rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(3), COPS5(1), EP300(16), HIF1A(4), JUN(2), NOS3(4), P4HB(2), VHL(245) 16864926 279 254 173 19 9 11 30 80 146 3 5.78e-08 1.55e-15 6.84e-13 2 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(2), EIF1(2), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(2), EIF2S2(2), EIF2S3(2), FLT1(10), FLT4(14), HIF1A(4), HRAS(1), KDR(6), NOS3(4), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(3), PXN(3), SHC1(4), VHL(245) 34047014 334 280 225 33 20 25 37 95 155 2 3.84e-07 2.89e-15 6.84e-13 3 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(4), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC4(6), ANAPC5(3), ANAPC7(2), BTRC(2), CDC16(4), CDC20(3), CDC23(2), CDC27(14), CUL1(5), CUL2(4), CUL3(13), FBXW11(2), FBXW7(6), FZR1(4), RBX1(1), SKP2(1), SMURF2(4), TCEB1(4), TCEB2(1), UBA1(4), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), VHL(245), WWP1(8), WWP2(4) 40744239 356 305 248 31 18 24 45 105 162 2 1.09e-08 3.33e-15 6.84e-13 4 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(2), MAX(5), MYC(2), SP1(2), SP3(2), TP53(50), WT1(3) 6959343 66 56 57 4 5 7 5 21 25 3 0.000164 5.44e-15 8.38e-13 5 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(2), DNAJC3(2), EIF2S2(2), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6), TP53(50) 10030074 68 57 56 6 6 11 5 17 25 4 0.00132 7.96e-08 9.81e-06 6 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(4), AKT1(3), ATM(20), BAX(1), CDKN1A(3), CPB2(6), CSNK1A1(2), FHL2(1), HIF1A(4), IGFBP3(1), NFKBIB(2), TP53(50) 20275174 97 81 84 6 8 10 10 29 35 5 1.54e-05 3.58e-07 3.68e-05 7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), ARF3(3), CDK2(2), CDK4(6), CDKN1A(3), CDKN1B(1), CDKN2A(5), CFL1(1), E2F1(1), E2F2(1), PRB1(10), TP53(50) 8179625 84 66 67 11 5 7 8 21 38 5 0.0176 7.89e-07 6.94e-05 8 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), AKT2(5), AKT3(3), GRB2(2), ILK(4), MAPK3(3), PDK1(1), PIK3CA(14), PIK3CD(2), PTEN(34), PTK2B(3), RBL2(5), SHC1(4), SOS1(9) 20233576 92 80 85 6 7 17 10 24 31 3 3.43e-05 2.42e-06 0.000186 9 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(9), CDKN2A(5), E2F1(1), MYC(2), PIK3CA(14), PIK3R1(5), POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), RAC1(1), RB1(4), TP53(50) 19807798 105 87 90 12 8 21 8 33 30 5 0.000272 0.000539 0.0369 10 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(3), BCAR1(6), CDKN1B(1), GRB2(2), ILK(4), ITGB1(7), MAPK3(3), PDK2(3), PIK3CA(14), PIK3R1(5), PTEN(34), PTK2(3), SHC1(4), SOS1(9) 19180015 98 84 91 13 6 16 9 27 36 4 0.0201 0.00411 0.253 11 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(10), HLA-DRA(1), HLA-DRB1(6) 2164498 18 17 12 3 1 4 1 2 9 1 0.547 0.0101 0.566 12 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), B3GNT1(2), FUT1(1), FUT2(2), GCNT2(22), ST8SIA1(2) 5908503 30 29 14 2 3 1 1 6 19 0 0.277 0.0110 0.566 13 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(3), ACADM(1), ACADS(3), ACAT1(1), ECHS1(3), HADHA(4) 5419468 15 15 14 0 3 2 4 5 0 1 0.00868 0.0476 1.000 14 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(3), ATM(20), BAX(1), CCNE1(3), CDK2(2), CDK4(6), CDKN1A(3), E2F1(1), PCNA(4), RB1(4), TIMP3(4), TP53(50) 18256999 101 70 85 11 8 10 11 24 42 6 0.00296 0.0564 1.000 15 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(1), CD3E(2), CD3G(2), CD4(10) 3265447 16 15 10 2 1 2 1 3 8 1 0.528 0.0584 1.000 16 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(20), CDC25A(1), CDC25B(1), CDC25C(3), CDK2(2), CDK4(6), CHEK1(1), MYT1(5), RB1(4), TP53(50), WEE1(2) 17821606 95 74 82 13 7 11 12 28 32 5 0.0105 0.0628 1.000 17 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT1(3), GOT2(2), TAT(2), TYR(5) 4732052 15 15 15 1 2 1 3 4 5 0 0.149 0.0661 1.000 18 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(5), AKT3(3), CDKN1A(3), ELK1(1), GRB2(2), HRAS(1), MAP2K2(1), NGFR(1), NTRK1(8), PIK3CA(14), PIK3CD(2), SHC1(4), SOS1(9) 15871468 57 52 51 6 4 14 6 25 7 1 0.00223 0.0677 1.000 19 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), ECHS1(3), EHHADH(6), HADHA(4) 4888973 15 15 14 1 1 3 4 4 3 0 0.0385 0.0777 1.000 20 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(20), ATR(12), CDC25C(3), CHEK1(1), CHEK2(2), TP53(50) 16160042 88 71 78 11 8 10 10 28 29 3 0.00999 0.0862 1.000 21 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), ARG1(1), GLS(7), OAT(2), PRODH(4) 5565788 16 16 16 1 1 3 5 4 3 0 0.0626 0.0943 1.000 22 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(8), PDXK(3), PDXP(2), PSAT1(2) 4789589 15 14 15 1 3 1 1 6 4 0 0.127 0.108 1.000 23 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(3), GGT1(4), SHMT1(2), SHMT2(5) 4094910 14 14 14 2 1 1 4 5 3 0 0.253 0.118 1.000 24 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASDHPPT(3), AASS(9), KARS(1) 4802785 15 15 15 2 0 3 3 4 5 0 0.276 0.125 1.000 25 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(8), EGF(5), EGFR(10), GRB2(2), MET(22), PDGFRA(8), PRKCA(2), SH3GLB1(3), SH3GLB2(1), SH3KBP1(3), SRC(4) 19520947 71 63 65 8 5 13 10 27 16 0 0.00522 0.130 1.000 26 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3E(2), CD3G(2), HLA-A(6), ICAM1(3), ITGAL(7), ITGB2(2), PRF1(1) 8328704 26 24 26 2 2 6 3 10 4 1 0.0199 0.131 1.000 27 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(5), AASDHPPT(3), AASS(9), KARS(1) 7059407 20 20 20 2 0 4 4 6 6 0 0.133 0.133 1.000 28 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), EGFR(10), IGF1R(3), MYC(2), POLR2A(13), PPP2CA(1), PRKCA(2), RB1(4), TEP1(9), TERF1(2), TERT(10), TNKS(6), TP53(50), XRCC5(4) 27945408 119 93 107 18 16 19 11 35 33 5 0.000755 0.136 1.000 29 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4A1(1), EIF4A2(4), EIF4B(5), EIF4E(2), EIF4EBP1(1), EIF4G1(5), EIF4G2(4), EIF4G3(7), MKNK1(2), PDK2(3), PIK3CA(14), PIK3R1(5), PPP2CA(1), PTEN(34), RPS6KB1(2), TSC1(6), TSC2(13) 27738762 112 100 105 14 7 18 13 31 38 5 0.00241 0.142 1.000 30 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF4E(2), EIF4EBP1(1), GSK3B(3), IGF1R(3), INPPL1(4), PDK2(3), PIK3CA(14), PIK3R1(5), PPP2CA(1), PTEN(34), RPS6KB1(2) 19725098 81 72 74 11 5 13 7 20 33 3 0.0184 0.187 1.000 31 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(3), ACAT1(1), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4) 