E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.0 0.073 -9999.0 0.0 -0.305 21.0 21.0 KLHL20 0.051 0.12 0.25 90.0 -0.198 17.0 107.0 CYFIP2 0.033 0.014 -9999.0 0.0 0.0 78.0 78.0 Rac1/GDP -0.008 0.065 0.214 6.0 -0.273 8.0 14.0 ENAH 0.003 0.07 -9999.0 0.0 -0.322 17.0 17.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 0.001 65.0 -0.0 8.0 73.0 RAP1A 0.038 0.006 -9999.0 0.0 0.0 13.0 13.0 CTNNB1 0.038 0.007 -9999.0 0.0 0.0 18.0 18.0 CDC42/GTP -0.035 0.064 0.117 41.0 -0.233 13.0 54.0 ABI1/Sra1/Nap1 -0.02 0.034 -9999.0 0.0 -0.134 31.0 31.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.086 0.044 -9999.0 0.0 -0.125 8.0 8.0 RAPGEF1 -0.006 0.089 0.249 5.0 -0.302 15.0 20.0 CTNND1 0.036 0.01 -9999.0 0.0 0.0 37.0 37.0 regulation of calcium-dependent cell-cell adhesion 0.017 0.077 -9999.0 0.0 -0.303 22.0 22.0 CRK 0.0 0.089 0.214 8.0 -0.309 17.0 25.0 E-cadherin/gamma catenin/alpha catenin 0.065 0.036 -9999.0 0.0 -0.118 8.0 8.0 alphaE/beta7 Integrin 0.052 0.024 -9999.0 0.0 -0.128 6.0 6.0 IQGAP1 0.035 0.012 -9999.0 0.0 0.0 49.0 49.0 NCKAP1 0.039 0.003 -9999.0 0.0 0.0 3.0 3.0 Rap1/GTP/I-afadin 0.045 0.017 -9999.0 0.0 -0.09 1.0 1.0 DLG1 -0.001 0.075 -9999.0 0.0 -0.309 21.0 21.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.046 0.044 -9999.0 0.0 -0.177 27.0 27.0 MLLT4 0.036 0.011 -9999.0 0.0 0.0 45.0 45.0 ARF6/GTP/NME1/Tiam1 0.039 0.032 -9999.0 0.0 -0.091 22.0 22.0 PI3K -0.054 0.059 0.078 1.0 -0.228 27.0 28.0 ARF6 0.037 0.01 -9999.0 0.0 0.0 33.0 33.0 mol:Ca2+ 0.0 0.001 0.001 70.0 -0.0 15.0 85.0 E-cadherin/gamma catenin 0.051 0.019 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.035 0.012 -9999.0 0.0 0.0 50.0 50.0 E-cadherin(dimer)/Ca2+ 0.075 0.055 -9999.0 0.0 -0.134 22.0 22.0 AKT1 -0.024 0.066 0.161 21.0 -0.183 18.0 39.0 PIK3R1 0.034 0.013 -9999.0 0.0 0.0 69.0 69.0 CDH1 0.036 0.01 -9999.0 0.0 0.0 38.0 38.0 RhoA/GDP -0.007 0.088 0.223 12.0 -0.282 9.0 21.0 actin cytoskeleton organization 0.044 0.099 0.21 90.0 -0.146 17.0 107.0 CDC42/GDP -0.008 0.086 0.224 10.0 -0.281 8.0 18.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.006 0.051 -9999.0 0.0 -0.19 25.0 25.0 ITGB7 0.038 0.007 -9999.0 0.0 0.0 18.0 18.0 RAC1 0.023 0.019 -9999.0 0.0 0.0 209.0 209.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.081 0.059 -9999.0 0.0 -0.144 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.058 0.034 -9999.0 0.0 -0.104 10.0 10.0 mol:GDP -0.006 0.089 0.256 7.0 -0.311 9.0 16.0 CDC42/GTP/IQGAP1 0.039 0.04 -9999.0 0.0 -0.104 32.0 32.0 JUP 0.035 0.012 -9999.0 0.0 0.0 55.0 55.0 p120 catenin/RhoA/GDP -0.004 0.096 0.231 14.0 -0.273 10.0 24.0 RAC1/GTP/IQGAP1 0.023 0.039 -9999.0 0.0 -0.105 26.0 26.0 PIP5K1C/AP1M1 0.021 0.027 -9999.0 0.0 -0.112 19.0 19.0 RHOA 0.037 0.008 -9999.0 0.0 0.0 24.0 24.0 CDC42 0.037 0.009 -9999.0 0.0 0.0 27.0 27.0 CTNNA1 0.038 0.008 -9999.0 0.0 0.0 20.0 20.0 positive regulation of S phase of mitotic cell cycle 0.011 0.05 0.115 33.0 -0.111 26.0 59.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 26.0 26.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.002 0.073 -9999.0 0.0 -0.311 19.0 19.0 regulation of cell-cell adhesion -0.041 0.041 0.076 3.0 -0.182 20.0 23.0 WASF2 -0.011 0.019 -9999.0 0.0 -0.073 31.0 31.0 Rap1/GTP -0.028 0.076 0.146 50.0 -0.252 14.0 64.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.094 0.056 -9999.0 0.0 -0.13 12.0 12.0 CCND1 0.012 0.059 0.132 33.0 -0.132 29.0 62.0 VAV2 0.017 0.14 -9999.0 0.0 -0.547 18.0 18.0 RAP1/GDP -0.015 0.079 0.195 14.0 -0.253 13.0 27.0 adherens junction assembly 0.002 0.074 0.192 1.0 -0.3 21.0 22.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.018 -9999.0 0.0 0.0 150.0 150.0 PIP5K1C 0.034 0.013 -9999.0 0.0 0.0 60.0 60.0 regulation of heterotypic cell-cell adhesion 0.067 0.053 0.208 1.0 -0.137 14.0 15.0 E-cadherin/beta catenin 0.001 0.027 -9999.0 0.0 -0.129 10.0 10.0 mol:GTP 0.0 0.0 0.001 66.0 -0.0 26.0 92.0 SRC 0.002 0.073 0.207 7.0 -0.304 18.0 25.0 PIK3CA 0.033 0.014 -9999.0 0.0 0.0 79.0 79.0 Rac1/GTP -0.01 0.076 0.2 8.0 -0.285 24.0 32.0 E-cadherin/beta catenin/alpha catenin 0.067 0.037 -9999.0 0.0 -0.125 10.0 10.0 ITGAE 0.037 0.008 -9999.0 0.0 0.0 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.017 0.078 -9999.0 0.0 -0.308 22.0 22.0