rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(3), CCNA2(1), CCND1(4), CCNE1(2), CCNE2(2), CDK2(1), CDK4(1), CDKN1B(4), CDKN2A(6), E2F1(1), E2F2(1), E2F4(1), PRB1(2)	10572211	29	25	28	1	5	1	6	7	10	0	0.00211	0.00819	1.000
2	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(8), IFNG(2), IL12B(4), IL18(3)	3542953	17	13	17	3	4	3	2	6	2	0	0.182	0.0488	1.000
3	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(3)	2399460	9	9	9	2	4	3	0	1	1	0	0.348	0.0490	1.000
4	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(1), CCND1(4), CDK2(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CFL1(1), E2F1(1), E2F2(1), MDM2(5), PRB1(2)	8951305	29	24	28	4	6	2	5	5	11	0	0.0428	0.0570	1.000
5	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(3)	854859	3	3	3	1	2	1	0	0	0	0	0.562	0.108	1.000
6	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3E(2), CD3G(1)	1351852	4	4	4	1	0	1	1	1	1	0	0.574	0.122	1.000
7	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACPP(4), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(3), TYR(5)	11508628	22	19	22	1	8	2	4	6	2	0	0.00987	0.136	1.000
8	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(2), HLA-DRA(4), HLA-DRB1(1)	2824898	9	7	8	1	4	1	0	3	1	0	0.158	0.180	1.000
9	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(3), HGD(5)	2645677	10	6	10	2	4	0	1	2	3	0	0.308	0.189	1.000
10	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(2), GALT(1), TGDS(2), UGDH(1), UXS1(4)	4580573	10	9	10	1	1	2	3	2	2	0	0.162	0.195	1.000
11	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(3), CCNE1(2), CDC34(2), CDK2(1), CUL1(4), E2F1(1), SKP2(4), TFDP1(1)	8080361	18	16	18	2	2	4	3	6	3	0	0.0984	0.217	1.000
12	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(2), CCL5(1), CCR3(2), CSF2(2), HLA-DRA(4), HLA-DRB1(1), IL3(2), IL5(1)	3611520	15	11	15	3	4	3	1	4	3	0	0.226	0.219	1.000
13	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CCNE1(2), CDK2(1), CDKN1B(4), CUL1(4), E2F1(1), RBX1(1), SKP2(4), TFDP1(1), UBE2M(2)	8096124	20	18	20	3	1	5	4	5	5	0	0.114	0.225	1.000
14	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(3), GGPS1(1), IDI1(2), IDI2(1), SQLE(1)	5066632	9	8	9	0	1	0	5	1	2	0	0.0921	0.341	1.000
15	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(2), COQ5(3), COQ6(2), NDUFA12(1), NDUFB11(1)	4785378	10	8	10	1	2	4	0	2	2	0	0.184	0.346	1.000
16	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(3), IDI1(2), SQLE(1)	3785468	7	6	7	0	1	0	4	0	2	0	0.163	0.367	1.000
17	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(3)	2158410	5	5	5	1	3	1	0	1	0	0	0.461	0.381	1.000
18	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(2), GALT(1), TGDS(2), UGDH(1), UGP2(1), UXS1(4)	5827733	11	9	11	1	1	2	3	3	2	0	0.139	0.388	1.000
19	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5), SUCLA2(1)	2508918	6	5	6	0	2	2	0	2	0	0	0.133	0.393	1.000
20	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(2), CDC34(2), CDK2(1), CUL1(4), E2F1(1), FBXW7(6), TFDP1(1)	7751397	17	14	17	2	4	4	1	5	3	0	0.0845	0.402	1.000
21	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(2), CCR3(2), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL1B(3), IL5(1), IL5RA(3), IL6(2)	6346628	20	15	20	4	6	4	0	8	2	0	0.137	0.451	1.000
22	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(3), NR0B2(1), NR1H3(5), NR1H4(3), RXRA(4)	6471064	18	17	16	4	7	4	2	4	1	0	0.138	0.456	1.000
23	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(12), RANGAP1(2)	9998529	15	13	15	1	3	2	3	5	2	0	0.0379	0.503	1.000
24	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(5), TPI1(1)	1956213	6	3	6	0	0	3	1	2	0	0	0.133	0.503	1.000
25	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP6(2), ACPP(4), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(3), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), TYR(5)	17839871	35	29	35	4	11	5	7	8	4	0	0.0149	0.532	1.000
26	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(1), TAT(3)	3119700	6	5	5	1	3	1	1	1	0	0	0.366	0.534	1.000
27	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(5), GOT1(2), GOT2(1), TAT(3), TYR(5)	5582938	16	12	15	3	8	1	3	4	0	0	0.216	0.555	1.000
28	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(3), CASP8(2), CFL1(1), CFLAR(1)	4596535	7	6	7	0	0	1	1	2	3	0	0.194	0.576	1.000
29	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(9), PDXK(1), PSAT1(4)	5756041	14	11	12	4	7	5	0	2	0	0	0.257	0.665	1.000
30	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPP(7), ALPPL2(6), DHFR(1), FPGS(2), GGH(1), SPR(1)	7761312	20	18	18	5	10	3	4	1	2	0	0.152	0.668	1.000
31	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), BCKDK(3), CBS(5), CTH(2), MUT(2)	5829980	14	8	14	1	3	5	1	4	1	0	0.0414	0.673	1.000
32	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD58(2), CD8A(1), IL3(2), IL6(2), KITLG(3)	7347641	18	13	18	3	3	2	2	8	3	0	0.143	0.702	1.000
33	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CDO1(1), CSAD(1), GAD1(3), GAD2(1), GGT1(3)	6836871	10	8	10	0	2	4	2	2	0	0	0.0224	0.711	1.000
34	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(2), NR3C1(3), PPARG(3), RETN(1), RXRA(4), TNF(1)	6893647	16	15	16	5	4	4	1	5	2	0	0.375	0.756	1.000
35	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(2), CAT(3), GH1(2), GHR(4), IGF1(3), IGF1R(10), SHC1(1), SOD2(1)	11324958	26	20	26	4	4	5	5	8	4	0	0.0411	0.777	1.000
36	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(5), ALDOA(1), ALDOB(2), TPI1(1)	4641983	9	5	9	1	0	4	1	3	1	0	0.204	0.778	1.000
37	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(2), PLCB1(4), PLCG1(12), PRKCA(6), VAV1(9)	10750032	33	28	31	9	8	5	4	11	4	1	0.321	0.802	1.000
38	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(2), BCMO1(1), RDH5(1)	4624958	6	6	6	2	2	4	0	0	0	0	0.419	0.820	1.000
39	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNB1(1), HTR2C(4), PLCB1(4), TUB(4)	8492989	16	13	16	4	5	3	0	6	2	0	0.352	0.823	1.000
40	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3E(2), CD3G(1), CD4(2), FYN(2), HLA-DRA(4), HLA-DRB1(1), LCK(1), PTPRC(9), ZAP70(8)	10746799	31	24	31	8	11	5	3	10	2	0	0.234	0.825	1.000
41	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	20	CCNA1(3), CCNB1(2), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), E2F1(1), RBL1(6), TFDP1(1)	16495022	42	31	41	6	7	5	7	13	10	0	0.0243	0.830	1.000
42	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), IL6(2), LDLR(3), LPL(2)	6327852	8	8	8	2	0	1	0	7	0	0	0.620	0.833	1.000
43	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(3), ATM(12), BAX(1), BCL2(3), CCND1(4), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(2), E2F1(1), MDM2(5), TIMP3(2)	18486757	37	26	37	6	6	4	7	12	8	0	0.111	0.833	1.000
44	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDK7(1), CDKN1A(2), CHEK1(6), NEK1(4), WEE1(2)	8250713	17	15	17	4	5	4	2	4	2	0	0.488	0.840	1.000
45	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS1(2), ALAS2(1), FECH(2), HMBS(1), PPOX(2), UROD(1), UROS(1)	9006522	12	9	12	1	2	3	2	4	1	0	0.0953	0.844	1.000
46	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2)	3817233	9	8	8	3	4	1	1	2	1	0	0.490	0.846	1.000
47	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(9), CD38(1), ENPP1(5), ENPP3(2), NADSYN1(5), NMNAT1(1), NMNAT2(1), NNMT(1), NNT(6), NT5C(3), NT5E(3), NT5M(1)	17273748	38	28	36	6	8	12	6	9	3	0	0.0111	0.849	1.000
48	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(4)	3862566	7	7	7	3	2	2	1	1	1	0	0.585	0.857	1.000
49	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(1), FUT8(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3)	9345226	17	16	17	4	6	2	3	3	3	0	0.299	0.861	1.000
50	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYA(1), NFYB(1), SP1(1), SP3(5)	5810988	8	7	8	2	1	1	2	2	2	0	0.574	0.863	1.000
51	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	10	CBL(2), CSF1R(5), EGF(10), MET(13), PRKCA(6), SH3GLB1(3), SH3KBP1(5), SRC(2)	17227778	46	27	46	11	15	4	5	15	6	1	0.135	0.865	1.000
52	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(3), SHMT1(2)	4971666	6	5	6	1	2	2	2	0	0	0	0.240	0.873	1.000
53	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(3), JAK2(5), JAK3(5), MAPK1(4), MAPK3(2), STAT3(3), TYK2(10)	14000308	32	22	32	4	12	2	3	8	6	1	0.0325	0.875	1.000
54	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(3), IL13RA2(1), IL4R(9), JAK1(3), JAK2(5), TYK2(10)	12457734	31	24	31	5	11	1	3	10	6	0	0.0655	0.876	1.000
55	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(3), IL13RA2(1), IL4R(9), JAK1(3), JAK2(5), TYK2(10)	12457734	31	24	31	5	11	1	3	10	6	0	0.0655	0.876	1.000
56	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(3), IFNB1(2), JAK1(3), STAT1(4), STAT2(2), TYK2(10)	12879901	26	19	26	4	7	2	2	10	4	1	0.0896	0.877	1.000
57	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(5), PARK2(2), SNCA(1), SNCAIP(1), UBE2G2(1), UBE2L6(1)	7637986	11	11	11	3	7	1	0	2	1	0	0.294	0.879	1.000
58	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	7	GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), GPX1(1), PRKCE(1)	7150368	23	22	23	8	4	5	5	7	2	0	0.484	0.889	1.000
59	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), ME1(2), PC(4), PDHA1(6), SLC25A1(1), SLC25A11(1)	10999700	18	17	16	4	2	4	0	7	5	0	0.258	0.896	1.000
60	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3)	12027388	26	17	26	4	6	4	4	9	3	0	0.0743	0.897	1.000
61	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(2), GPI(2), HK1(4), PFKL(5), PGK1(3), PKLR(4), TPI1(1)	11011208	23	16	23	3	9	7	0	3	4	0	0.00812	0.904	1.000
62	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(3)	3666216	5	3	5	2	1	1	0	2	1	0	0.649	0.912	1.000
63	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(2), BFAR(1), CREB1(2), CREB3(3), MAPK1(4), RAF1(2), SNX13(1), SRC(2), TERF2IP(1)	11548290	18	15	18	3	1	2	5	4	6	0	0.181	0.913	1.000
64	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(7), LPO(5), MPO(4), PRDX1(1), TPO(10), TYR(5)	11481609	32	22	32	7	15	7	2	6	1	1	0.0438	0.913	1.000
65	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(12), CDC25A(1), CDC25B(1), CHEK1(6), MYT1(7), WEE1(2), YWHAH(2)	16361101	31	22	31	6	4	2	5	7	13	0	0.376	0.914	1.000
66	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS1(2), ALAS2(1), CPO(3), FECH(2), GATA1(1), HBA2(1), HBB(1), HMBS(1), UROD(1), UROS(1)	9374306	16	12	16	3	4	3	2	6	1	0	0.164	0.919	1.000
67	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	7	ACO1(6), ACO2(4), FH(1), SUCLA2(1)	8619144	12	8	12	0	3	3	2	3	1	0	0.0186	0.921	1.000
68	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(13), DFFA(2), GZMA(1), GZMB(3), HMGB2(1), PRF1(3), SET(1)	12572264	26	18	26	4	9	2	4	5	6	0	0.0687	0.923	1.000
69	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(1), IFNGR2(4), JAK1(3), JAK2(5), STAT1(4)	9717927	19	14	19	4	1	0	4	8	5	1	0.339	0.924	1.000
70	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	9	ACLY(4), ACO1(6), ACO2(4), ACSS1(1), ACSS2(4), FH(1), SUCLA2(1)	13833875	21	13	21	1	6	5	2	4	4	0	0.00375	0.932	1.000
71	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(2), BCAR1(3), CDKN1B(4), ILK(1), ITGB1(3), MAPK1(4), MAPK3(2), PTK2(2), SHC1(1), SOS1(7)	17510271	29	21	29	3	6	3	6	7	6	1	0.0259	0.932	1.000
72	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(2), NR1I3(1), PTGS1(3), PTGS2(3)	6332472	13	12	13	4	5	2	0	3	3	0	0.510	0.935	1.000
73	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(4), GAD1(3), HDC(5), TH(3), TPH1(5)	7173404	20	15	19	6	11	4	0	4	1	0	0.186	0.937	1.000
74	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), NFS1(3), THTPA(2)	7608183	16	9	16	4	3	3	3	5	2	0	0.470	0.937	1.000
75	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	11	ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(1), PAK1(3), RAC1(1), WASL(2)	8748423	14	8	13	3	0	2	0	6	6	0	0.543	0.939	1.000
76	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(8), GLS(3), GLUD1(4), GOT1(2)	9251054	19	12	19	4	4	1	2	7	5	0	0.425	0.940	1.000
77	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	5	SP1(1), SP3(5), WT1(3)	6727322	9	7	9	2	2	2	1	2	2	0	0.396	0.940	1.000
78	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(7), PCYT1A(2), PDHA1(6), PDHA2(7), SLC18A3(1)	8291589	25	20	23	9	7	8	2	3	5	0	0.263	0.946	1.000
79	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(2), EIF2S2(2), EIF2S3(2), EIF4E(2), GSK3B(1), IGF1(3), IGF1R(10), INPPL1(8), PPP2CA(4), RPS6KB1(2)	17933341	36	25	36	6	6	4	7	12	7	0	0.0674	0.947	1.000
80	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(3), ELK1(5), FOS(2), MAP2K1(1), MAPK3(2), MAPK8(2), NGFR(1), PLCG1(12), RAF1(2), SHC1(1), SOS1(7)	18229725	38	31	36	7	6	9	5	10	7	1	0.0416	0.950	1.000
81	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), CKM(3), EIF4E(2), FBL(2), LDHA(1), LDHB(2), LDHC(1), NCL(3)	10599502	19	13	19	5	5	4	2	4	4	0	0.335	0.958	1.000
82	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(6), DPYS(5), ENPP1(5), ENPP3(2), PANK2(1), PANK4(3)	16531564	25	20	24	5	4	5	0	11	5	0	0.319	0.959	1.000
83	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(2), GOT1(2), GOT2(1), LDHA(1), LDHB(2), LDHC(1)	8119109	9	6	9	1	1	5	0	3	0	0	0.163	0.960	1.000
84	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), OXCT1(1)	4012273	2	2	2	0	0	1	0	1	0	0	0.592	0.961	1.000
85	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(12), CDC25A(1), CDC25B(1), CDK2(1), CDK4(1), CHEK1(6), MYT1(7), WEE1(2), YWHAH(2)	17836994	33	22	33	6	5	2	6	7	13	0	0.291	0.961	1.000
86	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1), AASS(1), KARS(2)	5609809	5	5	5	2	2	0	0	2	1	0	0.767	0.963	1.000
87	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), CD86(3), HLA-DRA(4), HLA-DRB1(1), IFNG(2), IFNGR1(1), IFNGR2(4), IL12B(4), IL12RB1(4), IL12RB2(4), IL18(3), IL18R1(4), IL4R(9)	15050265	45	37	44	14	15	2	5	16	7	0	0.299	0.964	1.000
88	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF2(2), EPO(2), FLT3(8), IGF1(3), IL1A(1), IL3(2), IL6(2), IL9(1), KITLG(3), TGFB2(2), TGFB3(1)	9796105	28	21	28	9	5	5	5	10	3	0	0.433	0.964	1.000
89	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADM(2), ACADS(5), ECHS1(3), HADHA(3)	6418039	14	11	13	5	4	3	2	2	3	0	0.437	0.964	1.000
90	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), NGFR(1), RAF1(2)	9801701	16	12	15	3	3	4	3	1	4	1	0.104	0.964	1.000
91	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAK1(2), BAX(1), BCL2(3), BCL2L11(1), CASP8AP2(1), CASP9(1), CES1(3)	13027583	15	12	15	2	5	2	1	4	3	0	0.173	0.967	1.000
92	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(1), CES1(3)	7173782	8	8	8	2	6	2	0	0	0	0	0.267	0.967	1.000
93	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(2), CYP2A7(1), NAT1(1), NAT2(3), XDH(11)	9455748	22	17	22	6	6	5	1	7	3	0	0.239	0.970	1.000
94	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	14	CD28(2), CD3D(1), CD3E(2), CD3G(1), CD86(3), CTLA4(1), HLA-DRA(4), HLA-DRB1(1), ICOS(1), ITK(1), LCK(1)	9252116	18	15	17	5	6	3	2	4	3	0	0.381	0.971	1.000
95	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(9), CD44(6), FCGR3A(1), IL1B(3), IL6R(1), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF8(4), TNFSF8(3)	15663743	35	27	34	8	13	7	3	5	7	0	0.0423	0.971	1.000
96	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(7), GBA(1), LPO(5), MPO(4), TPO(10)	9953096	27	20	27	8	15	7	1	3	1	0	0.150	0.973	1.000
97	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(2), NTRK1(4), PLCG1(12), PRKCA(6), SHC1(1), SOS1(7)	14001826	32	27	30	8	6	5	5	9	6	1	0.199	0.975	1.000
98	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(4), HK2(5), HK3(5), PGM1(1), PGM3(1), TGDS(2)	12133883	20	15	20	3	10	5	2	2	1	0	0.0328	0.976	1.000
99	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(2), FOS(2), MAPK1(4), MAPK8(2), NFE2L2(1), PRKCA(6)	10546092	17	13	17	4	3	3	4	2	4	1	0.178	0.979	1.000
100	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), GLS(3), GLUD1(4), OAT(1), PRODH(1)	6560824	11	8	11	4	3	1	0	5	2	0	0.651	0.979	1.000
101	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(2), DPYD(6), DPYS(5), ENPP1(5), ENPP3(2), ILVBL(5), PANK2(1), PANK4(3), VNN1(2)	20514867	32	25	31	6	6	6	1	13	6	0	0.176	0.980	1.000
102	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(3), ECHS1(3), EHHADH(2), HADHA(3), SDS(1)	5735428	12	9	12	7	3	3	2	1	3	0	0.746	0.981	1.000
103	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(4), GNB1(1), PRKAR1A(2)	7851446	12	12	12	3	6	1	0	3	2	0	0.432	0.983	1.000
104	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	4	BGN(3), DCN(3), FMOD(1), KERA(4)	3487648	11	11	11	7	1	2	3	4	1	0	0.883	0.984	1.000
105	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(3), BAK1(2), BAX(1), BCL2(3), BIRC2(3), BIRC3(1), CASP8(2), CASP9(1), CYCS(2), DFFA(2), DIABLO(2)	15941883	22	16	22	5	5	4	3	7	3	0	0.292	0.984	1.000
106	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(1), BDH2(1), HMGCS1(2), HMGCS2(3), OXCT1(1), OXCT2(1)	8521839	10	5	10	1	2	3	0	4	1	0	0.188	0.984	1.000
107	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(2), IGF1R(10), IRS1(8), MAP2K1(1), MAPK1(4), MAPK3(2), RAF1(2), SHC1(1), SOS1(7), YWHAH(2)	18023717	39	33	39	9	7	6	8	7	10	1	0.123	0.985	1.000
108	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CEBPB(2), CSNK2A1(3), ELK1(5), FOS(2), IL6(2), IL6R(1), IL6ST(3), JAK1(3), JAK2(5), JAK3(5), MAP2K1(1), MAPK3(2), RAF1(2), SHC1(1), SOS1(7), SRF(3), STAT3(3)	26981649	50	38	50	7	11	10	3	15	10	1	0.00823	0.985	1.000
109	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(2), PPP1R1B(1)	4492415	5	4	5	2	3	0	0	2	0	0	0.588	0.986	1.000
110	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(5), ARHGDIB(1), CASP1(8), CASP10(2), CASP8(2), CASP9(1), CYCS(2), GZMB(3), PRF1(3)	15283399	30	24	29	9	6	7	3	12	2	0	0.382	0.987	1.000
111	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(2), ENO3(2), FARS2(3), GOT1(2), GOT2(1), PAH(4), TAT(3), YARS(1)	9843109	20	13	19	4	10	4	1	3	2	0	0.162	0.987	1.000
112	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(2), RAB3A(1), RAB9A(1)	5054138	4	3	4	1	2	1	0	1	0	0	0.573	0.987	1.000
113	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(1), GGT1(3), SHMT1(2)	6582337	6	6	6	2	2	2	2	0	0	0	0.457	0.988	1.000
114	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(5), NRG2(1), PRKCA(6), PSEN1(1)	10694245	13	9	13	2	4	1	2	4	1	1	0.203	0.988	1.000
115	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(2), CHAT(7), DBH(4), DDC(5), GAD1(3), GAD2(1), HDC(5), MAOA(3), PAH(4), SLC18A3(1), TH(3), TPH1(5)	17106931	45	33	44	13	21	9	2	10	3	0	0.0787	0.989	1.000
116	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(1), CDC25B(1), CSK(2), PRKCA(6), PTPRA(7), SRC(2)	10931833	21	14	21	4	9	5	3	3	0	1	0.0768	0.989	1.000
117	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL15(2), IL16(9), IL18(3), IL1A(1), IL3(2), IL5(1), IL6(2), IL9(1), TNF(1)	11770120	31	24	31	10	5	4	5	12	5	0	0.453	0.990	1.000
118	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), ANKRD1(1), CYR61(1), DUSP14(1), EIF4E(2), HBEGF(1), IFNG(2), IFRD1(3), IL18(3), IL1A(1), IL1R1(4), NR4A3(1), WDR1(3)	12822925	27	23	27	9	5	4	3	6	9	0	0.641	0.990	1.000
119	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(3), BIRC3(1), CASP10(2), CASP8(2), CASP9(1), DFFA(2), GZMB(3), PRF1(3), SCAP(3), SREBF1(7), SREBF2(4)	21732665	34	27	34	7	11	7	6	8	2	0	0.0772	0.990	1.000
120	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP54(2), SRP68(2), SRP72(3), SRPR(7)	8951311	15	10	15	3	5	1	3	3	3	0	0.313	0.990	1.000
121	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(9), ACE2(7), AGT(3), AGTR1(1), AGTR2(4), ANPEP(5), CMA1(3), CTSA(1), CTSG(5), ENPEP(10), LNPEP(3), MME(3), NLN(1), THOP1(5)	24181728	60	45	58	14	21	10	7	14	8	0	0.0291	0.991	1.000
122	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT2(2), FUT3(2), FUT5(6), FUT6(3), ST3GAL3(2)	6053179	16	13	16	6	10	1	0	4	1	0	0.547	0.991	1.000
123	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	17	CSNK2A1(3), ELK1(5), FOS(2), IGF1(3), IGF1R(10), IRS1(8), MAP2K1(1), MAPK3(2), MAPK8(2), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3)	23532436	53	44	53	13	11	10	8	11	12	1	0.0978	0.991	1.000
124	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(4), HK2(5), HK3(5), ISYNA1(2), PGM1(1), PGM3(1), TGDS(2)	13862482	22	16	22	3	10	6	2	3	1	0	0.0171	0.991	1.000
125	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(3), MBTPS1(2), MBTPS2(3), SCAP(3), SREBF1(7), SREBF2(4)	14266597	24	18	24	6	5	5	3	8	3	0	0.233	0.992	1.000
126	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PCYT1A(2), PCYT1B(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), WBSCR22(3)	16725887	31	19	31	7	8	4	5	8	6	0	0.147	0.992	1.000
127	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(2), GFPT1(5), GNPDA1(3), HEXA(1), HEXB(1), HK1(4), HK2(5), HK3(5), PGM3(1), RENBP(4), UAP1(2)	20112258	35	26	35	5	12	7	5	7	4	0	0.0175	0.992	1.000
128	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(2), CASP9(1), CHUK(1), GH1(2), GHR(4), NFKB1(2), NFKBIA(3), PPP2CA(4), RELA(1), YWHAH(2)	12253676	22	15	22	6	4	5	2	8	3	0	0.339	0.993	1.000
129	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), ATP6V0C(1), CAT(3), EPX(7), LPO(5), MPO(4), PRDX1(1), SHMT1(2), TPO(10)	14045390	34	20	34	9	16	9	2	4	2	1	0.0622	0.993	1.000
130	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), FHL5(3), FSHR(3), GNAS(4), XPO1(1)	11387888	16	15	16	4	5	3	3	3	2	0	0.390	0.993	1.000
131	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(5), CTH(2), GGT1(3), MARS(7), MARS2(2), MAT1A(2), SCLY(3), SEPHS1(1)	14692219	25	16	25	4	5	8	3	6	3	0	0.0481	0.993	1.000
132	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(3), EPX(7), LPO(5), MPO(4), MTHFR(7), SHMT1(2), TPO(10)	13795631	39	22	39	9	17	9	4	6	3	0	0.0384	0.993	1.000
133	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(2), F2(4), F2R(2), F5(13), F7(2), FGA(12), FGB(4), FGG(6), PROS1(3), SERPINC1(2)	19445524	50	45	49	14	15	7	10	13	5	0	0.150	0.993	1.000
134	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADM(2), ACADS(5), ACADVL(3), ACSL1(4), ACSL3(3), ACSL4(6), CPT1A(2), CPT2(2), EHHADH(2), HADHA(3), PECR(2), SCP2(1), SLC25A20(1)	19965837	37	25	36	9	6	8	4	8	11	0	0.136	0.994	1.000
135	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(15), MAP2(9), PPP1CA(1), PPP2CA(4), PRKACG(1), PRKAG1(1), PRKAR2B(1), PRKCE(1)	21589195	33	19	33	4	5	5	4	10	9	0	0.0785	0.994	1.000
136	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(4), PRKCA(6), TGM2(1)	5890694	13	10	13	5	5	0	1	6	0	1	0.585	0.995	1.000
137	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), WBSCR22(3)	17834744	32	18	31	8	10	4	6	7	5	0	0.157	0.995	1.000
138	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(17), CPT1A(2), LEPR(3), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(2)	17181944	30	18	30	4	10	3	1	9	7	0	0.0540	0.995	1.000
139	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	7	ACE(9), AGT(3), AGTR1(1), AGTR2(4), KNG1(4), NOS3(10)	10833993	31	26	30	10	17	4	2	5	3	0	0.263	0.996	1.000
140	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL10(1)	4722277	10	8	9	5	4	1	1	3	1	0	0.686	0.996	1.000
141	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(4), FDFT1(1), FDPS(3), HMGCS1(2), IDI1(2), LSS(1), MVD(4), MVK(1), NSDHL(2), SQLE(1)	15693512	23	15	23	6	8	1	5	6	3	0	0.344	0.996	1.000
142	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(4), FDFT1(1), FDPS(3), IDI1(2), LSS(1), MVD(4), MVK(1), NQO1(2), NQO2(1), SQLE(1)	13172587	20	13	20	5	6	1	5	4	4	0	0.343	0.996	1.000
143	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	18	ACO1(6), ACO2(4), DLD(3), FH(1), IDH3A(1), IDH3B(1), PC(4), PCK1(6), SDHA(4), SUCLA2(1), SUCLG1(2), SUCLG2(1)	22498020	34	27	33	5	8	9	5	9	3	0	0.0163	0.997	1.000