8443021 21 21 20 1 1 4 5 8 3 0 0.0143 0.188 1.000 32 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(2), CD3E(2), CD3G(2), CD4(10), CD58(1), CD8A(1), IL3(1), KITLG(2) 6256192 23 20 17 2 1 3 2 6 10 1 0.294 0.193 1.000 33 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(10), CD80(1), HLA-DRA(1), HLA-DRB1(6), IL4(1) 3769144 20 19 14 4 2 4 2 2 9 1 0.553 0.203 1.000 34 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(10), DAXX(6), HRAS(1), PAX3(2), PML(6), RARA(4), RB1(4), SIRT1(6), SP100(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TP53(50) 18504901 94 78 85 16 10 13 11 25 30 5 0.0161 0.214 1.000 35 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(4), CPS1(6), GLS(7), GOT1(3) 7769460 21 21 21 2 0 4 2 9 6 0 0.148 0.256 1.000 36 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(5), EGFR(10), ERBB3(8), NRG1(6), UBE2D1(2) 10301766 31 31 29 4 5 3 4 11 8 0 0.106 0.262 1.000 37 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(2), TAT(2) 2651351 7 7 7 1 1 1 2 0 3 0 0.424 0.275 1.000 38 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP2(29), RANGAP1(1) 8187800 32 28 26 4 2 7 4 9 10 0 0.0658 0.298 1.000 39 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(2), HLA-DRA(1), HLA-DRB1(6), IL3(1) 2792284 10 9 10 2 0 3 2 2 3 0 0.450 0.309 1.000 40 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(7), EGF(5), EGFR(10), HGS(3), RAB5A(1), TFRC(3) 12803255 29 28 27 0 5 1 6 9 8 0 0.00152 0.310 1.000 41 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(5), AMD1(2), BHMT(7), CTH(2), DNMT1(25), DNMT3A(16), DNMT3B(3), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), MTAP(2), MTFMT(1), TAT(2) 20594276 74 66 55 10 5 7 13 17 32 0 0.127 0.336 1.000 42 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 513607 1 1 1 1 0 0 0 0 1 0 1.000 0.349 1.000 43 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(2) 1171958 4 3 4 0 0 1 1 1 1 0 0.376 0.351 1.000 44 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB1A(3), RAB3A(2), RAB4A(1), RAB5A(1), RAB6A(1) 4248633 10 10 10 1 1 1 2 3 3 0 0.261 0.352 1.000 45 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(3), GBA3(3), LPO(1), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), TPO(4), TYR(5) 9594681 28 27 28 4 2 2 10 9 5 0 0.120 0.370 1.000 46 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), ACYP1(1), ECHS1(3), EHHADH(6), GCDH(3), HADHA(4), SDHB(1) 7839298 19 19 16 1 1 3 4 6 5 0 0.0409 0.377 1.000 47 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(3), HADH(1), HADHA(4), HADHB(4), HSD17B4(2), MECR(4), PPT1(1) 8470284 19 18 19 1 2 3 6 7 1 0 0.0185 0.377 1.000 48 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(4), GBA(3), GBA3(3), GGT1(4), SHMT1(2), SHMT2(5) 5522244 21 21 18 4 1 1 4 8 7 0 0.327 0.394 1.000 49 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3E(2), CD3G(2), CD80(1), CD86(3), CTLA4(3), GRB2(2), HLA-DRA(1), HLA-DRB1(6), ICOS(3), ITK(2), LCK(1), PIK3CA(14), PIK3R1(5), PTPN11(2) 12644259 48 46 42 7 4 15 5 13 11 0 0.0598 0.404 1.000 50 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ARPC1B(2), ARPC2(9), CDC42(1), PAK1(3), PDGFRA(8), PIK3CA(14), PIK3R1(5), RAC1(1), WASL(7) 13531502 52 50 41 8 3 12 3 20 14 0 0.0897 0.422 1.000 51 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 726871 1 1 1 1 0 0 1 0 0 0 0.957 0.541 1.000 52 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(2), COQ6(2), COQ7(1), NDUFA13(2), NDUFB11(1) 4130964 8 8 8 1 3 1 0 3 1 0 0.334 0.543 1.000 53 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2), LIPT1(1) 1538815 3 3 3 1 0 0 0 3 0 0 0.815 0.545 1.000 54 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(3) 1715205 5 5 5 2 1 1 1 2 0 0 0.717 0.555 1.000 55 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(1), CD3E(2), CD3G(2), CD4(10), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8) 11196822 37 33 31 5 3 5 3 12 13 1 0.183 0.556 1.000 56 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(5), BHMT(7), CTH(2), DNMT1(25), DNMT3A(16), DNMT3B(3), MARS(3), MARS2(4), MAT1A(1), MAT2B(1) 17236237 67 60 48 8 3 6 11 15 32 0 0.131 0.560 1.000 57 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(1), NDUFA1(1), SDHA(9), SDHB(1), SDHD(2), UQCRC1(1) 6536667 18 16 18 3 3 7 3 5 0 0 0.101 0.575 1.000 58 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(1), IFNGR1(3), IFNGR2(2), IKBKB(3), JAK2(7), NFKB1(2), NFKBIA(2), RB1(4), RELA(6), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TP53(50), USH1C(4), WT1(3) 18234504 90 74 78 17 7 11 8 27 31 6 0.118 0.591 1.000 59 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(3), ITGAL(7), ITGAM(9), ITGB2(2), SELE(6), SELL(2) 10626766 32 32 32 5 3 9 6 8 6 0 0.0562 0.593 1.000 60 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(5), ENO2(2), ENO3(2), GOT1(3), GOT2(2), PAH(6), TAT(2), YARS(1) 8346172 23 21 23 3 2 2 6 6 7 0 0.122 0.605 1.000 61 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HSD17B4(2), NTAN1(1), SIRT1(6), SIRT5(1), SIRT7(2), VNN2(1) 11898675 29 27 28 4 3 6 6 6 8 0 0.0501 0.611 1.000 62 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(8), CPT1A(2), LEP(1), LEPR(5), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKAG1(5), PRKAG2(6) 14619347 33 32 30 3 2 6 8 6 11 0 0.00967 0.650 1.000 63 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(1), CD3E(2), CD3G(2), CD8A(1), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8) 10584486 28 25 28 4 3 5 3 11 6 0 0.104 0.651 1.000 64 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(9), ATM(20), ATR(12), CCNA1(8), CCNE1(3), CDC25A(1), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(5), E2F1(1), GSK3B(3), HDAC1(2), RB1(4), SKP2(1), TGFB2(3), TGFB3(1), TP53(50) 30039333 136 103 118 23 11 16 15 38 50 6 0.0150 0.686 1.000 65 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFA(1), DFFB(1), HMGB1(3), HMGB2(3), TOP2A(5), TOP2B(7) 10113287 21 20 21 2 3 3 2 6 6 1 0.181 0.695 1.000 66 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(2), CD4(10), HLA-DRA(1), HLA-DRB1(6), IL1B(1), IL4(1), IL5RA(2) 5153677 23 22 17 5 1 5 3 2 11 1 0.684 0.701 1.000 67 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(1), BMPR1B(2), BMPR2(5) 6194918 13 11 13 0 0 2 3 5 3 0 0.0167 0.706 1.000 68 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(5), FH(2), IDH1(2), IDH2(6), MDH1(2), MDH2(1), SDHB(1), SUCLA2(2) 