Clinical Features Time to Death YEARS_TO_BIRTH NEOPLASM_DISEASESTAGE PATHOLOGY_T_STAGE PATHOLOGY_N_STAGE PATHOLOGY_M_STAGE GENDER KARNOFSKY_PERFORMANCE_SCORE HISTOLOGICAL_TYPE NUMBER_PACK_YEARS_SMOKED YEAR_OF_TOBACCO_SMOKING_ONSET RACE ETHNICITY nMutated (%) nWild-Type logrank test_P logrank test_Q Wilcoxon-test_P Wilcoxon-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Wilcoxon-test_P Wilcoxon-test_Q Fisher's exact test_P Fisher's exact test_Q Wilcoxon-test_P Wilcoxon-test_Q Wilcoxon-test_P Wilcoxon-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q TP53 38 (6%) 630 0.36934 1 0.20237 1 0.00318 0.103 0.00325 0.103 0.091149 0.9 0.56949 1 0.4861 1 0.2803 1 9.9999e-06 0.00158 0.3861 1 0.97403 1 0.22962 1 1 1 PBRM1 146 (22%) 522 0.29033 1 0.0066268 0.18 0.76448 1 0.36997 1 0.02216 0.376 0.49072 1 0.62202 1 0.98096 1 9.9999e-06 0.00158 NA NA NA NA 0.0069499 0.183 0.2665 1 PTEN 28 (4%) 640 0.65134 1 0.66514 1 0.27359 1 0.4747 1 0.16597 1 0.23019 1 0.68462 1 0.2803 1 0.12029 0.904 1 1 0.84087 1 0.54851 1 1 1 BAP1 49 (7%) 619 8.6091e-05 0.00681 0.64923 1 3e-05 0.00316 7.9999e-05 0.00681 0.7759 1 0.0043551 0.129 0.012418 0.262 NA NA 2e-04 0.0146 NA NA NA NA 0.66825 1 0.73454 1 SETD2 58 (9%) 610 0.0093356 0.233 0.030875 0.48 0.055229 0.68 0.065969 0.763 0.42094 1 0.21609 1 0.31153 1 0.62807 1 0.068439 0.777 NA NA NA NA 0.93924 1 0.50149 1 KDM5C 30 (4%) 638 0.016183 0.301 0.0096461 0.235 0.83112 1 0.81619 1 0.7846 1 1 1 0.0028598 0.101 NA NA 0.01289 0.266 NA NA NA NA 0.86769 1 0.38484 1 NEFH 15 (2%) 653 0.50769 1 0.41923 1 0.27437 1 0.23905 1 NA NA 1 1 0.59636 1 0.2803 1 0.00141 0.0669 0.5195 1 NA NA 0.10629 0.904 1 1 VHL 174 (26%) 494 0.1183 0.904 0.18226 1 0.35774 1 0.2638 1 0.068889 0.777 0.69514 1 0.35314 1 0.795 1 9.9999e-06 0.00158 NA NA NA NA 9.9999e-06 0.00158 0.68083 1 NF2 16 (2%) 652 0.10868 0.904 0.22769 1 0.03 0.474 0.11768 0.904 4e-05 0.0038 0.04115 0.571 0.79354 1 NA NA 0.00254 0.0927 NA NA NA NA 0.056709 0.681 0.21727 1 HNRNPM 12 (2%) 656 0.32227 1 0.46517 1 0.4427 1 0.060059 0.704 0.35094 1 0.60099 1 0.76 1 0.83644 1 2e-05 0.00237 NA NA NA NA 0.21668 1 1 1 MET 19 (3%) 649 0.782 1 0.84529 1 0.45806 1 0.92589 1 0.10242 0.9 1 1 1 1 NA NA 9.9999e-06 0.00158 0.35023 1 0.76954 1 0.145 0.983 1 1 MUC5B 30 (4%) 638 0.45709 1 0.68784 1 0.4776 1 0.58035 1 0.11516 0.904 0.50964 1 0.84446 1 0.4397 1 9.9999e-06 0.00158 0.98856 1 0.78405 1 0.38625 1 1 1 KDM6A 11 (2%) 657 0.57762 1 0.055905 0.68 0.37072 1 1 1 NA NA 0.60901 1 1 1 NA NA 0.01584 0.301 NA NA NA NA 0.00036 0.0244 