144	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(2), EPO(2), EPOR(1), GRIN1(3), JAK2(5), NFKB1(2), NFKBIA(3), RELA(1), SOD2(1)	15051554	21	15	21	5	6	2	2	8	3	0	0.290	0.997	1.000
145	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(1), CDC25B(1), CDK7(1), SHH(3), XPO1(1)	10326589	11	8	11	3	5	5	1	0	0	0	0.281	0.997	1.000
146	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(2), IL6R(1), JAK1(3), JAK2(5), JAK3(5), PIAS3(3), PTPRU(3), REG1A(2), SRC(2), STAT3(3)	18144077	30	25	30	7	7	4	2	10	7	0	0.201	0.997	1.000
147	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(1), RAC1(1), WASF1(1), WASL(2)	9651747	12	6	12	3	0	2	1	6	3	0	0.525	0.997	1.000
148	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), LCT(13), MPI(1), PGM1(1), PYGL(6), PYGM(2), TPI1(1), TREH(2)	15928923	30	20	30	7	8	6	5	5	6	0	0.0761	0.997	1.000
149	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(10), ERBB3(4), NRG1(5)	9086686	19	15	19	6	7	2	0	5	5	0	0.590	0.998	1.000
150	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP6(2), ACPP(4), ACPT(2), ALPI(2), ALPP(7), ALPPL2(6), CYP3A4(5), CYP3A43(1), CYP3A7(6), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), PON1(4), PON3(1)	21370075	46	41	43	12	24	3	5	8	6	0	0.0918	0.998	1.000
151	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	19	AKT1(2), CCND1(4), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(2), CDKN1B(4), E2F1(1), MAPK1(4), MAPK3(2), NFKB1(2), NFKBIA(3), PAK1(3), RAC1(1), RAF1(2), RELA(1), TFDP1(1)	17460162	36	26	35	7	8	4	7	6	10	1	0.0712	0.998	1.000
152	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(5), AKT1(2), BAX(1), BCL2(3), CSF2RB(6), IGF1(3), IGF1R(10), IL3(2), IL3RA(4), KIT(9), KITLG(3), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), YWHAH(2)	21574168	55	42	54	12	17	4	9	15	10	0	0.0525	0.998	1.000
153	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(3), MST1(8), MST1R(4), TNF(1)	7789225	17	12	16	6	5	6	1	3	2	0	0.426	0.998	1.000
154	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(4), F2R(2), F2RL3(3), GNAI1(4), GNB1(1), ITGA1(4), ITGB1(3), MAP2K1(1), MAPK1(4), MAPK3(2), PLA2G4A(7), PLCB1(4), PRKCA(6), PTGS1(3), PTK2(2), RAF1(2), SRC(2), TBXAS1(2)	28959295	56	44	56	11	13	4	11	20	6	2	0.0460	0.998	1.000
155	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3D(1), CD3E(2), CD3G(1), IFNG(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TGFBR3(3), TOB1(1), TOB2(1)	12550187	25	18	24	6	6	7	4	5	3	0	0.119	0.999	1.000
156	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(7), CYP11B2(3), HSD11B1(2), HSD3B1(2), HSD3B2(1)	8188994	17	17	17	7	9	3	1	1	3	0	0.450	0.999	1.000
157	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(2), JAK1(3), PTPRU(3), REG1A(2), STAT1(4), STAT2(2), TYK2(10)	14845481	28	21	28	8	8	1	2	9	7	1	0.342	0.999	1.000
158	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB8(3)	10360020	16	9	16	3	4	5	3	3	1	0	0.184	0.999	1.000
159	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(9), BST1(1), CD38(1), ENPP1(5), ENPP3(2), NADK(1), NADSYN1(5), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(1), NNT(6), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(3), NT5M(1), NUDT12(1)	25558214	49	34	47	13	11	15	7	11	5	0	0.0926	0.999	1.000
160	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6)	9496019	20	14	20	7	10	3	2	3	2	0	0.359	0.999	1.000
161	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6)	9496019	20	14	20	7	10	3	2	3	2	0	0.359	0.999	1.000
162	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(1), CASP8(2), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2)	9991431	16	15	16	6	5	3	2	3	3	0	0.557	0.999	1.000
163	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), CYCS(2), GPD2(1), SDHA(4), SDHC(2), UQCRC1(4)	7844250	14	10	13	5	2	3	5	4	0	0	0.498	0.999	1.000
164	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CDO1(1), CTH(2), GOT1(2), GOT2(1), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), SDS(1), SULT1B1(9), SULT1C2(3)	14877425	26	18	26	7	3	8	2	10	3	0	0.350	0.999	1.000
165	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(2), IFNGR1(1), JAK1(3), JAK2(5), PTPRU(3), REG1A(2), STAT1(4)	13576306	21	15	21	7	3	1	2	7	7	1	0.502	0.999	1.000
166	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), ARHGDIB(1), BIRC2(3), BIRC3(1), CASP1(8), CASP10(2), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CYCS(2), DFFA(2), GZMB(3), LMNA(2), LMNB2(3), PRF1(3)	22953722	38	27	38	9	9	9	6	11	3	0	0.143	0.999	1.000
167	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(6), ACO2(4), AFMID(1), HAO1(4), HAO2(2), HYI(3), MTHFD1(3), MTHFD1L(1)	15880457	24	16	24	5	4	5	4	6	5	0	0.195	0.999	1.000
168	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(3), ECHS1(3), HADHA(3), HSD17B4(3), MECR(2), PPT2(1)	10070357	15	12	15	6	2	3	2	4	4	0	0.675	0.999	1.000
169	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(1), AKT1(2), ANXA1(2), CALM1(1), CALM3(1), GNAS(4), GNB1(1), NFKB1(2), NOS3(10), NPPA(2), NR3C1(3), RELA(1), SYT1(2)	16870011	32	25	32	9	14	4	4	7	3	0	0.327	0.999	1.000
170	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), ST6GALNAC4(1), ST8SIA1(2)	6701819	10	10	10	5	4	0	1	3	2	0	0.839	0.999	1.000
171	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(6), ATM(12), ATR(10), CCNA1(3), CCND1(4), CCNE1(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), DHFR(1), E2F1(1), GSK3B(1), SKP2(4), TFDP1(1), TGFB2(2), TGFB3(1)	32720599	65	43	64	9	11	9	11	19	15	0	0.00506	0.999	1.000
172	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), FUT2(2), GCNT2(2), ST8SIA1(2)	7299839	7	5	7	6	3	1	0	1	2	0	0.980	0.999	1.000
173	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	DLL1(1), FURIN(1), PSEN1(1)	6197024	3	3	3	2	1	0	0	1	1	0	0.948	0.999	1.000
174	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(2), CP(7), EPRS(5), FECH(2), GUSB(3), HCCS(5), HMBS(1), HMOX1(1), PPOX(2), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(3), UGT2B4(9), UROD(1), UROS(1)	32493976	67	52	66	15	18	9	13	23	4	0	0.0372	0.999	1.000
175	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(3), AASDHPPT(1), AASS(1), KARS(2)	8268664	8	7	8	4	2	0	1	3	2	0	0.880	0.999	1.000
176	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), MIOX(1), UGDH(1)	10137379	20	12	20	5	11	2	2	3	2	0	0.184	0.999	1.000
177	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CD8A(1), CSF2(2), EPO(2), IL3(2), IL5(1), IL6(2), IL7(1), IL9(1)	7211957	14	12	14	7	4	2	1	5	2	0	0.776	0.999	1.000
178	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), SULT1A2(1), SULT2A1(2), SUOX(2)	7241287	6	3	6	5	0	1	0	4	1	0	0.970	0.999	1.000
179	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	19	F10(2), F12(1), F13B(5), F2(4), F5(13), F7(2), F8(24), FGA(12), FGB(4), FGG(6), LPA(11), PLAT(3), PLAU(1), PLG(6), SERPINB2(3), SERPINE1(4), SERPINF2(1), VWF(14)	40774477	116	81	115	29	32	21	15	30	18	0	0.0116	0.999	1.000
180	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2)	6687477	16	10	16	8	3	1	1	11	0	0	0.854	0.999	1.000
181	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(6), ACO2(4), HAO1(4), HAO2(2), HYI(3), MTHFD1(3), MTHFD1L(1)	15162449	23	15	23	5	4	5	4	6	4	0	0.199	0.999	1.000
182	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), CHPF(1), CHST11(3), CHST13(3), CHST3(3), CHSY1(4), DSE(6), UST(1), XYLT1(3), XYLT2(3)	16680196	28	23	28	6	10	4	2	8	4	0	0.0818	0.999	1.000
183	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(7), CYP11B1(3), CYP11B2(3), CYP21A2(2), HSD11B1(2), HSD3B1(2), HSD3B2(1)	11007722	23	22	23	8	9	3	2	4	5	0	0.452	0.999	1.000
184	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(7), CYP11B1(3), CYP11B2(3), CYP21A2(2), HSD11B1(2), HSD3B1(2), HSD3B2(1)	11007722	23	22	23	8	9	3	2	4	5	0	0.452	0.999	1.000
185	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(13), EP300(6), ESR1(3), MAPK1(4), MAPK3(2), PELP1(2), SRC(2)	17522973	32	21	31	7	10	5	4	7	5	1	0.118	0.999	1.000
186	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(17), ACACB(18), FASN(3), MCAT(4), OXSM(3)	18824614	45	35	45	13	15	8	5	10	7	0	0.165	0.999	1.000
187	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(4), RECK(4), TIMP1(1), TIMP3(2), TIMP4(2)	8936183	13	10	13	5	5	2	1	3	2	0	0.575	0.999	1.000
188	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	ATG12(2), ATG5(4), ATG7(3), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNG(2), PIK3C3(2), PIK3R4(3), PRKAA1(3), PRKAA2(2), ULK1(2), ULK2(7)	24599447	36	19	35	5	7	4	7	9	9	0	0.0192	1.000	1.000
189	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	12	AKT1(2), BCL2(3), IGF1R(10), POLR2A(9), PPP2CA(4), PRKCA(6), TEP1(12), TERF1(1), TERT(5), TNKS(2), XRCC5(4)	27288018	58	41	58	13	20	6	9	15	7	1	0.0355	1.000	1.000
190	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ACYP1(1), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), SDS(1)	9252577	12	10	12	9	2	4	1	2	3	0	0.926	1.000	1.000
191	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(6), FOS(2), IL3(2), IL3RA(4), JAK2(5), MAP2K1(1), MAPK3(2), PTPN6(1), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2)	20999106	36	27	35	9	10	3	5	11	6	1	0.221	1.000	1.000
192	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(6), CDKN2A(6), E2F1(1), MDM2(5), POLR1A(7), POLR1B(3), RAC1(1), TBX2(1)	16501409	30	18	29	8	7	3	4	7	9	0	0.185	1.000	1.000
193	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), AGPS(3), ENPP2(8), ENPP6(2), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLD1(8), PPAP2A(2), PPAP2C(1)	27531374	57	39	56	14	17	8	8	19	5	0	0.0984	1.000	1.000
194	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(4), NDUFA4(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), NDUFV2(1)	8275691	12	7	12	5	0	1	2	5	4	0	0.818	1.000	1.000
195	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(12), ATR(10), CHEK1(6), CHEK2(3), YWHAH(2)	18038138	33	22	33	7	5	6	7	8	7	0	0.261	1.000	1.000
196	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(3), ECHS1(3), EHHADH(2), HADHA(3), HSD17B4(3), SIRT1(1), SIRT2(1), SIRT5(3), SIRT7(1), VNN2(1)	14062823	21	17	21	9	5	3	2	5	6	0	0.715	1.000	1.000
197	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(4), GNB1(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6)	11433929	18	15	18	5	8	0	1	7	1	1	0.577	1.000	1.000
198	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(2), B3GALT2(1), B3GALT5(2), B3GNT5(4), FUT2(2), FUT3(2), ST3GAL3(2), ST3GAL4(3)	8560651	19	14	19	7	10	0	1	6	2	0	0.564	1.000	1.000
199	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	ARFIP2(2), CFL1(1), LIMK1(4), MAP3K1(9), MYL2(2), MYLK(7), NCF2(5), PAK1(3), PLD1(8), PPP1R12B(1), RAC1(1), RALBP1(3), RPS6KB1(2), TRIO(7), VAV1(9), WASF1(1)	34326266	65	46	62	13	17	9	12	15	12	0	0.0133	1.000	1.000
200	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), NFKBIA(3), PLCB1(4), PRKCA(6), RELA(1)	9782185	16	13	16	8	5	0	1	7	2	1	0.855	1.000	1.000
201	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(2), PTK2B(5), SHC1(1), SOS1(7), SRC(2)	10484569	17	15	17	5	3	3	1	6	4	0	0.411	1.000	1.000
202	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(5), ADRB2(1), GNAS(4), PLCE1(10), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RAP2B(4)	17565426	29	24	29	7	13	6	2	4	4	0	0.163	1.000	1.000
203	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), ADRB2(1), CFTR(6), GNAS(4), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), SLC9A3R1(1)	15569044	22	20	22	5	11	3	1	5	2	0	0.224	1.000	1.000
204	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(1), FUCA1(6), FUCA2(4), GLB1(2), HEXA(1), HEXB(1), LCT(13), MAN2C1(2), MANBA(1), NEU1(2), NEU3(2), NEU4(2)	18761673	37	29	37	10	10	6	7	10	4	0	0.247	1.000	1.000
205	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM3(1), CDKN1A(2), MARCKS(1), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKCA(6), SP1(1), SP3(5), SYT1(2)	24908800	51	38	49	13	13	8	7	14	8	1	0.100	1.000	1.000
206	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	19	ADCY1(5), AKT1(2), ASAH1(2), GNAI1(4), GNB1(1), ITGAV(3), ITGB3(4), MAPK1(4), MAPK3(2), PDGFA(1), PLCB1(4), PRKCA(6), PTK2(2), RAC1(1), SMPD1(1), SMPD2(1), SRC(2)	25453829	45	34	45	11	12	6	10	9	6	2	0.0753	1.000	1.000
207	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1A(1), BMPR1B(1), BMPR2(1)	7460567	6	5	6	6	2	0	2	1	1	0	0.991	1.000	1.000
208	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(3), ATM(12), BAX(1), BCL2(3), CASP9(1), CYCS(2), PRKCA(6), PTK2(2), PXN(1), STAT1(4), TLN1(5)	31578944	42	29	42	8	7	3	6	16	8	2	0.140	1.000	1.000
209	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(5), HSD17B3(1), HSD17B4(3), HSD17B7(2), HSD3B1(2), HSD3B2(1)	9608865	14	14	13	8	2	5	3	2	2	0	0.787	1.000	1.000
210	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(3), ADRB2(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), DRD1(1), DRD2(1), DRD3(3), HRH1(3), HRH2(3), HTR1A(2), HTR1B(2), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4)	29416649	73	56	71	19	38	13	6	10	6	0	0.00199	1.000	1.000
211	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(1), PSMC3(2), PSMD1(1), PSMD11(2), PSMD2(3)	18984499	22	12	22	4	3	9	3	4	3	0	0.129	1.000	1.000
212	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(3), ELK1(5), FOS(2), JAK1(3), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), PDGFA(1), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(4), STAT3(3), STAT5A(1)	34343615	71	55	67	15	16	16	8	17	11	3	0.0188	1.000	1.000
213	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ARG2(2), ASL(2), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), GAMT(1), GATM(2), GLUD1(4), NAGS(1), OAT(1), ODC1(3), OTC(2), SMS(2)	20822996	39	27	39	9	10	6	4	11	8	0	0.184	1.000	1.000
214	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(3), FARSA(1), GOT1(2), GOT2(1), PAH(4), TAT(3), YARS(1), YARS2(1)	10343210	16	13	15	5	6	5	1	3	1	0	0.431	1.000	1.000
215	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(2), CMAS(2), CYB5R1(1), GFPT1(5), GFPT2(3), GNPDA1(3), GNPNAT1(2), HEXA(1), HEXB(1), HK1(4), HK2(5), HK3(5), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), NANS(1), NPL(1), PGM3(1), RENBP(4), UAP1(2)	34057697	56	42	56	12	16	10	10	12	8	0	0.0545	1.000	1.000
216	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(3), EGF(10), ELK1(5), FOS(2), JAK1(3), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(4), STAT3(3), STAT5A(1)	36914684	80	62	76	20	19	17	8	21	12	3	0.0680	1.000	1.000
217	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(13), DAXX(5), PAX3(4), PML(3), SIRT1(1), SP100(6), TNF(1), TNFRSF1A(1), TNFRSF1B(3)	19605087	37	24	37	9	8	6	4	12	7	0	0.202	1.000	1.000
218	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	17885914	24	20	24	7	7	7	4	5	0	1	0.242	1.000	1.000
219	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	17885914	24	20	24	7	7	7	4	5	0	1	0.242	1.000	1.000
220	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	17885914	24	20	24	7	7	7	4	5	0	1	0.242	1.000	1.000
221	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(3), FOS(2), JAK2(5), MAP2K1(1), MAPK3(2), MPL(5), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), STAT1(4), STAT3(3), STAT5A(1), STAT5B(2), THPO(2)	31097442	62	47	60	12	15	9	7	18	10	3	0.0246	1.000	1.000
222	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(8), EPHB1(4), FYN(2), ITGA1(4), ITGB1(3), L1CAM(12), LYN(2), SELP(4)	18735937	39	27	39	12	13	7	8	10	1	0	0.257	1.000	1.000
223	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), FOS(2), MAPK3(2), OPRK1(2), POLR2A(9), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1)	15314843	22	19	22	7	7	2	2	7	3	1	0.457	1.000	1.000
224	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(17), ACACB(18), ACADM(2), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ALDH7A1(2), ECHS1(3), EHHADH(2), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), MLYCD(4), MUT(2), PCCA(3), PCCB(4), SUCLA2(1), SUCLG1(2), SUCLG2(1)	47091000	101	65	101	21	33	23	8	24	13	0	0.00410	1.000	1.000
225	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(13), EP300(6), LPL(2), NCOA1(3), NCOA2(5), PPARG(3), RXRA(4)	21938268	36	27	35	10	9	7	2	11	7	0	0.307	1.000	1.000
226	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(15), ABCB11(3), ABCB4(12), ABCC1(6), ABCC3(6)	17031636	42	31	41	14	11	7	4	12	7	1	0.348	1.000	1.000
227	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	21	COL4A1(4), COL4A2(7), COL4A3(1), COL4A4(11), COL4A5(11), COL4A6(9), F10(2), F12(1), F2(4), F2R(2), F5(13), F8(24), FGA(12), FGB(4), FGG(6), KLKB1(7), PROS1(3), SERPINC1(2), SERPING1(4)	51751552	127	96	125	30	30	27	21	31	17	1	0.00395	1.000	1.000
228	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(3), GLS2(1), GLUD1(4), GLUD2(4)	5397172	12	11	12	6	3	2	0	6	1	0	0.857	1.000	1.000
229	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(3), ELK1(5), EPO(2), EPOR(1), FOS(2), JAK2(5), MAP2K1(1), MAPK3(2), MAPK8(2), PLCG1(12), PTPN6(1), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2)	25561941	49	38	47	12	9	9	7	15	8	1	0.106	1.000	1.000
230	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(12), ATR(10), BRCA1(6), BRCA2(13), CHEK1(6), CHEK2(3), FANCA(4), FANCC(1), FANCD2(10), FANCE(2), HUS1(1), MRE11A(3), RAD1(2), RAD17(2), RAD50(6), RAD9A(2), TREX1(2)	51437187	85	56	84	15	18	19	17	20	11	0	0.00692	1.000	1.000
231	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), DNAJC3(2), EIF2S2(2), NFKB1(2), NFKBIA(3), RELA(1)	10674982	11	8	11	5	2	2	1	4	2	0	0.731	1.000	1.000
232	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(3), BCL2(3), CASP9(1), CYCS(2), DAXX(5), FAS(1), FASLG(1), IL1A(1), MAPKAPK2(2), MAPKAPK3(2), TNF(1)	13468717	22	14	22	8	1	6	4	8	3	0	0.665	1.000	1.000
233	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), DAG1(3)	7238664	5	5	5	3	1	1	3	0	0	0	0.779	1.000	1.000
234	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(2), GZMB(3), HMGB2(1), TOP2A(4), TOP2B(3)	10729155	13	8	13	5	5	1	2	3	2	0	0.696	1.000	1.000
235	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(9), BAIAP2(3), CASP1(8), CASP8(2), GAPDH(1), INSR(6), ITCH(1), MAGI1(6), MAGI2(6), RERE(11), WWP1(3), WWP2(2)	28480069	58	40	57	14	16	15	5	15	7	0	0.104	1.000	1.000
236	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CAMK4(3), CAMKK1(2), CAMKK2(2), CREB1(2), SYT1(2)	13760218	23	14	23	8	6	5	5	1	6	0	0.384	1.000	1.000
237	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(3), HS3ST3A1(3), XYLT1(3), XYLT2(3)	7840481	12	12	12	5	6	2	3	1	0	0	0.521	1.000	1.000
238	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(3), HS3ST3A1(3), XYLT1(3), XYLT2(3)	7840481	12	12	12	5	6	2	3	1	0	0	0.521	1.000	1.000
239	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(3), CRY1(3), CSNK1E(1), PER1(6)	10144550	13	9	12	6	3	3	1	4	2	0	0.826	1.000	1.000
240	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(1), HDAC9(3), MEF2A(4), MEF2B(1), MEF2D(1), MYOD1(1), YWHAH(2)	9249506	15	11	15	6	2	5	2	2	4	0	0.628	1.000	1.000
241	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(5), GALNT10(1), GALNT2(3), GALNT3(1), GALNT4(1), GALNT6(4), GALNT7(1), GALNT8(1), GALNT9(4), GCNT1(2), ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), WBSCR17(11)	17122631	41	31	41	12	16	7	5	8	5	0	0.247	1.000	1.000
242	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	8	ADAR(4), APOBEC2(1), APOBEC3B(2), APOBEC3C(1), APOBEC3F(5), APOBEC3G(1), APOBEC4(1)	8113179	15	15	15	7	6	3	1	4	1	0	0.716	1.000	1.000
243	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3D(1), CD3E(2), CD3G(1), CD4(2), CREBBP(13), CSK(2), GNAS(4), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTPRC(9), ZAP70(8)	27349378	59	45	59	13	21	9	4	17	8	0	0.0727	1.000	1.000
244	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3D(1), CD3E(2), CD3G(1), CD4(2), CREBBP(13), CSK(2), GNAS(4), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTPRC(9), ZAP70(8)	27349378	59	45	59	13	21	9	4	17	8	0	0.0727	1.000	1.000
245	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(4), PDHA1(6), PDHA2(7), PDHB(1)	11898855	23	18	21	9	3	8	2	5	5	0	0.626	1.000	1.000
246	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(4), CAPN1(2), CAPNS1(2), CAPNS2(1), CSNK1A1(2), CSNK1D(2), GSK3B(1), PPP2CA(4)	11056196	18	10	18	7	4	3	4	6	1	0	0.621	1.000	1.000
247	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(1), CBS(5), CTH(2), GGT1(3), LCMT1(3), LCMT2(2), MARS(7), MARS2(2), MAT1A(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SCLY(3), SEPHS1(1), WBSCR22(3)	29619040	52	31	52	10	11	12	8	13	8	0	0.0198	1.000	1.000
248	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), FDXR(1), SHMT1(2)	19029470	25	20	25	7	8	7	4	5	0	1	0.210	1.000	1.000
249	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(5), FOS(2), FYN(2), THBS1(6)	8769079	15	12	15	7	5	5	3	1	1	0	0.529	1.000	1.000
250	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2)	15756123	35	20	35	13	13	2	3	15	2	0	0.531	1.000	1.000
251	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(3), ACTN2(6), ACTN3(1), BCAR1(3), CSK(2), CTNNA1(2), CTNNA2(5), CTNNB1(3), PTK2(2), PXN(1), SRC(2), VCL(1)	22782479	31	21	31	7	11	6	3	7	4	0	0.159	1.000	1.000
252	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), IFNG(2), IL12B(4), IL12RB1(4), IL12RB2(4), JAK2(5), STAT4(4), TYK2(10)	17509149	41	26	41	10	19	2	6	9	5	0	0.140	1.000	1.000
253	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(3), CHST13(3), SULT1A1(1), SULT1A2(1), SULT2A1(2), SULT2B1(3), SUOX(2)	10919578	16	12	16	6	3	2	0	9	2	0	0.691	1.000	1.000
254	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3D(1), CD3E(2), CD3G(1), ETV5(3), IFNG(2), IL12B(4), IL12RB1(4), IL12RB2(4), IL18(3), IL18R1(4), JAK2(5), MAPK8(2), STAT4(4), TYK2(10)	22197772	50	34	50	15	19	3	10	13	5	0	0.278	1.000	1.000
255	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(2), ALOX5(2), CYP1A2(4), CYP2C18(3), CYP2C19(6), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP3A4(5), CYP3A43(1), CYP3A7(6), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3)	28335289	61	52	61	16	21	8	7	16	9	0	0.126	1.000	1.000
256	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(3), GREB1(7), MTA1(1), MTA3(3), PDZK1(1), TUBA8(2)	13013752	19	12	19	8	8	3	1	4	3	0	0.537	1.000	1.000
257	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	ELK1(5), GNAS(4), GNB1(1), IGF1R(10), ITGB1(3), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MKNK1(2), NGFR(1), PPP2CA(4), PTPRR(6), RAF1(2), RPS6KA1(5), RPS6KA5(2), SHC1(1), SOS1(7), SRC(2), STAT3(3)	33557665	66	51	66	16	19	9	9	17	11	1	0.0896	1.000	1.000
258	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(5), CCNB1(2), GNAI1(4), GNAS(4), GNB1(1), MAPK1(4), MAPK3(2), MYT1(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RPS6KA1(5), SRC(2)	24422777	41	36	41	10	12	3	5	8	12	1	0.245	1.000	1.000
259	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(15), AKT1(2), ATM(12), BAX(1), CDKN1A(2), CPB2(1), CSNK1A1(2), CSNK1D(2), MAPK8(2), MDM2(5), NQO1(2)	23743132	46	35	45	13	11	6	5	14	10	0	0.432	1.000	1.000
260	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(7), ATP4B(2), ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), ATP7A(12), ATP7B(4), COX10(5), COX6B1(1), COX7A1(1), COX7B(3), COX7C(1), NDUFA10(4), NDUFA4(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(1), SDHA(4), SHMT1(2), UQCRC1(4), UQCRH(2)	45362924	83	58	81	15	16	15	15	27	9	1	0.00279	1.000	1.000
261	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(1), PON1(4), PON3(1)	10665323	14	10	13	9	6	0	1	5	2	0	0.961	1.000	1.000
