Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.114 0.324 -9999.0 0.0 -0.626 171.0 171.0 IHH -0.018 0.102 -9999.0 0.0 -0.584 14.0 14.0 SHH Np/Cholesterol/GAS1 -0.099 0.171 -9999.0 0.0 -0.367 181.0 181.0 LRPAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.099 0.17 0.364 181.0 -9999.0 0.0 181.0 SMO/beta Arrestin2 -0.042 0.188 -9999.0 0.0 -0.614 36.0 36.0 SMO -0.052 0.198 -9999.0 0.0 -0.648 37.0 37.0 AKT1 0.001 0.094 -9999.0 0.0 -0.362 6.0 6.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.009 0.064 -9999.0 0.0 -0.609 7.0 7.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.051 0.195 -9999.0 0.0 -0.636 37.0 37.0 STIL -0.105 0.231 -9999.0 0.0 -0.556 95.0 95.0 DHH N/PTCH2 -0.062 0.156 -9999.0 0.0 -0.446 93.0 93.0 DHH N/PTCH1 -0.084 0.218 -9999.0 0.0 -0.579 65.0 65.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.058 0.2 -9999.0 0.0 -0.603 79.0 79.0 PTHLH -0.119 0.359 -9999.0 0.0 -0.871 95.0 95.0 determination of left/right symmetry -0.051 0.195 -9999.0 0.0 -0.636 37.0 37.0 PIK3R1 0.012 0.043 -9999.0 0.0 -0.625 3.0 3.0 skeletal system development -0.117 0.353 -9999.0 0.0 -0.857 95.0 95.0 IHH N/Hhip -0.107 0.222 -9999.0 0.0 -0.498 159.0 159.0 DHH N/Hhip -0.148 0.23 -9999.0 0.0 -0.477 208.0 208.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.051 0.195 -9999.0 0.0 -0.636 37.0 37.0 pancreas development -0.125 0.26 -9999.0 0.0 -0.608 150.0 150.0 HHAT -0.002 0.103 -9999.0 0.0 -0.621 18.0 18.0 PI3K -0.002 0.03 -9999.0 0.0 -0.455 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.029 0.158 -9999.0 0.0 -0.59 49.0 49.0 somite specification -0.051 0.195 -9999.0 0.0 -0.636 37.0 37.0 SHH Np/Cholesterol/PTCH1 -0.102 0.226 -9999.0 0.0 -0.572 81.0 81.0 SHH Np/Cholesterol/PTCH2 -0.084 0.153 -9999.0 0.0 -0.348 161.0 161.0 SHH Np/Cholesterol/Megalin -0.189 0.223 -9999.0 0.0 -0.402 314.0 314.0 SHH -0.079 0.199 -9999.0 0.0 -0.449 148.0 148.0 catabolic process -0.055 0.206 -9999.0 0.0 -0.58 53.0 53.0 SMO/Vitamin D3 -0.092 0.227 -9999.0 0.0 -0.586 75.0 75.0 SHH Np/Cholesterol/Hhip -0.151 0.206 -9999.0 0.0 -0.39 259.0 259.0 LRP2 -0.195 0.295 -9999.0 0.0 -0.609 225.0 225.0 receptor-mediated endocytosis -0.192 0.227 -9999.0 0.0 -0.588 125.0 125.0 SHH Np/Cholesterol/BOC -0.079 0.15 -9999.0 0.0 -0.348 152.0 152.0 SHH Np/Cholesterol/CDO -0.092 0.164 -9999.0 0.0 -0.362 170.0 170.0 mesenchymal cell differentiation 0.15 0.205 0.387 259.0 -9999.0 0.0 259.0 mol:Vitamin D3 -0.099 0.227 -9999.0 0.0 -0.573 81.0 81.0 IHH N/PTCH2 -0.006 0.1 -9999.0 0.0 -0.438 30.0 30.0 CDON -0.015 0.134 -9999.0 0.0 -0.614 32.0 32.0 IHH N/PTCH1 -0.056 0.207 -9999.0 0.0 -0.584 53.0 53.0 Megalin/LRPAP1 -0.148 0.209 -9999.0 0.0 -0.441 225.0 225.0 PTCH2 0.0 0.096 -9999.0 0.0 -0.615 16.0 16.0 SHH Np/Cholesterol -0.077 0.148 -9999.0 0.0 -0.351 148.0 148.0 PTCH1 -0.055 0.206 -9999.0 0.0 -0.583 53.0 53.0 HHIP -0.125 0.261 -9999.0 0.0 -0.609 150.0 150.0