Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.043 0.041 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.028 0.014 -9999.0 0.0 -0.094 1.0 1.0 SHH Np/Cholesterol/GAS1 0.012 0.039 -9999.0 0.0 -0.137 24.0 24.0 LRPAP1 0.013 0.043 -9999.0 0.0 -0.275 11.0 11.0 dorsoventral neural tube patterning -0.012 0.039 0.137 24.0 -9999.0 0.0 24.0 SMO/beta Arrestin2 0.053 0.031 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.047 0.027 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.012 0.152 -9999.0 0.0 -0.315 85.0 85.0 ARRB2 0.013 0.039 -9999.0 0.0 -0.195 15.0 15.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.018 0.014 -9999.0 0.0 -0.111 6.0 6.0 heart looping 0.047 0.027 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.035 0.032 -9999.0 0.0 -0.172 3.0 3.0 DHH N/PTCH2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.031 0.029 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA -0.011 0.085 -9999.0 0.0 -0.222 65.0 65.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.044 0.04 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.047 0.027 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.015 0.095 -9999.0 0.0 -0.268 62.0 62.0 skeletal system development 0.044 0.04 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip 0.019 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.047 0.027 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.018 0.014 -9999.0 0.0 -0.111 6.0 6.0 PI3K -0.015 0.092 -9999.0 0.0 -0.211 87.0 87.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.008 0.072 -9999.0 0.0 -0.164 78.0 78.0 somite specification 0.047 0.027 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.043 0.029 -9999.0 0.0 -0.162 1.0 1.0 SHH Np/Cholesterol/PTCH2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SHH 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.038 0.034 -9999.0 0.0 -0.165 3.0 3.0 SMO/Vitamin D3 0.051 0.029 -9999.0 0.0 -0.174 1.0 1.0 SHH Np/Cholesterol/Hhip 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 0.017 0.018 -9999.0 0.0 -0.111 10.0 10.0 receptor-mediated endocytosis 0.05 0.031 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation -0.013 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.045 0.03 -9999.0 0.0 -0.162 1.0 1.0 IHH N/PTCH2 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.045 0.037 -9999.0 0.0 -0.165 3.0 3.0 Megalin/LRPAP1 0.022 0.032 -9999.0 0.0 -0.19 10.0 10.0 PTCH2 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.016 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.038 0.034 -9999.0 0.0 -0.165 3.0 3.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0