = 0.26

Table S1170. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TMPRSS6 MUTATED	5	1	0	0
TMPRSS6 WILD-TYPE	155	231	64	166

Figure S223. Get High-res Image Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'TMPRSS6 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.00181 (Fisher's exact test), Q value = 0.037

Table S1171. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TMPRSS6 MUTATED	8	1	0
TMPRSS6 WILD-TYPE	219	234	192

Figure S224. Get High-res Image Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'TMPRSS6 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00707 (Fisher's exact test), Q value = 0.11

Table S1172. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TMPRSS6 MUTATED	6	3	0
TMPRSS6 WILD-TYPE	190	187	268

Figure S225. Get High-res Image Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'TMPRSS6 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.189 (Fisher's exact test), Q value = 0.9

Table S1173. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TMPRSS6 MUTATED	1	2	0	0
TMPRSS6 WILD-TYPE	135	105	183	83

'TMPRSS6 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.154 (Fisher's exact test), Q value = 0.83

Table S1174. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TMPRSS6 MUTATED	1	0	2
TMPRSS6 WILD-TYPE	221	184	101

'TMPRSS6 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.649 (Fisher's exact test), Q value = 1

Table S1175. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TMPRSS6 MUTATED	2	0	1
TMPRSS6 WILD-TYPE	182	162	158

'TMPRSS6 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.437 (Fisher's exact test), Q value = 1

Table S1176. Gene #127: 'TMPRSS6 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TMPRSS6 MUTATED	1	0	1	1
TMPRSS6 WILD-TYPE	89	138	187	88

'DYNC1I1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.138 (Fisher's exact test), Q value = 0.77

Table S1177. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
DYNC1I1 MUTATED	0	0	2	3
DYNC1I1 WILD-TYPE	69	43	72	51

'DYNC1I1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.235 (Fisher's exact test), Q value = 0.95

Table S1178. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
DYNC1I1 MUTATED	0	2	0	3
DYNC1I1 WILD-TYPE	63	48	48	76

'DYNC1I1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.738 (Fisher's exact test), Q value = 1

Table S1179. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
DYNC1I1 MUTATED	1	3	2	1
DYNC1I1 WILD-TYPE	76	90	43	59

'DYNC1I1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.205 (Fisher's exact test), Q value = 0.9

Table S1180. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
DYNC1I1 MUTATED	6	0	1
DYNC1I1 WILD-TYPE	132	61	75

'DYNC1I1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.259 (Fisher's exact test), Q value = 1

Table S1181. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
DYNC1I1 MUTATED	6	4	0
DYNC1I1 WILD-TYPE	289	477	7

'DYNC1I1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0722 (Fisher's exact test), Q value = 0.52

Table S1182. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
DYNC1I1 MUTATED	4	1	0	0
DYNC1I1 WILD-TYPE	156	231	64	166

'DYNC1I1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.537 (Fisher's exact test), Q value = 1

Table S1183. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
DYNC1I1 MUTATED	3	1	1
DYNC1I1 WILD-TYPE	224	234	191

'DYNC1I1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.618 (Fisher's exact test), Q value = 1

Table S1184. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
DYNC1I1 MUTATED	2	2	1
DYNC1I1 WILD-TYPE	194	188	267

'DYNC1I1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1185. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
DYNC1I1 MUTATED	1	1	1	0
DYNC1I1 WILD-TYPE	135	106	182	83

'DYNC1I1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.796 (Fisher's exact test), Q value = 1

Table S1186. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
DYNC1I1 MUTATED	1	1	1
DYNC1I1 WILD-TYPE	221	183	102

'DYNC1I1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.412 (Fisher's exact test), Q value = 1

Table S1187. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
DYNC1I1 MUTATED	1	0	2
DYNC1I1 WILD-TYPE	183	162	157

'DYNC1I1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.589 (Fisher's exact test), Q value = 1

Table S1188. Gene #128: 'DYNC1I1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
DYNC1I1 MUTATED	1	0	2	0
DYNC1I1 WILD-TYPE	89	138	186	89

'PASD1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1189. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
PASD1 MUTATED	1	0	1	1
PASD1 WILD-TYPE	68	43	73	53

'PASD1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.702 (Fisher's exact test), Q value = 1

Table S1190. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
PASD1 MUTATED	0	1	1	1
PASD1 WILD-TYPE	63	49	47	78

'PASD1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.52 (Fisher's exact test), Q value = 1

Table S1191. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PASD1 MUTATED	3	1	0	1
PASD1 WILD-TYPE	74	92	45	59

'PASD1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.0483 (Fisher's exact test), Q value = 0.41

Table S1192. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PASD1 MUTATED	1	0	4
PASD1 WILD-TYPE	137	61	72

Figure S226. Get High-res Image Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

'PASD1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.367 (Fisher's exact test), Q value = 1

Table S1193. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PASD1 MUTATED	5	4	0
PASD1 WILD-TYPE	290	477	7

'PASD1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.674 (Fisher's exact test), Q value = 1

Table S1194. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PASD1 MUTATED	3	2	0	2
PASD1 WILD-TYPE	157	230	64	164

'PASD1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.108 (Fisher's exact test), Q value = 0.67

Table S1195. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PASD1 MUTATED	0	1	3
PASD1 WILD-TYPE	227	234	189

'PASD1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.312 (Fisher's exact test), Q value = 1

Table S1196. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PASD1 MUTATED	0	1	3
PASD1 WILD-TYPE	196	189	265

'PASD1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.911 (Fisher's exact test), Q value = 1

Table S1197. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PASD1 MUTATED	1	1	1	1
PASD1 WILD-TYPE	135	106	182	82

'PASD1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.42 (Fisher's exact test), Q value = 1

Table S1198. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PASD1 MUTATED	1	3	0
PASD1 WILD-TYPE	221	181	103

'PASD1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0778 (Fisher's exact test), Q value = 0.54

Table S1199. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PASD1 MUTATED	0	1	3
PASD1 WILD-TYPE	184	161	156

'PASD1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.762 (Fisher's exact test), Q value = 1

Table S1200. Gene #129: 'PASD1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PASD1 MUTATED	0	2	2	0
PASD1 WILD-TYPE	90	136	186	89

'RPL7 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.575 (Fisher's exact test), Q value = 1

Table S1201. Gene #130: 'RPL7 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
RPL7 MUTATED	2	1	0
RPL7 WILD-TYPE	293	480	7

'RPL7 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0691 (Fisher's exact test), Q value = 0.5

Table S1202. Gene #130: 'RPL7 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
RPL7 MUTATED	3	0	0
RPL7 WILD-TYPE	224	235	192

'RPL7 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.274 (Fisher's exact test), Q value = 1

Table S1203. Gene #130: 'RPL7 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
RPL7 MUTATED	2	1	0
RPL7 WILD-TYPE	194	189	268

'CES3 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1204. Gene #131: 'CES3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CES3 MUTATED	1	3	0
CES3 WILD-TYPE	294	478	7

'CES3 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1205. Gene #131: 'CES3 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CES3 MUTATED	1	2	0	1
CES3 WILD-TYPE	159	230	64	165

'CES3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.296 (Fisher's exact test), Q value = 1

Table S1206. Gene #131: 'CES3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CES3 MUTATED	0	1	2
CES3 WILD-TYPE	227	234	190

'CES3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.634 (Fisher's exact test), Q value = 1

Table S1207. Gene #131: 'CES3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CES3 MUTATED	0	1	2
CES3 WILD-TYPE	196	189	266

'CES3 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.446 (Fisher's exact test), Q value = 1

Table S1208. Gene #131: 'CES3 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CES3 MUTATED	0	0	2	1
CES3 WILD-TYPE	136	107	181	82

'CES3 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1209. Gene #131: 'CES3 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CES3 MUTATED	2	1	0
CES3 WILD-TYPE	220	183	103

'CES3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.207 (Fisher's exact test), Q value = 0.9

Table S1210. Gene #131: 'CES3 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CES3 MUTATED	0	1	2
CES3 WILD-TYPE	184	161	157

'CES3 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1211. Gene #131: 'CES3 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CES3 MUTATED	0	1	2	0
CES3 WILD-TYPE	90	137	186	89

'CLEC12A MUTATION STATUS' versus 'CN_CNMF'

P value = 0.399 (Fisher's exact test), Q value = 1

Table S1212. Gene #132: 'CLEC12A MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CLEC12A MUTATED	3	2	0
CLEC12A WILD-TYPE	292	479	7

'CLEC12A MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.224 (Fisher's exact test), Q value = 0.92

Table S1213. Gene #132: 'CLEC12A MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CLEC12A MUTATED	3	1	0	0
CLEC12A WILD-TYPE	157	231	64	166

'CLEC12A MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.54 (Fisher's exact test), Q value = 1

Table S1214. Gene #132: 'CLEC12A MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CLEC12A MUTATED	3	1	1
CLEC12A WILD-TYPE	224	234	191

'CLEC12A MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.619 (Fisher's exact test), Q value = 1

Table S1215. Gene #132: 'CLEC12A MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CLEC12A MUTATED	2	2	1
CLEC12A WILD-TYPE	194	188	267

'CLEC12A MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.081 (Fisher's exact test), Q value = 0.56

Table S1216. Gene #132: 'CLEC12A MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CLEC12A MUTATED	0	3	1	0
CLEC12A WILD-TYPE	136	104	182	83

'CLEC12A MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.342 (Fisher's exact test), Q value = 1

Table S1217. Gene #132: 'CLEC12A MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CLEC12A MUTATED	1	1	2
CLEC12A WILD-TYPE	221	183	101

'CLEC12A MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.693 (Fisher's exact test), Q value = 1

Table S1218. Gene #132: 'CLEC12A MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CLEC12A MUTATED	1	1	2
CLEC12A WILD-TYPE	183	161	157

'CLEC12A MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.918 (Fisher's exact test), Q value = 1

Table S1219. Gene #132: 'CLEC12A MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CLEC12A MUTATED	0	1	2	1
CLEC12A WILD-TYPE	90	137	186	88

'CACNA1S MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.525 (Fisher's exact test), Q value = 1

Table S1220. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
CACNA1S MUTATED	2	0	2	3
CACNA1S WILD-TYPE	67	43	72	51

'CACNA1S MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.769 (Fisher's exact test), Q value = 1

Table S1221. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
CACNA1S MUTATED	1	2	2	2
CACNA1S WILD-TYPE	62	48	46	77

'CACNA1S MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.597 (Fisher's exact test), Q value = 1

Table S1222. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
CACNA1S MUTATED	2	3	1	0
CACNA1S WILD-TYPE	75	90	44	60

'CACNA1S MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1223. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
CACNA1S MUTATED	3	1	2
CACNA1S WILD-TYPE	135	60	74

'CACNA1S MUTATION STATUS' versus 'CN_CNMF'

P value = 0.147 (Fisher's exact test), Q value = 0.81

Table S1224. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CACNA1S MUTATED	4	8	1
CACNA1S WILD-TYPE	291	473	6

'CACNA1S MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.289 (Fisher's exact test), Q value = 1

Table S1225. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CACNA1S MUTATED	5	3	1	1
CACNA1S WILD-TYPE	155	229	63	165

'CACNA1S MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.112 (Fisher's exact test), Q value = 0.68

Table S1226. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CACNA1S MUTATED	8	2	3
CACNA1S WILD-TYPE	219	233	189

'CACNA1S MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.407 (Fisher's exact test), Q value = 1

Table S1227. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CACNA1S MUTATED	6	2	5
CACNA1S WILD-TYPE	190	188	263

'CACNA1S MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.415 (Fisher's exact test), Q value = 1

Table S1228. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CACNA1S MUTATED	1	3	3	0
CACNA1S WILD-TYPE	135	104	180	83

'CACNA1S MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.691 (Fisher's exact test), Q value = 1

Table S1229. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CACNA1S MUTATED	2	3	2
CACNA1S WILD-TYPE	220	181	101

'CACNA1S MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.355 (Fisher's exact test), Q value = 1

Table S1230. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CACNA1S MUTATED	2	1	4
CACNA1S WILD-TYPE	182	161	155

'CACNA1S MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.266 (Fisher's exact test), Q value = 1

Table S1231. Gene #133: 'CACNA1S MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CACNA1S MUTATED	2	0	4	1
CACNA1S WILD-TYPE	88	138	184	88

'SON MUTATION STATUS' versus 'CN_CNMF'

P value = 0.537 (Fisher's exact test), Q value = 1

Table S1232. Gene #134: 'SON MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SON MUTATED	2	7	0
SON WILD-TYPE	293	474	7

'SON MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.511 (Fisher's exact test), Q value = 1

Table S1233. Gene #134: 'SON MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SON MUTATED	4	2	0	2
SON WILD-TYPE	156	230	64	164

'SON MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.839 (Fisher's exact test), Q value = 1