262	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(2), CASP9(1), CHUK(1), ELK1(5), H2AFX(1), MAP2K1(1), MAPK3(2), NFKB1(2), RAC1(1), RAF1(2), RALA(2), RALBP1(3), RALGDS(5), RELA(1)	18225290	29	19	29	9	6	3	4	7	8	1	0.386	1.000	1.000
263	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(3), EGF(10), HGS(3), TF(2), TFRC(2)	12107464	20	15	20	9	6	3	2	7	2	0	0.781	1.000	1.000
264	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM1(1), CALM3(1), CRKL(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), PAK1(3), PLCG1(12), PRKCA(6), PTK2B(5), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SRC(2), SYT1(2)	33878160	73	55	68	16	18	16	12	11	14	2	0.0107	1.000	1.000
265	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), CDKN1A(2), ELK1(5), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CD(3), SHC1(1), SOS1(7)	16671442	27	20	27	9	7	5	2	7	6	0	0.378	1.000	1.000
266	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(17), ACAT2(1), ACYP1(1), ADH5(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), DLD(3), HAGH(1), LDHA(1), LDHB(2), LDHC(1), LDHD(1), ME1(2), ME2(2), ME3(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PKLR(4)	43921933	82	62	80	21	28	20	5	18	11	0	0.0365	1.000	1.000
267	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(2), BCR(3), BLNK(2), ELK1(5), FOS(2), LYN(2), MAP2K1(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8IP3(6), PAPPA(6), RAC1(1), RPS6KA1(5), RPS6KA3(4), SHC1(1), SOS1(7), VAV1(9), VAV2(4), VAV3(3)	38113630	78	54	76	19	18	16	8	22	13	1	0.0428	1.000	1.000
268	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(2), CREB1(2), MAPK1(4), MAPK3(2), MAPK7(6), MEF2A(4), MEF2B(1), MEF2D(1), NTRK1(4), PLCG1(12), RPS6KA1(5), SHC1(1)	18035138	44	34	42	13	7	10	5	10	11	1	0.235	1.000	1.000
269	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(9), PRKACG(1), PRKAG1(1), PRKAR2B(1)	11980933	12	8	12	5	2	0	1	7	1	1	0.828	1.000	1.000
270	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(3), DLG4(6), EPHB2(5), F2(4), F2RL1(4), F2RL3(3), MAP2K5(2), MAPK1(4), MAPK7(6), MAPK8(2), MYEF2(3), PLD1(8), PLD3(1), PTK2(2), RAF1(2), RASAL1(5), SRC(2), TEC(4), VAV1(9)	32644368	75	53	74	20	24	12	9	21	9	0	0.0755	1.000	1.000
271	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(4), GNB1(1), PPP2CA(4), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1)	18254383	27	18	27	6	11	2	0	11	3	0	0.297	1.000	1.000
272	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), DDC(5), EPX(7), GOT1(2), GOT2(1), HPD(1), LPO(5), MAOA(3), MAOB(2), MPO(4), PRDX1(1), TAT(3), TPO(10)	26119457	63	45	62	18	33	10	5	11	3	1	0.0428	1.000	1.000
273	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(4), EIF2S2(2), EIF2S3(2), GSK3B(1), PPP1CA(1)	13718454	13	11	13	9	1	2	4	4	2	0	0.958	1.000	1.000
274	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(4), ESR1(3), ESR2(6), ESRRA(2), HNF4A(7), NPM1(3), NR0B1(1), NR1D1(1), NR1D2(1), NR1H2(4), NR1H3(5), NR1I2(2), NR1I3(1), NR2C2(3), NR2E1(2), NR2F1(1), NR2F2(5), NR3C1(3), NR4A1(3), NR4A2(1), NR5A1(1), NR5A2(2), PGR(9), PPARA(4), PPARG(3), RARB(3), ROR1(3), RORA(1), RORC(4), RXRA(4), RXRB(1), RXRG(3), THRA(5), THRB(2), VDR(2)	50022598	108	75	105	27	41	15	15	26	11	0	0.0234	1.000	1.000
275	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(12), BMPR1B(1), CCND2(2), CDK4(1), CDKN1B(4), CEBPB(2), DMC1(2), EGR1(5), ESR2(6), FSHR(3), GJA4(1), LHCGR(2), MLH1(4), MSH5(2), NCOR1(9), NR5A1(1), NRIP1(4), PGR(9), PRLR(2), SMPD1(1), VDR(2), ZP2(6)	41666246	81	55	80	20	14	17	10	24	15	1	0.170	1.000	1.000
276	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(1), HLA-A(1), IL18(3), ITGB1(3), KLRC1(3), KLRC2(5), KLRD1(1), LAT(2), MAP2K1(1), MAPK3(2), PAK1(3), PTK2B(5), PTPN6(1), RAC1(1), VAV1(9)	17642014	41	27	40	13	10	4	5	10	11	1	0.418	1.000	1.000
277	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(2), RPN1(1), RPN2(1), UBE3A(1)	15318200	18	11	18	6	4	5	4	2	3	0	0.534	1.000	1.000
278	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	11	ACE2(7), AGT(3), AGTR1(1), AGTR2(4), CMA1(3), COL4A1(4), COL4A2(7), COL4A3(1), COL4A4(11), COL4A5(11), COL4A6(9)	29074358	61	42	60	22	17	19	8	11	5	1	0.273	1.000	1.000
279	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(3), RPE(1), UCHL3(1), UGDH(1), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(3), UGT2B4(9)	20876975	41	33	40	13	12	7	6	13	3	0	0.267	1.000	1.000
280	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	18	CSNK2A1(3), ELK1(5), FOS(2), INSR(6), IRS1(8), MAP2K1(1), MAPK3(2), MAPK8(2), RAF1(2), RASA1(4), SHC1(1), SLC2A4(1), SOS1(7), SRF(3)	24369384	47	35	47	14	13	12	4	8	9	1	0.227	1.000	1.000
281	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(3), ASNS(4), CA1(1), CA12(3), CA14(1), CA2(1), CA5A(1), CA6(1), CA9(1), CPS1(8), CTH(2), GLS(3), GLS2(1), GLUD1(4), GLUL(2), HAL(3)	22558785	39	31	39	11	13	7	3	10	6	0	0.262	1.000	1.000
282	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(3), AXIN1(4), BTRC(2), CCND1(4), CREBBP(13), CSNK1A1(2), CSNK1D(2), CSNK2A1(3), CTBP1(5), CTNNB1(3), DVL1(1), FZD1(3), GSK3B(1), MAP3K7(3), NLK(1), PPP2CA(4), WIF1(3), WNT1(1)	34931567	58	38	58	13	11	9	8	16	14	0	0.110	1.000	1.000
283	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(1), ADSL(4), AGXT(2), AGXT2(2), ASL(2), ASNS(4), ASPA(1), CAD(8), CRAT(2), DARS(1), GAD1(3), GAD2(1), GOT1(2), GOT2(1), NARS(1), PC(4)	30931428	43	27	43	8	8	11	4	12	8	0	0.0454	1.000	1.000
284	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(2), EIF4A1(7), EIF4A2(2), EIF4B(3), EIF4E(2), EIF4G1(5), EIF4G2(1), EIF4G3(7), MKNK1(2), PPP2CA(4), RPS6KB1(2), TSC1(2), TSC2(6)	27378252	45	33	45	11	12	10	6	13	4	0	0.147	1.000	1.000
285	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), AP2A1(1), AP2M1(1), BIN1(2), CALM1(1), CALM3(1), DNM1(1), EPN1(1), EPS15(3), PICALM(3), PPP3CA(1), PPP3CB(2), PPP3CC(1), SYNJ1(6), SYNJ2(12), SYT1(2)	25660797	42	27	42	13	15	5	7	7	8	0	0.240	1.000	1.000
286	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(3), IFNG(2), IFNGR1(1), IFNGR2(4), IKBKB(2), JAK2(5), NFKB1(2), NFKBIA(3), RELA(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), USH1C(3), WT1(3)	18575106	34	24	34	11	7	3	5	12	7	0	0.392	1.000	1.000
287	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(5), AKT1(2), CAMK2A(4), CAMK2D(1), CAMK2G(2), CREB1(2), GNAS(4), MAPK1(4), MAPK3(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), RAC1(1), RPS6KA1(5), RPS6KA5(2), SOS1(7)	30148353	52	38	52	11	20	5	7	9	9	2	0.0564	1.000	1.000
288	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), BCL2(3), CASP8(2), CYCS(2), MAP2K1(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), NFKB1(2), NSMAF(3), RAF1(2), RELA(1), RIPK1(4), SMPD1(1), TNFRSF1A(1), TRADD(1), TRAF2(2)	24399423	43	34	41	13	11	10	7	5	9	1	0.211	1.000	1.000
289	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), GALNT1(5), GALNT10(1), GALNT11(3), GALNT12(3), GALNT13(4), GALNT14(7), GALNT2(3), GALNT3(1), GALNT4(1), GALNT5(5), GALNT6(4), GALNT7(1), GALNT8(1), GALNT9(4), GALNTL1(1), GALNTL4(1), GALNTL5(1), GCNT1(2), GCNT3(2), GCNT4(3), OGT(9), ST3GAL1(3), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(11)	38364099	80	58	79	21	29	15	6	19	11	0	0.0914	1.000	1.000
290	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), CALM1(1), CALM3(1), CREB1(2), ELK1(5), FOS(2), GNAI1(4), GNAS(4), GNB1(1), MAP2K1(1), MAPK3(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), RAF1(2), RPS6KA3(4), SYT1(2)	41577812	79	62	77	21	22	9	10	21	15	2	0.0973	1.000	1.000
291	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM1(1), CALM3(1), CD3D(1), CD3E(2), CD3G(1), ELK1(5), FOS(2), FYN(2), LAT(2), LCK(1), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKBIA(3), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKCA(6), PTPN7(2), RAC1(1), RAF1(2), RASA1(4), RELA(1), SHC1(1), SOS1(7), SYT1(2), VAV1(9), ZAP70(8)	52364662	112	77	108	26	32	19	14	28	17	2	0.00574	1.000	1.000
292	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSS(2), NFKB1(2), NOX1(1), RELA(1), TNF(1), XDH(11)	11807172	19	12	19	9	5	5	0	8	1	0	0.721	1.000	1.000
293	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(3), CALM1(1), CALM3(1), ELK1(5), FCER1A(4), FOS(2), LYN(2), MAP2K1(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PAK2(2), PLA2G4A(7), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), RAF1(2), SHC1(1), SOS1(7), SYT1(2), VAV1(9)	46678358	98	68	94	25	20	22	16	27	12	1	0.0227	1.000	1.000
294	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(2), ALDH5A1(2), CAD(8), CPS1(8), EPRS(5), GAD1(3), GAD2(1), GCLC(1), GFPT1(5), GLS(3), GLS2(1), GLUD1(4), GLUL(2), GOT1(2), GOT2(1), GSS(2), NADSYN1(5), PPAT(2), QARS(5)	39363159	63	43	63	10	13	11	13	18	8	0	0.00722	1.000	1.000
295	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(3)	19677792	13	6	12	3	5	4	1	2	1	0	0.287	1.000	1.000
296	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(7), COL4A3(1), COL4A4(11), COL4A5(11), COL4A6(9), P4HB(1), SLC23A1(2), SLC23A2(3), SLC2A1(4), SLC2A3(5)	29859075	58	43	58	20	19	14	8	10	6	1	0.150	1.000	1.000
297	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(2), CHRNB1(2), CHRNG(3), MUSK(5), PTK2(2), PTK2B(5), RAPSN(1), SRC(2), TERT(5), YWHAH(2)	14947190	29	24	29	10	10	3	3	9	4	0	0.413	1.000	1.000
298	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA1(1), ACAA2(3), ACADM(2), ACADS(5), ACAT2(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ALDH7A1(2), AOX1(9), BCAT1(1), BCKDHA(1), BCKDHB(2), DBT(3), DLD(3), ECHS1(3), EHHADH(2), HADHA(3), HIBADH(1), HIBCH(2), HMGCS1(2), HMGCS2(3), HSD17B4(3), MCCC1(4), MCCC2(5), MUT(2), OXCT1(1), OXCT2(1), PCCA(3), PCCB(4)	51066936	94	60	90	22	32	22	10	16	14	0	0.0135	1.000	1.000
299	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), AOC2(1), ASPA(1), CNDP1(4), DDC(5), HAL(3), HARS(4), HDC(5), HNMT(1), MAOA(3), MAOB(2), PRPS1(1), PRPS2(5)	29032709	62	44	62	17	33	8	5	14	2	0	0.0585	1.000	1.000
300	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(2), CREB1(2), DAXX(5), DDIT3(2), ELK1(5), HMGN1(1), MAP3K1(9), MAP3K5(4), MAP3K7(3), MAP3K9(6), MAPKAPK2(2), MAPKAPK5(2), MEF2A(4), MEF2B(1), MEF2D(1), MKNK1(2), PLA2G4A(7), RAC1(1), RIPK1(4), RPS6KA5(2), SHC1(1), STAT1(4), TGFB2(2), TGFB3(1), TGFBR1(4), TRADD(1), TRAF2(2)	42896650	80	58	78	18	18	18	14	17	12	1	0.0261	1.000	1.000
301	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(3), AGTR1(1), ATF2(2), CALM1(1), CALM3(1), ELK1(5), MAP2K1(1), MAP2K2(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), MEF2A(4), MEF2B(1), MEF2D(1), PAK1(3), PRKCA(6), PTK2(2), PTK2B(5), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SRC(2), SYT1(2)	36716485	69	49	66	16	14	16	10	13	14	2	0.0304	1.000	1.000
302	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL4R(9), IRS1(8), JAK1(3), JAK3(5), RPS6KB1(2), SHC1(1), STAT6(5)	17620687	35	30	35	11	9	5	2	11	8	0	0.434	1.000	1.000
303	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(17), ACADL(1), ACADM(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ECHS1(3), EHHADH(2), HADHA(3), LDHA(1), LDHB(2), LDHC(1), MLYCD(4), MUT(2), PCCA(3), PCCB(4), SDS(1), SUCLA2(1), SUCLG1(2), SUCLG2(1)	39288675	77	48	77	21	23	20	6	17	11	0	0.0981	1.000	1.000
304	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3)	16093301	22	17	22	8	6	3	3	7	3	0	0.618	1.000	1.000
305	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ACY3(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDH7A1(2), AMDHD1(2), AOC2(1), ASPA(1), CARM1(1), CNDP1(4), DDC(5), FTCD(4), HAL(3), HARS(4), HARS2(1), HDC(5), HNMT(1), LCMT1(3), LCMT2(2), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), PRPS1(1), PRPS2(5), UROC1(2), WBSCR22(3)	47096984	97	64	97	26	44	12	10	23	8	0	0.0253	1.000	1.000
306	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	31	CRKL(2), DOCK1(3), ELK1(5), FOS(2), HGF(4), ITGA1(4), ITGB1(3), MAP2K1(1), MAP2K2(1), MAP4K1(3), MAPK1(4), MAPK3(2), MAPK8(2), MET(13), PAK1(3), PTK2(2), PTK2B(5), PXN(1), RAF1(2), RASA1(4), SOS1(7), SRC(2), STAT3(3)	45517708	78	54	77	20	23	11	10	19	14	1	0.0504	1.000	1.000
307	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(3), AXIN1(4), BTRC(2), CTNNB1(3), DLL1(1), DVL1(1), FZD1(3), GSK3B(1), PSEN1(1), WNT1(1)	20633462	20	16	20	9	3	2	2	7	6	0	0.904	1.000	1.000
308	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), CISH(1), IARS(4), IL13RA1(3), IL4R(9), INPP5D(5), JAK1(3), JAK2(5), JAK3(5), NR0B2(1), PI3(2), PPP1R13B(1), RPS6KB1(2), SERPINA4(2), SHC1(1), SOS1(7), SOS2(5), SRC(2), STAT6(5), TYK2(10)	41301731	75	55	75	12	24	8	8	24	11	0	0.00476	1.000	1.000
309	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), IL5(1), MAF(3), MAP2K3(6), NFATC1(2), NFATC2(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1)	14507874	27	19	27	11	12	1	3	8	3	0	0.422	1.000	1.000
310	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(4), ACADM(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AOC2(1), CNDP1(4), DPYD(6), DPYS(5), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), HIBCH(2), MLYCD(4), SMS(2), SRM(2)	32059072	63	37	62	17	23	11	4	16	9	0	0.0750	1.000	1.000
311	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(3), HPSE(5), HPSE2(5), HYAL1(3), HYAL2(1), IDS(2), LCT(13), NAGLU(3)	23158084	42	29	42	13	17	4	6	9	6	0	0.325	1.000	1.000
312	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(2), BCL2(3), BCR(3), CRKL(2), FOS(2), JAK2(5), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), RAF1(2), SOS1(7), STAT1(4), STAT5A(1), STAT5B(2)	28876451	47	33	45	12	9	11	6	12	7	2	0.100	1.000	1.000
313	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CAMK4(3), ESRRA(2), HDAC5(1), MEF2A(4), MEF2B(1), MEF2D(1), PPARA(4), PPP3CA(1), PPP3CB(2), PPP3CC(1), SLC2A4(1), SYT1(2), YWHAH(2)	24081629	37	21	37	12	8	9	6	6	8	0	0.305	1.000	1.000
314	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(1), ALDOB(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), GAPDH(1), GAPDHS(2), GCK(2), GOT1(2), GOT2(1), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHAL6B(2), LDHB(2), LDHC(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PFKL(5), PFKP(1), PGAM2(1), PGK1(3), PGK2(1), PKLR(4), TNFAIP1(3), TPI1(1)	49532347	90	65	88	23	34	24	3	19	10	0	0.00761	1.000	1.000
315	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(3), PIGA(3), PIGB(1), PIGC(1), PIGF(1), PIGG(1), PIGN(2), PIGO(5), PIGQ(3), PIGS(2), PIGT(1), PIGU(2), PIGW(2), PIGX(1), PIGZ(2)	28358561	32	15	32	8	11	3	6	7	5	0	0.199	1.000	1.000
316	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(3), CDH1(4), CREBBP(13), EP300(6), MAP2K1(1), MAP3K7(3), MAPK3(2), SKIL(3), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5)	30471747	47	28	47	11	10	9	7	13	7	1	0.153	1.000	1.000
317	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(2), NFKB1(2), RELA(1), TNFRSF13B(1), TNFRSF17(1), TNFSF13B(1), TRAF2(2), TRAF3(1), TRAF5(3)	17285578	15	10	15	9	6	4	2	1	2	0	0.845	1.000	1.000
318	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(1), CREB1(2), CREB3(3), DUSP4(1), DUSP9(2), EEF2K(2), EIF4E(2), MAP2K1(1), MAP2K2(1), MAP3K8(4), MAPK1(4), MAPK3(2), MKNK1(2), NFKB1(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), SHC1(1), SOS1(7), SOS2(5), TRAF3(1)	33356938	57	36	57	16	15	5	7	17	12	1	0.294	1.000	1.000
319	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(1), ACADS(5), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH5A1(2), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), L2HGDH(1), OXCT1(1), PDHA1(6), PDHA2(7), PDHB(1), SDS(1)	30627195	62	46	59	21	21	13	5	11	12	0	0.164	1.000	1.000
320	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(5), G6PD(3), GCLC(1), GGT1(3), GPX1(1), GPX2(2), GPX4(2), GPX5(1), GPX6(1), GSS(2), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(3), GSTA5(4), GSTK1(2), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), OPLAH(3)	24200498	44	31	44	14	15	12	6	7	4	0	0.193	1.000	1.000
321	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(7), ARRB2(1), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CLCA1(5), CLCA2(5), CLCA4(2), CNGA3(4), CNGA4(4), CNGB1(5), GNAL(1), GUCA1A(1), GUCA1C(1), PDC(2), PDE1C(9), PRKACG(1), PRKG1(2), PRKG2(6), PRKX(1)	36222503	73	51	73	22	32	12	7	13	9	0	0.0992	1.000	1.000
322	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B10(3), B4GALT2(1), G6PC2(1), GAA(6), GALE(2), GALK1(1), GALK2(1), GALT(1), GANC(5), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(5), HK3(5), HSD3B7(1), LCT(13), MGAM(15), PFKL(5), PFKP(1), PGM1(1), PGM3(1), UGP2(1)	45054433	79	52	79	21	40	11	6	16	6	0	0.0265	1.000	1.000
323	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(4), CALM1(1), CALM3(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), F2(4), FYN(2), GNA11(1), GNAI1(4), GNB1(1), JAK2(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MAPK8(2), MYLK(7), PLCG1(12), PRKCA(6), PTK2B(5), RAF1(2), SHC1(1), SOS1(7), STAT1(4), STAT3(3), STAT5A(1), SYT1(2)	49530850	93	64	91	25	22	11	19	24	14	3	0.0526	1.000	1.000
324	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(3), CALM1(1), CALM3(1), CD79A(1), ELK1(5), FOS(2), LYN(2), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKCA(6), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SYT1(2), VAV1(9)	45429368	91	62	87	26	22	18	12	23	14	2	0.0728	1.000	1.000
325	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM3(1), CHUK(1), EGR2(2), EGR3(2), MAP3K1(9), NFATC1(2), NFATC2(7), NFKB1(2), NFKBIA(3), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RELA(1), SYT1(2), VIP(2), VIPR2(2)	33245490	58	46	54	18	13	10	6	20	9	0	0.251	1.000	1.000
326	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP10(2), CASP8(2), CFLAR(1), DAXX(5), DFFA(2), FAF1(4), LMNA(2), LMNB2(3), MAP3K1(9), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(14), PTPN13(4), RIPK2(1), SPTAN1(8)	46493862	68	46	65	13	13	19	11	15	9	1	0.0102	1.000	1.000
327	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(17), ACACB(18), ACAT2(1), ACOT12(1), ACSS1(1), ACSS2(4), ACYP1(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), DLD(3), HAGH(1), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), LDHD(1), ME1(2), ME2(2), ME3(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PKLR(4)	55547755	106	81	104	28	39	22	7	25	13	0	0.0277	1.000	1.000
328	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(5), F2(4), F2R(2), FGA(12), FGB(4), FGG(6), PLAT(3), PLAU(1), PLG(6), SERPINB2(3), SERPINE1(4)	15900021	51	43	50	19	15	9	7	14	6	0	0.482	1.000	1.000
329	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), DARS(1), EPRS(5), FARS2(3), GARS(3), HARS(4), IARS(4), KARS(2), LARS(4), MARS(7), MARS2(2), NARS(1), QARS(5), RARS(3), SARS(1), TARS(1), WARS(1), WARS2(2), YARS(1)	38024325	54	36	54	12	8	14	6	18	8	0	0.161	1.000	1.000
330	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	7	ACO2(4), FH(1), OGDH(1), SDHA(4), SUCLA2(1)	10221978	11	9	10	8	4	1	4	1	1	0	0.907	1.000	1.000
331	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPL13(1), MRPS7(3), RPL10L(3), RPL11(2), RPL13A(2), RPL18A(1), RPL22L1(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL37A(1), RPL3L(1), RPL6(1), RPL7(3), RPS11(1), RPS12(2), RPS18(2), RPS2(1), RPS21(1), RPS24(1), RPS3(3), RPS5(1), RPSA(2)	26894393	39	26	38	9	12	1	6	10	10	0	0.468	1.000	1.000
332	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(4), ALDH4A1(2), ALDH5A1(2), CAD(8), CPS1(8), EARS2(1), EPRS(5), GAD1(3), GAD2(1), GCLC(1), GFPT1(5), GFPT2(3), GLS(3), GLS2(1), GLUD1(4), GLUD2(4), GLUL(2), GNPNAT1(2), GOT1(2), GOT2(1), GSS(2), NADSYN1(5), PPAT(2), QARS(5)	46864475	77	52	77	18	15	13	15	23	11	0	0.0681	1.000	1.000
333	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	24	GUSB(3), RPE(1), UGDH(1), UGP2(1), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(9), UGT2B10(7), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), XYLB(1)	31120904	77	61	75	25	22	8	13	29	5	0	0.357	1.000	1.000
334	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(3), ILVBL(5), LARS(4), PDHA1(6), PDHA2(7), PDHB(1), VARS(4), VARS2(3)	22075375	38	26	36	11	6	10	4	12	6	0	0.329	1.000	1.000
335	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(5), DDX20(1), E2F1(1), E2F4(1), ETS1(5), ETV3(1), FOS(2), HDAC2(7), HDAC5(1), NCOR2(9), RBL1(6), RBL2(3), SIN3A(5), SIN3B(1)	30957249	48	30	47	15	11	8	5	12	12	0	0.438	1.000	1.000
336	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF2(2), HLA-DRA(4), HLA-DRB1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL15(2), IL1A(1), IL3(2), IL5(1), IL6(2), IL7(1), PDGFA(1), TGFB2(2), TGFB3(1), TNF(1)	15750234	32	25	32	12	8	5	6	9	4	0	0.483	1.000	1.000
337	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	AGT(3), AKT1(2), CALM1(1), CALM3(1), CALR(2), CAMK1(2), CAMK1G(1), CAMK4(3), CREBBP(13), CSNK1A1(2), ELSPBP1(3), F2(4), GATA4(3), GSK3B(1), IGF1(3), MAP2K1(1), MAPK1(4), MAPK3(2), MAPK8(2), MYH2(25), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NPPA(2), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RAF1(2), RPS6KB1(2), SYT1(2)	55876120	111	77	110	27	37	11	15	30	17	1	0.0104	1.000	1.000
338	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(2), AKT1(2), BTK(3), CDKN2A(6), GSK3B(1), IARS(4), INPP5D(5), PDK1(2), PPP1R13B(1), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SOS1(7), SOS2(5), TEC(4), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1)	39150151	72	50	71	20	12	13	12	23	12	0	0.166	1.000	1.000
339	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT1(2), CAB39(2), EIF4B(3), FIGF(2), IGF1(3), MAPK1(4), MAPK3(2), PGF(1), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PRKAA1(3), PRKAA2(2), RICTOR(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(3), STK11(1), TSC1(2), TSC2(6), ULK1(2), ULK2(7), VEGFA(4), VEGFB(3), VEGFC(3)	57063273	110	74	109	28	32	17	17	29	14	1	0.0363	1.000	1.000
340	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), GLI2(5), GLI3(6), GSK3B(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), SHH(3), SMO(3), SUFU(4)	19834608	30	22	30	11	10	6	3	7	4	0	0.502	1.000	1.000
341	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	25	ACLY(4), ACO1(6), ACO2(4), CLYBL(5), DLD(3), FH(1), IDH3A(1), IDH3B(1), OGDH(1), OGDHL(7), PC(4), PCK1(6), SDHA(4), SDHC(2), SUCLA2(1), SUCLG1(2), SUCLG2(1)	33465035	53	42	52	16	13	10	8	17	5	0	0.214	1.000	1.000
342	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(3), ACTN2(6), ACTN3(1), CAPN1(2), CAPNS1(2), CAPNS2(1), ITGA1(4), ITGB1(3), ITGB3(4), PTK2(2), PXN(1), RAC1(1), SPTAN1(8), SRC(2), TLN1(5)	33881972	45	28	45	8	15	4	8	14	4	0	0.0396	1.000	1.000
343	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(3), APC(3), ATF2(2), AXIN1(4), BMP10(2), BMP2(1), BMP4(3), BMP5(8), BMPR1A(1), BMPR2(1), CHRD(2), CTNNB1(3), DVL1(1), FZD1(3), GATA4(3), GSK3B(1), MAP3K7(3), MYL2(2), NPPA(2), RFC1(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TGFBR3(3), WNT1(1)	43278799	66	46	66	12	19	11	9	13	14	0	0.0134	1.000	1.000
344	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	CPEB1(4), ERBB2(3), ERBB4(5), ETS1(5), ETV6(4), ETV7(1), FMN2(3), KRAS(5), MAP2K1(1), MAPK1(4), MAPK3(2), NOTCH2(16), NOTCH3(7), NOTCH4(10), PIWIL1(2), PIWIL2(5), PIWIL3(5), PIWIL4(2), RAF1(2), SOS1(7), SOS2(5), SPIRE1(2), SPIRE2(3)	52425761	103	68	100	26	27	20	17	22	15	2	0.0558	1.000	1.000
345	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(4), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), DDC(5), EPX(7), ESCO1(2), ESCO2(2), GOT1(2), GOT2(1), HPD(1), LPO(5), MAOA(3), MAOB(2), MPO(4), PNPLA3(1), SH3GLB1(3), TAT(3), TPO(10)	40655346	70	47	69	19	34	14	5	13	4	0	0.0379	1.000	1.000
