rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(6), AKT1(2), APAF1(3), ATM(12), BAX(1), BCL2(3), BIRC2(3), BIRC3(1), CAPN1(2), CASP10(2), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CSF2RB(6), CYCS(2), DFFA(2), FAS(1), FASLG(1), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1RAP(2), IL3(2), IL3RA(4), IRAK1(3), IRAK2(3), IRAK3(9), IRAK4(2), NFKB1(2), NFKB2(2), NFKBIA(3), NTRK1(4), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RELA(1), RIPK1(4), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(2), TP53(408), TRADD(1), TRAF2(2) 99368867 701 467 403 59 182 97 106 153 155 8 <1.00e-15 <1.00e-15 <2.37e-14 2 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(5), G6PD(3), GCLC(1), GGT1(3), GPX1(1), GPX2(2), GPX4(2), GPX5(1), GSS(2), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(3), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), IDH1(412), IDH2(20), PGD(1) 21465415 467 448 40 13 402 19 8 33 5 0 <1.00e-15 <1.00e-15 <2.37e-14 3 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), BCL2(3), EGFR(138), IGF1R(10), POLR2A(9), PPP2CA(4), PRKCA(6), RB1(30), TEP1(12), TERF1(1), TERT(5), TNKS(2), TP53(408), XRCC5(4) 33523326 634 447 310 25 173 110 72 153 117 9 <1.00e-15 <1.00e-15 <2.37e-14 4 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(6), ACO2(4), DLD(3), FH(1), IDH1(412), IDH2(20), IDH3A(1), IDH3B(1), PC(4), PCK1(6), SDHA(4), SUCLA2(1), SUCLG1(2), SUCLG2(1) 24437050 466 444 38 5 399 21 7 36 3 0 <1.00e-15 <1.00e-15 <2.37e-14 5 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(6), CDKN2A(6), E2F1(1), MDM2(5), PIK3CA(83), PIK3R1(56), POLR1A(7), POLR1B(3), RAC1(1), RB1(30), TBX2(1), TP53(408) 24072269 607 438 306 14 150 74 94 116 164 9 <1.00e-15 <1.00e-15 <2.37e-14 6 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(6), ACO2(4), ACSS1(1), ACSS2(4), FH(1), IDH1(412), IDH2(20), SUCLA2(1) 15772905 453 438 26 1 397 17 4 31 4 0 <1.00e-15 <1.00e-15 <2.37e-14 7 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(6), ACO2(4), FH(1), IDH1(412), IDH2(20), SUCLA2(1) 10558174 444 435 17 0 394 15 4 30 1 0 <1.00e-15 <1.00e-15 <2.37e-14 8 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(6), ATM(12), BUB1(5), BUB1B(2), BUB3(3), CCNA1(3), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNH(2), CDAN1(5), CDC14A(2), CDC14B(5), CDC20(1), CDC25A(1), CDC25B(1), CDC6(1), CDC7(2), CDH1(4), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(6), CHEK1(6), CHEK2(3), DTX4(4), E2F1(1), E2F2(1), E2F3(1), E2F4(1), E2F5(1), E2F6(1), EP300(6), ESPL1(8), GSK3B(1), HDAC2(7), HDAC3(1), HDAC4(4), HDAC5(1), HDAC6(4), MAD1L1(1), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), MPEG1(3), MPL(5), PLK1(2), PRKDC(14), PTPRA(7), RB1(30), RBL1(6), SKP2(4), SMAD4(1), TBC1D8(4), TFDP1(1), TP53(408), WEE1(2) 130682876 650 408 400 72 180 87 83 149 140 11 <1.00e-15 <1.00e-15 <2.37e-14 9 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(3), BAK1(2), BAX(1), BCL2(3), BCL2L11(1), BIRC2(3), BIRC3(1), CASP1(8), CASP10(2), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CHUK(1), CYCS(2), DFFA(2), FAS(1), FASLG(1), GZMB(3), HELLS(3), IKBKB(2), IRF1(5), IRF2(2), IRF3(3), IRF4(4), IRF5(2), IRF6(4), IRF7(3), MAP3K1(9), MAPK10(1), MDM2(5), NFKB1(2), NFKBIA(3), NFKBIE(3), PLEKHG5(4), PRF1(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF21(2), TNFRSF25(2), TNFSF10(2), TP53(408), TRADD(1), TRAF1(1), TRAF2(2), TRAF3(1) 68081193 526 373 278 40 174 68 67 115 95 7 <1.00e-15 <1.00e-15 <2.37e-14 10 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(6), ATM(12), ATR(10), CCNA1(3), CCND1(4), CCNE1(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), DHFR(1), E2F1(1), GSK3B(1), RB1(30), SKP2(4), TFDP1(1), TGFB2(2), TGFB3(1), TP53(408) 35802895 503 365 253 13 147 54 70 106 118 8 <1.00e-15 <1.00e-15 <2.37e-14 11 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(13), DAXX(5), PAX3(4), PML(3), RB1(30), SIRT1(1), SP100(6), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TP53(408) 22687383 475 357 226 13 144 51 63 99 110 8 <1.00e-15 <1.00e-15 <2.37e-14 12 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), IFNG(2), IFNGR1(1), IFNGR2(4), IKBKB(2), JAK2(5), NFKB1(2), NFKBIA(3), RB1(30), RELA(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TP53(408), USH1C(3), WT1(3) 21657402 472 356 223 15 143 48 64 99 110 8 <1.00e-15 <1.00e-15 <2.37e-14 13 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(3), BAK1(2), BAX(1), BCL2(3), BIRC2(3), BIRC3(1), CASP2(1), CASP8(2), CASP9(1), CYCS(2), FAS(1), FASLG(1), GZMB(3), MAP3K1(9), MAPK10(1), MCL1(1), MDM2(5), NFKB1(2), NFKBIA(3), PARP1(3), PRF1(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFSF10(2), TP53(408), TRADD(1), TRAF1(1), TRAF2(2) 44453792 475 355 227 26 154 57 67 103 87 7 <1.00e-15 <1.00e-15 <2.37e-14 14 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(6), ATM(12), BRCA1(6), CDKN1A(2), CHEK1(6), CHEK2(3), MAPK8(2), MDM2(5), MRE11A(3), NFKB1(2), NFKBIA(3), RAD50(6), RBBP8(3), RELA(1), TP53(408) 35432909 468 350 222 20 152 54 67 102 86 7 <1.00e-15 <1.00e-15 <2.37e-14 15 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(12), CDC25A(1), CDC25B(1), CDK2(1), CDK4(1), CHEK1(6), MYT1(7), RB1(30), TP53(408), WEE1(2), YWHAH(2) 20919290 471 350 222 10 141 47 65 94 116 8 <1.00e-15 <1.00e-15 <2.37e-14 16 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(12), ATR(10), CHEK1(6), CHEK2(3), TP53(408), YWHAH(2) 19026549 441 339 195 10 141 51 65 94 83 7 <1.00e-15 <1.00e-15 <2.37e-14 17 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CCND1(4), CDK2(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CFL1(1), E2F1(1), E2F2(1), MDM2(5), PRB1(2), TP53(408) 9939716 437 338 190 7 142 47 63 91 87 7 <1.00e-15 <1.00e-15 <2.37e-14 18 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), DNAJC3(2), EIF2S2(2), NFKB1(2), NFKBIA(3), RELA(1), TP53(408) 11663393 419 331 173 8 138 47 59 90 78 7 <1.00e-15 <1.00e-15 <2.37e-14 19 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(3), AR(4), ASAH1(2), BRAF(12), CCL13(1), CCL15(1), CCL16(1), DAG1(3), EGFR(138), GNA11(1), GNA15(1), GNAI1(4), ITPR1(9), ITPR2(15), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), MAPK10(1), PHKA2(5), PIK3CA(83), PIK3CD(3), PIK3R1(56), PITX2(7), PTX3(2), RAF1(2), SRC(2) 63642072 388 265 256 41 50 103 62 100 70 3 <1.00e-15 <1.00e-15 <2.37e-14 20 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(3), EGF(10), EGFR(138), ELK1(5), FOS(2), JAK1(3), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), PIK3CA(83), PIK3R1(56), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(4), STAT3(3), STAT5A(1) 44556260 357 253 227 30 43 102 43 94 71 4 <1.00e-15 <1.00e-15 <2.37e-14 21 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), BPNT1(1), ILK(1), MAPK1(4), MAPK3(2), PDK1(2), PIK3CA(83), PIK3CD(3), PTEN(115), PTK2B(5), RBL2(3), SHC1(1), SOS1(7) 24213772 229 194 169 12 19 51 40 46 72 1 <1.00e-15 <1.00e-15 <2.37e-14 22 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), NTRK1(4), PIK3CA(83), PIK3R1(56), PLCG1(12), PRKCA(6), SHC1(1), SOS1(7) 18490390 171 149 118 10 13 31 36 31 58 2 4.73e-10 <1.00e-15 <2.37e-14 23 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(1), PAK1(3), PDGFRA(32), PIK3CA(83), PIK3R1(56), RAC1(1), WASL(2) 15909531 185 147 130 11 7 40 36 37 64 1 7.61e-10 <1.00e-15 <2.37e-14 24 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(83), PIK3R1(56), PLCB1(4), PLCG1(12), PRKCA(6), VAV1(9) 15238596 172 147 119 11 15 31 35 33 56 2 3.18e-09 <1.00e-15 <2.37e-14 25 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), CASP9(1), CHUK(1), GH1(2), GHR(4), NFKB1(2), NFKBIA(3), PIK3CA(83), PIK3R1(56), PPP2CA(4), RELA(1), YWHAH(2) 16742240 161 135 110 8 11 31 33 30 55 1 3.53e-10 <1.00e-15 <2.37e-14 26 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), CASP9(1), CHUK(1), ELK1(5), H2AFX(1), MAP2K1(1), MAPK3(2), NFKB1(2), PIK3CA(83), PIK3R1(56), RAC1(1), RAF1(2), RALA(2), RALBP1(3), RALGDS(5), RELA(1) 22713854 168 135 117 11 13 29 35 29 60 2 2.10e-09 <1.00e-15 <2.37e-14 27 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(3), ELK1(5), FOS(2), INSR(6), IRS1(8), MAP2K1(1), MAPK3(2), MAPK8(2), PIK3CA(83), PIK3R1(56), PTPN11(11), RAF1(2), RASA1(4), SHC1(1), SLC2A4(1), SOS1(7), SRF(3) 30308874 197 161 144 18 20 40 36 38 61 2 7.59e-09 1.11e-15 2.53e-14 28 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(5), G6PD(3), GCLC(1), GGT1(3), GPX1(1), GPX2(2), GPX4(2), GPX5(1), GPX6(1), GSS(2), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(3), GSTA5(4), GSTK1(2), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), IDH1(412), IDH2(20), OPLAH(3) 26139528 476 451 49 14 406 24 8 34 4 0 <1.00e-15 1.22e-15 2.59e-14 29 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(12), ATR(10), BRCA1(6), BRCA2(13), CHEK1(6), CHEK2(3), FANCA(4), FANCC(1), FANCD2(10), FANCE(2), HUS1(1), MRE11A(3), RAD1(2), RAD17(2), RAD50(6), RAD9A(2), TP53(408), TREX1(2) 52425598 493 362 246 18 154 64 75 106 87 7 <1.00e-15 1.22e-15 2.59e-14 30 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(3), ELK1(5), FOS(2), JAK1(3), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), PDGFA(1), PDGFRA(32), PIK3CA(83), PIK3R1(56), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(4), STAT3(3), STAT5A(1) 41504723 242 186 184 23 23 54 44 48 69 4 1.42e-10 1.33e-15 2.74e-14 31 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(2), CD3D(1), CD3E(2), CD3G(1), CD86(3), CTLA4(1), HLA-DRA(4), HLA-DRB1(1), ICOS(1), ITK(1), LCK(1), PIK3CA(83), PIK3R1(56), PTPN11(11) 15191606 168 144 114 9 13 31 34 34 55 1 6.85e-10 1.44e-15 2.82e-14 32 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(15), AKT1(2), ATM(12), BAX(1), CDKN1A(2), CPB2(1), CSNK1A1(2), CSNK1D(2), MAPK8(2), MDM2(5), NQO1(2), TP53(408) 24731543 454 348 207 16 147 51 63 100 86 7 <1.00e-15 1.55e-15 2.82e-14 33 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A1(7), EIF4A2(2), EIF4B(3), EIF4E(2), EIF4G1(5), EIF4G2(1), EIF4G3(7), MKNK1(2), PIK3CA(83), PIK3R1(56), PPP2CA(4), PTEN(115), RPS6KB1(2), TSC1(2), TSC2(6) 32818683 299 244 223 13 25 60 51 55 107 1 <1.00e-15 1.55e-15 2.82e-14 34 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), CHRNB1(2), CHRNG(3), MUSK(5), PIK3CA(83), PIK3R1(56), PTK2(2), PTK2B(5), RAPSN(1), SRC(2), TERT(5), YWHAH(2) 19435754 168 145 117 12 17 29 34 31 56 1 4.75e-09 1.55e-15 2.82e-14 35 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(3), ATM(12), BAX(1), BCL2(3), CCND1(4), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(2), E2F1(1), MDM2(5), RB1(30), TIMP3(2), TP53(408) 21569053 475 359 226 10 142 49 66 99 111 8 <1.00e-15 1.78e-15 3.04e-14 36 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(5), EGF(10), EGFR(138), MET(13), PDGFRA(32), PRKCA(6), SH3GLB1(3), SH3KBP1(5), SRC(2) 23053334 216 148 138 25 32 75 14 75 19 1 7.39e-11 1.78e-15 3.04e-14 37 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAK1(2), BAX(1), BFAR(1), BTK(3), CAD(8), CASP10(2), CASP8(2), CASP8AP2(1), CD7(3), CSNK1A1(2), DAXX(5), DEDD(1), DEDD2(2), DFFA(2), DIABLO(2), EGFR(138), EPHB2(5), FAF1(4), IL1A(1), MAP3K1(9), MAP3K5(4), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2), MET(13), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), NR0B2(1), PTPN13(4), RALBP1(3), RIPK1(4), ROCK1(4), SMPD1(1), TNFRSF6B(1), TP53(408), TPX2(7), TRAF2(2), TUFM(1) 86729386 682 452 359 47 195 130 86 160 104 7 <1.00e-15 1.89e-15 3.04e-14 38 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), CDKN1A(2), ELK1(5), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CA(83), PIK3CD(3), SHC1(1), SOS1(7) 19279309 110 91 75 9 13 26 25 22 24 0 8.86e-08 1.89e-15 3.04e-14 39 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(3), ATM(12), ATR(10), BAI1(4), BAX(1), CASP8(2), CASP9(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNG1(2), CCNG2(2), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(6), CHEK1(6), CHEK2(3), CYCS(2), DDB2(3), EI24(4), FAS(1), GADD45B(1), GTSE1(5), IGF1(3), MDM2(5), MDM4(2), PPM1D(4), PTEN(115), RCHY1(1), RFWD2(4), RPRM(1), RRM2(1), RRM2B(1), SERPINB5(3), SERPINE1(4), SESN1(2), SESN2(1), SESN3(2), SFN(3), SIAH1(3), STEAP3(2), THBS1(6), TP53(408), TP53I3(1), TSC2(6), ZMAT3(3) 77523045 673 455 400 44 169 92 100 148 157 7 <1.00e-15 2.00e-15 3.04e-14 40 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAPK1(4), MAPK3(2), NFKB1(2), PIK3CA(83), PIK3R1(56), RB1(30), RELA(1), SP1(1) 23104067 200 164 144 14 18 34 36 25 84 3 5.79e-10 2.00e-15 3.04e-14 41 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A1(7), EIF4A2(2), EIF4E(2), EIF4G1(5), EIF4G2(1), EIF4G3(7), GHR(4), IRS1(8), MAPK1(4), MAPK3(2), MKNK1(2), PABPC1(4), PIK3CA(83), PIK3R1(56), PRKCA(6), PTEN(115), RPS6KB1(2) 33406192 312 248 236 20 29 61 54 53 112 3 <1.00e-15 2.11e-15 3.04e-14 42 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(2), AKT1(2), BTK(3), CDKN2A(6), GSK3B(1), IARS(4), INPP5D(5), PDK1(2), PIK3CA(83), PPP1R13B(1), PTEN(115), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SOS1(7), SOS2(5), TEC(4), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1) 42709885 270 217 209 20 24 58 49 58 81 0 1.89e-15 2.11e-15 3.04e-14 43 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), APAF1(3), ATM(12), BAX(1), BCL2(3), CASP9(1), CYCS(2), PRKCA(6), PTK2(2), PXN(1), STAT1(4), TLN1(5), TP53(408) 32567355 450 346 204 11 143 48 64 102 84 9 <1.00e-15 2.22e-15 3.04e-14 44 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(7), SP1(1), SP3(5), TP53(408), WT1(3) 8380836 424 337 176 5 141 48 59 91 78 7 <1.00e-15 2.22e-15 3.04e-14 45 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(2), CFL1(1), LIMK1(4), MAP3K1(9), MYL2(2), MYLK(7), NCF2(5), PAK1(3), PDGFRA(32), PIK3CA(83), PIK3R1(56), PLD1(8), PPP1R12B(1), RAC1(1), RALBP1(3), RPS6KB1(2), TRIO(7), VAV1(9), WASF1(1) 41487374 236 174 179 21 24 47 48 46 70 1 4.36e-11 2.22e-15 3.04e-14 46 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), ATF2(2), DLD(3), DUSP10(2), DUSP4(1), GCK(2), IL1R1(4), MAP2K5(2), MAP3K1(9), MAP3K10(1), MAP3K11(1), MAP3K12(6), MAP3K13(3), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K7(3), MAP3K9(6), MAPK10(1), MAPK7(6), MAPK8(2), MAPK9(2), MYEF2(3), NFATC3(2), NR2C2(3), PAPPA(6), SHC1(1), TP53(408), ZAK(2) 59869709 496 356 248 33 162 62 74 107 84 7 <1.00e-15 2.33e-15 3.12e-14 47 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(10), EGFR(138), MAP2K1(1), MAP3K1(9), NCOR2(9), RXRA(4), THRA(5), THRB(2) 20548132 178 137 99 23 30 68 7 58 15 0 5.79e-09 2.44e-15 3.20e-14 48 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2S2(2), EIF2S3(2), EIF4E(2), GSK3B(1), IGF1(3), IGF1R(10), INPPL1(8), PIK3CA(83), PIK3R1(56), PPP2CA(4), PTEN(115), RPS6KB1(2) 23373772 290 239 214 8 19 54 52 54 110 1 <1.00e-15 2.55e-15 3.28e-14 49 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(2), GHR(4), INSR(6), IRS1(8), JAK2(5), MAP2K1(1), MAPK1(4), MAPK3(2), PIK3CA(83), PIK3R1(56), PLCG1(12), PRKCA(6), PTPN6(1), RAF1(2), RPS6KA1(5), SHC1(1), SLC2A4(1), SOCS1(1), SOS1(7), SRF(3), STAT5A(1), STAT5B(2) 39294707 213 171 160 25 23 41 42 41 63 3 1.63e-07 2.78e-15 3.42e-14 50 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(3), ELK1(5), FOS(2), IGF1(3), IGF1R(10), IRS1(8), MAP2K1(1), MAPK3(2), MAPK8(2), PIK3CA(83), PIK3R1(56), PTPN11(11), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3) 29471926 203 168 150 17 18 38 40 41 64 2 1.17e-09 2.78e-15 3.42e-14 51 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(12), ATR(10), BRCA1(6), CCNB1(2), CDC25A(1), CDC25B(1), CDC34(2), CDKN1A(2), CHEK1(6), CHEK2(3), EP300(6), MDM2(5), MYT1(7), PRKDC(14), RPS6KA1(5), TP53(408), WEE1(2), YWHAH(2), YWHAQ(1) 49854268 495 355 249 27 156 58 69 108 96 8 <1.00e-15 3.22e-15 3.81e-14 52 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(3), FOS(2), JAK2(5), MAP2K1(1), MAPK3(2), MPL(5), PIK3CA(83), PIK3R1(56), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), STAT1(4), STAT3(3), STAT5A(1), STAT5B(2), THPO(2) 35586006 201 165 148 14 22 35 38 40 62 4 1.16e-10 3.22e-15 3.81e-14 53 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(5), AKT1(2), CAMK2A(4), CAMK2D(1), CAMK2G(2), CREB1(2), GNAS(4), MAPK1(4), MAPK3(2), PIK3CA(83), PIK3R1(56), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), RAC1(1), RPS6KA1(5), RPS6KA5(2), SOS1(7) 34636917 191 156 140 13 27 31 38 31 61 3 3.92e-10 3.44e-15 3.83e-14 54 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(6), ACO2(4), CLYBL(5), DLD(3), FH(1), IDH1(412), IDH2(20), IDH3A(1), IDH3B(1), OGDH(1), OGDHL(7), PC(4), PCK1(6), SDHA(4), SDHC(2), SUCLA2(1), SUCLG1(2), SUCLG2(1) 35404065 485 451 57 16 404 22 10 44 5 0 <1.00e-15 3.55e-15 3.83e-14 55 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(6), ANAPC1(3), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC4(2), ANAPC5(5), ANAPC7(2), ATM(12), ATR(10), BUB1(5), BUB1B(2), BUB3(3), CCNA1(3), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNH(2), CDC14A(2), CDC14B(5), CDC16(2), CDC20(1), CDC23(4), CDC25A(1), CDC25B(1), CDC27(5), CDC6(1), CDC7(2), CDK2(1), CDK4(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), CDKN2C(6), CHEK1(6), CHEK2(3), CREBBP(13), CUL1(4), DBF4(6), E2F1(1), E2F2(1), E2F3(1), EP300(6), ESPL1(8), FZR1(4), GADD45B(1), GSK3B(1), HDAC2(7), MAD1L1(1), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), PKMYT1(1), PLK1(2), PRKDC(14), RB1(30), RBL1(6), RBL2(3), RBX1(1), SFN(3), SKP2(4), SMAD2(3), SMAD3(3), SMAD4(1), SMC1A(11), SMC1B(9), TFDP1(1), TGFB2(2), TGFB3(1), TP53(408), WEE1(2), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1) 161629493 734 433 484 81 181 101 104 175 162 11 <1.00e-15 3.55e-15 3.83e-14 56 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCND1(4), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(2), CDKN1B(4), E2F1(1), MAPK1(4), MAPK3(2), NFKB1(2), NFKBIA(3), PAK1(3), PIK3CA(83), PIK3R1(56), RAC1(1), RAF1(2), RB1(30), RELA(1), TFDP1(1) 24042611 205 165 150 10 15 30 39 29 89 3 7.39e-13 3.55e-15 3.83e-14 57 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(10), EGFR(138), HGS(3), TF(2), TFRC(2) 15260476 158 122 83 17 23 62 6 58 9 0 1.63e-08 3.55e-15 3.83e-14 58 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(12), CCNA1(3), CCNB1(2), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNG2(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), CDKN2C(6), CREB3(3), CREB3L1(2), CREB3L3(4), CREB3L4(1), E2F1(1), E2F2(1), E2F3(1), E2F4(1), E2F5(1), E2F6(1), GBA2(1), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), MYT1(7), NACA(6), POLA2(2), POLE(8), POLE2(1), PRIM1(2), RB1(30), RBL1(6), RPA1(3), RPA2(1), TFDP1(1), TNXB(14), TP53(408), WEE1(2) 91696536 593 397 343 46 162 62 81 131 149 8 <1.00e-15 3.66e-15 3.83e-14 59 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(10), EGFR(138), ERBB3(4), NRG1(5) 12239698 157 122 82 14 24 61 4 56 12 0 1.03e-09 3.66e-15 3.83e-14 60 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(5), AKT1(2), BAX(1), BCL2(3), CSF2RB(6), IGF1(3), IGF1R(10), IL3(2), IL3RA(4), KIT(9), KITLG(3), PIK3CA(83), PIK3R1(56), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), YWHAH(2) 26062732 194 158 142 14 24 30 40 37 62 1 1.87e-10 3.77e-15 3.88e-14 61 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(3), CDKN1B(4), ILK(1), ITGB1(3), MAPK1(4), MAPK3(2), PIK3CA(83), PIK3R1(56), PTEN(115), PTK2(2), SHC1(1), SOS1(7) 22950702 283 233 207 5 19 53 51 49 109 2 <1.00e-15 3.89e-15 3.92e-14 62 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(3), CREBBP(13), EP300(6), FYN(2), IL7(1), IL7R(3), JAK1(3), JAK3(5), LCK(1), PIK3CA(83), PIK3R1(56), PTK2B(5), STAT5A(1), STAT5B(2) 33306757 184 153 133 20 17 33 36 35 62 1 1.53e-06 4.00e-15 3.95e-14 63 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 CRKL(2), DOCK1(3), ELK1(5), FOS(2), HGF(4), ITGA1(4), ITGB1(3), MAP2K1(1), MAP2K2(1), MAP4K1(3), MAPK1(4), MAPK3(2), MAPK8(2), MET(13), PAK1(3), PIK3CA(83), PIK3R1(56), PTEN(115), PTK2(2), PTK2B(5), PTPN11(11), PXN(1), RAF1(2), RASA1(4), SOS1(7), SRC(2), STAT3(3) 52409065 343 259 264 24 36 63 56 69 117 2 <1.00e-15 4.11e-15 3.95e-14 64 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), IGF1R(10), IRS1(8), MAP2K1(1), MAPK1(4), MAPK3(2), PIK3CA(83), PIK3R1(56), RAF1(2), SHC1(1), SOS1(7), YWHAH(2) 22512281 178 150 127 11 14 32 39 29 62 2 2.36e-10 4.11e-15 3.95e-14 65 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(2), ANXA1(2), CALM1(1), CALM3(1), GNAS(4), GNB1(1), NFKB1(2), NOS3(10), NPPA(2), NR3C1(3), PIK3CA(83), PIK3R1(56), RELA(1), SYT1(2) 21358575 171 143 120 11 21 30 35 29 55 1 6.10e-09 4.33e-15 4.10e-14 66 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), HLA-A(1), IL18(3), ITGB1(3), KLRC1(3), KLRC2(5), KLRD1(1), LAT(2), MAP2K1(1), MAPK3(2), PAK1(3), PIK3CA(83), PIK3R1(56), PTK2B(5), PTPN6(1), RAC1(1), VAV1(9) 22130578 180 143 128 15 17 30 36 32 63 2 3.37e-08 4.44e-15 4.14e-14 67 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(2), BRD4(1), CBL(2), CDKN2A(6), FLOT1(2), FLOT2(3), GSK3B(1), INPPL1(8), IRS1(8), IRS2(1), IRS4(7), LNPEP(3), MAPK1(4), MAPK3(2), PARD3(3), PARD6A(1), PDK1(2), PIK3CA(83), PIK3CD(3), PIK3R1(56), PPYR1(1), PTEN(115), PTPN1(1), RAF1(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SLC2A4(1), SORBS1(3), SOS1(7), SOS2(5), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1) 70612038 363 269 286 29 32 65 63 75 126 2 <1.00e-15 4.55e-15 4.19e-14 68 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(5), AKT1(2), ASAH1(2), GNAI1(4), GNB1(1), ITGAV(3), ITGB3(4), MAPK1(4), MAPK3(2), PDGFA(1), PDGFRA(32), PIK3CA(83), PIK3R1(56), PLCB1(4), PRKCA(6), PTK2(2), RAC1(1), SMPD1(1), SMPD2(1), SRC(2) 32614937 216 161 162 19 19 44 46 40 64 3 2.56e-10 5.55e-15 5.03e-14 69 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCL2(3), BCR(3), CRKL(2), FOS(2), JAK2(5), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), PIK3CA(83), PIK3R1(56), RAF1(2), SOS1(7), STAT1(4), STAT5A(1), STAT5B(2) 33365015 186 152 133 14 16 37 37 34 59 3 5.91e-10 5.88e-15 5.20e-14 70 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CXCR4(2), GNAI1(4), GNB1(1), MAP2K1(1), MAPK1(4), MAPK3(2), NFKB1(2), PIK3C2G(10), PIK3CA(83), PIK3R1(56), PLCG1(12), PRKCA(6), PTK2(2), PTK2B(5), PXN(1), RAF1(2), RELA(1) 32902760 197 165 144 24 24 31 44 34 61 3 1.07e-06 6.00e-15 5.20e-14 71 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(3), ELK1(5), FOS(2), MAP2K1(1), MAPK3(2), MAPK8(2), NGFR(1), PIK3CA(83), PIK3R1(56), PLCG1(12), RAF1(2), SHC1(1), SOS1(7) 22718289 177 150 124 9 13 35 36 32 59 2 1.43e-11 6.00e-15 5.20e-14 72 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(5), ARHGEF1(1), F2(4), F2R(2), F2RL3(3), GNA13(1), GNAI1(4), GNB1(1), MAP3K7(3), PIK3CA(83), PIK3R1(56), PLCB1(4), PPP1R12B(1), PRKCA(6), PTK2B(5), ROCK1(4) 30753627 183 146 132 21 21 32 37 32 59 2 1.25e-06 6.33e-15 5.41e-14 73 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(2), MAPK1(4), MAPK3(2), MAPK7(6), MEF2A(4), MEF2B(1), MEF2D(1), NTRK1(4), PIK3CA(83), PIK3R1(56), PLCG1(12), RPS6KA1(5), SHC1(1) 22523702 183 154 130 15 14 36 36 32 63 2 5.51e-09 6.44e-15 5.43e-14 74 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(3), GH1(2), GHR(4), IGF1(3), IGF1R(10), PIK3CA(83), PIK3R1(56), SHC1(1), SOD2(1) 15813522 165 142 114 6 11 31 36 30 56 1 2.25e-12 7.22e-15 6.01e-14 75 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(3), AXIN1(4), CCND1(4), CD14(1), CTNNB1(3), DVL1(1), FZD1(3), GJA1(5), GNAI1(4), GSK3B(1), IRAK1(3), LBP(5), LEF1(1), LY96(2), NFKB1(2), PIK3CA(83), PIK3R1(56), PPP2CA(4), RELA(1), TLR4(2), TOLLIP(1), WNT1(1) 36581308 192 156 141 20 23 35 41 33 59 1 7.96e-08 1.03e-14 8.48e-14 76 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(1), AGT(3), AGTR2(4), EDNRA(1), EDNRB(1), EGF(10), EGFR(138), FOS(2), NFKB1(2), PLCG1(12), PRKCA(6), RELA(1) 24365042 181 134 104 27 29 65 9 67 10 1 6.47e-08 6.18e-14 5.01e-13 77 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), CABIN1(11), CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), HDAC5(1), IGF1(3), IGF1R(10), INSR(6), MAPK7(6), MEF2A(4), MEF2B(1), MEF2D(1), MYOD1(1), NFATC1(2), NFATC2(7), PIK3CA(83), PIK3R1(56), PPP3CA(1), PPP3CB(2), PPP3CC(1), SYT1(2), YWHAH(2) 