Table S1234. Gene #134: 'SON MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SON MUTATED	4	3	2
SON WILD-TYPE	223	232	190

'SON MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.841 (Fisher's exact test), Q value = 1

Table S1235. Gene #134: 'SON MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SON MUTATED	3	3	3
SON WILD-TYPE	193	187	265

'SON MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.827 (Fisher's exact test), Q value = 1

Table S1236. Gene #134: 'SON MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SON MUTATED	2	2	2	2
SON WILD-TYPE	134	105	181	81

'SON MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.517 (Fisher's exact test), Q value = 1

Table S1237. Gene #134: 'SON MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SON MUTATED	3	2	3
SON WILD-TYPE	219	182	100

'SON MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.641 (Fisher's exact test), Q value = 1

Table S1238. Gene #134: 'SON MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SON MUTATED	3	1	3
SON WILD-TYPE	181	161	156

'SON MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.156 (Fisher's exact test), Q value = 0.84

Table S1239. Gene #134: 'SON MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SON MUTATED	1	0	3	3
SON WILD-TYPE	89	138	185	86

'SLC35A2 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1240. Gene #135: 'SLC35A2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SLC35A2 MUTATED	1	2	0
SLC35A2 WILD-TYPE	294	479	7

'SLC35A2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1241. Gene #135: 'SLC35A2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SLC35A2 MUTATED	1	1	1
SLC35A2 WILD-TYPE	226	234	191

'SLC35A2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1242. Gene #135: 'SLC35A2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SLC35A2 MUTATED	1	1	1
SLC35A2 WILD-TYPE	195	189	267

'OR2A12 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.397 (Fisher's exact test), Q value = 1

Table S1243. Gene #136: 'OR2A12 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
OR2A12 MUTATED	0	2	1	0
OR2A12 WILD-TYPE	77	91	44	60

'OR2A12 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.79 (Fisher's exact test), Q value = 1

Table S1244. Gene #136: 'OR2A12 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
OR2A12 MUTATED	1	1	1
OR2A12 WILD-TYPE	137	60	75

'OR2A12 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1245. Gene #136: 'OR2A12 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
OR2A12 MUTATED	3	4	0
OR2A12 WILD-TYPE	292	477	7

'OR2A12 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.922 (Fisher's exact test), Q value = 1

Table S1246. Gene #136: 'OR2A12 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
OR2A12 MUTATED	2	2	0	1
OR2A12 WILD-TYPE	158	230	64	165

'OR2A12 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1247. Gene #136: 'OR2A12 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
OR2A12 MUTATED	1	2	1
OR2A12 WILD-TYPE	226	233	191

'OR2A12 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.695 (Fisher's exact test), Q value = 1

Table S1248. Gene #136: 'OR2A12 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
OR2A12 MUTATED	1	2	1
OR2A12 WILD-TYPE	195	188	267

'OR2A12 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.327 (Fisher's exact test), Q value = 1

Table S1249. Gene #136: 'OR2A12 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
OR2A12 MUTATED	0	2	1	0
OR2A12 WILD-TYPE	136	105	182	83

'OR2A12 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.791 (Fisher's exact test), Q value = 1

Table S1250. Gene #136: 'OR2A12 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
OR2A12 MUTATED	1	1	1
OR2A12 WILD-TYPE	221	183	102

'OR2A12 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1251. Gene #136: 'OR2A12 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
OR2A12 MUTATED	1	1	1
OR2A12 WILD-TYPE	183	161	158

'OR2A12 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.667 (Fisher's exact test), Q value = 1

Table S1252. Gene #136: 'OR2A12 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
OR2A12 MUTATED	0	2	1	0
OR2A12 WILD-TYPE	90	136	187	89

'PLCG2 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.53 (Fisher's exact test), Q value = 1

Table S1253. Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PLCG2 MUTATED	0	1	1	1
PLCG2 WILD-TYPE	77	92	44	59

'PLCG2 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1254. Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PLCG2 MUTATED	2	0	1
PLCG2 WILD-TYPE	136	61	75

'PLCG2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.41 (Fisher's exact test), Q value = 1

Table S1255. Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PLCG2 MUTATED	6	5	0
PLCG2 WILD-TYPE	289	476	7

'PLCG2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0357 (Fisher's exact test), Q value = 0.35

Table S1256. Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PLCG2 MUTATED	5	2	2	0
PLCG2 WILD-TYPE	155	230	62	166

Figure S227. Get High-res Image Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'PLCG2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.403 (Fisher's exact test), Q value = 1

Table S1257. Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PLCG2 MUTATED	4	1	3
PLCG2 WILD-TYPE	223	234	189

'PLCG2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.736 (Fisher's exact test), Q value = 1

Table S1258. Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PLCG2 MUTATED	3	3	2
PLCG2 WILD-TYPE	193	187	266

'PLCG2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.254 (Fisher's exact test), Q value = 0.99

Table S1259. Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PLCG2 MUTATED	2	4	2	0
PLCG2 WILD-TYPE	134	103	181	83

'PLCG2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0225 (Fisher's exact test), Q value = 0.26

Table S1260. Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PLCG2 MUTATED	2	1	5
PLCG2 WILD-TYPE	220	183	98

Figure S228. Get High-res Image Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'PLCG2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.501 (Fisher's exact test), Q value = 1

Table S1261. Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PLCG2 MUTATED	4	1	3
PLCG2 WILD-TYPE	180	161	156

'PLCG2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0949 (Fisher's exact test), Q value = 0.61

Table S1262. Gene #137: 'PLCG2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PLCG2 MUTATED	0	1	3	4
PLCG2 WILD-TYPE	90	137	185	85

'HTT MUTATION STATUS' versus 'CN_CNMF'

P value = 0.201 (Fisher's exact test), Q value = 0.9

Table S1263. Gene #138: 'HTT MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
HTT MUTATED	0	5	0
HTT WILD-TYPE	295	476	7

'HTT MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0482 (Fisher's exact test), Q value = 0.41

Table S1264. Gene #138: 'HTT MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
HTT MUTATED	1	0	0	4
HTT WILD-TYPE	159	232	64	162

Figure S229. Get High-res Image Gene #138: 'HTT MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'HTT MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.17 (Fisher's exact test), Q value = 0.86

Table S1265. Gene #138: 'HTT MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
HTT MUTATED	2	0	3
HTT WILD-TYPE	225	235	189

'HTT MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.341 (Fisher's exact test), Q value = 1

Table S1266. Gene #138: 'HTT MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
HTT MUTATED	0	2	3
HTT WILD-TYPE	196	188	265

'HTT MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.263 (Fisher's exact test), Q value = 1

Table S1267. Gene #138: 'HTT MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
HTT MUTATED	0	2	3	0
HTT WILD-TYPE	136	105	180	83

'HTT MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0237 (Fisher's exact test), Q value = 0.26

Table S1268. Gene #138: 'HTT MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
HTT MUTATED	0	2	3
HTT WILD-TYPE	222	182	100

Figure S230. Get High-res Image Gene #138: 'HTT MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'HTT MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.455 (Fisher's exact test), Q value = 1

Table S1269. Gene #138: 'HTT MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
HTT MUTATED	1	1	3
HTT WILD-TYPE	183	161	156

'HTT MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.71 (Fisher's exact test), Q value = 1

Table S1270. Gene #138: 'HTT MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
HTT MUTATED	0	1	3	1
HTT WILD-TYPE	90	137	185	88

'MAP3K1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1271. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
MAP3K1 MUTATED	1	1	2	1
MAP3K1 WILD-TYPE	68	42	72	53

'MAP3K1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.728 (Fisher's exact test), Q value = 1

Table S1272. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
MAP3K1 MUTATED	1	1	2	1
MAP3K1 WILD-TYPE	62	49	46	78

'MAP3K1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.807 (Fisher's exact test), Q value = 1

Table S1273. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
MAP3K1 MUTATED	2	2	0	2
MAP3K1 WILD-TYPE	75	91	45	58

'MAP3K1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.646 (Fisher's exact test), Q value = 1

Table S1274. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
MAP3K1 MUTATED	2	2	2
MAP3K1 WILD-TYPE	136	59	74

'MAP3K1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.162 (Fisher's exact test), Q value = 0.84

Table S1275. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
MAP3K1 MUTATED	6	3	0
MAP3K1 WILD-TYPE	289	478	7

'MAP3K1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.546 (Fisher's exact test), Q value = 1

Table S1276. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
MAP3K1 MUTATED	2	2	0	0
MAP3K1 WILD-TYPE	158	230	64	166

'MAP3K1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.163 (Fisher's exact test), Q value = 0.84

Table S1277. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
MAP3K1 MUTATED	5	1	1
MAP3K1 WILD-TYPE	222	234	191

'MAP3K1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.271 (Fisher's exact test), Q value = 1

Table S1278. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
MAP3K1 MUTATED	4	2	1
MAP3K1 WILD-TYPE	192	188	267

'MAP3K1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.327 (Fisher's exact test), Q value = 1

Table S1279. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
MAP3K1 MUTATED	0	2	1	0
MAP3K1 WILD-TYPE	136	105	182	83

'MAP3K1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0526 (Fisher's exact test), Q value = 0.43

Table S1280. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
MAP3K1 MUTATED	0	1	2
MAP3K1 WILD-TYPE	222	183	101

'MAP3K1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.206 (Fisher's exact test), Q value = 0.9

Table S1281. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
MAP3K1 MUTATED	0	1	2
MAP3K1 WILD-TYPE	184	161	157

'MAP3K1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1282. Gene #139: 'MAP3K1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
MAP3K1 MUTATED	0	1	2	0
MAP3K1 WILD-TYPE	90	137	186	89

'BBS9 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.402 (Fisher's exact test), Q value = 1

Table S1283. Gene #140: 'BBS9 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
BBS9 MUTATED	3	2	0
BBS9 WILD-TYPE	292	479	7

'BBS9 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.00788 (Fisher's exact test), Q value = 0.12

Table S1284. Gene #140: 'BBS9 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
BBS9 MUTATED	2	0	2	0
BBS9 WILD-TYPE	158	232	62	166

Figure S231. Get High-res Image Gene #140: 'BBS9 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'BBS9 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.159 (Fisher's exact test), Q value = 0.84

Table S1285. Gene #140: 'BBS9 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
BBS9 MUTATED	3	0	1
BBS9 WILD-TYPE	224	235	191

'BBS9 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.823 (Fisher's exact test), Q value = 1

Table S1286. Gene #140: 'BBS9 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
BBS9 MUTATED	2	1	1
BBS9 WILD-TYPE	194	189	267

'BBS9 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.33 (Fisher's exact test), Q value = 1

Table S1287. Gene #140: 'BBS9 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
BBS9 MUTATED	0	2	1	0
BBS9 WILD-TYPE	136	105	182	83

'BBS9 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0549 (Fisher's exact test), Q value = 0.43

Table S1288. Gene #140: 'BBS9 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
BBS9 MUTATED	0	1	2
BBS9 WILD-TYPE	222	183	101

'BBS9 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.413 (Fisher's exact test), Q value = 1

Table S1289. Gene #140: 'BBS9 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
BBS9 MUTATED	1	0	2
BBS9 WILD-TYPE	183	162	157

'BBS9 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.509 (Fisher's exact test), Q value = 1

Table S1290. Gene #140: 'BBS9 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
BBS9 MUTATED	0	0	2	1
BBS9 WILD-TYPE	90	138	186	88

'CSNK2B MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1291. Gene #141: 'CSNK2B MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CSNK2B MUTATED	1	2	0
CSNK2B WILD-TYPE	294	479	7

'CSNK2B MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.298 (Fisher's exact test), Q value = 1

Table S1292. Gene #141: 'CSNK2B MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CSNK2B MUTATED	2	0	0	1
CSNK2B WILD-TYPE	158	232	64	165

'CCDC110 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.732 (Fisher's exact test), Q value = 1

Table S1293. Gene #142: 'CCDC110 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CCDC110 MUTATED	2	5	0
CCDC110 WILD-TYPE	293	476	7

'CCDC110 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.505 (Fisher's exact test), Q value = 1

Table S1294. Gene #142: 'CCDC110 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CCDC110 MUTATED	2	3	0	0
CCDC110 WILD-TYPE	158	229	64	166

'CCDC110 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.558 (Fisher's exact test), Q value = 1

Table S1295. Gene #142: 'CCDC110 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CCDC110 MUTATED	2	2	0
CCDC110 WILD-TYPE	225	233	192

'CCDC110 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.695 (Fisher's exact test), Q value = 1

Table S1296. Gene #142: 'CCDC110 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CCDC110 MUTATED	1	2	1
CCDC110 WILD-TYPE	195	188	267

'CCDC110 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.0948 (Fisher's exact test), Q value = 0.61

