Clinical Features	Time to Death		YEARS_TO_BIRTH		NEOPLASM_DISEASESTAGE		PATHOLOGY_T_STAGE		PATHOLOGY_N_STAGE		GENDER		HISTOLOGICAL_TYPE		RADIATIONS_RADIATION_REGIMENINDICATION		NUMBER_PACK_YEARS_SMOKED		YEAR_OF_TOBACCO_SMOKING_ONSET		NUMBER_OF_LYMPH_NODES		RACE		ETHNICITY	
	nMutated (%)	nWild-Type	logrank test_P	logrank test_Q	Wilcoxon-test_P	Wilcoxon-test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Wilcoxon-test_P	Wilcoxon-test_Q	Wilcoxon-test_P	Wilcoxon-test_Q	Wilcoxon-test_P	Wilcoxon-test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	356 (70%)	150	0.0049315	0.31	0.26389	0.999	0.51963	1	0.02755	0.619	0.65947	1	0.82802	1	0.00331	0.296	0.36142	1	0.083379	0.797	0.86139	1	0.64317	1	0.60975	1	0.12317	0.888
CDKN2A	110 (22%)	396	0.71814	1	0.14286	0.888	0.31717	1	0.69152	1	0.6636	1	0.90396	1	0.49675	1	0.14862	0.888	0.39184	1	0.48723	1	0.43019	1	0.57252	1	0.46905	1
PIK3CA	94 (19%)	412	0.54814	1	0.69144	1	0.45931	1	0.30588	1	0.19725	0.941	0.040802	0.627	0.47827	1	0.64395	1	0.83858	1	0.67018	1	0.3462	1	0.03265	0.627	1	1
NSD1	63 (12%)	443	0.030799	0.627	0.03901	0.627	0.11454	0.888	0.57112	1	0.03805	0.627	0.069565	0.732	1	1	0.14515	0.888	0.097659	0.854	0.60046	1	0.00031051	0.0646	0.67628	1	0.21696	0.955
CASP8	54 (11%)	452	0.026377	0.61	6.4627e-09	5.38e-06	0.88861	1	0.39851	1	0.066709	0.73	0.00028626	0.0646	1	1	0.1729	0.924	0.11149	0.888	0.016214	0.465	0.017058	0.473	0.7242	1	0.50594	1
HRAS	28 (6%)	478	0.54604	1	0.38464	1	0.44977	1	0.93913	1	0.13341	0.888	0.079506	0.778	1	1	0.065565	0.727	0.97136	1	0.62299	1	0.11879	0.888	0.56435	1	0.38682	1
TGFBR2	23 (5%)	483	0.70416	1	0.059018	0.707	0.86052	1	0.7178	1	0.54887	1	1	1	1	1	0.021087	0.528	0.34377	1	0.094822	0.839	0.40689	1	0.58903	1	1	1
FAT1	113 (22%)	393	0.66537	1	1.4343e-06	0.000597	0.78719	1	0.04063	0.627	0.32774	1	0.011782	0.392	1	1	1	1	0.14447	0.888	0.021557	0.528	0.35039	1	0.59842	1	0.45515	1
NOTCH1	86 (17%)	420	0.29819	1	0.0079989	0.343	0.9467	1	0.42574	1	0.48694	1	0.062867	0.707	0.6754	1	0.87306	1	0.12201	0.888	0.21535	0.955	0.19798	0.941	0.92684	1	0.17729	0.924
EPHA2	23 (5%)	483	0.254	0.999	0.12594	0.888	0.82698	1	0.66876	1	0.16798	0.924	0.47359	1	1	1	1	1	0.055915	0.707	0.15181	0.888	0.93962	1	0.39926	1	1	1
HLA-B	24 (5%)	482	0.77774	1	0.1968	0.941	0.73608	1	0.36312	1	0.03851	0.627	0.15675	0.888	0.3254	1	0.021045	0.528	0.24472	0.999	0.15171	0.888	0.30419	1	0.51732	1	0.61422	1
RAC1	15 (3%)	491	0.47467	1	0.001189	0.165	0.22145	0.968	0.18798	0.937	0.40443	1	0.0073982	0.342	1	1	1	1	0.73811	1	0.0052103	0.31	0.18957	0.937	0.3068	1	1	1