8974879 21 20 18 3 1 3 1 7 9 0 0.210 0.709 1.000 69 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(1), IDI1(1), IDI2(3), SQLE(1) 4384154 8 8 8 1 1 1 0 4 2 0 0.494 0.710 1.000 70 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(3), CAMK1G(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CAMKK1(4), CAMKK2(3), SYT1(1) 11606698 24 24 23 2 2 3 4 9 6 0 0.0623 0.713 1.000 71 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(5), EGFR(10), GRB2(2), HRAS(1), MAPK3(3), PTPRB(5), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SPRY1(1), SPRY2(3), SPRY4(10), SRC(4) 25040123 71 61 62 7 5 16 9 19 22 0 0.00455 0.721 1.000 72 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(3) 2260400 4 4 4 1 0 0 1 1 2 0 0.830 0.728 1.000 73 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(2), CD3G(2), IL2RA(2), IL4(1), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TGFBR3(3), TOB1(5), TOB2(3) 10680453 26 25 26 4 1 4 6 10 5 0 0.151 0.741 1.000 74 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(2), SPCS1(3) 3085202 5 5 5 1 0 0 1 4 0 0 0.601 0.757 1.000 75 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(6), CTH(2), GOT1(3), GOT2(2), LDHB(2), LDHC(3), MPST(2) 6773580 20 20 18 4 1 0 3 7 9 0 0.644 0.765 1.000 76 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), HPRT1(1), IMPDH1(1), MTHFD2(2), POLB(2), POLD1(7), POLG(6), PRPS2(4), RRM1(3) 12380440 29 28 27 3 2 5 2 11 9 0 0.0886 0.768 1.000 77 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(2), GSR(1), GSS(1), NFKB1(2), NOX1(7), RELA(6), TNF(1), XDH(7) 9878723 27 24 22 3 1 3 6 6 10 1 0.193 0.769 1.000 78 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(6), GLB1(5), GNS(4), GUSB(7), HEXA(4), IDS(2), IDUA(6), LCT(7), NAGLU(2) 14285623 44 37 39 7 7 5 6 17 9 0 0.0740 0.777 1.000 79 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HBXIP(1), HRAS(1), PTK2B(3), SHC1(4), SOS1(9), SRC(4) 8688524 24 22 24 4 1 8 2 8 5 0 0.172 0.777 1.000 80 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(3), AKT2(5), AKT3(3), BAD(1), BTK(1), CDKN2A(5), DAPP1(2), GRB2(2), GSK3A(3), GSK3B(3), IARS(4), IGFBP1(1), INPP5D(2), PDK1(1), PIK3CA(14), PPP1R13B(4), PTEN(34), RPS6KA1(8), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SOS1(9), SOS2(7), TEC(6), YWHAE(1) 35861360 130 108 118 20 6 23 18 35 44 4 0.00854 0.789 1.000 81 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(2), MTMR2(3), MTMR6(1), NFS1(2), PHPT1(1), THTPA(1), TPK1(2) 6441584 12 12 12 2 2 2 2 6 0 0 0.290 0.789 1.000 82 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(3), IFNGR2(2), JAK1(7), JAK2(7), STAT1(6) 8316258 25 25 25 5 3 0 3 14 5 0 0.496 0.800 1.000 83 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), FUT1(1), FUT2(2), FUT3(2), FUT4(2), FUT6(4), FUT7(1), GCNT2(22), ST3GAL6(1), ST8SIA1(2) 15127214 51 44 34 6 7 4 4 11 25 0 0.177 0.805 1.000 84 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(3), DNMT1(25), MTNR1B(1), PTAFR(2), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), TBXA2R(4) 10557747 47 44 32 9 3 4 7 11 22 0 0.477 0.807 1.000 85 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(2), GRIA2(4), PPP1R1B(1) 3691951 7 7 7 2 1 1 1 3 1 0 0.649 0.824 1.000 86 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), FPGS(3), GGH(2) 6105520 22 20 22 6 4 5 4 7 2 0 0.233 0.826 1.000 87 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(2), CD4(10), FYN(2), HLA-DRA(1), HLA-DRB1(6), LCK(1), PTPRC(8), ZAP70(1) 8778121 33 30 27 6 1 6 2 10 13 1 0.474 0.832 1.000 88 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1) 10131170 19 17 19 2 2 3 3 5 6 0 0.134 0.834 1.000 89 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(1), IDI1(1), SQLE(1) 3294606 5 5 5 1 0 1 0 2 2 0 0.743 0.835 1.000 90 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(1), RDH11(4), RDH13(1) 4715015 9 9 9 2 2 0 1 6 0 0 0.496 0.839 1.000 91 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(3), ITGA4(3), ITGAL(7), ITGB1(7), ITGB2(2), SELE(6), SELL(2) 12218157 33 32 33 6 2 9 7 8 7 0 0.131 0.848 1.000 92 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(3), ALDOB(3), ALDOC(1), TPI1(2) 3865278 9 9 9 5 0 0 3 1 5 0 0.982 0.848 1.000 93 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(8), CCNE1(3), CCNE2(4), CDK2(2), CDK4(6), CDKN1B(1), CDKN2A(5), E2F1(1), E2F2(1), PRB1(10) 8842785 41 32 29 9 1 4 4 7 24 1 0.668 0.854 1.000 94 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(1) 2032463 2 2 2 1 0 0 0 1 1 0 0.774 0.872 1.000 95 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(2), GALT(3), UGDH(1), UXS1(1) 3998272 7 7 7 2 0 1 3 3 0 0 0.598 0.874 1.000 96 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(22), MAP2(4), PPP1CA(1), PPP2CA(1), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAR2A(1), PRKAR2B(3), PRKCE(4) 18075505 49 46 46 7 6 3 3 21 15 1 0.0990 0.876 1.000 97 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(6), F13A1(3), F2(4), F2R(2), FGA(4), FGB(2), FGG(6), PLAT(4), PLAU(5), PLG(8), SERPINB2(1) 13504810 45 42 40 9 6 4 5 19 11 0 0.220 0.882 1.000 98 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(1), CDKN1A(3), CHEK1(1), NEK1(3), WEE1(2) 7392778 11 10 11 1 0 2 0 5 3 1 0.314 0.883 1.000 99 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), BAD(1), CASP9(2), CHUK(2), GHR(1), NFKB1(2), NFKBIA(2), PIK3CA(14), PIK3R1(5), PPP2CA(1), RELA(6) 14209985 39 39 31 6 2 12 3 12 9 1 0.0817 0.890 1.000 100 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), INS(1), INSR(6), IRS1(5), JUN(2), MAPK3(3), PIK3CA(14), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(7), SHC1(4), SLC2A4(3), SOS1(9), SRF(1) 24921860 74 69 67 11 8 19 8 25 14 0 0.0113 0.896 1.000 101 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(1), MMP2(7), MMP9(1), RECK(1), TIMP2(1), TIMP3(4) 7482415 16 15 13 3 2 3 1 3 7 0 0.452 0.902 1.000 102 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(4), HSD17B1(1), HSD17B2(1), HSD17B4(2), HSD17B7(1), HSD3B1(1) 8078703 13 12 13 2 2 3 3 4 1 0 0.209 0.906 1.000 103 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNB1(3), HTR2C(1), PLCB1(4), TUB(4) 7113832 14 13 14 2 1 2 0 10 1 0 0.283 0.906 1.000 104 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(1), CDC25A(1), CDC25B(1), CDC25C(3), MNAT1(1), SHH(3), XPO1(8) 8685207 19 19 19 4 1 2 7 7 2 0 0.275 