Table S1297. Gene #142: 'CCDC110 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CCDC110 MUTATED	3	1	0	0
CCDC110 WILD-TYPE	133	106	183	83

'CCDC110 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.197 (Fisher's exact test), Q value = 0.9

Table S1298. Gene #142: 'CCDC110 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CCDC110 MUTATED	2	0	2
CCDC110 WILD-TYPE	220	184	101

'CCDC110 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.397 (Fisher's exact test), Q value = 1

Table S1299. Gene #142: 'CCDC110 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CCDC110 MUTATED	3	1	0
CCDC110 WILD-TYPE	181	161	159

'CCDC110 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.124 (Fisher's exact test), Q value = 0.72

Table S1300. Gene #142: 'CCDC110 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CCDC110 MUTATED	1	1	0	2
CCDC110 WILD-TYPE	89	137	188	87

'ATF7IP2 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.911 (Fisher's exact test), Q value = 1

Table S1301. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
ATF7IP2 MUTATED	1	0	2	1
ATF7IP2 WILD-TYPE	68	43	72	53

'ATF7IP2 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1302. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
ATF7IP2 MUTATED	1	1	1	1
ATF7IP2 WILD-TYPE	62	49	47	78

'ATF7IP2 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.288 (Fisher's exact test), Q value = 1

Table S1303. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
ATF7IP2 MUTATED	1	1	0	3
ATF7IP2 WILD-TYPE	76	92	45	57

'ATF7IP2 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.105 (Fisher's exact test), Q value = 0.66

Table S1304. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
ATF7IP2 MUTATED	1	3	1
ATF7IP2 WILD-TYPE	137	58	75

'ATF7IP2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00314 (Fisher's exact test), Q value = 0.058

Table S1305. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ATF7IP2 MUTATED	6	1	1
ATF7IP2 WILD-TYPE	289	480	6

Figure S232. Get High-res Image Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'ATF7IP2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.311 (Fisher's exact test), Q value = 1

Table S1306. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ATF7IP2 MUTATED	2	1	1	0
ATF7IP2 WILD-TYPE	158	231	63	166

'ATF7IP2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0215 (Fisher's exact test), Q value = 0.25

Table S1307. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ATF7IP2 MUTATED	4	0	0
ATF7IP2 WILD-TYPE	223	235	192

Figure S233. Get High-res Image Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'ATF7IP2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.102 (Fisher's exact test), Q value = 0.65

Table S1308. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ATF7IP2 MUTATED	3	1	0
ATF7IP2 WILD-TYPE	193	189	268

'ATF7IP2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1309. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ATF7IP2 MUTATED	1	1	1	0
ATF7IP2 WILD-TYPE	135	106	182	83

'ATF7IP2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.00755 (Fisher's exact test), Q value = 0.12

Table S1310. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ATF7IP2 MUTATED	0	0	3
ATF7IP2 WILD-TYPE	222	184	100

Figure S234. Get High-res Image Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'ATF7IP2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.647 (Fisher's exact test), Q value = 1

Table S1311. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ATF7IP2 MUTATED	2	0	1
ATF7IP2 WILD-TYPE	182	162	158

'ATF7IP2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0889 (Fisher's exact test), Q value = 0.59

Table S1312. Gene #143: 'ATF7IP2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ATF7IP2 MUTATED	0	1	0	2
ATF7IP2 WILD-TYPE	90	137	188	87

'QKI MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.265 (Fisher's exact test), Q value = 1

Table S1313. Gene #144: 'QKI MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
QKI MUTATED	3	1	0	1
QKI WILD-TYPE	66	42	74	53

'QKI MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.0595 (Fisher's exact test), Q value = 0.46

Table S1314. Gene #144: 'QKI MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
QKI MUTATED	4	0	0	1
QKI WILD-TYPE	59	50	48	78

'QKI MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.765 (Fisher's exact test), Q value = 1

Table S1315. Gene #144: 'QKI MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
QKI MUTATED	1	2	0	2
QKI WILD-TYPE	76	91	45	58

'QKI MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1316. Gene #144: 'QKI MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
QKI MUTATED	3	1	1
QKI WILD-TYPE	135	60	75

'QKI MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0079 (Fisher's exact test), Q value = 0.12

Table S1317. Gene #144: 'QKI MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
QKI MUTATED	4	1	1
QKI WILD-TYPE	291	480	6

Figure S235. Get High-res Image Gene #144: 'QKI MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'QKI MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.313 (Fisher's exact test), Q value = 1

Table S1318. Gene #144: 'QKI MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
QKI MUTATED	2	1	1	0
QKI WILD-TYPE	158	231	63	166

'QKI MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.64 (Fisher's exact test), Q value = 1

Table S1319. Gene #144: 'QKI MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
QKI MUTATED	2	1	0
QKI WILD-TYPE	225	234	192

'QKI MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.272 (Fisher's exact test), Q value = 1

Table S1320. Gene #144: 'QKI MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
QKI MUTATED	2	1	0
QKI WILD-TYPE	194	189	268

'CD72 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0271 (Fisher's exact test), Q value = 0.29

Table S1321. Gene #145: 'CD72 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CD72 MUTATED	1	1	1
CD72 WILD-TYPE	294	480	6

Figure S236. Get High-res Image Gene #145: 'CD72 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'CD72 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.732 (Fisher's exact test), Q value = 1

Table S1322. Gene #145: 'CD72 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CD72 MUTATED	1	2	0	0
CD72 WILD-TYPE	159	230	64	166

'CD72 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.646 (Fisher's exact test), Q value = 1

Table S1323. Gene #145: 'CD72 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CD72 MUTATED	2	1	0
CD72 WILD-TYPE	225	234	192

'CD72 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.195 (Fisher's exact test), Q value = 0.9

Table S1324. Gene #145: 'CD72 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CD72 MUTATED	1	2	0
CD72 WILD-TYPE	195	188	268

'CD72 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.191 (Fisher's exact test), Q value = 0.9

Table S1325. Gene #145: 'CD72 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CD72 MUTATED	1	2	0	0
CD72 WILD-TYPE	135	105	183	83

'CD72 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.154 (Fisher's exact test), Q value = 0.83

Table S1326. Gene #145: 'CD72 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CD72 MUTATED	1	0	2
CD72 WILD-TYPE	221	184	101

'CD72 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.112 (Fisher's exact test), Q value = 0.68

Table S1327. Gene #145: 'CD72 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CD72 MUTATED	3	0	0
CD72 WILD-TYPE	181	162	159

'CD72 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0279 (Fisher's exact test), Q value = 0.29

Table S1328. Gene #145: 'CD72 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CD72 MUTATED	1	0	0	2
CD72 WILD-TYPE	89	138	188	87

Figure S237. Get High-res Image Gene #145: 'CD72 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'SPINT1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.549 (Fisher's exact test), Q value = 1

Table S1329. Gene #146: 'SPINT1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
SPINT1 MUTATED	1	1	0	1
SPINT1 WILD-TYPE	68	42	74	53

'SPINT1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.304 (Fisher's exact test), Q value = 1

Table S1330. Gene #146: 'SPINT1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
SPINT1 MUTATED	0	2	0	1
SPINT1 WILD-TYPE	63	48	48	78

'SPINT1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.118 (Fisher's exact test), Q value = 0.7

Table S1331. Gene #146: 'SPINT1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
SPINT1 MUTATED	0	2	2	0
SPINT1 WILD-TYPE	77	91	43	60

'SPINT1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.812 (Fisher's exact test), Q value = 1

Table S1332. Gene #146: 'SPINT1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
SPINT1 MUTATED	3	0	1
SPINT1 WILD-TYPE	135	61	75

'SPINT1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.696 (Fisher's exact test), Q value = 1

Table S1333. Gene #146: 'SPINT1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SPINT1 MUTATED	3	3	0
SPINT1 WILD-TYPE	292	478	7

'SPINT1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.392 (Fisher's exact test), Q value = 1

Table S1334. Gene #146: 'SPINT1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SPINT1 MUTATED	1	2	1	0
SPINT1 WILD-TYPE	159	230	63	166

'SPINT1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.202 (Fisher's exact test), Q value = 0.9

Table S1335. Gene #146: 'SPINT1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SPINT1 MUTATED	1	0	2
SPINT1 WILD-TYPE	226	235	190

'SPINT1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1336. Gene #146: 'SPINT1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SPINT1 MUTATED	1	1	1
SPINT1 WILD-TYPE	195	189	267

'MORN5 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.574 (Fisher's exact test), Q value = 1

Table S1337. Gene #147: 'MORN5 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
MORN5 MUTATED	2	1	0
MORN5 WILD-TYPE	293	480	7

'EGR1 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.7 (Fisher's exact test), Q value = 1

Table S1338. Gene #148: 'EGR1 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
EGR1 MUTATED	2	0	1	0
EGR1 WILD-TYPE	67	43	73	54

'EGR1 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.785 (Fisher's exact test), Q value = 1

Table S1339. Gene #148: 'EGR1 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
EGR1 MUTATED	1	0	0	2
EGR1 WILD-TYPE	62	50	48	77

'EGR1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.241 (Fisher's exact test), Q value = 0.96

Table S1340. Gene #148: 'EGR1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
EGR1 MUTATED	1	0	0	2
EGR1 WILD-TYPE	76	93	45	58

'EGR1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.194 (Fisher's exact test), Q value = 0.9

Table S1341. Gene #148: 'EGR1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
EGR1 MUTATED	1	2	0
EGR1 WILD-TYPE	137	59	76

'EGR1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1342. Gene #148: 'EGR1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
EGR1 MUTATED	2	3	0
EGR1 WILD-TYPE	293	478	7

'EGR1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.159 (Fisher's exact test), Q value = 0.84

Table S1343. Gene #148: 'EGR1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
EGR1 MUTATED	3	0	1
EGR1 WILD-TYPE	224	235	191

'EGR1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.823 (Fisher's exact test), Q value = 1

Table S1344. Gene #148: 'EGR1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
EGR1 MUTATED	2	1	1
EGR1 WILD-TYPE	194	189	267

'OR2A25 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.696 (Fisher's exact test), Q value = 1

Table S1345. Gene #149: 'OR2A25 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
OR2A25 MUTATED	3	3	0
OR2A25 WILD-TYPE	292	478	7

'OR2A25 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.925 (Fisher's exact test), Q value = 1

Table S1346. Gene #149: 'OR2A25 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
OR2A25 MUTATED	2	2	0	1
OR2A25 WILD-TYPE	158	230	64	165

'OR2A25 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.744 (Fisher's exact test), Q value = 1

Table S1347. Gene #149: 'OR2A25 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
OR2A25 MUTATED	2	1	2
OR2A25 WILD-TYPE	225	234	190

'OR2A25 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1348. Gene #149: 'OR2A25 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
OR2A25 MUTATED	2	1	2
OR2A25 WILD-TYPE	194	189	266

'OR2A25 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.442 (Fisher's exact test), Q value = 1

Table S1349. Gene #149: 'OR2A25 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
OR2A25 MUTATED	0	1	3	0
OR2A25 WILD-TYPE	136	106	180	83

'OR2A25 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.683 (Fisher's exact test), Q value = 1

Table S1350. Gene #149: 'OR2A25 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
OR2A25 MUTATED	1	2	1
OR2A25 WILD-TYPE	221	182	102

'OR2A25 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.476 (Fisher's exact test), Q value = 1

Table S1351. Gene #149: 'OR2A25 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
OR2A25 MUTATED	2	0	2
OR2A25 WILD-TYPE	182	162	157

'OR2A25 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.524 (Fisher's exact test), Q value = 1

Table S1352. Gene #149: 'OR2A25 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
OR2A25 MUTATED	1	0	2	1
OR2A25 WILD-TYPE	89	138	186	88

'PDGFRB MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.125 (Fisher's exact test), Q value = 0.72

Table S1353. Gene #150: 'PDGFRB MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PDGFRB MUTATED	0	1	2	0
PDGFRB WILD-TYPE	77	92	43	60

'PDGFRB MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.436 (Fisher's exact test), Q value = 1

Table S1354. Gene #150: 'PDGFRB MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PDGFRB MUTATED	3	0	0
PDGFRB WILD-TYPE	135	61	76

'PDGFRB MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0549 (Fisher's exact test), Q value = 0.43

Table S1355. Gene #150: 'PDGFRB MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PDGFRB MUTATED	4	0	0
PDGFRB WILD-TYPE	291	481	7

'PDGFRB MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.045 (Fisher's exact test), Q value = 0.4

Table S1356. Gene #150: 'PDGFRB MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PDGFRB MUTATED	3	0	0	0
PDGFRB WILD-TYPE	157	232	64	166

Figure S238. Get High-res Image Gene #150: 'PDGFRB MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'PDGFRB MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0664 (Fisher's exact test), Q value = 0.49