346	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM3(1), DLG4(6), GRIN1(3), GRIN2A(17), GRIN2B(9), GRIN2C(6), GRIN2D(5), NOS1(10), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), SYT1(2)	30363151	75	64	75	27	38	7	9	15	5	1	0.236	1.000	1.000
347	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(2), CCR3(2), CFL1(1), GNAS(4), GNB1(1), LIMK1(4), MAP2K1(1), MAPK1(4), MAPK3(2), MYL2(2), NOX1(1), PIK3C2G(10), PLCB1(4), PPP1R12B(1), PRKCA(6), PTK2(2), RAF1(2), ROCK2(5)	29930335	54	44	54	15	13	5	12	14	8	2	0.270	1.000	1.000
348	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	32	AKT1(2), ASAH1(2), DAG1(3), DRD2(1), EPHB2(5), ITPR1(9), ITPR2(15), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), PI3(2), PIK3CB(7), PITX2(7), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), RAF1(2), SHC1(1), SOS1(7), SOS2(5), SRC(2), STAT3(3), TERF2IP(1)	64713989	123	82	123	28	34	22	24	32	10	1	0.00374	1.000	1.000
349	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(3), ATIC(1), ATP6V0C(1), DHFR(1), GART(4), MTHFD1(3), MTHFD1L(1), MTHFR(7), MTHFS(2), MTR(2), SHMT1(2)	21244740	30	13	30	11	7	7	7	3	5	1	0.372	1.000	1.000
350	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(1), ABAT(1), ACADS(5), ACAT2(1), ACSM1(6), AKR1B10(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH5A1(2), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), HMGCS1(2), HMGCS2(3), HSD17B4(3), HSD3B7(1), ILVBL(5), L2HGDH(1), OXCT1(1), OXCT2(1), PDHA1(6), PDHA2(7), PDHB(1), PLA1A(4), PPME1(1)	48179369	91	61	88	28	28	14	9	25	15	0	0.136	1.000	1.000
351	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(1), ABAT(1), ACY3(1), ADSL(4), ADSSL1(1), AGXT(2), AGXT2(2), ASL(2), ASNS(4), ASPA(1), ASS1(4), CAD(8), CRAT(2), DARS(1), DARS2(2), DLD(3), GAD1(3), GAD2(1), GOT1(2), GOT2(1), NARS(1), NARS2(1), PC(4), PDHA1(6), PDHA2(7), PDHB(1)	44935938	70	49	67	18	18	18	6	15	13	0	0.0800	1.000	1.000
352	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(5), CD2(1), CD33(6), CD5(2), CD7(3), CSF2(2), IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL3(2), IL5(1), ITGAX(8), TLR2(5), TLR4(2), TLR7(10), TLR9(5)	22060400	61	51	60	23	22	5	7	20	7	0	0.531	1.000	1.000
353	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2D(1), CAMK2G(2), DAG1(3), ITPR1(9), ITPR2(15), ITPR3(18), NFAT5(3), PDE6A(4), PDE6B(5), PDE6C(7), SLC6A13(4), TF(2)	42628421	77	52	77	24	29	16	12	12	7	1	0.0648	1.000	1.000
354	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(1), NCK1(2), NCKAP1(5), NTRK1(4), RAC1(1), WASF1(1), WASF2(1), WASF3(4), WASL(2)	18128904	28	17	28	10	3	4	4	8	9	0	0.584	1.000	1.000
355	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CALM1(1), CALM3(1), CAPNS1(2), CAPNS2(1), EP300(6), HDAC2(7), MEF2D(1), NFATC1(2), NFATC2(7), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKCA(6), SYT1(2)	28934777	51	35	51	18	14	7	8	12	9	1	0.437	1.000	1.000
356	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(2), MAP2K1(1), MAPK1(4), MAPK3(2), NFKB1(2), NFKBIA(3), PLCB1(4), PRKCA(6), RAF1(2), RELA(1), TNF(1)	18426233	28	23	28	11	6	3	4	8	5	2	0.536	1.000	1.000
357	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(6), ATM(12), BRCA1(6), CDKN1A(2), CHEK1(6), CHEK2(3), MAPK8(2), MDM2(5), MRE11A(3), NFKB1(2), NFKBIA(3), RAD50(6), RBBP8(3), RELA(1)	34444498	60	40	60	17	16	9	9	16	10	0	0.335	1.000	1.000
358	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(2), CRADD(2), DFFA(2), LMNA(2), LMNB2(3), MADD(3), MAP3K1(9), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(14), RIPK1(4), SPTAN1(8), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2)	44108491	67	52	64	17	17	17	10	13	9	1	0.0621	1.000	1.000
359	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(1), ALOX15(2), ALOX5(2), CBR1(2), CBR3(1), CYP4F2(3), CYP4F3(6), EPX(7), GGT1(3), LPO(5), LTA4H(4), MPO(4), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PRDX1(1), PTGES2(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(2), TPO(10)	33130213	80	60	80	25	32	15	6	16	10	1	0.0877	1.000	1.000
360	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACPP(4), ACPT(2), ALPI(2), ALPP(7), ALPPL2(6), CYP19A1(2), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(6), CYP2C18(3), CYP2C19(6), CYP2C8(4), CYP2C9(3), CYP2D6(2), CYP2E1(2), CYP2F1(1), CYP3A4(5), CYP3A7(6), CYP4B1(5), CYP4F8(3), CYP51A1(2), PON1(4)	34718056	83	74	81	26	41	6	9	15	12	0	0.176	1.000	1.000
361	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(2), BRD4(1), CBL(2), CDKN2A(6), FLOT1(2), FLOT2(3), GSK3B(1), INPPL1(8), IRS1(8), IRS2(1), IRS4(7), LNPEP(3), MAPK1(4), MAPK3(2), PARD3(3), PARD6A(1), PDK1(2), PIK3CD(3), PPYR1(1), PTPN1(1), RAF1(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SLC2A4(1), SORBS1(3), SOS1(7), SOS2(5), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1)	65171607	109	74	108	27	19	15	18	33	23	1	0.0544	1.000	1.000
362	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	23	B4GALT2(1), FBP2(2), GAA(6), GALE(2), GALK1(1), GALK2(1), GALT(1), GANAB(5), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(5), HK3(5), LCT(13), MGAM(15), PFKP(1), PGM1(1), PGM3(1)	37829259	70	48	70	21	36	11	6	12	5	0	0.0743	1.000	1.000
363	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ADC(4), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AMD1(2), AOC2(1), ARG2(2), ASL(2), ASS1(4), CPS1(8), GATM(2), MAOA(3), MAOB(2), NAGS(1), ODC1(3), OTC(2), SMS(2), SRM(2)	35038014	62	45	61	20	23	7	7	16	9	0	0.353	1.000	1.000
364	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(2), GHR(4), INSR(6), IRS1(8), JAK2(5), MAP2K1(1), MAPK1(4), MAPK3(2), PLCG1(12), PRKCA(6), PTPN6(1), RAF1(2), RPS6KA1(5), SHC1(1), SLC2A4(1), SOCS1(1), SOS1(7), SRF(3), STAT5A(1), STAT5B(2)	34806143	74	55	72	23	16	15	11	19	11	2	0.243	1.000	1.000
365	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(3), ASAH1(2), CREB1(2), CREB3(3), DAG1(3), EPHB2(5), FOS(2), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2)	33996203	42	34	42	13	10	7	11	6	8	0	0.286	1.000	1.000
366	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CYP2C19(6), CYP2C9(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(3), EHHADH(2), ESCO1(2), ESCO2(2), HADHA(3), PNPLA3(1), SH3GLB1(3), YOD1(1)	36702728	52	33	51	16	23	10	5	7	7	0	0.168	1.000	1.000
367	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), ANKRD6(4), APC(3), AXIN1(4), AXIN2(2), CSNK1A1(2), CTNNB1(3), DACT1(4), DKK1(2), DKK2(5), DKK4(2), DVL1(1), FSTL1(1), GSK3B(1), LRP1(29), MVP(3), NKD1(2), NKD2(4), PSEN1(1), PTPRA(7), SENP2(3), SFRP1(1), WIF1(3)	47989360	89	61	88	26	28	12	10	23	16	0	0.252	1.000	1.000
368	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(2), APC(3), AXIN1(4), CCND1(4), CD14(1), CTNNB1(3), DVL1(1), FZD1(3), GJA1(5), GNAI1(4), GSK3B(1), IRAK1(3), LBP(5), LEF1(1), LY96(2), NFKB1(2), PPP2CA(4), RELA(1), TLR4(2), TOLLIP(1), WNT1(1)	32092744	53	40	53	18	16	9	10	11	7	0	0.374	1.000	1.000
369	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(6), ABCC2(1), ABCG2(3), BCHE(2), CES1(3), CES2(2), CYP3A4(5), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2)	27104779	45	35	44	17	17	4	9	9	6	0	0.376	1.000	1.000
370	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), CEL(4), DGAT1(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(2), GK(3), GLA(2), GLB1(2), LCT(13), LIPC(1), LIPF(1), LIPG(4), LPL(2), PNLIP(2), PNLIPRP1(4), PPAP2A(2), PPAP2C(1)	57264992	118	75	118	30	44	18	13	31	12	0	0.00944	1.000	1.000
371	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(5), DIAPH1(5), FYN(2), GSN(2), ITGA1(4), ITGB1(3), MAP2K1(1), MAPK1(4), MAPK3(2), MYL2(2), MYLK(7), PTK2(2), PXN(1), RAF1(2), ROCK1(4), SHC1(1), SRC(2), TLN1(5)	39887590	54	36	53	16	14	3	11	17	8	1	0.269	1.000	1.000
372	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(4), AOC2(1), CES1(3), ESCO1(2), ESCO2(2), LIPA(2), PLA1A(4), PNPLA3(1), PPME1(1), SH3GLB1(3)	30113623	24	15	24	6	9	6	1	6	2	0	0.211	1.000	1.000
373	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(2), CABIN1(11), CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), HDAC5(1), IGF1(3), IGF1R(10), INSR(6), MAPK7(6), MEF2A(4), MEF2B(1), MEF2D(1), MYOD1(1), NFATC1(2), NFATC2(7), PPP3CA(1), PPP3CB(2), PPP3CC(1), SYT1(2), YWHAH(2)	36892388	68	48	68	24	19	11	11	16	11	0	0.280	1.000	1.000
374	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(2), EIF4A1(7), EIF4A2(2), EIF4E(2), EIF4G1(5), EIF4G2(1), EIF4G3(7), GHR(4), IRS1(8), MAPK1(4), MAPK3(2), MKNK1(2), PABPC1(4), PRKCA(6), RPS6KB1(2)	27965761	58	39	58	18	16	11	9	11	9	2	0.342	1.000	1.000
375	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(12), ATR(10), BRCA1(6), CCNB1(2), CDC25A(1), CDC25B(1), CDC34(2), CDKN1A(2), CHEK1(6), CHEK2(3), EP300(6), MDM2(5), MYT1(7), PRKDC(14), RPS6KA1(5), WEE1(2), YWHAH(2), YWHAQ(1)	48865857	87	61	87	24	20	13	11	22	20	1	0.296	1.000	1.000
376	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(3), ACADL(1), ACADM(2), ACADS(5), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), AOX1(9), BCAT1(1), BCKDHA(1), BCKDHB(2), ECHS1(3), EHHADH(2), HADHA(3), HIBADH(1), MCCC1(4), MCCC2(5), MUT(2), OXCT1(1), PCCA(3), PCCB(4), SDS(1)	42731475	80	52	76	27	27	21	9	13	10	0	0.187	1.000	1.000
377	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AGK(1), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), AKR1A1(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CEL(4), DAK(2), DGAT1(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(2), GK(3), GK2(5), GLA(2), GLB1(2), GPAM(1), LCT(13), LIPA(2), LIPC(1), LIPF(1), LIPG(4), LPL(2), MGLL(1), PNLIP(2), PNLIPRP1(4), PNPLA3(1), PPAP2A(2), PPAP2C(1)	69729701	134	82	133	32	50	17	16	37	14	0	0.00396	1.000	1.000
378	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(4), ACADL(1), ACADM(2), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), AOC2(1), CNDP1(4), DPYD(6), DPYS(5), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), MLYCD(4), SDS(1), SMS(2)	34500000	63	39	62	23	23	12	3	16	9	0	0.347	1.000	1.000
379	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(3), B4GALT2(1), DPAGT1(2), DPM1(3), FUT8(7), MAN1A1(3), MAN1B1(1), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), RPN1(1), RPN2(1), ST6GAL1(2)	23603810	40	27	40	14	10	11	5	5	9	0	0.313	1.000	1.000
380	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREB1(2), CREBBP(13), EP300(6), NCOA3(4), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RXRA(4)	24573494	35	26	35	13	10	5	2	10	8	0	0.658	1.000	1.000
381	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(13), DUSP1(1), EP300(6), IKBKB(2), IL1B(3), MAP2K3(6), MAP3K7(3), NFKB1(2), NFKBIA(3), NR3C1(3), RELA(1), TGFBR1(4), TGFBR2(5), TLR2(5), TNF(1)	35255518	59	41	59	19	14	13	7	14	11	0	0.289	1.000	1.000
382	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNB1(2), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1RAP(2), IL1RN(2), IL6(2), IRAK1(3), IRAK2(3), IRAK3(9), MAP2K3(6), MAP3K1(9), MAP3K7(3), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), TGFB2(2), TGFB3(1), TNF(1), TOLLIP(1)	35216894	65	49	63	21	16	17	9	13	10	0	0.179	1.000	1.000
383	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT(2), AGXT2(2), AKR1B10(3), ALAS1(2), ALAS2(1), AMT(3), AOC2(1), CBS(5), CHKB(1), CTH(2), DAO(3), DLD(3), DMGDH(4), GAMT(1), GARS(3), GATM(2), GCAT(2), GLDC(3), HSD3B7(1), MAOA(3), MAOB(2), PHGDH(5), PIPOX(2), PISD(2), PSAT1(4), PSPH(2), SARDH(3), SARS(1), SARS2(2), SDS(1), SHMT1(2), TARS(1), TARS2(2)	50787547	80	56	80	23	25	20	5	22	8	0	0.0630	1.000	1.000
384	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(13), EP300(6), HDAC3(1), IKBKB(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1)	26596690	39	26	39	14	11	6	2	11	9	0	0.515	1.000	1.000
385	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BCL2(3), BIRC2(3), BIRC3(1), CASP10(2), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CYCS(2), DFFA(2), GAS2(1), LMNA(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), SPTAN1(8), TNFRSF25(2), TNFSF10(2), TRADD(1), TRAF2(2)	39721073	49	36	49	14	13	7	5	16	8	0	0.299	1.000	1.000
386	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	35	ARSA(1), ARSD(3), ARSE(6), ASAH1(2), B4GALT6(2), DEGS1(2), DEGS2(2), ENPP7(4), GAL3ST1(2), GALC(1), GBA(1), GLA(2), GLB1(2), LCT(13), NEU1(2), NEU3(2), NEU4(2), PPAP2A(2), PPAP2C(1), SGMS2(3), SGPP1(1), SGPP2(3), SMPD1(1), SMPD2(1), SMPD3(2), SMPD4(1), SPTLC1(2), SPTLC2(2), UGCG(2), UGT8(2)	41633325	72	46	72	25	26	10	12	20	3	1	0.281	1.000	1.000
387	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(6), AMY2B(6), ENPP1(5), ENPP3(2), GAA(6), GANAB(5), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(5), HK3(5), MGAM(15), PGM1(1), PGM3(1), PYGB(3), PYGL(6), PYGM(2), SI(11), UCHL3(1), UGDH(1), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(3), UGT2B4(9), UXS1(4)	66862762	135	94	134	32	51	24	15	30	15	0	0.00361	1.000	1.000
388	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(3), BAK1(2), BAX(1), BCL2(3), BIRC2(3), BIRC3(1), CASP2(1), CASP8(2), CASP9(1), CYCS(2), FAS(1), FASLG(1), GZMB(3), MAP3K1(9), MAPK10(1), MCL1(1), MDM2(5), NFKB1(2), NFKBIA(3), PARP1(3), PRF1(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFSF10(2), TRADD(1), TRAF1(1), TRAF2(2)	43465381	67	57	65	23	18	12	9	17	11	0	0.385	1.000	1.000
389	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), BCL2(3), GSK3B(1), IL4R(9), IRS1(8), IRS2(1), JAK1(3), JAK3(5), MAP4K1(3), MAPK1(4), MAPK3(2), PDK1(2), PIK3CD(3), PPP1R13B(1), RAF1(2), SHC1(1), SOCS1(1), SOS1(7), SOS2(5), STAT6(5)	38936559	68	52	68	22	16	8	7	23	13	1	0.434	1.000	1.000
390	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	186	ACTB(2), ACTG1(1), ACTN1(3), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(2), ARHGAP5(5), BCAR1(3), BCL2(3), BIRC2(3), BIRC3(1), CAV3(1), CCND1(4), CCND2(2), CCND3(1), CHAD(1), COL11A1(9), COL11A2(11), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(7), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(9), COL6A3(28), COL6A6(8), COMP(1), CRKL(2), CTNNB1(3), DIAPH1(5), DOCK1(3), EGF(10), ELK1(5), ERBB2(3), FARP2(2), FIGF(2), FLNA(18), FLNB(11), FLNC(15), FLT1(10), FN1(9), FYN(2), GSK3B(1), HGF(4), IBSP(1), IGF1(3), IGF1R(10), ILK(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGA7(4), ITGA8(6), ITGA9(2), ITGAV(3), ITGB1(3), ITGB3(4), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), KDR(14), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(7), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), MAP2K1(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(2), MET(13), MYL2(2), MYL5(1), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PARVA(1), PARVB(2), PARVG(1), PDGFA(1), PDGFC(2), PDGFD(4), PDGFRB(4), PGF(1), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(6), PRKCG(4), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), RAPGEF1(4), RELN(25), ROCK1(4), ROCK2(5), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), SPP1(2), SRC(2), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TLN1(5), TLN2(8), TNC(9), TNN(7), TNR(5), TNXB(14), VASP(1), VAV1(9), VAV2(4), VAV3(3), VCL(1), VEGFA(4), VEGFB(3), VEGFC(3), VWF(14), ZYX(2)	428403307	831	392	823	291	266	158	100	195	107	5	0.00885	1.000	1.000
391	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY7(3), ADCY8(3), ADCY9(11), ADRA1A(2), ADRA1B(2), ADRB2(1), AGTR1(1), ATP2A1(3), ATP2A2(4), ATP2A3(4), ATP2B2(8), ATP2B3(8), AVPR1A(6), AVPR1B(2), BDKRB1(1), BST1(1), CACNA1A(4), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1F(7), CACNA1G(7), CACNA1H(11), CACNA1I(9), CACNA1S(14), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CAMK4(3), CCKAR(1), CCKBR(3), CD38(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM5(4), CHRNA7(1), CYSLTR1(2), CYSLTR2(2), DRD1(1), EDNRA(1), EDNRB(1), ERBB2(3), ERBB3(4), ERBB4(5), F2R(2), GNA11(1), GNA14(3), GNA15(1), GNAL(1), GNAS(4), GRIN1(3), GRIN2A(17), GRIN2C(6), GRIN2D(5), GRM1(7), GRM5(6), GRPR(4), HRH1(3), HRH2(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), ITPR1(9), ITPR2(15), ITPR3(18), LHCGR(2), LTB4R2(1), MYLK(7), MYLK2(1), NOS1(10), NOS3(10), NTSR1(4), P2RX1(2), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), PDE1A(3), PDE1B(2), PDE1C(9), PDGFRB(4), PHKA1(5), PHKA2(5), PHKB(1), PHKG1(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(5), PPID(2), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PTAFR(2), PTGER3(2), PTGFR(7), PTK2B(5), RYR1(15), RYR2(58), RYR3(28), SLC25A4(1), SLC25A5(4), SLC25A6(1), SLC8A1(3), SLC8A2(3), SLC8A3(2), TACR2(2), TACR3(7), TBXA2R(1), TNNC1(1), TNNC2(1), TRHR(2), TRPC1(2), VDAC1(2), VDAC2(2), VDAC3(3)	314881319	676	363	669	239	286	99	75	132	81	3	0.00812	1.000	1.000
392	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(2), ACTG1(1), CHAD(1), COL11A1(9), COL11A2(11), COL17A1(5), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(7), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(9), COL6A3(28), COL6A6(8), COMP(1), DES(3), DSC1(6), DSC2(5), DSC3(9), DSG1(8), DSG2(7), DSG3(11), DSG4(7), FN1(9), GJA1(5), GJA10(2), GJA3(1), GJA4(1), GJA8(1), GJA9(1), GJB2(1), GJB3(2), GJB4(2), GJB6(2), GJC1(1), GJC3(2), GJD2(3), GJD4(1), IBSP(1), INA(1), ITGA6(5), ITGB4(8), KRT1(4), KRT12(3), KRT13(6), KRT14(2), KRT16(5), KRT17(1), KRT18(3), KRT19(1), KRT2(3), KRT20(5), KRT23(2), KRT24(3), KRT25(5), KRT27(2), KRT28(6), KRT3(4), KRT31(4), KRT32(1), KRT33A(7), KRT33B(3), KRT34(4), KRT35(4), KRT36(5), KRT37(7), KRT38(1), KRT39(4), KRT4(1), KRT40(3), KRT5(4), KRT6A(2), KRT6B(5), KRT6C(3), KRT7(1), KRT71(4), KRT73(5), KRT74(1), KRT75(6), KRT76(2), KRT77(1), KRT78(2), KRT79(6), KRT8(5), KRT81(4), KRT82(1), KRT83(4), KRT84(5), KRT86(4), KRT9(4), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(7), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), LMNA(2), LMNB2(3), NES(3), PRPH(1), RELN(25), SPP1(2), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNC(9), TNN(7), TNR(5), TNXB(14), VIM(2), VWF(14)	294998816	664	352	657	262	255	144	60	139	64	2	0.161	1.000	1.000
393	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	230	ADCYAP1R1(5), ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2B(2), ADRA2C(3), ADRB2(1), AGTR1(1), AGTR2(4), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), C5AR1(4), CALCRL(1), CCKAR(1), CCKBR(3), CGA(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CNR1(1), CNR2(3), CRHR2(5), CTSG(5), CYSLTR1(2), CYSLTR2(2), DRD1(1), DRD2(1), DRD3(3), EDNRA(1), EDNRB(1), F2(4), F2R(2), F2RL1(4), F2RL3(3), FPR1(1), FSHR(3), GABBR1(2), GABBR2(2), GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), GABRB1(6), GABRB3(8), GABRD(5), GABRE(5), GABRG1(7), GABRG2(6), GABRG3(2), GABRP(4), GABRQ(2), GABRR1(3), GABRR2(1), GALR1(2), GH1(2), GH2(3), GHR(4), GHRHR(3), GHSR(2), GIPR(2), GLP1R(2), GLP2R(3), GLRA1(2), GLRA2(2), GLRA3(3), GLRB(4), GNRHR(3), GPR156(2), GPR35(2), GPR50(3), GPR63(1), GPR83(4), GRIA1(8), GRIA2(2), GRIA3(10), GRIA4(5), GRID1(3), GRID2(5), GRIK1(6), GRIK2(4), GRIK3(6), GRIK4(5), GRIK5(3), GRIN1(3), GRIN2A(17), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRIN3A(5), GRIN3B(2), GRM1(7), GRM2(4), GRM3(16), GRM4(6), GRM5(6), GRM6(6), GRM7(5), GRM8(7), GRPR(4), GZMA(1), HCRTR1(1), HCRTR2(3), HRH1(3), HRH2(3), HRH3(3), HRH4(2), HTR1A(2), HTR1B(2), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), LEPR(3), LHCGR(2), LTB4R(1), LTB4R2(1), MC1R(3), MC2R(2), MC3R(6), MC4R(6), MC5R(5), MCHR1(2), MCHR2(3), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(6), NMUR1(4), NMUR2(6), NPBWR1(2), NPBWR2(4), NPFFR2(2), NPY1R(3), NPY2R(2), NPY5R(3), NR3C1(3), NTSR1(4), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), P2RX1(2), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), P2RY1(1), P2RY10(1), P2RY13(1), P2RY2(3), P2RY4(2), P2RY6(2), P2RY8(6), PARD3(3), PPYR1(1), PRL(1), PRLHR(1), PRLR(2), PRSS1(2), PRSS3(2), PTAFR(2), PTGER3(2), PTGER4(2), PTGFR(7), PTH2R(3), RXFP1(5), RXFP2(6), SCTR(1), SSTR2(3), SSTR3(6), SSTR5(1), TAAR1(1), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR2(2), TACR3(7), TBXA2R(1), THRA(5), THRB(2), TRHR(2), TRPV1(4), TSHR(5), UTS2R(2), VIPR1(1), VIPR2(2)	256871155	652	347	643	247	275	102	69	148	58	0	0.0209	1.000	1.000
394	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	240	ACVR1B(3), ACVR1C(3), AKT1(2), ARRB1(2), ARRB2(1), ATF2(2), ATF4(1), BDNF(1), CACNA1A(4), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1F(7), CACNA1G(7), CACNA1H(11), CACNA1I(9), CACNA1S(14), CACNA2D1(13), CACNA2D2(3), CACNA2D3(4), CACNA2D4(3), CACNB2(4), CACNB3(4), CACNB4(2), CACNG1(2), CACNG2(2), CACNG3(8), CACNG5(1), CACNG7(3), CACNG8(1), CD14(1), CDC25B(1), CHUK(1), CRKL(2), DAXX(5), DDIT3(2), DUSP1(1), DUSP10(2), DUSP14(1), DUSP16(3), DUSP4(1), DUSP5(4), DUSP7(1), DUSP9(2), EGF(10), ELK1(5), ELK4(1), FAS(1), FASLG(1), FGF13(3), FGF14(3), FGF16(1), FGF18(2), FGF22(1), FGF4(1), FGF5(3), FGF6(1), FGF7(2), FGFR1(3), FGFR2(3), FGFR3(5), FGFR4(5), FLNA(18), FLNB(11), FLNC(15), FOS(2), GADD45B(1), GNG12(1), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), KRAS(5), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP2K5(2), MAP3K1(9), MAP3K10(1), MAP3K12(6), MAP3K13(3), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K6(1), MAP3K7(3), MAP3K8(4), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(4), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK7(6), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2), MAPKAPK2(2), MAPKAPK3(2), MAPKAPK5(2), MKNK1(2), MRAS(1), NFATC2(7), NFATC4(5), NFKB1(2), NFKB2(2), NLK(1), NR4A1(3), NTF3(2), NTRK1(4), PAK1(3), PAK2(2), PDGFA(1), PDGFRB(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PPM1A(1), PPM1B(3), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PTPN5(1), PTPN7(2), PTPRR(6), RAC1(1), RAC2(1), RAF1(2), RAPGEF2(5), RASA1(4), RASA2(3), RASGRF1(7), RASGRF2(6), RASGRP1(2), RASGRP2(3), RASGRP3(2), RASGRP4(3), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA5(2), RPS6KA6(5), RRAS(1), SOS1(7), SOS2(5), SRF(3), STK3(3), STMN1(1), TAOK1(3), TAOK2(5), TAOK3(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TNF(1), TNFRSF1A(1), TRAF2(2), ZAK(2)	324029256	605	322	592	224	200	103	75	124	99	4	0.153	1.000	1.000
395	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	197	ABI2(3), ACTN1(3), ACTN2(6), ACTN3(1), ACTN4(2), APC(3), APC2(3), ARAF(1), ARHGEF1(1), ARHGEF12(4), ARHGEF4(4), ARHGEF6(7), ARHGEF7(2), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(1), BAIAP2(3), BCAR1(3), BDKRB1(1), CD14(1), CFL1(1), CFL2(2), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CRKL(2), CSK(2), CYFIP2(4), DIAPH1(5), DIAPH2(5), DIAPH3(4), DOCK1(3), EGF(10), EZR(4), F2(4), F2R(2), FGD1(1), FGD3(4), FGF13(3), FGF14(3), FGF16(1), FGF18(2), FGF22(1), FGF4(1), FGF5(3), FGF6(1), FGF7(2), FGFR1(3), FGFR2(3), FGFR3(5), FGFR4(5), FN1(9), GIT1(2), GNA13(1), GNG12(1), GSN(2), IQGAP1(9), IQGAP2(6), IQGAP3(4), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGA7(4), ITGA8(6), ITGA9(2), ITGAD(5), ITGAE(7), ITGAL(2), ITGAM(7), ITGAV(3), ITGAX(8), ITGB1(3), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), KRAS(5), LIMK1(4), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MRAS(1), MSN(2), MYH10(8), MYH14(7), MYH9(3), MYL2(2), MYL5(1), MYLK(7), MYLK2(1), NCKAP1(5), NCKAP1L(4), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PDGFA(1), PDGFRB(4), PFN4(1), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(1), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), RDX(5), ROCK1(4), ROCK2(5), RRAS(1), SCIN(2), SOS1(7), SOS2(5), SSH1(4), SSH2(2), SSH3(2), TIAM1(5), TIAM2(14), VAV1(9), VAV2(4), VAV3(3), VCL(1), WAS(3), WASF1(1), WASF2(1), WASL(2)	316287807	527	293	521	200	160	79	68	140	78	2	0.429	1.000	1.000