NFE2L2	26 (5%)	480	0.12572	0.888	0.0039074	0.296	0.78939	1	0.81267	1	0.59395	1	0.11161	0.888	1	1	0.28457	1	0.67424	1	0.21596	0.955	0.34303	1	0.30814	1	0.32922	1
ZNF750	19 (4%)	487	0.93943	1	0.37154	1	0.30135	1	0.7228	1	0.55718	1	0.30407	1	1	1	0.75218	1	0.47041	1	0.52905	1	0.071767	0.737	0.40741	1	0.61441	1
PTEN	14 (3%)	492	0.18421	0.937	0.31844	1	0.93554	1	0.30063	1	0.49369	1	1	1	1	1	0.4844	1	0.4188	1	0.16739	0.924	0.51609	1	0.73593	1	1	1
HLA-A	22 (4%)	484	0.96654	1	0.09006	0.821	0.90134	1	0.089409	0.821	0.30927	1	1	1	1	1	0.77038	1	0.20937	0.947	0.014419	0.444	0.74195	1	0.81313	1	0.61422	1
RB1	17 (3%)	489	0.14352	0.888	0.55975	1	0.14679	0.888	0.24673	0.999	0.73607	1	0.0095235	0.345	1	1	1	1	0.66064	1	0.31457	1	0.33044	1	0.35777	1	1	1
MAPK1	9 (2%)	497	0.26146	0.999	0.94954	1	0.86775	1	0.4291	1	0.65191	1	0.71121	1	1	1	0.36712	1	NA	NA	0.42734	1	0.88587	1	0.23483	0.987	1	1
KDM6A	17 (3%)	489	0.39929	1	0.05463	0.707	0.41811	1	0.25575	0.999	0.84815	1	1	1	1	1	0.33031	1	0.15092	0.888	0.20283	0.947	0.90941	1	0.28529	1	1	1
EP300	39 (8%)	467	0.37714	1	0.73054	1	0.90898	1	0.72281	1	0.5127	1	0.45487	1	1	1	0.65602	1	0.25846	0.999	0.6922	1	0.8228	1	0.74074	1	0.43491	1
RASA1	17 (3%)	489	0.99143	1	0.78126	1	0.67089	1	0.43598	1	0.95725	1	0.42306	1	1	1	0.044168	0.627	0.40665	1	0.9436	1	0.75746	1	1	1	0.22692	0.973
NAP1L2	7 (1%)	499	0.69833	1	0.90878	1	0.258	0.999	0.66848	1	0.14815	0.888	1	1	0.10508	0.883	1	1	0.58056	1	0.86267	1	0.46137	1	0.4701	1	0.0024019	0.25
CREBBP	35 (7%)	471	0.24662	0.999	0.033762	0.627	0.68923	1	0.7299	1	0.88616	1	0.56165	1	0.43776	1	0.2422	0.998	0.71211	1	0.048253	0.668	0.64244	1	0.16132	0.907	1	1
CTCF	16 (3%)	490	0.07041	0.732	0.0010287	0.165	0.14068	0.888	1	1	0.45048	1	0.048956	0.668	1	1	0.31317	1	0.70947	1	0.043777	0.627	0.32013	1	0.42931	1	1	1
KEAP1	22 (4%)	484	0.99395	1	0.09857	0.854	0.10978	0.888	0.0088399	0.343	0.38366	1	0.15047	0.888	0.04305	0.627	0.069881	0.732	0.093722	0.838	0.36546	1	0.82655	1	0.48043	1	0.61422	1
RHOA	10 (2%)	496	0.31785	1	0.39588	1	1	1	0.41587	1	0.03271	0.627	0.47317	1	0.14806	0.888	0.37976	1	0.70683	1	0.63339	1	0.31978	1	1	1	1	1
FBXW7	33 (7%)	473	0.34381	1	0.0066018	0.331	0.70177	1	0.40355	1	0.3596	1	0.15586	0.888	1	1	0.63055	1	0.31547	1	0.85657	1	0.18734	0.937	0.88155	1	0.6613	1
TIGD4	7 (1%)	499	0.3119	1	0.17695	0.924	0.26788	0.999	0.77932	1	0.18966	0.937	0.67966	1	1	1	0.60573	1	0.50597	1	0.45435	1	0.17761	0.924	0.5266	1	1	1