Table S1357. Gene #150: 'PDGFRB MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PDGFRB MUTATED	3	0	0
PDGFRB WILD-TYPE	224	235	192

'PDGFRB MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0513 (Fisher's exact test), Q value = 0.43

Table S1358. Gene #150: 'PDGFRB MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PDGFRB MUTATED	3	0	0
PDGFRB WILD-TYPE	193	190	268

'MTMR12 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.187 (Fisher's exact test), Q value = 0.9

Table S1359. Gene #151: 'MTMR12 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
MTMR12 MUTATED	3	1	0
MTMR12 WILD-TYPE	292	480	7

'MTMR12 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0456 (Fisher's exact test), Q value = 0.4

Table S1360. Gene #151: 'MTMR12 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
MTMR12 MUTATED	3	0	0	0
MTMR12 WILD-TYPE	157	232	64	166

Figure S239. Get High-res Image Gene #151: 'MTMR12 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'MTMR12 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0205 (Fisher's exact test), Q value = 0.24

Table S1361. Gene #151: 'MTMR12 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
MTMR12 MUTATED	4	0	0
MTMR12 WILD-TYPE	223	235	192

Figure S240. Get High-res Image Gene #151: 'MTMR12 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'MTMR12 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.103 (Fisher's exact test), Q value = 0.65

Table S1362. Gene #151: 'MTMR12 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
MTMR12 MUTATED	3	1	0
MTMR12 WILD-TYPE	193	189	268

'AMBRA1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1363. Gene #152: 'AMBRA1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
AMBRA1 MUTATED	2	4	0
AMBRA1 WILD-TYPE	293	477	7

'AMBRA1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.248 (Fisher's exact test), Q value = 0.98

Table S1364. Gene #152: 'AMBRA1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
AMBRA1 MUTATED	3	2	0	0
AMBRA1 WILD-TYPE	157	230	64	166

'AMBRA1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.333 (Fisher's exact test), Q value = 1

Table S1365. Gene #152: 'AMBRA1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
AMBRA1 MUTATED	3	2	0
AMBRA1 WILD-TYPE	224	233	192

'AMBRA1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0145 (Fisher's exact test), Q value = 0.19

Table S1366. Gene #152: 'AMBRA1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
AMBRA1 MUTATED	1	4	0
AMBRA1 WILD-TYPE	195	186	268

Figure S241. Get High-res Image Gene #152: 'AMBRA1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'AMBRA1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.00248 (Fisher's exact test), Q value = 0.048

Table S1367. Gene #152: 'AMBRA1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
AMBRA1 MUTATED	0	4	0	0
AMBRA1 WILD-TYPE	136	103	183	83

Figure S242. Get High-res Image Gene #152: 'AMBRA1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'AMBRA1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.00159 (Fisher's exact test), Q value = 0.034

Table S1368. Gene #152: 'AMBRA1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
AMBRA1 MUTATED	0	0	4
AMBRA1 WILD-TYPE	222	184	99

Figure S243. Get High-res Image Gene #152: 'AMBRA1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'AMBRA1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.272 (Fisher's exact test), Q value = 1

Table S1369. Gene #152: 'AMBRA1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
AMBRA1 MUTATED	3	0	1
AMBRA1 WILD-TYPE	181	162	158

'AMBRA1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.84 (Fisher's exact test), Q value = 1

Table S1370. Gene #152: 'AMBRA1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
AMBRA1 MUTATED	1	1	1	1
AMBRA1 WILD-TYPE	89	137	187	88

'BTNL2 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1371. Gene #153: 'BTNL2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
BTNL2 MUTATED	1	3	0
BTNL2 WILD-TYPE	294	478	7

'BTNL2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1372. Gene #153: 'BTNL2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
BTNL2 MUTATED	1	1	1
BTNL2 WILD-TYPE	226	234	191

'BTNL2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1373. Gene #153: 'BTNL2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
BTNL2 MUTATED	1	1	1
BTNL2 WILD-TYPE	195	189	267

'RPTN MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.783 (Fisher's exact test), Q value = 1

Table S1374. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
RPTN MUTATED	1	0	2	0
RPTN WILD-TYPE	68	43	72	54

'RPTN MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.891 (Fisher's exact test), Q value = 1

Table S1375. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
RPTN MUTATED	1	0	1	1
RPTN WILD-TYPE	62	50	47	78

'RPTN MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.916 (Fisher's exact test), Q value = 1

Table S1376. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
RPTN MUTATED	1	1	1	1
RPTN WILD-TYPE	76	92	44	59

'RPTN MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.812 (Fisher's exact test), Q value = 1

Table S1377. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
RPTN MUTATED	3	0	1
RPTN WILD-TYPE	135	61	75

'RPTN MUTATION STATUS' versus 'CN_CNMF'

P value = 0.471 (Fisher's exact test), Q value = 1

Table S1378. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
RPTN MUTATED	4	3	0
RPTN WILD-TYPE	291	478	7

'RPTN MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.249 (Fisher's exact test), Q value = 0.98

Table S1379. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
RPTN MUTATED	3	2	0	0
RPTN WILD-TYPE	157	230	64	166

'RPTN MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.54 (Fisher's exact test), Q value = 1

Table S1380. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
RPTN MUTATED	3	1	1
RPTN WILD-TYPE	224	234	191

'RPTN MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0894 (Fisher's exact test), Q value = 0.59

Table S1381. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
RPTN MUTATED	2	3	0
RPTN WILD-TYPE	194	187	268

'RPTN MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.763 (Fisher's exact test), Q value = 1

Table S1382. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
RPTN MUTATED	2	1	1	0
RPTN WILD-TYPE	134	106	182	83

'RPTN MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.343 (Fisher's exact test), Q value = 1

Table S1383. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
RPTN MUTATED	1	1	2
RPTN WILD-TYPE	221	183	101

'RPTN MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.272 (Fisher's exact test), Q value = 1

Table S1384. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
RPTN MUTATED	3	0	1
RPTN WILD-TYPE	181	162	158

'RPTN MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.837 (Fisher's exact test), Q value = 1

Table S1385. Gene #154: 'RPTN MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
RPTN MUTATED	1	1	1	1
RPTN WILD-TYPE	89	137	187	88

'ZNF148 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.199 (Fisher's exact test), Q value = 0.9

Table S1386. Gene #155: 'ZNF148 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ZNF148 MUTATED	0	5	0
ZNF148 WILD-TYPE	295	476	7

'ZNF148 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.168 (Fisher's exact test), Q value = 0.85

Table S1387. Gene #155: 'ZNF148 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ZNF148 MUTATED	2	0	0	3
ZNF148 WILD-TYPE	158	232	64	163

'ZNF148 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1388. Gene #155: 'ZNF148 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ZNF148 MUTATED	2	2	1
ZNF148 WILD-TYPE	225	233	191

'ZNF148 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.739 (Fisher's exact test), Q value = 1

Table S1389. Gene #155: 'ZNF148 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ZNF148 MUTATED	1	1	3
ZNF148 WILD-TYPE	195	189	265

'ZNF148 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.59 (Fisher's exact test), Q value = 1

Table S1390. Gene #155: 'ZNF148 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ZNF148 MUTATED	1	2	1	0
ZNF148 WILD-TYPE	135	105	182	83

'ZNF148 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.263 (Fisher's exact test), Q value = 1

Table S1391. Gene #155: 'ZNF148 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ZNF148 MUTATED	3	0	1
ZNF148 WILD-TYPE	219	184	102

'ZNF148 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.697 (Fisher's exact test), Q value = 1

Table S1392. Gene #155: 'ZNF148 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ZNF148 MUTATED	1	1	2
ZNF148 WILD-TYPE	183	161	157

'ZNF148 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.758 (Fisher's exact test), Q value = 1

Table S1393. Gene #155: 'ZNF148 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ZNF148 MUTATED	0	2	2	0
ZNF148 WILD-TYPE	90	136	186	89

'GFRA4 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.569 (Fisher's exact test), Q value = 1

Table S1394. Gene #156: 'GFRA4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
GFRA4 MUTATED	2	1	0
GFRA4 WILD-TYPE	293	480	7

'GFRA4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.547 (Fisher's exact test), Q value = 1

Table S1395. Gene #156: 'GFRA4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
GFRA4 MUTATED	2	1	0	0
GFRA4 WILD-TYPE	158	231	64	166

'SLC6A4 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1396. Gene #157: 'SLC6A4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SLC6A4 MUTATED	2	4	0
SLC6A4 WILD-TYPE	293	477	7

'SLC6A4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.509 (Fisher's exact test), Q value = 1

Table S1397. Gene #157: 'SLC6A4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SLC6A4 MUTATED	2	3	0	0
SLC6A4 WILD-TYPE	158	229	64	166

'SLC6A4 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.878 (Fisher's exact test), Q value = 1

Table S1398. Gene #157: 'SLC6A4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SLC6A4 MUTATED	2	3	1
SLC6A4 WILD-TYPE	225	232	191

'SLC6A4 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.16 (Fisher's exact test), Q value = 0.84

Table S1399. Gene #157: 'SLC6A4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SLC6A4 MUTATED	1	4	1
SLC6A4 WILD-TYPE	195	186	267

'SLC6A4 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.929 (Fisher's exact test), Q value = 1

Table S1400. Gene #157: 'SLC6A4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SLC6A4 MUTATED	2	1	2	0
SLC6A4 WILD-TYPE	134	106	181	83

'SLC6A4 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.847 (Fisher's exact test), Q value = 1

Table S1401. Gene #157: 'SLC6A4 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SLC6A4 MUTATED	3	1	1
SLC6A4 WILD-TYPE	219	183	102

'SLC6A4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.87 (Fisher's exact test), Q value = 1

Table S1402. Gene #157: 'SLC6A4 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SLC6A4 MUTATED	2	1	2
SLC6A4 WILD-TYPE	182	161	157

'SLC6A4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.214 (Fisher's exact test), Q value = 0.91

Table S1403. Gene #157: 'SLC6A4 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SLC6A4 MUTATED	2	0	3	0
SLC6A4 WILD-TYPE	88	138	185	89

'CCDC135 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0955 (Fisher's exact test), Q value = 0.61

Table S1404. Gene #158: 'CCDC135 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CCDC135 MUTATED	0	8	0
CCDC135 WILD-TYPE	295	473	7

'CCDC135 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.713 (Fisher's exact test), Q value = 1

Table S1405. Gene #158: 'CCDC135 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CCDC135 MUTATED	1	3	0	3
CCDC135 WILD-TYPE	159	229	64	163

'CCDC135 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.8 (Fisher's exact test), Q value = 1

Table S1406. Gene #158: 'CCDC135 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CCDC135 MUTATED	2	2	3
CCDC135 WILD-TYPE	225	233	189

'CCDC135 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.144 (Fisher's exact test), Q value = 0.8

Table S1407. Gene #158: 'CCDC135 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CCDC135 MUTATED	0	2	5
CCDC135 WILD-TYPE	196	188	263

'CCDC135 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.656 (Fisher's exact test), Q value = 1

Table S1408. Gene #158: 'CCDC135 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CCDC135 MUTATED	1	2	2	2
CCDC135 WILD-TYPE	135	105	181	81

'CCDC135 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1409. Gene #158: 'CCDC135 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CCDC135 MUTATED	3	3	1
CCDC135 WILD-TYPE	219	181	102

'CCDC135 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.806 (Fisher's exact test), Q value = 1

Table S1410. Gene #158: 'CCDC135 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CCDC135 MUTATED	2	2	3
CCDC135 WILD-TYPE	182	160	156

'CCDC135 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.736 (Fisher's exact test), Q value = 1

Table S1411. Gene #158: 'CCDC135 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CCDC135 MUTATED	1	2	4	0
CCDC135 WILD-TYPE	89	136	184	89

'RUVBL2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.186 (Fisher's exact test), Q value = 0.9

Table S1412. Gene #159: 'RUVBL2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
RUVBL2 MUTATED	3	1	0
RUVBL2 WILD-TYPE	292	480	7

'PYGL MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1413. Gene #160: 'PYGL MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PYGL MUTATED	1	3	0
PYGL WILD-TYPE	294	478	7

'PYGL MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1414. Gene #160: 'PYGL MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
PYGL MUTATED	1	1	0	1
PYGL WILD-TYPE	159	231	64	165

'PYGL MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.84 (Fisher's exact test), Q value = 1

Table S1415. Gene #160: 'PYGL MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PYGL MUTATED	2	1	1
PYGL WILD-TYPE	225	234	191

'PYGL MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1416. Gene #160: 'PYGL MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PYGL MUTATED	1	1	2
PYGL WILD-TYPE	195	189	266

'PYGL MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.523 (Fisher's exact test), Q value = 1

Table S1417. Gene #160: 'PYGL MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
PYGL MUTATED	0	1	1	1
PYGL WILD-TYPE	136	106	182	82