0.912 1.000 105 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(2), GALT(3), UGDH(1), UGP2(1), UXS1(1) 5057310 8 8 8 2 0 1 4 3 0 0 0.496 0.913 1.000 106 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 1643608 1 1 1 0 0 0 0 1 0 0 0.838 0.915 1.000 107 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(3) 3068084 3 3 3 1 0 1 0 2 0 0 0.830 0.916 1.000 108 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(20), ATR(12), BRCA1(9), CCNB1(1), CDC25A(1), CDC25B(1), CDC25C(3), CDKN1A(3), CHEK1(1), CHEK2(2), EP300(16), MYT1(5), PRKDC(13), RPS6KA1(8), TP53(50), WEE1(2) 43039212 147 114 129 21 9 18 17 53 45 5 0.00231 0.918 1.000 109 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDK2(2), CDKN1B(1), CUL1(5), E2F1(1), NEDD8(2), RB1(4), RBX1(1), SKP2(1) 8675384 20 19 19 4 2 2 4 2 8 2 0.461 0.919 1.000 110 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(6), CYP51A1(2), DHCR24(1), DHCR7(3), FDFT1(2), FDPS(1), GGCX(2), HSD17B7(1), IDI1(1), IDI2(3), LSS(4), MVK(1), NSDHL(3), PMVK(1), SC4MOL(1), SC5DL(1), SQLE(1), TM7SF2(3), VKORC1(1) 19285921 38 35 36 2 2 6 2 17 11 0 0.0124 0.922 1.000 111 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(3), ATM(20), BAD(1), BAX(1), BID(2), CASP7(1), CASP9(2), PRKCA(2), PTK2(3), PXN(3), STAT1(6), TLN1(14), TP53(50) 27491791 111 90 101 19 11 13 12 37 35 3 0.0185 0.929 1.000 112 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(2), FDPS(1), IDI1(1), LSS(4), MVK(1), NQO2(1), PMVK(1), SC5DL(1), SQLE(1), VKORC1(1) 11094202 17 17 17 1 0 3 2 8 4 0 0.0993 0.930 1.000 113 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(5), GABBR1(5), GPRC5A(2), GPRC5B(2), GPRC5C(1), GPRC5D(1), GRM1(5), GRM2(5), GRM3(5), GRM4(6), GRM5(9), GRM7(5), GRM8(4) 19738245 55 48 52 9 9 9 5 20 12 0 0.0552 0.933 1.000 114 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(2), NDUFA11(2), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(1), NDUFV1(2), NDUFV2(1) 7042130 24 24 23 7 0 1 3 11 9 0 0.808 0.942 1.000 115 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(5) 5259683 13 13 13 4 2 1 2 4 3 1 0.702 0.944 1.000 116 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(2), FH(2), IDH2(6), MDH1(2), OGDH(8), SDHA(9), SUCLA2(2) 9450965 31 28 28 7 1 9 0 11 10 0 0.329 0.944 1.000 117 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(10), CD8A(1), IL3(1), IL4(1), IL9(1) 6013784 14 14 8 3 0 2 2 2 7 1 0.828 0.944 1.000 118 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(3), FDFT1(2), FDPS(1), HMGCS1(2), IDI1(1), LSS(4), MVK(1), NSDHL(3), PMVK(1), SC4MOL(1), SC5DL(1), SQLE(1) 13226697 23 20 23 1 0 5 2 9 7 0 0.0407 0.945 1.000 119 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(4), ABCB4(8), ABCC1(10), ABCC3(11), GSTP1(2) 14599913 39 32 33 6 2 7 8 10 12 0 0.0996 0.945 1.000 120 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE2N(3), UBE3A(2) 10471665 19 19 19 3 1 2 2 9 5 0 0.296 0.945 1.000 121 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(4), APEX1(2), CREBBP(10), DFFA(1), DFFB(1), HMGB2(3), PRF1(1) 10462724 22 21 22 4 4 4 5 3 6 0 0.110 0.951 1.000 122 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(3), ITGA4(3), ITGAL(7), ITGAM(9), ITGB1(7), ITGB2(2), SELE(6), SELL(2), SELP(2) 16189587 44 42 44 9 3 11 9 12 9 0 0.144 0.952 1.000 123 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CCNE1(3), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), E2F1(1), HRAS(1), MAPK3(3), NFKB1(2), NFKBIA(2), PAK1(3), PIK3CA(14), PIK3R1(5), RAC1(1), RAF1(4), RB1(4), RELA(6) 20238027 65 56 54 11 5 12 7 18 19 4 0.158 0.955 1.000 124 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(3), ACADM(1), ACADS(3), ACSL1(4), ACSL3(13), ACSL4(1), CPT1A(2), CPT2(2), EHHADH(6), HADHA(4), PECR(4), SCP2(3) 16853828 46 42 34 9 2 9 7 21 6 1 0.0920 0.957 1.000 125 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(4), STX1A(1), VAMP2(1) 3211172 8 7 8 4 0 1 0 4 3 0 0.913 0.957 1.000 126 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(5), FOS(1), GRB2(2), HRAS(1), IL3(1), JAK2(7), MAPK3(3), PTPN6(3), RAF1(4), SHC1(4), SOS1(9), STAT5A(3), STAT5B(3) 17543882 46 43 45 7 6 4 8 18 10 0 0.0919 0.958 1.000 127 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(3), CAMP(1), DAG1(3), ITPKA(2), ITPKB(2) 5726775 11 10 11 3 2 1 2 1 5 0 0.736 0.961 1.000 128 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(8), CR2(4), HLA-DRA(1), HLA-DRB1(6), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8) 15076622 40 38 40 8 5 6 3 16 10 0 0.260 0.966 1.000 129 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CSAD(3), GAD1(2), GAD2(2), GGT1(4) 5683713 13 13 13 4 2 2 5 2 2 0 0.505 0.967 1.000 130 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), HLA-A(6), ITGB1(7), KLRC1(3), KLRC2(5), KLRC3(1), LAT(1), MAPK3(3), PAK1(3), PIK3CA(14), PIK3R1(5), PTK2B(3), PTPN6(3), RAC1(1), SYK(2), VAV1(4) 18711135 64 56 58 11 3 15 8 19 18 1 0.109 0.967 1.000 131 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), AKT1(3), ANXA1(1), CALM2(1), GNAS(5), GNB1(3), NFKB1(2), NOS3(4), NPPA(1), NR3C1(4), PIK3CA(14), PIK3R1(5), RELA(6), SYT1(1) 17724491 52 50 44 9 5 14 5 18 9 1 0.123 0.968 1.000 132 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(1), FUT2(2), FUT3(2), FUT6(4), ST3GAL3(3) 4672695 13 12 11 4 5 1 0 3 4 0 0.692 0.968 1.000 133 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(2), GNAS(5), GNB1(3), PPP2CA(1), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAG2(6), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3) 15126373 42 40 39 7 5 3 2 18 14 0 0.179 0.968 1.000 134 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(3), DHRS2(1), DHRSX(5), PON2(2), PON3(5), RDH11(4), RDH13(1) 8884385 21 20 16 4 3 0 3 7 8 0 0.601 0.969 1.000 135 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(1), MST1(7), MST1R(4), TNF(1) 6032580 14 14 12 4 1 1 5 2 5 0 0.756 0.970 1.000 136 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG7(6), BECN1(2), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), INS(1), PIK3C3(4), PIK3R4(5), PRKAA1(1), PRKAA2(4), ULK1(2), ULK2(3), ULK3(3) 21182040 49 46 46 7 4 4 4 24 13 0 0.109 0.971 1.000 137 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), BCMO1(1), RDH5(4) 3854221 7 7 7 3 0 0 5 1 1 0 0.790 0.972 1.000 138 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(2), CYP17A1(3), HSD11B2(1), HSD3B1(1) 