E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.027 0.15 -9999.0 0.0 -0.435 75.0 75.0 KLHL20 0.016 0.073 0.156 2.0 -0.25 9.0 11.0 CYFIP2 0.022 0.041 -9999.0 0.0 -0.359 7.0 7.0 Rac1/GDP 0.001 0.099 0.269 3.0 -0.269 64.0 67.0 ENAH -0.028 0.151 -9999.0 0.0 -0.433 77.0 77.0 AP1M1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.015 -9999.0 0.0 -0.222 2.0 2.0 RAP1A 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.0 0.073 -9999.0 0.0 -0.4 3.0 3.0 ABI1/Sra1/Nap1 -0.015 0.038 -9999.0 0.0 -0.173 12.0 12.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.001 0.126 -9999.0 0.0 -0.28 89.0 89.0 RAPGEF1 -0.017 0.14 0.254 4.0 -0.387 73.0 77.0 CTNND1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.156 -9999.0 0.0 -0.447 77.0 77.0 CRK -0.026 0.142 -9999.0 0.0 -0.415 72.0 72.0 E-cadherin/gamma catenin/alpha catenin -0.002 0.115 -9999.0 0.0 -0.283 80.0 80.0 alphaE/beta7 Integrin 0.02 0.074 -9999.0 0.0 -0.239 45.0 45.0 IQGAP1 0.022 0.041 -9999.0 0.0 -0.359 7.0 7.0 NCKAP1 0.027 0.001 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.041 0.025 -9999.0 0.0 -0.25 1.0 1.0 DLG1 -0.028 0.15 -9999.0 0.0 -0.436 75.0 75.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.012 0.049 -9999.0 0.0 -0.274 3.0 3.0 MLLT4 0.025 0.02 -9999.0 0.0 -0.461 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.047 0.021 -9999.0 0.0 -0.25 1.0 1.0 PI3K -0.012 0.064 -9999.0 0.0 -0.366 3.0 3.0 ARF6 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.021 0.128 -9999.0 0.0 -0.259 134.0 134.0 TIAM1 0.025 0.019 -9999.0 0.0 -0.461 1.0 1.0 E-cadherin(dimer)/Ca2+ 0.014 0.1 -9999.0 0.0 -0.234 75.0 75.0 AKT1 0.003 0.045 0.107 19.0 -0.2 3.0 22.0 PIK3R1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.051 0.163 -9999.0 0.0 -0.36 132.0 132.0 RhoA/GDP 0.007 0.108 0.267 5.0 -0.269 69.0 74.0 actin cytoskeleton organization 0.019 0.063 0.165 23.0 -0.18 9.0 32.0 CDC42/GDP 0.005 0.107 0.267 5.0 -0.304 18.0 23.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.012 0.084 -9999.0 0.0 -0.232 79.0 79.0 ITGB7 0.002 0.097 -9999.0 0.0 -0.353 42.0 42.0 RAC1 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.016 0.107 -9999.0 0.0 -0.249 75.0 75.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.002 0.094 -9999.0 0.0 -0.234 76.0 76.0 mol:GDP -0.008 0.119 0.273 5.0 -0.311 71.0 76.0 CDC42/GTP/IQGAP1 0.03 0.027 -9999.0 0.0 -0.254 4.0 4.0 JUP 0.022 0.044 -9999.0 0.0 -0.393 7.0 7.0 p120 catenin/RhoA/GDP 0.011 0.111 0.275 3.0 -0.298 29.0 32.0 RAC1/GTP/IQGAP1 0.028 0.029 -9999.0 0.0 -0.224 6.0 6.0 PIP5K1C/AP1M1 0.038 0.017 -9999.0 0.0 -0.328 1.0 1.0 RHOA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.017 0.053 0.137 27.0 -0.17 17.0 44.0 NME1 0.025 0.02 -9999.0 0.0 -0.222 4.0 4.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.028 0.151 -9999.0 0.0 -0.434 77.0 77.0 regulation of cell-cell adhesion -0.005 0.062 -9999.0 0.0 -0.344 3.0 3.0 WASF2 0.008 0.028 -9999.0 0.0 -0.118 3.0 3.0 Rap1/GTP 0.005 0.089 0.243 2.0 -0.462 3.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.01 0.128 -9999.0 0.0 -0.269 92.0 92.0 CCND1 0.019 0.062 0.155 24.0 -0.21 17.0 41.0 VAV2 -0.014 0.171 -9999.0 0.0 -0.498 37.0 37.0 RAP1/GDP 0.008 0.098 0.268 3.0 -0.373 6.0 9.0 adherens junction assembly -0.026 0.147 -9999.0 0.0 -0.421 77.0 77.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.02 -9999.0 0.0 -0.461 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.003 0.12 -9999.0 0.0 -0.259 90.0 90.0 E-cadherin/beta catenin -0.031 0.111 -9999.0 0.0 -0.33 76.0 76.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.029 0.151 -9999.0 0.0 -0.439 74.0 74.0 PIK3CA 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.031 0.084 -9999.0 0.0 -0.384 12.0 12.0 E-cadherin/beta catenin/alpha catenin 0.001 0.111 -9999.0 0.0 -0.276 76.0 76.0 ITGAE 0.026 0.017 -9999.0 0.0 -0.222 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.029 0.16 -9999.0 0.0 -0.457 77.0 77.0