Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.002 0.071 0.255 33.0 -9999.0 0.0 33.0 IHH 0.057 0.031 0.205 8.0 -9999.0 0.0 8.0 SHH Np/Cholesterol/GAS1 -0.021 0.023 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.038 0.007 -9999.0 0.0 0.0 18.0 18.0 dorsoventral neural tube patterning 0.021 0.023 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 0.104 0.083 0.322 24.0 -9999.0 0.0 24.0 SMO 0.023 0.05 0.281 5.0 -9999.0 0.0 5.0 AKT1 -0.01 0.128 -9999.0 0.0 -0.434 31.0 31.0 ARRB2 0.037 0.009 -9999.0 0.0 0.0 28.0 28.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.038 0.006 -9999.0 0.0 0.0 13.0 13.0 heart looping 0.023 0.051 0.275 6.0 -9999.0 0.0 6.0 STIL 0.057 0.116 0.303 39.0 -9999.0 0.0 39.0 DHH N/PTCH2 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.026 0.031 0.175 20.0 -9999.0 0.0 20.0 PIK3CA 0.033 0.014 -9999.0 0.0 0.0 79.0 79.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.042 0.081 0.311 23.0 -9999.0 0.0 23.0 determination of left/right symmetry 0.023 0.051 0.275 6.0 -9999.0 0.0 6.0 PIK3R1 0.034 0.013 -9999.0 0.0 0.0 69.0 69.0 skeletal system development 0.041 0.081 0.31 23.0 -9999.0 0.0 23.0 IHH N/Hhip 0.037 0.019 0.125 8.0 -9999.0 0.0 8.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.023 0.051 0.275 6.0 -9999.0 0.0 6.0 pancreas development -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.037 0.008 -9999.0 0.0 0.0 21.0 21.0 PI3K 0.023 0.07 -9999.0 0.0 -0.14 72.0 72.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.032 0.015 -9999.0 0.0 0.0 90.0 90.0 somite specification 0.023 0.051 0.275 6.0 -9999.0 0.0 6.0 SHH Np/Cholesterol/PTCH1 -0.009 0.04 0.163 22.0 -9999.0 0.0 22.0 SHH Np/Cholesterol/PTCH2 -0.021 0.019 0.103 1.0 -9999.0 0.0 1.0 SHH Np/Cholesterol/Megalin -0.02 0.019 0.103 1.0 -9999.0 0.0 1.0 SHH -0.02 0.019 0.117 1.0 -9999.0 0.0 1.0 catabolic process 0.039 0.05 0.212 38.0 -9999.0 0.0 38.0 SMO/Vitamin D3 0.004 0.065 0.288 16.0 -9999.0 0.0 16.0 SHH Np/Cholesterol/Hhip -0.014 0.012 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 0.038 0.006 -9999.0 0.0 0.0 13.0 13.0 receptor-mediated endocytosis 0.006 0.052 0.244 6.0 -9999.0 0.0 6.0 SHH Np/Cholesterol/BOC -0.014 0.012 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO -0.021 0.019 0.103 1.0 -9999.0 0.0 1.0 mesenchymal cell differentiation 0.014 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.069 0.12 0.207 201.0 -9999.0 0.0 201.0 IHH N/PTCH2 0.066 0.021 0.166 5.0 -9999.0 0.0 5.0 CDON 0.038 0.005 -9999.0 0.0 0.0 9.0 9.0 IHH N/PTCH1 0.054 0.044 0.246 21.0 -9999.0 0.0 21.0 Megalin/LRPAP1 0.052 0.028 -9999.0 0.0 -0.128 10.0 10.0 PTCH2 0.038 0.006 -9999.0 0.0 0.0 11.0 11.0 SHH Np/Cholesterol 0.06 0.105 0.192 196.0 -9999.0 0.0 196.0 PTCH1 0.039 0.05 0.213 38.0 -9999.0 0.0 38.0 HHIP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0