41380952 207 166 156 26 26 37 42 38 63 1 2.35e-07 7.25e-13 5.80e-12 78 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(3), CALM1(1), CALM3(1), ELK1(5), FCER1A(4), FOS(2), LYN(2), MAP2K1(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PAK2(2), PIK3CA(83), PIK3R1(56), PLA2G4A(7), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), RAF1(2), SHC1(1), SOS1(7), SYT1(2), VAV1(9) 51166922 237 179 182 27 27 48 47 49 64 2 2.31e-09 8.33e-13 6.58e-12 79 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(5), DIAPH1(5), FYN(2), GSN(2), ITGA1(4), ITGB1(3), MAP2K1(1), MAPK1(4), MAPK3(2), MYL2(2), MYLK(7), PIK3CA(83), PIK3R1(56), PTK2(2), PXN(1), RAF1(2), ROCK1(4), SHC1(1), SRC(2), TLN1(5) 44376154 193 154 141 18 21 29 42 39 60 2 2.75e-08 8.74e-13 6.82e-12 80 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2), MAPKAPK5(2), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PIK3CA(83), PIK3CD(3), PIK3R1(56), SYT1(2), TRAF2(2), TRAF3(1), TRAF5(3) 39959664 191 151 140 20 25 34 40 31 59 2 4.24e-08 1.25e-12 9.65e-12 81 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), AGTR1(1), ATF2(2), CALM1(1), CALM3(1), EGFR(138), ELK1(5), MAP2K1(1), MAP2K2(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), MEF2A(4), MEF2B(1), MEF2D(1), PAK1(3), PRKCA(6), PTK2(2), PTK2B(5), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SRC(2), SYT1(2) 39869497 207 149 129 24 31 75 14 64 21 2 3.72e-11 9.60e-12 7.30e-11 82 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(2), BCL2(3), GSK3B(1), IL4R(9), IRS1(8), IRS2(1), JAK1(3), JAK3(5), MAP4K1(3), MAPK1(4), MAPK3(2), PDK1(2), PIK3CA(83), PIK3CD(3), PIK3R1(56), PPP1R13B(1), RAF1(2), SHC1(1), SOCS1(1), SOS1(7), SOS2(5), STAT6(5) 43425123 207 164 156 24 23 34 38 45 65 2 5.93e-07 6.91e-11 5.19e-10 83 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CALM3(1), CD3D(1), CD3E(2), CD3G(1), ELK1(5), FOS(2), FYN(2), LAT(2), LCK(1), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKBIA(3), PIK3CA(83), PIK3R1(56), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKCA(6), PTPN7(2), RAC1(1), RAF1(2), RASA1(4), RELA(1), SHC1(1), SOS1(7), SYT1(2), VAV1(9), ZAP70(8) 56853226 251 186 196 28 39 45 45 50 69 3 2.96e-10 9.66e-11 7.14e-10 84 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(2), EGF(10), EGFR(138), MAP2K1(1), MAPK1(4), MAPK3(2), PTPRB(9), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SPRY1(1), SPRY2(3), SPRY3(3), SPRY4(3), SRC(2) 29646392 192 145 117 27 31 63 11 66 20 1 1.77e-07 9.73e-11 7.14e-10 85 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(3), CCNE1(2), CDC34(2), CDK2(1), CUL1(4), E2F1(1), RB1(30), SKP2(4), TFDP1(1) 10174246 48 44 45 3 2 4 4 7 30 1 0.00256 1.31e-10 9.52e-10 86 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(2), CDK2(1), CDKN1B(4), CUL1(4), E2F1(1), RB1(30), RBX1(1), SKP2(4), TFDP1(1), UBE2M(2) 10190009 50 45 47 4 1 5 5 6 32 1 0.00390 1.49e-10 1.07e-09 87 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), ARHGAP1(1), ARHGAP4(4), ARHGEF11(4), BTK(3), CFL1(1), CFL2(2), GDI1(4), GDI2(1), INPPL1(8), ITPR1(9), ITPR2(15), ITPR3(18), LIMK1(4), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PDK1(2), PIK3CA(83), PIK3CD(3), PIK3CG(12), PIK3R1(56), PITX2(7), PPP1R13B(1), PTEN(115), ROCK1(4), ROCK2(5), RPS4X(3), SAG(2), WASF1(1), WASL(2) 83522111 405 287 327 48 60 82 67 74 120 2 1.30e-14 4.80e-10 3.40e-09 88 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(2), BCL2(3), CBL(2), CFLAR(1), CRKL(2), E2F1(1), FOS(2), IL2RB(2), IRS1(8), JAK1(3), JAK3(5), MAPK1(4), MAPK3(2), PIK3CA(83), PIK3R1(56), PTPN6(1), RAF1(2), RPS6KB1(2), SHC1(1), SOCS1(1), SOS1(7), STAT5A(1), STAT5B(2) 43013940 193 158 142 24 18 35 38 36 64 2 4.73e-06 5.14e-10 3.60e-09 89 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(2), CDC34(2), CDK2(1), CUL1(4), E2F1(1), FBXW7(6), RB1(30), TFDP1(1) 9845282 47 42 44 3 4 4 2 6 30 1 0.00276 6.60e-10 4.57e-09 90 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), BCR(3), BTK(3), CD19(2), CDKN2A(6), FLOT1(2), FLOT2(3), ITPR1(9), ITPR2(15), ITPR3(18), LYN(2), NR0B2(1), PDK1(2), PHF11(1), PIK3CA(83), PITX2(7), PLCG2(12), PPP1R13B(1), PREX1(10), PTEN(115), PTPRC(9), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SAG(2), TEC(4), VAV1(9) 65693726 337 248 276 43 58 69 55 67 87 1 2.44e-13 2.34e-09 1.60e-08 91 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(1), RB1(30), SP1(1), SP3(5) 7904873 38 35 35 3 1 1 3 3 29 1 0.0378 5.30e-09 3.59e-08 92 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(3), AKT1(2), CALM1(1), CALM3(1), CALR(2), CAMK1(2), CAMK1G(1), CAMK4(3), CREBBP(13), CSNK1A1(2), ELSPBP1(3), F2(4), GATA4(3), GSK3B(1), IGF1(3), MAP2K1(1), MAPK1(4), MAPK3(2), MAPK8(2), MYH2(25), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NPPA(2), PIK3CA(83), PIK3R1(56), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RAF1(2), RPS6KB1(2), SYT1(2) 60364684 250 182 198 29 44 37 46 52 69 2 9.48e-10 8.53e-09 5.71e-08 93 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), CISH(1), IARS(4), IL13RA1(3), IL4R(9), INPP5D(5), JAK1(3), JAK2(5), JAK3(5), NR0B2(1), PI3(2), PIK3CA(83), PPP1R13B(1), RPS6KB1(2), SERPINA4(2), SHC1(1), SOS1(7), SOS2(5), SRC(2), STAT6(5), TYK2(10) 43909598 158 124 123 12 30 29 31 39 29 0 2.37e-10 1.71e-07 1.13e-06 94 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(3), CCNB1(2), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), CDKN2C(6), E2F1(1), RB1(30), RBL1(6), TFDP1(1) 18997024 78 65 74 7 7 5 9 14 42 1 0.000551 3.32e-07 2.17e-06 95 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(138), ELK1(5), GNAS(4), GNB1(1), IGF1R(10), ITGB1(3), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MKNK1(2), NGFR(1), PDGFRA(32), PPP2CA(4), PTPRR(6), RAF1(2), RPS6KA1(5), RPS6KA5(2), SHC1(1), SOS1(7), SRC(2), STAT3(3) 39383221 236 166 158 30 36 80 18 77 24 1 1.01e-10 1.00e-06 6.50e-06 96 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), FURIN(1), NOTCH1(52), PSEN1(1) 11110162 55 44 43 5 5 8 2 12 25 3 0.0181 2.63e-06 1.69e-05 97 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(12), CPEB1(4), EGFR(138), ERBB2(3), ERBB4(5), ETS1(5), ETV6(4), ETV7(1), FMN2(3), KRAS(5), MAP2K1(1), MAPK1(4), MAPK3(2), NOTCH1(52), NOTCH2(16), NOTCH3(7), NOTCH4(10), PIWIL1(2), PIWIL2(5), PIWIL3(5), PIWIL4(2), RAF1(2), SOS1(7), SOS2(5), SPIRE1(2), SPIRE2(3) 62267087 305 215 209 38 49 88 24 92 47 5 1.23e-11 7.52e-06 4.78e-05 98 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(3), APC2(3), AXIN1(4), AXIN2(2), BTRC(2), CACYBP(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CCND1(4), CCND2(2), CCND3(1), CHD8(11), CREBBP(13), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(3), CSNK2B(3), CTBP1(5), CTBP2(4), CTNNB1(3), CUL1(4), CXXC4(2), DAAM1(1), DAAM2(3), DKK1(2), DKK2(5), DKK4(2), DVL1(1), DVL2(3), DVL3(3), EP300(6), FBXW11(1), FZD1(3), FZD10(5), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GSK3B(1), LEF1(1), LRP5(7), LRP6(9), MAP3K7(3), MAPK10(1), MAPK8(2), MAPK9(2), MMP7(2), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NKD1(2), NKD2(4), NLK(1), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PORCN(8), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRICKLE1(2), PRICKLE2(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PSEN1(1), RAC1(1), RAC2(1), RBX1(1), ROCK1(4), ROCK2(5), RUVBL1(3), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(1), SIAH1(3), SMAD2(3), SMAD3(3), SMAD4(1), SOX17(4), TBL1X(1), TBL1XR1(3), TBL1Y(1), TCF7L2(5), TP53(408), VANGL1(2), VANGL2(2), WIF1(3), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2(8), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2) 192447230 742 443 494 107 245 89 97 163 140 8 <1.00e-15 1.19e-05 7.47e-05 99 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(2), CDK2(1), CDKN1B(4), CDKN2A(6), CREB1(2), CREB3(3), ERBB4(5), GSK3B(1), IGF1(3), INPPL1(8), IRS1(8), IRS2(1), IRS4(7), MET(13), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PARD3(3), PARD6A(1), PDK1(2), PIK3CA(83), PIK3CD(3), PPP1R13B(1), PREX1(10), PTEN(115), PTK2(2), PTPN1(1), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SLC2A4(1), SOS1(7), SOS2(5), TSC1(2), TSC2(6), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1) 91724750 355 259 293 40 45 66 65 79 100 0 4.00e-14 4.72e-05 0.000294 100 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(2), ATF1(1), BRAF(12), CREB1(2), CREB3(3), CREBBP(13), CRKL(2), DAG1(3), EGR1(5), EGR2(2), EGR3(2), ELK1(5), FRS2(1), MAP1B(10), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2), NTRK1(4), OPN1LW(1), PIK3C2G(10), PIK3CA(83), PIK3CD(3), PIK3R1(56), PTPN11(11), RPS6KA3(4), SHC1(1), SRC(2), TERF2IP(1), TH(3) 61260153 268 198 208 36 34 45 52 60 75 2 3.36e-08 6.17e-05 0.000380 101 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(2), CAPNS1(2), CAPNS2(1), EGF(10), EGFR(138), ITGA1(4), ITGB1(3), MAPK1(4), MAPK3(2), MYL2(2), MYLK(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTK2(2), PXN(1), TLN1(5) 38893517 188 137 113 29 35 61 14 66 11 1 1.34e-07 0.000105 0.000640 102 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF2B1(1), EIF2B4(1), EIF2S2(2), EIF2S3(2), ELAVL1(1), FLT1(10), FLT4(8), KDR(14), NOS3(10), PIK3CA(83), PIK3R1(56), PLCG1(12), PRKCA(6), PTK2(2), PXN(1), SHC1(1) 40456738 211 170 158 34 27 38 42 41 61 2 6.37e-05 0.000842 0.00509 103 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), BRAF(12), CAB39(2), EIF4B(3), FIGF(2), IGF1(3), MAPK1(4), MAPK3(2), PGF(1), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PRKAA1(3), PRKAA2(2), RICTOR(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(3), STK11(1), TSC1(2), TSC2(6), ULK1(2), ULK2(7), VEGFA(4), VEGFB(3), VEGFC(3) 63327013 261 191 203 31 40 44 49 59 67 2 5.06e-09 0.00100 0.00601 104 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(3), CCNA2(1), CCND1(4), CCNE1(2), CCNE2(2), CDK2(1), CDK4(1), CDKN1B(4), CDKN2A(6), E2F1(1), E2F2(1), E2F4(1), PRB1(2) 10572211 29 25 28 1 5 1 6 7 10 0 0.00211 0.00819 0.0485 105 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(13), GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), GABRA6(15), GPX1(1), PRKCE(1) 9381138 51 45 48 10 13 10 7 16 5 0 0.0235 0.0267 0.157 106 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(8), IFNG(2), IL12B(4), IL18(3) 3542953 17 13 17 3 4 3 2 6 2 0 0.182 0.0488 0.282 107 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(3) 2399460 9 9 9 2 4 3 0 1 1 0 0.348 0.0490 0.282 108 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(6), ABL2(3), AKT1(2), ARAF(1), AREG(3), BRAF(12), BTC(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CBL(2), CBLB(3), CBLC(2), CDKN1A(2), CDKN1B(4), CRKL(2), EGF(10), EGFR(138), ELK1(5), ERBB2(3), ERBB3(4), ERBB4(5), EREG(1), GSK3B(1), HBEGF(1), KRAS(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(2), NCK1(2), NRAS(5), NRG1(5), NRG2(1), NRG4(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PRKCA(6), PRKCG(4), PTK2(2), RAF1(2), RPS6KB1(2), RPS6KB2(3), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), SRC(2), STAT5A(1), STAT5B(2), TGFA(4) 122516194 509 319 370 72 85 120 67 137 97 3 <1.00e-15 0.0608 0.347 109 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(3) 854859 3 3 3 1 2 1 0 0 0 0 0.562 0.108 0.611 110 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1), CD3E(2), CD3G(1) 1351852 4 4 4 1 0 1 1 1 1 0 0.574 0.122 0.682 111 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), DAG1(3), DGKA(4), GCA(1), ITGA9(2), ITPR1(9), ITPR2(15), ITPR3(18), MAP2K1(1), MAPK1(4), MAPK3(2), NR1I3(1), PAK1(3), PDE3A(5), PDE3B(3), PI3(2), PIK3C2G(10), PIK3CA(83), PIK3CD(3), PIK3R1(56), PSME1(3), RIPK3(1), RPS4X(3), SGCB(1), VASP(1) 57985621 242 188 189 39 35 43 51 41 69 3 3.84e-06 0.132 0.732 112 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACPP(4), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(3), TYR(5) 11508628 22 19 22 1 8 2 4 6 2 0 0.00987 0.136 0.748 113 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), CD4(2), HLA-DRA(4), HLA-DRB1(1) 2824898 9 7 8 1 4 1 0 3 1 0 0.158 0.180 0.983 114 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(3), HGD(5) 2645677 10 6 10 2 4 0 1 2 3 0 0.308 0.189 1.000 115 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(2), GALT(1), TGDS(2), UGDH(1), UXS1(4) 4580573 10 9 10 1 1 2 3 2 2 0 0.162 0.195 1.000 116 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(2), CCL5(1), CCR3(2), CSF2(2), HLA-DRA(4), HLA-DRB1(1), IL3(2), IL5(1) 3611520 15 11 15 3 4 3 1 4 3 0 0.226 0.219 1.000 117 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(3), AXIN1(4), BTRC(2), CTNNB1(3), DLL1(1), DVL1(1), FZD1(3), GSK3B(1), NOTCH1(52), PSEN1(1), WNT1(1) 25546600 72 57 60 12 7 10 4 18 30 3 0.158 0.228 1.000 118 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPP5B(4), INPP5E(1), INPPL1(8), IPMK(2), ISYNA1(2), ITGB1BP3(1), ITPK1(3), MINPP1(1), MIOX(1), OCRL(7), PI4KA(8), PI4KB(4), PIK3C3(2), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(5), PTEN(115), PTPMT1(1), SYNJ1(6), SYNJ2(12) 88347955 367 258 305 54 62 74 54 83 94 0 6.24e-11 0.267 1.000 119 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(3), GGPS1(1), IDI1(2), IDI2(1), SQLE(1) 5066632 9 8 9 0 1 0 5 1 2 0 0.0921 0.341 1.000 120 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), BCR(3), BLNK(2), BTK(3), CD19(2), CSK(2), DAG1(3), EPHB2(5), LYN(2), MAP2K1(1), MAP2K2(1), MAPK1(4), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PI3(2), PIK3CA(83), PIK3CD(3), PIK3R1(56), PLCG2(12), PPP1R13B(1), RAF1(2), SERPINA4(2), SHC1(1), SOS1(7), SOS2(5), VAV1(9) 62578912 226 172 175 35 35 43 42 43 62 1 3.73e-06 0.344 1.000 121 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(2), COQ5(3), COQ6(2), NDUFA12(1), NDUFB11(1) 4785378 10 8 10 1 2 4 0 2 2 0 0.184 0.346 1.000 122 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(3), IDI1(2), SQLE(1) 3785468 7 6 7 0 1 0 4 0 2 0 0.163 0.367 1.000 123 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(3) 2158410 5 5 5 1 3 1 0 1 0 0 0.461 0.381 1.000 124 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(2), GALT(1), TGDS(2), UGDH(1), UGP2(1), UXS1(4) 5827733 11 9 11 1 1 2 3 3 2 0 0.139 0.388 1.000 125 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5), SUCLA2(1) 2508918 6 5 6 0 2 2 0 2 0 0 0.133 0.393 1.000 126 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), ASAH1(2), BRAF(12), DAG1(3), DRD2(1), EGFR(138), EPHB2(5), ITPR1(9), ITPR2(15), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), PI3(2), PIK3CB(7), PITX2(7), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), RAF1(2), SHC1(1), SOS1(7), SOS2(5), SRC(2), STAT3(3), TERF2IP(1) 69642177 273 179 192 37 52 82 29 91 18 1 2.62e-12 0.397 1.000 127 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(2), CCR3(2), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL1B(3), IL5(1), IL5RA(3), IL6(2) 6346628 20 15 20 4 6 4 0 8 2 0 0.137 0.451 1.000 128 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(3), NR0B2(1), NR1H3(5), NR1H4(3), RXRA(4) 6471064 18 17 16 4 7 4 2 4 1 0 0.138 0.456 1.000 129 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(1), BRAF(12), CREB1(2), CREB3(3), MAPK1(4), RAF1(2), SNX13(1), SRC(2), TERF2IP(1) 13323466 30 23 24 4 2 3 6 12 7 0 0.0858 0.494 1.000 130 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(12), RANGAP1(2) 9998529 15 13 15 1 3 2 3 5 2 0 0.0379 0.503 1.000 131 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(5), TPI1(1) 1956213 6 3 6 0 0 3 1 2 0 0 0.133 0.503 1.000 132 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP6(2), ACPP(4), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(3), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), TYR(5) 17839871 35 29 35 4 11 5 7 8 4 0 0.0149 0.532 1.000 133 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), BTK(3), CSF2(2), FCER1A(4), FYN(2), GAB2(3), IL3(2), IL5(1), INPP5D(5), KRAS(5), LAT(2), LCP2(1), LYN(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK9(2), NRAS(5), PDK1(2), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCG1(12), PLCG2(12), PRKCA(6), PRKCD(3), PRKCE(1), RAC1(1), RAC2(1), RAF1(2), SOS1(7), SOS2(5), TNF(1), VAV1(9), VAV2(4), VAV3(3) 85767055 321 227 263 59 61 59 57 66 75 3 2.08e-06 0.532 1.000 134 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(1), TAT(3) 3119700 6 5 5 1 3 1 1 1 0 0 0.366 0.534 1.000 135 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(5), GOT1(2), GOT2(1), TAT(3), TYR(5) 5582938 16 12 15 3 8 1 3 4 0 0 0.216 0.555 1.000 136 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(4), FH(1), IDH2(20), OGDH(1), SDHA(4), SUCLA2(1) 11149542 31 29 13 8 4 13 6 7 1 0 0.107 0.563 1.000 137 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(3), CASP8(2), CFL1(1), CFLAR(1) 4596535 7 6 7 0 0 1 1 2 3 0 0.194 0.576 1.000 138 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(2), APOA1(1), CD36(5), CITED2(1), CREBBP(13), DUSP1(1), EHHADH(2), EP300(6), FABP1(1), HSD17B4(3), LPL(2), MAPK1(4), MAPK3(2), ME1(2), NCOA1(3), NCOR1(9), NCOR2(9), NFKBIA(3), NR0B2(1), NR1H3(5), NR2F1(1), NRIP1(4), PDGFA(1), PIK3CA(83), PIK3R1(56), PPARA(4), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PTGS2(3), RB1(30), RELA(1), RXRA(4), SP1(1), STAT5A(1), STAT5B(2), TNF(1) 75200035 278 209 222 43 38 44 43 49 99 5 1.91e-06 0.587 1.000 139 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(9), PDXK(1), PSAT1(4) 5756041 14 11 12 4 7 5 0 2 0 0 0.257 0.665 1.000 140 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPP(7), ALPPL2(6), DHFR(1), FPGS(2), GGH(1), SPR(1) 7761312 20 18 18 5 10 3 4 1 2 0 0.152 0.668 1.000 141 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), BCL2(3), BCR(3), BLNK(2), BTK(3), CD19(2), CD22(10), CD81(2), CR2(8), CSK(2), DAG1(3), FLOT1(2), FLOT2(3), GSK3B(1), INPP5D(5), ITPR1(9), ITPR2(15), ITPR3(18), LYN(2), MAP4K1(3), MAPK1(4), MAPK3(2), NFATC1(2), NFATC2(7), NR0B2(1), PDK1(2), PIK3CA(83), PIK3CD(3), PIK3R1(56), PLCG2(12), PPP1R13B(1), PPP3CA(1), PPP3CB(2), PPP3CC(1), PTPRC(9), RAF1(2), SHC1(1), SOS1(7), SOS2(5), VAV1(9) 87939999 308 216 257 56 66 54 49 64 72 3 8.49e-07 0.672 1.000 142 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), BCKDK(3), CBS(5), CTH(2), MUT(2) 5829980 14 8 14 1 3 5 1 4 1 0 0.0414 0.673 1.000 143 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(3), CHUK(1), DAXX(5), EGF(10), EGFR(138), ETS1(5), FOS(2), HOXA7(2), IKBKB(2), MAP2K1(1), MAP2K3(6), MAP3K1(9), MAP3K5(4), MAPK1(4), MAPK13(2), MAPK3(2), MAPK8(2), NFKB1(2), NFKBIA(3), PPP2CA(4), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCQ(4), RAF1(2), RELA(1), RIPK1(4), SP1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRAF2(2) 58349424 244 174 165 41 50 80 18 69 24 3 3.52e-09 0.686 1.000 144 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD58(2), CD8A(1), IL3(2), IL6(2), KITLG(3) 7347641 18 13 18 3 3 2 2 8 3 0 0.143 0.702 1.000 145 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CDO1(1), CSAD(1), GAD1(3), GAD2(1), GGT1(3) 6836871 10 8 10 0 2 4 2 2 0 0 0.0224 0.711 1.000 146 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(2), NR3C1(3), PPARG(3), RETN(1), RXRA(4), TNF(1) 6893647 16 15 16 5 4 4 1 5 2 0 0.375 0.756 1.000 147 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(13), GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), GABRA6(15), GPHN(1), NSF(2), SRC(2), UBQLN1(2) 14212760 57 47 54 16 13 14 7 16 7 0 0.172 0.773 1.000 148 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(5), ALDOA(1), ALDOB(2), TPI1(1) 4641983 9 5 9 1 0 4 1 3 1 0 0.204 0.778 1.000 149 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), CASP9(1), KDR(14), KRAS(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK12(2), MAPK13(2), MAPK3(2), MAPKAPK2(2), MAPKAPK3(2), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NOS3(10), NRAS(5), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCG1(12), PLCG2(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKCA(6), PRKCG(4), PTGS2(3), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), SH2D2A(1), SHC2(1), SRC(2), VEGFA(4) 85721595 319 224 262 57 61 57 55 67 76 3 1.97e-07 0.797 1.000 150 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(2), ALDH1A2(2), BCMO1(1), RDH5(1) 4624958 6 6 6 2 2 4 0 0 0 0 0.419 0.820 1.000 151 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(3), GNB1(1), HTR2C(4), PLCB1(4), TUB(4) 8492989 16 13 16 4 5 3 0 6 2 0 0.352 0.823 1.000 152 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD3E(2), CD3G(1), CD4(2), FYN(2), HLA-DRA(4), HLA-DRB1(1), LCK(1), PTPRC(9), ZAP70(8) 10746799 31 24 31 8 11 5 3 10 2 0 0.234 0.825 1.000 153 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), IL6(2), LDLR(3), LPL(2) 6327852 8 8 8 2 0 1 0 7 0 0 0.620 0.833 1.000 154 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(1), CDK7(1), CDKN1A(2), CHEK1(6), NEK1(4), WEE1(2) 8250713 17 15 17 4 5 4 2 4 2 0 0.488 0.840 1.000 155 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS1(2), ALAS2(1), FECH(2), HMBS(1), PPOX(2), UROD(1), UROS(1) 9006522 12 9 12 1 2 3 2 4 1 0 0.0953 0.844 1.000 156 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2) 3817233 9 8 8 3 4 1 1 2 1 0 0.490 0.846 1.000 157 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(9), CD38(1), ENPP1(5), ENPP3(2), NADSYN1(5), NMNAT1(1), NMNAT2(1), NNMT(1), NNT(6), NT5C(3), NT5E(3), NT5M(1) 17273748 38 28 36 6 8 12 6 9 3 0 0.0111 0.849 1.000 158 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(3), CHRNA1(4) 3862566 7 7 7 3 2 2 1 1 1 0 0.585 0.857 1.000 159 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(1), FUT8(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3) 9345226 17 16 17 4 6 2 3 3 3 0 0.299 0.861 1.000 160 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(3), SHMT1(2) 4971666 6 5 6 1 2 2 2 0 0 0 0.240 0.873 1.000 161 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(3), JAK2(5), JAK3(5), MAPK1(4), MAPK3(2), STAT3(3), TYK2(10) 14000308 32 22 32 4 12 2 3 8 6 1 0.0325 0.875 1.000 162 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(3), IL13RA2(1), IL4R(9), JAK1(3), JAK2(5), TYK2(10) 12457734 31 24 31 5 11 1 3 10 6 0 0.0655 0.876 1.000 163 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(3), IL13RA2(1), IL4R(9), JAK1(3), JAK2(5), TYK2(10) 12457734 31 24 31 5 11 1 3 10 6 0 0.0655 0.876 1.000 164 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(3), IFNB1(2), JAK1(3), STAT1(4), STAT2(2), TYK2(10) 12879901 26 19 26 4 7 2 2 10 4 1 0.0896 0.877 1.000 165 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(5), PARK2(2), SNCA(1), SNCAIP(1), UBE2G2(1), UBE2L6(1) 7637986 11 11 11 3 7 1 0 2 1 0 0.294 0.879 1.000 166 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(3), ACVR1C(3), AKT1(2), ARRB1(2), ARRB2(1), ATF2(2), ATF4(1), BDNF(1), BRAF(12), CACNA1A(4), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1F(7), CACNA1G(7), CACNA1H(11), CACNA1I(9), CACNA1S(14), CACNA2D1(13), CACNA2D2(3), CACNA2D3(4), CACNA2D4(3), CACNB2(4), CACNB3(4), CACNB4(2), CACNG1(2), CACNG2(2), CACNG3(8), CACNG5(1), CACNG7(3), CACNG8(1), CD14(1), CDC25B(1), CHUK(1), CRKL(2), DAXX(5), DDIT3(2), DUSP1(1), DUSP10(2), DUSP14(1), DUSP16(3), DUSP4(1), DUSP5(4), DUSP7(1), DUSP9(2), EGF(10), EGFR(138), ELK1(5), ELK4(1), FAS(1), FASLG(1), FGF13(3), FGF14(3), FGF16(1), FGF18(2), FGF22(1), FGF4(1), FGF5(3), FGF6(1), FGF7(2), FGFR1(3), FGFR2(3), FGFR3(5), FGFR4(5), FLNA(18), FLNB(11), FLNC(15), FOS(2), GADD45B(1), GNG12(1), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), KRAS(5), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP2K5(2), MAP3K1(9), MAP3K10(1), MAP3K12(6), MAP3K13(3), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K6(1), MAP3K7(3), MAP3K8(4), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(4), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK7(6), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2), MAPKAPK2(2), MAPKAPK3(2), MAPKAPK5(2), MAX(7), MKNK1(2), MRAS(1), NF1(68), NFATC2(7), NFATC4(5), NFKB1(2), NFKB2(2), NLK(1), NR4A1(3), NRAS(5), NTF3(2), NTRK1(4), PAK1(3), PAK2(2), PDGFA(1), PDGFRA(32), PDGFRB(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PPM1A(1), PPM1B(3), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PTPN5(1), PTPN7(2), PTPRR(6), RAC1(1), RAC2(1), RAF1(2), RAPGEF2(5), RASA1(4), RASA2(3), RASGRF1(7), RASGRF2(6), RASGRP1(2), RASGRP2(3), RASGRP3(2), RASGRP4(3), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA5(2), RPS6KA6(5), RRAS(1), SOS1(7), SOS2(5), SRF(3), STK3(3), STMN1(1), TAOK1(3), TAOK2(5), TAOK3(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TNF(1), TNFRSF1A(1), TP53(408), TRAF2(2), ZAK(2) 