1 1 TDG 5 (1%) 663 0.23669 1 0.45872 1 1 1 0.11556 0.904 0.35098 1 1 1 0.66517 1 NA NA 0.0017 0.0701 NA NA NA NA 0.47711 1 1 1 NFE2L2 10 (1%) 658 0.89745 1 0.011057 0.25 0.7635 1 0.78109 1 1 1 1 1 1 1 NA NA 0.46186 1 NA NA NA NA 0.40756 1 1 1 ATM 16 (2%) 652 0.9622 1 0.10145 0.9 0.01035 0.246 0.00141 0.0669 0.44913 1 0.43455 1 0.43227 1 NA NA 0.12187 0.904 NA NA NA NA 0.56206 1 0.50713 1 ZNF814 13 (2%) 655 0.21139 1 0.24183 1 0.14676 0.986 0.26363 1 0.43818 1 1 1 0.042126 0.571 NA NA 0.00045 0.0285 NA NA NA NA 0.33869 1 1 1 DNMT3A 10 (1%) 658 0.12941 0.93 0.95634 1 0.32947 1 0.35085 1 0.51343 1 0.60087 1 0.32321 1 NA NA 0.46325 1 NA NA NA NA 0.4084 1 0.4315 1 CDK12 9 (1%) 659 0.91159 1 0.042118 0.571 0.68107 1 0.69643 1 1 1 0.6231 1 0.50117 1 NA NA 0.66778 1 NA NA NA NA 1 1 1 1 CSGALNACT2 8 (1%) 660 0.10298 0.9 0.48616 1 0.75051 1 0.49388 1 1 1 0.60099 1 0.45575 1 NA NA 0.00297 0.101 NA NA NA NA 0.13325 0.951 1 1 PIK3CA 14 (2%) 654 0.8299 1 0.49292 1 0.58928 1 0.51055 1 1 1 0.41163 1 0.087459 0.9 NA NA 0.39225 1 NA NA NA NA 0.53605 1 0.57297 1 KIAA1751 8 (1%) 660 0.96742 1 0.101 0.9 0.6112 1 0.80952 1 0.51388 1 0.60099 1 0.72175 1 0.53337 1 1 1 NA NA NA NA 0.64455 1 1 1 MTOR 32 (5%) 636 0.072541 0.8 0.041519 0.571 0.32561 1 0.65241 1 1 1 0.17421 1 0.011847 0.261 0.013645 0.276 0.0198 0.352 NA NA NA NA 0.77291 1 0.71081 1 RIMBP3 5 (1%) 663 0.33223 1 0.3076 1 0.62831 1 0.089569 0.9 1 1 1 1 0.34503 1 NA NA 0.080189 0.855 NA NA NA NA 1 1 1 1 ZNF598 11 (2%) 657 0.74147 1 0.47917 1 0.60269 1 0.86723 1 0.02041 0.352 0.099711 0.9 0.34709 1 0.3614 1 2e-05 0.00237 NA NA NA NA 0.21662 1 0.50713 1 GPR50 5 (1%) 663 0.45448 1 0.31149 1 0.76411 1 0.85541 1 NA NA 1 1 0.34503 1 NA NA 0.60366 1 NA NA NA NA 0.47378 1 1 1 CCDC120 4 (1%) 664 0.19001 1 0.75103 1 0.1144 0.904 0.14863 0.986 1 1 1 1 1 1 NA NA 0.72334 1 NA NA NA NA 1 1 0.18991 1 SLC6A14 5 (1%) 663 0.72759 1 0.59895 1 0.21821 1 0.17239 1 0.092959 0.9 1 1 0.34503 1 NA NA 0.24703 1 NA NA NA NA 1 1 1 1 CYP4F11 5 (1%) 663 0.82762 1 0.49491 1 0.14104 0.983 0.04535 0.598 0.51303 1 0.46122 1 1 1 NA NA 0.34182 1 NA NA NA NA 1 1 1 1 STAG2 14 (2%) 654 0.9622 1 0.014539 0.282 0.16128 1 0.091839 0.9 1 1 0.66208 1 0.25632 1 NA NA 0.16528 1 NA NA NA NA 0.49466 1 1 1 SKI 9 (1%) 659 0.57851 1 0.74317 1 0.63042 1 0.69743 1 0.44252 1 1 1 0.72554 1 NA NA 0.00187 0.071 0.76902 1 NA NA 0.26752 1 1 1 ARID1A 19 (3%) 649 0.74861 1 0.77578 1 0.35117 1 0.66991 1 0.10776 0.904 0.71344 1 0.47006 1 0.58713 1 0.11334 0.904 NA NA NA NA 0.01431 0.282 0.24324 1 