KRT5	11 (2%)	495	0.61789	1	0.26226	0.999	0.053909	0.707	0.2412	0.998	0.73762	1	0.50387	1	1	1	0.69856	1	0.011503	0.392	0.0083046	0.343	0.53189	1	0.26113	0.999	1	1
SMAD4	14 (3%)	492	0.4848	1	0.42039	1	0.68386	1	1	1	0.68324	1	0.76707	1	1	1	0.71137	1	0.42308	1	0.19177	0.939	0.88399	1	1	1	1	1
ASXL1	16 (3%)	490	0.23873	0.998	0.84225	1	0.51303	1	0.17145	0.924	0.13845	0.888	0.77719	1	1	1	1	1	0.9363	1	0.71714	1	0.81369	1	0.57742	1	1	1
CES2	11 (2%)	495	0.99111	1	0.84293	1	0.61715	1	0.53318	1	1	1	0.50387	1	1	1	1	1	0.57851	1	0.63016	1	0.81974	1	0.060479	0.707	1	1
IRS4	17 (3%)	489	0.93753	1	0.93073	1	0.70961	1	0.76111	1	0.42149	1	0.26607	0.999	1	1	1	1	0.83593	1	0.98558	1	0.15344	0.888	0.54617	1	0.18676	0.937
ARID2	20 (4%)	486	0.25032	0.999	0.86857	1	0.86789	1	0.47773	1	0.77149	1	0.44829	1	1	1	0.22312	0.968	0.20924	0.947	0.32562	1	0.20769	0.947	0.22379	0.968	0.26779	0.999
CBWD1	5 (1%)	501	0.0090664	0.343	0.20136	0.947	1	1	0.91827	1	0.68765	1	0.3294	1	1	1	0.59332	1	NA	NA	NA	NA	0.31154	1	1	1	1	1
RGL4	7 (1%)	499	0.12267	0.888	0.55356	1	0.0067699	0.331	0.01942	0.521	0.33096	1	0.39956	1	1	1	0.60573	1	0.32534	1	0.38918	1	0.035754	0.627	0.5233	1	1	1
HUWE1	45 (9%)	461	0.20585	0.947	0.34568	1	0.91308	1	0.55887	1	0.44137	1	0.023691	0.563	1	1	0.4016	1	0.37419	1	0.46305	1	0.56786	1	0.076479	0.767	0.27111	1
HNRNPL	11 (2%)	495	0.59233	1	0.039233	0.627	0.27838	1	0.42664	1	0.10202	0.875	0.18377	0.937	1	1	0.69856	1	0.54469	1	0.65729	1	0.21655	0.955	1	1	1	1
ITGB1	14 (3%)	492	0.57453	1	0.11996	0.888	0.13398	0.888	0.14351	0.888	0.38252	1	1	1	1	1	0.4844	1	0.70006	1	0.97252	1	0.56225	1	1	1	0.5399	1
B2M	7 (1%)	499	0.60489	1	0.93359	1	0.74366	1	1	1	0.43608	1	1	1	1	1	0.60573	1	0.087046	0.821	0.72938	1	0.033803	0.627	1	1	1	1
LRRC37B	16 (3%)	490	0.47065	1	0.91349	1	0.96925	1	0.88091	1	0.69908	1	0.39544	1	0.23055	0.981	1	1	0.30566	1	0.58704	1	0.93323	1	1	1	1	1
PPFIA4	14 (3%)	492	0.39665	1	0.8587	1	0.47221	1	0.51898	1	0.04056	0.627	0.2246	0.968	1	1	0.71137	1	0.42792	1	0.69636	1	0.0043	0.298	1	1	1	1
PIK3R1	9 (2%)	497	0.044481	0.627	0.80017	1	0.5213	1	0.80146	1	0.15694	0.888	0.45549	1	1	1	1	1	0.77457	1	0.88815	1	0.17761	0.924	1	1	1	1
VPS33B	7 (1%)	499	0.91432	1	0.11696	0.888	0.17318	0.924	0.88085	1	0.080769	0.781	0.39956	1	0.10371	0.88	1	1	0.65146	1	0.42092	1	0.68799	1	0.52321	1	1	1
C8ORF31	4 (1%)	502	0.65095	1	0.19538	0.941	0.87137	1	0.59749	1	NA	NA	1	1	1	1	0.51276	1	0.946	1	0.63653	1	NA	NA	1	1	1	1
NCOR1	18 (4%)	488	0.97479	1	0.27627	1	0.75162	1	0.53149	1	0.73685	1	0.59372	1	1	1	0.33155	1	0.70159	1	0.42577	1	0.36187	1	0.77981	1	0.24731	0.999