340640857 1275 601 926 245 357 227 148 290 226 27 <1.00e-15 0.891 1.000 167 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), ME1(2), PC(4), PDHA1(6), SLC25A1(1), SLC25A11(1) 10999700 18 17 16 4 2 4 0 7 5 0 0.258 0.896 1.000 168 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3) 12027388 26 17 26 4 6 4 4 9 3 0 0.0743 0.897 1.000 169 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(2), GPI(2), HK1(4), PFKL(5), PGK1(3), PKLR(4), TPI1(1) 11011208 23 16 23 3 9 7 0 3 4 0 0.00812 0.904 1.000 170 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(3) 3666216 5 3 5 2 1 1 0 2 1 0 0.649 0.912 1.000 171 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(7), LPO(5), MPO(4), PRDX1(1), TPO(10), TYR(5) 11481609 32 22 32 7 15 7 2 6 1 1 0.0438 0.913 1.000 172 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(12), CDC25A(1), CDC25B(1), CHEK1(6), MYT1(7), WEE1(2), YWHAH(2) 16361101 31 22 31 6 4 2 5 7 13 0 0.376 0.914 1.000 173 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS1(2), ALAS2(1), CPO(3), FECH(2), GATA1(1), HBA2(1), HBB(1), HMBS(1), UROD(1), UROS(1) 9374306 16 12 16 3 4 3 2 6 1 0 0.164 0.919 1.000 174 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(9), AGT(3), AGTR1(1), AGTR2(4), KNG1(4), NOS3(10), REN(7) 11814268 38 33 34 10 19 4 2 6 7 0 0.177 0.922 1.000 175 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(13), DFFA(2), GZMA(1), GZMB(3), HMGB2(1), PRF1(3), SET(1) 12572264 26 18 26 4 9 2 4 5 6 0 0.0687 0.923 1.000 176 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(2), CSNK2A1(3), ELK1(5), FOS(2), IL6(2), IL6R(1), IL6ST(3), JAK1(3), JAK2(5), JAK3(5), MAP2K1(1), MAPK3(2), PTPN11(11), RAF1(2), SHC1(1), SOS1(7), SRF(3), STAT3(3) 28432575 61 47 59 9 11 12 4 23 10 1 0.00672 0.924 1.000 177 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(1), IFNGR2(4), JAK1(3), JAK2(5), STAT1(4) 9717927 19 14 19 4 1 0 4 8 5 1 0.339 0.924 1.000 178 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(2), NR1I3(1), PTGS1(3), PTGS2(3) 6332472 13 12 13 4 5 2 0 3 3 0 0.510 0.935 1.000 179 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(4), GAD1(3), HDC(5), TH(3), TPH1(5) 7173404 20 15 19 6 11 4 0 4 1 0 0.186 0.937 1.000 180 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), NFS1(3), THTPA(2) 7608183 16 9 16 4 3 3 3 5 2 0 0.470 0.937 1.000 181 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(8), GLS(3), GLUD1(4), GOT1(2) 9251054 19 12 19 4 4 1 2 7 5 0 0.425 0.940 1.000 182 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(7), PCYT1A(2), PDHA1(6), PDHA2(7), SLC18A3(1) 8291589 25 20 23 9 7 8 2 3 5 0 0.263 0.946 1.000 183 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(5), CKM(3), EIF4E(2), FBL(2), LDHA(1), LDHB(2), LDHC(1), NCL(3) 10599502 19 13 19 5 5 4 2 4 4 0 0.335 0.958 1.000 184 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(6), DPYS(5), ENPP1(5), ENPP3(2), PANK2(1), PANK4(3) 16531564 25 20 24 5 4 5 0 11 5 0 0.319 0.959 1.000 185 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(2), GOT1(2), GOT2(1), LDHA(1), LDHB(2), LDHC(1) 8119109 9 6 9 1 1 5 0 3 0 0 0.163 0.960 1.000 186 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), OXCT1(1) 4012273 2 2 2 0 0 1 0 1 0 0 0.592 0.961 1.000 187 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1), AASS(1), KARS(2) 5609809 5 5 5 2 2 0 0 2 1 0 0.767 0.963 1.000 188 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(2), CD86(3), HLA-DRA(4), HLA-DRB1(1), IFNG(2), IFNGR1(1), IFNGR2(4), IL12B(4), IL12RB1(4), IL12RB2(4), IL18(3), IL18R1(4), IL4R(9) 15050265 45 37 44 14 15 2 5 16 7 0 0.299 0.964 1.000 189 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF2(2), EPO(2), FLT3(8), IGF1(3), IL1A(1), IL3(2), IL6(2), IL9(1), KITLG(3), TGFB2(2), TGFB3(1) 9796105 28 21 28 9 5 5 5 10 3 0 0.433 0.964 1.000 190 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADM(2), ACADS(5), ECHS1(3), HADHA(3) 6418039 14 11 13 5 4 3 2 2 3 0 0.437 0.964 1.000 191 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), NGFR(1), RAF1(2) 9801701 16 12 15 3 3 4 3 1 4 1 0.104 0.964 1.000 192 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAK1(2), BAX(1), BCL2(3), BCL2L11(1), CASP8AP2(1), CASP9(1), CES1(3) 13027583 15 12 15 2 5 2 1 4 3 0 0.173 0.967 1.000 193 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(1), CES1(3) 7173782 8 8 8 2 6 2 0 0 0 0 0.267 0.967 1.000 194 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(3), DCN(3), FMOD(1), KERA(4), LUM(7) 4302532 18 17 17 7 4 2 3 8 1 0 0.640 0.969 1.000 195 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(2), CYP2A7(1), NAT1(1), NAT2(3), XDH(11) 9455748 22 17 22 6 6 5 1 7 3 0 0.239 0.970 1.000 196 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(9), CD44(6), FCGR3A(1), IL1B(3), IL6R(1), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF8(4), TNFSF8(3) 15663743 35 27 34 8 13 7 3 5 7 0 0.0423 0.971 1.000 197 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(7), GBA(1), LPO(5), MPO(4), TPO(10) 9953096 27 20 27 8 15 7 1 3 1 0 0.150 0.973 1.000 198 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(4), HK2(5), HK3(5), PGM1(1), PGM3(1), TGDS(2) 12133883 20 15 20 3 10 5 2 2 1 0 0.0328 0.976 1.000 199 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(2), FOS(2), MAPK1(4), MAPK8(2), NFE2L2(1), PRKCA(6) 10546092 17 13 17 4 3 3 4 2 4 1 0.178 0.979 1.000 200 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), GLS(3), GLUD1(4), OAT(1), PRODH(1) 6560824 11 8 11 4 3 1 0 5 2 0 0.651 0.979 1.000 201 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(2), DPYD(6), DPYS(5), ENPP1(5), ENPP3(2), ILVBL(5), PANK2(1), PANK4(3), VNN1(2) 20514867 32 25 31 6 6 6 1 13 6 0 0.176 0.980 1.000 202 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(6), FUCA2(4), GLB1(2), HEXA(1), HEXB(1), LCT(13), MAN2C1(2), MANBA(1), NEU1(2), NEU2(8), NEU3(2), NEU4(2) 19665622 45 35 45 10 12 7 8 12 6 0 0.0963 0.980 1.000 203 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(3), ECHS1(3), EHHADH(2), HADHA(3), SDS(1) 5735428 12 9 12 7 3 3 2 1 3 0 0.746 0.981 1.000 204 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(5), GNAS(4), GNB1(1), PRKAR1A(2) 7851446 12 12 12 3 6 1 0 3 2 0 0.432 0.983 1.000 205 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(3), BAK1(2), BAX(1), BCL2(3), BIRC2(3), BIRC3(1), CASP8(2), CASP9(1), CYCS(2), DFFA(2), DIABLO(2) 15941883 22 16 22 5 5 4 3 7 3 0 0.292 0.984 1.000 206 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(9), ACE2(7), AGT(3), AGTR1(1), AGTR2(4), ANPEP(5), CMA1(3), CTSA(1), CTSG(5), ENPEP(10), LNPEP(3), MME(3), NLN(1), REN(7), THOP1(5) 25162003 67 52 62 14 23 10 7 15 12 0 0.0177 0.984 1.000 207 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(1), BDH2(1), HMGCS1(2), HMGCS2(3), OXCT1(1), OXCT2(1) 8521839 10 5 10 1 2 3 0 4 1 0 0.188 0.984 1.000 208 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(2), GRIA2(2), PPP1R1B(1) 4492415 5 4 5 2 3 0 0 2 0 0 0.588 0.986 1.000 209 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(5), ARHGDIB(1), CASP1(8), CASP10(2), CASP8(2), CASP9(1), CYCS(2), GZMB(3), PRF1(3) 15283399 30 24 29 9 6 7 3 12 2 0 0.382 0.987 1.000 210 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(2), ENO3(2), FARS2(3), GOT1(2), GOT2(1), PAH(4), TAT(3), YARS(1) 9843109 20 13 19 4 10 4 1 3 2 0 0.162 0.987 1.000 211 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(2), RAB3A(1), RAB9A(1) 5054138 4 3 4 1 2 1 0 1 0 0 0.573 0.987 1.000 212 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(1), GGT1(3), SHMT1(2) 6582337 6 6 6 2 2 2 2 0 0 0 0.457 0.988 1.000 213 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(5), NRG2(1), PRKCA(6), PSEN1(1) 10694245 13 9 13 2 4 1 2 4 1 1 0.203 0.988 1.000 214 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(2), CHAT(7), DBH(4), DDC(5), GAD1(3), GAD2(1), HDC(5), MAOA(3), PAH(4), SLC18A3(1), TH(3), TPH1(5) 17106931 45 33 44 13 21 9 2 10 3 0 0.0787 0.989 1.000 215 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(1), CDC25B(1), CSK(2), PRKCA(6), PTPRA(7), SRC(2) 10931833 21 14 21 4 9 5 3 3 0 1 0.0768 0.989 1.000 216 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL15(2), IL16(9), IL18(3), IL1A(1), IL3(2), IL5(1), IL6(2), IL9(1), TNF(1) 11770120 31 24 31 10 5 4 5 12 5 0 0.453 0.990 1.000 217 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ANKRD1(1), CYR61(1), DUSP14(1), EIF4E(2), HBEGF(1), IFNG(2), IFRD1(3), IL18(3), IL1A(1), IL1R1(4), NR4A3(1), WDR1(3) 12822925 27 23 27 9 5 4 3 6 9 0 0.641 0.990 1.000 218 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(3), BIRC3(1), CASP10(2), CASP8(2), CASP9(1), DFFA(2), GZMB(3), PRF1(3), SCAP(3), SREBF1(7), SREBF2(4) 21732665 34 27 34 7 11 7 6 8 2 0 0.0772 0.990 1.000 219 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP54(2), SRP68(2), SRP72(3), SRPR(7) 8951311 15 10 15 3 5 1 3 3 3 0 0.313 0.990 1.000 220 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT2(2), FUT3(2), FUT5(6), FUT6(3), ST3GAL3(2) 6053179 16 13 16 6 10 1 0 4 1 0 0.547 0.991 1.000 221 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(4), HK2(5), HK3(5), ISYNA1(2), PGM1(1), PGM3(1), TGDS(2) 13862482 22 16 22 3 10 6 2 3 1 0 0.0171 0.991 1.000 222 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(3), MBTPS1(2), MBTPS2(3), SCAP(3), SREBF1(7), SREBF2(4) 14266597 24 18 24 6 5 5 3 8 3 0 0.233 0.992 1.000 223 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PCYT1A(2), PCYT1B(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), WBSCR22(3) 16725887 31 19 31 7 8 4 5 8 6 0 0.147 0.992 1.000 224 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), GCK(2), GFPT1(5), GNPDA1(3), HEXA(1), HEXB(1), HK1(4), HK2(5), HK3(5), PGM3(1), RENBP(4), UAP1(2) 20112258 35 26 35 5 12 7 5 7 4 0 0.0175 0.992 1.000 225 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), ATP6V0C(1), CAT(3), EPX(7), LPO(5), MPO(4), PRDX1(1), SHMT1(2), TPO(10) 14045390 34 20 34 9 16 9 2 4 2 1 0.0622 0.993 1.000 226 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(5), FHL5(3), FSHR(3), GNAS(4), XPO1(1) 11387888 16 15 16 4 5 3 3 3 2 0 0.390 0.993 1.000 227 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(5), CTH(2), GGT1(3), MARS(7), MARS2(2), MAT1A(2), SCLY(3), SEPHS1(1) 14692219 25 16 25 4 5 8 3 6 3 0 0.0481 0.993 1.000 228 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(3), EPX(7), LPO(5), MPO(4), MTHFR(7), SHMT1(2), TPO(10) 13795631 39 22 39 9 17 9 4 6 3 0 0.0384 0.993 1.000 229 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(2), F2(4), F2R(2), F5(13), F7(2), FGA(12), FGB(4), FGG(6), PROS1(3), SERPINC1(2) 19445524 50 45 49 14 15 7 10 13 5 0 0.150 0.993 1.000 230 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADM(2), ACADS(5), ACADVL(3), ACSL1(4), ACSL3(3), ACSL4(6), CPT1A(2), CPT2(2), EHHADH(2), HADHA(3), PECR(2), SCP2(1), SLC25A20(1) 19965837 37 25 36 9 6 8 4 8 11 0 0.136 0.994 1.000 231 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(15), MAP2(9), PPP1CA(1), PPP2CA(4), PRKACG(1), PRKAG1(1), PRKAR2B(1), PRKCE(1) 21589195 33 19 33 4 5 5 4 10 9 0 0.0785 0.994 1.000 232 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(6), APOBEC2(1), APOBEC3B(2), APOBEC3C(1), APOBEC3F(5), APOBEC3G(1), APOBEC4(1) 8694663 21 20 21 7 8 4 2 6 1 0 0.445 0.994 1.000 233 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(4), PRKCA(6), TGM2(1) 5890694 13 10 13 5 5 0 1 6 0 1 0.585 0.995 1.000 234 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), WBSCR22(3) 17834744 32 18 31 8 10 4 6 7 5 0 0.157 0.995 1.000 235 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(17), CPT1A(2), LEPR(3), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(2) 17181944 30 18 30 4 10 3 1 9 7 0 0.0540 0.995 1.000 236 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL10(1) 4722277 10 8 9 5 4 1 1 3 1 0 0.686 0.996 1.000 237 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(2), ATG5(4), ATG7(3), IFNA10(2), IFNA21(5), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNG(2), PIK3C3(2), PIK3R4(3), PRKAA1(3), PRKAA2(2), ULK1(2), ULK2(7) 25054644 41 23 40 5 7 4 10 11 9 0 0.00725 0.996 1.000 238 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(4), FDFT1(1), FDPS(3), HMGCS1(2), IDI1(2), LSS(1), MVD(4), MVK(1), NSDHL(2), SQLE(1) 15693512 23 15 23 6 8 1 5 6 3 0 0.344 0.996 1.000 239 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(4), FDFT1(1), FDPS(3), IDI1(2), LSS(1), MVD(4), MVK(1), NQO1(2), NQO2(1), SQLE(1) 13172587 20 13 20 5 6 1 5 4 4 0 0.343 0.996 1.000 240 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(2), EPO(2), EPOR(1), GRIN1(3), JAK2(5), NFKB1(2), NFKBIA(3), RELA(1), SOD2(1) 15051554 21 15 21 5 6 2 2 8 3 0 0.290 0.997 1.000 241 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CCNH(2), CDC25A(1), CDC25B(1), CDK7(1), SHH(3), XPO1(1) 10326589 11 8 11 3 5 5 1 0 0 0 0.281 0.997 1.000 242 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(1), JAK1(3), JAK2(5), JAK3(5), PIAS3(3), PTPRU(3), REG1A(2), SRC(2), STAT3(3) 18144077 30 25 30 7 7 4 2 10 7 0 0.201 0.997 1.000 243 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(1), RAC1(1), WASF1(1), WASL(2) 9651747 12 6 12 3 0 2 1 6 3 0 0.525 0.997 1.000 244 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), LCT(13), MPI(1), PGM1(1), PYGL(6), PYGM(2), TPI1(1), TREH(2) 15928923 30 20 30 7 8 6 5 5 6 0 0.0761 0.997 1.000 245 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP6(2), ACPP(4), ACPT(2), ALPI(2), ALPP(7), ALPPL2(6), CYP3A4(5), CYP3A43(1), CYP3A7(6), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), PON1(4), PON3(1) 21370075 46 41 43 12 24 3 5 8 6 0 0.0918 0.998 1.000 246 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(3), MST1(8), MST1R(4), TNF(1) 7789225 17 12 16 6 5 6 1 3 2 0 0.426 0.998 1.000 247 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ATP6AP1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), CCL5(1), CHUK(1), CSK(2), CXCL1(1), EGFR(138), F11R(2), GIT1(2), HBEGF(1), IKBKB(2), JAM2(4), JAM3(2), LYN(2), MAPK10(1), MAPK12(2), MAPK13(2), MAPK8(2), MAPK9(2), MET(13), NFKB1(2), NFKB2(2), NFKBIA(3), NOD1(3), PAK1(3), PLCG1(12), PLCG2(12), PTPN11(11), PTPRZ1(15), RAC1(1), RELA(1), SRC(2), TCIRG1(2), TJP1(8) 83441568 289 191 209 51 52 85 26 89 36 1 1.49e-08 0.998 1.000 248 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(4), F2R(2), F2RL3(3), GNAI1(4), GNB1(1), ITGA1(4), ITGB1(3), MAP2K1(1), MAPK1(4), MAPK3(2), PLA2G4A(7), PLCB1(4), PRKCA(6), PTGS1(3), PTK2(2), RAF1(2), SRC(2), TBXAS1(2) 28959295 56 44 56 11 13 4 11 20 6 2 0.0460 0.998 1.000 249 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3D(1), CD3E(2), CD3G(1), IFNG(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TGFBR3(3), TOB1(1), TOB2(1) 12550187 25 18 24 6 6 7 4 5 3 0 0.119 0.999 1.000 250 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(7), CYP11B2(3), HSD11B1(2), HSD3B1(2), HSD3B2(1) 8188994 17 17 17 7 9 3 1 1 3 0 0.450 0.999 1.000 251 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(2), JAK1(3), PTPRU(3), REG1A(2), STAT1(4), STAT2(2), TYK2(10) 14845481 28 21 28 8 8 1 2 9 7 1 0.342 0.999 1.000 252 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB8(3) 10360020 16 9 16 3 4 5 3 3 1 0 0.184 0.999 1.000 253 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(9), BST1(1), CD38(1), ENPP1(5), ENPP3(2), NADK(1), NADSYN1(5), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(1), NNT(6), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(3), NT5M(1), NUDT12(1) 25558214 49 34 47 13 11 15 7 11 5 0 0.0926 0.999 1.000 254 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6) 9496019 20 14 20 7 10 3 2 3 2 0 0.359 0.999 1.000 255 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6) 9496019 20 14 20 7 10 3 2 3 2 0 0.359 0.999 1.000 256 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(1), CASP8(2), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2) 9991431 16 15 16 6 5 3 2 3 3 0 0.557 0.999 1.000 257 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), CALM3(1), CALML3(1), CALML6(1), CDS2(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(2), INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPP5B(4), INPP5D(5), INPP5E(1), INPPL1(8), ITGB1BP3(1), ITPK1(3), ITPR1(9), ITPR2(15), ITPR3(18), OCRL(7), PI4KA(8), PI4KB(4), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3C3(2), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(5), PRKCA(6), PRKCG(4), PTEN(115), PTPMT1(1), SYNJ1(6), SYNJ2(12) 148310621 541 338 463 87 112 99 76 109 142 3 5.24e-13 0.999 1.000 258 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), CYCS(2), GPD2(1), SDHA(4), SDHC(2), UQCRC1(4) 7844250 14 10 13 5 2 3 5 4 0 0 0.498 0.999 1.000 259 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CDO1(1), CTH(2), GOT1(2), GOT2(1), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), SDS(1), SULT1B1(9), SULT1C2(3) 14877425 26 18 26 7 3 8 2 10 3 0 0.350 0.999 1.000 260 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(1), JAK1(3), JAK2(5), PTPRU(3), REG1A(2), STAT1(4) 13576306 21 15 21 7 3 1 2 7 7 1 0.502 0.999 1.000 261 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), ARHGDIB(1), BIRC2(3), BIRC3(1), CASP1(8), CASP10(2), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CYCS(2), DFFA(2), GZMB(3), LMNA(2), LMNB2(3), PRF1(3) 22953722 38 27 38 9 9 9 6 11 3 0 0.143 0.999 1.000 262 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(6), ACO2(4), AFMID(1), HAO1(4), HAO2(2), HYI(3), MTHFD1(3), MTHFD1L(1) 15880457 24 16 24 5 4 5 4 6 5 0 0.195 0.999 1.000 263 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(3), ECHS1(3), HADHA(3), HSD17B4(3), MECR(2), PPT2(1) 10070357 15 12 15 6 2 3 2 4 4 0 0.675 0.999 1.000 264 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), ST6GALNAC4(1), ST8SIA1(2) 6701819 10 10 10 5 4 0 1 3 2 0 0.839 0.999 1.000 265 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), FUT2(2), GCNT2(2), ST8SIA1(2) 7299839 7 5 7 6 3 1 0 1 2 0 0.980 0.999 1.000 266 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(2), CP(7), EPRS(5), FECH(2), GUSB(3), HCCS(5), HMBS(1), HMOX1(1), PPOX(2), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(3), UGT2B4(9), UROD(1), UROS(1) 32493976 67 52 66 15 18 9 13 23 4 0 0.0372 0.999 1.000 267 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(3), AASDHPPT(1), AASS(1), KARS(2) 8268664 8 7 8 4 2 0 1 3 2 0 0.880 0.999 1.000 268 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), MIOX(1), UGDH(1) 10137379 20 12 20 5 11 2 2 3 2 0 0.184 0.999 1.000 269 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CD8A(1), CSF2(2), EPO(2), IL3(2), IL5(1), IL6(2), IL7(1), IL9(1) 7211957 14 12 14 7 4 2 1 5 2 0 0.776 0.999 1.000 270 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), SULT1A2(1), SULT2A1(2), SUOX(2) 7241287 6 3 6 5 0 1 0 4 1 0 0.970 0.999 1.000 271 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2) 6687477 16 10 16 8 3 1 1 11 0 0 0.854 0.999 1.000 272 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(6), ACO2(4), HAO1(4), HAO2(2), HYI(3), MTHFD1(3), MTHFD1L(1) 15162449 23 15 23 5 4 5 4 6 4 0 0.199 0.999 1.000 273 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), CHPF(1), CHST11(3), CHST13(3), CHST3(3), CHSY1(4), DSE(6), UST(1), XYLT1(3), XYLT2(3) 16680196 28 23 28 6 10 4 2 8 4 0 0.0818 0.999 1.000 274 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(1), CYP11A1(7), CYP11B1(3), CYP11B2(3), CYP21A2(2), HSD11B1(2), HSD3B1(2), HSD3B2(1) 11007722 23 22 23 8 9 3 2 4 5 0 0.452 0.999 1.000 275 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(1), CYP11A1(7), CYP11B1(3), CYP11B2(3), CYP21A2(2), HSD11B1(2), HSD3B1(2), HSD3B2(1) 11007722 23 22 23 8 9 3 2 4 5 0 0.452 0.999 1.000 276 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(13), EP300(6), ESR1(3), MAPK1(4), MAPK3(2), PELP1(2), SRC(2) 17522973 32 21 31 7 10 5 4 7 5 1 0.118 0.999 1.000 277 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(17), ACACB(18), FASN(3), MCAT(4), OXSM(3) 18824614 45 35 45 13 15 8 5 10 7 0 0.165 0.999 1.000 278 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(4), RECK(4), TIMP1(1), TIMP3(2), TIMP4(2) 8936183 13 10 13 5 5 2 1 3 2 0 0.575 0.999 1.000 279 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ACYP1(1), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), SDS(1) 9252577 12 10 12 9 2 4 1 2 3 0 0.926 1.000 1.000 280 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(6), FOS(2), IL3(2), IL3RA(4), JAK2(5), MAP2K1(1), MAPK3(2), PTPN6(1), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2) 20999106 36 27 35 9 10 3 5 11 6 1 0.221 1.000 1.000 281 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), AGPS(3), ENPP2(8), ENPP6(2), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLD1(8), PPAP2A(2), PPAP2C(1) 27531374 57 39 56 14 17 8 8 19 5 0 0.0984 1.000 1.000 282 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(4), NDUFA4(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), NDUFV2(1) 8275691 12 7 12 5 0 1 2 5 4 0 0.818 1.000 1.000 283 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(3), ECHS1(3), EHHADH(2), HADHA(3), HSD17B4(3), SIRT1(1), SIRT2(1), SIRT5(3), SIRT7(1), VNN2(1) 14062823 21 17 21 9 5 3 2 5 6 0 0.715 1.000 1.000 284 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(4), GNB1(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6) 11433929 18 15 18 5 8 0 1 7 1 1 0.577 1.000 1.000 285 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(2), B3GALT2(1), B3GALT5(2), B3GNT5(4), FUT2(2), FUT3(2), ST3GAL3(2), ST3GAL4(3) 8560651 19 14 19 7 10 0 1 6 2 0 0.564 1.000 1.000 286 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(4), COL4A2(7), COL4A3(1), COL4A4(11), COL4A5(11), COL4A6(9), F10(2), F12(1), F2(4), F2R(2), F5(13), F8(24), F9(7), FGA(12), FGB(4), FGG(6), KLKB1(7), PROS1(3), SERPINC1(2), SERPING1(4) 52878189 134 100 131 31 32 28 21 33 19 1 0.00237 1.000 1.000 287 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), NFKBIA(3), PLCB1(4), PRKCA(6), RELA(1) 9782185 16 13 16 8 5 0 1 7 2 1 0.855 1.000 1.000 288 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(2), PTK2B(5), SHC1(1), SOS1(7), SRC(2) 10484569 17 15 17 5 3 3 1 6 4 0 0.411 1.000 1.000 289 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(5), ADRB2(1), GNAS(4), PLCE1(10), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RAP2B(4) 17565426 29 24 29 7 13 6 2 4 4 0 0.163 1.000 1.000 290 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(5), ADRB2(1), CFTR(6), GNAS(4), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), SLC9A3R1(1) 15569044 22 20 22 5 11 3 1 5 2 0 0.224 1.000 1.000 291 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(3), ADRB2(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), DRD1(1), DRD2(1), DRD3(3), DRD5(10), HRH1(3), HRH2(3), HTR1A(2), HTR1B(2), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4) 30495966 83 64 81 20 46 13 6 12 6 0 0.000409 1.000 1.000 292 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM3(1), CDKN1A(2), MARCKS(1), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKCA(6), SP1(1), SP3(5), SYT1(2) 24908800 51 38 49 13 13 8 7 14 8 1 0.100 1.000 1.000 293 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(3), RPE(1), UGDH(1), UGP2(1), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(9), UGT2A3(12), UGT2B10(7), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), XYLB(1) 32395525 89 70 87 25 23 10 17 33 6 0 0.148 1.000 1.000 294 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(3), BMPR1A(1), BMPR1B(1), BMPR2(1) 7460567 6 5 6 6 2 0 2 1 1 0 0.991 1.000 1.000 295 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(5), HSD17B3(1), HSD17B4(3), HSD17B7(2), HSD3B1(2), HSD3B2(1) 9608865 14 14 13 8 2 5 3 2 2 0 0.787 1.000 1.000 296 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(1), PSMC3(2), PSMD1(1), PSMD11(2), PSMD2(3) 