Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.272 0.231 -9999.0 0.0 -0.944 14.0 14.0 IHH -0.054 0.074 -9999.0 0.0 -0.764 3.0 3.0 SHH Np/Cholesterol/GAS1 -0.043 0.137 -9999.0 0.0 -0.48 46.0 46.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.042 0.136 0.477 46.0 -9999.0 0.0 46.0 SMO/beta Arrestin2 -0.141 0.154 -9999.0 0.0 -0.593 25.0 25.0 SMO -0.156 0.163 -9999.0 0.0 -0.631 25.0 25.0 AKT1 -0.059 0.083 -9999.0 0.0 -0.605 2.0 2.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.04 0.171 -9999.0 0.0 -0.582 47.0 47.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.154 0.16 -9999.0 0.0 -0.62 25.0 25.0 STIL -0.132 0.166 -9999.0 0.0 -0.628 32.0 32.0 DHH N/PTCH2 -0.015 0.087 -9999.0 0.0 -0.51 15.0 15.0 DHH N/PTCH1 -0.135 0.142 -9999.0 0.0 -0.771 9.0 9.0 PIK3CA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.009 0.051 -9999.0 0.0 -0.807 2.0 2.0 PTHLH -0.448 0.333 -9999.0 0.0 -0.652 369.0 369.0 determination of left/right symmetry -0.154 0.16 -9999.0 0.0 -0.62 25.0 25.0 PIK3R1 0.011 0.037 -9999.0 0.0 -0.577 2.0 2.0 skeletal system development -0.444 0.33 -9999.0 0.0 -0.646 369.0 369.0 IHH N/Hhip -0.054 0.166 -9999.0 0.0 -0.672 34.0 34.0 DHH N/Hhip -0.039 0.15 -9999.0 0.0 -0.612 33.0 33.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.154 0.16 -9999.0 0.0 -0.62 25.0 25.0 pancreas development -0.037 0.192 -9999.0 0.0 -0.798 31.0 31.0 HHAT 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.002 0.026 -9999.0 0.0 -0.415 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.002 0.091 -9999.0 0.0 -0.721 8.0 8.0 somite specification -0.154 0.16 -9999.0 0.0 -0.62 25.0 25.0 SHH Np/Cholesterol/PTCH1 -0.145 0.174 -9999.0 0.0 -0.598 44.0 44.0 SHH Np/Cholesterol/PTCH2 -0.045 0.148 -9999.0 0.0 -0.496 47.0 47.0 SHH Np/Cholesterol/Megalin -0.061 0.18 -9999.0 0.0 -0.549 58.0 58.0 SHH -0.028 0.166 -9999.0 0.0 -0.619 38.0 38.0 catabolic process -0.161 0.155 -9999.0 0.0 -0.727 11.0 11.0 SMO/Vitamin D3 -0.152 0.176 -9999.0 0.0 -0.644 33.0 33.0 SHH Np/Cholesterol/Hhip -0.065 0.185 -9999.0 0.0 -0.554 60.0 60.0 LRP2 -0.031 0.182 -9999.0 0.0 -0.807 27.0 27.0 receptor-mediated endocytosis -0.168 0.166 -9999.0 0.0 -0.609 47.0 47.0 SHH Np/Cholesterol/BOC -0.065 0.153 -9999.0 0.0 -0.499 39.0 39.0 SHH Np/Cholesterol/CDO -0.044 0.135 -9999.0 0.0 -0.491 38.0 38.0 mesenchymal cell differentiation 0.064 0.183 0.549 60.0 -9999.0 0.0 60.0 mol:Vitamin D3 -0.144 0.174 -9999.0 0.0 -0.597 44.0 44.0 IHH N/PTCH2 -0.025 0.099 -9999.0 0.0 -0.556 16.0 16.0 CDON -0.001 0.092 -9999.0 0.0 -0.577 13.0 13.0 IHH N/PTCH1 -0.162 0.157 -9999.0 0.0 -0.734 11.0 11.0 Megalin/LRPAP1 -0.032 0.137 -9999.0 0.0 -0.618 27.0 27.0 PTCH2 -0.004 0.107 -9999.0 0.0 -0.666 13.0 13.0 SHH Np/Cholesterol -0.033 0.131 -9999.0 0.0 -0.5 38.0 38.0 PTCH1 -0.161 0.156 -9999.0 0.0 -0.732 11.0 11.0 HHIP -0.038 0.192 -9999.0 0.0 -0.8 31.0 31.0