6759353 11 9 11 2 1 0 1 9 0 0 0.380 0.973 1.000 139 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(6), IL3(1), IL9(1), KITLG(2), TGFB2(3), TGFB3(1) 8353125 15 15 15 3 0 1 3 7 4 0 0.583 0.973 1.000 140 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(7), GLS2(4), GLUD2(7) 4425638 18 18 16 5 1 2 3 10 2 0 0.611 0.973 1.000 141 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), DCXR(1), GUSB(7), RPE(2), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4) 17550099 42 37 40 7 3 6 11 10 12 0 0.114 0.975 1.000 142 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(3), FMOD(3), KERA(1), LUM(1) 3580606 8 8 8 3 0 1 0 5 2 0 0.790 0.976 1.000 143 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4A1(1), EIF4A2(4), EIF4E(2), EIF4EBP1(1), EIF4G1(5), EIF4G2(4), EIF4G3(7), GHR(1), IRS1(5), MAPK14(1), MAPK3(3), MKNK1(2), PABPC1(18), PDK2(3), PIK3CA(14), PIK3R1(5), PRKCA(2), PTEN(34), RPS6KB1(2) 27947935 117 100 110 22 10 22 14 32 34 5 0.0530 0.978 1.000 144 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(2), IFNAR1(3), IFNB1(3), JAK1(7), STAT1(6), STAT2(6), TYK2(7) 10778339 34 29 33 8 4 7 4 9 10 0 0.241 0.979 1.000 145 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(5), CASP8(1), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1) 8049816 14 14 14 4 0 4 4 4 2 0 0.529 0.982 1.000 146 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), HMGCL(1), OXCT1(2) 3424685 4 4 4 2 0 1 0 2 1 0 0.869 0.983 1.000 147 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(8), CCNE1(3), CDK2(2), CUL1(5), E2F1(1), RB1(4), SKP2(1) 8733824 24 23 21 5 2 3 4 3 10 2 0.389 0.984 1.000 148 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), MDH1(2), MDH2(1), ME1(1), ME3(2), PGK1(3), PGK2(1), PKLR(1), PKM2(1), RPE(2), RPIA(2), TKT(2), TKTL1(2), TKTL2(6), TPI1(2) 19919703 47 46 47 8 2 5 8 15 17 0 0.190 0.986 1.000 149 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(1), FOS(1), JUN(2), MAPK3(3), OPRK1(2), POLR2A(13), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3) 12685957 36 35 35 8 10 2 4 14 6 0 0.209 0.987 1.000 150 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(3), ACOX1(2), ACOX3(5), ELOVL2(1), ELOVL5(6), ELOVL6(1), FADS1(1), FADS2(2), FASN(9), HADHA(4), PECR(4) 14167301 38 32 35 6 4 8 4 16 6 0 0.0449 0.987 1.000 151 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLRMT(5) 13160936 36 35 33 7 4 5 6 10 11 0 0.209 0.987 1.000 152 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(4), C1S(17), C2(2), C3(8), C5(6), C6(3), C7(4), C8A(1) 17532361 46 38 33 7 4 5 2 22 13 0 0.134 0.988 1.000 153 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PGK1(3), PKLR(1), PKM2(1), RPE(2), RPIA(2), TKT(2), TPI1(2) 17800341 41 39 41 7 2 5 8 10 16 0 0.199 0.988 1.000 154 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNGR1(3), JAK1(7), JAK2(7), PTPRU(5), STAT1(6) 11401408 30 28 30 6 4 0 3 18 5 0 0.421 0.989 1.000 155 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), HMOX1(3), IL10RA(4), JAK1(7), STAT1(6), STAT3(3), STAT5A(3), TNF(1) 12086486 28 28 27 5 4 0 1 13 10 0 0.587 0.989 1.000 156 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(2), GNAS(5), GNB1(3), PRKACA(2), PRKAR1A(2) 6330917 14 14 14 4 2 1 1 9 1 0 0.732 0.989 1.000 157 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CDK2(2), CUL1(5), E2F1(1), FBXW7(6), RB1(4) 8487807 21 20 21 5 2 3 5 2 7 2 0.503 0.990 1.000 158 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(8), AGT(4), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(4), NOS3(4), REN(1) 9667579 25 24 23 5 2 4 3 10 6 0 0.298 0.990 1.000 159 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(2), EPX(3), LPO(1), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), SHMT1(2), SHMT2(5), TPO(4) 11705473 30 29 30 6 2 3 9 10 6 0 0.264 0.991 1.000 160 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(4), C1S(17), C2(2), C3(8), C5(6), C6(3), C7(4), C8A(1), MASP1(4), MASP2(1), MBL2(2) 21400601 53 45 40 8 6 6 3 24 14 0 0.0794 0.991 1.000 161 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CCL2(1), LDLR(3), LPL(3) 5223024 8 8 8 3 0 3 0 4 1 0 0.679 0.992 1.000 162 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(3), ATM(20), ATR(12), BAI1(6), BAX(1), BBC3(1), BID(2), CASP8(1), CASP9(2), CCNB1(1), CCNB2(6), CCNB3(6), CCND2(1), CCNE1(3), CCNE2(4), CCNG1(1), CCNG2(2), CD82(3), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN2A(5), CHEK1(1), CHEK2(2), FAS(2), GADD45B(1), GTSE1(4), IGFBP3(1), LRDD(1), PERP(1), PPM1D(2), PTEN(34), RCHY1(3), RFWD2(3), RRM2(1), SERPINB5(5), SESN1(2), SFN(1), STEAP3(2), THBS1(15), TNFRSF10B(1), TP53(50), TP53I3(6), TP73(4), TSC2(13), ZMAT3(1) 64756424 248 178 230 35 24 33 34 61 89 7 1.73e-05 0.992 1.000 163 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(4), F2R(2), F5(12), F7(1), FGA(4), FGB(2), FGG(6), PROC(4), PROS1(5), TFPI(2) 16338029 43 41 41 9 5 5 3 16 13 1 0.360 0.993 1.000 164 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), BAD(1), CHRNB1(4), MUSK(4), PIK3CA(14), PIK3R1(5), PTK2(3), PTK2B(3), RAPSN(1), SRC(4), TERT(10) 16372374 52 49 47 10 5 18 4 18 7 0 0.0617 0.994 1.000 165 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(3), CTSD(3), GREB1(18), HSPB2(2), MTA1(4), MTA3(3), PDZK1(1) 10599857 34 31 31 8 1 2 7 17 7 0 0.605 0.994 1.000 166 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(2), AASDH(5), AASDHPPT(3), AASS(9), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), BBOX1(2), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(9), GCDH(3), HADHA(4), PLOD1(3), PLOD2(5), PLOD3(11), SHMT1(2), SHMT2(5), TMLHE(1) 35905827 104 87 92 17 8 16 14 34 31 1 0.0290 0.994 1.000 167 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(5), AOC2(5), AOC3(2), CES1(8), ESD(1) 5734455 21 20 19 6 0 3 4 9 5 0 0.553 0.994 1.000 168 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(8), C5(6), C6(3), C7(4), C8A(1) 12856880 22 21 22 4 2 2 2 12 4 0 0.327 0.994 1.000 169 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(3), EPOR(3), GRIN1(2), HIF1A(4), JAK2(7), NFKB1(2), NFKBIA(2), RELA(6) 12667776 31 29 28 6 1 4 4 10 9 3 0.360 0.994 1.000 170 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(2), ERBB4(11), NRG2(4), NRG3(5), PRKCA(2) 9122312 24 24 24 6 3 5 3 10 3 0 0.421 0.995 1.000 171 