'PYGL MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.793 (Fisher's exact test), Q value = 1

Table S1418. Gene #160: 'PYGL MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
PYGL MUTATED	1	1	1
PYGL WILD-TYPE	221	183	102

'PYGL MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.208 (Fisher's exact test), Q value = 0.9

Table S1419. Gene #160: 'PYGL MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
PYGL MUTATED	0	1	2
PYGL WILD-TYPE	184	161	157

'PYGL MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1420. Gene #160: 'PYGL MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
PYGL MUTATED	0	1	2	0
PYGL WILD-TYPE	90	137	186	89

'ASXL2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.309 (Fisher's exact test), Q value = 1

Table S1421. Gene #161: 'ASXL2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ASXL2 MUTATED	0	3	0
ASXL2 WILD-TYPE	295	478	7

'ASXL2 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.351 (Fisher's exact test), Q value = 1

Table S1422. Gene #161: 'ASXL2 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ASXL2 MUTATED	1	0	0	2
ASXL2 WILD-TYPE	159	232	64	164

'ASXL2 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1423. Gene #161: 'ASXL2 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ASXL2 MUTATED	1	1	1
ASXL2 WILD-TYPE	226	234	191

'ASXL2 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.634 (Fisher's exact test), Q value = 1

Table S1424. Gene #161: 'ASXL2 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ASXL2 MUTATED	0	1	2
ASXL2 WILD-TYPE	196	189	266

'ASXL2 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.525 (Fisher's exact test), Q value = 1

Table S1425. Gene #161: 'ASXL2 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ASXL2 MUTATED	0	1	1	1
ASXL2 WILD-TYPE	136	106	182	82

'ASXL2 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.791 (Fisher's exact test), Q value = 1

Table S1426. Gene #161: 'ASXL2 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ASXL2 MUTATED	1	1	1
ASXL2 WILD-TYPE	221	183	102

'ASXL2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.208 (Fisher's exact test), Q value = 0.9

Table S1427. Gene #161: 'ASXL2 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ASXL2 MUTATED	0	1	2
ASXL2 WILD-TYPE	184	161	157

'ASXL2 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1428. Gene #161: 'ASXL2 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ASXL2 MUTATED	0	1	2	0
ASXL2 WILD-TYPE	90	137	186	89

'CIB1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.672 (Fisher's exact test), Q value = 1

Table S1429. Gene #162: 'CIB1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CIB1 MUTATED	1	4	0
CIB1 WILD-TYPE	294	477	7

'CIB1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1430. Gene #162: 'CIB1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CIB1 MUTATED	1	2	0	2
CIB1 WILD-TYPE	159	230	64	164

'CIB1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.689 (Fisher's exact test), Q value = 1

Table S1431. Gene #162: 'CIB1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CIB1 MUTATED	1	1	2
CIB1 WILD-TYPE	226	234	190

'CIB1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.312 (Fisher's exact test), Q value = 1

Table S1432. Gene #162: 'CIB1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CIB1 MUTATED	0	1	3
CIB1 WILD-TYPE	196	189	265

'CIB1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.217 (Fisher's exact test), Q value = 0.92

Table S1433. Gene #162: 'CIB1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CIB1 MUTATED	0	1	1	2
CIB1 WILD-TYPE	136	106	182	81

'CIB1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0444 (Fisher's exact test), Q value = 0.4

Table S1434. Gene #162: 'CIB1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CIB1 MUTATED	0	4	0
CIB1 WILD-TYPE	222	180	103

Figure S244. Get High-res Image Gene #162: 'CIB1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'CIB1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.118 (Fisher's exact test), Q value = 0.7

Table S1435. Gene #162: 'CIB1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CIB1 MUTATED	0	3	1
CIB1 WILD-TYPE	184	159	158

'CIB1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.323 (Fisher's exact test), Q value = 1

Table S1436. Gene #162: 'CIB1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CIB1 MUTATED	0	3	1	0
CIB1 WILD-TYPE	90	135	187	89

'REXO1 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.0526 (Fisher's exact test), Q value = 0.43

Table S1437. Gene #163: 'REXO1 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
REXO1 MUTATED	3	0	0	0
REXO1 WILD-TYPE	74	93	45	60

'REXO1 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.0718 (Fisher's exact test), Q value = 0.52

Table S1438. Gene #163: 'REXO1 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
REXO1 MUTATED	0	2	1
REXO1 WILD-TYPE	138	59	75

'REXO1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.221 (Fisher's exact test), Q value = 0.92

Table S1439. Gene #163: 'REXO1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
REXO1 MUTATED	5	3	0
REXO1 WILD-TYPE	290	478	7

'REXO1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.023 (Fisher's exact test), Q value = 0.26

Table S1440. Gene #163: 'REXO1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
REXO1 MUTATED	5	1	0	0
REXO1 WILD-TYPE	155	231	64	166

Figure S245. Get High-res Image Gene #163: 'REXO1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'REXO1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.54 (Fisher's exact test), Q value = 1

Table S1441. Gene #163: 'REXO1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
REXO1 MUTATED	3	1	1
REXO1 WILD-TYPE	224	234	191

'REXO1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1442. Gene #163: 'REXO1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
REXO1 MUTATED	2	1	2
REXO1 WILD-TYPE	194	189	266

'REXO1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.913 (Fisher's exact test), Q value = 1

Table S1443. Gene #163: 'REXO1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
REXO1 MUTATED	1	1	1	1
REXO1 WILD-TYPE	135	106	182	82

'REXO1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.339 (Fisher's exact test), Q value = 1

Table S1444. Gene #163: 'REXO1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
REXO1 MUTATED	1	1	2
REXO1 WILD-TYPE	221	183	101

'REXO1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.695 (Fisher's exact test), Q value = 1

Table S1445. Gene #163: 'REXO1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
REXO1 MUTATED	1	1	2
REXO1 WILD-TYPE	183	161	157

'REXO1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.357 (Fisher's exact test), Q value = 1

Table S1446. Gene #163: 'REXO1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
REXO1 MUTATED	0	0	3	1
REXO1 WILD-TYPE	90	138	185	88

'SOX4 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.448 (Fisher's exact test), Q value = 1

Table S1447. Gene #164: 'SOX4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SOX4 MUTATED	1	5	0
SOX4 WILD-TYPE	294	476	7

'SOX4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.316 (Fisher's exact test), Q value = 1

Table S1448. Gene #164: 'SOX4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SOX4 MUTATED	2	1	0	4
SOX4 WILD-TYPE	158	231	64	162

'SOX4 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.213 (Fisher's exact test), Q value = 0.91

Table S1449. Gene #164: 'SOX4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SOX4 MUTATED	3	4	0
SOX4 WILD-TYPE	224	231	192

'SOX4 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.579 (Fisher's exact test), Q value = 1

Table S1450. Gene #164: 'SOX4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SOX4 MUTATED	1	2	4
SOX4 WILD-TYPE	195	188	264

'SOX4 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.00732 (Fisher's exact test), Q value = 0.11

Table S1451. Gene #164: 'SOX4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SOX4 MUTATED	1	1	0	4
SOX4 WILD-TYPE	135	106	183	79

Figure S246. Get High-res Image Gene #164: 'SOX4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'SOX4 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.119 (Fisher's exact test), Q value = 0.7

Table S1452. Gene #164: 'SOX4 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SOX4 MUTATED	4	0	2
SOX4 WILD-TYPE	218	184	101

'SOX4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.331 (Fisher's exact test), Q value = 1

Table S1453. Gene #164: 'SOX4 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SOX4 MUTATED	1	4	1
SOX4 WILD-TYPE	183	158	158

'SOX4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.175 (Fisher's exact test), Q value = 0.87

Table S1454. Gene #164: 'SOX4 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SOX4 MUTATED	0	4	1	1
SOX4 WILD-TYPE	90	134	187	88

'GLYAT MUTATION STATUS' versus 'CN_CNMF'

P value = 0.668 (Fisher's exact test), Q value = 1

Table S1455. Gene #165: 'GLYAT MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
GLYAT MUTATED	1	4	0
GLYAT WILD-TYPE	294	477	7

'GLYAT MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.923 (Fisher's exact test), Q value = 1

Table S1456. Gene #165: 'GLYAT MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
GLYAT MUTATED	2	2	0	1
GLYAT WILD-TYPE	158	230	64	165

'GLYAT MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.388 (Fisher's exact test), Q value = 1

Table S1457. Gene #165: 'GLYAT MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
GLYAT MUTATED	2	3	0
GLYAT WILD-TYPE	225	232	192

'GLYAT MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.401 (Fisher's exact test), Q value = 1

Table S1458. Gene #165: 'GLYAT MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
GLYAT MUTATED	1	3	1
GLYAT WILD-TYPE	195	187	267

'GLYAT MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.193 (Fisher's exact test), Q value = 0.9

Table S1459. Gene #165: 'GLYAT MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
GLYAT MUTATED	1	2	0	1
GLYAT WILD-TYPE	135	105	183	82

'GLYAT MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.266 (Fisher's exact test), Q value = 1

Table S1460. Gene #165: 'GLYAT MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
GLYAT MUTATED	3	0	1
GLYAT WILD-TYPE	219	184	102

'GLYAT MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.837 (Fisher's exact test), Q value = 1

Table S1461. Gene #165: 'GLYAT MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
GLYAT MUTATED	1	2	1
GLYAT WILD-TYPE	183	160	158

'GLYAT MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.697 (Fisher's exact test), Q value = 1

Table S1462. Gene #165: 'GLYAT MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
GLYAT MUTATED	1	2	1	0
GLYAT WILD-TYPE	89	136	187	89

'LYPD4 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.398 (Fisher's exact test), Q value = 1

Table S1463. Gene #166: 'LYPD4 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
LYPD4 MUTATED	0	2	1	0
LYPD4 WILD-TYPE	77	91	44	60

'LYPD4 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.31 (Fisher's exact test), Q value = 1

Table S1464. Gene #166: 'LYPD4 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
LYPD4 MUTATED	1	0	2
LYPD4 WILD-TYPE	137	61	74

'LYPD4 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.402 (Fisher's exact test), Q value = 1

Table S1465. Gene #166: 'LYPD4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
LYPD4 MUTATED	3	2	0
LYPD4 WILD-TYPE	292	479	7

'LYPD4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.012 (Fisher's exact test), Q value = 0.17

Table S1466. Gene #166: 'LYPD4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
LYPD4 MUTATED	4	0	0	0
LYPD4 WILD-TYPE	156	232	64	166

Figure S247. Get High-res Image Gene #166: 'LYPD4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'LYPD4 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.4 (Fisher's exact test), Q value = 1

Table S1467. Gene #166: 'LYPD4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
LYPD4 MUTATED	2	0	1
LYPD4 WILD-TYPE	225	235	191

'LYPD4 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1468. Gene #166: 'LYPD4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
LYPD4 MUTATED	1	1	1
LYPD4 WILD-TYPE	195	189	267

'EPS8L1 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1469. Gene #167: 'EPS8L1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
EPS8L1 MUTATED	2	3	0
EPS8L1 WILD-TYPE	293	478	7

'EPS8L1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.546 (Fisher's exact test), Q value = 1

Table S1470. Gene #167: 'EPS8L1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
EPS8L1 MUTATED	2	2	0	0
EPS8L1 WILD-TYPE	158	230	64	166

'EPS8L1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.842 (Fisher's exact test), Q value = 1

Table S1471. Gene #167: 'EPS8L1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
EPS8L1 MUTATED	2	1	1
EPS8L1 WILD-TYPE	225	234	191

'EPS8L1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.696 (Fisher's exact test), Q value = 1

Table S1472. Gene #167: 'EPS8L1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
EPS8L1 MUTATED	1	2	1
EPS8L1 WILD-TYPE	195	188	267

'EPS8L1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.679 (Fisher's exact test), Q value = 1

Table S1473. Gene #167: 'EPS8L1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
EPS8L1 MUTATED	0	1	2	0
EPS8L1 WILD-TYPE	136	106	181	83

'EPS8L1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.797 (Fisher's exact test), Q value = 1

Table S1474. Gene #167: 'EPS8L1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
EPS8L1 MUTATED	1	1	1
EPS8L1 WILD-TYPE	221	183	102

'EPS8L1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.413 (Fisher's exact test), Q value = 1

Table S1475. Gene #167: 'EPS8L1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
EPS8L1 MUTATED	1	0	2
EPS8L1 WILD-TYPE	183	162	157

'EPS8L1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.588 (Fisher's exact test), Q value = 1

Table S1476. Gene #167: 'EPS8L1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
EPS8L1 MUTATED	1	0	2	0
EPS8L1 WILD-TYPE	89	138	186	89

'CNOT4 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.447 (Fisher's exact test), Q value = 1

