Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.019 0.111 -9999.0 0.0 -0.729 1.0 1.0 epithelial cell differentiation -0.062 0.123 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.008 0.068 -9999.0 0.0 -0.611 8.0 8.0 ENAH 0.018 0.112 -9999.0 0.0 -0.386 2.0 2.0 EGFR -0.112 0.251 -9999.0 0.0 -0.604 138.0 138.0 EPHA2 -0.017 0.135 -9999.0 0.0 -0.592 35.0 35.0 MYO6 -0.021 0.133 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.004 0.04 -9999.0 0.0 -0.369 8.0 8.0 AQP5 -0.189 0.205 -9999.0 0.0 -0.507 163.0 163.0 CTNND1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.021 0.131 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.035 0.148 -9999.0 0.0 -0.604 7.0 7.0 EGF -0.038 0.175 -9999.0 0.0 -0.612 57.0 57.0 NCKAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.077 0.144 -9999.0 0.0 -0.535 34.0 34.0 cortical microtubule organization -0.062 0.123 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.02 0.125 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.062 0.124 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.014 0.025 -9999.0 0.0 -0.625 1.0 1.0 ARF6/GDP -0.058 0.107 -9999.0 0.0 -0.486 11.0 11.0 ARF6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.018 0.074 -9999.0 0.0 -0.338 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.022 0.135 -9999.0 0.0 -0.421 12.0 12.0 PVRL2 0.014 0.025 -9999.0 0.0 -0.625 1.0 1.0 ZYX -0.029 0.139 -9999.0 0.0 -0.596 1.0 1.0 ARF6/GTP -0.017 0.066 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.112 0.251 -9999.0 0.0 -0.609 136.0 136.0 EGFR/EGFR/EGF/EGF -0.135 0.183 -9999.0 0.0 -0.589 53.0 53.0 RhoA/GDP -0.057 0.113 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.014 0.13 -9999.0 0.0 -0.578 1.0 1.0 IGF-1R heterotetramer 0.005 0.081 -9999.0 0.0 -0.62 11.0 11.0 GIT1 0.014 0.025 -9999.0 0.0 -0.625 1.0 1.0 IGF1R 0.005 0.081 -9999.0 0.0 -0.621 11.0 11.0 IGF1 -0.005 0.112 -9999.0 0.0 -0.613 22.0 22.0 DIAPH1 -0.003 0.065 -9999.0 0.0 -0.722 5.0 5.0 Wnt receptor signaling pathway 0.062 0.123 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.058 0.108 -9999.0 0.0 -0.486 11.0 11.0 CTNNA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.015 0.132 -9999.0 0.0 -0.597 1.0 1.0 EFNA1 0.012 0.041 -9999.0 0.0 -0.6 3.0 3.0 LPP -0.035 0.152 -9999.0 0.0 -0.557 11.0 11.0 Ephrin A1/EPHA2 -0.069 0.127 -9999.0 0.0 -0.561 10.0 10.0 SEC6/SEC8 -0.049 0.098 -9999.0 0.0 -0.543 2.0 2.0 MGAT3 -0.035 0.15 -9999.0 0.0 -0.617 7.0 7.0 HGF/MET -0.181 0.213 -9999.0 0.0 -0.609 91.0 91.0 HGF -0.088 0.23 -9999.0 0.0 -0.597 113.0 113.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.019 0.112 -9999.0 0.0 -0.738 1.0 1.0 actin cable formation 0.03 0.112 -9999.0 0.0 -0.374 5.0 5.0 KIAA1543 -0.077 0.195 -9999.0 0.0 -0.601 39.0 39.0 KIFC3 -0.022 0.134 -9999.0 0.0 -0.621 1.0 1.0 NCK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.043 0.155 -9999.0 0.0 -0.591 10.0 10.0 NCK1/GIT1 -0.001 0.018 -9999.0 0.0 -0.455 1.0 1.0 mol:GDP -0.062 0.123 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.021 0.133 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.022 0.133 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.008 0.07 -9999.0 0.0 -0.625 8.0 8.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.05 0.093 -9999.0 0.0 -0.416 11.0 11.0 adherens junction assembly -0.056 0.194 -9999.0 0.0 -0.577 40.0 40.0 IGF-1R heterotetramer/IGF1 -0.068 0.132 -9999.0 0.0 -0.614 12.0 12.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.001 0.025 -9999.0 0.0 -0.455 2.0 2.0 MET -0.164 0.281 -9999.0 0.0 -0.603 194.0 194.0 PLEKHA7 -0.026 0.142 -9999.0 0.0 -0.621 5.0 5.0 mol:GTP -0.018 0.073 -9999.0 0.0 -0.336 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.014 0.122 -9999.0 0.0 -0.513 2.0 2.0 cortical actin cytoskeleton stabilization -0.019 0.111 -9999.0 0.0 -0.729 1.0 1.0 regulation of cell-cell adhesion -0.014 0.13 -9999.0 0.0 -0.578 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.019 0.112 -9999.0 0.0 -0.738 1.0 1.0