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ECHS1(3), EHHADH(6), HADHA(4) 12143248 30 30 27 7 2 5 7 10 6 0 0.337 0.996 1.000 172 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(3), GBA(3), GBA3(3), LPO(1), MPO(6), PRDX6(2), TPO(4) 8274972 22 21 22 5 2 2 7 8 3 0 0.336 0.996 1.000 173 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(5), PCYT1A(1), PDHA1(1), PDHA2(3), SLC18A3(2) 6617312 13 13 11 4 1 2 1 3 6 0 0.801 0.996 1.000 174 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CTH(2), MUT(2) 4850611 5 5 5 2 1 0 1 1 2 0 0.890 0.996 1.000 175 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(2), GOT1(3), GOT2(2), PAH(6), TAT(2), YARS(1), YARS2(1) 8708104 17 17 17 4 1 1 4 5 6 0 0.607 0.996 1.000 176 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYC(2), RB1(4), SP1(2), SP3(2) 6742291 11 11 11 3 0 3 0 2 4 2 0.835 0.996 1.000 177 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNB1(3), JAK1(7), PTPRU(5), STAT1(6), STAT2(6), TYK2(7) 12301259 37 32 36 9 5 5 4 13 10 0 0.299 0.996 1.000 178 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(4), C1S(17), C2(2), C3(8), C5(6), C6(3), C7(4), C8A(1), C8B(2), MASP1(4) 20846979 52 44 39 8 7 5 2 24 14 0 0.101 0.996 1.000 179 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), BAD(1), CASP9(2), CDC42(1), CHUK(2), ELK1(1), HRAS(1), MAPK3(3), NFKB1(2), PIK3CA(14), PIK3R1(5), RAC1(1), RAF1(4), RALA(2), RALBP1(2), RELA(6) 19189432 50 49 41 9 2 13 5 17 12 1 0.161 0.997 1.000 180 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(3), SRP19(1), SRP68(2), SRP72(3), SRP9(1), SRPR(1) 7594500 11 10 11 3 1 3 2 5 0 0 0.504 0.997 1.000 181 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1) 23473829 54 50 50 8 5 7 4 24 14 0 0.0735 0.997 1.000 182 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(2), ARPC1B(2), ARPC2(9), CDC42(1), RAC1(1), WASF1(1), WASL(7) 8131288 24 24 18 6 1 5 0 11 7 0 0.526 0.997 1.000 183 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), ATIC(2), GART(4), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(1), SHMT1(2), SHMT2(5), TYMS(1) 17963465 33 32 33 5 3 6 3 15 6 0 0.110 0.997 1.000 184 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(10), HLA-DRA(1), HLA-DRB1(6), IFNA1(2), IFNB1(3), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(3), TGFB3(1), TNF(1) 12968985 31 29 25 6 0 9 3 8 10 1 0.361 0.997 1.000 185 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FOS(1), FYN(2), JUN(2), MAPK14(1), THBS1(15) 7214724 22 20 19 7 1 2 5 7 7 0 0.864 0.997 1.000 186 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(2), HDC(1), TH(4), TPH1(2) 5828899 11 11 11 4 2 2 3 2 2 0 0.692 0.998 1.000 187 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1), CFL1(1), CFLAR(1) 3849704 3 3 3 2 0 0 2 0 1 0 0.942 0.998 1.000 188 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(5), GPI(3), HK1(5), PFKL(3), PGAM1(1), PGK1(3), PKLR(1), TPI1(2) 9044318 26 24 24 8 4 3 3 7 9 0 0.574 0.998 1.000 189 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(1), B3GALT2(2), B3GALT5(3), B3GNT5(1), FUT1(1), FUT2(2), FUT3(2), ST3GAL3(3), ST3GAL4(2) 6991590 18 17 16 6 6 0 2 3 7 0 0.769 0.998 1.000 190 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR1(3), IFNB1(3), NFKB1(2), RELA(6), TRAF6(2) 10827165 18 18 15 4 2 6 0 2 7 1 0.502 0.998 1.000 191 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(4), JAK1(7), JAK2(7), TYK2(7) 10359495 27 26 26 8 3 0 5 9 10 0 0.714 0.998 1.000 192 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(4), JAK1(7), JAK2(7), TYK2(7) 10359495 27 26 26 8 3 0 5 9 10 0 0.714 0.998 1.000 193 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(10), G6PD(2), GCLC(4), GGT1(4), GPX1(2), GPX3(3), GPX4(2), GPX6(1), GSR(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM1(3), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), IDH1(2), IDH2(6), OPLAH(7), TXNDC12(1) 21902956 62 54 59 11 5 7 13 24 13 0 0.103 0.998 1.000 194 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), MIOX(2), UGDH(1) 8480260 19 19 17 5 1 3 4 5 6 0 0.647 0.998 1.000 195 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(20), CDC25A(1), CDC25B(1), CDC25C(3), CHEK1(1), MYT1(5), WEE1(2) 13884133 33 30 32 7 2 4 5 14 8 0 0.324 0.999 1.000 196 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(8), CCNB1(1), CCND2(1), CCNE1(3), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(5), CDKN2C(1), E2F1(1), RB1(4) 15905308 39 34 33 9 2 4 4 8 18 3 0.543 0.999 1.000 197 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(3), DPM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), KLK2(1), MAPK3(3), NGFR(1), PIK3CA(14), PIK3R1(5), PLCG1(4), RAF1(4), SHC1(4), SOS1(9) 18750835 56 53 50 11 5 14 6 21 10 0 0.139 0.999 1.000 198 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), CS(2), GRHPR(2), HAO1(1), MDH1(2), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2) 12849668 26 26 26 6 3 3 3 13 4 0 0.350 0.999 1.000 199 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(1), ACP5(2), ACP6(3), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CMBL(1), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHRS2(1), DHRSX(5), PON2(2), PON3(5) 17674096 43 41 37 9 4 7 4 14 14 0 0.307 0.999 1.000 200 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(6), GLB1(5), GNS(4), GUSB(7), HEXA(4), HGSNAT(3), HPSE(3), HPSE2(4), HYAL1(2), HYAL2(1), IDS(2), IDUA(6), LCT(7), NAGLU(2), SPAM1(8) 20450039 65 54 60 13 11 8 8 27 11 0 0.0742 0.999 1.000 201 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(6), GNA12(1), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAR2A(1), PRKAR2B(3) 10017406 24 24 24 6 3 3 3 11 4 0 0.461 0.999 1.000 202 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(7), JAK2(7), JAK3(4), PIAS1(5), PIAS3(3), PTPRU(5), SOAT1(4) 13744220 37 32 35 8 2 3 8 14 10 0 0.329 0.999 1.000 203 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(8), CD38(1), ENPP1(4), ENPP3(2), NADSYN1(1), NMNAT2(2), NNMT(1), NNT(7), NT5M(2), QPRT(1) 14586679 29 28 29 6 2 2 3 17 5 0 0.355 0.999 1.000 204 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(3), CAMK1G(3), HDAC9(4), MEF2A(3), MEF2D(1) 8146447 14 14 13 4 2 1 2 3 6 0 0.590 0.999 1.000 205 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3) 5684384 11 11 10 6 1 0 0 8 2 0 0.972 0.999 1.000 206 