18984499 22 12 22 4 3 9 3 4 3 0 0.129 1.000 1.000 297 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ARG2(2), ASL(2), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), GAMT(1), GATM(2), GLUD1(4), NAGS(1), OAT(1), ODC1(3), OTC(2), SMS(2) 20822996 39 27 39 9 10 6 4 11 8 0 0.184 1.000 1.000 298 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(3), FARSA(1), GOT1(2), GOT2(1), PAH(4), TAT(3), YARS(1), YARS2(1) 10343210 16 13 15 5 6 5 1 3 1 0 0.431 1.000 1.000 299 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(2), CMAS(2), CYB5R1(1), GFPT1(5), GFPT2(3), GNPDA1(3), GNPNAT1(2), HEXA(1), HEXB(1), HK1(4), HK2(5), HK3(5), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), NANS(1), NPL(1), PGM3(1), RENBP(4), UAP1(2) 34057697 56 42 56 12 16 10 10 12 8 0 0.0545 1.000 1.000 300 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(7), AGT(3), AGTR1(1), AGTR2(4), CMA1(3), COL4A1(4), COL4A2(7), COL4A3(1), COL4A4(11), COL4A5(11), COL4A6(9), REN(7) 30054633 68 49 64 22 19 19 8 12 9 1 0.203 1.000 1.000 301 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(12), CREB1(2), CREB3(3), DUSP4(1), DUSP9(2), EEF2K(2), EIF4E(2), MAP2K1(1), MAP2K2(1), MAP3K8(4), MAPK1(4), MAPK3(2), MKNK1(2), NFKB1(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), SHC1(1), SOS1(7), SOS2(5), TRAF3(1) 35132114 69 45 63 17 16 6 8 25 13 1 0.192 1.000 1.000 302 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 17885914 24 20 24 7 7 7 4 5 0 1 0.242 1.000 1.000 303 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 17885914 24 20 24 7 7 7 4 5 0 1 0.242 1.000 1.000 304 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 17885914 24 20 24 7 7 7 4 5 0 1 0.242 1.000 1.000 305 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(8), EPHB1(4), FYN(2), ITGA1(4), ITGB1(3), L1CAM(12), LYN(2), SELP(4) 18735937 39 27 39 12 13 7 8 10 1 0 0.257 1.000 1.000 306 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(4), DLD(3), FH(1), IDH2(20), IDH3A(1), IDH3B(1), OGDH(1), PC(4), PDHA1(6), PDHA2(7), PDHB(1), PDK1(2), PDK3(3), PDK4(2), PDP2(3), SDHA(4), SDHC(2), SUCLA2(1), SUCLG1(2), SUCLG2(1) 33713637 69 55 49 19 10 24 9 19 7 0 0.0713 1.000 1.000 307 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), BLNK(2), BTK(3), CARD11(8), CD19(2), CD22(10), CD72(3), CD79A(1), CD81(2), CHUK(1), CR2(8), FOS(2), GSK3B(1), IFITM1(2), IKBKB(2), INPP5D(5), KRAS(5), LILRB3(9), LYN(2), MALT1(4), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), NRAS(5), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG2(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PTPN6(1), RAC1(1), RAC2(1), RASGRP3(2), VAV1(9), VAV2(4), VAV3(3) 88389197 317 218 262 70 71 63 41 65 76 1 7.57e-05 1.000 1.000 308 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(2), FOS(2), MAPK3(2), OPRK1(2), POLR2A(9), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1) 15314843 22 19 22 7 7 2 2 7 3 1 0.457 1.000 1.000 309 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(17), ACACB(18), ACADM(2), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ALDH7A1(2), ECHS1(3), EHHADH(2), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), MLYCD(4), MUT(2), PCCA(3), PCCB(4), SUCLA2(1), SUCLG1(2), SUCLG2(1) 47091000 101 65 101 21 33 23 8 24 13 0 0.00410 1.000 1.000 310 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(13), EP300(6), LPL(2), NCOA1(3), NCOA2(5), PPARG(3), RXRA(4) 21938268 36 27 35 10 9 7 2 11 7 0 0.307 1.000 1.000 311 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(15), ABCB11(3), ABCB4(12), ABCC1(6), ABCC3(6) 17031636 42 31 41 14 11 7 4 12 7 1 0.348 1.000 1.000 312 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(3), GLS2(1), GLUD1(4), GLUD2(4) 5397172 12 11 12 6 3 2 0 6 1 0 0.857 1.000 1.000 313 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(3), ELK1(5), EPO(2), EPOR(1), FOS(2), JAK2(5), MAP2K1(1), MAPK3(2), MAPK8(2), PLCG1(12), PTPN6(1), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2) 25561941 49 38 47 12 9 9 7 15 8 1 0.106 1.000 1.000 314 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(2), CASP8(2), CFLAR(1), DAXX(5), DFFA(2), FAF1(4), LMNA(2), LMNB2(3), MAP3K1(9), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(14), PTPN13(4), RB1(30), RIPK2(1), SPTAN1(8) 48587747 98 73 92 14 13 19 12 16 36 2 0.000813 1.000 1.000 315 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(3), BCL2(3), CASP9(1), CYCS(2), DAXX(5), FAS(1), FASLG(1), IL1A(1), MAPKAPK2(2), MAPKAPK3(2), TNF(1) 13468717 22 14 22 8 1 6 4 8 3 0 0.665 1.000 1.000 316 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), DAG1(3) 7238664 5 5 5 3 1 1 3 0 0 0 0.779 1.000 1.000 317 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(2), GZMB(3), HMGB2(1), TOP2A(4), TOP2B(3) 10729155 13 8 13 5 5 1 2 3 2 0 0.696 1.000 1.000 318 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(9), BAIAP2(3), CASP1(8), CASP8(2), GAPDH(1), INSR(6), ITCH(1), MAGI1(6), MAGI2(6), RERE(11), WWP1(3), WWP2(2) 28480069 58 40 57 14 16 15 5 15 7 0 0.104 1.000 1.000 319 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CAMK4(3), CAMKK1(2), CAMKK2(2), CREB1(2), SYT1(2) 13760218 23 14 23 8 6 5 5 1 6 0 0.384 1.000 1.000 320 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(2), CRADD(2), DFFA(2), LMNA(2), LMNB2(3), MADD(3), MAP3K1(9), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(14), RB1(30), RIPK1(4), SPTAN1(8), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2) 46202376 97 78 91 18 17 17 11 14 36 2 0.00727 1.000 1.000 321 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(3), HS3ST3A1(3), XYLT1(3), XYLT2(3) 7840481 12 12 12 5 6 2 3 1 0 0 0.521 1.000 1.000 322 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(3), HS3ST3A1(3), XYLT1(3), XYLT2(3) 7840481 12 12 12 5 6 2 3 1 0 0 0.521 1.000 1.000 323 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(6), ACTN1(3), ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), ARHGEF6(7), ARHGEF7(2), BCAR1(3), BRAF(12), CDKN2A(6), CSE1L(1), DOCK1(3), EPHB2(5), FYN(2), GRB7(8), ILK(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGA7(4), ITGA8(6), ITGA9(2), MAP3K11(1), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2), MRAS(1), MYLK(7), MYLK2(1), P4HB(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PIK3CA(83), PIK3CB(7), PKLR(4), PLCG1(12), PLCG2(12), PTEN(115), PTK2(2), RAF1(2), RALA(2), ROCK1(4), ROCK2(5), SHC1(1), SOS1(7), SOS2(5), SRC(2), TERF2IP(1), TLN1(5), TLN2(8), VASP(1), WAS(3), ZYX(2) 145289820 448 293 376 72 79 85 70 108 106 0 8.39e-12 1.000 1.000 324 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(3), CRY1(3), CSNK1E(1), PER1(6) 10144550 13 9 12 6 3 3 1 4 2 0 0.826 1.000 1.000 325 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(1), HDAC9(3), MEF2A(4), MEF2B(1), MEF2D(1), MYOD1(1), YWHAH(2) 9249506 15 11 15 6 2 5 2 2 4 0 0.628 1.000 1.000 326 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(5), GALNT10(1), GALNT2(3), GALNT3(1), GALNT4(1), GALNT6(4), GALNT7(1), GALNT8(1), GALNT9(4), GCNT1(2), ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), WBSCR17(11) 17122631 41 31 41 12 16 7 5 8 5 0 0.247 1.000 1.000 327 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3D(1), CD3E(2), CD3G(1), CD4(2), CREBBP(13), CSK(2), GNAS(4), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTPRC(9), ZAP70(8) 27349378 59 45 59 13 21 9 4 17 8 0 0.0727 1.000 1.000 328 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3D(1), CD3E(2), CD3G(1), CD4(2), CREBBP(13), CSK(2), GNAS(4), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTPRC(9), ZAP70(8) 27349378 59 45 59 13 21 9 4 17 8 0 0.0727 1.000 1.000 329 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(4), PDHA1(6), PDHA2(7), PDHB(1) 11898855 23 18 21 9 3 8 2 5 5 0 0.626 1.000 1.000 330 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(4), CAPN1(2), CAPNS1(2), CAPNS2(1), CSNK1A1(2), CSNK1D(2), GSK3B(1), PPP2CA(4) 11056196 18 10 18 7 4 3 4 6 1 0 0.621 1.000 1.000 331 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(1), CBS(5), CTH(2), GGT1(3), LCMT1(3), LCMT2(2), MARS(7), MARS2(2), MAT1A(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SCLY(3), SEPHS1(1), WBSCR22(3) 29619040 52 31 52 10 11 12 8 13 8 0 0.0198 1.000 1.000 332 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), FDXR(1), SHMT1(2) 19029470 25 20 25 7 8 7 4 5 0 1 0.210 1.000 1.000 333 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(5), FOS(2), FYN(2), THBS1(6) 8769079 15 12 15 7 5 5 3 1 1 0 0.529 1.000 1.000 334 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(2), F12(1), F13B(5), F2(4), F5(13), F7(2), F8(24), F9(7), FGA(12), FGB(4), FGG(6), LPA(11), PLAT(3), PLAU(1), PLG(6), SERPINB2(3), SERPINE1(4), SERPINF2(1), VWF(14) 41901114 123 85 121 30 34 22 15 32 20 0 0.00727 1.000 1.000 335 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(3), HPSE(5), HPSE2(5), HYAL1(3), HYAL2(1), IDS(2), LCT(13), NAGLU(3), SPAM1(7) 24383102 49 35 47 13 22 5 6 10 6 0 0.145 1.000 1.000 336 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2) 15756123 35 20 35 13 13 2 3 15 2 0 0.531 1.000 1.000 337 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(3), ACTN2(6), ACTN3(1), BCAR1(3), CSK(2), CTNNA1(2), CTNNA2(5), CTNNB1(3), PTK2(2), PXN(1), SRC(2), VCL(1) 22782479 31 21 31 7 11 6 3 7 4 0 0.159 1.000 1.000 338 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), IFNG(2), IL12B(4), IL12RB1(4), IL12RB2(4), JAK2(5), STAT4(4), TYK2(10) 17509149 41 26 41 10 19 2 6 9 5 0 0.140 1.000 1.000 339 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(3), CHST13(3), SULT1A1(1), SULT1A2(1), SULT2A1(2), SULT2B1(3), SUOX(2) 10919578 16 12 16 6 3 2 0 9 2 0 0.691 1.000 1.000 340 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3D(1), CD3E(2), CD3G(1), ETV5(3), IFNG(2), IL12B(4), IL12RB1(4), IL12RB2(4), IL18(3), IL18R1(4), JAK2(5), MAPK8(2), STAT4(4), TYK2(10) 22197772 50 34 50 15 19 3 10 13 5 0 0.278 1.000 1.000 341 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX15(2), ALOX5(2), CYP1A2(4), CYP2C18(3), CYP2C19(6), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP3A4(5), CYP3A43(1), CYP3A7(6), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3) 28335289 61 52 61 16 21 8 7 16 9 0 0.126 1.000 1.000 342 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(1), ESR1(3), GREB1(7), MTA1(1), MTA3(3), PDZK1(1), TUBA8(2) 13013752 19 12 19 8 8 3 1 4 3 0 0.537 1.000 1.000 343 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), CASP8(2), CCL3(1), CCL5(1), CD14(1), CD40(1), CD86(3), CHUK(1), CXCL9(1), FOS(2), IFNA10(2), IFNA21(5), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IKBKB(2), IKBKE(5), IL12B(4), IL1B(3), IL6(2), IRAK1(3), IRAK4(2), IRF3(3), IRF5(2), IRF7(3), LBP(5), LY96(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K7(3), MAP3K8(4), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK9(2), NFKB1(2), NFKB2(2), NFKBIA(3), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), RAC1(1), RELA(1), RIPK1(4), SPP1(2), STAT1(4), TBK1(2), TICAM1(1), TLR1(6), TLR2(5), TLR3(6), TLR4(2), TLR5(4), TLR6(8), TLR7(10), TLR8(1), TLR9(5), TNF(1), TOLLIP(1), TRAF3(1) 106599471 342 234 288 75 69 67 56 69 78 3 2.13e-05 1.000 1.000 344 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(5), CCNB1(2), GNAI1(4), GNAS(4), GNB1(1), MAPK1(4), MAPK3(2), MYT1(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RPS6KA1(5), SRC(2) 24422777 41 36 41 10 12 3 5 8 12 1 0.245 1.000 1.000 345 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP4B(2), ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), ATP7A(12), ATP7B(4), COX10(5), COX6B1(1), COX7A1(1), COX7B(3), COX7C(1), NDUFA10(4), NDUFA4(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(1), SDHA(4), SHMT1(2), UQCRC1(4), UQCRH(2) 45362924 83 58 81 15 16 15 15 27 9 1 0.00279 1.000 1.000 346 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(1), PON1(4), PON3(1) 10665323 14 10 13 9 6 0 1 5 2 0 0.961 1.000 1.000 347 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPPL1(8), MIOX(1), OCRL(7), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3CA(83), PIK3CB(7), PIK3CG(12), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCG1(12), PLCG2(12) 53283675 191 150 154 42 38 39 35 45 34 0 0.00168 1.000 1.000 348 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM1(1), CALM3(1), CRKL(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), PAK1(3), PLCG1(12), PRKCA(6), PTK2B(5), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SRC(2), SYT1(2) 33878160 73 55 68 16 18 16 12 11 14 2 0.0107 1.000 1.000 349 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(17), ACAT2(1), ACYP1(1), ADH5(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), DLD(3), HAGH(1), LDHA(1), LDHB(2), LDHC(1), LDHD(1), ME1(2), ME2(2), ME3(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PKLR(4) 43921933 82 62 80 21 28 20 5 18 11 0 0.0365 1.000 1.000 350 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(2), BCR(3), BLNK(2), ELK1(5), FOS(2), LYN(2), MAP2K1(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8IP3(6), PAPPA(6), RAC1(1), RPS6KA1(5), RPS6KA3(4), SHC1(1), SOS1(7), VAV1(9), VAV2(4), VAV3(3) 38113630 78 54 76 19 18 16 8 22 13 1 0.0428 1.000 1.000 351 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(9), PRKACG(1), PRKAG1(1), PRKAR2B(1) 11980933 12 8 12 5 2 0 1 7 1 1 0.828 1.000 1.000 352 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(3), DLG4(6), EPHB2(5), F2(4), F2RL1(4), F2RL3(3), MAP2K5(2), MAPK1(4), MAPK7(6), MAPK8(2), MYEF2(3), PLD1(8), PLD3(1), PTK2(2), RAF1(2), RASAL1(5), SRC(2), TEC(4), VAV1(9) 32644368 75 53 74 20 24 12 9 21 9 0 0.0755 1.000 1.000 353 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(5), GNAS(4), GNB1(1), PPP2CA(4), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1) 18254383 27 18 27 6 11 2 0 11 3 0 0.297 1.000 1.000 354 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(4), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), DDC(5), EPX(7), GOT1(2), GOT2(1), HPD(1), LPO(5), MAOA(3), MAOB(2), MPO(4), PRDX1(1), TAT(3), TPO(10) 26119457 63 45 62 18 33 10 5 11 3 1 0.0428 1.000 1.000 355 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2AK4(4), EIF2S2(2), EIF2S3(2), GSK3B(1), PPP1CA(1) 13718454 13 11 13 9 1 2 4 4 2 0 0.958 1.000 1.000 356 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(3), AR(4), ESR1(3), ESR2(6), ESRRA(2), HNF4A(7), NPM1(3), NR0B1(1), NR1D1(1), NR1D2(1), NR1H2(4), NR1H3(5), NR1I2(2), NR1I3(1), NR2C2(3), NR2E1(2), NR2F1(1), NR2F2(5), NR3C1(3), NR4A1(3), NR4A2(1), NR5A1(1), NR5A2(2), PGR(9), PPARA(4), PPARG(3), RARB(3), ROR1(3), RORA(1), RORC(4), RXRA(4), RXRB(1), RXRG(3), THRA(5), THRB(2), VDR(2) 50022598 108 75 105 27 41 15 15 26 11 0 0.0234 1.000 1.000 357 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(12), BMPR1B(1), CCND2(2), CDK4(1), CDKN1B(4), CEBPB(2), DMC1(2), EGR1(5), ESR2(6), FSHR(3), GJA4(1), LHCGR(2), MLH1(4), MSH5(2), NCOR1(9), NR5A1(1), NRIP1(4), PGR(9), PRLR(2), SMPD1(1), VDR(2), ZP2(6) 41666246 81 55 80 20 14 17 10 24 15 1 0.170 1.000 1.000 358 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(2), CREB1(2), DAXX(5), DDIT3(2), ELK1(5), HMGN1(1), MAP3K1(9), MAP3K5(4), MAP3K7(3), MAP3K9(6), MAPKAPK2(2), MAPKAPK5(2), MAX(7), MEF2A(4), MEF2B(1), MEF2D(1), MKNK1(2), PLA2G4A(7), RAC1(1), RIPK1(4), RPS6KA5(2), SHC1(1), STAT1(4), TGFB2(2), TGFB3(1), TGFBR1(4), TRADD(1), TRAF2(2) 43561753 87 63 83 18 21 19 14 20 12 1 0.0106 1.000 1.000 359 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(2), RPN1(1), RPN2(1), UBE3A(1) 15318200 18 11 18 6 4 5 4 2 3 0 0.534 1.000 1.000 360 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(3), RPE(1), UCHL3(1), UGDH(1), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(3), UGT2B4(9) 20876975 41 33 40 13 12 7 6 13 3 0 0.267 1.000 1.000 361 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(3), ASNS(4), CA1(1), CA12(3), CA14(1), CA2(1), CA5A(1), CA6(1), CA9(1), CPS1(8), CTH(2), GLS(3), GLS2(1), GLUD1(4), GLUL(2), HAL(3) 22558785 39 31 39 11 13 7 3 10 6 0 0.262 1.000 1.000 362 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(3), AXIN1(4), BTRC(2), CCND1(4), CREBBP(13), CSNK1A1(2), CSNK1D(2), CSNK2A1(3), CTBP1(5), CTNNB1(3), DVL1(1), FZD1(3), GSK3B(1), MAP3K7(3), NLK(1), PPP2CA(4), WIF1(3), WNT1(1) 34931567 58 38 58 13 11 9 8 16 14 0 0.110 1.000 1.000 363 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(1), ADSL(4), AGXT(2), AGXT2(2), ASL(2), ASNS(4), ASPA(1), CAD(8), CRAT(2), DARS(1), GAD1(3), GAD2(1), GOT1(2), GOT2(1), NARS(1), PC(4) 30931428 43 27 43 8 8 11 4 12 8 0 0.0454 1.000 1.000 364 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), G6PC(8), GAPDH(1), GAPDHS(2), GCK(2), GOT1(2), GOT2(1), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHAL6B(2), LDHB(2), LDHC(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PFKL(5), PFKP(1), PGAM2(1), PGK1(3), PGK2(1), PKLR(4), TNFAIP1(3), TPI1(1) 50402078 98 71 96 23 38 25 4 20 11 0 0.00211 1.000 1.000 365 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2A1(1), AP2M1(1), BIN1(2), CALM1(1), CALM3(1), DNM1(1), EPN1(1), EPS15(3), PICALM(3), PPP3CA(1), PPP3CB(2), PPP3CC(1), SYNJ1(6), SYNJ2(12), SYT1(2) 25660797 42 27 42 13 15 5 7 7 8 0 0.240 1.000 1.000 366 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), BCL2(3), CASP8(2), CYCS(2), MAP2K1(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), NFKB1(2), NSMAF(3), RAF1(2), RELA(1), RIPK1(4), SMPD1(1), TNFRSF1A(1), TRADD(1), TRAF2(2) 24399423 43 34 41 13 11 10 7 5 9 1 0.211 1.000 1.000 367 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), GALNT1(5), GALNT10(1), GALNT11(3), GALNT12(3), GALNT13(4), GALNT14(7), GALNT2(3), GALNT3(1), GALNT4(1), GALNT5(5), GALNT6(4), GALNT7(1), GALNT8(1), GALNT9(4), GALNTL1(1), GALNTL4(1), GALNTL5(1), GCNT1(2), GCNT3(2), GCNT4(3), OGT(9), ST3GAL1(3), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(11) 38364099 80 58 79 21 29 15 6 19 11 0 0.0914 1.000 1.000 368 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(3), B4GALT2(1), G6PC(8), G6PC2(1), GAA(6), GALE(2), GALK1(1), GALK2(1), GALT(1), GANC(5), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(5), HK3(5), HSD3B7(1), LCT(13), MGAM(15), PFKL(5), PFKP(1), PGM1(1), PGM3(1), UGP2(1) 45924164 87 58 87 21 44 12 7 17 7 0 0.00814 1.000 1.000 369 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(5), CALM1(1), CALM3(1), CREB1(2), ELK1(5), FOS(2), GNAI1(4), GNAS(4), GNB1(1), MAP2K1(1), MAPK3(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), RAF1(2), RPS6KA3(4), SYT1(2) 41577812 79 62 77 21 22 9 10 21 15 2 0.0973 1.000 1.000 370 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSS(2), NFKB1(2), NOX1(1), RELA(1), TNF(1), XDH(11) 11807172 19 12 19 9 5 5 0 8 1 0 0.721 1.000 1.000 371 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(2), ALDH5A1(2), CAD(8), CPS1(8), EPRS(5), GAD1(3), GAD2(1), GCLC(1), GFPT1(5), GLS(3), GLS2(1), GLUD1(4), GLUL(2), GOT1(2), GOT2(1), GSS(2), NADSYN1(5), PPAT(2), QARS(5) 39363159 63 43 63 10 13 11 13 18 8 0 0.00722 1.000 1.000 372 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(3) 19677792 13 6 12 3 5 4 1 2 1 0 0.287 1.000 1.000 373 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(7), COL4A3(1), COL4A4(11), COL4A5(11), COL4A6(9), P4HB(1), SLC23A1(2), SLC23A2(3), SLC2A1(4), SLC2A3(5) 29859075 58 43 58 20 19 14 8 10 6 1 0.150 1.000 1.000 374 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA1(1), ACAA2(3), ACADM(2), ACADS(5), ACAT2(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ALDH7A1(2), AOX1(9), BCAT1(1), BCKDHA(1), BCKDHB(2), DBT(3), DLD(3), ECHS1(3), EHHADH(2), HADHA(3), HIBADH(1), HIBCH(2), HMGCS1(2), HMGCS2(3), HSD17B4(3), MCCC1(4), MCCC2(5), MUT(2), OXCT1(1), OXCT2(1), PCCA(3), PCCB(4) 51066936 94 60 90 22 32 22 10 16 14 0 0.0135 1.000 1.000 375 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(4), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), AOC2(1), ASPA(1), CNDP1(4), DDC(5), HAL(3), HARS(4), HDC(5), HNMT(1), MAOA(3), MAOB(2), PRPS1(1), PRPS2(5) 29032709 62 44 62 17 33 8 5 14 2 0 0.0585 1.000 1.000 376 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL4R(9), IRS1(8), JAK1(3), JAK3(5), RPS6KB1(2), SHC1(1), STAT6(5) 17620687 35 30 35 11 9 5 2 11 8 0 0.434 1.000 1.000 377 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(17), ACADL(1), ACADM(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ECHS1(3), EHHADH(2), HADHA(3), LDHA(1), LDHB(2), LDHC(1), MLYCD(4), MUT(2), PCCA(3), PCCB(4), SDS(1), SUCLA2(1), SUCLG1(2), SUCLG2(1) 39288675 77 48 77 21 23 20 6 17 11 0 0.0981 1.000 1.000 378 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3) 16093301 22 17 22 8 6 3 3 7 3 0 0.618 1.000 1.000 379 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(4), ACY3(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDH7A1(2), AMDHD1(2), AOC2(1), ASPA(1), CARM1(1), CNDP1(4), DDC(5), FTCD(4), HAL(3), HARS(4), HARS2(1), HDC(5), HNMT(1), LCMT1(3), LCMT2(2), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), PRPS1(1), PRPS2(5), UROC1(2), WBSCR22(3) 47096984 97 64 97 26 44 12 10 23 8 0 0.0253 1.000 1.000 380 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), IL5(1), MAF(3), MAP2K3(6), NFATC1(2), NFATC2(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1) 14507874 27 19 27 11 12 1 3 8 3 0 0.422 1.000 1.000 381 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT2(1), FBP2(2), G6PC(8), GAA(6), GALE(2), GALK1(1), GALK2(1), GALT(1), GANAB(5), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(5), HK3(5), LCT(13), MGAM(15), PFKP(1), PGM1(1), PGM3(1) 38698990 78 54 78 21 40 12 7 13 6 0 0.0263 1.000 1.000 382 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(4), ACADM(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AOC2(1), CNDP1(4), DPYD(6), DPYS(5), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), HIBCH(2), MLYCD(4), SMS(2), SRM(2) 32059072 63 37 62 17 23 11 4 16 9 0 0.0750 1.000 1.000 383 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CAMK4(3), ESRRA(2), HDAC5(1), MEF2A(4), MEF2B(1), MEF2D(1), PPARA(4), PPP3CA(1), PPP3CB(2), PPP3CC(1), SLC2A4(1), SYT1(2), YWHAH(2) 24081629 37 21 37 12 8 9 6 6 8 0 0.305 1.000 1.000 384 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(3), PIGA(3), PIGB(1), PIGC(1), PIGF(1), PIGG(1), PIGN(2), PIGO(5), PIGQ(3), PIGS(2), PIGT(1), PIGU(2), PIGW(2), PIGX(1), PIGZ(2) 28358561 32 15 32 8 11 3 6 7 5 0 0.199 1.000 1.000 385 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(3), CDH1(4), CREBBP(13), EP300(6), MAP2K1(1), MAP3K7(3), MAPK3(2), SKIL(3), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5) 30471747 47 28 47 11 10 9 7 13 7 1 0.153 1.000 1.000 386 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(2), NFKB1(2), RELA(1), TNFRSF13B(1), TNFRSF17(1), TNFSF13B(1), TRAF2(2), TRAF3(1), TRAF5(3) 17285578 15 10 15 9 6 4 2 1 2 0 0.845 1.000 1.000 387 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(4), ABAT(1), ACADS(5), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH5A1(2), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), L2HGDH(1), OXCT1(1), PDHA1(6), PDHA2(7), PDHB(1), SDS(1) 30627195 62 46 59 21 21 13 5 11 12 0 0.164 1.000 1.000 388 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(7), ARRB2(1), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CLCA1(5), CLCA2(5), CLCA4(2), CNGA3(4), CNGA4(4), CNGB1(5), GNAL(1), GUCA1A(1), GUCA1C(1), PDC(2), PDE1C(9), PRKACG(1), PRKG1(2), PRKG2(6), PRKX(1) 36222503 73 51 73 22 32 12 7 13 9 0 0.0992 1.000 1.000 389 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(4), CALM1(1), CALM3(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), F2(4), FYN(2), GNA11(1), GNAI1(4), GNB1(1), JAK2(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MAPK8(2), MYLK(7), PLCG1(12), PRKCA(6), PTK2B(5), RAF1(2), SHC1(1), SOS1(7), STAT1(4), STAT3(3), STAT5A(1), SYT1(2) 49530850 93 64 91 25 22 11 19 24 14 3 0.0526 1.000 1.000 390 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(3), CALM1(1), CALM3(1), CD79A(1), ELK1(5), FOS(2), LYN(2), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKCA(6), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SYT1(2), VAV1(9) 45429368 91 