396	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(3), CD36(5), CD44(6), CHAD(1), COL11A1(9), COL11A2(11), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(7), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(9), COL6A3(28), COL6A6(8), DAG1(3), FN1(9), FNDC1(7), FNDC3A(5), FNDC4(1), FNDC5(1), GP5(2), GP6(1), GP9(1), HMMR(1), HSPG2(24), IBSP(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGA7(4), ITGA8(6), ITGA9(2), ITGAV(3), ITGB1(3), ITGB3(4), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(7), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), RELN(25), SDC1(2), SDC2(1), SDC3(1), SDC4(1), SPP1(2), SV2A(2), SV2B(5), SV2C(4), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNC(9), TNN(7), TNR(5), TNXB(14), VWF(14)	266533048	541	288	539	185	183	125	59	110	62	2	0.00670	1.000	1.000
397	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ADRA1A(2), ADRA1B(2), ADRB2(1), ANXA6(3), ARRB1(2), ARRB2(1), ATP1A4(2), ATP1B1(1), ATP1B2(1), ATP2A2(4), ATP2A3(4), ATP2B2(8), ATP2B3(8), CACNA1A(4), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1S(14), CACNB3(4), CALM1(1), CALM3(1), CALR(2), CAMK1(2), CAMK2A(4), CAMK2D(1), CAMK2G(2), CAMK4(3), CASQ1(2), CASQ2(3), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), GJA1(5), GJA4(1), GJB2(1), GJB3(2), GJB4(2), GJB6(2), GNA11(1), GNAI2(1), GNAI3(2), GNAO1(4), GNAZ(1), GNB1(1), GNB2(2), GNB3(1), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GNG5(1), GRK4(5), GRK5(4), ITPR1(9), ITPR2(15), ITPR3(18), KCNB1(5), KCNJ3(2), KCNJ5(5), MIB1(5), MYCBP(1), NME7(2), PEA15(1), PKIB(1), PLCB3(4), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCQ(4), PRKD1(1), RGS1(1), RGS11(1), RGS14(1), RGS18(2), RGS19(1), RGS3(11), RGS4(4), RGS6(3), RGS7(3), RGS9(4), RYR1(15), RYR2(58), RYR3(28), SFN(3), SLC8A1(3), SLC8A3(2), USP5(1), YWHAB(2), YWHAH(2), YWHAQ(1)	223287268	475	271	470	159	187	75	61	89	60	3	0.00895	1.000	1.000
398	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	248	ACVR1(3), ACVR1B(3), ACVR2A(2), AMHR2(2), BMP2(1), BMPR1A(1), BMPR1B(1), BMPR2(1), CCL1(1), CCL11(2), CCL13(1), CCL14(1), CCL15(1), CCL16(1), CCL19(1), CCL2(1), CCL20(1), CCL24(2), CCL26(2), CCL27(1), CCL3(1), CCL5(1), CCR1(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CCR9(2), CD40(1), CD40LG(2), CD70(2), CLCF1(1), CNTF(1), CNTFR(2), CRLF2(3), CSF1R(5), CSF2(2), CSF2RA(8), CSF2RB(6), CSF3R(3), CX3CL1(2), CX3CR1(3), CXCL1(1), CXCL13(1), CXCL6(1), CXCL9(1), CXCR4(2), CXCR6(1), EDA(2), EDA2R(1), EDAR(7), EGF(10), EPO(2), EPOR(1), FAS(1), FASLG(1), FLT1(10), FLT3(8), FLT4(8), GDF5(2), GH1(2), GH2(3), GHR(4), HGF(4), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), IFNK(1), IFNW1(3), IL10(1), IL10RB(1), IL12B(4), IL12RB1(4), IL12RB2(4), IL13RA1(3), IL15(2), IL15RA(1), IL17B(1), IL17RA(3), IL17RB(2), IL18(3), IL18R1(4), IL18RAP(9), IL19(1), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), IL1RAP(2), IL20(1), IL20RA(3), IL21R(3), IL22(2), IL22RA1(1), IL23A(1), IL23R(5), IL26(3), IL28B(1), IL28RA(1), IL2RB(2), IL3(2), IL3RA(4), IL4R(9), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(3), INHBA(1), INHBB(1), INHBE(3), KDR(14), KIT(9), KITLG(3), LEPR(3), LIFR(2), LTB(1), LTBR(2), MET(13), MPL(5), NGFR(1), OSM(1), OSMR(5), PDGFC(2), PDGFRB(4), PLEKHO2(1), PPBP(2), PRL(1), PRLR(2), RELT(4), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(4), TNFRSF11B(2), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF21(2), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(1), TNFRSF8(4), TNFRSF9(4), TNFSF10(2), TNFSF11(1), TNFSF13B(1), TNFSF14(7), TNFSF15(3), TNFSF18(1), TNFSF8(3), TNFSF9(5), TPO(10), VEGFA(4), VEGFB(3), VEGFC(3), XCL1(3), XCR1(1)	204511165	469	269	463	182	148	79	61	120	61	0	0.274	1.000	1.000
399	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	124	ABL1(6), ABLIM1(3), ABLIM2(2), ABLIM3(9), ARHGEF12(4), CFL1(1), CFL2(2), CXCR4(2), DCC(12), DPYSL5(2), EFNA1(1), EFNA3(4), EFNA5(3), EFNB1(3), EFNB2(2), EFNB3(2), EPHA1(4), EPHA2(2), EPHA3(10), EPHA4(8), EPHA5(9), EPHA6(5), EPHA7(8), EPHA8(10), EPHB1(4), EPHB2(5), EPHB3(1), EPHB4(6), EPHB6(10), FES(6), FYN(2), GNAI1(4), GNAI2(1), GNAI3(2), GSK3B(1), ITGB1(3), KRAS(5), L1CAM(12), LIMK1(4), LRRC4C(6), MAPK1(4), MAPK3(2), MET(13), NCK1(2), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NGEF(7), NRP1(5), NTN1(3), NTN4(5), NTNG1(2), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PLXNA1(11), PLXNA2(9), PLXNA3(7), PLXNB1(6), PLXNB2(3), PLXNB3(9), PLXNC1(3), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PTK2(2), RAC1(1), RAC2(1), RASA1(4), RGS3(11), RHOD(1), RND1(1), ROBO1(7), ROBO2(11), ROBO3(5), ROCK1(4), ROCK2(5), SEMA3A(5), SEMA3D(3), SEMA3F(2), SEMA4A(3), SEMA4B(2), SEMA4C(1), SEMA4D(3), SEMA4F(5), SEMA4G(3), SEMA5B(2), SEMA6A(3), SEMA6B(5), SEMA6C(2), SEMA6D(6), SEMA7A(4), SLIT1(6), SLIT2(8), SLIT3(11), SRGAP1(4), SRGAP2(5), SRGAP3(2), UNC5A(2), UNC5B(1), UNC5C(5), UNC5D(2)	230693750	468	256	461	159	135	78	65	123	66	1	0.0641	1.000	1.000
400	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTB(2), ACTG1(1), ACTN1(3), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(2), AMOTL1(5), ASH1L(5), CASK(2), CDK4(1), CGN(2), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSDA(1), CSNK2A1(3), CSNK2B(3), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTTN(3), EPB41(1), EPB41L1(2), EPB41L2(8), EPB41L3(12), EXOC3(1), EXOC4(3), F11R(2), GNAI1(4), GNAI2(1), GNAI3(2), HCLS1(4), INADL(7), JAM2(4), JAM3(2), KRAS(5), LLGL1(5), LLGL2(3), MAGI1(6), MAGI2(6), MAGI3(6), MLLT4(10), MPDZ(11), MRAS(1), MYH1(18), MYH10(8), MYH11(14), MYH13(19), MYH14(7), MYH15(10), MYH2(25), MYH3(11), MYH6(7), MYH7(13), MYH7B(12), MYH9(3), MYL2(2), MYL5(1), OCLN(3), PARD3(3), PARD6A(1), PARD6B(4), PPM1J(4), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PPP2R3A(5), PPP2R4(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCI(2), PRKCQ(4), RAB3B(1), RRAS(1), SPTAN1(8), SRC(2), SYMPK(6), TJAP1(3), TJP1(8), TJP2(1), TJP3(8), YES1(2), ZAK(2)	219634555	437	256	429	129	176	59	54	94	52	2	0.00361	1.000	1.000
401	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(3), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ARRB1(2), ARRB2(1), ATF1(1), ATF2(2), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(4), CACNB3(4), CALCA(2), CALM1(1), CALM3(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CNN2(2), CORIN(5), CREB3(3), DGKZ(2), FOS(2), GABPA(2), GBA2(1), GJA1(5), GNB1(1), GNB2(2), GNB3(1), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GNG5(1), GRK4(5), GRK5(4), GUCY1A3(3), IGFBP2(1), IGFBP6(1), IL1B(3), IL6(2), ITPR1(9), ITPR2(15), ITPR3(18), MIB1(5), MYL2(2), MYLK2(1), NFKB1(2), NOS1(10), NOS3(10), PDE4B(2), PDE4D(8), PKIB(1), PLCB3(4), PLCD1(4), PLCG1(12), PLCG2(12), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCH(4), PRKCQ(4), PRKD1(1), RAMP3(2), RGS1(1), RGS11(1), RGS14(1), RGS18(2), RGS19(1), RGS3(11), RGS4(4), RGS6(3), RGS7(3), RGS9(4), RLN1(1), RYR1(15), RYR2(58), RYR3(28), SFN(3), SLC8A1(3), SP1(1), TNXB(14), USP5(1), YWHAB(2), YWHAH(2), YWHAQ(1)	205983677	435	254	430	148	163	61	56	94	58	3	0.0302	1.000	1.000
402	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(3), CADM1(4), CADM3(1), CD2(1), CD22(10), CD226(1), CD274(1), CD276(2), CD28(2), CD34(1), CD4(2), CD40(1), CD40LG(2), CD58(2), CD6(2), CD86(3), CD8A(1), CDH1(4), CDH15(3), CDH2(2), CDH3(3), CDH4(8), CDH5(5), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(3), CNTN2(4), CNTNAP1(5), CNTNAP2(17), CTLA4(1), ESAM(1), F11R(2), GLG1(3), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(5), HLA-DOA(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(3), HLA-G(2), ICAM1(3), ICAM2(2), ICOS(1), ICOSLG(4), ITGA4(8), ITGA6(5), ITGA8(6), ITGA9(2), ITGAL(2), ITGAM(7), ITGAV(3), ITGB1(3), ITGB2(5), ITGB7(7), ITGB8(2), JAM2(4), JAM3(2), L1CAM(12), MAG(5), MPZ(2), MPZL1(2), NCAM1(4), NEGR1(5), NEO1(9), NFASC(2), NLGN1(4), NLGN2(4), NLGN3(5), NRCAM(8), NRXN1(10), NRXN2(1), NRXN3(8), OCLN(3), PDCD1(1), PDCD1LG2(1), PTPRC(9), PTPRF(10), PTPRM(10), PVR(3), PVRL1(3), PVRL2(1), PVRL3(2), SDC1(2), SDC2(1), SDC3(1), SDC4(1), SELE(8), SELP(4), SELPLG(3), SIGLEC1(6), SPN(1), VCAM1(2), VCAN(10)	175606064	378	228	372	149	135	65	37	88	53	0	0.281	1.000	1.000
403	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	36	ACTA2(3), ACTN2(6), ACTN3(1), ACTN4(2), DES(3), DMD(23), FAM48A(2), MYBPC1(4), MYBPC2(4), MYBPC3(1), MYH3(11), MYH6(7), MYH7(13), MYL1(2), MYL2(2), MYL3(1), MYOM1(5), NEB(26), TMOD1(1), TNNC2(1), TNNI1(1), TNNT1(4), TNNT2(1), TNNT3(4), TPM1(6), TPM2(1), TPM3(3), TPM4(1), TTN(226), VIM(2)	157584525	367	211	362	105	124	56	40	110	35	2	0.0210	1.000	1.000
404	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	160	ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(3), ADRB2(1), AGTR1(1), AGTR2(4), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), CCBP2(1), CCKAR(1), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CCR9(2), CHML(4), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(3), CXCR4(2), DRD1(1), DRD2(1), DRD3(3), EDNRA(1), EDNRB(1), F2R(2), F2RL1(4), F2RL3(3), FPR1(1), FSHR(3), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GPR17(2), GPR173(1), GPR174(2), GPR27(1), GPR35(2), GPR37(5), GPR37L1(1), GPR4(3), GPR50(3), GPR6(3), GPR63(1), GPR77(1), GPR83(4), GPR85(4), GPR87(1), GRPR(4), HCRTR1(1), HCRTR2(3), HRH1(3), HRH2(3), HRH3(3), HTR1A(2), HTR1B(2), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), LHCGR(2), LTB4R(1), MC1R(3), MC3R(6), MC4R(6), MC5R(5), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(6), NMUR1(4), NMUR2(6), NPY1R(3), NPY2R(2), NPY5R(3), NTSR1(4), OPN1SW(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), OR10A5(2), OR11A1(1), OR1C1(4), OR1F1(2), OR1Q1(1), OR2H1(3), OR5V1(3), OR7A5(1), OR7C1(2), P2RY1(1), P2RY10(1), P2RY12(2), P2RY13(1), P2RY2(3), P2RY6(2), PPYR1(1), PTAFR(2), PTGER4(2), PTGFR(7), RGR(1), RRH(1), SSTR2(3), SSTR3(6), SUCNR1(3), TBXA2R(1), TRHR(2)	142492957	328	203	323	137	154	49	37	68	20	0	0.115	1.000	1.000
405	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ADK(1), ADSL(4), ADSSL1(1), AK1(1), AK5(3), AK7(9), ALLC(6), AMPD1(8), AMPD2(4), AMPD3(2), ATIC(1), CANT1(4), DCK(2), ENPP1(5), ENPP3(2), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), FHIT(1), GART(4), GDA(2), GMPR(1), GMPR2(3), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HPRT1(1), IMPDH1(5), IMPDH2(1), NME7(2), NPR1(2), NPR2(3), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(3), NT5M(1), NUDT2(1), PAICS(2), PDE10A(2), PDE11A(6), PDE1A(3), PDE1C(9), PDE2A(5), PDE3B(3), PDE4A(3), PDE4B(2), PDE4C(3), PDE4D(8), PDE5A(1), PDE7A(2), PDE7B(2), PDE8A(7), PDE8B(2), PDE9A(2), PFAS(7), PKLR(4), PNPT1(1), POLA1(3), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1), PPAT(2), PRIM1(2), PRIM2(2), PRPS1(1), PRPS1L1(3), PRPS2(5), RRM1(3), RRM2(1), RRM2B(1), XDH(11)	194199771	333	200	331	108	108	63	35	82	45	0	0.0452	1.000	1.000
406	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	147	AKT1(2), CBL(2), CBLB(3), CBLC(2), CCND1(4), CCND2(2), CCND3(1), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(13), CRLF2(3), CSF2(2), CSF2RA(8), CSF2RB(6), CSF3R(3), EP300(6), EPO(2), EPOR(1), GH1(2), GH2(3), GHR(4), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), IFNK(1), IFNW1(3), IL10(1), IL10RB(1), IL12B(4), IL12RB1(4), IL12RB2(4), IL13RA1(3), IL13RA2(1), IL15(2), IL15RA(1), IL19(1), IL20(1), IL20RA(3), IL21R(3), IL22(2), IL22RA1(1), IL23A(1), IL23R(5), IL26(3), IL28B(1), IL28RA(1), IL2RB(2), IL3(2), IL3RA(4), IL4R(9), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(3), IRF9(8), JAK1(3), JAK2(5), JAK3(5), LEPR(3), LIFR(2), MPL(5), OSM(1), OSMR(5), PIAS1(2), PIAS3(3), PIAS4(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIM1(3), PRL(1), PRLR(2), PTPN6(1), SOCS1(1), SOCS4(3), SOCS5(2), SOS1(7), SOS2(5), SPRED1(1), SPRED2(3), SPRY1(1), SPRY2(3), SPRY3(3), SPRY4(3), STAM(2), STAM2(2), STAT1(4), STAT2(2), STAT3(3), STAT4(4), STAT5A(1), STAT5B(2), STAT6(5), TPO(10), TYK2(10)	166227050	337	197	336	105	99	51	43	101	42	1	0.0450	1.000	1.000
407	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	126	ACACA(17), ACACB(18), AKT1(2), ARAF(1), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CBL(2), CBLB(3), CBLC(2), CRKL(2), ELK1(5), EXOC7(3), FASN(3), FBP1(3), FBP2(2), FLOT1(2), FLOT2(3), FOXO1(1), G6PC2(1), GCK(2), GSK3B(1), GYS1(1), GYS2(2), IKBKB(2), INPP5D(5), INSR(6), IRS1(8), IRS2(1), IRS4(7), KRAS(5), LIPE(3), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(2), MKNK1(2), PCK1(6), PDE3A(5), PDE3B(3), PFKL(5), PFKP(1), PHKA1(5), PHKA2(5), PHKB(1), PHKG1(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PKLR(4), PPARGC1A(1), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R3A(13), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(2), PRKAG3(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCI(2), PRKX(1), PTPN1(1), PTPRF(10), PYGB(3), PYGL(6), PYGM(2), RAF1(2), RAPGEF1(4), RHOQ(1), RPS6KB1(2), RPS6KB2(3), SH2B2(2), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS1(1), SOCS4(3), SORBS1(3), SOS1(7), SOS2(5), SREBF1(7), TRIP10(1), TSC1(2), TSC2(6)	183166788	315	192	313	116	97	54	34	89	38	3	0.285	1.000	1.000
408	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	88	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), CSNK1D(2), DRD1(1), DRD2(1), EGF(10), GJA1(5), GJD2(3), GNA11(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAS(4), GRM1(7), GRM5(6), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HTR2A(2), HTR2B(2), HTR2C(4), ITPR1(9), ITPR2(15), ITPR3(18), KRAS(5), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAPK1(4), MAPK3(2), MAPK7(6), NPR1(2), NPR2(3), PDGFA(1), PDGFC(2), PDGFD(4), PDGFRB(4), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKG1(2), PRKG2(6), PRKX(1), RAF1(2), SOS1(7), SOS2(5), SRC(2), TJP1(8), TUBA1A(3), TUBA1B(1), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3)	149952446	280	189	277	99	101	44	33	56	43	3	0.146	1.000	1.000
409	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(3), APC2(3), AXIN1(4), AXIN2(2), BTRC(2), CACYBP(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CCND1(4), CCND2(2), CCND3(1), CHD8(11), CREBBP(13), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(3), CSNK2B(3), CTBP1(5), CTBP2(4), CTNNB1(3), CUL1(4), CXXC4(2), DAAM1(1), DAAM2(3), DKK1(2), DKK2(5), DKK4(2), DVL1(1), DVL2(3), DVL3(3), EP300(6), FBXW11(1), FZD1(3), FZD10(5), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GSK3B(1), LEF1(1), LRP5(7), LRP6(9), MAP3K7(3), MAPK10(1), MAPK8(2), MAPK9(2), MMP7(2), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NKD1(2), NKD2(4), NLK(1), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PORCN(8), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRICKLE1(2), PRICKLE2(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PSEN1(1), RAC1(1), RAC2(1), RBX1(1), ROCK1(4), ROCK2(5), RUVBL1(3), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(1), SIAH1(3), SMAD2(3), SMAD3(3), SMAD4(1), SOX17(4), TBL1X(1), TBL1XR1(3), TBL1Y(1), TCF7L2(5), VANGL1(2), VANGL2(2), WIF1(3), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2)	190586815	326	187	324	103	104	44	39	75	63	1	0.0549	1.000	1.000
410	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ATF4(1), CACNA1C(7), CACNA1D(11), CACNA1F(7), CACNA1S(14), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CGA(1), ELK1(5), GNA11(1), GNAS(4), GNRHR(3), HBEGF(1), ITPR1(9), ITPR2(15), ITPR3(18), KRAS(5), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAP3K3(2), MAP3K4(7), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK7(6), MAPK8(2), MAPK9(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLD1(8), PRKACG(1), PRKCA(6), PRKCD(3), PRKX(1), PTK2B(5), RAF1(2), SOS1(7), SOS2(5), SRC(2)	148024229	288	184	282	95	111	50	35	53	36	3	0.0217	1.000	1.000
411	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(3), ACTN2(6), ACTN3(1), ACTN4(2), ARHGAP5(5), BCAR1(3), CDH5(5), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTNND1(1), CXCR4(2), CYBA(1), CYBB(2), ESAM(1), EZR(4), F11R(2), GNAI1(4), GNAI2(1), GNAI3(2), ICAM1(3), ITGA4(8), ITGAL(2), ITGAM(7), ITGB1(3), ITGB2(5), ITK(1), JAM2(4), JAM3(2), MAPK12(2), MAPK13(2), MLLT4(10), MMP9(4), MSN(2), MYL2(2), MYL5(1), NCF1(3), NCF2(5), NCF4(1), NOX1(1), NOX3(5), OCLN(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PRKCA(6), PRKCG(4), PTK2(2), PTK2B(5), PXN(1), RAC1(1), RAC2(1), RAPGEF3(2), RAPGEF4(3), RASSF5(1), RHOH(1), ROCK1(4), ROCK2(5), SIPA1(3), TXK(2), VASP(1), VAV1(9), VAV2(4), VAV3(3), VCAM1(2), VCL(1)	141884777	274	179	271	123	102	37	32	67	35	1	0.846	1.000	1.000
412	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CALM1(1), CALM3(1), CALML3(1), CALML6(1), CDS2(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(2), INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPP5B(4), INPP5D(5), INPP5E(1), INPPL1(8), ITGB1BP3(1), ITPK1(3), ITPR1(9), ITPR2(15), ITPR3(18), OCRL(7), PI4KA(8), PI4KB(4), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3C3(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(5), PRKCA(6), PRKCG(4), PTPMT1(1), SYNJ1(6), SYNJ2(12)	142870190	287	178	285	85	99	49	31	67	39	2	0.0119	1.000	1.000
413	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	78	AGL(6), AMY2B(6), ASCC3(7), ATP13A2(3), DDX18(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(5), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(4), DHX58(2), ENPP1(5), ENPP3(2), ENTPD7(2), EP400(9), ERCC2(3), ERCC3(2), G6PC2(1), GAA(6), GANC(5), GBA(1), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(5), HK3(5), IFIH1(3), LYZL1(1), MGAM(15), MOV10L1(7), PGM1(1), PGM3(1), PYGB(3), PYGL(6), PYGM(2), RAD54B(5), RAD54L(6), RUVBL2(4), SETX(5), SI(11), SKIV2L2(3), SMARCA2(5), SMARCA5(3), TREH(2), UGDH(1), UGP2(1), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(9), UGT2B10(7), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), UXS1(4)	144922790	274	177	272	79	91	45	33	74	31	0	0.0274	1.000	1.000
414	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	120	ARAF(1), CD244(2), CSF2(2), FAS(1), FASLG(1), FCGR3A(1), FCGR3B(1), FYN(2), GZMB(3), HLA-A(1), HLA-C(1), HLA-E(1), HLA-G(2), ICAM1(3), ICAM2(2), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), ITGAL(2), ITGB2(5), KIR2DL1(6), KIR2DL3(2), KIR2DL4(1), KIR3DL1(1), KIR3DL2(5), KLRC1(3), KLRC2(5), KLRD1(1), KLRK1(1), KRAS(5), LAT(2), LCK(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MICA(4), MICB(2), NCR1(3), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PAK1(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRF1(3), PRKCA(6), PRKCG(4), PTK2B(5), PTPN6(1), RAC1(1), RAC2(1), RAF1(2), SH2D1A(3), SH2D1B(3), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), ULBP1(2), ULBP3(4), VAV1(9), VAV2(4), VAV3(3), ZAP70(8)	126261076	267	176	262	102	73	42	33	73	44	2	0.366	1.000	1.000
415	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(6), ANAPC1(3), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC4(2), ANAPC5(5), ANAPC7(2), ATM(12), ATR(10), BUB1(5), BUB1B(2), BUB3(3), CCNA1(3), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNH(2), CDC14A(2), CDC14B(5), CDC16(2), CDC20(1), CDC23(4), CDC25A(1), CDC25B(1), CDC27(5), CDC6(1), CDC7(2), CDK2(1), CDK4(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), CHEK1(6), CHEK2(3), CREBBP(13), CUL1(4), DBF4(6), E2F1(1), E2F2(1), E2F3(1), EP300(6), ESPL1(8), FZR1(4), GADD45B(1), GSK3B(1), HDAC2(7), MAD1L1(1), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), PKMYT1(1), PLK1(2), PRKDC(14), RBL1(6), RBL2(3), RBX1(1), SFN(3), SKP2(4), SMAD2(3), SMAD3(3), SMAD4(1), SMC1A(11), SMC1B(9), TFDP1(1), TGFB2(2), TGFB3(1), WEE1(2), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1)	158139080	290	169	289	77	45	56	44	88	54	3	0.0215	1.000	1.000
416	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ASIP(1), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CREB1(2), CREB3(3), CREB3L1(2), CREB3L2(1), CREB3L3(4), CREB3L4(1), CREBBP(13), CTNNB1(3), DCT(1), DVL1(1), DVL2(3), DVL3(3), EDNRB(1), EP300(6), FZD1(3), FZD10(5), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(4), GNAS(4), GSK3B(1), KIT(9), KITLG(3), KRAS(5), LEF1(1), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MC1R(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), RAF1(2), TCF7L2(5), TYR(5), TYRP1(6), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2)	128322321	245	169	240	76	87	30	32	51	43	2	0.0510	1.000	1.000
417	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(1), CACNA1A(4), GNA11(1), GNA13(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(4), GNAS(4), GNAZ(1), GRIA1(8), GRIA2(2), GRIA3(10), GRID2(5), GRM1(7), GRM5(6), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IGF1(3), IGF1R(10), ITPR1(9), ITPR2(15), ITPR3(18), KRAS(5), LYN(2), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), NOS1(10), NOS3(10), NPR1(2), NPR2(3), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PRKCA(6), PRKCG(4), PRKG1(2), PRKG2(6), RAF1(2), RYR1(15)	128937457	259	168	257	89	80	40	40	56	40	3	0.156	1.000	1.000
418	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(3), ACVR1B(3), ACVRL1(6), AKT1(2), AURKB(1), BMPR1A(1), BMPR2(1), BUB1(5), CDKL1(2), CDKL2(2), CDS2(2), CLK1(2), CLK2(1), CLK4(2), CSNK2A1(3), CSNK2B(3), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(2), INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPPL1(8), MAP3K10(1), NEK1(4), NEK3(4), OCRL(7), PAK4(3), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3CB(7), PIK3CG(12), PIM2(4), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCG1(12), PLCG2(12), PLK3(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCQ(4), PRKD1(1), PRKG1(2), RAF1(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), STK11(1), TGFBR1(4), VRK1(3)	131619165	251	168	248	80	77	42	33	56	40	3	0.114	1.000	1.000
419	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	65	A2M(7), BDKRB1(1), C1QA(2), C1QB(1), C1QC(1), C1R(2), C1S(5), C2(2), C3(19), C3AR1(3), C4BPA(6), C4BPB(2), C5(7), C5AR1(4), C6(4), C7(5), C8A(4), C8B(7), C9(2), CD46(5), CD55(2), CD59(1), CFB(7), CFD(1), CFI(1), CPB2(1), CR1(5), CR2(8), F10(2), F12(1), F13A1(5), F13B(5), F2(4), F2R(2), F5(13), F7(2), F8(24), FGA(12), FGB(4), FGG(6), KLKB1(7), KNG1(4), MASP1(2), MASP2(1), MBL2(4), PLAT(3), PLAU(1), PLG(6), PROS1(3), SERPINA1(2), SERPINA5(2), SERPINC1(2), SERPIND1(1), SERPINE1(4), SERPINF2(1), SERPING1(4), VWF(14)	103431174	256	164	254	80	83	46	32	61	34	0	0.0199	1.000	1.000
420	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(7), ABCA10(5), ABCA12(5), ABCA13(22), ABCA2(4), ABCA3(5), ABCA4(11), ABCA5(7), ABCA6(9), ABCA7(11), ABCA8(5), ABCA9(6), ABCB1(15), ABCB10(3), ABCB11(3), ABCB4(12), ABCB5(9), ABCB6(1), ABCB7(6), ABCB8(2), ABCB9(4), ABCC1(6), ABCC10(13), ABCC11(8), ABCC12(4), ABCC2(1), ABCC3(6), ABCC4(8), ABCC5(6), ABCC6(2), ABCC8(7), ABCC9(20), ABCD1(3), ABCD2(5), ABCD3(1), ABCG1(3), ABCG2(3), ABCG4(4), ABCG5(4), ABCG8(5), CFTR(6), TAP1(2), TAP2(4)	140615356	273	160	270	101	83	42	39	78	28	3	0.311	1.000	1.000