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(3), EGF(5), EGFR(10), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(7), JUN(2), MAP3K1(8), MAPK3(3), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SRF(1), STAT1(6), STAT3(3), STAT5A(3) 37411664 105 91 96 17 10 20 10 35 30 0 0.0375 0.999 1.000 207 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 DPM2(1), EGR1(10), HRAS(1), KLK2(1), MAP2K2(1), MAPK3(3), NGFR(1), RAF1(4) 8043076 22 22 15 6 2 1 2 8 9 0 0.827 0.999 1.000 208 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), CS(2), GRHPR(2), HAO1(1), MDH1(2), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2) 13478748 26 26 26 6 3 3 3 13 4 0 0.349 0.999 1.000 209 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(3), MBTPS1(3), MBTPS2(1), SCAP(4), SREBF1(4), SREBF2(8) 11734006 25 25 25 6 2 4 5 6 8 0 0.453 1.000 1.000 210 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(6), ACO1(5), ACSS1(4), ACSS2(7), FH(2), IDH1(2), IDH2(6), MDH1(2), MDH2(1), SUCLA2(2) 13350534 37 31 33 9 1 6 3 11 15 1 0.556 1.000 1.000 211 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAPK14(1), MAPK3(3), NFKB1(2), PIK3CA(14), PIK3R1(5), RB1(4), RELA(6), SP1(2) 19684038 54 52 46 10 3 14 3 20 11 3 0.221 1.000 1.000 212 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(4), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), GLCE(5), HS2ST1(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(3), HS6ST3(1), NDST1(2), NDST2(4), NDST3(1), NDST4(7) 20326473 48 44 42 8 5 4 7 17 15 0 0.133 1.000 1.000 213 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(2), DLL1(1), FURIN(3), NOTCH1(12) 8454303 18 18 16 5 3 4 0 5 5 1 0.573 1.000 1.000 214 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), NFKBIA(2), PLCB1(4), PRKCA(2), RELA(6) 8271451 16 16 13 6 2 3 0 4 6 1 0.877 1.000 1.000 215 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), CRKL(1), DOCK1(3), ELK1(1), FOS(1), GAB1(2), GRB2(2), HGF(1), HRAS(1), ITGA1(8), ITGB1(7), JUN(2), MAP2K2(1), MAP4K1(5), MAPK3(3), MET(22), PAK1(3), PIK3CA(14), PIK3R1(5), PTEN(34), PTK2(3), PTK2B(3), PTPN11(2), PXN(3), RAF1(4), RAP1A(1), RASA1(7), SOS1(9), SRC(4), STAT3(3) 45046157 156 125 146 28 7 31 17 49 49 3 0.0324 1.000 1.000 216 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAD(1), BAK1(1), BAX(1), BCL10(1), BCL2L11(1), BID(2), CASP8AP2(7), CASP9(2), CES1(8) 11444024 27 27 25 7 1 2 4 9 11 0 0.658 1.000 1.000 217 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(2), IL4(1), IL4R(4), IRS1(5), JAK1(7), JAK3(4), RPS6KB1(2), SHC1(4), STAT6(5) 14280336 37 35 37 9 6 3 5 14 9 0 0.381 1.000 1.000 218 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(3), LPO(1), MPO(6), MTHFR(1), PRDX6(2), SHMT1(2), SHMT2(5), TPO(4) 11498705 27 26 27 6 2 3 6 10 6 0 0.379 1.000 1.000 219 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(9), ATM(20), BRCA1(9), CDKN1A(3), CHEK1(1), CHEK2(2), JUN(2), MRE11A(3), NFKB1(2), NFKBIA(2), RAD50(4), RAD51(2), RBBP8(2), RELA(6), TP53(50), TP73(4) 29563356 121 97 108 23 13 15 12 41 35 5 0.0634 1.000 1.000 220 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(13) 16460708 35 32 33 5 3 1 2 14 15 0 0.337 1.000 1.000 221 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(5), DPYS(4), ENPP1(4), ENPP3(2), PANK1(2), PANK2(5), PANK3(3), PANK4(1), PPCS(1), UPB1(2) 13783530 32 30 32 8 3 3 4 13 9 0 0.493 1.000 1.000 222 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(1), CDC25B(1), CDC25C(3), CSK(4), GRB2(2), PRKCA(2), PTPRA(5), SRC(4) 9194770 23 21 23 6 0 8 4 8 3 0 0.353 1.000 1.000 223 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR161(2), GPR171(1), GPR18(2), GPR39(2), GPR45(3), GPR65(5), GPR75(1) 9703900 17 17 17 5 3 4 0 7 2 1 0.309 1.000 1.000 224 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(3), PRKCA(2) 4863301 5 5 5 3 0 1 0 2 2 0 0.962 1.000 1.000 225 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(3), AKT2(5), AKT3(3), BAD(1), GRB2(2), GSK3A(3), GSK3B(3), IL4R(4), IRS1(5), JAK1(7), JAK3(4), MAP4K1(5), MAPK3(3), PDK1(1), PIK3CA(14), PIK3CD(2), PIK3R1(5), PPP1R13B(4), RAF1(4), SHC1(4), SOS1(9), SOS2(7), STAT6(5) 35073374 103 88 96 18 12 18 19 35 19 0 0.00884 1.000 1.000 226 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15B(3), ALOX5(4), DPEP1(1), GGT1(4), LTA4H(4), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4) 15047940 37 34 34 9 4 5 9 10 8 1 0.314 1.000 1.000 227 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(2), PSMB10(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1) 8538360 17 17 17 5 1 1 1 8 6 0 0.804 1.000 1.000 228 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(3), PAPSS2(4), SULT1E1(2), SULT2A1(1), SUOX(4) 6145351 14 14 14 5 1 2 5 3 3 0 0.674 1.000 1.000 229 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT1(1), B4GALT3(2), B4GALT5(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2) 7686861 14 14 13 8 2 0 2 4 6 0 0.973 1.000 1.000 230 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(3), HLA-DRA(1), HLA-DRB1(6), IFNGR1(3), IFNGR2(2), IL12RB1(4), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(4) 12513657 30 28 30 9 5 4 2 11 8 0 0.585 1.000 1.000 231 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(6), CS(2), MDH1(2), ME1(1), PC(8), PDHA1(1), SLC25A1(1), SLC25A11(1) 9156149 22 21 22 9 1 3 1 10 7 0 0.885 1.000 1.000 232 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(2), CD3E(2), CD3G(2), CD4(10), IL12RB1(4), IL12RB2(2), JAK2(7), STAT4(2), TYK2(7) 14775786 39 36 32 8 3 2 6 12 15 1 0.609 1.000 1.000 233 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3) 16429456 22 21 18 3 1 2 4 7 8 0 0.331 1.000 1.000 234 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(3), CSNK1A1(2), GSK3B(3), MAPT(4), PPP2CA(1) 9382975 14 13 12 8 0 1 2 2 9 0 0.987 1.000 1.000 235 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CTH(2), GGT1(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), PAPSS1(3), PAPSS2(4), SCLY(3), SEPHS1(1) 12160401 31 30 31 9 3 5 8 8 7 0 0.474 1.000 1.000 236 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(1), ACP5(2), ACP6(3), ENPP1(4), ENPP3(2), FLAD1(4), MTMR1(2), MTMR2(3), MTMR6(1), PHPT1(1), TYR(5) 15026149 29 28 28 6 0 6 1 18 4 0 0.391 1.000 1.000 237 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 15207527 33 31 33 8 2 4 8 12 6 1 0.406 1.000 1.000 238 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 