62 87 26 22 18 12 23 14 2 0.0728 1.000 1.000 391 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), CARD11(8), CBL(2), CBLB(3), CBLC(2), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD40LG(2), CD8A(1), CDK4(1), CHUK(1), CSF2(2), CTLA4(1), FOS(2), FYN(2), GRAP2(2), ICOS(1), IFNG(2), IKBKB(2), IL10(1), IL5(1), ITK(1), KRAS(5), LAT(2), LCK(1), LCP2(1), MALT1(4), MAP3K8(4), NCK1(2), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), NRAS(5), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PDCD1(1), PDK1(2), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKCQ(4), PTPN6(1), PTPRC(9), RASGRP1(2), SOS1(7), SOS2(5), TEC(4), TNF(1), VAV1(9), VAV2(4), VAV3(3), ZAP70(8) 120599490 367 243 308 77 72 68 59 82 84 2 2.50e-05 1.000 1.000 392 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM3(1), CHUK(1), EGR2(2), EGR3(2), MAP3K1(9), NFATC1(2), NFATC2(7), NFKB1(2), NFKBIA(3), PLCG1(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RELA(1), SYT1(2), VIP(2), VIPR2(2) 33245490 58 46 54 18 13 10 6 20 9 0 0.251 1.000 1.000 393 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(17), ACACB(18), ACAT2(1), ACOT12(1), ACSS1(1), ACSS2(4), ACYP1(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), DLD(3), HAGH(1), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), LDHD(1), ME1(2), ME2(2), ME3(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PKLR(4) 55547755 106 81 104 28 39 22 7 25 13 0 0.0277 1.000 1.000 394 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(5), F2(4), F2R(2), FGA(12), FGB(4), FGG(6), PLAT(3), PLAU(1), PLG(6), SERPINB2(3), SERPINE1(4) 15900021 51 43 50 19 15 9 7 14 6 0 0.482 1.000 1.000 395 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), DARS(1), EPRS(5), FARS2(3), GARS(3), HARS(4), IARS(4), KARS(2), LARS(4), MARS(7), MARS2(2), NARS(1), QARS(5), RARS(3), SARS(1), TARS(1), WARS(1), WARS2(2), YARS(1) 38024325 54 36 54 12 8 14 6 18 8 0 0.161 1.000 1.000 396 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPL13(1), MRPS7(3), RPL10L(3), RPL11(2), RPL13A(2), RPL18A(1), RPL22L1(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL37A(1), RPL3L(1), RPL6(1), RPL7(3), RPS11(1), RPS12(2), RPS18(2), RPS2(1), RPS21(1), RPS24(1), RPS3(3), RPS5(1), RPSA(2) 26894393 39 26 38 9 12 1 6 10 10 0 0.468 1.000 1.000 397 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ADC(4), ALDH4A1(2), ALDH5A1(2), CAD(8), CPS1(8), EARS2(1), EPRS(5), GAD1(3), GAD2(1), GCLC(1), GFPT1(5), GFPT2(3), GLS(3), GLS2(1), GLUD1(4), GLUD2(4), GLUL(2), GNPNAT1(2), GOT1(2), GOT2(1), GSS(2), NADSYN1(5), PPAT(2), QARS(5) 46864475 77 52 77 18 15 13 15 23 11 0 0.0681 1.000 1.000 398 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(3), ILVBL(5), LARS(4), PDHA1(6), PDHA2(7), PDHB(1), VARS(4), VARS2(3) 22075375 38 26 36 11 6 10 4 12 6 0 0.329 1.000 1.000 399 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(5), DDX20(1), E2F1(1), E2F4(1), ETS1(5), ETV3(1), FOS(2), HDAC2(7), HDAC5(1), NCOR2(9), RBL1(6), RBL2(3), SIN3A(5), SIN3B(1) 30957249 48 30 47 15 11 8 5 12 12 0 0.438 1.000 1.000 400 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF2(2), HLA-DRA(4), HLA-DRB1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL15(2), IL1A(1), IL3(2), IL5(1), IL6(2), IL7(1), PDGFA(1), TGFB2(2), TGFB3(1), TNF(1) 15750234 32 25 32 12 8 5 6 9 4 0 0.483 1.000 1.000 401 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), GLI2(5), GLI3(6), GSK3B(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), SHH(3), SMO(3), SUFU(4) 19834608 30 22 30 11 10 6 3 7 4 0 0.502 1.000 1.000 402 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(3), ACTN2(6), ACTN3(1), CAPN1(2), CAPNS1(2), CAPNS2(1), ITGA1(4), ITGB1(3), ITGB3(4), PTK2(2), PXN(1), RAC1(1), SPTAN1(8), SRC(2), TLN1(5) 33881972 45 28 45 8 15 4 8 14 4 0 0.0396 1.000 1.000 403 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(3), APC(3), ATF2(2), AXIN1(4), BMP10(2), BMP2(1), BMP4(3), BMP5(8), BMPR1A(1), BMPR2(1), CHRD(2), CTNNB1(3), DVL1(1), FZD1(3), GATA4(3), GSK3B(1), MAP3K7(3), MYL2(2), NPPA(2), RFC1(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TGFBR3(3), WNT1(1) 43278799 66 46 66 12 19 11 9 13 14 0 0.0134 1.000 1.000 404 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(6), FUCA2(4), GLB1(2), HEXA(1), HEXB(1), LCT(13), MAN2B1(7), MAN2B2(7), MAN2C1(2), MANBA(1), NEU1(2), NEU2(8), NEU3(2), NEU4(2) 24244965 59 46 59 20 18 7 8 18 8 0 0.380 1.000 1.000 405 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(4), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), DDC(5), EPX(7), ESCO1(2), ESCO2(2), GOT1(2), GOT2(1), HPD(1), LPO(5), MAOA(3), MAOB(2), MPO(4), PNPLA3(1), SH3GLB1(3), TAT(3), TPO(10) 40655346 70 47 69 19 34 14 5 13 4 0 0.0379 1.000 1.000 406 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM3(1), DLG4(6), GRIN1(3), GRIN2A(17), GRIN2B(9), GRIN2C(6), GRIN2D(5), NOS1(10), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), SYT1(2) 30363151 75 64 75 27 38 7 9 15 5 1 0.236 1.000 1.000 407 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(2), CCR3(2), CFL1(1), GNAS(4), GNB1(1), LIMK1(4), MAP2K1(1), MAPK1(4), MAPK3(2), MYL2(2), NOX1(1), PIK3C2G(10), PLCB1(4), PPP1R12B(1), PRKCA(6), PTK2(2), RAF1(2), ROCK2(5) 29930335 54 44 54 15 13 5 12 14 8 2 0.270 1.000 1.000 408 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(3), ATIC(1), ATP6V0C(1), DHFR(1), GART(4), MTHFD1(3), MTHFD1L(1), MTHFR(7), MTHFS(2), MTR(2), SHMT1(2) 21244740 30 13 30 11 7 7 7 3 5 1 0.372 1.000 1.000 409 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(4), AADAC(1), ABAT(1), ACADS(5), ACAT2(1), ACSM1(6), AKR1B10(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH5A1(2), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), HMGCS1(2), HMGCS2(3), HSD17B4(3), HSD3B7(1), ILVBL(5), L2HGDH(1), OXCT1(1), OXCT2(1), PDHA1(6), PDHA2(7), PDHB(1), PLA1A(4), PPME1(1) 48179369 91 61 88 28 28 14 9 25 15 0 0.136 1.000 1.000 410 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(1), ABAT(1), ACY3(1), ADSL(4), ADSSL1(1), AGXT(2), AGXT2(2), ASL(2), ASNS(4), ASPA(1), ASS1(4), CAD(8), CRAT(2), DARS(1), DARS2(2), DLD(3), GAD1(3), GAD2(1), GOT1(2), GOT2(1), NARS(1), NARS2(1), PC(4), PDHA1(6), PDHA2(7), PDHB(1) 44935938 70 49 67 18 18 18 6 15 13 0 0.0800 1.000 1.000 411 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(5), CD2(1), CD33(6), CD5(2), CD7(3), CSF2(2), IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL3(2), IL5(1), ITGAX(8), TLR2(5), TLR4(2), TLR7(10), TLR9(5) 22060400 61 51 60 23 22 5 7 20 7 0 0.531 1.000 1.000 412 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(4), CAMK2D(1), CAMK2G(2), DAG1(3), ITPR1(9), ITPR2(15), ITPR3(18), NFAT5(3), PDE6A(4), PDE6B(5), PDE6C(7), SLC6A13(4), TF(2) 42628421 77 52 77 24 29 16 12 12 7 1 0.0648 1.000 1.000 413 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(3), ARSE(6), ASAH1(2), B4GALT6(2), DEGS1(2), DEGS2(2), ENPP7(4), GAL3ST1(2), GALC(1), GBA(1), GLA(2), GLB1(2), LCT(13), NEU1(2), NEU2(8), NEU3(2), NEU4(2), PPAP2A(2), PPAP2C(1), SGMS2(3), SGPP1(1), SGPP2(3), SMPD1(1), SMPD2(1), SMPD3(2), SMPD4(1), SPTLC1(2), SPTLC2(2), UGCG(2), UGT8(2) 42537274 80 52 80 25 28 11 13 22 5 1 0.152 1.000 1.000 414 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(1), NCK1(2), NCKAP1(5), NTRK1(4), RAC1(1), WASF1(1), WASF2(1), WASF3(4), WASL(2) 18128904 28 17 28 10 3 4 4 8 9 0 0.584 1.000 1.000 415 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(11), CALM1(1), CALM3(1), CAPNS1(2), CAPNS2(1), EP300(6), HDAC2(7), MEF2D(1), NFATC1(2), NFATC2(7), PPP3CA(1), PPP3CB(2), PPP3CC(1), PRKCA(6), SYT1(2) 28934777 51 35 51 18 14 7 8 12 9 1 0.437 1.000 1.000 416 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(2), MAP2K1(1), MAPK1(4), MAPK3(2), NFKB1(2), NFKBIA(3), PLCB1(4), PRKCA(6), RAF1(2), RELA(1), TNF(1) 18426233 28 23 28 11 6 3 4 8 5 2 0.536 1.000 1.000 417 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(1), ALOX15(2), ALOX5(2), CBR1(2), CBR3(1), CYP4F2(3), CYP4F3(6), EPX(7), GGT1(3), LPO(5), LTA4H(4), MPO(4), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PRDX1(1), PTGES2(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(2), TPO(10) 33130213 80 60 80 25 32 15 6 16 10 1 0.0877 1.000 1.000 418 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACPP(4), ACPT(2), ALPI(2), ALPP(7), ALPPL2(6), CYP19A1(2), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(6), CYP2C18(3), CYP2C19(6), CYP2C8(4), CYP2C9(3), CYP2D6(2), CYP2E1(2), CYP2F1(1), CYP3A4(5), CYP3A7(6), CYP4B1(5), CYP4F8(3), CYP51A1(2), PON1(4) 34718056 83 74 81 26 41 6 9 15 12 0 0.176 1.000 1.000 419 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(4), ADC(4), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AMD1(2), AOC2(1), ARG2(2), ASL(2), ASS1(4), CPS1(8), GATM(2), MAOA(3), MAOB(2), NAGS(1), ODC1(3), OTC(2), SMS(2), SRM(2) 35038014 62 45 61 20 23 7 7 16 9 0 0.353 1.000 1.000 420 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(3), ASAH1(2), CREB1(2), CREB3(3), DAG1(3), EPHB2(5), FOS(2), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(2) 33996203 42 34 42 13 10 7 11 6 8 0 0.286 1.000 1.000 421 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CYP2C19(6), CYP2C9(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(3), EHHADH(2), ESCO1(2), ESCO2(2), HADHA(3), PNPLA3(1), SH3GLB1(3), YOD1(1) 36702728 52 33 51 16 23 10 5 7 7 0 0.168 1.000 1.000 422 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), ANKRD6(4), APC(3), AXIN1(4), AXIN2(2), CSNK1A1(2), CTNNB1(3), DACT1(4), DKK1(2), DKK2(5), DKK4(2), DVL1(1), FSTL1(1), GSK3B(1), LRP1(29), MVP(3), NKD1(2), NKD2(4), PSEN1(1), PTPRA(7), SENP2(3), SFRP1(1), WIF1(3) 47989360 89 61 88 26 28 12 10 23 16 0 0.252 1.000 1.000 423 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(6), AMY2B(6), ENPP1(5), ENPP3(2), G6PC(8), GAA(6), GANAB(5), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(5), HK3(5), MGAM(15), PGM1(1), PGM3(1), PYGB(3), PYGL(6), PYGM(2), SI(11), UCHL3(1), UGDH(1), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(3), UGT2B4(9), UXS1(4) 67732493 143 99 142 32 55 25 16 31 16 0 0.00115 1.000 1.000 424 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(6), ABCC2(1), ABCG2(3), BCHE(2), CES1(3), CES2(2), CYP3A4(5), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2) 27104779 45 35 44 17 17 4 9 9 6 0 0.376 1.000 1.000 425 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), CEL(4), DGAT1(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(2), GK(3), GLA(2), GLB1(2), LCT(13), LIPC(1), LIPF(1), LIPG(4), LPL(2), PNLIP(2), PNLIPRP1(4), PPAP2A(2), PPAP2C(1) 57264992 118 75 118 30 44 18 13 31 12 0 0.00944 1.000 1.000 426 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(4), AOC2(1), CES1(3), ESCO1(2), ESCO2(2), LIPA(2), PLA1A(4), PNPLA3(1), PPME1(1), SH3GLB1(3) 30113623 24 15 24 6 9 6 1 6 2 0 0.211 1.000 1.000 427 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSD(3), ARSE(6), ASAH1(2), GAL3ST1(2), GALC(1), GBA(1), GLA(2), GLB1(2), LCT(13), NEU1(2), NEU2(8), NEU3(2), NEU4(2), PPAP2A(2), PPAP2C(1), SMPD1(1), SMPD2(1), SPTLC1(2), SPTLC2(2), UGCG(2) 28824683 58 38 58 21 21 7 9 16 4 1 0.422 1.000 1.000 428 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), FUCA1(6), FUCA2(4), GBA(1), GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(3), HPSE(5), HPSE2(5), HYAL1(3), HYAL2(1), IDS(2), LCT(13), MAN2B1(7), MAN2B2(7), MAN2C1(2), MANBA(1), NAGLU(3), NEU1(2), NEU2(8), NEU3(2), NEU4(2), SPAM1(7) 41041892 92 70 90 29 34 11 11 25 11 0 0.198 1.000 1.000 429 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(1), BRAF(12), CD244(2), CSF2(2), FAS(1), FASLG(1), FCGR3A(1), FCGR3B(1), FYN(2), GZMB(3), HLA-A(1), HLA-C(1), HLA-E(1), HLA-G(2), ICAM1(3), ICAM2(2), IFNA10(2), IFNA21(5), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), ITGAL(2), ITGB2(5), KIR2DL1(6), KIR2DL3(2), KIR2DL4(1), KIR3DL1(1), KIR3DL2(5), KLRC1(3), KLRC2(5), KLRD1(1), KLRK1(1), KRAS(5), LAT(2), LCK(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MICA(4), MICB(2), NCR1(3), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NRAS(5), PAK1(3), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRF1(3), PRKCA(6), PRKCG(4), PTK2B(5), PTPN11(11), PTPN6(1), RAC1(1), RAC2(1), RAF1(2), SH2D1A(3), SH2D1B(3), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), ULBP1(2), ULBP3(4), VAV1(9), VAV2(4), VAV3(3), ZAP70(8) 134897330 439 288 373 107 81 71 71 116 97 3 0.000214 1.000 1.000 430 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(3), ACADL(1), ACADM(2), ACADS(5), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), AOX1(9), BCAT1(1), BCKDHA(1), BCKDHB(2), ECHS1(3), EHHADH(2), HADHA(3), HIBADH(1), MCCC1(4), MCCC2(5), MUT(2), OXCT1(1), PCCA(3), PCCB(4), SDS(1) 42731475 80 52 76 27 27 21 9 13 10 0 0.187 1.000 1.000 431 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AGK(1), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), AKR1A1(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CEL(4), DAK(2), DGAT1(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(2), GK(3), GK2(5), GLA(2), GLB1(2), GPAM(1), LCT(13), LIPA(2), LIPC(1), LIPF(1), LIPG(4), LPL(2), MGLL(1), PNLIP(2), PNLIPRP1(4), PNPLA3(1), PPAP2A(2), PPAP2C(1) 69729701 134 82 133 32 50 17 16 37 14 0 0.00396 1.000 1.000 432 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(4), ACADL(1), ACADM(2), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), AOC2(1), CNDP1(4), DPYD(6), DPYS(5), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), MLYCD(4), SDS(1), SMS(2) 34500000 63 39 62 23 23 12 3 16 9 0 0.347 1.000 1.000 433 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(3), B4GALT2(1), DPAGT1(2), DPM1(3), FUT8(7), MAN1A1(3), MAN1B1(1), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), RPN1(1), RPN2(1), ST6GAL1(2) 23603810 40 27 40 14 10 11 5 5 9 0 0.313 1.000 1.000 434 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(2), CBL(2), CBLB(3), CBLC(2), CCND1(4), CCND2(2), CCND3(1), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(13), CRLF2(3), CSF2(2), CSF2RA(8), CSF2RB(6), CSF3R(3), EP300(6), EPO(2), EPOR(1), GH1(2), GH2(3), GHR(4), IFNA10(2), IFNA21(5), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), IFNK(1), IFNW1(3), IL10(1), IL10RB(1), IL12B(4), IL12RB1(4), IL12RB2(4), IL13RA1(3), IL13RA2(1), IL15(2), IL15RA(1), IL19(1), IL20(1), IL20RA(3), IL21R(3), IL22(2), IL22RA1(1), IL23A(1), IL23R(5), IL26(3), IL28B(1), IL28RA(1), IL2RB(2), IL3(2), IL3RA(4), IL4R(9), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(3), IRF9(8), JAK1(3), JAK2(5), JAK3(5), LEPR(3), LIFR(2), MPL(5), OSM(1), OSMR(5), PIAS1(2), PIAS3(3), PIAS4(3), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIM1(3), PRL(1), PRLR(2), PTPN11(11), PTPN6(1), SOCS1(1), SOCS4(3), SOCS5(2), SOS1(7), SOS2(5), SPRED1(1), SPRED2(3), SPRY1(1), SPRY2(3), SPRY3(3), SPRY4(3), STAM(2), STAM2(2), STAT1(4), STAT2(2), STAT3(3), STAT4(4), STAT5A(1), STAT5B(2), STAT6(5), TPO(10), TYK2(10) 172621737 492 296 438 109 106 79 78 133 94 2 5.71e-06 1.000 1.000 435 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(2), CREBBP(13), EP300(6), NCOA3(4), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RXRA(4) 24573494 35 26 35 13 10 5 2 10 8 0 0.658 1.000 1.000 436 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(13), DUSP1(1), EP300(6), IKBKB(2), IL1B(3), MAP2K3(6), MAP3K7(3), NFKB1(2), NFKBIA(3), NR3C1(3), RELA(1), TGFBR1(4), TGFBR2(5), TLR2(5), TNF(1) 35255518 59 41 59 19 14 13 7 14 11 0 0.289 1.000 1.000 437 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNB1(2), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1RAP(2), IL1RN(2), IL6(2), IRAK1(3), IRAK2(3), IRAK3(9), MAP2K3(6), MAP3K1(9), MAP3K7(3), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), TGFB2(2), TGFB3(1), TNF(1), TOLLIP(1) 35216894 65 49 63 21 16 17 9 13 10 0 0.179 1.000 1.000 438 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AGXT(2), AGXT2(2), AKR1B10(3), ALAS1(2), ALAS2(1), AMT(3), AOC2(1), CBS(5), CHKB(1), CTH(2), DAO(3), DLD(3), DMGDH(4), GAMT(1), GARS(3), GATM(2), GCAT(2), GLDC(3), HSD3B7(1), MAOA(3), MAOB(2), PHGDH(5), PIPOX(2), PISD(2), PSAT1(4), PSPH(2), SARDH(3), SARS(1), SARS2(2), SDS(1), SHMT1(2), TARS(1), TARS2(2) 50787547 80 56 80 23 25 20 5 22 8 0 0.0630 1.000 1.000 439 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(13), EP300(6), HDAC3(1), IKBKB(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1) 26596690 39 26 39 14 11 6 2 11 9 0 0.515 1.000 1.000 440 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BCL2(3), BIRC2(3), BIRC3(1), CASP10(2), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CYCS(2), DFFA(2), GAS2(1), LMNA(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), SPTAN1(8), TNFRSF25(2), TNFSF10(2), TRADD(1), TRAF2(2) 39721073 49 36 49 14 13 7 5 16 8 0 0.299 1.000 1.000 441 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(2), ACTG1(1), ACTN1(3), ACTN2(6), ACTN3(1), ACTN4(2), ACVR1B(3), ACVR1C(3), BAIAP2(3), CDH1(4), CREBBP(13), CSNK2A1(3), CSNK2B(3), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTNND1(1), EGFR(138), EP300(6), ERBB2(3), FARP2(2), FER(1), FGFR1(3), FYN(2), IGF1R(10), INSR(6), IQGAP1(9), LEF1(1), LMO7(8), MAP3K7(3), MAPK1(4), MAPK3(2), MET(13), MLLT4(10), NLK(1), PARD3(3), PTPN1(1), PTPN6(1), PTPRB(9), PTPRF(10), PTPRJ(5), PTPRM(10), PVRL1(3), PVRL2(1), PVRL3(2), PVRL4(4), RAC1(1), RAC2(1), SMAD2(3), SMAD3(3), SMAD4(1), SNAI2(2), SORBS1(3), SRC(2), SSX2IP(1), TCF7L2(5), TGFBR1(4), TGFBR2(5), TJP1(8), VCL(1), WAS(3), WASF1(1), WASF2(1), WASF3(4), WASL(2), YES1(2) 142208196 388 239 313 84 91 92 37 114 53 1 3.35e-07 1.000 1.000 442 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(2), ACTG1(1), ACTN1(3), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(2), ARHGAP5(5), BCAR1(3), BCL2(3), BIRC2(3), BIRC3(1), BRAF(12), CAV3(1), CCND1(4), CCND2(2), CCND3(1), CHAD(1), COL11A1(9), COL11A2(11), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(7), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(9), COL6A3(28), COL6A6(8), COMP(1), CRKL(2), CTNNB1(3), DIAPH1(5), DOCK1(3), EGF(10), EGFR(138), ELK1(5), ERBB2(3), FARP2(2), FIGF(2), FLNA(18), FLNB(11), FLNC(15), FLT1(10), FN1(9), FYN(2), GSK3B(1), HGF(4), IBSP(1), IGF1(3), IGF1R(10), ILK(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGA7(4), ITGA8(6), ITGA9(2), ITGAV(3), ITGB1(3), ITGB3(4), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), KDR(14), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(7), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), MAP2K1(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(2), MET(13), MYL2(2), MYL5(1), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PARVA(1), PARVB(2), PARVG(1), PDGFA(1), PDGFC(2), PDGFD(4), PDGFRA(32), PDGFRB(4), PGF(1), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(6), PRKCG(4), PTEN(115), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), RAPGEF1(4), RELN(25), ROCK1(4), ROCK2(5), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), SPP1(2), SRC(2), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TLN1(5), TLN2(8), TNC(9), TNN(7), TNR(5), TNXB(14), VASP(1), VAV1(9), VAV2(4), VAV3(3), VCL(1), VEGFA(4), VEGFB(3), VEGFC(3), VWF(14), ZYX(2) 441444470 1267 514 1099 308 297 280 155 305 224 6 6.00e-14 1.000 1.000 443 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(3), ACTN1(3), ACTN2(6), ACTN3(1), ACTN4(2), APC(3), APC2(3), ARAF(1), ARHGEF1(1), ARHGEF12(4), ARHGEF4(4), ARHGEF6(7), ARHGEF7(2), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(1), BAIAP2(3), BCAR1(3), BDKRB1(1), BRAF(12), CD14(1), CFL1(1), CFL2(2), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CRKL(2), CSK(2), CYFIP2(4), DIAPH1(5), DIAPH2(5), DIAPH3(4), DOCK1(3), EGF(10), EGFR(138), EZR(4), F2(4), F2R(2), FGD1(1), FGD3(4), FGF13(3), FGF14(3), FGF16(1), FGF18(2), FGF22(1), FGF4(1), FGF5(3), FGF6(1), FGF7(2), FGFR1(3), FGFR2(3), FGFR3(5), FGFR4(5), FN1(9), GIT1(2), GNA13(1), GNG12(1), GSN(2), IQGAP1(9), IQGAP2(6), IQGAP3(4), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGA7(4), ITGA8(6), ITGA9(2), ITGAD(5), ITGAE(7), ITGAL(2), ITGAM(7), ITGAV(3), ITGAX(8), ITGB1(3), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), KRAS(5), LIMK1(4), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MRAS(1), MSN(2), MYH10(8), MYH14(7), MYH9(3), MYL2(2), MYL5(1), MYLK(7), MYLK2(1), NCKAP1(5), NCKAP1L(4), NRAS(5), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PDGFA(1), PDGFRA(32), PDGFRB(4), PFN4(1), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(1), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), RDX(5), ROCK1(4), ROCK2(5), RRAS(1), SCIN(2), SOS1(7), SOS2(5), SSH1(4), SSH2(2), SSH3(2), TIAM1(5), TIAM2(14), VAV1(9), VAV2(4), VAV3(3), VCL(1), WAS(3), WASF1(1), WASF2(1), WASL(2) 328843494 853 434 710 217 185 177 111 233 144 3 2.71e-07 1.000 1.000 444 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY7(3), ADCY8(3), ADCY9(11), ADRA1A(2), ADRA1B(2), ADRB2(1), AGTR1(1), ATP2A1(3), ATP2A2(4), ATP2A3(4), ATP2B2(8), ATP2B3(8), AVPR1A(6), AVPR1B(2), BDKRB1(1), BST1(1), CACNA1A(4), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1F(7), CACNA1G(7), CACNA1H(11), CACNA1I(9), CACNA1S(14), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CAMK4(3), CCKAR(1), CCKBR(3), CD38(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM5(4), CHRNA7(1), CYSLTR1(2), CYSLTR2(2), DRD1(1), EDNRA(1), EDNRB(1), EGFR(138), ERBB2(3), ERBB3(4), ERBB4(5), F2R(2), GNA11(1), GNA14(3), GNA15(1), GNAL(1), GNAS(4), GRIN1(3), GRIN2A(17), GRIN2C(6), GRIN2D(5), GRM1(7), GRM5(6), GRPR(4), HRH1(3), HRH2(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), ITPR1(9), ITPR2(15), ITPR3(18), LHCGR(2), LTB4R2(1), MYLK(7), MYLK2(1), NOS1(10), NOS3(10), NTSR1(4), P2RX1(2), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), PDE1A(3), PDE1B(2), PDE1C(9), PDGFRA(32), PDGFRB(4), PHKA1(5), PHKA2(5), PHKB(1), PHKG1(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(5), PPID(2), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PTAFR(2), PTGER3(2), PTGFR(7), PTK2B(5), RYR1(15), RYR2(58), RYR3(28), SLC25A4(1), SLC25A5(4), SLC25A6(1), SLC8A1(3), SLC8A2(3), SLC8A3(2), TACR2(2), TACR3(7), TBXA2R(1), TNNC1(1), TNNC2(1), TRHR(2), TRPC1(2), VDAC1(2), VDAC2(2), VDAC3(3) 320706875 846 411 761 253 303 170 84 192 94 3 2.98e-07 1.000 1.000 445 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(5), ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2B(2), ADRA2C(3), ADRB2(1), AGTR1(1), AGTR2(4), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), C5AR1(4), CALCR(9), CALCRL(1), CCKAR(1), CCKBR(3), CGA(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CNR1(1), CNR2(3), CRHR2(5), CTSG(5), CYSLTR1(2), CYSLTR2(2), DRD1(1), DRD2(1), DRD3(3), DRD5(10), EDNRA(1), EDNRB(1), F2(4), F2R(2), F2RL1(4), F2RL3(3), FPR1(1), FSHR(3), GABBR1(2), GABBR2(2), GABRA1(13), GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), GABRA6(15), GABRB1(6), GABRB2(10), GABRB3(8), GABRD(5), GABRE(5), GABRG1(7), GABRG2(6), GABRG3(2), GABRP(4), GABRQ(2), GABRR1(3), GABRR2(1), GALR1(2), GH1(2), GH2(3), GHR(4), GHRHR(3), GHSR(2), GIPR(2), GLP1R(2), GLP2R(3), GLRA1(2), GLRA2(2), GLRA3(3), GLRB(4), GNRHR(3), GPR156(2), GPR35(2), GPR50(3), GPR63(1), GPR83(4), GRIA1(8), GRIA2(2), GRIA3(10), GRIA4(5), GRID1(3), GRID2(5), GRIK1(6), GRIK2(4), GRIK3(6), GRIK4(5), GRIK5(3), GRIN1(3), GRIN2A(17), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRIN3A(5), GRIN3B(2), GRM1(7), GRM2(4), GRM3(16), GRM4(6), GRM5(6), GRM6(6), GRM7(5), GRM8(7), GRPR(4), GZMA(1), HCRTR1(1), HCRTR2(3), HRH1(3), HRH2(3), HRH3(3), HRH4(2), HTR1A(2), HTR1B(2), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), LEPR(3), LHCGR(2), LTB4R(1), LTB4R2(1), MC1R(3), MC2R(2), MC3R(6), MC4R(6), MC5R(5), MCHR1(2), MCHR2(3), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(6), NMUR1(4), NMUR2(6), NPBWR1(2), NPBWR2(4), NPFFR2(2), NPY1R(3), NPY2R(2), NPY5R(3), NR3C1(3), NTSR1(4), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), P2RX1(2), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), P2RY1(1), P2RY10(1), P2RY13(1), P2RY2(3), P2RY4(2), P2RY6(2), P2RY8(6), PARD3(3), PPYR1(1), PRL(1), PRLHR(1), PRLR(2), PRSS1(2), PRSS3(2), PTAFR(2), PTGER3(2), PTGER4(2), PTGFR(7), PTH2R(3), RXFP1(5), RXFP2(6), SCTR(1), SSTR2(3), SSTR3(6), SSTR4(12), SSTR5(1), TAAR1(1), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR2(2), TACR3(7), TBXA2R(1), THRA(5), THRB(2), TRHR(2), TRPV1(4), TSHR(5), UTS2R(2), VIPR1(1), VIPR2(2) 