Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 KIRREL 0.019 0.013 -9999.0 0.0 -0.117 5.0 5.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 0.017 0.025 -9999.0 0.0 -0.219 5.0 5.0 ARRB2 0.013 0.039 -9999.0 0.0 -0.195 15.0 15.0 WASL 0.016 0.03 -9999.0 0.0 -0.291 5.0 5.0 Nephrin/NEPH1/podocin/CD2AP 0.037 0.043 -9999.0 0.0 -0.152 18.0 18.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.026 0.047 -9999.0 0.0 -0.197 19.0 19.0 FYN 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.045 0.02 -9999.0 0.0 -0.171 3.0 3.0 mol:DAG 0.046 0.02 -9999.0 0.0 -0.172 3.0 3.0 NPHS2 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.046 0.02 -9999.0 0.0 -0.172 3.0 3.0 regulation of endocytosis 0.027 0.045 -9999.0 0.0 -0.165 9.0 9.0 Nephrin/NEPH1/podocin/Cholesterol 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 establishment of cell polarity 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2 0.047 0.046 -9999.0 0.0 -0.159 21.0 21.0 Nephrin/NEPH1/beta Arrestin2 0.028 0.046 -9999.0 0.0 -0.166 9.0 9.0 NPHS1 0.02 0.006 -9999.0 0.0 -0.108 1.0 1.0 Nephrin/NEPH1/podocin 0.023 0.04 -9999.0 0.0 -0.127 2.0 2.0 TJP1 0.01 0.046 -9999.0 0.0 -0.193 22.0 22.0 NCK1 0.014 0.036 -9999.0 0.0 -0.188 14.0 14.0 NCK2 0.009 0.053 -9999.0 0.0 -0.28 17.0 17.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.047 0.02 -9999.0 0.0 -0.172 3.0 3.0 CD2AP 0.003 0.061 -9999.0 0.0 -0.194 39.0 39.0 Nephrin/NEPH1/podocin/GRB2 0.045 0.029 -9999.0 0.0 -0.175 8.0 8.0 GRB2 0.014 0.039 -9999.0 0.0 -0.255 10.0 10.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.021 0.016 -9999.0 0.0 -0.079 1.0 1.0 cytoskeleton organization 0.028 0.044 -9999.0 0.0 -0.224 12.0 12.0 Nephrin/NEPH1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/ZO-1 0.032 0.033 -9999.0 0.0 -0.175 10.0 10.0