Table S1477. Gene #168: 'CNOT4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CNOT4 MUTATED	1	5	0
CNOT4 WILD-TYPE	294	476	7

'CNOT4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.778 (Fisher's exact test), Q value = 1

Table S1478. Gene #168: 'CNOT4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CNOT4 MUTATED	1	2	1	1
CNOT4 WILD-TYPE	159	230	63	165

'CNOT4 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1479. Gene #168: 'CNOT4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CNOT4 MUTATED	2	2	1
CNOT4 WILD-TYPE	225	233	191

'CNOT4 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.191 (Fisher's exact test), Q value = 0.9

Table S1480. Gene #168: 'CNOT4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CNOT4 MUTATED	0	3	2
CNOT4 WILD-TYPE	196	187	266

'CNOT4 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.117 (Fisher's exact test), Q value = 0.7

Table S1481. Gene #168: 'CNOT4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CNOT4 MUTATED	0	3	1	1
CNOT4 WILD-TYPE	136	104	182	82

'CNOT4 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.116 (Fisher's exact test), Q value = 0.69

Table S1482. Gene #168: 'CNOT4 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CNOT4 MUTATED	1	1	3
CNOT4 WILD-TYPE	221	183	100

'CNOT4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.333 (Fisher's exact test), Q value = 1

Table S1483. Gene #168: 'CNOT4 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CNOT4 MUTATED	3	0	2
CNOT4 WILD-TYPE	181	162	157

'CNOT4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.454 (Fisher's exact test), Q value = 1

Table S1484. Gene #168: 'CNOT4 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CNOT4 MUTATED	0	3	2	0
CNOT4 WILD-TYPE	90	135	186	89

'MYH8 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.867 (Fisher's exact test), Q value = 1

Table S1485. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
MYH8 MUTATED	2	0	2	1
MYH8 WILD-TYPE	67	43	72	53

'MYH8 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.73 (Fisher's exact test), Q value = 1

Table S1486. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
MYH8 MUTATED	1	1	2	1
MYH8 WILD-TYPE	62	49	46	78

'MYH8 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.307 (Fisher's exact test), Q value = 1

Table S1487. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
MYH8 MUTATED	3	1	0	3
MYH8 WILD-TYPE	74	92	45	57

'MYH8 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.0868 (Fisher's exact test), Q value = 0.58

Table S1488. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
MYH8 MUTATED	1	3	3
MYH8 WILD-TYPE	137	58	73

'MYH8 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.48 (Fisher's exact test), Q value = 1

Table S1489. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
MYH8 MUTATED	10	11	0
MYH8 WILD-TYPE	285	470	7

'MYH8 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.199 (Fisher's exact test), Q value = 0.9

Table S1490. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
MYH8 MUTATED	8	7	0	3
MYH8 WILD-TYPE	152	225	64	163

'MYH8 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.263 (Fisher's exact test), Q value = 1

Table S1491. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
MYH8 MUTATED	8	3	6
MYH8 WILD-TYPE	219	232	186

'MYH8 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.426 (Fisher's exact test), Q value = 1

Table S1492. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
MYH8 MUTATED	5	7	5
MYH8 WILD-TYPE	191	183	263

'MYH8 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.854 (Fisher's exact test), Q value = 1

Table S1493. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
MYH8 MUTATED	4	4	4	2
MYH8 WILD-TYPE	132	103	179	81

'MYH8 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.252 (Fisher's exact test), Q value = 0.98

Table S1494. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
MYH8 MUTATED	6	3	5
MYH8 WILD-TYPE	216	181	98

'MYH8 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.839 (Fisher's exact test), Q value = 1

Table S1495. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
MYH8 MUTATED	4	5	5
MYH8 WILD-TYPE	180	157	154

'MYH8 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.773 (Fisher's exact test), Q value = 1

Table S1496. Gene #169: 'MYH8 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
MYH8 MUTATED	2	3	5	4
MYH8 WILD-TYPE	88	135	183	85

'DPYS MUTATION STATUS' versus 'CN_CNMF'

P value = 0.669 (Fisher's exact test), Q value = 1

Table S1497. Gene #170: 'DPYS MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
DPYS MUTATED	1	4	0
DPYS WILD-TYPE	294	477	7

'DPYS MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.661 (Fisher's exact test), Q value = 1

Table S1498. Gene #170: 'DPYS MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
DPYS MUTATED	0	2	0	2
DPYS WILD-TYPE	160	230	64	164

'DPYS MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.687 (Fisher's exact test), Q value = 1

Table S1499. Gene #170: 'DPYS MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
DPYS MUTATED	1	1	2
DPYS WILD-TYPE	226	234	190

'DPYS MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.311 (Fisher's exact test), Q value = 1

Table S1500. Gene #170: 'DPYS MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
DPYS MUTATED	0	1	3
DPYS WILD-TYPE	196	189	265

'DPYS MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1501. Gene #170: 'DPYS MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
DPYS MUTATED	1	1	2	0
DPYS WILD-TYPE	135	106	181	83

'DPYS MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.424 (Fisher's exact test), Q value = 1

Table S1502. Gene #170: 'DPYS MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
DPYS MUTATED	1	3	0
DPYS WILD-TYPE	221	181	103

'DPYS MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.12 (Fisher's exact test), Q value = 0.7

Table S1503. Gene #170: 'DPYS MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
DPYS MUTATED	0	3	1
DPYS WILD-TYPE	184	159	158

'DPYS MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.637 (Fisher's exact test), Q value = 1

Table S1504. Gene #170: 'DPYS MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
DPYS MUTATED	0	2	1	1
DPYS WILD-TYPE	90	136	187	88

'TLR7 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.173 (Fisher's exact test), Q value = 0.87

Table S1505. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
TLR7 MUTATED	0	2	1	0
TLR7 WILD-TYPE	69	41	73	54

'TLR7 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.482 (Fisher's exact test), Q value = 1

Table S1506. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
TLR7 MUTATED	1	1	1	0
TLR7 WILD-TYPE	62	49	47	79

'TLR7 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.762 (Fisher's exact test), Q value = 1

Table S1507. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
TLR7 MUTATED	1	2	1	0
TLR7 WILD-TYPE	76	91	44	60

'TLR7 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.674 (Fisher's exact test), Q value = 1

Table S1508. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
TLR7 MUTATED	2	0	2
TLR7 WILD-TYPE	136	61	74

'TLR7 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.558 (Fisher's exact test), Q value = 1

Table S1509. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
TLR7 MUTATED	5	5	0
TLR7 WILD-TYPE	290	476	7

'TLR7 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.128 (Fisher's exact test), Q value = 0.73

Table S1510. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
TLR7 MUTATED	6	3	0	1
TLR7 WILD-TYPE	154	229	64	165

'TLR7 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.675 (Fisher's exact test), Q value = 1

Table S1511. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
TLR7 MUTATED	4	2	2
TLR7 WILD-TYPE	223	233	190

'TLR7 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.736 (Fisher's exact test), Q value = 1

Table S1512. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
TLR7 MUTATED	3	3	2
TLR7 WILD-TYPE	193	187	266

'TLR7 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1513. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
TLR7 MUTATED	2	1	2	1
TLR7 WILD-TYPE	134	106	181	82

'TLR7 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.757 (Fisher's exact test), Q value = 1

Table S1514. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
TLR7 MUTATED	2	2	2
TLR7 WILD-TYPE	220	182	101

'TLR7 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.294 (Fisher's exact test), Q value = 1

Table S1515. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
TLR7 MUTATED	1	1	4
TLR7 WILD-TYPE	183	161	155

'TLR7 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.352 (Fisher's exact test), Q value = 1

Table S1516. Gene #171: 'TLR7 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
TLR7 MUTATED	1	0	4	1
TLR7 WILD-TYPE	89	138	184	88

'MYH11 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1517. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
MYH11 MUTATED	1	1	2	1
MYH11 WILD-TYPE	68	42	72	53

'MYH11 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.478 (Fisher's exact test), Q value = 1

Table S1518. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
MYH11 MUTATED	0	2	1	2
MYH11 WILD-TYPE	63	48	47	77

'MYH11 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.0741 (Fisher's exact test), Q value = 0.52

Table S1519. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
MYH11 MUTATED	1	1	3	0
MYH11 WILD-TYPE	76	92	42	60

'MYH11 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.513 (Fisher's exact test), Q value = 1

Table S1520. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
MYH11 MUTATED	4	0	1
MYH11 WILD-TYPE	134	61	75

'MYH11 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.809 (Fisher's exact test), Q value = 1

Table S1521. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
MYH11 MUTATED	6	8	0
MYH11 WILD-TYPE	289	473	7

'MYH11 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.936 (Fisher's exact test), Q value = 1

Table S1522. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
MYH11 MUTATED	3	3	1	3
MYH11 WILD-TYPE	157	229	63	163

'MYH11 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.925 (Fisher's exact test), Q value = 1

Table S1523. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
MYH11 MUTATED	4	3	3
MYH11 WILD-TYPE	223	232	189

'MYH11 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.613 (Fisher's exact test), Q value = 1

Table S1524. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
MYH11 MUTATED	3	4	3
MYH11 WILD-TYPE	193	186	265

'MYH11 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1525. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
MYH11 MUTATED	2	2	4	1
MYH11 WILD-TYPE	134	105	179	82

'MYH11 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.614 (Fisher's exact test), Q value = 1

Table S1526. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
MYH11 MUTATED	3	3	3
MYH11 WILD-TYPE	219	181	100

'MYH11 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.586 (Fisher's exact test), Q value = 1

Table S1527. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
MYH11 MUTATED	2	3	4
MYH11 WILD-TYPE	182	159	155

'MYH11 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.605 (Fisher's exact test), Q value = 1

Table S1528. Gene #172: 'MYH11 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
MYH11 MUTATED	0	3	4	2
MYH11 WILD-TYPE	90	135	184	87

'SLC9A4 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.097 (Fisher's exact test), Q value = 0.62

Table S1529. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
SLC9A4 MUTATED	0	2	3	0
SLC9A4 WILD-TYPE	69	41	71	54

'SLC9A4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.73 (Fisher's exact test), Q value = 1

Table S1530. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
SLC9A4 MUTATED	1	1	2	1
SLC9A4 WILD-TYPE	62	49	46	78

'SLC9A4 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.406 (Fisher's exact test), Q value = 1

Table S1531. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
SLC9A4 MUTATED	1	1	1	3
SLC9A4 WILD-TYPE	76	92	44	57

'SLC9A4 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.75 (Fisher's exact test), Q value = 1

Table S1532. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
SLC9A4 MUTATED	3	2	1
SLC9A4 WILD-TYPE	135	59	75

'SLC9A4 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.777 (Fisher's exact test), Q value = 1

Table S1533. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SLC9A4 MUTATED	5	6	0
SLC9A4 WILD-TYPE	290	475	7

'SLC9A4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.609 (Fisher's exact test), Q value = 1

Table S1534. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SLC9A4 MUTATED	3	2	0	1
SLC9A4 WILD-TYPE	157	230	64	165

'SLC9A4 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.116 (Fisher's exact test), Q value = 0.69

Table S1535. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SLC9A4 MUTATED	5	3	0
SLC9A4 WILD-TYPE	222	232	192

'SLC9A4 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.248 (Fisher's exact test), Q value = 0.98

Table S1536. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SLC9A4 MUTATED	4	3	1
SLC9A4 WILD-TYPE	192	187	267

'SLC9A4 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.274 (Fisher's exact test), Q value = 1

Table S1537. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SLC9A4 MUTATED	2	1	0	1
SLC9A4 WILD-TYPE	134	106	183	82

'SLC9A4 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.265 (Fisher's exact test), Q value = 1

Table S1538. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SLC9A4 MUTATED	3	0	1
SLC9A4 WILD-TYPE	219	184	102

'SLC9A4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.304 (Fisher's exact test), Q value = 1

Table S1539. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SLC9A4 MUTATED	0	2	1
SLC9A4 WILD-TYPE	184	160	158

'SLC9A4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.671 (Fisher's exact test), Q value = 1

Table S1540. Gene #173: 'SLC9A4 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SLC9A4 MUTATED	0	2	1	0
SLC9A4 WILD-TYPE	90	136	187	89

'SEMA3C MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.481 (Fisher's exact test), Q value = 1

Table S1541. Gene #174: 'SEMA3C MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
SEMA3C MUTATED	3	4	2	2
SEMA3C WILD-TYPE	66	39	72	52

'SEMA3C MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.175 (Fisher's exact test), Q value = 0.87

Table S1542. Gene #174: 'SEMA3C MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
SEMA3C MUTATED	1	5	1	4
SEMA3C WILD-TYPE	62	45	47	75

'SEMA3C MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.119 (Fisher's exact test), Q value = 0.7

