Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.066 0.224 -9999.0 0.0 -0.606 83.0 83.0 IHH -0.001 0.068 -9999.0 0.0 -0.227 15.0 15.0 SHH Np/Cholesterol/GAS1 -0.014 0.09 -9999.0 0.0 -0.256 64.0 64.0 LRPAP1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.014 0.09 0.254 64.0 -9999.0 0.0 64.0 SMO/beta Arrestin2 -0.019 0.136 -9999.0 0.0 -0.459 33.0 33.0 SMO -0.031 0.136 -9999.0 0.0 -0.483 33.0 33.0 AKT1 -0.005 0.109 -9999.0 0.0 -0.549 15.0 15.0 ARRB2 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.037 -9999.0 0.0 -0.342 6.0 6.0 ADRBK1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.03 0.134 -9999.0 0.0 -0.475 33.0 33.0 STIL -0.026 0.149 0.237 1.0 -0.351 63.0 64.0 DHH N/PTCH2 -0.0 0.096 -9999.0 0.0 -0.332 39.0 39.0 DHH N/PTCH1 -0.038 0.146 -9999.0 0.0 -0.338 87.0 87.0 PIK3CA 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.014 0.117 -9999.0 0.0 -0.321 75.0 75.0 PTHLH -0.079 0.272 -9999.0 0.0 -0.746 81.0 81.0 determination of left/right symmetry -0.03 0.134 -9999.0 0.0 -0.475 33.0 33.0 PIK3R1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.077 0.269 -9999.0 0.0 -0.737 81.0 81.0 IHH N/Hhip -0.045 0.144 -9999.0 0.0 -0.353 98.0 98.0 DHH N/Hhip -0.052 0.151 -9999.0 0.0 -0.35 112.0 112.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.03 0.134 -9999.0 0.0 -0.475 33.0 33.0 pancreas development -0.058 0.169 -9999.0 0.0 -0.359 144.0 144.0 HHAT 0.016 0.071 -9999.0 0.0 -0.445 15.0 15.0 PI3K 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.008 0.069 -9999.0 0.0 -0.238 46.0 46.0 somite specification -0.03 0.134 -9999.0 0.0 -0.475 33.0 33.0 SHH Np/Cholesterol/PTCH1 -0.047 0.134 -9999.0 0.0 -0.319 93.0 93.0 SHH Np/Cholesterol/PTCH2 -0.017 0.088 -9999.0 0.0 -0.257 66.0 66.0 SHH Np/Cholesterol/Megalin -0.067 0.129 -9999.0 0.0 -0.291 133.0 133.0 SHH -0.03 0.105 -9999.0 0.0 -0.251 107.0 107.0 catabolic process -0.031 0.143 -9999.0 0.0 -0.37 80.0 80.0 SMO/Vitamin D3 -0.044 0.14 -9999.0 0.0 -0.399 53.0 53.0 SHH Np/Cholesterol/Hhip -0.049 0.121 -9999.0 0.0 -0.279 118.0 118.0 LRP2 -0.103 0.196 -9999.0 0.0 -0.363 219.0 219.0 receptor-mediated endocytosis -0.079 0.166 -9999.0 0.0 -0.449 75.0 75.0 SHH Np/Cholesterol/BOC -0.014 0.086 -9999.0 0.0 -0.255 63.0 63.0 SHH Np/Cholesterol/CDO -0.02 0.096 -9999.0 0.0 -0.266 73.0 73.0 mesenchymal cell differentiation 0.049 0.12 0.278 118.0 -9999.0 0.0 118.0 mol:Vitamin D3 -0.02 0.158 -9999.0 0.0 -0.321 92.0 92.0 IHH N/PTCH2 0.017 0.062 -9999.0 0.0 -0.334 11.0 11.0 CDON 0.006 0.093 -9999.0 0.0 -0.4 31.0 31.0 IHH N/PTCH1 -0.025 0.147 -9999.0 0.0 -0.372 80.0 80.0 Megalin/LRPAP1 -0.057 0.147 -9999.0 0.0 -0.253 218.0 218.0 PTCH2 0.017 0.057 -9999.0 0.0 -0.382 12.0 12.0 SHH Np/Cholesterol -0.02 0.081 -9999.0 0.0 -0.254 60.0 60.0 PTCH1 -0.031 0.144 -9999.0 0.0 -0.371 80.0 80.0 HHIP -0.058 0.169 -9999.0 0.0 -0.36 144.0 144.0