EGFR 7 (1%) 661 0.0049895 0.139 0.70478 1 0.01229 0.262 0.0034 0.104 0.44009 1 0.26314 1 0.4319 1 NA NA 0.25997 1 NA NA NA NA 1 1 1 1 DPCR1 8 (1%) 660 0.60711 1 0.22615 1 0.20267 1 0.67363 1 NA NA 0.040711 0.571 0.72175 1 NA NA 0.73994 1 NA NA NA NA 0.64698 1 1 1 GUSB 4 (1%) 664 0.59336 1 0.057811 0.686 0.22257 1 0.33163 1 NA NA 1 1 1 1 NA NA 0.72134 1 NA NA NA NA 1 1 1 1 MED16 4 (1%) 664 0.034978 0.519 0.82826 1 0.40982 1 0.32762 1 0.091339 0.9 1 1 0.60995 1 NA NA 0.095849 0.9 NA NA NA NA 1 1 1 1 PTCH1 8 (1%) 660 0.046376 0.602 0.29451 1 0.25858 1 0.077009 0.83 1 1 1 1 1 1 NA NA 0.63017 1 NA NA NA NA 0.64198 1 1 1 AHNAK2 33 (5%) 635 0.77312 1 0.23473 1 0.17128 1 0.11997 0.904 0.12243 0.904 0.56268 1 0.57377 1 0.8572 1 0.00161 0.0701 0.65443 1 0.14488 0.983 0.00455 0.131 0.65395 1 RLIM 9 (1%) 659 0.59534 1 0.12931 0.93 0.72951 1 0.76398 1 1 1 1 1 1 1 NA NA 0.24936 1 NA NA NA NA 0.67618 1 1 1 SLC23A1 7 (1%) 661 0.34218 1 0.30777 1 0.54171 1 1 1 0.3489 1 0.20625 1 0.23911 1 NA NA 1 1 NA NA NA NA 0.2691 1 1 1 STAM 6 (1%) 662 0.71429 1 0.43952 1 0.00049 0.0291 0.00168 0.0701 0.04698 0.602 0.099711 0.9 0.66972 1 NA NA 0.074339 0.811 NA NA NA NA 1 1 0.039031 0.57 RHEB 4 (1%) 664 0.83483 1 0.29684 1 0.8765 1 0.82662 1 NA NA 0.37084 1 0.11904 0.904 NA NA 1 1 NA NA NA NA 0.403 1 1 1 SLC4A8 6 (1%) 662 0.4798 1 0.38246 1 0.55635 1 0.66527 1 NA NA 1 1 0.66972 1 NA NA 0.10334 0.9 NA NA NA NA 1 1 1 1 RUFY3 7 (1%) 661 0.64742 1 0.56412 1 0.94671 1 0.88818 1 1 1 0.53875 1 0.4319 1 NA NA 0.31151 1 NA NA NA NA 0.59525 1 0.34467 1 PCK1 6 (1%) 662 0.1959 1 0.42636 1 0.26481 1 0.14827 0.986 1 1 0.60099 1 1 1 NA NA 1 1 NA NA NA NA 0.53546 1 1 1 TXNIP 8 (1%) 660 0.47199 1 0.60974 1 0.14295 0.983 0.29976 1 0.02012 0.352 0.32016 1 1 1 NA NA 1 1 NA NA NA NA 1 1 0.34467 1 RNF128 5 (1%) 663 0.59487 1 0.91252 1 0.46912 1 0.14288 0.983 NA NA 1 1 0.66517 1 NA NA 0.17102 1 NA NA NA NA 0.17421 1 0.24507 1 ZFYVE26 9 (1%) 659 0.48529 1 0.26903 1 0.67847 1 0.69773 1 NA NA 0.26314 1 1 1 NA NA 0.87851 1 NA NA NA NA 1 1 1 1 FAM160B2 4 (1%) 664 0.22292 1 0.74609 1 0.31279 1 0.65775 1 NA NA 0.37084 1 0.60995 1 NA NA 0.38402 1 NA NA NA NA 1 1 1 1 FAM47A 6 (1%) 662 0.022987 0.376 0.34854 1 0.59927 1 0.56884 1 NA NA 0.46122 1 0.019828 0.352 NA NA 0.65451 1 NA NA NA NA 1 1 1 1 ATP1A1 10 (1%) 658 0.23208 1 0.36545 1 0.29248 1 0.77878 1 NA NA 0.092088 0.9 0.50707 1 NA NA 0.46441 1 NA NA NA NA 0.40605 1 1 1 SH3BP2 4 (1%) 664 0.53337 1 0.59514 1 1 1 0.65433 1 NA NA 1 1 0.60995 1 NA NA 0.095799 0.9 NA NA NA NA 0.40402 1 