Table S1543. Gene #174: 'SEMA3C MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
SEMA3C MUTATED	3	7	1	0
SEMA3C WILD-TYPE	74	86	44	60

'SEMA3C MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.85 (Fisher's exact test), Q value = 1

Table S1544. Gene #174: 'SEMA3C MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
SEMA3C MUTATED	5	2	4
SEMA3C WILD-TYPE	133	59	72

'SEMA3C MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00112 (Fisher's exact test), Q value = 0.025

Table S1545. Gene #174: 'SEMA3C MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SEMA3C MUTATED	9	2	1
SEMA3C WILD-TYPE	286	479	6

Figure S248. Get High-res Image Gene #174: 'SEMA3C MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'SEMA3C MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.00048 (Fisher's exact test), Q value = 0.012

Table S1546. Gene #174: 'SEMA3C MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SEMA3C MUTATED	9	1	0
SEMA3C WILD-TYPE	218	234	192

Figure S249. Get High-res Image Gene #174: 'SEMA3C MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'SEMA3C MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00086 (Fisher's exact test), Q value = 0.021

Table S1547. Gene #174: 'SEMA3C MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SEMA3C MUTATED	8	2	0
SEMA3C WILD-TYPE	188	188	268

Figure S250. Get High-res Image Gene #174: 'SEMA3C MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'PAN3 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.563 (Fisher's exact test), Q value = 1

Table S1548. Gene #175: 'PAN3 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
PAN3 MUTATED	3	0	1	1
PAN3 WILD-TYPE	66	43	73	53

'PAN3 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.303 (Fisher's exact test), Q value = 1

Table S1549. Gene #175: 'PAN3 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
PAN3 MUTATED	2	2	1	0
PAN3 WILD-TYPE	61	48	47	79

'PAN3 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.597 (Fisher's exact test), Q value = 1

Table S1550. Gene #175: 'PAN3 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
PAN3 MUTATED	2	3	1	0
PAN3 WILD-TYPE	75	90	44	60

'PAN3 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.649 (Fisher's exact test), Q value = 1

Table S1551. Gene #175: 'PAN3 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
PAN3 MUTATED	2	2	2
PAN3 WILD-TYPE	136	59	74

'PAN3 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.47 (Fisher's exact test), Q value = 1

Table S1552. Gene #175: 'PAN3 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PAN3 MUTATED	4	3	0
PAN3 WILD-TYPE	291	478	7

'PAN3 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.399 (Fisher's exact test), Q value = 1

Table S1553. Gene #175: 'PAN3 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
PAN3 MUTATED	2	0	1
PAN3 WILD-TYPE	225	235	191

'PAN3 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.487 (Fisher's exact test), Q value = 1

Table S1554. Gene #175: 'PAN3 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
PAN3 MUTATED	2	0	1
PAN3 WILD-TYPE	194	190	267

'KRT15 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.737 (Fisher's exact test), Q value = 1

Table S1555. Gene #176: 'KRT15 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
KRT15 MUTATED	2	6	0
KRT15 WILD-TYPE	293	475	7

'KRT15 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.482 (Fisher's exact test), Q value = 1

Table S1556. Gene #176: 'KRT15 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
KRT15 MUTATED	0	3	1	2
KRT15 WILD-TYPE	160	229	63	164

'KRT15 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.46 (Fisher's exact test), Q value = 1

Table S1557. Gene #176: 'KRT15 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
KRT15 MUTATED	3	1	3
KRT15 WILD-TYPE	224	234	189

'KRT15 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1558. Gene #176: 'KRT15 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
KRT15 MUTATED	2	2	3
KRT15 WILD-TYPE	194	188	265

'KRT15 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.518 (Fisher's exact test), Q value = 1

Table S1559. Gene #176: 'KRT15 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
KRT15 MUTATED	3	0	2	1
KRT15 WILD-TYPE	133	107	181	82

'KRT15 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.868 (Fisher's exact test), Q value = 1

Table S1560. Gene #176: 'KRT15 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
KRT15 MUTATED	2	3	1
KRT15 WILD-TYPE	220	181	102

'KRT15 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1561. Gene #176: 'KRT15 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
KRT15 MUTATED	2	2	2
KRT15 WILD-TYPE	182	160	157

'KRT15 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1562. Gene #176: 'KRT15 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
KRT15 MUTATED	1	2	2	1
KRT15 WILD-TYPE	89	136	186	88

'FMR1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.198 (Fisher's exact test), Q value = 0.9

Table S1563. Gene #177: 'FMR1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
FMR1 MUTATED	0	5	0
FMR1 WILD-TYPE	295	476	7

'FMR1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.779 (Fisher's exact test), Q value = 1

Table S1564. Gene #177: 'FMR1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
FMR1 MUTATED	1	2	1	1
FMR1 WILD-TYPE	159	230	63	165

'FMR1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.332 (Fisher's exact test), Q value = 1

Table S1565. Gene #177: 'FMR1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
FMR1 MUTATED	3	2	0
FMR1 WILD-TYPE	224	233	192

'FMR1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00187 (Fisher's exact test), Q value = 0.038

Table S1566. Gene #177: 'FMR1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
FMR1 MUTATED	0	5	0
FMR1 WILD-TYPE	196	185	268

Figure S251. Get High-res Image Gene #177: 'FMR1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'FMR1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.241 (Fisher's exact test), Q value = 0.96

Table S1567. Gene #177: 'FMR1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
FMR1 MUTATED	1	3	1	0
FMR1 WILD-TYPE	135	104	182	83

'FMR1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.36 (Fisher's exact test), Q value = 1

Table S1568. Gene #177: 'FMR1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
FMR1 MUTATED	1	2	2
FMR1 WILD-TYPE	221	182	101

'FMR1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.335 (Fisher's exact test), Q value = 1

Table S1569. Gene #177: 'FMR1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
FMR1 MUTATED	3	0	2
FMR1 WILD-TYPE	181	162	157

'FMR1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1570. Gene #177: 'FMR1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
FMR1 MUTATED	1	1	2	1
FMR1 WILD-TYPE	89	137	186	88

'PPP2R5E MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1571. Gene #178: 'PPP2R5E MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
PPP2R5E MUTATED	1	2	0
PPP2R5E WILD-TYPE	294	479	7

'ZC3H11A MUTATION STATUS' versus 'CN_CNMF'

P value = 0.405 (Fisher's exact test), Q value = 1

Table S1572. Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
ZC3H11A MUTATED	3	2	0
ZC3H11A WILD-TYPE	292	479	7

'ZC3H11A MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0174 (Fisher's exact test), Q value = 0.22

Table S1573. Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
ZC3H11A MUTATED	4	0	1	0
ZC3H11A WILD-TYPE	156	232	63	166

Figure S252. Get High-res Image Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'ZC3H11A MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.00724 (Fisher's exact test), Q value = 0.11

Table S1574. Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
ZC3H11A MUTATED	5	0	0
ZC3H11A WILD-TYPE	222	235	192

Figure S253. Get High-res Image Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'ZC3H11A MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0386 (Fisher's exact test), Q value = 0.37

Table S1575. Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
ZC3H11A MUTATED	4	1	0
ZC3H11A WILD-TYPE	192	189	268

Figure S254. Get High-res Image Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'ZC3H11A MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.24 (Fisher's exact test), Q value = 0.96

Table S1576. Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
ZC3H11A MUTATED	1	3	1	0
ZC3H11A WILD-TYPE	135	104	182	83

'ZC3H11A MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.0068 (Fisher's exact test), Q value = 0.11

Table S1577. Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
ZC3H11A MUTATED	1	0	4
ZC3H11A WILD-TYPE	221	184	99

Figure S255. Get High-res Image Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'ZC3H11A MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.332 (Fisher's exact test), Q value = 1

Table S1578. Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
ZC3H11A MUTATED	3	0	2
ZC3H11A WILD-TYPE	181	162	157

'ZC3H11A MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0668 (Fisher's exact test), Q value = 0.49

Table S1579. Gene #179: 'ZC3H11A MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
ZC3H11A MUTATED	1	0	1	3
ZC3H11A WILD-TYPE	89	138	187	86

'DST MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.835 (Fisher's exact test), Q value = 1

Table S1580. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
DST MUTATED	2	0	1	1
DST WILD-TYPE	67	43	73	53

'DST MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1581. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
DST MUTATED	1	1	1	1
DST WILD-TYPE	62	49	47	78

'DST MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.181 (Fisher's exact test), Q value = 0.89

Table S1582. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
DST MUTATED	2	0	0	2
DST WILD-TYPE	75	93	45	58

'DST MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.813 (Fisher's exact test), Q value = 1

Table S1583. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
DST MUTATED	3	0	1
DST WILD-TYPE	135	61	75

'DST MUTATION STATUS' versus 'CN_CNMF'

P value = 0.821 (Fisher's exact test), Q value = 1

Table S1584. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
DST MUTATED	5	10	0
DST WILD-TYPE	290	471	7

'DST MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.726 (Fisher's exact test), Q value = 1

Table S1585. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
DST MUTATED	2	4	1	5
DST WILD-TYPE	158	228	63	161

'DST MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.905 (Fisher's exact test), Q value = 1

Table S1586. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
DST MUTATED	6	5	5
DST WILD-TYPE	221	230	187

'DST MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1587. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
DST MUTATED	5	4	7
DST WILD-TYPE	191	186	261

'DST MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.416 (Fisher's exact test), Q value = 1

Table S1588. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
DST MUTATED	2	5	4	1
DST WILD-TYPE	134	102	179	82

'DST MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.934 (Fisher's exact test), Q value = 1

Table S1589. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
DST MUTATED	5	5	2
DST WILD-TYPE	217	179	101

'DST MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.411 (Fisher's exact test), Q value = 1

Table S1590. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
DST MUTATED	3	3	6
DST WILD-TYPE	181	159	153

'DST MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.273 (Fisher's exact test), Q value = 1

Table S1591. Gene #180: 'DST MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
DST MUTATED	3	1	7	1
DST WILD-TYPE	87	137	181	88

'NKPD1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0143 (Fisher's exact test), Q value = 0.19

Table S1592. Gene #181: 'NKPD1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
NKPD1 MUTATED	0	2	1
NKPD1 WILD-TYPE	295	479	6

Figure S256. Get High-res Image Gene #181: 'NKPD1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'NKPD1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.192 (Fisher's exact test), Q value = 0.9

Table S1593. Gene #181: 'NKPD1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
NKPD1 MUTATED	0	2	1	0
NKPD1 WILD-TYPE	160	230	63	166

'NKPD1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1594. Gene #181: 'NKPD1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
NKPD1 MUTATED	1	1	1
NKPD1 WILD-TYPE	226	234	191

'NKPD1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.376 (Fisher's exact test), Q value = 1

Table S1595. Gene #181: 'NKPD1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
NKPD1 MUTATED	0	2	1
NKPD1 WILD-TYPE	196	188	267

'NKPD1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.68 (Fisher's exact test), Q value = 1

Table S1596. Gene #181: 'NKPD1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
NKPD1 MUTATED	0	1	2	0
NKPD1 WILD-TYPE	136	106	181	83

'NKPD1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.793 (Fisher's exact test), Q value = 1

Table S1597. Gene #181: 'NKPD1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
NKPD1 MUTATED	1	1	1
NKPD1 WILD-TYPE	221	183	102

'NKPD1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.209 (Fisher's exact test), Q value = 0.9

Table S1598. Gene #181: 'NKPD1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
NKPD1 MUTATED	0	1	2
NKPD1 WILD-TYPE	184	161	157

'NKPD1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.776 (Fisher's exact test), Q value = 1

Table S1599. Gene #181: 'NKPD1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
NKPD1 MUTATED	0	1	1	1
NKPD1 WILD-TYPE	90	137	187	88

'CTBP2 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.576 (Fisher's exact test), Q value = 1

Table S1600. Gene #182: 'CTBP2 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CTBP2 MUTATED	2	1	0
CTBP2 WILD-TYPE	293	480	7

'SEC14L4 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0135 (Fisher's exact test), Q value = 0.18

Table S1601. Gene #183: 'SEC14L4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SEC14L4 MUTATED	0	2	1
SEC14L4 WILD-TYPE	295	479	6

Figure S257. Get High-res Image Gene #183: 'SEC14L4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'SEC14L4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.733 (Fisher's exact test), Q value = 1

Table S1602. Gene #183: 'SEC14L4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SEC14L4 MUTATED	1	2	0	0
SEC14L4 WILD-TYPE	159	230	64	166

'SEC14L4 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.644 (Fisher's exact test), Q value = 1

Table S1603. Gene #183: 'SEC14L4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SEC14L4 MUTATED	2	1	0
SEC14L4 WILD-TYPE	225	234	192

'SEC14L4 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.196 (Fisher's exact test), Q value = 0.9