263499197 721 366 709 251 309 111 76 163 62 0 0.000465 1.000 1.000 446 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(2), ACTG1(1), CHAD(1), COL11A1(9), COL11A2(11), COL17A1(5), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(7), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(9), COL6A3(28), COL6A6(8), COMP(1), DES(3), DSC1(6), DSC2(5), DSC3(9), DSG1(8), DSG2(7), DSG3(11), DSG4(7), FN1(9), GJA1(5), GJA10(2), GJA3(1), GJA4(1), GJA8(1), GJA9(1), GJB2(1), GJB3(2), GJB4(2), GJB6(2), GJC1(1), GJC3(2), GJD2(3), GJD4(1), IBSP(1), INA(1), ITGA6(5), ITGB4(8), KRT1(4), KRT12(3), KRT13(6), KRT14(2), KRT15(8), KRT16(5), KRT17(1), KRT18(3), KRT19(1), KRT2(3), KRT20(5), KRT23(2), KRT24(3), KRT25(5), KRT27(2), KRT28(6), KRT3(4), KRT31(4), KRT32(1), KRT33A(7), KRT33B(3), KRT34(4), KRT35(4), KRT36(5), KRT37(7), KRT38(1), KRT39(4), KRT4(1), KRT40(3), KRT5(4), KRT6A(2), KRT6B(5), KRT6C(3), KRT7(1), KRT71(4), KRT73(5), KRT74(1), KRT75(6), KRT76(2), KRT77(1), KRT78(2), KRT79(6), KRT8(5), KRT81(4), KRT82(1), KRT83(4), KRT84(5), KRT86(4), KRT9(4), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(7), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), LMNA(2), LMNB2(3), NES(3), PRPH(1), RELN(25), SPP1(2), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNC(9), TNN(7), TNR(5), TNXB(14), VIM(2), VWF(14) 296115263 672 355 663 263 263 144 60 139 64 2 0.129 1.000 1.000 447 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(2), ACTG1(1), ACTN1(3), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(2), AMOTL1(5), ASH1L(5), CASK(2), CDK4(1), CGN(2), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSDA(1), CSNK2A1(3), CSNK2B(3), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTTN(3), EPB41(1), EPB41L1(2), EPB41L2(8), EPB41L3(12), EXOC3(1), EXOC4(3), F11R(2), GNAI1(4), GNAI2(1), GNAI3(2), HCLS1(4), INADL(7), JAM2(4), JAM3(2), KRAS(5), LLGL1(5), LLGL2(3), MAGI1(6), MAGI2(6), MAGI3(6), MLLT4(10), MPDZ(11), MRAS(1), MYH1(18), MYH10(8), MYH11(14), MYH13(19), MYH14(7), MYH15(10), MYH2(25), MYH3(11), MYH4(20), MYH6(7), MYH7(13), MYH7B(12), MYH8(22), MYH9(3), MYL2(2), MYL5(1), NRAS(5), OCLN(3), PARD3(3), PARD6A(1), PARD6B(4), PPM1J(4), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PPP2R3A(5), PPP2R4(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCI(2), PRKCQ(4), PTEN(115), RAB3B(1), RRAS(1), SPTAN1(8), SRC(2), SYMPK(6), TJAP1(3), TJP1(8), TJP2(1), TJP3(8), YES1(2), ZAK(2) 230549523 599 346 564 133 198 87 71 131 110 2 1.94e-08 1.000 1.000 448 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1(3), ACVR1B(3), ACVR2A(2), AMHR2(2), BMP2(1), BMPR1A(1), BMPR1B(1), BMPR2(1), CCL1(1), CCL11(2), CCL13(1), CCL14(1), CCL15(1), CCL16(1), CCL19(1), CCL2(1), CCL20(1), CCL24(2), CCL26(2), CCL27(1), CCL3(1), CCL5(1), CCR1(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CCR9(2), CD40(1), CD40LG(2), CD70(2), CLCF1(1), CNTF(1), CNTFR(2), CRLF2(3), CSF1R(5), CSF2(2), CSF2RA(8), CSF2RB(6), CSF3R(3), CX3CL1(2), CX3CR1(3), CXCL1(1), CXCL13(1), CXCL6(1), CXCL9(1), CXCR4(2), CXCR6(1), EDA(2), EDA2R(1), EDAR(7), EGF(10), EGFR(138), EPO(2), EPOR(1), FAS(1), FASLG(1), FLT1(10), FLT3(8), FLT4(8), GDF5(2), GH1(2), GH2(3), GHR(4), HGF(4), IFNA10(2), IFNA21(5), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), IFNK(1), IFNW1(3), IL10(1), IL10RB(1), IL12B(4), IL12RB1(4), IL12RB2(4), IL13RA1(3), IL15(2), IL15RA(1), IL17B(1), IL17RA(3), IL17RB(2), IL18(3), IL18R1(4), IL18RAP(9), IL19(1), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), IL1RAP(2), IL20(1), IL20RA(3), IL21R(3), IL22(2), IL22RA1(1), IL23A(1), IL23R(5), IL26(3), IL28B(1), IL28RA(1), IL2RB(2), IL3(2), IL3RA(4), IL4R(9), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(3), INHBA(1), INHBB(1), INHBE(3), KDR(14), KIT(9), KITLG(3), LEPR(3), LIFR(2), LTB(1), LTBR(2), MET(13), MPL(5), NGFR(1), OSM(1), OSMR(5), PDGFC(2), PDGFRA(32), PDGFRB(4), PLEKHO2(1), PPBP(2), PRL(1), PRLR(2), RELT(4), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(4), TNFRSF11B(2), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF21(2), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(1), TNFRSF8(4), TNFRSF9(4), TNFSF10(2), TNFSF11(1), TNFSF13B(1), TNFSF14(7), TNFSF15(3), TNFSF18(1), TNFSF8(3), TNFSF9(5), TPO(10), VEGFA(4), VEGFB(3), VEGFC(3), XCL1(3), XCR1(1) 210791918 644 339 560 196 165 150 73 182 74 0 0.000167 1.000 1.000 449 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(17), ACACB(18), AKT1(2), ARAF(1), BRAF(12), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CBL(2), CBLB(3), CBLC(2), CRKL(2), ELK1(5), EXOC7(3), FASN(3), FBP1(3), FBP2(2), FLOT1(2), FLOT2(3), FOXO1(1), G6PC(8), G6PC2(1), GCK(2), GSK3B(1), GYS1(1), GYS2(2), IKBKB(2), INPP5D(5), INSR(6), IRS1(8), IRS2(1), IRS4(7), KRAS(5), LIPE(3), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(2), MKNK1(2), NRAS(5), PCK1(6), PDE3A(5), PDE3B(3), PFKL(5), PFKP(1), PHKA1(5), PHKA2(5), PHKB(1), PHKG1(3), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PKLR(4), PPARGC1A(1), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R3A(13), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(2), PRKAG3(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCI(2), PRKX(1), PTPN1(1), PTPRF(10), PYGB(3), PYGL(6), PYGM(2), RAF1(2), RAPGEF1(4), RHOQ(1), RPS6KB1(2), RPS6KB2(3), SH2B2(2), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS1(1), SOCS4(3), SORBS1(3), SOS1(7), SOS2(5), SREBF1(7), TRIP10(1), TSC1(2), TSC2(6) 190766650 479 299 418 119 109 82 69 123 92 4 0.000153 1.000 1.000 450 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(3), CD36(5), CD44(6), CHAD(1), COL11A1(9), COL11A2(11), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(7), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(9), COL6A3(28), COL6A6(8), DAG1(3), FN1(9), FNDC1(7), FNDC3A(5), FNDC4(1), FNDC5(1), GP5(2), GP6(1), GP9(1), HMMR(1), HSPG2(24), IBSP(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGA7(4), ITGA8(6), ITGA9(2), ITGAV(3), ITGB1(3), ITGB3(4), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(7), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), RELN(25), SDC1(2), SDC2(1), SDC3(1), SDC4(1), SPP1(2), SV2A(2), SV2B(5), SV2C(4), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNC(9), TNN(7), TNR(5), TNXB(14), VWF(14) 266533048 541 288 539 185 183 125 59 110 62 2 0.00670 1.000 1.000 451 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), CSNK1D(2), DRD1(1), DRD2(1), EGF(10), EGFR(138), GJA1(5), GJD2(3), GNA11(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAS(4), GRM1(7), GRM5(6), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HTR2A(2), HTR2B(2), HTR2C(4), ITPR1(9), ITPR2(15), ITPR3(18), KRAS(5), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAPK1(4), MAPK3(2), MAPK7(6), NPR1(2), NPR2(3), NRAS(5), PDGFA(1), PDGFC(2), PDGFD(4), PDGFRA(32), PDGFRB(4), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKG1(2), PRKG2(6), PRKX(1), RAF1(2), SOS1(7), SOS2(5), SRC(2), TJP1(8), TUBA1A(3), TUBA1B(1), TUBA3C(11), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3) 157336362 466 285 383 115 126 116 45 120 56 3 3.74e-07 1.000 1.000 452 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(6), ABLIM1(3), ABLIM2(2), ABLIM3(9), ARHGEF12(4), CFL1(1), CFL2(2), CXCR4(2), DCC(12), DPYSL5(2), EFNA1(1), EFNA3(4), EFNA5(3), EFNB1(3), EFNB2(2), EFNB3(2), EPHA1(4), EPHA2(2), EPHA3(10), EPHA4(8), EPHA5(9), EPHA6(5), EPHA7(8), EPHA8(10), EPHB1(4), EPHB2(5), EPHB3(1), EPHB4(6), EPHB6(10), FES(6), FYN(2), GNAI1(4), GNAI2(1), GNAI3(2), GSK3B(1), ITGB1(3), KRAS(5), L1CAM(12), LIMK1(4), LRRC4C(6), MAPK1(4), MAPK3(2), MET(13), NCK1(2), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NGEF(7), NRAS(5), NRP1(5), NTN1(3), NTN4(5), NTNG1(2), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PLXNA1(11), PLXNA2(9), PLXNA3(7), PLXNB1(6), PLXNB2(3), PLXNB3(9), PLXNC1(3), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PTK2(2), RAC1(1), RAC2(1), RASA1(4), RGS3(11), RHOD(1), RND1(1), ROBO1(7), ROBO2(11), ROBO3(5), ROCK1(4), ROCK2(5), SEMA3A(5), SEMA3C(12), SEMA3D(3), SEMA3E(14), SEMA3F(2), SEMA4A(3), SEMA4B(2), SEMA4C(1), SEMA4D(3), SEMA4F(5), SEMA4G(3), SEMA5B(2), SEMA6A(3), SEMA6B(5), SEMA6C(2), SEMA6D(6), SEMA7A(4), SLIT1(6), SLIT2(8), SLIT3(11), SRGAP1(4), SRGAP2(5), SRGAP3(2), UNC5A(2), UNC5B(1), UNC5C(5), UNC5D(2) 234885834 499 279 490 161 142 79 69 138 70 1 0.0240 1.000 1.000 453 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(3), ACTN2(6), ACTN3(1), ACTN4(2), ARHGAP5(5), BCAR1(3), CDH5(5), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTNND1(1), CXCR4(2), CYBA(1), CYBB(2), ESAM(1), EZR(4), F11R(2), GNAI1(4), GNAI2(1), GNAI3(2), ICAM1(3), ITGA4(8), ITGAL(2), ITGAM(7), ITGB1(3), ITGB2(5), ITK(1), JAM2(4), JAM3(2), MAPK12(2), MAPK13(2), MLLT4(10), MMP9(4), MSN(2), MYL2(2), MYL5(1), NCF1(3), NCF2(5), NCF4(1), NOX1(1), NOX3(5), OCLN(3), PIK3CA(83), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R1(56), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PRKCA(6), PRKCG(4), PTK2(2), PTK2B(5), PTPN11(11), PXN(1), RAC1(1), RAC2(1), RAPGEF3(2), RAPGEF4(3), RASSF5(1), RHOH(1), ROCK1(4), ROCK2(5), SIPA1(3), TXK(2), VASP(1), VAV1(9), VAV2(4), VAV3(3), VCAM1(2), VCL(1) 147824267 424 278 368 127 109 65 64 97 87 2 0.0320 1.000 1.000 454 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ADRA1A(2), ADRA1B(2), ADRB2(1), ANXA6(3), ARRB1(2), ARRB2(1), ATP1A4(2), ATP1B1(1), ATP1B2(1), ATP2A2(4), ATP2A3(4), ATP2B2(8), ATP2B3(8), CACNA1A(4), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1S(14), CACNB3(4), CALM1(1), CALM3(1), CALR(2), CAMK1(2), CAMK2A(4), CAMK2D(1), CAMK2G(2), CAMK4(3), CASQ1(2), CASQ2(3), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), GJA1(5), GJA4(1), GJB2(1), GJB3(2), GJB4(2), GJB6(2), GNA11(1), GNAI2(1), GNAI3(2), GNAO1(4), GNAZ(1), GNB1(1), GNB2(2), GNB3(1), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GNG5(1), GRK4(5), GRK5(4), ITPR1(9), ITPR2(15), ITPR3(18), KCNB1(5), KCNJ3(2), KCNJ5(5), MIB1(5), MYCBP(1), NME7(2), PEA15(1), PKIB(1), PLCB3(4), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCQ(4), PRKD1(1), RGS1(1), RGS11(1), RGS14(1), RGS18(2), RGS19(1), RGS3(11), RGS4(4), RGS6(3), RGS7(3), RGS9(4), RYR1(15), RYR2(58), RYR3(28), SFN(3), SLC8A1(3), SLC8A3(2), USP5(1), YWHAB(2), YWHAH(2), YWHAQ(1) 223287268 475 271 470 159 187 75 61 89 60 3 0.00895 1.000 1.000 455 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ATF4(1), CACNA1C(7), CACNA1D(11), CACNA1F(7), CACNA1S(14), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CGA(1), EGFR(138), ELK1(5), GNA11(1), GNAS(4), GNRHR(3), HBEGF(1), ITPR1(9), ITPR2(15), ITPR3(18), KRAS(5), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAP3K3(2), MAP3K4(7), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK7(6), MAPK8(2), MAPK9(2), NRAS(5), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLD1(8), PRKACG(1), PRKCA(6), PRKCD(3), PRKX(1), PTK2B(5), RAF1(2), SOS1(7), SOS2(5), SRC(2) 151643632 431 262 348 103 128 109 41 107 43 3 3.58e-08 1.000 1.000 456 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(3), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ARRB1(2), ARRB2(1), ATF1(1), ATF2(2), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(4), CACNB3(4), CALCA(2), CALM1(1), CALM3(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CNN2(2), CORIN(5), CREB3(3), DGKZ(2), FOS(2), GABPA(2), GBA2(1), GJA1(5), GNB1(1), GNB2(2), GNB3(1), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GNG5(1), GRK4(5), GRK5(4), GUCY1A3(3), IGFBP2(1), IGFBP6(1), IL1B(3), IL6(2), ITPR1(9), ITPR2(15), ITPR3(18), MIB1(5), MYL2(2), MYLK2(1), NFKB1(2), NOS1(10), NOS3(10), PDE4B(2), PDE4D(8), PKIB(1), PLCB3(4), PLCD1(4), PLCG1(12), PLCG2(12), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCH(4), PRKCQ(4), PRKD1(1), RAMP3(2), RGS1(1), RGS11(1), RGS14(1), RGS18(2), RGS19(1), RGS3(11), RGS4(4), RGS6(3), RGS7(3), RGS9(4), RLN1(1), RYR1(15), RYR2(58), RYR3(28), SFN(3), SLC8A1(3), SP1(1), TNXB(14), USP5(1), YWHAB(2), YWHAH(2), YWHAQ(1) 205983677 435 254 430 148 163 61 56 94 58 3 0.0302 1.000 1.000 457 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(3), ACVR1B(3), ACVRL1(6), AKT1(2), AURKB(1), BMPR1A(1), BMPR2(1), BUB1(5), CDKL1(2), CDKL2(2), CDS2(2), CLK1(2), CLK2(1), CLK4(2), CSNK2A1(3), CSNK2B(3), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(2), INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPPL1(8), MAP3K10(1), NEK1(4), NEK3(4), OCRL(7), PAK4(3), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3CA(83), PIK3CB(7), PIK3CG(12), PIM2(4), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCG1(12), PLCG2(12), PLK3(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCQ(4), PRKD1(1), PRKG1(2), RAF1(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), STK11(1), TGFBR1(4), VRK1(3) 134227032 334 230 296 80 83 63 56 71 58 3 0.000192 1.000 1.000 458 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(3), CADM1(4), CADM3(1), CD2(1), CD22(10), CD226(1), CD274(1), CD276(2), CD28(2), CD34(1), CD4(2), CD40(1), CD40LG(2), CD58(2), CD6(2), CD86(3), CD8A(1), CDH1(4), CDH15(3), CDH2(2), CDH3(3), CDH4(8), CDH5(5), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(3), CNTN2(4), CNTNAP1(5), CNTNAP2(17), CTLA4(1), ESAM(1), F11R(2), GLG1(3), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(5), HLA-DOA(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(3), HLA-G(2), ICAM1(3), ICAM2(2), ICOS(1), ICOSLG(4), ITGA4(8), ITGA6(5), ITGA8(6), ITGA9(2), ITGAL(2), ITGAM(7), ITGAV(3), ITGB1(3), ITGB2(5), ITGB7(7), ITGB8(2), JAM2(4), JAM3(2), L1CAM(12), MAG(5), MPZ(2), MPZL1(2), NCAM1(4), NEGR1(5), NEO1(9), NFASC(2), NLGN1(4), NLGN2(4), NLGN3(5), NRCAM(8), NRXN1(10), NRXN2(1), NRXN3(8), OCLN(3), PDCD1(1), PDCD1LG2(1), PTPRC(9), PTPRF(10), PTPRM(10), PVR(3), PVRL1(3), PVRL2(1), PVRL3(2), SDC1(2), SDC2(1), SDC3(1), SDC4(1), SELE(8), SELP(4), SELPLG(3), SIGLEC1(6), SPN(1), VCAM1(2), VCAN(10) 175606064 378 228 372 149 135 65 37 88 53 0 0.281 1.000 1.000 459 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(3), ACTN2(6), ACTN3(1), ACTN4(2), DES(3), DMD(23), FAM48A(2), MYBPC1(4), MYBPC2(4), MYBPC3(1), MYH3(11), MYH6(7), MYH7(13), MYH8(22), MYL1(2), MYL2(2), MYL3(1), MYOM1(5), NEB(26), TMOD1(1), TNNC2(1), TNNI1(1), TNNT1(4), TNNT2(1), TNNT3(4), TPM1(6), TPM2(1), TPM3(3), TPM4(1), TTN(226), VIM(2) 162329489 389 221 384 107 133 60 40 116 38 2 0.00688 1.000 1.000 460 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(3), ADRB2(1), AGTR1(1), AGTR2(4), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), CCBP2(1), CCKAR(1), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CCR9(2), CHML(4), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(3), CXCR4(2), DRD1(1), DRD2(1), DRD3(3), DRD5(10), EDNRA(1), EDNRB(1), F2R(2), F2RL1(4), F2RL3(3), FPR1(1), FSHR(3), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GPR17(2), GPR173(1), GPR174(2), GPR27(1), GPR35(2), GPR37(5), GPR37L1(1), GPR4(3), GPR50(3), GPR6(3), GPR63(1), GPR77(1), GPR83(4), GPR85(4), GPR87(1), GRPR(4), HCRTR1(1), HCRTR2(3), HRH1(3), HRH2(3), HRH3(3), HTR1A(2), HTR1B(2), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), LHCGR(2), LTB4R(1), MC1R(3), MC3R(6), MC4R(6), MC5R(5), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(6), NMUR1(4), NMUR2(6), NPY1R(3), NPY2R(2), NPY5R(3), NTSR1(4), OPN1SW(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), OR10A5(2), OR11A1(1), OR1C1(4), OR1F1(2), OR1Q1(1), OR2H1(3), OR5V1(3), OR7A5(1), OR7C1(2), P2RY1(1), P2RY10(1), P2RY12(2), P2RY13(1), P2RY2(3), P2RY6(2), PPYR1(1), PTAFR(2), PTGER4(2), PTGFR(7), RGR(1), RRH(1), SSTR2(3), SSTR3(6), SSTR4(12), SUCNR1(3), TBXA2R(1), TRHR(2) 144477208 350 214 345 138 168 51 38 73 20 0 0.0325 1.000 1.000 461 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ADK(1), ADSL(4), ADSSL1(1), AK1(1), AK5(3), AK7(9), ALLC(6), AMPD1(8), AMPD2(4), AMPD3(2), ATIC(1), CANT1(4), DCK(2), ENPP1(5), ENPP3(2), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), FHIT(1), GART(4), GDA(2), GMPR(1), GMPR2(3), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HPRT1(1), IMPDH1(5), IMPDH2(1), NME7(2), NPR1(2), NPR2(3), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(3), NT5M(1), NUDT2(1), PAICS(2), PDE10A(2), PDE11A(6), PDE1A(3), PDE1C(9), PDE2A(5), PDE3B(3), PDE4A(3), PDE4B(2), PDE4C(3), PDE4D(8), PDE5A(1), PDE7A(2), PDE7B(2), PDE8A(7), PDE8B(2), PDE9A(2), PFAS(7), PKLR(4), PNPT1(1), POLA1(3), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1), PPAT(2), PRIM1(2), PRIM2(2), PRPS1(1), PRPS1L1(3), PRPS2(5), RRM1(3), RRM2(1), RRM2B(1), XDH(11) 194199771 333 200 331 108 108 63 35 82 45 0 0.0452 1.000 1.000 462 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(6), AMY2B(6), ASCC3(7), ATP13A2(3), DDX18(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(5), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(4), DHX58(2), ENPP1(5), ENPP3(2), ENTPD7(2), EP400(9), ERCC2(3), ERCC3(2), G6PC(8), G6PC2(1), GAA(6), GANC(5), GBA(1), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(5), HK3(5), IFIH1(3), LYZL1(1), MGAM(15), MOV10L1(7), PGM1(1), PGM3(1), PYGB(3), PYGL(6), PYGM(2), RAD54B(5), RAD54L(6), RUVBL2(4), SETX(5), SI(11), SKIV2L2(3), SMARCA2(5), SMARCA5(3), TREH(2), UGDH(1), UGP2(1), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(9), UGT2A3(12), UGT2B10(7), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), UXS1(4) 147067142 294 187 292 79 96 48 38 79 33 0 0.00550 1.000 1.000 463 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(12), CACNA1A(4), GNA11(1), GNA13(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(4), GNAS(4), GNAZ(1), GRIA1(8), GRIA2(2), GRIA3(10), GRID2(5), GRM1(7), GRM5(6), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IGF1(3), IGF1R(10), ITPR1(9), ITPR2(15), ITPR3(18), KRAS(5), LYN(2), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), NOS1(10), NOS3(10), NPR1(2), NPR2(3), NRAS(5), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PRKCA(6), PRKCG(4), PRKG1(2), PRKG2(6), RAF1(2), RYR1(15) 131179024 276 182 266 90 81 41 43 67 41 3 0.102 1.000 1.000 464 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(7), BDKRB1(1), C1QA(2), C1QB(1), C1QC(1), C1R(2), C1S(5), C2(2), C3(19), C3AR1(3), C4BPA(6), C4BPB(2), C5(7), C5AR1(4), C6(4), C7(5), C8A(4), C8B(7), C9(2), CD46(5), CD55(2), CD59(1), CFB(7), CFD(1), CFH(15), CFI(1), CPB2(1), CR1(5), CR2(8), F10(2), F12(1), F13A1(5), F13B(5), F2(4), F2R(2), F5(13), F7(2), F8(24), F9(7), FGA(12), FGB(4), FGG(6), KLKB1(7), KNG1(4), MASP1(2), MASP2(1), MBL2(4), PLAT(3), PLAU(1), PLG(6), PROS1(3), SERPINA1(2), SERPINA5(2), SERPINC1(2), SERPIND1(1), SERPINE1(4), SERPINF2(1), SERPING1(4), VWF(14) 107553879 278 180 275 82 86 50 33 72 37 0 0.00770 1.000 1.000 465 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ASIP(1), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CREB1(2), CREB3(3), CREB3L1(2), CREB3L2(1), CREB3L3(4), CREB3L4(1), CREBBP(13), CTNNB1(3), DCT(1), DVL1(1), DVL2(3), DVL3(3), EDNRB(1), EP300(6), FZD1(3), FZD10(5), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(4), GNAS(4), GSK3B(1), KIT(9), KITLG(3), KRAS(5), LEF1(1), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MC1R(3), NRAS(5), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), RAF1(2), TCF7L2(5), TYR(5), TYRP1(6), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2(8), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2) 129660716 258 180 251 77 92 30 34 56 44 2 0.0257 1.000 1.000 466 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(5), ADCY8(3), ARAF(1), ATF4(1), BRAF(12), CACNA1C(7), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(4), CAMK2D(1), CAMK2G(2), CAMK4(3), CREBBP(13), EP300(6), GRIA1(8), GRIA2(2), GRIN1(3), GRIN2A(17), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRM1(7), GRM5(6), ITPR1(9), ITPR2(15), ITPR3(18), KRAS(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), NRAS(5), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP3CA(1), PPP3CB(2), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), RAF1(2), RAPGEF3(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA6(5) 118570822 248 166 238 68 85 29 33 68 30 3 0.00503 1.000 1.000 467 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(7), ABCA10(5), ABCA12(5), ABCA13(22), ABCA2(4), ABCA3(5), ABCA4(11), ABCA5(7), ABCA6(9), ABCA7(11), ABCA8(5), ABCA9(6), ABCB1(15), ABCB10(3), ABCB11(3), ABCB4(12), ABCB5(9), ABCB6(1), ABCB7(6), ABCB8(2), ABCB9(4), ABCC1(6), ABCC10(13), ABCC11(8), ABCC12(4), ABCC2(1), ABCC3(6), ABCC4(8), ABCC5(6), ABCC6(2), ABCC8(7), ABCC9(20), ABCD1(3), ABCD2(5), ABCD3(1), ABCG1(3), ABCG2(3), ABCG4(4), ABCG5(4), ABCG8(5), CFTR(6), TAP1(2), TAP2(4) 140615356 273 160 270 101 83 42 39 78 28 3 0.311 1.000 1.000 468 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADK(1), ADSL(4), AK1(1), AK5(3), ALLC(6), AMPD1(8), AMPD2(4), AMPD3(2), ATIC(1), ATP1B1(1), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5I(1), CANT1(4), DCK(2), ENPP1(5), ENPP3(2), ENTPD1(3), FHIT(1), GART(4), GDA(2), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HPRT1(1), IMPDH1(5), IMPDH2(1), NPR1(2), NPR2(3), NT5C(3), NT5E(3), NT5M(1), NUDT2(1), PAICS(2), PDE1A(3), PDE4A(3), PDE4B(2), PDE4C(3), PDE4D(8), PDE5A(1), PDE6B(5), PDE6C(7), PDE7B(2), PDE8A(7), PDE9A(2), PFAS(7), PKLR(4), POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(3), PRPS2(5), RRM1(3), RRM2(1) 152547429 255 157 255 96 87 48 23 63 34 0 0.412 1.000 1.000 469 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), AKAP1(2), AKAP11(3), AKAP12(1), AKAP3(2), AKAP4(8), AKAP5(3), AKAP6(12), AKAP7(2), AKAP8(5), AKAP9(15), ARHGEF1(1), CALM1(1), CALM3(1), GNA11(1), GNA13(1), GNA14(3), GNA15(1), GNAI2(1), GNAI3(2), GNAL(1), GNAO1(4), GNAZ(1), GNB1(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GNG5(1), GNGT2(1), ITPR1(9), KCNJ3(2), KRAS(5), NRAS(5), PALM2(1), PDE1A(3), PDE1B(2), PDE1C(9), PDE4A(3), PDE4B(2), PDE4C(3), PDE4D(8), PDE7A(2), PDE7B(2), PDE8A(7), PDE8B(2), PLCB3(4), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCI(2), PRKCQ(4), PRKD1(1), PRKD3(2), RRAS(1), USP5(1) 139100343 234 155 229 75 69 40 26 54 43 2 0.0928 1.000 1.000 470 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), BCAR1(3), CAPN1(2), CAPN10(4), CAPN11(6), CAPN3(3), CAPN5(2), CAPN6(3), CAPN7(1), CAPN9(4), CAPNS1(2), CAV3(1), CSK(2), DOCK1(3), FYN(2), ILK(1), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGA7(4), ITGA8(6), ITGA9(2), ITGAD(5), ITGAE(7), ITGAL(2), ITGAM(7), ITGAV(3), ITGAX(8), ITGB1(3), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAPK10(1), MAPK12(2), MAPK4(2), MAPK7(6), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PIK3R2(4), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAPGEF1(4), ROCK1(4), ROCK2(5), SDCCAG8(4), SEPP1(2), SHC1(1), SHC3(1), SORBS1(3), SOS1(7), SRC(2), TLN1(5), TNS1(6), VASP(1), VAV2(4), VAV3(3), VCL(1), ZYX(2) 159327918 253 155 252 91 85 39 31 65 33 0 0.237 1.000 1.000 471 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(5), CD14(1), CD19(2), CD1A(3), CD1B(5), CD1D(4), CD1E(6), CD2(1), CD22(10), CD33(6), CD34(1), CD36(5), CD37(1), CD38(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD44(6), CD5(2), CD55(2), CD59(1), CD7(3), CD8A(1), CR1(5), CR2(8), CSF1R(5), CSF2(2), CSF2RA(8), CSF3R(3), DNTT(3), EPO(2), EPOR(1), FCER2(1), FCGR1A(1), FLT3(8), GP5(2), GP9(1), GYPA(1), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), IL3(2), IL3RA(4), IL4R(9), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL7(1), IL7R(3), IL9R(3), ITGA1(4), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(5), ITGAM(7), ITGB3(4), KIT(9), KITLG(3), MME(3), MS4A1(3), TFRC(2), THPO(2), TNF(1), TPO(10) 96874832 241 154 240 78 85 42 27 55 32 0 0.0278 1.000 1.000 472 