1 1 FAM200A 5 (1%) 663 0.66984 1 0.60301 1 0.84011 1 0.60356 1 1 1 1 1 0.049471 0.626 NA NA 0.46509 1 NA NA NA NA 1 1 1 1 RTL1 7 (1%) 661 0.0082465 0.212 0.60905 1 0.01092 0.25 0.081109 0.855 1 1 0.15107 0.989 0.10213 0.9 NA NA 0.15841 1 NA NA NA NA 1 1 1 1 NASP 4 (1%) 664 0.10617 0.904 0.34251 1 0.22032 1 0.32991 1 NA NA 1 1 0.11904 0.904 NA NA 0.03473 0.519 NA NA NA NA 1 1 0.24507 1 RPL7A 3 (0%) 665 0.75286 1 0.19983 1 0.59118 1 1 1 NA NA 0.14286 0.983 0.55484 1 NA NA 0.02266 0.376 NA NA NA NA 0.31909 1 1 1 UIMC1 5 (1%) 663 0.0555 0.68 0.5318 1 0.29464 1 0.04477 0.598 1 1 0.53875 1 0.66517 1 NA NA 1 1 NA NA NA NA 1 1 1 1 TCEB1 3 (0%) 665 0.32505 1 0.1993 1 0.81452 1 0.43021 1 NA NA 1 1 1 1 NA NA 0.68289 1 NA NA NA NA 0.3194 1 0.18991 1 SFMBT1 3 (0%) 665 0.11489 0.904 0.32228 1 1 1 1 1 NA NA 1 1 0.27167 1 NA NA 1 1 NA NA NA NA 1 1 1 1 SLC16A1 3 (0%) 665 0.41585 1 0.19983 1 1 1 1 1 NA NA 1 1 1 1 NA NA 1 1 NA NA NA NA 0.31887 1 0.18991 1 PAM 4 (1%) 664 0.22298 1 0.96147 1 0.77794 1 1 1 0.35121 1 1 1 1 1 NA NA 0.094809 0.9 NA NA 0.39907 1 0.32125 1 1 1 TMCO3 7 (1%) 661 0.523 1 0.56546 1 0.34013 1 0.62579 1 0.43928 1 1 1 0.23911 1 NA NA 1 1 NA NA NA NA 0.0315 0.482 0.29658 1 CCDC82 6 (1%) 662 0.35594 1 0.51417 1 0.87791 1 1 1 1 1 1 1 0.18838 1 NA NA 0.25388 1 NA NA NA NA 1 1 1 1 NFAT5 8 (1%) 660 0.77243 1 0.74375 1 0.34759 1 0.61223 1 1 1 0.60901 1 0.72175 1 NA NA 0.74293 1 NA NA NA NA 0.64303 1 1 1 HNF1B 3 (0%) 665 0.10916 0.904 0.76548 1 0.12283 0.904 0.18356 1 NA NA 0.26553 1 0.27167 1 NA NA 0.40045 1 NA NA NA NA NA NA 1 1 OR2L8 7 (1%) 661 0.21424 1 0.5668 1 0.56824 1 0.49448 1 NA NA 0.15107 0.989 0.23911 1 NA NA 0.12411 0.906 NA NA NA NA 1 1 1 1 IDUA 5 (1%) 663 0.69083 1 0.21325 1 0.84143 1 0.60687 1 NA NA 1 1 0.66517 1 NA NA 0.00184 0.071 NA NA NA NA 0.17313 1 1 1 ZC3H18 6 (1%) 662 0.13687 0.969 0.77722 1 1 1 0.76336 1 NA NA 1 1 0.41766 1 NA NA 0.82108 1 NA NA NA NA 0.53991 1 1 1 GAPDHS 5 (1%) 663 0.3071 1 0.39617 1 0.91878 1 0.60392 1 NA NA 1 1 1 1 NA NA 0.24811 1 NA NA NA NA 0.17403 1 1 1 GPR137 4 (1%) 664 0.75592 1 0.38811 1 0.87741 1 0.82389 1 NA NA 0.46122 1 1 1 NA NA 1 1 NA NA NA NA 1 1 1 1 GFM1 3 (0%) 665 0.70631 1 0.029487 0.474 0.68922 1 0.74168 1 NA NA 0.26553 1 1 1 NA NA 0.00081999 0.0458 NA NA NA NA 1 1 1 1 FAT1 22 (3%) 646 0.5523 1 0.23055 1 0.26419 1 0.29414 1 0.29458 1 1 1 0.82252 1 NA NA 0.00138 0.0669 0.8975 1 NA NA 0.091729 0.9 0.62417 1 RRP12 9 (1%) 659 0.79196 1 0.11577 0.904 1 1 1 1 NA NA 1 1 0.069623 0.777 NA NA 0.57404 1 NA NA NA NA 1 1 0.34467 1