421	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(1), ACTB(2), ACTG1(1), ACTN1(3), ACTN2(6), ACTN3(1), ACTN4(2), ACVR1B(3), ACVR1C(3), BAIAP2(3), CDH1(4), CREBBP(13), CSNK2A1(3), CSNK2B(3), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTNND1(1), EP300(6), ERBB2(3), FARP2(2), FER(1), FGFR1(3), FYN(2), IGF1R(10), INSR(6), IQGAP1(9), LEF1(1), LMO7(8), MAP3K7(3), MAPK1(4), MAPK3(2), MET(13), MLLT4(10), NLK(1), PARD3(3), PTPN1(1), PTPN6(1), PTPRB(9), PTPRF(10), PTPRJ(5), PTPRM(10), PVRL1(3), PVRL2(1), PVRL3(2), PVRL4(4), RAC1(1), RAC2(1), SMAD2(3), SMAD3(3), SMAD4(1), SNAI2(2), SORBS1(3), SRC(2), SSX2IP(1), TCF7L2(5), TGFBR1(4), TGFBR2(5), TJP1(8), VCL(1), WAS(3), WASF1(1), WASF2(1), WASF3(4), WASL(2), YES1(2)	139055184	250	158	250	76	74	33	33	63	46	1	0.0459	1.000	1.000
422	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADK(1), ADSL(4), AK1(1), AK5(3), ALLC(6), AMPD1(8), AMPD2(4), AMPD3(2), ATIC(1), ATP1B1(1), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5I(1), CANT1(4), DCK(2), ENPP1(5), ENPP3(2), ENTPD1(3), FHIT(1), GART(4), GDA(2), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HPRT1(1), IMPDH1(5), IMPDH2(1), NPR1(2), NPR2(3), NT5C(3), NT5E(3), NT5M(1), NUDT2(1), PAICS(2), PDE1A(3), PDE4A(3), PDE4B(2), PDE4C(3), PDE4D(8), PDE5A(1), PDE6B(5), PDE6C(7), PDE7B(2), PDE8A(7), PDE9A(2), PFAS(7), PKLR(4), POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(3), PRPS2(5), RRM1(3), RRM2(1)	152547429	255	157	255	96	87	48	23	63	34	0	0.412	1.000	1.000
423	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(5), ADCY8(3), ARAF(1), ATF4(1), CACNA1C(7), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CAMK4(3), CREBBP(13), EP300(6), GRIA1(8), GRIA2(2), GRIN1(3), GRIN2A(17), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRM1(7), GRM5(6), ITPR1(9), ITPR2(15), ITPR3(18), KRAS(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), RAF1(2), RAPGEF3(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA6(5)	116329255	231	155	229	67	84	28	30	57	29	3	0.0103	1.000	1.000
424	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), BCAR1(3), CAPN1(2), CAPN10(4), CAPN11(6), CAPN3(3), CAPN5(2), CAPN6(3), CAPN7(1), CAPN9(4), CAPNS1(2), CAV3(1), CSK(2), DOCK1(3), FYN(2), ILK(1), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGA7(4), ITGA8(6), ITGA9(2), ITGAD(5), ITGAE(7), ITGAL(2), ITGAM(7), ITGAV(3), ITGAX(8), ITGB1(3), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAPK10(1), MAPK12(2), MAPK4(2), MAPK7(6), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PIK3R2(4), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAPGEF1(4), ROCK1(4), ROCK2(5), SDCCAG8(4), SEPP1(2), SHC1(1), SHC3(1), SORBS1(3), SOS1(7), SRC(2), TLN1(5), TNS1(6), VASP(1), VAV2(4), VAV3(3), VCL(1), ZYX(2)	159327918	253	155	252	91	85	39	31	65	33	0	0.237	1.000	1.000
425	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(5), CD14(1), CD19(2), CD1A(3), CD1B(5), CD1D(4), CD1E(6), CD2(1), CD22(10), CD33(6), CD34(1), CD36(5), CD37(1), CD38(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD44(6), CD5(2), CD55(2), CD59(1), CD7(3), CD8A(1), CR1(5), CR2(8), CSF1R(5), CSF2(2), CSF2RA(8), CSF3R(3), DNTT(3), EPO(2), EPOR(1), FCER2(1), FCGR1A(1), FLT3(8), GP5(2), GP9(1), GYPA(1), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), IL3(2), IL3RA(4), IL4R(9), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL7(1), IL7R(3), IL9R(3), ITGA1(4), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGAM(7), ITGB3(4), KIT(9), KITLG(3), MME(3), MS4A1(3), TFRC(2), THPO(2), TNF(1), TPO(10)	96874832	241	154	240	78	85	42	27	55	32	0	0.0278	1.000	1.000
426	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), AKAP1(2), AKAP11(3), AKAP12(1), AKAP3(2), AKAP4(8), AKAP5(3), AKAP6(12), AKAP7(2), AKAP8(5), AKAP9(15), ARHGEF1(1), CALM1(1), CALM3(1), GNA11(1), GNA13(1), GNA14(3), GNA15(1), GNAI2(1), GNAI3(2), GNAL(1), GNAO1(4), GNAZ(1), GNB1(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GNG5(1), GNGT2(1), ITPR1(9), KCNJ3(2), KRAS(5), PALM2(1), PDE1A(3), PDE1B(2), PDE1C(9), PDE4A(3), PDE4B(2), PDE4C(3), PDE4D(8), PDE7A(2), PDE7B(2), PDE8A(7), PDE8B(2), PLCB3(4), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCI(2), PRKCQ(4), PRKD1(1), PRKD3(2), RRAS(1), USP5(1)	138633952	229	152	226	75	69	40	24	51	43	2	0.116	1.000	1.000
427	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(6), ACTN1(3), ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), ARHGEF6(7), ARHGEF7(2), BCAR1(3), CDKN2A(6), CSE1L(1), DOCK1(3), EPHB2(5), FYN(2), GRB7(8), ILK(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGA7(4), ITGA8(6), ITGA9(2), MAP3K11(1), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2), MRAS(1), MYLK(7), MYLK2(1), P4HB(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PIK3CB(7), PKLR(4), PLCG1(12), PLCG2(12), PTK2(2), RAF1(2), RALA(2), ROCK1(4), ROCK2(5), SHC1(1), SOS1(7), SOS2(5), SRC(2), TERF2IP(1), TLN1(5), TLN2(8), VASP(1), WAS(3), ZYX(2)	139954910	238	147	232	71	66	39	32	65	36	0	0.0329	1.000	1.000
428	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG1(1), ALG10B(3), ALG12(2), ALG13(4), ALG14(1), ALG3(4), ALG6(3), B3GNT2(1), B3GNT7(2), B4GALT2(1), C1GALT1(1), CHPF(1), CHST1(2), CHST11(3), CHST13(3), CHST2(2), CHST3(3), CHST4(2), CHST6(2), CHSY1(4), DAD1(1), DPAGT1(2), EXT1(3), EXT2(3), EXTL1(4), EXTL2(2), EXTL3(1), FUT8(7), GALNT1(5), GALNT10(1), GALNT11(3), GALNT12(3), GALNT13(4), GALNT14(7), GALNT2(3), GALNT3(1), GALNT4(1), GALNT5(5), GALNT6(4), GALNT7(1), GALNT8(1), GALNT9(4), GALNTL1(1), GALNTL4(1), GALNTL5(1), GANAB(5), GCNT1(2), GCNT3(2), GCNT4(3), HS3ST1(3), HS3ST3A1(3), HS6ST2(4), HS6ST3(1), MAN1A1(3), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), MGAT5B(3), NDST1(2), NDST2(2), NDST3(4), NDST4(8), OGT(9), RPN1(1), RPN2(1), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST6GAL1(2), ST6GALNAC1(2), STT3B(2), UST(1), WBSCR17(11), XYLT1(3), XYLT2(3)	131029842	223	146	221	77	82	39	29	44	29	0	0.156	1.000	1.000
429	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(2), CARD11(8), CBL(2), CBLB(3), CBLC(2), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD40LG(2), CD8A(1), CDK4(1), CHUK(1), CSF2(2), CTLA4(1), FOS(2), FYN(2), GRAP2(2), ICOS(1), IFNG(2), IKBKB(2), IL10(1), IL5(1), ITK(1), KRAS(5), LAT(2), LCK(1), LCP2(1), MALT1(4), MAP3K8(4), NCK1(2), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PDCD1(1), PDK1(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKCQ(4), PTPN6(1), PTPRC(9), RASGRP1(2), SOS1(7), SOS2(5), TEC(4), TNF(1), VAV1(9), VAV2(4), VAV3(3), ZAP70(8)	115644535	223	140	217	75	65	42	26	57	32	1	0.173	1.000	1.000
430	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	79	ABL1(6), ABL2(3), AKT1(2), ARAF(1), AREG(3), BTC(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CBL(2), CBLB(3), CBLC(2), CDKN1A(2), CDKN1B(4), CRKL(2), EGF(10), ELK1(5), ERBB2(3), ERBB3(4), ERBB4(5), EREG(1), GSK3B(1), HBEGF(1), KRAS(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(2), NCK1(2), NRG1(5), NRG2(1), NRG4(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PRKCA(6), PRKCG(4), PTK2(2), RAF1(2), RPS6KB1(2), RPS6KB2(3), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), SRC(2), STAT5A(1), STAT5B(2)	112339055	211	138	206	61	58	34	28	53	36	2	0.0373	1.000	1.000
431	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(5), ASH2L(2), CARM1(1), CTCFL(4), DOT1L(4), EHMT1(5), EHMT2(5), EZH1(2), EZH2(5), FBXO11(2), HCFC1(8), HSF4(2), JMJD4(2), JMJD6(4), KDM6A(6), MEN1(4), MLL(3), MLL2(10), MLL3(10), MLL5(1), NSD1(5), OGT(9), PAXIP1(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PRDM2(6), PRDM7(3), PRDM9(18), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), RBBP5(3), SATB1(3), SETD1A(4), SETD2(15), SETD7(2), SETD8(1), SETDB1(8), SETDB2(1), SETMAR(5), SMYD3(2), STK38(1), SUV39H1(2), SUV39H2(1), SUV420H1(3), SUZ12(2), WHSC1L1(4)	141487274	200	135	199	52	50	33	27	56	34	0	0.0414	1.000	1.000
432	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	95	AKT1(2), CASP8(2), CCL3(1), CCL5(1), CD14(1), CD40(1), CD86(3), CHUK(1), CXCL9(1), FOS(2), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IKBKB(2), IKBKE(5), IL12B(4), IL1B(3), IL6(2), IRAK1(3), IRAK4(2), IRF3(3), IRF5(2), IRF7(3), LBP(5), LY96(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K7(3), MAP3K8(4), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK9(2), NFKB1(2), NFKB2(2), NFKBIA(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), RAC1(1), RELA(1), RIPK1(4), SPP1(2), STAT1(4), TBK1(2), TICAM1(1), TLR1(6), TLR2(5), TLR3(6), TLR4(2), TLR5(4), TLR6(8), TLR7(10), TLR8(1), TLR9(5), TNF(1), TOLLIP(1), TRAF3(1)	101655710	198	135	195	73	62	41	22	45	26	2	0.190	1.000	1.000
433	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(3), ACVR1B(3), ACVR1C(3), ACVR2A(2), ACVRL1(6), AMHR2(2), BMP2(1), BMP4(3), BMP5(8), BMP6(3), BMPR1A(1), BMPR1B(1), BMPR2(1), CDKN2B(2), CHRD(2), COMP(1), CREBBP(13), CUL1(4), DCN(3), E2F4(1), E2F5(1), EP300(6), FST(1), GDF5(2), GDF6(2), GDF7(2), ID1(1), IFNG(2), INHBA(1), INHBB(1), INHBE(3), LEFTY2(4), LTBP1(7), MAPK1(4), MAPK3(2), NODAL(1), PITX2(7), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), RBL1(6), RBL2(3), RBX1(1), ROCK1(4), ROCK2(5), RPS6KB1(2), RPS6KB2(3), SMAD1(4), SMAD2(3), SMAD3(3), SMAD4(1), SMAD5(1), SMAD6(1), SMAD7(3), SMAD9(3), SMURF1(4), SMURF2(2), SP1(1), TFDP1(1), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNF(1), ZFYVE16(2), ZFYVE9(2)	117902449	214	128	214	56	60	34	33	55	31	1	0.00692	1.000	1.000
434	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(6), ATM(12), BUB1(5), BUB1B(2), BUB3(3), CCNA1(3), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNH(2), CDAN1(5), CDC14A(2), CDC14B(5), CDC20(1), CDC25A(1), CDC25B(1), CDC6(1), CDC7(2), CDH1(4), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(6), CHEK1(6), CHEK2(3), DTX4(4), E2F1(1), E2F2(1), E2F3(1), E2F4(1), E2F5(1), E2F6(1), EP300(6), ESPL1(8), GSK3B(1), HDAC2(7), HDAC3(1), HDAC4(4), HDAC5(1), HDAC6(4), MAD1L1(1), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), MPEG1(3), MPL(5), PLK1(2), PRKDC(14), PTPRA(7), RBL1(6), SKP2(4), SMAD4(1), TBC1D8(4), TFDP1(1), WEE1(2)	127600580	212	125	211	68	44	42	24	62	37	3	0.234	1.000	1.000
435	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1C1(1), AKR1C2(1), AKR1C3(2), AKR1C4(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), CYP1A2(4), CYP1B1(2), CYP2B6(6), CYP2C18(3), CYP2C19(6), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP2S1(2), CYP3A4(5), CYP3A43(1), CYP3A7(6), EPHX1(4), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(3), GSTA5(4), GSTK1(2), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(9), UGT2B10(7), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4)	66803619	176	123	174	56	59	22	23	55	17	0	0.131	1.000	1.000
436	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(2), CHUK(1), CREB1(2), DAXX(5), ELK1(5), FOS(2), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP2K5(2), MAP3K1(9), MAP3K10(1), MAP3K11(1), MAP3K12(6), MAP3K13(3), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K6(1), MAP3K7(3), MAP3K8(4), MAP3K9(6), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(4), MAP4K5(1), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK4(2), MAPK7(6), MAPK8(2), MAPK9(2), MAPKAPK2(2), MAPKAPK3(2), MAPKAPK5(2), MEF2A(4), MEF2B(1), MEF2D(1), MKNK1(2), NFKB1(2), NFKBIA(3), PAK1(3), PAK2(2), RAC1(1), RAF1(2), RELA(1), RIPK1(4), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA5(2), RPS6KB1(2), RPS6KB2(3), SHC1(1), SP1(1), STAT1(4), TGFB2(2), TGFB3(1), TGFBR1(4), TRADD(1), TRAF2(2)	110813558	182	121	179	60	49	31	29	35	36	2	0.174	1.000	1.000
437	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(2), CLK2(1), CLK3(3), CLK4(2), COL2A1(7), CPSF1(6), CPSF2(2), CPSF3(3), CSTF1(3), CSTF2(4), CSTF3(4), DDIT3(2), DDX20(1), DHX15(1), DHX16(4), DHX38(4), DHX8(8), DHX9(2), DICER1(7), FUS(4), LOC440563(2), METTL3(4), NCBP1(1), NCBP2(1), NONO(4), NUDT21(1), NXF1(1), PAPOLA(7), PHF5A(3), POLR2A(9), PRPF18(1), PRPF4(2), PRPF4B(4), PRPF8(12), PSKH1(1), PTBP1(3), RNGTT(4), SF3A1(2), SF3A2(1), SF3A3(2), SF3B1(8), SF3B2(2), SF3B4(1), SNRPA(1), SNRPB(2), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPE(1), SNRPF(1), SNURF(2), SPOP(4), SRPK1(3), SRPK2(2), SRRM1(3), SUPT5H(2), TXNL4A(1), U2AF1(3), U2AF2(3), XRN2(3)	125614794	181	118	180	43	56	26	23	46	29	1	0.0301	1.000	1.000
438	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(2), BCL2(3), CABIN1(11), CALM1(1), CALM3(1), CAMK4(3), CD3E(2), CD3G(1), CDKN1A(2), CEBPB(2), CNR1(1), CREBBP(13), CSF2(2), CSNK2A1(3), CSNK2B(3), CTLA4(1), EGR2(2), EGR3(2), EP300(6), FCER1A(4), FCGR3A(1), FOS(2), GATA3(3), GATA4(3), GSK3B(1), ICOS(1), IFNB1(2), IFNG(2), IL10(1), IL1B(3), IL3(2), IL6(2), ITK(1), KPNA5(4), MAPK8(2), MAPK9(2), MEF2A(4), MEF2B(1), MEF2D(1), MYF5(6), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB2(2), NFKBIE(3), NUP214(4), OPRD1(2), P2RX7(1), PAK1(3), PPP3CB(2), PPP3CC(1), PTPRC(9), RELA(1), RPL13A(2), SFN(3), SLA(2), SP1(1), SP3(5), TNF(1), TRAF2(2), VAV1(9), VAV2(4), VAV3(3), XPO5(1)	106320846	189	117	188	59	47	41	20	48	33	0	0.0595	1.000	1.000
439	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	71	AKT1(2), BTK(3), CSF2(2), FCER1A(4), FYN(2), GAB2(3), IL3(2), IL5(1), INPP5D(5), KRAS(5), LAT(2), LCP2(1), LYN(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK9(2), PDK1(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCG1(12), PLCG2(12), PRKCA(6), PRKCD(3), PRKCE(1), RAC1(1), RAC2(1), RAF1(2), SOS1(7), SOS2(5), TNF(1), VAV1(9), VAV2(4), VAV3(3)	80812100	177	117	172	57	54	33	24	41	23	2	0.0988	1.000	1.000
440	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(1), AGTR2(4), ATP8A1(5), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), CCKAR(1), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CX3CR1(3), CXCR4(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(3), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GNRHR(3), GPR77(1), GRPR(4), LHCGR(2), MC1R(3), MC2R(2), MC3R(6), MC4R(6), MC5R(5), NMBR(6), NPY1R(3), NPY2R(2), NPY5R(3), NTSR1(4), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), PPYR1(1), SSTR2(3), SSTR3(6), TACR2(2), TACR3(7), TRHR(2), TSHR(5)	61294334	154	117	154	70	69	20	24	34	7	0	0.509	1.000	1.000
441	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(2), CALM1(1), CALM3(1), CHRM1(3), CHRNA1(4), FLT1(10), FLT4(8), KDR(14), NOS3(10), PDE2A(5), PDE3A(5), PDE3B(3), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKG1(2), PRKG2(6), RYR2(58), SLC7A1(3), SYT1(2), TNNI1(1)	48217166	143	116	142	43	53	24	26	26	14	0	0.0274	1.000	1.000
442	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(2), CASP9(1), KDR(14), KRAS(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK12(2), MAPK13(2), MAPK3(2), MAPKAPK2(2), MAPKAPK3(2), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NOS3(10), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCG1(12), PLCG2(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKCA(6), PRKCG(4), PTGS2(3), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), SH2D2A(1), SHC2(1), SRC(2), VEGFA(4)	80766640	175	114	171	55	54	31	22	42	24	2	0.0360	1.000	1.000
443	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), ALG6(3), CCKBR(3), CCR2(2), CCR3(2), CCR5(1), CELSR1(13), CELSR2(14), CELSR3(17), CHRM2(3), CHRM3(4), EDNRA(1), EMR2(6), EMR3(2), F2R(2), FSHR(3), GHRHR(3), GNRHR(3), GPR116(12), GPR132(7), GPR133(7), GPR143(6), GPR17(2), GPR18(2), GPR61(4), GPR77(1), GPR84(2), GRM1(7), GRPR(4), HRH4(2), LGR6(1), LPHN2(8), LPHN3(7), LTB4R2(1), NTSR1(4), OR2M4(2), OR8G2(1), P2RY13(1), PTGFR(7), SMO(3), SSTR2(3), TAAR5(1), TSHR(5)	79258567	184	113	182	77	73	31	23	44	13	0	0.408	1.000	1.000
444	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(2), BCL2(3), BCR(3), BLNK(2), BTK(3), CD19(2), CD22(10), CD81(2), CR2(8), CSK(2), DAG1(3), FLOT1(2), FLOT2(3), GSK3B(1), INPP5D(5), ITPR1(9), ITPR2(15), ITPR3(18), LYN(2), MAP4K1(3), MAPK1(4), MAPK3(2), NFATC1(2), NFATC2(7), NR0B2(1), PDK1(2), PIK3CD(3), PLCG2(12), PPP1R13B(1), PPP3CA(1), PPP3CB(2), PPP3CC(1), PTPRC(9), RAF1(2), SHC1(1), SOS1(7), SOS2(5), VAV1(9)	83451435	169	111	169	54	59	28	18	42	20	2	0.0606	1.000	1.000
445	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(6), AKT1(2), APAF1(3), ATM(12), BAX(1), BCL2(3), BIRC2(3), BIRC3(1), CAPN1(2), CASP10(2), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CSF2RB(6), CYCS(2), DFFA(2), FAS(1), FASLG(1), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1RAP(2), IL3(2), IL3RA(4), IRAK1(3), IRAK2(3), IRAK3(9), IRAK4(2), NFKB1(2), NFKB2(2), NFKBIA(3), NTRK1(4), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RELA(1), RIPK1(4), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(2), TRADD(1), TRAF2(2)	93891892	154	110	153	54	39	26	17	45	27	0	0.461	1.000	1.000
446	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPP5B(4), INPP5E(1), INPPL1(8), IPMK(2), ISYNA1(2), ITGB1BP3(1), ITPK1(3), MINPP1(1), MIOX(1), OCRL(7), PI4KA(8), PI4KB(4), PIK3C3(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(5), PTPMT1(1), SYNJ1(6), SYNJ2(12)	84788221	169	107	167	54	50	29	17	48	25	0	0.187	1.000	1.000
447	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	58	AKT1(2), BLNK(2), BTK(3), CARD11(8), CD19(2), CD22(10), CD72(3), CD79A(1), CD81(2), CHUK(1), CR2(8), FOS(2), GSK3B(1), IFITM1(2), IKBKB(2), INPP5D(5), KRAS(5), LYN(2), MALT1(4), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG2(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PTPN6(1), RAC1(1), RAC2(1), RASGRP3(2), VAV1(9), VAV2(4), VAV3(3)	82384885	164	107	162	67	59	35	8	39	23	0	0.456	1.000	1.000
448	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(6), ADCY6(2), ADCY8(3), CACNA1A(4), CACNA1B(15), GNAS(4), GNAT3(5), GNB1(1), GNB3(1), GRM4(6), ITPR3(18), KCNB1(5), PDE1A(3), PLCB2(7), PRKACG(1), PRKX(1), SCNN1A(1), SCNN1B(6), SCNN1G(6), TAS1R1(2), TAS1R2(5), TAS1R3(1), TAS2R1(5), TAS2R10(3), TAS2R13(1), TAS2R16(5), TAS2R3(1), TAS2R38(1), TAS2R39(1), TAS2R4(2), TAS2R40(2), TAS2R41(5), TAS2R42(1), TAS2R46(1), TAS2R5(2), TAS2R60(1), TAS2R7(1), TAS2R9(4), TRPM5(4)	67850887	143	107	142	54	62	21	15	28	17	0	0.348	1.000	1.000
449	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(18), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ADIPOR1(2), ADIPOR2(3), AGRP(1), AKT1(2), CAMKK1(2), CAMKK2(2), CD36(5), CHUK(1), CPT1A(2), CPT1C(2), CPT2(2), G6PC2(1), IKBKB(2), IRS1(8), IRS2(1), IRS4(7), JAK1(3), JAK2(5), JAK3(5), LEPR(3), MAPK10(1), MAPK8(2), MAPK9(2), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), NPY(3), PCK1(6), PPARA(4), PPARGC1A(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(2), PRKAG3(2), PRKCQ(4), RELA(1), RXRA(4), RXRB(1), RXRG(3), SLC2A1(4), SLC2A4(1), STAT3(3), STK11(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2), TYK2(10)	96279906	172	107	172	67	55	32	9	46	29	1	0.466	1.000	1.000
450	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(3), ATM(12), ATR(10), BAI1(4), BAX(1), CASP8(2), CASP9(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNG1(2), CCNG2(2), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(6), CHEK1(6), CHEK2(3), CYCS(2), DDB2(3), EI24(4), FAS(1), GADD45B(1), GTSE1(5), IGF1(3), MDM2(5), MDM4(2), PPM1D(4), RCHY1(1), RFWD2(4), RPRM(1), RRM2(1), RRM2B(1), SERPINB5(3), SERPINE1(4), SESN1(2), SESN2(1), SESN3(2), SFN(3), SIAH1(3), STEAP3(2), THBS1(6), TP53I3(1), TSC2(6), ZMAT3(3)	75582767	150	106	148	41	27	23	28	42	30	0	0.0718	1.000	1.000
451	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	APH1A(2), CREBBP(13), CTBP1(5), CTBP2(4), DLL1(1), DLL3(1), DTX1(4), DTX2(1), DTX3L(2), DTX4(4), DVL1(1), DVL2(3), DVL3(3), EP300(6), HDAC2(7), HES1(1), JAG1(7), JAG2(5), LFNG(3), MAML1(6), MAML2(2), MAML3(4), MFNG(1), NCOR2(9), NCSTN(5), NOTCH2(16), NOTCH3(7), NOTCH4(10), NUMB(1), NUMBL(2), PSEN1(1), RBPJ(7), RBPJL(5), SNW1(3)	77662947	152	103	150	52	41	23	19	28	40	1	0.464	1.000	1.000
452	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADL(1), ACADM(2), ACOX1(2), ACOX2(3), ACOX3(3), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ANGPTL4(1), APOA1(1), APOA5(1), AQP7(4), CD36(5), CPT1A(2), CPT1C(2), CPT2(2), CYP27A1(2), CYP4A11(5), CYP4A22(2), CYP7A1(3), CYP8B1(3), DBI(1), EHHADH(2), FABP1(1), FABP4(1), FABP6(2), FABP7(1), FADS2(2), GK(3), GK2(5), HMGCS2(3), ILK(1), LPL(2), ME1(2), MMP1(3), NR1H3(5), OLR1(2), PCK1(6), PLTP(1), PPARA(4), PPARG(3), RXRA(4), RXRB(1), RXRG(3), SCD(1), SCP2(1), SLC27A1(4), SLC27A2(8), SLC27A4(1), SLC27A5(4), SLC27A6(4), SORBS1(3), UBC(8)	77675011	153	101	150	54	47	28	17	41	20	0	0.234	1.000	1.000
453	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(12), CCNA1(3), CCNB1(2), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNG2(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), CREB3(3), CREB3L1(2), CREB3L3(4), CREB3L4(1), E2F1(1), E2F2(1), E2F3(1), E2F4(1), E2F5(1), E2F6(1), GBA2(1), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), MYT1(7), NACA(6), POLA2(2), POLE(8), POLE2(1), PRIM1(2), RBL1(6), RPA1(3), RPA2(1), TFDP1(1), TNXB(14), WEE1(2)	88206123	149	99	148	42	26	17	21	44	41	0	0.171	1.000	1.000
454	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(2), AKR1D1(1), ARSD(3), ARSE(6), CARM1(1), CYP11B1(3), CYP11B2(3), CYP19A1(2), HSD11B1(2), HSD17B3(1), HSD17B7(2), HSD17B8(1), HSD3B1(2), HSD3B2(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SRD5A1(2), SRD5A2(1), STS(2), SULT2A1(2), SULT2B1(3), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(9), UGT2B10(7), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), WBSCR22(3)	58410403	136	98	133	47	40	20	22	42	12	0	0.231	1.000	1.000
455	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(3), BMP5(8), BMP6(3), BTRC(2), CSNK1A1(2), CSNK1A1L(2), CSNK1D(2), CSNK1E(1), CSNK1G1(2), CSNK1G2(2), CSNK1G3(1), DHH(1), FBXW11(1), GLI1(6), GLI2(5), GLI3(6), GSK3B(1), HHIP(3), IHH(3), LRP2(37), PRKACG(1), PRKX(1), PTCH1(3), PTCH2(2), RAB23(2), SHH(3), SMO(3), STK36(2), SUFU(4), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2), ZIC2(1)	71563786	139	98	138	43	57	22	18	24	18	0	0.0816	1.000	1.000
456	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(2), CDK2(1), CDKN1B(4), CDKN2A(6), CREB1(2), CREB3(3), ERBB4(5), GSK3B(1), IGF1(3), INPPL1(8), IRS1(8), IRS2(1), IRS4(7), MET(13), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PARD3(3), PARD6A(1), PDK1(2), PIK3CD(3), PPP1R13B(1), PREX1(10), PTK2(2), PTPN1(1), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SLC2A4(1), SOS1(7), SOS2(5), TSC1(2), TSC2(6), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1)	88165016	157	98	155	40	33	21	28	44	31	0	0.0372	1.000	1.000
457	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ABP1(4), ACAT2(1), ACMSD(2), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), AOC2(1), AOX1(9), ASMT(2), CAT(3), CYP19A1(2), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(6), CYP2C18(3), CYP2C19(6), CYP2C8(4), CYP2C9(3), CYP2D6(2), CYP2E1(2), CYP2F1(1), CYP3A4(5), CYP3A7(6), CYP4B1(5), CYP4F8(3), CYP51A1(2), DDC(5), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), KMO(4), KYNU(2), MAOA(3), MAOB(2), SDS(1), TDO2(2), TPH1(5), WARS(1), WARS2(2)	65351752	137	98	134	46	62	17	11	30	17	0	0.174	1.000	1.000
458	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(4), CAD(8), CANT1(4), CDA(3), CTPS2(2), DCK(2), DCTD(1), DHODH(2), DPYD(6), DPYS(5), DTYMK(1), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), NME7(2), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(3), NT5M(1), NUDT2(1), PNPT1(1), POLA1(3), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1), PRIM1(2), PRIM2(2), RRM1(3), RRM2(1), RRM2B(1), TK2(3), TXNRD1(1), TXNRD2(6), UCK1(4), UMPS(1), UPP1(3), UPP2(3), UPRT(2)	96254638	156	96	155	47	33	28	21	50	24	0	0.171	1.000	1.000