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG1(1), ALG10B(3), ALG12(2), ALG13(4), ALG14(1), ALG3(4), ALG6(3), B3GNT2(1), B3GNT7(2), B4GALT2(1), C1GALT1(1), CHPF(1), CHST1(2), CHST11(3), CHST13(3), CHST2(2), CHST3(3), CHST4(2), CHST6(2), CHSY1(4), DAD1(1), DPAGT1(2), EXT1(3), EXT2(3), EXTL1(4), EXTL2(2), EXTL3(1), FUT8(7), GALNT1(5), GALNT10(1), GALNT11(3), GALNT12(3), GALNT13(4), GALNT14(7), GALNT2(3), GALNT3(1), GALNT4(1), GALNT5(5), GALNT6(4), GALNT7(1), GALNT8(1), GALNT9(4), GALNTL1(1), GALNTL4(1), GALNTL5(1), GANAB(5), GCNT1(2), GCNT3(2), GCNT4(3), HS3ST1(3), HS3ST3A1(3), HS6ST2(4), HS6ST3(1), MAN1A1(3), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), MGAT5B(3), NDST1(2), NDST2(2), NDST3(4), NDST4(8), OGT(9), RPN1(1), RPN2(1), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST6GAL1(2), ST6GALNAC1(2), STT3B(2), UST(1), WBSCR17(11), XYLT1(3), XYLT2(3) 131029842 223 146 221 77 82 39 29 44 29 0 0.156 1.000 1.000 473 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 APH1A(2), CREBBP(13), CTBP1(5), CTBP2(4), DLL1(1), DLL3(1), DTX1(4), DTX2(1), DTX3L(2), DTX4(4), DVL1(1), DVL2(3), DVL3(3), EP300(6), HDAC2(7), HES1(1), JAG1(7), JAG2(5), LFNG(3), MAML1(6), MAML2(2), MAML3(4), MFNG(1), NCOR2(9), NCSTN(5), NOTCH1(52), NOTCH2(16), NOTCH3(7), NOTCH4(10), NUMB(1), NUMBL(2), PSEN1(1), RBPJ(7), RBPJL(5), SNW1(3) 82576085 204 139 190 55 45 31 21 39 64 4 0.128 1.000 1.000 474 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(5), ASH2L(2), CARM1(1), CTCFL(4), DOT1L(4), EHMT1(5), EHMT2(5), EZH1(2), EZH2(5), FBXO11(2), HCFC1(8), HSF4(2), JMJD4(2), JMJD6(4), KDM6A(6), MEN1(4), MLL(3), MLL2(10), MLL3(10), MLL5(1), NSD1(5), OGT(9), PAXIP1(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PRDM2(6), PRDM7(3), PRDM9(18), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), RBBP5(3), SATB1(3), SETD1A(4), SETD2(15), SETD7(2), SETD8(1), SETDB1(8), SETDB2(1), SETMAR(5), SMYD3(2), STK38(1), SUV39H1(2), SUV39H2(1), SUV420H1(3), SUZ12(2), WHSC1L1(4) 141487274 200 135 199 52 50 33 27 56 34 0 0.0414 1.000 1.000 475 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(2), BRAF(12), CHUK(1), CREB1(2), DAXX(5), ELK1(5), FOS(2), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP2K5(2), MAP3K1(9), MAP3K10(1), MAP3K11(1), MAP3K12(6), MAP3K13(3), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K6(1), MAP3K7(3), MAP3K8(4), MAP3K9(6), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(4), MAP4K5(1), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK4(2), MAPK7(6), MAPK8(2), MAPK9(2), MAPKAPK2(2), MAPKAPK3(2), MAPKAPK5(2), MAX(7), MEF2A(4), MEF2B(1), MEF2D(1), MKNK1(2), NFKB1(2), NFKBIA(3), PAK1(3), PAK2(2), RAC1(1), RAF1(2), RELA(1), RIPK1(4), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA5(2), RPS6KB1(2), RPS6KB2(3), SHC1(1), SP1(1), STAT1(4), TGFB2(2), TGFB3(1), TGFBR1(4), TRADD(1), TRAF2(2) 113253837 201 134 190 61 53 33 30 46 37 2 0.0856 1.000 1.000 476 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1C1(1), AKR1C2(1), AKR1C3(2), AKR1C4(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), CYP1A2(4), CYP1B1(2), CYP2B6(6), CYP2C18(3), CYP2C19(6), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP2S1(2), CYP3A4(5), CYP3A43(1), CYP3A7(6), EPHX1(4), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(3), GSTA5(4), GSTK1(2), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(9), UGT2A3(12), UGT2B10(7), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4) 68078240 188 131 186 56 60 24 27 59 18 0 0.0590 1.000 1.000 477 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(2), BCL2(3), CABIN1(11), CALM1(1), CALM3(1), CAMK4(3), CD3E(2), CD3G(1), CDKN1A(2), CEBPB(2), CNR1(1), CREBBP(13), CSF2(2), CSNK2A1(3), CSNK2B(3), CTLA4(1), EGR2(2), EGR3(2), EP300(6), FCER1A(4), FCGR3A(1), FOS(2), GATA3(3), GATA4(3), GSK3B(1), ICOS(1), IFNB1(2), IFNG(2), IL10(1), IL1B(3), IL3(2), IL6(2), ITK(1), KPNA5(4), MAPK8(2), MAPK9(2), MEF2A(4), MEF2B(1), MEF2D(1), MYF5(6), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB2(2), NFKBIE(3), NUP214(4), OPRD1(2), P2RX7(1), PAK1(3), PPP3CB(2), PPP3CC(1), PTPRC(9), RELA(1), RPL13A(2), SFN(3), SLA(2), SP1(1), SP3(5), TNF(1), TRAF2(2), TRPV6(14), VAV1(9), VAV2(4), VAV3(3), XPO5(1) 108096964 203 128 202 61 52 41 24 50 36 0 0.0310 1.000 1.000 478 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(3), ACVR1B(3), ACVR1C(3), ACVR2A(2), ACVRL1(6), AMHR2(2), BMP2(1), BMP4(3), BMP5(8), BMP6(3), BMPR1A(1), BMPR1B(1), BMPR2(1), CDKN2B(2), CHRD(2), COMP(1), CREBBP(13), CUL1(4), DCN(3), E2F4(1), E2F5(1), EP300(6), FST(1), GDF5(2), GDF6(2), GDF7(2), ID1(1), IFNG(2), INHBA(1), INHBB(1), INHBE(3), LEFTY2(4), LTBP1(7), MAPK1(4), MAPK3(2), NODAL(1), PITX2(7), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), RBL1(6), RBL2(3), RBX1(1), ROCK1(4), ROCK2(5), RPS6KB1(2), RPS6KB2(3), SMAD1(4), SMAD2(3), SMAD3(3), SMAD4(1), SMAD5(1), SMAD6(1), SMAD7(3), SMAD9(3), SMURF1(4), SMURF2(2), SP1(1), TFDP1(1), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNF(1), ZFYVE16(2), ZFYVE9(2) 117902449 214 128 214 56 60 34 33 55 31 1 0.00692 1.000 1.000 479 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), AGTR2(4), ATP8A1(5), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), CCKAR(1), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CX3CR1(3), CXCR4(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(3), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GNRHR(3), GPR77(1), GRPR(4), LHCGR(2), MC1R(3), MC2R(2), MC3R(6), MC4R(6), MC5R(5), NMBR(6), NPY1R(3), NPY2R(2), NPY5R(3), NTSR1(4), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), PPYR1(1), SSTR2(3), SSTR3(6), SSTR4(12), TACR2(2), TACR3(7), TRHR(2), TSHR(5) 62199268 166 125 166 70 75 22 25 37 7 0 0.293 1.000 1.000 480 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(18), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ADIPOR1(2), ADIPOR2(3), AGRP(1), AKT1(2), CAMKK1(2), CAMKK2(2), CD36(5), CHUK(1), CPT1A(2), CPT1C(2), CPT2(2), G6PC(8), G6PC2(1), IKBKB(2), IRS1(8), IRS2(1), IRS4(7), JAK1(3), JAK2(5), JAK3(5), LEPR(3), MAPK10(1), MAPK8(2), MAPK9(2), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), NPY(3), PCK1(6), PPARA(4), PPARGC1A(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(2), PRKAG3(2), PRKCQ(4), PTPN11(11), RELA(1), RXRA(4), RXRB(1), RXRG(3), SLC2A1(4), SLC2A4(1), STAT3(3), STK11(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2), TYK2(10) 98600563 191 122 189 69 59 35 11 55 30 1 0.285 1.000 1.000 481 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(2), CLK2(1), CLK3(3), CLK4(2), COL2A1(7), CPSF1(6), CPSF2(2), CPSF3(3), CSTF1(3), CSTF2(4), CSTF3(4), DDIT3(2), DDX20(1), DHX15(1), DHX16(4), DHX38(4), DHX8(8), DHX9(2), DICER1(7), FUS(4), LOC440563(2), METTL3(4), NCBP1(1), NCBP2(1), NONO(4), NUDT21(1), NXF1(1), PAPOLA(7), PHF5A(3), POLR2A(9), PRPF18(1), PRPF4(2), PRPF4B(4), PRPF8(12), PSKH1(1), PTBP1(3), RNGTT(4), SF3A1(2), SF3A2(1), SF3A3(2), SF3B1(8), SF3B2(2), SF3B4(1), SNRPA(1), SNRPB(2), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPE(1), SNRPF(1), SNURF(2), SPOP(4), SRPK1(3), SRPK2(2), SRRM1(3), SUPT5H(2), TXNL4A(1), U2AF1(3), U2AF2(3), XRN2(3) 125614794 181 118 180 43 56 26 23 46 29 1 0.0301 1.000 1.000 482 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(2), CALM1(1), CALM3(1), CHRM1(3), CHRNA1(4), FLT1(10), FLT4(8), KDR(14), NOS3(10), PDE2A(5), PDE3A(5), PDE3B(3), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKG1(2), PRKG2(6), RYR2(58), SLC7A1(3), SYT1(2), TNNI1(1) 48217166 143 116 142 43 53 24 26 26 14 0 0.0274 1.000 1.000 483 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(3), ARHGDIB(1), BAG4(1), BCL2(3), BIRC2(3), BIRC3(1), CASP2(1), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CRADD(2), CYCS(2), DAXX(5), DFFA(2), GSN(2), LMNA(2), LMNB2(3), MAP3K1(9), MAP3K5(4), MAPK8(2), MDM2(5), NFKB1(2), NFKBIA(3), NUMA1(12), PAK2(2), PRKCD(3), PRKDC(14), PSEN1(1), PTK2(2), RASA1(4), RB1(30), RELA(1), RIPK1(4), SPTAN1(8), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF1(1), TRAF2(2) 82353178 152 114 146 38 32 21 20 34 43 2 0.0399 1.000 1.000 484 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), ALG6(3), CCKBR(3), CCR2(2), CCR3(2), CCR5(1), CELSR1(13), CELSR2(14), CELSR3(17), CHRM2(3), CHRM3(4), EDNRA(1), EMR2(6), EMR3(2), F2R(2), FSHR(3), GHRHR(3), GNRHR(3), GPR116(12), GPR132(7), GPR133(7), GPR143(6), GPR17(2), GPR18(2), GPR61(4), GPR77(1), GPR84(2), GRM1(7), GRPR(4), HRH4(2), LGR6(1), LPHN2(8), LPHN3(7), LTB4R2(1), NTSR1(4), OR2M4(2), OR8G2(1), P2RY13(1), PTGFR(7), SMO(3), SSTR2(3), TAAR5(1), TSHR(5) 79258567 184 113 182 77 73 31 23 44 13 0 0.408 1.000 1.000 485 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(2), AKR1D1(1), ARSD(3), ARSE(6), CARM1(1), CYP11B1(3), CYP11B2(3), CYP19A1(2), HSD11B1(2), HSD17B3(1), HSD17B7(2), HSD17B8(1), HSD3B1(2), HSD3B2(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SRD5A1(2), SRD5A2(1), STS(2), SULT2A1(2), SULT2B1(3), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(9), UGT2A3(12), UGT2B10(7), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), WBSCR22(3) 59685024 148 107 145 47 41 22 26 46 13 0 0.109 1.000 1.000 486 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(6), ADCY6(2), ADCY8(3), CACNA1A(4), CACNA1B(15), GNAS(4), GNAT3(5), GNB1(1), GNB3(1), GRM4(6), ITPR3(18), KCNB1(5), PDE1A(3), PLCB2(7), PRKACG(1), PRKX(1), SCNN1A(1), SCNN1B(6), SCNN1G(6), TAS1R1(2), TAS1R2(5), TAS1R3(1), TAS2R1(5), TAS2R10(3), TAS2R13(1), TAS2R16(5), TAS2R3(1), TAS2R38(1), TAS2R39(1), TAS2R4(2), TAS2R40(2), TAS2R41(5), TAS2R42(1), TAS2R46(1), TAS2R5(2), TAS2R60(1), TAS2R7(1), TAS2R9(4), TRPM5(4) 67850887 143 107 142 54 62 21 15 28 17 0 0.348 1.000 1.000 487 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(1), BMP4(3), BMP5(8), BMP6(3), BTRC(2), CSNK1A1(2), CSNK1A1L(2), CSNK1D(2), CSNK1E(1), CSNK1G1(2), CSNK1G2(2), CSNK1G3(1), DHH(1), FBXW11(1), GLI1(6), GLI2(5), GLI3(6), GSK3B(1), HHIP(3), IHH(3), LRP2(37), PRKACG(1), PRKX(1), PTCH1(3), PTCH2(2), RAB23(2), SHH(3), SMO(3), STK36(2), SUFU(4), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2(8), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2), ZIC2(1) 72435790 147 105 146 44 62 22 18 26 19 0 0.0517 1.000 1.000 488 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACADL(1), ACADM(2), ACOX1(2), ACOX2(3), ACOX3(3), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ANGPTL4(1), APOA1(1), APOA5(1), AQP7(4), CD36(5), CPT1A(2), CPT1C(2), CPT2(2), CYP27A1(2), CYP4A11(5), CYP4A22(2), CYP7A1(3), CYP8B1(3), DBI(1), EHHADH(2), FABP1(1), FABP4(1), FABP6(2), FABP7(1), FADS2(2), GK(3), GK2(5), HMGCS2(3), ILK(1), LPL(2), ME1(2), MMP1(3), NR1H3(5), OLR1(2), PCK1(6), PLTP(1), PPARA(4), PPARG(3), RXRA(4), RXRB(1), RXRG(3), SCD(1), SCP2(1), SLC27A1(4), SLC27A2(8), SLC27A4(1), SLC27A5(4), SLC27A6(4), SORBS1(3), UBC(8) 77675011 153 101 150 54 47 28 17 41 20 0 0.234 1.000 1.000 489 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ABP1(4), ACAT2(1), ACMSD(2), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), AOC2(1), AOX1(9), ASMT(2), CAT(3), CYP19A1(2), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(6), CYP2C18(3), CYP2C19(6), CYP2C8(4), CYP2C9(3), CYP2D6(2), CYP2E1(2), CYP2F1(1), CYP3A4(5), CYP3A7(6), CYP4B1(5), CYP4F8(3), CYP51A1(2), DDC(5), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), KMO(4), KYNU(2), MAOA(3), MAOB(2), SDS(1), TDO2(2), TPH1(5), WARS(1), WARS2(2) 65351752 137 98 134 46 62 17 11 30 17 0 0.174 1.000 1.000 490 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS1(2), ALAS2(1), BLVRA(2), COX10(5), COX15(1), CP(7), EARS2(1), EPRS(5), FECH(2), FTH1(3), FTMT(4), GUSB(3), HCCS(5), HMBS(1), HMOX1(1), MMAB(3), PPOX(2), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(9), UGT2A3(12), UGT2B10(7), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), UROD(1), UROS(1) 50118509 134 97 132 35 37 17 25 48 7 0 0.0476 1.000 1.000 491 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(4), CAD(8), CANT1(4), CDA(3), CTPS2(2), DCK(2), DCTD(1), DHODH(2), DPYD(6), DPYS(5), DTYMK(1), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), NME7(2), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(3), NT5M(1), NUDT2(1), PNPT1(1), POLA1(3), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1), PRIM1(2), PRIM2(2), RRM1(3), RRM2(1), RRM2B(1), TK2(3), TXNRD1(1), TXNRD2(6), UCK1(4), UMPS(1), UPP1(3), UPP2(3), UPRT(2) 96254638 156 96 155 47 33 28 21 50 24 0 0.171 1.000 1.000 492 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(4), ACYP1(1), ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDH7A1(2), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), G6PC(8), G6PC2(1), GALM(1), GAPDH(1), GAPDHS(2), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKL(5), PFKP(1), PGAM2(1), PGAM4(2), PGK1(3), PGK2(1), PGM1(1), PGM3(1), PKLR(4), TPI1(1) 69075635 138 91 136 37 53 26 10 34 15 0 0.00594 1.000 1.000 493 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CD28(2), CD3D(1), CSK(2), CTLA4(1), DAG1(3), DTYMK(1), EPHB2(5), FBXW7(6), GRAP2(2), ITK(1), LAT(2), LCK(1), LCP2(1), MAPK1(4), NCK1(2), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PLCG1(12), PTPRC(9), RAF1(2), RASGRP1(2), RASGRP2(3), RASGRP3(2), RASGRP4(3), SOS1(7), SOS2(5), VAV1(9), ZAP70(8) 66328255 130 90 126 30 37 25 15 32 21 0 0.00988 1.000 1.000 494 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPS(3), CDS2(2), CHAT(7), CHKB(1), CLC(1), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(2), ETNK1(1), GNPAT(2), GPD2(1), LCAT(1), LGALS13(4), LYPLA1(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(2), PCYT1B(2), PISD(2), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB2(7), PLCG1(12), PLCG2(12), PPAP2A(2), PPAP2C(1) 59366754 124 88 121 32 40 26 12 29 17 0 0.0134 1.000 1.000 495 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), AANAT(2), ABP1(4), ACAT2(1), ACMSD(2), AFMID(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AOC2(1), AOX1(9), ASMT(2), CARM1(1), CAT(3), CYP1A2(4), CYP1B1(2), DDC(5), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), HSD17B4(3), KMO(4), KYNU(2), LCMT1(3), LCMT2(2), LNX1(4), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), NFX1(3), OGDH(1), OGDHL(7), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), TDO2(2), TPH1(5), TPH2(2), WARS(1), WARS2(2), WBSCR22(3) 71939912 132 86 129 45 50 17 13 33 19 0 0.244 1.000 1.000 496 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTG2(2), ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), CFL1(1), CFL2(2), FLNA(18), FLNC(15), FSCN1(2), FSCN2(2), FSCN3(3), GDI1(4), GDI2(1), LIMK1(4), MYH2(25), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), ROCK1(4), ROCK2(5), RPS4X(3), VASP(1), WASF1(1), WASL(2) 57053538 131 85 126 42 57 17 15 27 14 1 0.0597 1.000 1.000 497 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(4), ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), AOX1(9), CARM1(1), DBH(4), DCT(1), DDC(5), ECH1(1), ESCO1(2), ESCO2(2), FAH(2), GOT1(2), GOT2(1), GSTZ1(3), HGD(5), HPD(1), LCMT1(3), LCMT2(2), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), PNPLA3(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SH3GLB1(3), TAT(3), TH(3), TPO(10), TYR(5), TYRP1(6), WBSCR22(3) 70627373 137 84 131 38 51 19 14 37 16 0 0.0291 1.000 1.000 498 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPP(7), ALPPL2(6), ASCC3(7), ATP13A2(3), DDX18(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(5), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(4), DHFR(1), DHX58(2), ENTPD7(2), EP400(9), ERCC2(3), ERCC3(2), FPGS(2), GGH(1), IFIH1(3), MOV10L1(7), QDPR(2), RAD54B(5), RAD54L(6), RUVBL2(4), SETX(5), SKIV2L2(3), SMARCA2(5), SMARCA5(3), SPR(1) 74571237 121 84 119 42 40 23 14 27 17 0 0.390 1.000 1.000 499 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), G6PC(8), GAPDH(1), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKP(1), PGK1(3), PGM1(1), PGM3(1), PKLR(4), TPI1(1) 57967625 118 81 116 35 46 26 8 27 11 0 0.0315 1.000 1.000 500 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), G6PC(8), GAPDH(1), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKP(1), PGK1(3), PGM1(1), PGM3(1), PKLR(4), TPI1(1) 57967625 118 81 116 35 46 26 8 27 11 0 0.0315 1.000 1.000 501 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(1), ALOX12B(2), ALOX15(2), ALOX15B(1), ALOX5(2), CBR1(2), CBR3(1), CYP2B6(6), CYP2C18(3), CYP2C19(6), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP2U1(2), CYP4A11(5), CYP4A22(2), CYP4F2(3), CYP4F3(6), DHRS4(1), EPHX2(2), GGT1(3), GPX1(1), GPX2(2), GPX4(2), GPX5(1), GPX6(1), LTA4H(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PTGES(1), PTGES2(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(2) 46240610 103 80 102 33 37 15 9 25 17 0 0.150 1.000 1.000 502 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(3), AXIN1(4), CCND1(4), CCND2(2), CCND3(1), CSNK1E(1), CTNNB1(3), DVL1(1), DVL2(3), DVL3(3), FZD1(3), FZD10(5), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GSK3B(1), LDLR(3), MAPK10(1), MAPK9(2), PAFAH1B1(4), PLAU(1), PPP2R5C(1), PPP2R5E(3), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(4), PRKCI(2), PRKCQ(4), PRKD1(1), RAC1(1), SFRP4(1), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2(8), WNT2B(2), WNT3(1), WNT5B(2), WNT7A(2) 71389252 112 80 111 35 39 11 16 22 22 2 0.132 1.000 1.000 503 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(15), CDR1(1), DGKI(2), FAU(1), IL6ST(3), MRPL19(2), RPL10(6), RPL11(2), RPL13A(2), RPL15(2), RPL18A(1), RPL23(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL36(1), RPL3L(1), RPL5(10), RPL6(1), RPL7(3), RPL7A(1), RPLP0(1), RPS11(1), RPS12(2), RPS18(2), RPS19(1), RPS2(1), RPS21(1), RPS24(1), RPS3(3), RPS4X(3), RPS5(1), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(3), RPSA(2), SLC36A2(3), TBC1D10C(3), TSPAN9(1), UBA52(1), UBC(8) 62298500 119 77 118 29 28 18 15 33 25 0 0.131 1.000 1.000 504 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CALR(2), CANX(2), CD4(2), CD8A(1), CIITA(4), CREB1(2), CTSB(4), CTSS(1), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(5), HLA-DOA(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(3), HLA-G(2), HSP90AA1(1), HSP90AB1(3), IFI30(1), IFNA10(2), IFNA21(5), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), KIR2DL1(6), KIR2DL3(2), KIR2DL4(1), KIR3DL1(1), KIR3DL2(5), KIR3DL3(1), KLRC1(3), KLRC2(5), KLRD1(1), LGMN(1), NFYA(1), NFYB(1), PDIA3(1), PSME1(3), RFX5(2), RFXANK(1), TAP1(2), TAP2(4) 55046101 104 74 103 42 27 17 14 29 17 0 0.643 1.000 1.000 505 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(6), ACTB(2), ACTG1(1), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(3), EZR(4), FYN(2), HCLS1(4), ITGB1(3), KRT18(3), LY96(2), NCK1(2), NCL(3), OCLN(3), PRKCA(6), ROCK1(4), ROCK2(5), TLR4(2), TLR5(4), TUBA1A(3), TUBA1B(1), TUBA3C(11), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3), WAS(3), WASL(2), YWHAQ(1), YWHAZ(1) 62422498 108 74 108 37 42 17 17 19 12 1 0.159 1.000 1.000 506 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(6), ACTB(2), ACTG1(1), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(3), EZR(4), FYN(2), HCLS1(4), ITGB1(3), KRT18(3), LY96(2), NCK1(2), NCL(3), OCLN(3), PRKCA(6), ROCK1(4), ROCK2(5), TLR4(2), TLR5(4), TUBA1A(3), TUBA1B(1), TUBA3C(11), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3), WAS(3), WASL(2), YWHAQ(1), YWHAZ(1) 62422498 108 74 108 37 42 17 17 19 12 1 0.159 1.000 1.000 507 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), CDS2(2), CHAT(7), CHKB(1), CRLS1(1), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(2), ESCO1(2), ESCO2(2), ETNK1(1), ETNK2(2), GNPAT(2), GPAM(1), GPD2(1), LCAT(1), LYPLA1(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PISD(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLD1(8), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(5), SH3GLB1(3) 77903633 112 73 111 26 39 25 10 26 12 0 0.00471 1.000 1.000 508 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(3), ASAH1(2), CAV3(1), DAG1(3), DLG4(6), EPHB2(5), GNAI1(4), ITPR1(9), ITPR2(15), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), PITX2(7), PTX3(2), RAC1(1), RYR1(15) 54509157 105 73 105 32 33 19 21 19 12 1 0.0624 1.000 1.000 509 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(4), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH4A1(2), AMD1(2), AOC2(1), ARG2(2), ASL(2), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), DAO(3), GAMT(1), GATM(2), GLUD1(4), GOT1(2), GOT2(1), MAOA(3), MAOB(2), NOS1(10), NOS3(10), OAT(1), ODC1(3), OTC(2), P4HA1(1), P4HB(1), RARS(3), SMS(2) 52591328 103 70 103 36 41 18 11 23 10 0 0.234 1.000 1.000 510 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(2), ADCY3(5), ADCY9(11), AK1(1), ARF1(1), ARF6(1), ARL4D(1), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), ERO1L(1), GNAS(4), PDIA4(3), PLCG1(12), PLCG2(12), PRKCA(6), SEC61A1(1), TRIM23(3) 43932351 88 70 86 33 33 18 9 15 12 1 0.415 1.000 1.000 511 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(8), CANT1(4), CDA(3), CTPS2(2), DCK(2), DCTD(1), DHODH(2), DPYD(6), DPYS(5), DTYMK(1), ENTPD1(3), NT5C(3), NT5E(3), NT5M(1), NUDT2(1), POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3), RRM1(3), RRM2(1), TK2(3), TXNRD1(1), UCK1(4), UMPS(1), UPP1(3) 68133374 109 70 108 38 23 20 13 39 14 0 0.566 1.000 1.000 512 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(1), ELK1(5), FOS(2), IKBKB(2), IRAK1(3), LY96(2), MAP2K3(6), MAP3K1(9), MAP3K7(3), MAPK8(2), NFKB1(2), NFKBIA(3), PPARA(4), RELA(1), TLR10(7), TLR2(5), TLR3(6), TLR4(2), TLR6(8), TLR7(10), TLR9(5), TOLLIP(1) 43409096 90 70 85 32 30 18 12 21 9 0 0.312 1.000 1.000 513 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(7), ATP4A(6), ATP4B(2), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5I(1), ATP6AP1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), COX10(5), COX15(1), COX17(1), COX6B1(1), COX7A1(1), COX7B(3), COX7B2(1), COX7C(1), LHPP(1), NDUFA10(4), NDUFA12(1), NDUFA3(2), NDUFA4(1), NDUFA7(1), NDUFA9(4), NDUFB1(1), NDUFB11(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), NDUFV3(2), PPA2(1), SDHA(4), SDHC(2), TCIRG1(2), UQCRC1(4), UQCRC2(1), UQCRH(2), UQCRQ(1) 66250051 107 68 105 32 25 17 19 30 15 1 0.163 1.000 1.000 514 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(4), AGXT(2), AGXT2(2), ALAS1(2), ALAS2(1), AMT(3), AOC2(1), ATP6V0C(1), CBS(5), CHKB(1), CTH(2), DAO(3), DLD(3), DMGDH(4), GAMT(1), GARS(3), GATM(2), GCAT(2), GLDC(3), MAOA(3), MAOB(2), PISD(2), PLCB2(7), PLCG1(12), PLCG2(12), PSPH(2), SARDH(3), SARS(1), SHMT1(2), TARS(1) 49994814 92 64 90 29 31 22 5 24 10 0 0.0917 1.000 1.000 515 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(4), ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), AOX1(9), DBH(4), DCT(1), DDC(5), FAH(2), GOT1(2), GOT2(1), GSTZ1(3), HGD(5), HPD(1), MAOA(3), MAOB(2), TAT(3), TH(3), TPO(10), TYR(5) 37648718 94 64 91 30 43 10 8 27 6 0 0.0949 1.000 1.000 516 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(6), CARM1(1), CCND1(4), CREBBP(13), EP300(6), ERCC3(2), ESR1(3), GRIP1(9), GTF2E1(3), GTF2F1(1), HDAC2(7), HDAC3(1), HDAC4(4), HDAC5(1), HDAC6(4), NCOR2(9), NR0B1(1), NRIP1(4), PELP1(2), POLR2A(9), TBP(2) 54982332 92 63 91 31 31 14 7 21 19 0 0.396 1.000 1.000 517 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), ELK1(5), FPR1(1), GNA15(1), GNB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAPK1(4), MAPK3(2), NCF1(3), NCF2(5), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKBIA(3), PAK1(3), PIK3C2G(10), PLCB1(4), PPP3CA(1), PPP3CB(2), PPP3CC(1), RAC1(1), RAF1(2), RELA(1), SYT1(2) 45574438 92 63 89 35 28 13 13 18 19 1 0.394 1.000 1.000 518 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(3), ACADL(1), ACADM(2), ACADS(5), ACADVL(3), ACAT2(1), ACOX1(2), ACOX3(3), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CPT1A(2), CPT1C(2), CPT2(2), CYP4A11(5), CYP4A22(2), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), HSD17B4(3) 58123325 97 62 95 40 28 13 9 27 20 0 0.658 1.000 1.000 519 