Table S1604. Gene #183: 'SEC14L4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SEC14L4 MUTATED	1	2	0
SEC14L4 WILD-TYPE	195	188	268

'SEC14L4 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.191 (Fisher's exact test), Q value = 0.9

Table S1605. Gene #183: 'SEC14L4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SEC14L4 MUTATED	1	2	0	0
SEC14L4 WILD-TYPE	135	105	183	83

'SEC14L4 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.154 (Fisher's exact test), Q value = 0.83

Table S1606. Gene #183: 'SEC14L4 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SEC14L4 MUTATED	1	0	2
SEC14L4 WILD-TYPE	221	184	101

'SEC14L4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.112 (Fisher's exact test), Q value = 0.68

Table S1607. Gene #183: 'SEC14L4 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SEC14L4 MUTATED	3	0	0
SEC14L4 WILD-TYPE	181	162	159

'SEC14L4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0264 (Fisher's exact test), Q value = 0.28

Table S1608. Gene #183: 'SEC14L4 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SEC14L4 MUTATED	1	0	0	2
SEC14L4 WILD-TYPE	89	138	188	87

Figure S258. Get High-res Image Gene #183: 'SEC14L4 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'KEL MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.548 (Fisher's exact test), Q value = 1

Table S1609. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
KEL MUTATED	3	3	7	2
KEL WILD-TYPE	66	40	67	52

'KEL MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.212 (Fisher's exact test), Q value = 0.91

Table S1610. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
KEL MUTATED	3	1	6	5
KEL WILD-TYPE	60	49	42	74

'KEL MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.722 (Fisher's exact test), Q value = 1

Table S1611. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
KEL MUTATED	3	5	2	5
KEL WILD-TYPE	74	88	43	55

'KEL MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.886 (Fisher's exact test), Q value = 1

Table S1612. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
KEL MUTATED	7	3	5
KEL WILD-TYPE	131	58	71

'KEL MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00103 (Fisher's exact test), Q value = 0.023

Table S1613. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
KEL MUTATED	18	6	0
KEL WILD-TYPE	277	475	7

Figure S259. Get High-res Image Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

'KEL MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.00103 (Fisher's exact test), Q value = 0.023

Table S1614. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
KEL MUTATED	12	2	1	2
KEL WILD-TYPE	148	230	63	164

Figure S260. Get High-res Image Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

'KEL MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 3e-05 (Fisher's exact test), Q value = 0.001

Table S1615. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
KEL MUTATED	16	1	2
KEL WILD-TYPE	211	234	190

Figure S261. Get High-res Image Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

'KEL MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.00204 (Fisher's exact test), Q value = 0.041

Table S1616. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
KEL MUTATED	13	3	3
KEL WILD-TYPE	183	187	265

Figure S262. Get High-res Image Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

'KEL MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.041 (Fisher's exact test), Q value = 0.38

Table S1617. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
KEL MUTATED	3	5	1	0
KEL WILD-TYPE	133	102	182	83

Figure S263. Get High-res Image Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

'KEL MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.00015 (Fisher's exact test), Q value = 0.0042

Table S1618. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
KEL MUTATED	2	0	7
KEL WILD-TYPE	220	184	96

Figure S264. Get High-res Image Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

'KEL MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.148 (Fisher's exact test), Q value = 0.81

Table S1619. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
KEL MUTATED	6	1	2
KEL WILD-TYPE	178	161	157

'KEL MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.00473 (Fisher's exact test), Q value = 0.083

Table S1620. Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
KEL MUTATED	0	1	2	6
KEL WILD-TYPE	90	137	186	83

Figure S265. Get High-res Image Gene #184: 'KEL MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

'SSTR4 MUTATION STATUS' versus 'MRNA_CNMF'

P value = 0.599 (Fisher's exact test), Q value = 1

Table S1621. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	69	43	74	54
SSTR4 MUTATED	2	0	2	0
SSTR4 WILD-TYPE	67	43	72	54

'SSTR4 MUTATION STATUS' versus 'MRNA_CHIERARCHICAL'

P value = 0.713 (Fisher's exact test), Q value = 1

Table S1622. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	63	50	48	79
SSTR4 MUTATED	2	0	1	1
SSTR4 WILD-TYPE	61	50	47	78

'SSTR4 MUTATION STATUS' versus 'MIR_CNMF'

P value = 0.445 (Fisher's exact test), Q value = 1

Table S1623. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	77	93	45	60
SSTR4 MUTATED	2	0	1	1
SSTR4 WILD-TYPE	75	93	44	59

'SSTR4 MUTATION STATUS' versus 'MIR_CHIERARCHICAL'

P value = 0.259 (Fisher's exact test), Q value = 1

Table S1624. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	138	61	76
SSTR4 MUTATED	2	2	0
SSTR4 WILD-TYPE	136	59	76

'SSTR4 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.779 (Fisher's exact test), Q value = 1

Table S1625. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SSTR4 MUTATED	5	6	0
SSTR4 WILD-TYPE	290	475	7

'SSTR4 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.437 (Fisher's exact test), Q value = 1

Table S1626. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SSTR4 MUTATED	4	3	0	1
SSTR4 WILD-TYPE	156	229	64	165

'SSTR4 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.229 (Fisher's exact test), Q value = 0.94

Table S1627. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SSTR4 MUTATED	5	1	3
SSTR4 WILD-TYPE	222	234	189

'SSTR4 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.494 (Fisher's exact test), Q value = 1

Table S1628. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SSTR4 MUTATED	4	3	2
SSTR4 WILD-TYPE	192	187	266

'SSTR4 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.768 (Fisher's exact test), Q value = 1

Table S1629. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SSTR4 MUTATED	2	2	3	0
SSTR4 WILD-TYPE	134	105	180	83

'SSTR4 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.332 (Fisher's exact test), Q value = 1

Table S1630. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SSTR4 MUTATED	2	2	3
SSTR4 WILD-TYPE	220	182	100

'SSTR4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.642 (Fisher's exact test), Q value = 1

Table S1631. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SSTR4 MUTATED	3	1	3
SSTR4 WILD-TYPE	181	161	156

'SSTR4 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.873 (Fisher's exact test), Q value = 1

Table S1632. Gene #185: 'SSTR4 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SSTR4 MUTATED	1	2	2	2
SSTR4 WILD-TYPE	89	136	186	87

'SMARCB1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.328 (Fisher's exact test), Q value = 1

Table S1633. Gene #186: 'SMARCB1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SMARCB1 MUTATED	0	4	0
SMARCB1 WILD-TYPE	295	477	7

'SMARCB1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1634. Gene #186: 'SMARCB1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SMARCB1 MUTATED	1	2	0	1
SMARCB1 WILD-TYPE	159	230	64	165

'SMARCB1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.686 (Fisher's exact test), Q value = 1

Table S1635. Gene #186: 'SMARCB1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SMARCB1 MUTATED	1	1	2
SMARCB1 WILD-TYPE	226	234	190

'SMARCB1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.145 (Fisher's exact test), Q value = 0.8

Table S1636. Gene #186: 'SMARCB1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SMARCB1 MUTATED	0	3	1
SMARCB1 WILD-TYPE	196	187	267

'SMARCB1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.44 (Fisher's exact test), Q value = 1

Table S1637. Gene #186: 'SMARCB1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SMARCB1 MUTATED	0	1	3	0
SMARCB1 WILD-TYPE	136	106	180	83

'SMARCB1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.682 (Fisher's exact test), Q value = 1

Table S1638. Gene #186: 'SMARCB1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SMARCB1 MUTATED	1	2	1
SMARCB1 WILD-TYPE	221	182	102

'SMARCB1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0768 (Fisher's exact test), Q value = 0.53

Table S1639. Gene #186: 'SMARCB1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SMARCB1 MUTATED	0	1	3
SMARCB1 WILD-TYPE	184	161	156

'SMARCB1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.396 (Fisher's exact test), Q value = 1

Table S1640. Gene #186: 'SMARCB1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SMARCB1 MUTATED	1	0	3	0
SMARCB1 WILD-TYPE	89	138	185	89

'CAPN11 MUTATION STATUS' versus 'CN_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S1641. Gene #187: 'CAPN11 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
CAPN11 MUTATED	2	3	0
CAPN11 WILD-TYPE	293	478	7

'CAPN11 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.734 (Fisher's exact test), Q value = 1

Table S1642. Gene #187: 'CAPN11 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
CAPN11 MUTATED	1	2	0	0
CAPN11 WILD-TYPE	159	230	64	166

'CAPN11 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.843 (Fisher's exact test), Q value = 1

Table S1643. Gene #187: 'CAPN11 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
CAPN11 MUTATED	2	1	1
CAPN11 WILD-TYPE	225	234	191

'CAPN11 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.48 (Fisher's exact test), Q value = 1

Table S1644. Gene #187: 'CAPN11 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
CAPN11 MUTATED	0	2	2
CAPN11 WILD-TYPE	196	188	266

'CAPN11 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.523 (Fisher's exact test), Q value = 1

Table S1645. Gene #187: 'CAPN11 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
CAPN11 MUTATED	0	1	1	1
CAPN11 WILD-TYPE	136	106	182	82

'CAPN11 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.793 (Fisher's exact test), Q value = 1

Table S1646. Gene #187: 'CAPN11 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
CAPN11 MUTATED	1	1	1
CAPN11 WILD-TYPE	221	183	102

'CAPN11 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.207 (Fisher's exact test), Q value = 0.9

Table S1647. Gene #187: 'CAPN11 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
CAPN11 MUTATED	0	1	2
CAPN11 WILD-TYPE	184	161	157

'CAPN11 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S1648. Gene #187: 'CAPN11 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
CAPN11 MUTATED	0	1	2	0
CAPN11 WILD-TYPE	90	137	186	89

'SH3KBP1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.332 (Fisher's exact test), Q value = 1

Table S1649. Gene #188: 'SH3KBP1 MUTATION STATUS' versus Molecular Subtype #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	295	481	7
SH3KBP1 MUTATED	0	4	0
SH3KBP1 WILD-TYPE	295	477	7

'SH3KBP1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.135 (Fisher's exact test), Q value = 0.76

Table S1650. Gene #188: 'SH3KBP1 MUTATION STATUS' versus Molecular Subtype #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	160	232	64	166
SH3KBP1 MUTATED	1	0	0	3
SH3KBP1 WILD-TYPE	159	232	64	163

'SH3KBP1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.688 (Fisher's exact test), Q value = 1

Table S1651. Gene #188: 'SH3KBP1 MUTATION STATUS' versus Molecular Subtype #7: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	227	235	192
SH3KBP1 MUTATED	1	1	2
SH3KBP1 WILD-TYPE	226	234	190

'SH3KBP1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.314 (Fisher's exact test), Q value = 1

Table S1652. Gene #188: 'SH3KBP1 MUTATION STATUS' versus Molecular Subtype #8: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	196	190	268
SH3KBP1 MUTATED	0	1	3
SH3KBP1 WILD-TYPE	196	189	265

'SH3KBP1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.644 (Fisher's exact test), Q value = 1

Table S1653. Gene #188: 'SH3KBP1 MUTATION STATUS' versus Molecular Subtype #9: 'MIRSEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	136	107	183	83
SH3KBP1 MUTATED	0	1	2	1
SH3KBP1 WILD-TYPE	136	106	181	82

'SH3KBP1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.682 (Fisher's exact test), Q value = 1

Table S1654. Gene #188: 'SH3KBP1 MUTATION STATUS' versus Molecular Subtype #10: 'MIRSEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	222	184	103
SH3KBP1 MUTATED	1	2	1
SH3KBP1 WILD-TYPE	221	182	102

'SH3KBP1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.332 (Fisher's exact test), Q value = 1

Table S1655. Gene #188: 'SH3KBP1 MUTATION STATUS' versus Molecular Subtype #11: 'MIRSEQ_MATURE_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	184	162	159
SH3KBP1 MUTATED	0	2	2
SH3KBP1 WILD-TYPE	184	160	157

'SH3KBP1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.578 (Fisher's exact test), Q value = 1

Table S1656. Gene #188: 'SH3KBP1 MUTATION STATUS' versus Molecular Subtype #12: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	90	138	188	89
SH3KBP1 MUTATED	0	1	3	0
SH3KBP1 WILD-TYPE	90	137	185	89

Methods & Data

Input

Mutation data file = sample_sig_gene_table.txt from Mutsig_2CV pipeline
Processed Mutation data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/GBMLGG-TP/15650473/transformed.cor.cli.txt
Molecular subtypes file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_mergedClustering/GBMLGG-TP/15249296/GBMLGG-TP.transferedmergedcluster.txt
Number of patients = 796
Number of significantly mutated genes = 188
Number of Molecular subtypes = 12
Exclude genes that fewer than K tumors have mutations, K = 3

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References

[1] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)

[2] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)

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