459	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	63	ADAM10(4), ATP6AP1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), CCL5(1), CHUK(1), CSK(2), CXCL1(1), F11R(2), GIT1(2), HBEGF(1), IKBKB(2), JAM2(4), JAM3(2), LYN(2), MAPK10(1), MAPK12(2), MAPK13(2), MAPK8(2), MAPK9(2), MET(13), NFKB1(2), NFKB2(2), NFKBIA(3), NOD1(3), PAK1(3), PLCG1(12), PLCG2(12), PTPRZ1(15), RAC1(1), RELA(1), SRC(2), TCIRG1(2), TJP1(8)	78837630	140	93	137	41	35	24	21	30	29	1	0.0754	1.000	1.000
460	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), ARHGAP1(1), ARHGAP4(4), ARHGEF11(4), BTK(3), CFL1(1), CFL2(2), GDI1(4), GDI2(1), INPPL1(8), ITPR1(9), ITPR2(15), ITPR3(18), LIMK1(4), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PDK1(2), PIK3CD(3), PIK3CG(12), PITX2(7), PPP1R13B(1), ROCK1(4), ROCK2(5), RPS4X(3), SAG(2), WASF1(1), WASL(2)	78081680	151	92	149	46	47	32	22	32	17	1	0.0529	1.000	1.000
461	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(2), BCR(3), BTK(3), CD19(2), CDKN2A(6), FLOT1(2), FLOT2(3), ITPR1(9), ITPR2(15), ITPR3(18), LYN(2), NR0B2(1), PDK1(2), PHF11(1), PITX2(7), PLCG2(12), PPP1R13B(1), PREX1(10), PTPRC(9), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SAG(2), TEC(4), VAV1(9)	62133992	139	92	138	43	46	24	18	32	18	1	0.0611	1.000	1.000
462	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAD(2), ALAS1(2), ALAS2(1), BLVRA(2), COX10(5), COX15(1), CP(7), EARS2(1), EPRS(5), FECH(2), FTH1(3), FTMT(4), GUSB(3), HCCS(5), HMBS(1), HMOX1(1), MMAB(3), PPOX(2), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(9), UGT2B10(7), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), UROD(1), UROS(1)	48843888	122	90	120	35	36	15	21	44	6	0	0.130	1.000	1.000
463	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CD28(2), CD3D(1), CSK(2), CTLA4(1), DAG1(3), DTYMK(1), EPHB2(5), FBXW7(6), GRAP2(2), ITK(1), LAT(2), LCK(1), LCP2(1), MAPK1(4), NCK1(2), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PLCG1(12), PTPRC(9), RAF1(2), RASGRP1(2), RASGRP2(3), RASGRP3(2), RASGRP4(3), SOS1(7), SOS2(5), VAV1(9), ZAP70(8)	66328255	130	90	126	30	37	25	15	32	21	0	0.00988	1.000	1.000
464	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(1), APAF1(3), ARHGDIB(1), BAG4(1), BCL2(3), BIRC2(3), BIRC3(1), CASP2(1), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CRADD(2), CYCS(2), DAXX(5), DFFA(2), GSN(2), LMNA(2), LMNB2(3), MAP3K1(9), MAP3K5(4), MAPK8(2), MDM2(5), NFKB1(2), NFKBIA(3), NUMA1(12), PAK2(2), PRKCD(3), PRKDC(14), PSEN1(1), PTK2(2), RASA1(4), RELA(1), RIPK1(4), SPTAN1(8), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF1(1), TRAF2(2)	80259293	122	86	119	37	32	21	19	33	16	1	0.156	1.000	1.000
465	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), AANAT(2), ABP1(4), ACAT2(1), ACMSD(2), AFMID(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AOC2(1), AOX1(9), ASMT(2), CARM1(1), CAT(3), CYP1A2(4), CYP1B1(2), DDC(5), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), HSD17B4(3), KMO(4), KYNU(2), LCMT1(3), LCMT2(2), LNX1(4), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), NFX1(3), OGDH(1), OGDHL(7), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), TDO2(2), TPH1(5), TPH2(2), WARS(1), WARS2(2), WBSCR22(3)	71939912	132	86	129	45	50	17	13	33	19	0	0.244	1.000	1.000
466	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAK1(2), BAX(1), BFAR(1), BTK(3), CAD(8), CASP10(2), CASP8(2), CASP8AP2(1), CD7(3), CSNK1A1(2), DAXX(5), DEDD(1), DEDD2(2), DFFA(2), DIABLO(2), EPHB2(5), FAF1(4), IL1A(1), MAP3K1(9), MAP3K5(4), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2), MET(13), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), NR0B2(1), PTPN13(4), RALBP1(3), RIPK1(4), ROCK1(4), SMPD1(1), TNFRSF6B(1), TPX2(7), TRAF2(2), TUFM(1)	82587963	136	86	134	36	42	26	24	23	21	0	0.0199	1.000	1.000
467	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPS(3), CDS2(2), CHAT(7), CHKB(1), CLC(1), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(2), ETNK1(1), GNPAT(2), GPD2(1), LCAT(1), LYPLA1(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(2), PCYT1B(2), PISD(2), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB2(7), PLCG1(12), PLCG2(12), PPAP2A(2), PPAP2C(1)	59020783	120	85	118	31	40	26	12	28	14	0	0.0131	1.000	1.000
468	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(1), ACSS2(4), ACYP1(1), ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDH7A1(2), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), G6PC2(1), GALM(1), GAPDH(1), GAPDHS(2), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKL(5), PFKP(1), PGAM2(1), PGAM4(2), PGK1(3), PGK2(1), PGM1(1), PGM3(1), PKLR(4), TPI1(1)	68205904	130	85	128	37	49	25	9	33	14	0	0.0163	1.000	1.000
469	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTG2(2), ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), CFL1(1), CFL2(2), FLNA(18), FLNC(15), FSCN1(2), FSCN2(2), FSCN3(3), GDI1(4), GDI2(1), LIMK1(4), MYH2(25), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), ROCK1(4), ROCK2(5), RPS4X(3), VASP(1), WASF1(1), WASL(2)	57053538	131	85	126	42	57	17	15	27	14	1	0.0597	1.000	1.000
470	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(4), ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), AOX1(9), CARM1(1), DBH(4), DCT(1), DDC(5), ECH1(1), ESCO1(2), ESCO2(2), FAH(2), GOT1(2), GOT2(1), GSTZ1(3), HGD(5), HPD(1), LCMT1(3), LCMT2(2), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), PNPLA3(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SH3GLB1(3), TAT(3), TH(3), TPO(10), TYR(5), TYRP1(6), WBSCR22(3)	70627373	137	84	131	38	51	19	14	37	16	0	0.0291	1.000	1.000
471	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPP(7), ALPPL2(6), ASCC3(7), ATP13A2(3), DDX18(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(5), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(4), DHFR(1), DHX58(2), ENTPD7(2), EP400(9), ERCC2(3), ERCC3(2), FPGS(2), GGH(1), IFIH1(3), MOV10L1(7), QDPR(2), RAD54B(5), RAD54L(6), RUVBL2(4), SETX(5), SKIV2L2(3), SMARCA2(5), SMARCA5(3), SPR(1)	74571237	121	84	119	42	40	23	14	27	17	0	0.390	1.000	1.000
472	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(3), BAK1(2), BAX(1), BCL2(3), BCL2L11(1), BIRC2(3), BIRC3(1), CASP1(8), CASP10(2), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CHUK(1), CYCS(2), DFFA(2), FAS(1), FASLG(1), GZMB(3), HELLS(3), IKBKB(2), IRF1(5), IRF2(2), IRF3(3), IRF4(4), IRF5(2), IRF6(4), IRF7(3), MAP3K1(9), MAPK10(1), MDM2(5), NFKB1(2), NFKBIA(3), NFKBIE(3), PLEKHG5(4), PRF1(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF21(2), TNFRSF25(2), TNFSF10(2), TRADD(1), TRAF1(1), TRAF2(2), TRAF3(1)	67092782	118	80	116	37	38	23	9	29	19	0	0.142	1.000	1.000
473	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(1), ALOX12B(2), ALOX15(2), ALOX15B(1), ALOX5(2), CBR1(2), CBR3(1), CYP2B6(6), CYP2C18(3), CYP2C19(6), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP2U1(2), CYP4A11(5), CYP4A22(2), CYP4F2(3), CYP4F3(6), DHRS4(1), EPHX2(2), GGT1(3), GPX1(1), GPX2(2), GPX4(2), GPX5(1), GPX6(1), LTA4H(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PTGES(1), PTGES2(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(2)	46240610	103	80	102	33	37	15	9	25	17	0	0.150	1.000	1.000
474	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPPL1(8), MIOX(1), OCRL(7), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3CB(7), PIK3CG(12), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCG1(12), PLCG2(12)	50675808	108	79	106	42	32	18	12	30	16	0	0.662	1.000	1.000
475	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(3), CHUK(1), DAXX(5), EGF(10), ETS1(5), FOS(2), HOXA7(2), IKBKB(2), MAP2K1(1), MAP2K3(6), MAP3K1(9), MAP3K5(4), MAPK1(4), MAPK13(2), MAPK3(2), MAPK8(2), NFKB1(2), NFKBIA(3), PPP2CA(4), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCQ(4), RAF1(2), RELA(1), RIPK1(4), SP1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRAF2(2)	55196412	106	78	102	33	33	21	14	18	17	3	0.0817	1.000	1.000
476	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), DAG1(3), DGKA(4), GCA(1), ITGA9(2), ITPR1(9), ITPR2(15), ITPR3(18), MAP2K1(1), MAPK1(4), MAPK3(2), NR1I3(1), PAK1(3), PDE3A(5), PDE3B(3), PI3(2), PIK3C2G(10), PIK3CD(3), PSME1(3), RIPK3(1), RPS4X(3), SGCB(1), VASP(1)	53497057	103	77	101	37	28	17	20	19	17	2	0.313	1.000	1.000
477	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	38	AKT1(2), ASAH1(2), ATF1(1), CREB1(2), CREB3(3), CREBBP(13), CRKL(2), DAG1(3), EGR1(5), EGR2(2), EGR3(2), ELK1(5), FRS2(1), MAP1B(10), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2), NTRK1(4), OPN1LW(1), PIK3C2G(10), PIK3CD(3), RPS6KA3(4), SHC1(1), SRC(2), TERF2IP(1), TH(3)	53545487	106	76	105	31	26	16	19	22	22	1	0.0960	1.000	1.000
478	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(1), ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), GAPDH(1), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKP(1), PGK1(3), PGM1(1), PGM3(1), PKLR(4), TPI1(1)	57097894	110	75	108	35	42	25	7	26	10	0	0.0740	1.000	1.000
479	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(1), ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), GAPDH(1), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKP(1), PGK1(3), PGM1(1), PGM3(1), PKLR(4), TPI1(1)	57097894	110	75	108	35	42	25	7	26	10	0	0.0740	1.000	1.000
480	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), CDS2(2), CHAT(7), CHKB(1), CRLS1(1), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(2), ESCO1(2), ESCO2(2), ETNK1(1), ETNK2(2), GNPAT(2), GPAM(1), GPD2(1), LCAT(1), LYPLA1(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PISD(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLD1(8), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(5), SH3GLB1(3)	77903633	112	73	111	26	39	25	10	26	12	0	0.00471	1.000	1.000
481	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	47	ACOX1(2), APOA1(1), CD36(5), CITED2(1), CREBBP(13), DUSP1(1), EHHADH(2), EP300(6), FABP1(1), HSD17B4(3), LPL(2), MAPK1(4), MAPK3(2), ME1(2), NCOA1(3), NCOR1(9), NCOR2(9), NFKBIA(3), NR0B2(1), NR1H3(5), NR2F1(1), NRIP1(4), PDGFA(1), PPARA(4), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PTGS2(3), RELA(1), RXRA(4), SP1(1), STAT5A(1), STAT5B(2), TNF(1)	68617586	109	73	107	40	31	18	11	26	20	3	0.466	1.000	1.000
482	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(3), ASAH1(2), CAV3(1), DAG1(3), DLG4(6), EPHB2(5), GNAI1(4), ITPR1(9), ITPR2(15), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), PITX2(7), PTX3(2), RAC1(1), RYR1(15)	54509157	105	73	105	32	33	19	21	19	12	1	0.0624	1.000	1.000
483	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(3), AXIN1(4), CCND1(4), CCND2(2), CCND3(1), CSNK1E(1), CTNNB1(3), DVL1(1), DVL2(3), DVL3(3), FZD1(3), FZD10(5), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GSK3B(1), LDLR(3), MAPK10(1), MAPK9(2), PAFAH1B1(4), PLAU(1), PPP2R5C(1), PPP2R5E(3), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCI(2), PRKCQ(4), PRKD1(1), RAC1(1), SFRP4(1), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT5B(2), WNT7A(2)	70517248	104	73	103	34	34	11	16	20	21	2	0.209	1.000	1.000
484	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH4A1(2), AMD1(2), AOC2(1), ARG2(2), ASL(2), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), DAO(3), GAMT(1), GATM(2), GLUD1(4), GOT1(2), GOT2(1), MAOA(3), MAOB(2), NOS1(10), NOS3(10), OAT(1), ODC1(3), OTC(2), P4HA1(1), P4HB(1), RARS(3), SMS(2)	52591328	103	70	103	36	41	18	11	23	10	0	0.234	1.000	1.000
485	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(1), CALR(2), CANX(2), CD4(2), CD8A(1), CIITA(4), CREB1(2), CTSB(4), CTSS(1), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(5), HLA-DOA(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(3), HLA-G(2), HSP90AA1(1), HSP90AB1(3), IFI30(1), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), KIR2DL1(6), KIR2DL3(2), KIR2DL4(1), KIR3DL1(1), KIR3DL2(5), KIR3DL3(1), KLRC1(3), KLRC2(5), KLRD1(1), LGMN(1), NFYA(1), NFYB(1), PDIA3(1), PSME1(3), RFX5(2), RFXANK(1), TAP1(2), TAP2(4)	54590904	99	70	98	42	27	17	11	27	17	0	0.725	1.000	1.000
486	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(2), ADCY3(5), ADCY9(11), AK1(1), ARF1(1), ARF6(1), ARL4D(1), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), ERO1L(1), GNAS(4), PDIA4(3), PLCG1(12), PLCG2(12), PRKCA(6), SEC61A1(1), TRIM23(3)	43932351	88	70	86	33	33	18	9	15	12	1	0.415	1.000	1.000
487	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(8), CANT1(4), CDA(3), CTPS2(2), DCK(2), DCTD(1), DHODH(2), DPYD(6), DPYS(5), DTYMK(1), ENTPD1(3), NT5C(3), NT5E(3), NT5M(1), NUDT2(1), POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3), RRM1(3), RRM2(1), TK2(3), TXNRD1(1), UCK1(4), UMPS(1), UPP1(3)	68133374	109	70	108	38	23	20	13	39	14	0	0.566	1.000	1.000
488	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(1), ELK1(5), FOS(2), IKBKB(2), IRAK1(3), LY96(2), MAP2K3(6), MAP3K1(9), MAP3K7(3), MAPK8(2), NFKB1(2), NFKBIA(3), PPARA(4), RELA(1), TLR10(7), TLR2(5), TLR3(6), TLR4(2), TLR6(8), TLR7(10), TLR9(5), TOLLIP(1)	43409096	90	70	85	32	30	18	12	21	9	0	0.312	1.000	1.000
489	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(15), CDR1(1), DGKI(2), FAU(1), IL6ST(3), MRPL19(2), RPL10(6), RPL11(2), RPL13A(2), RPL15(2), RPL18A(1), RPL23(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL36(1), RPL3L(1), RPL6(1), RPL7(3), RPL7A(1), RPLP0(1), RPS11(1), RPS12(2), RPS18(2), RPS19(1), RPS2(1), RPS21(1), RPS24(1), RPS3(3), RPS4X(3), RPS5(1), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(3), RPSA(2), SLC36A2(3), TBC1D10C(3), TSPAN9(1), UBA52(1), UBC(8)	61564681	109	69	108	29	28	16	14	31	20	0	0.223	1.000	1.000
490	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	30	AKT1(2), APC(3), AR(4), ASAH1(2), CCL13(1), CCL15(1), CCL16(1), DAG1(3), GNA11(1), GNA15(1), GNAI1(4), ITPR1(9), ITPR2(15), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), MAPK10(1), PHKA2(5), PIK3CD(3), PITX2(7), PTX3(2), RAF1(2), SRC(2)	54225320	99	69	99	30	25	17	26	19	10	2	0.102	1.000	1.000
491	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(7), ATP4A(6), ATP4B(2), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5I(1), ATP6AP1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), COX10(5), COX15(1), COX17(1), COX6B1(1), COX7A1(1), COX7B(3), COX7B2(1), COX7C(1), LHPP(1), NDUFA10(4), NDUFA12(1), NDUFA3(2), NDUFA4(1), NDUFA7(1), NDUFA9(4), NDUFB1(1), NDUFB11(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), NDUFV3(2), PPA2(1), SDHA(4), SDHC(2), TCIRG1(2), UQCRC1(4), UQCRC2(1), UQCRH(2), UQCRQ(1)	66250051	107	68	105	32	25	17	19	30	15	1	0.163	1.000	1.000
492	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(6), ACTB(2), ACTG1(1), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(3), EZR(4), FYN(2), HCLS1(4), ITGB1(3), KRT18(3), LY96(2), NCK1(2), NCL(3), OCLN(3), PRKCA(6), ROCK1(4), ROCK2(5), TLR4(2), TLR5(4), TUBA1A(3), TUBA1B(1), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3), WAS(3), WASL(2), YWHAQ(1), YWHAZ(1)	61330529	97	66	97	35	34	16	16	18	12	1	0.265	1.000	1.000
493	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(6), ACTB(2), ACTG1(1), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(3), EZR(4), FYN(2), HCLS1(4), ITGB1(3), KRT18(3), LY96(2), NCK1(2), NCL(3), OCLN(3), PRKCA(6), ROCK1(4), ROCK2(5), TLR4(2), TLR5(4), TUBA1A(3), TUBA1B(1), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3), WAS(3), WASL(2), YWHAQ(1), YWHAZ(1)	61330529	97	66	97	35	34	16	16	18	12	1	0.265	1.000	1.000
494	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT(2), AGXT2(2), ALAS1(2), ALAS2(1), AMT(3), AOC2(1), ATP6V0C(1), CBS(5), CHKB(1), CTH(2), DAO(3), DLD(3), DMGDH(4), GAMT(1), GARS(3), GATM(2), GCAT(2), GLDC(3), MAOA(3), MAOB(2), PISD(2), PLCB2(7), PLCG1(12), PLCG2(12), PSPH(2), SARDH(3), SARS(1), SHMT1(2), TARS(1)	49994814	92	64	90	29	31	22	5	24	10	0	0.0917	1.000	1.000
495	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(4), ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), AOX1(9), DBH(4), DCT(1), DDC(5), FAH(2), GOT1(2), GOT2(1), GSTZ1(3), HGD(5), HPD(1), MAOA(3), MAOB(2), TAT(3), TH(3), TPO(10), TYR(5)	37648718	94	64	91	30	43	10	8	27	6	0	0.0949	1.000	1.000
496	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(1), CCND1(4), CREBBP(13), EP300(6), ERCC3(2), ESR1(3), GRIP1(9), GTF2E1(3), GTF2F1(1), HDAC2(7), HDAC3(1), HDAC4(4), HDAC5(1), HDAC6(4), NCOR2(9), NR0B1(1), NRIP1(4), PELP1(2), POLR2A(9), TBP(2)	54982332	92	63	91	31	31	14	7	21	19	0	0.396	1.000	1.000
497	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), ELK1(5), FPR1(1), GNA15(1), GNB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAPK1(4), MAPK3(2), NCF1(3), NCF2(5), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKBIA(3), PAK1(3), PIK3C2G(10), PLCB1(4), PPP3CA(1), PPP3CB(2), PPP3CC(1), RAC1(1), RAF1(2), RELA(1), SYT1(2)	45574438	92	63	89	35	28	13	13	18	19	1	0.394	1.000	1.000
498	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(3), ACADL(1), ACADM(2), ACADS(5), ACADVL(3), ACAT2(1), ACOX1(2), ACOX3(3), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CPT1A(2), CPT1C(2), CPT2(2), CYP4A11(5), CYP4A22(2), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), HSD17B4(3)	58123325	97	62	95	40	28	13	9	27	20	0	0.658	1.000	1.000
499	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GALNT1(2), B3GALT1(2), B3GALT2(1), B3GALT5(2), B3GNT2(1), B3GNT3(4), B3GNT4(2), B3GNT5(4), B4GALNT1(3), B4GALT2(1), B4GALT6(2), FUT2(2), FUT3(2), FUT4(1), FUT5(6), FUT6(3), FUT7(1), GBGT1(2), GCNT2(2), PIGA(3), PIGB(1), PIGC(1), PIGF(1), PIGG(1), PIGN(2), PIGO(5), PIGQ(3), PIGS(2), PIGT(1), PIGU(2), PIGX(1), PIGZ(2), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST3GAL6(5), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3), UGCG(2)	57723749	95	62	95	35	33	11	8	29	14	0	0.595	1.000	1.000
500	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), ATF2(2), DLD(3), DUSP10(2), DUSP4(1), GCK(2), IL1R1(4), MAP2K5(2), MAP3K1(9), MAP3K10(1), MAP3K11(1), MAP3K12(6), MAP3K13(3), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K7(3), MAP3K9(6), MAPK10(1), MAPK7(6), MAPK8(2), MAPK9(2), MYEF2(3), NFATC3(2), NR2C2(3), PAPPA(6), SHC1(1), ZAK(2)	58881298	88	62	86	30	26	17	16	21	8	0	0.386	1.000	1.000
501	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG2(2), ASL(2), ASS1(4), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), DAO(3), EPRS(5), GAMT(1), GATM(2), GLUD1(4), GLUD2(4), GOT1(2), GOT2(1), LAP3(1), NOS1(10), NOS3(10), OAT(1), OTC(2), P4HA1(1), PARS2(2), PRODH(1), RARS(3), RARS2(4)	42713639	86	61	85	32	33	14	11	20	8	0	0.442	1.000	1.000
502	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(2), BCR(3), BLNK(2), BTK(3), CD19(2), CSK(2), DAG1(3), EPHB2(5), LYN(2), MAP2K1(1), MAP2K2(1), MAPK1(4), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PI3(2), PIK3CD(3), PLCG2(12), PPP1R13B(1), RAF1(2), SERPINA4(2), SHC1(1), SOS1(7), SOS2(5), VAV1(9)	58090348	87	61	87	33	28	17	11	21	10	0	0.374	1.000	1.000
503	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), ARHGEF11(4), BCL2(3), DLG4(6), GNA13(1), LPA(11), MAP3K1(9), MAP3K5(4), MAPK8(2), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PDK1(2), PHKA2(5), PI3(2), PIK3CB(7), PLD1(8), PLD3(1), PTK2(2), RDX(5), ROCK1(4), ROCK2(5), SERPINA4(2), SRF(3), TBXA2R(1)	58323241	99	60	97	32	25	22	14	26	11	1	0.285	1.000	1.000
504	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(1), FUCA1(6), FUCA2(4), GBA(1), GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(3), HPSE(5), HPSE2(5), HYAL1(3), HYAL2(1), IDS(2), LCT(13), MAN2B1(7), MAN2B2(7), MAN2C1(2), MANBA(1), NAGLU(3), NEU1(2), NEU3(2), NEU4(2)	38912925	77	58	77	29	27	9	10	22	9	0	0.510	1.000	1.000
505	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(1), ARHGAP1(1), ARHGAP4(4), ARHGAP5(5), ARHGAP6(4), ARHGEF1(1), ARHGEF11(4), ARHGEF5(3), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(1), BAIAP2(3), CFL1(1), DIAPH1(5), GSN(2), LIMK1(4), MYL2(2), MYLK(7), OPHN1(6), PIP5K1B(3), PPP1R12B(1), ROCK1(4), SRC(2), TLN1(5), VCL(1)	54094464	76	57	75	31	18	10	10	27	11	0	0.743	1.000	1.000
506	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(3), AKT1(2), DAG1(3), ITPR1(9), ITPR2(15), ITPR3(18), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PDK1(2), PHKA2(5), PIK3CB(7), PITX2(7), PLD1(8), PLD3(1)	53359498	90	57	90	33	28	18	14	22	6	2	0.297	1.000	1.000
507	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), AASS(1), ACAT2(1), AKR1B10(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), DOT1L(4), ECHS1(3), EHHADH(2), EHMT1(5), EHMT2(5), GCDH(1), HADHA(3), HSD17B4(3), HSD3B7(1), NSD1(5), OGDH(1), OGDHL(7), PIPOX(2), PLOD1(3), PLOD2(2), PLOD3(1), SETD1A(4), SETD7(2), SETDB1(8), SHMT1(2), SUV39H1(2), SUV39H2(1), TMLHE(2)	69034345	94	56	94	43	35	12	9	24	14	0	0.812	1.000	1.000
508	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(1), EIF2B1(1), EIF2B4(1), EIF2S2(2), EIF2S3(2), ELAVL1(1), FLT1(10), FLT4(8), KDR(14), NOS3(10), PLCG1(12), PRKCA(6), PTK2(2), PXN(1), SHC1(1)	35968174	72	56	70	32	20	12	11	19	9	1	0.760	1.000	1.000
509	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(2), AKR1D1(1), ARSD(3), ARSE(6), CYP11B1(3), CYP11B2(3), HSD11B1(2), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), SRD5A1(2), SRD5A2(1), STS(2), SULT2A1(2), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(3), UGT2B4(9)	32485666	67	54	66	27	23	12	10	17	5	0	0.412	1.000	1.000
510	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAX(1), BCL2(3), BCL2A1(1), BOK(1), CASP1(8), CASP10(2), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CD40(1), CD40LG(2), CRADD(2), CYCS(2), DAXX(5), DFFA(2), FAS(1), FASLG(1), IKBKE(5), MCL1(1), NFKB1(2), NFKBIA(3), NGFR(1), NR3C1(3), NTRK1(4), PTPN13(4), RIPK1(4), TFG(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF1(1), TRAF2(2), TRAF3(1)	51772317	78	54	78	29	21	13	5	21	18	0	0.575	1.000	1.000
511	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDK2(1), CDT1(1), DIAPH2(5), GMNN(1), MCM10(4), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), NACA(6), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), PRIM1(2), RFC1(2), RFC4(4), RPA1(3), RPA2(1), RPA4(2), UBA52(1), UBC(8)	60300898	87	52	87	36	15	12	11	30	19	0	0.833	1.000	1.000
512	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(19), C5(7), C6(4), C7(5), ICAM1(3), IL1A(1), IL6(2), ITGA4(8), ITGAL(2), ITGB1(3), ITGB2(5), SELP(4), SELPLG(3), TNF(1), VCAM1(2)	29462150	69	52	69	32	20	9	10	18	12	0	0.733	1.000	1.000
513	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(3), CXCR4(2), GNAI1(4), GNB1(1), MAP2K1(1), MAPK1(4), MAPK3(2), NFKB1(2), PIK3C2G(10), PLCG1(12), PRKCA(6), PTK2(2), PTK2B(5), PXN(1), RAF1(2), RELA(1)	28414196	58	50	56	22	17	5	13	12	9	2	0.523	1.000	1.000
514	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(3), EEF1A2(1), EEF1B2(1), EEF1D(3), EEF2(2), EEF2K(2), EIF1AX(4), EIF2AK1(1), EIF2AK2(1), EIF2AK3(3), EIF2B1(1), EIF2B4(1), EIF2S2(2), EIF2S3(2), EIF4A1(7), EIF4A2(2), EIF4E(2), EIF4G1(5), EIF4G3(7), EIF5A(1), EIF5B(1), GSPT2(6), PABPC1(4), PABPC3(5), PAIP1(1), SLC35A4(1)	52195259	69	50	68	26	17	10	6	23	13	0	0.735	1.000	1.000
515	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	19	ADCYAP1R1(5), CALCRL(1), CD97(3), CRHR2(5), ELTD1(6), EMR1(5), EMR2(6), GHRHR(3), GIPR(2), GLP1R(2), GLP2R(3), GPR64(4), LPHN1(2), LPHN2(8), LPHN3(7), SCTR(1), VIPR1(1), VIPR2(2)	30616739	66	49	65	30	19	7	13	23	4	0	0.809	1.000	1.000
