Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.008 0.086 -9999.0 0.0 -0.228 79.0 79.0 epithelial cell differentiation 0.01 0.097 -9999.0 0.0 -0.232 75.0 75.0 CYFIP2 0.022 0.041 -9999.0 0.0 -0.359 7.0 7.0 ENAH -0.009 0.069 0.355 4.0 -0.291 1.0 5.0 EGFR -0.019 0.13 -9999.0 0.0 -0.457 53.0 53.0 EPHA2 0.009 0.064 -9999.0 0.0 -0.25 35.0 35.0 MYO6 -0.013 0.084 0.184 13.0 -0.221 74.0 87.0 CTNNB1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.045 0.033 -9999.0 0.0 -0.271 4.0 4.0 AQP5 -0.1 0.188 -9999.0 0.0 -0.457 126.0 126.0 CTNND1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.014 0.082 0.182 11.0 -0.219 74.0 85.0 regulation of calcium-dependent cell-cell adhesion -0.02 0.094 0.182 12.0 -0.235 88.0 100.0 EGF -0.006 0.114 -9999.0 0.0 -0.376 53.0 53.0 NCKAP1 0.027 0.001 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.026 0.115 -9999.0 0.0 -0.466 28.0 28.0 cortical microtubule organization 0.01 0.097 -9999.0 0.0 -0.232 75.0 75.0 GO:0000145 -0.022 0.075 0.172 11.0 -0.21 71.0 82.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.014 0.1 -9999.0 0.0 -0.234 75.0 75.0 MLLT4 0.025 0.02 -9999.0 0.0 -0.461 1.0 1.0 ARF6/GDP -0.027 0.068 -9999.0 0.0 -0.291 7.0 7.0 ARF6 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.049 0.051 -9999.0 0.0 -0.25 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.022 0.084 0.184 3.0 -0.324 21.0 24.0 PVRL2 0.023 0.021 -9999.0 0.0 -0.461 1.0 1.0 ZYX -0.013 0.076 0.184 7.0 -0.222 61.0 68.0 ARF6/GTP 0.054 0.051 -9999.0 0.0 -0.228 6.0 6.0 CDH1 -0.051 0.163 -9999.0 0.0 -0.36 132.0 132.0 EGFR/EGFR/EGF/EGF -0.028 0.12 -9999.0 0.0 -0.277 81.0 81.0 RhoA/GDP 0.013 0.093 -9999.0 0.0 -0.22 74.0 74.0 actin cytoskeleton organization -0.017 0.08 0.175 12.0 -0.221 68.0 80.0 IGF-1R heterotetramer 0.02 0.057 -9999.0 0.0 -0.461 9.0 9.0 GIT1 0.026 0.019 -9999.0 0.0 -0.461 1.0 1.0 IGF1R 0.02 0.057 -9999.0 0.0 -0.461 9.0 9.0 IGF1 0.013 0.077 -9999.0 0.0 -0.385 22.0 22.0 DIAPH1 -0.002 0.166 -9999.0 0.0 -0.547 19.0 19.0 Wnt receptor signaling pathway -0.01 0.097 0.232 75.0 -9999.0 0.0 75.0 RHOA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.028 0.069 -9999.0 0.0 -0.293 7.0 7.0 CTNNA1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.018 0.082 0.176 12.0 -0.226 68.0 80.0 EFNA1 0.025 0.024 -9999.0 0.0 -0.302 3.0 3.0 LPP -0.026 0.084 0.179 10.0 -0.273 15.0 25.0 Ephrin A1/EPHA2 -0.001 0.091 -9999.0 0.0 -0.225 55.0 55.0 SEC6/SEC8 -0.016 0.066 -9999.0 0.0 -0.403 2.0 2.0 MGAT3 -0.021 0.096 0.184 12.0 -0.238 88.0 100.0 HGF/MET -0.053 0.129 -9999.0 0.0 -0.269 130.0 130.0 HGF -0.02 0.112 -9999.0 0.0 -0.288 87.0 87.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.008 0.087 -9999.0 0.0 -0.23 79.0 79.0 actin cable formation 0.001 0.081 0.257 11.0 -0.291 8.0 19.0 KIAA1543 -0.025 0.081 0.173 8.0 -0.223 77.0 85.0 KIFC3 -0.015 0.084 0.184 8.0 -0.225 75.0 83.0 NCK1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.022 0.089 0.184 11.0 -0.232 74.0 85.0 NCK1/GIT1 0.039 0.015 -9999.0 0.0 -0.328 1.0 1.0 mol:GDP 0.01 0.097 -9999.0 0.0 -0.232 75.0 75.0 EXOC4 0.021 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.014 0.084 0.184 12.0 -0.222 75.0 87.0 PIP5K1C -0.014 0.083 0.184 11.0 -0.222 74.0 85.0 LIMA1 0.021 0.05 -9999.0 0.0 -0.461 7.0 7.0 ABI1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.008 0.078 0.373 4.0 -0.261 7.0 11.0 adherens junction assembly -0.011 0.088 0.288 7.0 -0.385 8.0 15.0 IGF-1R heterotetramer/IGF1 -0.002 0.105 -9999.0 0.0 -0.242 83.0 83.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.025 -9999.0 0.0 -0.328 2.0 2.0 MET -0.06 0.157 -9999.0 0.0 -0.328 151.0 151.0 PLEKHA7 -0.017 0.088 0.183 8.0 -0.234 77.0 85.0 mol:GTP 0.047 0.05 -9999.0 0.0 -0.248 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.03 0.112 0.325 21.0 -0.387 2.0 23.0 cortical actin cytoskeleton stabilization -0.008 0.086 -9999.0 0.0 -0.228 79.0 79.0 regulation of cell-cell adhesion -0.017 0.08 0.175 12.0 -0.221 68.0 80.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.008 0.087 -9999.0 0.0 -0.23 79.0 79.0