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALNT1(2), B3GALT1(2), B3GALT2(1), B3GALT5(2), B3GNT2(1), B3GNT3(4), B3GNT4(2), B3GNT5(4), B4GALNT1(3), B4GALT2(1), B4GALT6(2), FUT2(2), FUT3(2), FUT4(1), FUT5(6), FUT6(3), FUT7(1), GBGT1(2), GCNT2(2), PIGA(3), PIGB(1), PIGC(1), PIGF(1), PIGG(1), PIGN(2), PIGO(5), PIGQ(3), PIGS(2), PIGT(1), PIGU(2), PIGX(1), PIGZ(2), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST3GAL6(5), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3), UGCG(2) 57723749 95 62 95 35 33 11 8 29 14 0 0.595 1.000 1.000 520 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG2(2), ASL(2), ASS1(4), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), DAO(3), EPRS(5), GAMT(1), GATM(2), GLUD1(4), GLUD2(4), GOT1(2), GOT2(1), LAP3(1), NOS1(10), NOS3(10), OAT(1), OTC(2), P4HA1(1), PARS2(2), PRODH(1), RARS(3), RARS2(4) 42713639 86 61 85 32 33 14 11 20 8 0 0.442 1.000 1.000 521 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), ARHGEF11(4), BCL2(3), DLG4(6), GNA13(1), LPA(11), MAP3K1(9), MAP3K5(4), MAPK8(2), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PDK1(2), PHKA2(5), PI3(2), PIK3CB(7), PLD1(8), PLD3(1), PTK2(2), RDX(5), ROCK1(4), ROCK2(5), SERPINA4(2), SRF(3), TBXA2R(1) 58323241 99 60 97 32 25 22 14 26 11 1 0.285 1.000 1.000 522 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(1), ARHGAP1(1), ARHGAP4(4), ARHGAP5(5), ARHGAP6(4), ARHGEF1(1), ARHGEF11(4), ARHGEF5(3), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(1), BAIAP2(3), CFL1(1), DIAPH1(5), GSN(2), LIMK1(4), MYL2(2), MYLK(7), OPHN1(6), PIP5K1B(3), PPP1R12B(1), ROCK1(4), SRC(2), TLN1(5), VCL(1) 54094464 76 57 75 31 18 10 10 27 11 0 0.743 1.000 1.000 523 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(3), AKT1(2), DAG1(3), ITPR1(9), ITPR2(15), ITPR3(18), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PDK1(2), PHKA2(5), PIK3CB(7), PITX2(7), PLD1(8), PLD3(1) 53359498 90 57 90 33 28 18 14 22 6 2 0.297 1.000 1.000 524 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(5), CALCR(9), CALCRL(1), CD97(3), CRHR2(5), ELTD1(6), EMR1(5), EMR2(6), GHRHR(3), GIPR(2), GLP1R(2), GLP2R(3), GPR64(4), LPHN1(2), LPHN2(8), LPHN3(7), SCTR(1), VIPR1(1), VIPR2(2) 31811074 75 56 74 31 25 9 14 23 4 0 0.635 1.000 1.000 525 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(1), AASS(1), ACAT2(1), AKR1B10(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), DOT1L(4), ECHS1(3), EHHADH(2), EHMT1(5), EHMT2(5), GCDH(1), HADHA(3), HSD17B4(3), HSD3B7(1), NSD1(5), OGDH(1), OGDHL(7), PIPOX(2), PLOD1(3), PLOD2(2), PLOD3(1), SETD1A(4), SETD7(2), SETDB1(8), SHMT1(2), SUV39H1(2), SUV39H2(1), TMLHE(2) 69034345 94 56 94 43 35 12 9 24 14 0 0.812 1.000 1.000 526 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(2), AKR1D1(1), ARSD(3), ARSE(6), CYP11B1(3), CYP11B2(3), HSD11B1(2), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), SRD5A1(2), SRD5A2(1), STS(2), SULT2A1(2), UGT1A1(13), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(3), UGT2B4(9) 32485666 67 54 66 27 23 12 10 17 5 0 0.412 1.000 1.000 527 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAX(1), BCL2(3), BCL2A1(1), BOK(1), CASP1(8), CASP10(2), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CD40(1), CD40LG(2), CRADD(2), CYCS(2), DAXX(5), DFFA(2), FAS(1), FASLG(1), IKBKE(5), MCL1(1), NFKB1(2), NFKBIA(3), NGFR(1), NR3C1(3), NTRK1(4), PTPN13(4), RIPK1(4), TFG(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF1(1), TRAF2(2), TRAF3(1) 51772317 78 54 78 29 21 13 5 21 18 0 0.575 1.000 1.000 528 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDK2(1), CDT1(1), DIAPH2(5), GMNN(1), MCM10(4), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), NACA(6), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), PRIM1(2), RFC1(2), RFC4(4), RPA1(3), RPA2(1), RPA4(2), UBA52(1), UBC(8) 60300898 87 52 87 36 15 12 11 30 19 0 0.833 1.000 1.000 529 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(19), C5(7), C6(4), C7(5), ICAM1(3), IL1A(1), IL6(2), ITGA4(8), ITGAL(2), ITGB1(3), ITGB2(5), SELP(4), SELPLG(3), TNF(1), VCAM1(2) 29462150 69 52 69 32 20 9 10 18 12 0 0.733 1.000 1.000 530 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(3), EEF1A2(1), EEF1B2(1), EEF1D(3), EEF2(2), EEF2K(2), EIF1AX(4), EIF2AK1(1), EIF2AK2(1), EIF2AK3(3), EIF2B1(1), EIF2B4(1), EIF2S2(2), EIF2S3(2), EIF4A1(7), EIF4A2(2), EIF4E(2), EIF4G1(5), EIF4G3(7), EIF5A(1), EIF5B(1), GSPT2(6), PABPC1(4), PABPC3(5), PAIP1(1), SLC35A4(1) 52195259 69 50 68 26 17 10 6 23 13 0 0.735 1.000 1.000 531 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(1), DARS(1), DARS2(2), EARS2(1), EPRS(5), FARS2(3), FARSA(1), GARS(3), HARS(4), HARS2(1), IARS(4), IARS2(3), KARS(2), LARS(4), MARS(7), MARS2(2), MTFMT(1), NARS(1), NARS2(1), PARS2(2), QARS(5), RARS(3), RARS2(4), SARS(1), SARS2(2), TARS(1), TARS2(2), VARS(4), VARS2(3), WARS(1), WARS2(2), YARS(1), YARS2(1) 64422010 83 49 83 23 11 19 11 29 13 0 0.309 1.000 1.000 532 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A2(1), GTF2E1(3), GTF2F1(1), GTF2H1(3), GTF2H4(2), GTF2IRD1(4), STON1(2), TAF1(12), TAF10(1), TAF1L(13), TAF2(6), TAF4(5), TAF4B(3), TAF5L(2), TAF6(2), TAF6L(1), TAF7(1), TAF7L(6), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(2) 42817761 74 49 74 23 17 11 8 25 12 1 0.453 1.000 1.000 533 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(3), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC4(2), ANAPC5(5), ANAPC7(2), BTRC(2), CDC16(2), CDC20(1), CDC23(4), CDC27(5), CUL1(4), CUL2(7), CUL3(1), FBXW11(1), FBXW7(6), FZR1(4), ITCH(1), RBX1(1), SKP2(4), SMURF1(4), SMURF2(2), UBE2D4(2), UBE2E3(1), WWP1(3), WWP2(2) 47872334 73 49 73 27 18 11 13 22 9 0 0.696 1.000 1.000 534 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(1), CREB1(2), CREB3(3), DUSP1(1), DUSP10(2), EEF2K(2), EIF4E(2), ELK1(5), IL1R1(4), MAP2K3(6), MAP3K10(1), MAP3K4(7), MAP3K5(4), MAP3K7(3), MAPK1(4), MAPK12(2), MAPK13(2), MAPKAPK2(2), MAPKAPK5(2), MKNK1(2), MYEF2(3), NFKB1(2), NR2C2(3), SRF(3) 39621956 70 49 70 25 19 11 15 15 10 0 0.465 1.000 1.000 535 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(7), APOA1(1), APOA4(3), APOE(2), CETP(3), CYP7A1(3), DGAT1(2), LCAT(1), LDLR(3), LIPC(1), LPL(2), LRP1(29), SCARB1(2), SOAT1(5) 32505871 64 48 64 25 15 11 6 20 12 0 0.694 1.000 1.000 536 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(6), GABBR1(2), GPRC5C(1), GPRC5D(2), GRM1(7), GRM2(4), GRM3(16), GRM4(6), GRM5(6), GRM7(5), GRM8(7) 24925941 62 47 60 40 34 5 3 15 5 0 0.973 1.000 1.000 537 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(3), ALG12(2), ALG13(4), ALG14(1), ALG3(4), ALG5(3), ALG6(3), B4GALT2(1), DAD1(1), DHDDS(1), DPAGT1(2), DPM1(3), FUT8(7), GANAB(5), MAN1A1(3), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), MGAT5B(3), RPN1(1), RPN2(1), ST6GAL1(2), STT3B(2) 50341004 73 45 73 26 18 19 10 10 16 0 0.396 1.000 1.000 538 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAA2(3), ACAD8(4), ACAD9(1), ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1B10(3), AKR1C4(2), AKR1D1(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), BAAT(1), CEL(4), CYP27A1(2), CYP7A1(3), HSD3B7(1), LIPA(2), SLC27A5(4), SOAT1(5), SOAT2(1), SRD5A1(2), SRD5A2(1) 37576345 76 44 76 32 20 11 9 30 6 0 0.772 1.000 1.000 539 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR7(1), CD28(2), CD4(2), CSF2(2), CXCR4(2), IFNG(2), IFNGR1(1), IFNGR2(4), IL12B(4), IL12RB1(4), IL12RB2(4), IL18R1(4), IL4R(9), IL5(1), TGFB2(2), TGFB3(1) 23771415 54 43 53 24 20 3 8 16 7 0 0.695 1.000 1.000 540 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(3), AXIN1(4), CREBBP(13), CTNNB1(3), DVL1(1), EP300(6), FZD1(3), GSK3B(1), LDB1(2), LEF1(1), PITX2(7), TRRAP(18), WNT1(1) 39411320 63 43 63 25 16 9 9 17 12 0 0.680 1.000 1.000 541 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(3), ACTN2(6), ACTN3(1), BCAR1(3), BCR(3), CAPN1(2), CAPNS1(2), CAPNS2(1), CRKL(2), CSK(2), FYN(2), ITGA1(4), ITGB1(3), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MAPK8(2), PPP1R12B(1), PTK2(2), PXN(1), RAF1(2), ROCK1(4), SHC1(1), SOS1(7), SRC(2), TLN1(5), VCL(1), ZYX(2) 56050622 72 42 72 19 22 11 14 17 7 1 0.0867 1.000 1.000 542 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1QB(1), C1R(2), C1S(5), C2(2), C3(19), C5(7), C6(4), C7(5), C8A(4), C8B(7), C9(2), MASP1(2) 24743881 62 40 62 28 21 10 4 19 8 0 0.778 1.000 1.000 543 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(3), ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), FPGT(1), GMDS(1), GMPPA(2), HK1(4), HK2(5), HK3(5), HSD3B7(1), LHPP(1), MPI(1), MTMR1(6), MTMR2(3), MTMR6(1), PFKFB1(6), PFKFB2(2), PFKFB3(2), PFKFB4(1), PFKL(5), PFKP(1), PGM2(4), PMM1(1), SORD(1), TPI1(1), TSTA3(1) 44206222 67 40 67 26 29 11 6 12 9 0 0.404 1.000 1.000 544 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ACAA2(3), ADH1A(3), ADH1B(4), ADH1C(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1C4(2), AKR1D1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), BAAT(1), CEL(4), CYP27A1(2), CYP7A1(3), SOAT2(1), SRD5A1(2), SRD5A2(1) 27602759 57 39 57 25 18 9 6 20 4 0 0.705 1.000 1.000 545 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1QB(1), C1R(2), C1S(5), C2(2), C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2), MASP1(2), MASP2(1), MBL2(4) 25330880 60 39 60 25 20 7 5 19 9 0 0.708 1.000 1.000 546 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(6), ICAM1(3), ITGA4(8), ITGAL(2), ITGAM(7), ITGB1(3), ITGB2(5), SELE(8), SELP(4) 18965826 46 39 45 25 18 5 10 8 5 0 0.809 1.000 1.000 547 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(2), ANXA3(3), ANXA5(1), ANXA6(3), CYP11A1(7), EDNRA(1), EDNRB(1), HPGD(1), HSD11B1(2), PLA2G4A(7), PRL(1), PTGER4(2), PTGFR(7), PTGIS(2), PTGS1(3), PTGS2(3), SCGB1A1(1), TBXAS1(2) 24524396 51 38 51 22 16 5 4 16 10 0 0.734 1.000 1.000 548 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(2), CLOCK(3), CRY1(3), DNAJA1(3), EIF4G2(1), ETV6(4), GFRA1(1), HERPUD1(2), HSPA8(3), IDI1(2), KLF9(3), MYF6(2), NCKAP1(5), NCOA4(3), NR1D2(1), PER1(6), PER2(6), PIGF(1), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(2), TOB1(1), UGP2(1), ZFR(3) 43503986 62 37 61 21 14 11 9 21 7 0 0.542 1.000 1.000 549 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(3), POLA2(2), POLB(3), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLG(1), POLH(1), POLI(5), POLK(2), POLL(2), POLM(3), POLQ(7), PRIM1(2), PRIM2(2), REV1(5), REV3L(8) 48288701 63 37 63 22 16 8 7 22 10 0 0.734 1.000 1.000 550 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(2), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(9), MAP3K7(3), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TLR4(2), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(3), TRADD(1) 28972291 43 37 41 21 15 12 4 6 6 0 0.754 1.000 1.000 551 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(3), AASDHPPT(1), AASS(1), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ATP6V0C(1), DOT1L(4), ECHS1(3), EHHADH(2), EHMT1(5), EHMT2(5), GCDH(1), HADHA(3), PLOD1(3), PLOD2(2), PLOD3(1), SDS(1), SHMT1(2), TMLHE(2) 44051689 62 36 62 32 26 10 7 10 9 0 0.794 1.000 1.000 552 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(1), CHUK(1), CRADD(2), IKBKB(2), MAP2K3(6), MAP3K1(9), MAP4K2(1), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TANK(3), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2) 28720723 43 36 41 20 14 11 3 7 8 0 0.748 1.000 1.000 553 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1QB(1), C1R(2), C1S(5), C2(2), C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2) 20838544 53 35 53 22 18 5 4 18 8 0 0.739 1.000 1.000 554 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(2), DERA(1), FBP1(3), FBP2(2), G6PD(3), GPI(2), H6PD(3), PFKL(5), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(3), PRPS2(5), RBKS(1), RPE(1), RPIA(1), TALDO1(2), TKT(2), TKTL1(1), TKTL2(3) 28876038 47 35 47 21 21 9 2 7 8 0 0.540 1.000 1.000 555 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), CHUK(1), IFNG(2), IKBKB(2), MAP3K1(9), MAP3K5(4), MAP4K5(1), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), TNFRSF9(4), TNFSF9(5), TRAF2(2) 23034618 40 34 35 16 11 8 6 4 11 0 0.604 1.000 1.000 556 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(3), ASNS(4), CA1(1), CA12(3), CA13(1), CA14(1), CA2(1), CA5A(1), CA6(1), CA9(1), CPS1(8), CTH(2), GLS(3), GLS2(1), GLUD1(4), GLUD2(4), GLUL(2), HAL(3) 25221894 44 34 44 16 15 8 3 12 6 0 0.516 1.000 1.000 557 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), CDK7(1), ERCC3(2), GTF2A2(1), GTF2E1(3), GTF2H1(3), GTF2H4(2), ILK(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3B(3), POLR3D(1), POLR3E(1), POLR3K(1), TAF6(2), TAF7(1), TAF9(2), TBP(2) 41585824 54 33 54 31 12 10 6 18 8 0 0.982 1.000 1.000 558 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM3(1), CCL2(1), CCR5(1), CXCR4(2), FOS(2), MAPK8(2), PLCG1(12), PRKCA(6), PTK2B(5), SYT1(2) 16358037 35 32 33 14 8 7 7 8 4 1 0.452 1.000 1.000 559 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(3), ELK1(5), FOS(2), IL2RB(2), JAK1(3), JAK3(5), LCK(1), MAP2K1(1), MAPK3(2), MAPK8(2), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2) 27812961 39 32 39 17 8 7 4 11 8 1 0.734 1.000 1.000 560 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(2), GTF2E1(3), GTF2F1(1), HDAC3(1), NCOA1(3), NCOA2(5), NCOA3(4), NCOR2(9), POLR2A(9), RXRA(4), TBP(2) 29674222 43 32 42 24 8 8 1 14 12 0 0.974 1.000 1.000 561 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(3), EXTL1(4), EXTL2(2), EXTL3(1), HS3ST1(3), HS3ST3A1(3), HS6ST2(4), HS6ST3(1), NDST1(2), NDST2(2), NDST3(4), NDST4(8) 24655154 40 31 39 16 18 2 10 9 1 0 0.589 1.000 1.000 562 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(6), ICAM1(3), ITGA4(8), ITGAL(2), ITGB1(3), ITGB2(5), SELE(8) 14402972 35 31 34 19 13 5 8 4 5 0 0.755 1.000 1.000 563 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(3), BIRC3(1), CASP8(2), CFLAR(1), MAP3K3(2), MAP3K7(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), NR2C2(3), RALBP1(3), RIPK1(4), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2) 32344243 43 31 43 16 14 8 6 9 6 0 0.541 1.000 1.000 564 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(9), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TANK(3), TNFAIP3(2), TNFRSF1B(3), TRAF1(1), TRAF2(2), TRAF3(1) 26666594 38 31 36 16 15 8 2 7 6 0 0.559 1.000 1.000 565 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2) 14944859 41 30 41 19 14 3 4 12 8 0 0.812 1.000 1.000 566 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(5), CR2(8), HLA-DRA(4), HLA-DRB1(1), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9) 18066385 37 30 37 19 14 7 1 9 6 0 0.816 1.000 1.000 567 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(1), AP2M1(1), ARF1(1), BTK(3), EEA1(3), GRASP(1), GSK3B(1), LYN(2), PFKL(5), PFKP(1), PLCG1(12), PRKCE(1), RAC1(1), RPS6KB1(2), VAV2(4) 29672394 41 30 39 20 10 11 6 8 6 0 0.729 1.000 1.000 568 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(2), CBS(5), CTH(2), DNMT1(3), DNMT3A(11), DNMT3B(4), MARS(7), MARS2(2), MAT1A(2), MTFMT(1), MTR(2), SRM(2), TAT(3) 24608089 46 29 45 18 13 9 3 13 6 2 0.494 1.000 1.000 569 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT2(1), B3GNT3(4), B3GNT4(2), B3GNT5(4), B4GALT2(1), FUT2(2), FUT3(2), FUT4(1), FUT5(6), FUT6(3), FUT7(1), GCNT2(2), ST3GAL6(5), ST8SIA1(2) 19221009 37 29 37 15 13 5 3 10 6 0 0.694 1.000 1.000 570 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(3), GLB1(2), HEXA(1), HEXB(1), LCT(13), SLC33A1(4), ST3GAL1(3), ST3GAL2(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3) 19559789 38 27 38 17 14 3 4 8 9 0 0.857 1.000 1.000 571 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(6), ICAM1(3), ITGAL(2), ITGAM(7), ITGB2(5), SELE(8) 12373445 31 27 30 19 15 4 5 3 4 0 0.820 1.000 1.000 572 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), G6PD(3), GPI(2), H6PD(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(3), PRPS2(5), RBKS(1), RPE(1), RPIA(1), TAL1(1), TALDO1(2), TKT(2) 24255598 38 26 38 19 15 9 2 6 6 0 0.650 1.000 1.000 573 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(3), FYN(2), LRP8(1), RELN(25), VLDLR(2) 16639277 33 26 33 20 12 7 5 4 5 0 0.853 1.000 1.000 574 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(3), ESR2(6), PDE1A(3), PDE1B(2), PLCB1(4), PLCB2(7), PRL(1), TRH(1), VIP(2) 13203068 29 26 29 12 9 7 0 8 5 0 0.671 1.000 1.000 575 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), FPGT(1), GCK(2), GMDS(1), GMPPA(2), HK1(4), HK2(5), HK3(5), MPI(1), PFKFB1(6), PFKFB3(2), PFKFB4(1), PFKP(1), PMM1(1), SORD(1), TPI1(1) 28424515 42 25 42 17 18 10 2 7 5 0 0.352 1.000 1.000 576 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(2), B4GALT2(1), CHST1(2), CHST2(2), CHST4(2), CHST6(2), FUT8(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3) 14826172 28 25 28 12 12 4 5 4 3 0 0.610 1.000 1.000 577 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1) 27852536 39 25 39 14 10 6 7 11 5 0 0.505 1.000 1.000 578 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22(2), IL22RA1(1), JAK1(3), JAK2(5), JAK3(5), STAT1(4), STAT3(3), STAT5A(1), STAT5B(2), TYK2(10) 21916241 36 25 36 15 12 1 2 14 6 1 0.750 1.000 1.000 579 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), GOT1(2), GOT2(1), ME1(2), ME3(1), PGK1(3), PGK2(1), PKLR(4), RPE(1), RPIA(1), TKT(2), TKTL1(1), TKTL2(3), TPI1(1) 23926747 31 24 31 18 10 6 1 10 4 0 0.939 1.000 1.000 580 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(3), GOSR2(1), SNAP29(1), STX11(2), STX16(1), STX5(1), STX6(1), STX7(1), TSNARE1(4), USE1(3), VAMP4(1), VAMP5(3), VAMP7(3), VAMP8(1), VTI1A(2) 19867381 28 24 27 13 10 3 6 5 4 0 0.741 1.000 1.000 581 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(5), ARHGEF1(1), GNA13(1), GNB1(1), MYL2(2), MYLK(7), PLCB1(4), PPP1R12B(1), PRKCA(6), ROCK1(4) 24524358 32 24 31 18 10 3 4 10 4 1 0.930 1.000 1.000 582 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD8A(1), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9) 12760398 27 24 26 19 12 4 1 6 4 0 0.951 1.000 1.000 583 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9) 13391547 28 24 27 19 12 4 1 7 4 0 0.948 1.000 1.000 584 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(12), PRKCA(6), PTK2B(5) 7994338 26 23 24 13 9 4 3 6 3 1 0.735 1.000 1.000 585 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(5), CTH(2), DNMT1(3), DNMT3A(11), DNMT3B(4), MARS(7), MARS2(2), MAT1A(2), MTR(2) 20673971 38 23 38 16 9 8 2 11 6 2 0.601 1.000 1.000 586 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(3), JAK2(5), JAK3(5), PIAS1(2), PIAS3(3), PTPRU(3), REG1A(2), SOAT1(5) 16359794 29 23 29 11 5 3 3 10 8 0 0.709 1.000 1.000 587 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15(2), ALOX15B(1), ALOX5(2), ALOX5AP(1), DPEP1(2), GGT1(3), LTA4H(4), PLA2G6(3), PTGES(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(2) 17885423 30 22 30 13 10 8 2 4 6 0 0.577 1.000 1.000 588 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(2), CYP51A1(2), DHCR24(2), DHCR7(4), FDFT1(1), FDPS(3), GGCX(1), GGPS1(1), HSD17B7(2), IDI1(2), IDI2(1), LSS(1), MVD(4), MVK(1), NQO1(2), NSDHL(2), SQLE(1) 22923525 32 22 31 12 9 4 7 8 4 0 0.638 1.000 1.000 589 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), GOT1(2), GOT2(1), ME1(2), ME2(2), ME3(1), PGK1(3), PKLR(4), RPE(1), RPIA(1), TKT(2), TPI1(1) 21403975 28 21 28 14 8 6 1 10 3 0 0.846 1.000 1.000 590 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ECHS1(3), EHHADH(2), HADHA(3), SDS(1) 14437041 29 21 29 14 12 5 3 4 5 0 0.612 1.000 1.000 591 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(9), NFKB1(2), NFKBIA(3), RELA(1), TNFAIP3(2), TRAF3(1) 21553197 25 20 23 12 9 6 2 5 3 0 0.704 1.000 1.000 592 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(2), DRD1(1), DRD2(1), GRM1(7), PLCB1(4), PPP1CA(1), PPP1R1B(1), PPP2CA(4), PPP3CA(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1) 19058977 27 20 27 11 10 3 1 11 2 0 0.756 1.000 1.000 593 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3D(1), CD3E(2), CD3G(1), GZMB(3), HLA-A(1), ICAM1(3), ITGAL(2), ITGB2(5), PRF1(3) 10373523 22 19 22 13 11 2 2 2 5 0 0.783 1.000 1.000 594 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(4), ACAD9(1), ADH1A(3), ADH1B(4), ADH1C(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(3) 29663005 35 19 34 13 8 7 2 17 1 0 0.663 1.000 1.000 595 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(2), GPR161(3), GPR171(1), GPR18(2), GPR34(4), GPR45(4), GPR65(2), GPR68(1), GPR75(2) 11685644 23 18 23 11 7 3 4 4 5 0 0.639 1.000 1.000 596 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(3), CREB1(2), EP300(6), EPO(2), LDHA(1), NOS3(10), P4HB(1) 20239599 26 18 26 13 12 2 2 8 2 0 0.836 1.000 1.000 597 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(3), ACYP1(1), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(3), EHHADH(2), ESCO1(2), ESCO2(2), GCDH(1), HADHA(3), ITGB1BP3(1), PNPLA3(1), SH3GLB1(3), YOD1(1) 30823071 29 18 28 11 10 8 3 4 4 0 0.479 1.000 1.000 598 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(3), ATIC(1), DHFR(1), FTCD(4), GART(4), MTFMT(1), MTHFD1(3), MTHFD1L(1), MTHFR(7), MTHFS(2), MTR(2), SHMT1(2) 22492513 34 17 34 13 9 7 7 4 6 1 0.443 1.000 1.000 599 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), DHFR(1), HPRT1(1), IMPDH1(5), OAZ1(1), POLB(3), POLD1(3), POLG(1), PRPS2(5), RRM1(3), SRM(2) 14853006 29 17 29 12 12 5 5 5 2 0 0.537 1.000 1.000 600 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GLB1(2), GUSB(3), HEXA(1), HEXB(1), IDS(2), LCT(13), NAGLU(3) 17105985 25 16 25 11 10 3 4 4 4 0 0.674 1.000 1.000 601 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL2(2), IFNAR1(2), IFNAR2(3), IFNB1(2), MAPK8(2), NFKB1(2), RELA(1), TNFRSF11A(4), TNFSF11(1) 13172312 21 16 21 12 4 7 2 7 1 0 0.870 1.000 1.000 602 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(3), CRY1(3), CSNK1D(2), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(6), PER2(6), PER3(2) 20310019 25 15 24 13 6 7 1 9 2 0 0.898 1.000 1.000 603 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), HMOX1(1), IL10(1), IL10RB(1), IL1A(1), IL6(2), JAK1(3), STAT1(4), STAT3(3), STAT5A(1), TNF(1) 14452722 20 15 20 10 4 3 2 8 2 1 0.788 1.000 1.000 604 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(7) 19793532 26 14 26 15 9 3 2 11 1 0 0.953 1.000 1.000 605 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(2), ACOX3(3), ELOVL2(2), ELOVL6(1), FADS2(2), FASN(3), HADHA(3), PECR(2), SCD(1) 17075150 20 14 20 17 4 5 2 7 2 0 0.984 1.000 1.000 606 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(6), CLTA(1), COPA(2), GBF1(4), GPLD1(1), KDELR1(2), KDELR2(1), KDELR3(1) 19247103 19 13 19 10 4 6 3 3 3 0 0.799 1.000 1.000 607 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(3), ACAT2(1), ECHS1(3), EHHADH(2), HADHA(3), SDS(1) 9915205 14 12 14 10 2 4 2 2 4 0 0.921 1.000 1.000 608 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(2), GBGT1(2), GLA(2), HEXA(1), HEXB(1), ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), ST8SIA1(2) 12005633 17 12 17 11 6 2 1 5 3 0 0.977 1.000 1.000 609 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(2), B3GALT5(2), FUT2(2), GBGT1(2), GLA(2), HEXA(1), HEXB(1), ST3GAL1(3), ST3GAL2(1), ST8SIA1(2) 12742387 18 12 18 13 5 2 1 7 3 0 0.991 1.000 1.000 610 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(1), CNR2(3), DNMT1(3), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGER4(2), PTGFR(7), TBXA2R(1) 13305806 24 12 24 19 9 3 0 10 2 0 0.982 1.000 1.000 611 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(2), TAX1BP3(1), UBE2E3(1), UBE2G2(1), UBE2J2(1), UBE2L6(1), UBE2M(2), UBE3A(1) 12501412 12 12 12 12 6 1 2 1 2 0 0.987 1.000 1.000 612 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(2), HSD3B7(1) 5693548 6 6 6 5 3 0 0 3 0 0 0.958 1.000 1.000 613 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA3(2), LTB4R(1), P2RY1(1), P2RY2(3), P2RY6(2) 7080381 9 4 9 8 5 2 0 2 0 0 0.944 1.000 1.000 614 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 603256 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 1815426 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 2029362 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000