516	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(1), DARS(1), DARS2(2), EARS2(1), EPRS(5), FARS2(3), FARSA(1), GARS(3), HARS(4), HARS2(1), IARS(4), IARS2(3), KARS(2), LARS(4), MARS(7), MARS2(2), MTFMT(1), NARS(1), NARS2(1), PARS2(2), QARS(5), RARS(3), RARS2(4), SARS(1), SARS2(2), TARS(1), TARS2(2), VARS(4), VARS2(3), WARS(1), WARS2(2), YARS(1), YARS2(1)	64422010	83	49	83	23	11	19	11	29	13	0	0.309	1.000	1.000
517	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A2(1), GTF2E1(3), GTF2F1(1), GTF2H1(3), GTF2H4(2), GTF2IRD1(4), STON1(2), TAF1(12), TAF10(1), TAF1L(13), TAF2(6), TAF4(5), TAF4B(3), TAF5L(2), TAF6(2), TAF6L(1), TAF7(1), TAF7L(6), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(2)	42817761	74	49	74	23	17	11	8	25	12	1	0.453	1.000	1.000
518	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(3), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC4(2), ANAPC5(5), ANAPC7(2), BTRC(2), CDC16(2), CDC20(1), CDC23(4), CDC27(5), CUL1(4), CUL2(7), CUL3(1), FBXW11(1), FBXW7(6), FZR1(4), ITCH(1), RBX1(1), SKP2(4), SMURF1(4), SMURF2(2), UBE2D4(2), UBE2E3(1), WWP1(3), WWP2(2)	47872334	73	49	73	27	18	11	13	22	9	0	0.696	1.000	1.000
519	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(1), CREB1(2), CREB3(3), DUSP1(1), DUSP10(2), EEF2K(2), EIF4E(2), ELK1(5), IL1R1(4), MAP2K3(6), MAP3K10(1), MAP3K4(7), MAP3K5(4), MAP3K7(3), MAPK1(4), MAPK12(2), MAPK13(2), MAPKAPK2(2), MAPKAPK5(2), MKNK1(2), MYEF2(3), NFKB1(2), NR2C2(3), SRF(3)	39621956	70	49	70	25	19	11	15	15	10	0	0.465	1.000	1.000
520	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(7), APOA1(1), APOA4(3), APOE(2), CETP(3), CYP7A1(3), DGAT1(2), LCAT(1), LDLR(3), LIPC(1), LPL(2), LRP1(29), SCARB1(2), SOAT1(5)	32505871	64	48	64	25	15	11	6	20	12	0	0.694	1.000	1.000
521	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(6), GABBR1(2), GPRC5C(1), GPRC5D(2), GRM1(7), GRM2(4), GRM3(16), GRM4(6), GRM5(6), GRM7(5), GRM8(7)	24925941	62	47	60	40	34	5	3	15	5	0	0.973	1.000	1.000
522	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(3), ALG12(2), ALG13(4), ALG14(1), ALG3(4), ALG5(3), ALG6(3), B4GALT2(1), DAD1(1), DHDDS(1), DPAGT1(2), DPM1(3), FUT8(7), GANAB(5), MAN1A1(3), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), MGAT5B(3), RPN1(1), RPN2(1), ST6GAL1(2), STT3B(2)	50341004	73	45	73	26	18	19	10	10	16	0	0.396	1.000	1.000
523	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(3), ACAD8(4), ACAD9(1), ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1B10(3), AKR1C4(2), AKR1D1(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), BAAT(1), CEL(4), CYP27A1(2), CYP7A1(3), HSD3B7(1), LIPA(2), SLC27A5(4), SOAT1(5), SOAT2(1), SRD5A1(2), SRD5A2(1)	37576345	76	44	76	32	20	11	9	30	6	0	0.772	1.000	1.000
524	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR7(1), CD28(2), CD4(2), CSF2(2), CXCR4(2), IFNG(2), IFNGR1(1), IFNGR2(4), IL12B(4), IL12RB1(4), IL12RB2(4), IL18R1(4), IL4R(9), IL5(1), TGFB2(2), TGFB3(1)	23771415	54	43	53	24	20	3	8	16	7	0	0.695	1.000	1.000
525	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(3), AXIN1(4), CREBBP(13), CTNNB1(3), DVL1(1), EP300(6), FZD1(3), GSK3B(1), LDB1(2), LEF1(1), PITX2(7), TRRAP(18), WNT1(1)	39411320	63	43	63	25	16	9	9	17	12	0	0.680	1.000	1.000
526	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(2), BCL2(3), CBL(2), CFLAR(1), CRKL(2), E2F1(1), FOS(2), IL2RB(2), IRS1(8), JAK1(3), JAK3(5), MAPK1(4), MAPK3(2), PTPN6(1), RAF1(2), RPS6KB1(2), SHC1(1), SOCS1(1), SOS1(7), STAT5A(1), STAT5B(2)	38525376	54	42	54	22	11	9	7	14	12	1	0.742	1.000	1.000
527	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(3), ACTN2(6), ACTN3(1), BCAR1(3), BCR(3), CAPN1(2), CAPNS1(2), CAPNS2(1), CRKL(2), CSK(2), FYN(2), ITGA1(4), ITGB1(3), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MAPK8(2), PPP1R12B(1), PTK2(2), PXN(1), RAF1(2), ROCK1(4), SHC1(1), SOS1(7), SRC(2), TLN1(5), VCL(1), ZYX(2)	56050622	72	42	72	19	22	11	14	17	7	1	0.0867	1.000	1.000
528	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(2), EGF(10), MAP2K1(1), MAPK1(4), MAPK3(2), PTPRB(9), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SPRY1(1), SPRY2(3), SPRY3(3), SPRY4(3), SRC(2)	26493380	54	42	54	19	14	4	7	15	13	1	0.615	1.000	1.000
529	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(2), C1QB(1), C1R(2), C1S(5), C2(2), C3(19), C5(7), C6(4), C7(5), C8A(4), C8B(7), C9(2), MASP1(2)	24743881	62	40	62	28	21	10	4	19	8	0	0.778	1.000	1.000
530	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(3), ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), FPGT(1), GMDS(1), GMPPA(2), HK1(4), HK2(5), HK3(5), HSD3B7(1), LHPP(1), MPI(1), MTMR1(6), MTMR2(3), MTMR6(1), PFKFB1(6), PFKFB2(2), PFKFB3(2), PFKFB4(1), PFKL(5), PFKP(1), PGM2(4), PMM1(1), SORD(1), TPI1(1), TSTA3(1)	44206222	67	40	67	26	29	11	6	12	9	0	0.404	1.000	1.000
531	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(1), FUCA1(6), FUCA2(4), GLB1(2), HEXA(1), HEXB(1), LCT(13), MAN2B1(7), MAN2B2(7), MAN2C1(2), MANBA(1), NEU1(2), NEU3(2), NEU4(2)	23341016	51	40	51	20	16	6	7	16	6	0	0.594	1.000	1.000
532	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(3), ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1C4(2), AKR1D1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), BAAT(1), CEL(4), CYP27A1(2), CYP7A1(3), SOAT2(1), SRD5A1(2), SRD5A2(1)	27602759	57	39	57	25	18	9	6	20	4	0	0.705	1.000	1.000
533	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(2), C1QB(1), C1R(2), C1S(5), C2(2), C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2), MASP1(2), MASP2(1), MBL2(4)	25330880	60	39	60	25	20	7	5	19	9	0	0.708	1.000	1.000
534	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(6), ICAM1(3), ITGA4(8), ITGAL(2), ITGAM(7), ITGB1(3), ITGB2(5), SELE(8), SELP(4)	18965826	46	39	45	25	18	5	10	8	5	0	0.809	1.000	1.000
535	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA2(2), ANXA3(3), ANXA5(1), ANXA6(3), CYP11A1(7), EDNRA(1), EDNRB(1), HPGD(1), HSD11B1(2), PLA2G4A(7), PRL(1), PTGER4(2), PTGFR(7), PTGIS(2), PTGS1(3), PTGS2(3), SCGB1A1(1), TBXAS1(2)	24524396	51	38	51	22	16	5	4	16	10	0	0.734	1.000	1.000
536	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(2), CLOCK(3), CRY1(3), DNAJA1(3), EIF4G2(1), ETV6(4), GFRA1(1), HERPUD1(2), HSPA8(3), IDI1(2), KLF9(3), MYF6(2), NCKAP1(5), NCOA4(3), NR1D2(1), PER1(6), PER2(6), PIGF(1), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(2), TOB1(1), UGP2(1), ZFR(3)	43503986	62	37	61	21	14	11	9	21	7	0	0.542	1.000	1.000
537	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLA2(2), POLB(3), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLG(1), POLH(1), POLI(5), POLK(2), POLL(2), POLM(3), POLQ(7), PRIM1(2), PRIM2(2), REV1(5), REV3L(8)	48288701	63	37	63	22	16	8	7	22	10	0	0.734	1.000	1.000
538	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	CAPN1(2), CAPNS1(2), CAPNS2(1), EGF(10), ITGA1(4), ITGB1(3), MAPK1(4), MAPK3(2), MYL2(2), MYLK(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTK2(2), PXN(1), TLN1(5)	35740505	50	37	50	21	18	2	10	15	4	1	0.724	1.000	1.000
539	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(2), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(9), MAP3K7(3), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TLR4(2), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(3), TRADD(1)	28972291	43	37	41	21	15	12	4	6	6	0	0.754	1.000	1.000
540	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(5), ARHGEF1(1), F2(4), F2R(2), F2RL3(3), GNA13(1), GNAI1(4), GNB1(1), MAP3K7(3), PLCB1(4), PPP1R12B(1), PRKCA(6), PTK2B(5), ROCK1(4)	26265063	44	37	44	19	14	6	6	10	7	1	0.657	1.000	1.000
541	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(1), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2), MAPKAPK5(2), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PIK3CD(3), SYT1(2), TRAF2(2), TRAF3(1), TRAF5(3)	35471100	52	37	52	18	18	8	9	9	7	1	0.284	1.000	1.000
542	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	ACO2(4), DLD(3), FH(1), IDH3A(1), IDH3B(1), OGDH(1), PC(4), PDHA1(6), PDHA2(7), PDHB(1), PDK1(2), PDK3(3), PDK4(2), PDP2(3), SDHA(4), SDHC(2), SUCLA2(1), SUCLG1(2), SUCLG2(1)	32786073	49	36	46	19	10	12	7	13	7	0	0.500	1.000	1.000
543	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(3), AASDHPPT(1), AASS(1), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ATP6V0C(1), DOT1L(4), ECHS1(3), EHHADH(2), EHMT1(5), EHMT2(5), GCDH(1), HADHA(3), PLOD1(3), PLOD2(2), PLOD3(1), SDS(1), SHMT1(2), TMLHE(2)	44051689	62	36	62	32	26	10	7	10	9	0	0.794	1.000	1.000
544	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(1), CHUK(1), CRADD(2), IKBKB(2), MAP2K3(6), MAP3K1(9), MAP4K2(1), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TANK(3), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2)	28720723	43	36	41	20	14	11	3	7	8	0	0.748	1.000	1.000
545	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(2), C1QB(1), C1R(2), C1S(5), C2(2), C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2)	20838544	53	35	53	22	18	5	4	18	8	0	0.739	1.000	1.000
546	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(10), MAP2K1(1), MAP3K1(9), NCOR2(9), RXRA(4), THRA(5), THRB(2)	17395120	40	35	36	15	13	9	3	7	8	0	0.609	1.000	1.000
547	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(2), DERA(1), FBP1(3), FBP2(2), G6PD(3), GPI(2), H6PD(3), PFKL(5), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(3), PRPS2(5), RBKS(1), RPE(1), RPIA(1), TALDO1(2), TKT(2), TKTL1(1), TKTL2(3)	28876038	47	35	47	21	21	9	2	7	8	0	0.540	1.000	1.000
548	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(1), IFNG(2), IKBKB(2), MAP3K1(9), MAP3K5(4), MAP4K5(1), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), TNFRSF9(4), TNFSF9(5), TRAF2(2)	23034618	40	34	35	16	11	8	6	4	11	0	0.604	1.000	1.000
549	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(3), ASNS(4), CA1(1), CA12(3), CA13(1), CA14(1), CA2(1), CA5A(1), CA6(1), CA9(1), CPS1(8), CTH(2), GLS(3), GLS2(1), GLUD1(4), GLUD2(4), GLUL(2), HAL(3)	25221894	44	34	44	16	15	8	3	12	6	0	0.516	1.000	1.000
550	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(3), CREBBP(13), EP300(6), FYN(2), IL7(1), IL7R(3), JAK1(3), JAK3(5), LCK(1), PTK2B(5), STAT5A(1), STAT5B(2)	28818193	45	34	45	18	10	7	5	13	10	0	0.732	1.000	1.000
551	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(1), AGT(3), AGTR2(4), EDNRA(1), EDNRB(1), EGF(10), FOS(2), NFKB1(2), PLCG1(12), PRKCA(6), RELA(1)	21212030	43	33	41	19	12	6	5	16	3	1	0.789	1.000	1.000
552	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), CDK7(1), ERCC3(2), GTF2A2(1), GTF2E1(3), GTF2H1(3), GTF2H4(2), ILK(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3B(3), POLR3D(1), POLR3E(1), POLR3K(1), TAF6(2), TAF7(1), TAF9(2), TBP(2)	41585824	54	33	54	31	12	10	6	18	8	0	0.982	1.000	1.000
553	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM3(1), CCL2(1), CCR5(1), CXCR4(2), FOS(2), MAPK8(2), PLCG1(12), PRKCA(6), PTK2B(5), SYT1(2)	16358037	35	32	33	14	8	7	7	8	4	1	0.452	1.000	1.000
554	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	22	ARSA(1), ARSD(3), ARSE(6), ASAH1(2), GAL3ST1(2), GALC(1), GBA(1), GLA(2), GLB1(2), LCT(13), NEU1(2), NEU3(2), NEU4(2), PPAP2A(2), PPAP2C(1), SMPD1(1), SMPD2(1), SPTLC1(2), SPTLC2(2), UGCG(2)	27920734	50	32	50	21	19	6	8	14	2	1	0.635	1.000	1.000
555	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(3), ELK1(5), FOS(2), IL2RB(2), JAK1(3), JAK3(5), LCK(1), MAP2K1(1), MAPK3(2), MAPK8(2), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2)	27812961	39	32	39	17	8	7	4	11	8	1	0.734	1.000	1.000
556	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), GTF2E1(3), GTF2F1(1), HDAC3(1), NCOA1(3), NCOA2(5), NCOA3(4), NCOR2(9), POLR2A(9), RXRA(4), TBP(2)	29674222	43	32	42	24	8	8	1	14	12	0	0.974	1.000	1.000
557	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(3), EXTL1(4), EXTL2(2), EXTL3(1), HS3ST1(3), HS3ST3A1(3), HS6ST2(4), HS6ST3(1), NDST1(2), NDST2(2), NDST3(4), NDST4(8)	24655154	40	31	39	16	18	2	10	9	1	0	0.589	1.000	1.000
558	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(6), ICAM1(3), ITGA4(8), ITGAL(2), ITGB1(3), ITGB2(5), SELE(8)	14402972	35	31	34	19	13	5	8	4	5	0	0.755	1.000	1.000
559	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(3), BIRC3(1), CASP8(2), CFLAR(1), MAP3K3(2), MAP3K7(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), NR2C2(3), RALBP1(3), RIPK1(4), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2)	32344243	43	31	43	16	14	8	6	9	6	0	0.541	1.000	1.000
560	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(9), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TANK(3), TNFAIP3(2), TNFRSF1B(3), TRAF1(1), TRAF2(2), TRAF3(1)	26666594	38	31	36	16	15	8	2	7	6	0	0.559	1.000	1.000
561	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2)	14944859	41	30	41	19	14	3	4	12	8	0	0.812	1.000	1.000
562	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(5), CR2(8), HLA-DRA(4), HLA-DRB1(1), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9)	18066385	37	30	37	19	14	7	1	9	6	0	0.816	1.000	1.000
563	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(1), AP2M1(1), ARF1(1), BTK(3), EEA1(3), GRASP(1), GSK3B(1), LYN(2), PFKL(5), PFKP(1), PLCG1(12), PRKCE(1), RAC1(1), RPS6KB1(2), VAV2(4)	29672394	41	30	39	20	10	11	6	8	6	0	0.729	1.000	1.000
564	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(2), CBS(5), CTH(2), DNMT1(3), DNMT3A(11), DNMT3B(4), MARS(7), MARS2(2), MAT1A(2), MTFMT(1), MTR(2), SRM(2), TAT(3)	24608089	46	29	45	18	13	9	3	13	6	2	0.494	1.000	1.000
565	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT2(1), B3GNT3(4), B3GNT4(2), B3GNT5(4), B4GALT2(1), FUT2(2), FUT3(2), FUT4(1), FUT5(6), FUT6(3), FUT7(1), GCNT2(2), ST3GAL6(5), ST8SIA1(2)	19221009	37	29	37	15	13	5	3	10	6	0	0.694	1.000	1.000
566	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(5), G6PD(3), GCLC(1), GGT1(3), GPX1(1), GPX2(2), GPX4(2), GPX5(1), GSS(2), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(3), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), PGD(1)	19526385	35	27	35	13	11	7	6	6	5	0	0.468	1.000	1.000
567	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(3), GLB1(2), HEXA(1), HEXB(1), LCT(13), SLC33A1(4), ST3GAL1(3), ST3GAL2(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3)	19559789	38	27	38	17	14	3	4	8	9	0	0.857	1.000	1.000
568	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(6), ICAM1(3), ITGAL(2), ITGAM(7), ITGB2(5), SELE(8)	12373445	31	27	30	19	15	4	5	3	4	0	0.820	1.000	1.000
569	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), G6PD(3), GPI(2), H6PD(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(3), PRPS2(5), RBKS(1), RPE(1), RPIA(1), TAL1(1), TALDO1(2), TKT(2)	24255598	38	26	38	19	15	9	2	6	6	0	0.650	1.000	1.000
570	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(3), FYN(2), LRP8(1), RELN(25), VLDLR(2)	16639277	33	26	33	20	12	7	5	4	5	0	0.853	1.000	1.000
571	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(3), ESR2(6), PDE1A(3), PDE1B(2), PLCB1(4), PLCB2(7), PRL(1), TRH(1), VIP(2)	13203068	29	26	29	12	9	7	0	8	5	0	0.671	1.000	1.000
572	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), FPGT(1), GCK(2), GMDS(1), GMPPA(2), HK1(4), HK2(5), HK3(5), MPI(1), PFKFB1(6), PFKFB3(2), PFKFB4(1), PFKP(1), PMM1(1), SORD(1), TPI1(1)	28424515	42	25	42	17	18	10	2	7	5	0	0.352	1.000	1.000
573	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(2), B4GALT2(1), CHST1(2), CHST2(2), CHST4(2), CHST6(2), FUT8(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3)	14826172	28	25	28	12	12	4	5	4	3	0	0.610	1.000	1.000
574	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1)	27852536	39	25	39	14	10	6	7	11	5	0	0.505	1.000	1.000
575	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(2), IL22RA1(1), JAK1(3), JAK2(5), JAK3(5), STAT1(4), STAT3(3), STAT5A(1), STAT5B(2), TYK2(10)	21916241	36	25	36	15	12	1	2	14	6	1	0.750	1.000	1.000
576	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	10	DNM1(1), GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), GPHN(1), NSF(2), SRC(2), UBQLN1(2)	11981990	29	24	29	14	4	9	5	7	4	0	0.825	1.000	1.000
577	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), GOT1(2), GOT2(1), ME1(2), ME3(1), PGK1(3), PGK2(1), PKLR(4), RPE(1), RPIA(1), TKT(2), TKTL1(1), TKTL2(3), TPI1(1)	23926747	31	24	31	18	10	6	1	10	4	0	0.939	1.000	1.000
578	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(3), GOSR2(1), SNAP29(1), STX11(2), STX16(1), STX5(1), STX6(1), STX7(1), TSNARE1(4), USE1(3), VAMP4(1), VAMP5(3), VAMP7(3), VAMP8(1), VTI1A(2)	19867381	28	24	27	13	10	3	6	5	4	0	0.741	1.000	1.000
579	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(5), ARHGEF1(1), GNA13(1), GNB1(1), MYL2(2), MYLK(7), PLCB1(4), PPP1R12B(1), PRKCA(6), ROCK1(4)	24524358	32	24	31	18	10	3	4	10	4	1	0.930	1.000	1.000
580	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD8A(1), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9)	12760398	27	24	26	19	12	4	1	6	4	0	0.951	1.000	1.000
581	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9)	13391547	28	24	27	19	12	4	1	7	4	0	0.948	1.000	1.000
582	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(12), PRKCA(6), PTK2B(5)	7994338	26	23	24	13	9	4	3	6	3	1	0.735	1.000	1.000
583	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(5), CTH(2), DNMT1(3), DNMT3A(11), DNMT3B(4), MARS(7), MARS2(2), MAT1A(2), MTR(2)	20673971	38	23	38	16	9	8	2	11	6	2	0.601	1.000	1.000
584	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(2), BPNT1(1), ILK(1), MAPK1(4), MAPK3(2), PDK1(2), PIK3CD(3), PTK2B(5), RBL2(3), SHC1(1), SOS1(7)	20654038	31	23	31	12	7	6	3	11	3	1	0.579	1.000	1.000
585	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(3), JAK2(5), JAK3(5), PIAS1(2), PIAS3(3), PTPRU(3), REG1A(2), SOAT1(5)	16359794	29	23	29	11	5	3	3	10	8	0	0.709	1.000	1.000
586	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(2), ALOX15B(1), ALOX5(2), ALOX5AP(1), DPEP1(2), GGT1(3), LTA4H(4), PLA2G6(3), PTGES(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(2)	17885423	30	22	30	13	10	8	2	4	6	0	0.577	1.000	1.000
587	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(2), CYP51A1(2), DHCR24(2), DHCR7(4), FDFT1(1), FDPS(3), GGCX(1), GGPS1(1), HSD17B7(2), IDI1(2), IDI2(1), LSS(1), MVD(4), MVK(1), NQO1(2), NSDHL(2), SQLE(1)	22923525	32	22	31	12	9	4	7	8	4	0	0.638	1.000	1.000
588	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), GOT1(2), GOT2(1), ME1(2), ME2(2), ME3(1), PGK1(3), PKLR(4), RPE(1), RPIA(1), TKT(2), TPI1(1)	21403975	28	21	28	14	8	6	1	10	3	0	0.846	1.000	1.000
589	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	13	AKT1(2), CREB1(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAPK1(4), MAPK3(2), NFKB1(2), RELA(1), SP1(1)	16521618	31	21	29	11	11	8	4	2	5	1	0.397	1.000	1.000
590	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ECHS1(3), EHHADH(2), HADHA(3), SDS(1)	14437041	29	21	29	14	12	5	3	4	5	0	0.612	1.000	1.000
591	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(9), NFKB1(2), NFKBIA(3), RELA(1), TNFAIP3(2), TRAF3(1)	21553197	25	20	23	12	9	6	2	5	3	0	0.704	1.000	1.000
592	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(2), DRD1(1), DRD2(1), GRM1(7), PLCB1(4), PPP1CA(1), PPP1R1B(1), PPP2CA(4), PPP3CA(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1)	19058977	27	20	27	11	10	3	1	11	2	0	0.756	1.000	1.000
593	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3D(1), CD3E(2), CD3G(1), GZMB(3), HLA-A(1), ICAM1(3), ITGAL(2), ITGB2(5), PRF1(3)	10373523	22	19	22	13	11	2	2	2	5	0	0.783	1.000	1.000
594	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(4), ACAD9(1), ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(3)	29663005	35	19	34	13	8	7	2	17	1	0	0.663	1.000	1.000
595	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(2), GPR161(3), GPR171(1), GPR18(2), GPR34(4), GPR45(4), GPR65(2), GPR68(1), GPR75(2)	11685644	23	18	23	11	7	3	4	4	5	0	0.639	1.000	1.000
596	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(3), CREB1(2), EP300(6), EPO(2), LDHA(1), NOS3(10), P4HB(1)	20239599	26	18	26	13	12	2	2	8	2	0	0.836	1.000	1.000
597	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(3), ACYP1(1), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(3), EHHADH(2), ESCO1(2), ESCO2(2), GCDH(1), HADHA(3), ITGB1BP3(1), PNPLA3(1), SH3GLB1(3), YOD1(1)	30823071	29	18	28	11	10	8	3	4	4	0	0.479	1.000	1.000
598	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(3), ATIC(1), DHFR(1), FTCD(4), GART(4), MTFMT(1), MTHFD1(3), MTHFD1L(1), MTHFR(7), MTHFS(2), MTR(2), SHMT1(2)	22492513	34	17	34	13	9	7	7	4	6	1	0.443	1.000	1.000
599	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), DHFR(1), HPRT1(1), IMPDH1(5), OAZ1(1), POLB(3), POLD1(3), POLG(1), PRPS2(5), RRM1(3), SRM(2)	14853006	29	17	29	12	12	5	5	5	2	0	0.537	1.000	1.000
600	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GLB1(2), GUSB(3), HEXA(1), HEXB(1), IDS(2), LCT(13), NAGLU(3)	17105985	25	16	25	11	10	3	4	4	4	0	0.674	1.000	1.000
601	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL2(2), IFNAR1(2), IFNAR2(3), IFNB1(2), MAPK8(2), NFKB1(2), RELA(1), TNFRSF11A(4), TNFSF11(1)	13172312	21	16	21	12	4	7	2	7	1	0	0.870	1.000	1.000
602	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(3), CRY1(3), CSNK1D(2), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(6), PER2(6), PER3(2)	20310019	25	15	24	13	6	7	1	9	2	0	0.898	1.000	1.000
603	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), HMOX1(1), IL10(1), IL10RB(1), IL1A(1), IL6(2), JAK1(3), STAT1(4), STAT3(3), STAT5A(1), TNF(1)	14452722	20	15	20	10	4	3	2	8	2	1	0.788	1.000	1.000
604	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(7)	19793532	26	14	26	15	9	3	2	11	1	0	0.953	1.000	1.000
605	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(2), ACOX3(3), ELOVL2(2), ELOVL6(1), FADS2(2), FASN(3), HADHA(3), PECR(2), SCD(1)	17075150	20	14	20	17	4	5	2	7	2	0	0.984	1.000	1.000
606	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(6), CLTA(1), COPA(2), GBF1(4), GPLD1(1), KDELR1(2), KDELR2(1), KDELR3(1)	19247103	19	13	19	10	4	6	3	3	3	0	0.799	1.000	1.000
607	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(3), ACAT2(1), ECHS1(3), EHHADH(2), HADHA(3), SDS(1)	9915205	14	12	14	10	2	4	2	2	4	0	0.921	1.000	1.000
608	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT2(2), GBGT1(2), GLA(2), HEXA(1), HEXB(1), ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), ST8SIA1(2)	12005633	17	12	17	11	6	2	1	5	3	0	0.977	1.000	1.000
609	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(2), B3GALT5(2), FUT2(2), GBGT1(2), GLA(2), HEXA(1), HEXB(1), ST3GAL1(3), ST3GAL2(1), ST8SIA1(2)	12742387	18	12	18	13	5	2	1	7	3	0	0.991	1.000	1.000
610	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(1), CNR2(3), DNMT1(3), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGER4(2), PTGFR(7), TBXA2R(1)	13305806	24	12	24	19	9	3	0	10	2	0	0.982	1.000	1.000
611	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(2), TAX1BP3(1), UBE2E3(1), UBE2G2(1), UBE2J2(1), UBE2L6(1), UBE2M(2), UBE3A(1)	12501412	12	12	12	12	6	1	2	1	2	0	0.987	1.000	1.000
612	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(2), HSD3B7(1)	5693548	6	6	6	5	3	0	0	3	0	0	0.958	1.000	1.000
613	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA3(2), LTB4R(1), P2RY1(1), P2RY2(3), P2RY6(2)	7080381	9	4	9	8	5	2	0	2	0	0	0.944	1.000	1.000
614	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		603256	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		1815426	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		2029362	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000