SEH1L	4 (1%)	502	0.91969	1	0.58736	1	0.7444	1	1	1	0.19039	0.937	1	1	1	1	1	1	NA	NA	NA	NA	0.035754	0.627	0.12958	0.888	1	1
CUL3	14 (3%)	492	0.45721	1	0.26189	0.999	0.16939	0.924	0.04219	0.627	0.61828	1	0.36904	1	1	1	0.062401	0.707	0.71325	1	0.17105	0.924	0.21161	0.952	0.17994	0.93	1	1
NOTCH2	19 (4%)	487	0.94642	1	0.10943	0.888	0.25935	0.999	0.75129	1	0.56506	1	0.0063199	0.331	1	1	0.53243	1	0.30347	1	0.15037	0.888	0.4248	1	1	1	0.61441	1
YTHDF1	6 (1%)	500	0.031001	0.627	0.4754	1	0.90416	1	0.34845	1	0.88041	1	0.66839	1	0.090809	0.821	0.25645	0.999	0.33766	1	0.68886	1	0.70435	1	1	1	1	1
FOSL2	10 (2%)	496	0.0038353	0.296	0.87756	1	0.72948	1	0.95867	1	0.8811	1	0.14707	0.888	1	1	0.67168	1	0.64642	1	0.96892	1	0.061938	0.707	1	1	1	1
MYH9	22 (4%)	484	0.61154	1	0.60686	1	0.85998	1	0.96355	1	0.75911	1	0.46401	1	0.30134	1	1	1	0.43809	1	0.3689	1	0.61002	1	0.52875	1	0.26779	0.999
TP63	12 (2%)	494	0.13732	0.888	0.79728	1	0.33031	1	0.57615	1	0.52616	1	0.74392	1	1	1	0.11712	0.888	0.60622	1	0.65224	1	0.19795	0.941	1	1	1	1
DYSF	21 (4%)	485	0.77057	1	0.054762	0.707	0.97254	1	0.69246	1	0.11472	0.888	1	1	1	1	0.76252	1	0.057081	0.707	0.11432	0.888	0.078273	0.775	1	1	0.61572	1
TMEM2	17 (3%)	489	0.79161	1	0.85402	1	0.069979	0.732	0.19965	0.944	0.27813	1	0.7889	1	1	1	0.044168	0.627	0.97842	1	0.90904	1	0.50932	1	1	1	0.5399	1
PTPN14	14 (3%)	492	0.12347	0.888	0.97633	1	0.36747	1	0.56554	1	0.25957	0.999	1	1	1	1	0.062401	0.707	0.40399	1	0.51365	1	0.40793	1	0.073889	0.75	0.5399	1
RBM10	4 (1%)	502	0.41539	1	0.83673	1	1	1	0.53513	1	0.6896	1	1	1	1	1	0.12761	0.888	NA	NA	NA	NA	0.525	1	1	1	0.01528	0.454
IRF2	7 (1%)	499	0.29807	1	0.60522	1	0.78072	1	0.46488	1	0.67329	1	1	1	1	1	1	1	0.15481	0.888	0.058728	0.707	0.83076	1	1	1	1	1
AMPD1	6 (1%)	500	0.36746	1	0.99776	1	0.79671	1	0.91878	1	1	1	0.66839	1	1	1	1	1	0.23122	0.981	0.17748	0.924	0.91001	1	1	1	1	1
ZMYM1	9 (2%)	497	0.062362	0.707	0.78155	1	0.66363	1	0.78227	1	0.52852	1	0.71121	1	1	1	0.64613	1	0.20598	0.947	0.89142	1	0.44237	1	1	1	1	1
LCP1	15 (3%)	491	0.73692	1	0.65909	1	0.27498	1	0.089859	0.821	1	1	1	1	1	1	0.2855	1	0.66668	1	0.39288	1	0.62797	1	0.72662	1	0.56513	1
SLC9A6	5 (1%)	501	0.0016648	0.198	0.79617	1	0.32164	1	0.46385	1	0.12874	0.888	0.1302	0.888	1	1	0.59332	1	0.86133	1	NA	NA	0.14193	0.888	1	1	1	1
CCNG2	3 (1%)	503	0.66779	1	0.2346	0.987	0.4805	1	1	1	0.41615	1	1	1	1	1	1	1	0.13902	0.888	0.040465	0.627	NA	NA	0.01339	0.428	1	1
TACR2	4 (1%)	502	0.209	0.947	0.67144	1	0.74511	1	1	1	0.41887	1	0.5792	1	1	1	0.51276	1	0.99431	1	NA	NA	0.24212	0.998	1	1	1	1