15207527 33 31 33 8 2 4 8 12 6 1 0.406 1.000 1.000 239 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 15207527 33 31 33 8 2 4 8 12 6 1 0.406 1.000 1.000 240 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(3), CLOCK(4), CRY1(1), CSNK1E(3), PER1(6) 8447097 17 17 16 5 2 1 4 5 4 1 0.658 1.000 1.000 241 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(5), AOC2(5), AOC3(2), CES1(8), DDHD1(2), ESCO1(2), ESCO2(1), LIPA(1), MYST3(4), MYST4(3), PLA1A(3), PNPLA3(3), PRDX6(2), SH3GLB1(3) 25070993 45 40 43 6 2 5 7 18 13 0 0.0870 1.000 1.000 242 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(3), NR3C1(4), PPARG(2), RETN(1), TNF(1) 5591626 11 11 11 5 1 3 2 3 2 0 0.812 1.000 1.000 243 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(3), BIRC3(5), CASP10(4), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), PRF1(1), SCAP(4), SREBF1(4), SREBF2(8) 17987606 38 37 38 8 1 7 7 13 10 0 0.277 1.000 1.000 244 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCR(2), CRKL(1), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAP3K1(8), MAPK3(3), MYC(2), PIK3CA(14), PIK3R1(5), RAF1(4), SOS1(9), STAT1(6), STAT5A(3), STAT5B(3) 27642790 76 70 70 14 5 14 9 33 15 0 0.0916 1.000 1.000 245 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), IL4(1), JUNB(3), MAF(2), MAP2K3(4), MAPK14(1), NFATC1(4), NFATC2(8), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3) 11365863 39 37 37 11 8 0 2 19 10 0 0.587 1.000 1.000 246 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(4), PRKCA(2), PTK2B(3) 6689394 11 11 10 7 1 3 1 2 4 0 0.973 1.000 1.000 247 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(3), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), STAT1(6), STAT3(3), STAT5A(3), STAT5B(3), THPO(1) 29869878 84 74 77 15 7 16 10 31 20 0 0.0888 1.000 1.000 248 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(3), CAMK1G(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), ESRRA(1), HDAC5(3), MEF2A(3), MEF2D(1), PPP3CA(3), PPP3CC(3), SLC2A4(3), SYT1(1) 20534709 34 34 33 5 4 2 4 13 11 0 0.150 1.000 1.000 249 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(3), NR1H3(3), NR1H4(2) 5216943 8 8 8 5 0 3 0 4 1 0 0.886 1.000 1.000 250 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), GRB2(2), HRAS(1), MAPK3(3), MAPK7(4), MEF2A(3), MEF2D(1), NTRK1(8), PIK3CA(14), PIK3R1(5), PLCG1(4), RPS6KA1(8), SHC1(4) 19052878 60 55 47 13 6 11 7 23 12 1 0.245 1.000 1.000 251 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(4), AGT(4), AGTR2(1), EDNRB(3), EGF(5), EGFR(10), FOS(1), HRAS(1), JUN(2), MYC(2), NFKB1(2), PLCG1(4), PRKCA(2), RELA(6) 20353047 47 41 41 9 5 5 5 18 13 1 0.325 1.000 1.000 252 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(1), B3GALT5(3), FUT1(1), FUT2(2), GBGT1(2), GLA(1), HEXA(4), ST3GAL1(2), ST8SIA1(2) 10462880 18 17 18 5 5 3 2 7 1 0 0.337 1.000 1.000 253 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(2), ADRB2(2), CFTR(9), GNAS(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SLC9A3R1(1) 12776536 33 33 33 9 4 2 2 17 8 0 0.725 1.000 1.000 254 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(7), JUN(2), MAP3K1(8), MAPK3(3), PDGFRA(8), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SRF(1), STAT1(6), STAT3(3), STAT5A(3) 34875916 98 86 91 17 9 19 8 35 27 0 0.0550 1.000 1.000 255 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), ATIC(2), FTCD(2), GART(4), MTFMT(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(1), SHMT1(2), SHMT2(5), TYMS(1) 19046794 36 35 36 8 3 6 3 18 6 0 0.360 1.000 1.000 256 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(1), CHST12(2), PAPSS1(3), PAPSS2(4), SULT1A1(2), SULT1E1(2), SULT2A1(1), SUOX(4) 8895794 19 19 18 6 3 3 5 3 5 0 0.633 1.000 1.000 257 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(3), AKT2(5), AKT3(3), BRAF(4), DDIT4(1), EIF4B(5), EIF4EBP1(1), FIGF(2), HIF1A(4), INS(1), MAPK3(3), PGF(2), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PRKAA1(1), PRKAA2(4), RHEB(5), RICTOR(7), RPS6KA1(8), RPS6KA3(3), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), STK11(3), TSC1(6), TSC2(13), ULK1(2), ULK2(3), ULK3(3), VEGFC(2) 52905862 136 123 117 23 13 25 19 45 29 5 0.00475 1.000 1.000 258 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAP3K14(2), MAPK14(1), NFKB1(2), RELA(6), TNFRSF13B(1), TNFRSF17(1), TNFSF13(1), TRAF2(1), TRAF3(1), TRAF5(5), TRAF6(2) 14523652 25 24 22 5 0 6 0 8 10 1 0.590 1.000 1.000 259 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(8), C5(6), C6(3), C7(4), ICAM1(3), ITGA4(3), ITGAL(7), ITGB1(7), ITGB2(2), SELP(2), SELPLG(3), TNF(1), VCAM1(6) 24821920 55 51 55 11 6 7 8 25 9 0 0.164 1.000 1.000 260 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(10), ELK1(1), GNAS(5), GNB1(3), GRB2(2), HRAS(1), IGF1R(3), ITGB1(7), KLK2(1), MAP2K2(1), MAPK3(3), MKNK1(2), MKNK2(1), MYC(2), NGFR(1), PDGFRA(8), PPP2CA(1), PTPRR(5), RAF1(4), RPS6KA1(8), RPS6KA5(2), SHC1(4), SOS1(9), SRC(4), STAT3(3) 32793720 92 78 85 18 9 14 9 36 23 1 0.142 1.000 1.000 261 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR2(2), CCR3(2), CCR5(1), CCR7(1), CD28(1), CD4(10), CXCR4(1), IFNGR1(3), IFNGR2(2), IL12RB1(4), IL12RB2(2), IL18R1(1), IL4(1), IL4R(4), TGFB2(3), TGFB3(1) 20042506 40 38 34 8 5 2 4 15 13 1 0.389 1.000 1.000 262 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(5), ADORA2B(1), ADORA3(2), P2RY1(3), P2RY2(2), P2RY6(2) 5565472 15 14 15 6 3 2 2 7 1 0 0.580 1.000 1.000 263 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(1), ACP5(2), ENPP1(4), ENPP3(2), FLAD1(4), TYR(5) 9661735 19 18 19 5 0 4 0 11 4 0 0.646 1.000 1.000 264 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(2), CYP11B1(3), CYP11B2(2), CYP17A1(3), CYP21A2(2), HSD11B2(1), HSD3B1(1) 9088362 15 14 15 7 1 0 2 8 4 0 0.838 1.000 1.000 265 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(2), CYP11B1(3), CYP11B2(2), CYP17A1(3), CYP21A2(2), HSD11B2(1), HSD3B1(1) 9088362 15 14 15 7 1 0 2 8 4 0 0.838 1.000 1.000 266 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(3), ELK1(1), EPOR(3), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PLCG1(4), PTPN6(3), RAF1(4), SHC1(4), SOS1(9), STAT5A(3), STAT5B(3) 21357045 53 50 51 10 4 6 11 19 13 0 0.194 1.000 1.000 267 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), PARK2(2), SNCAIP(4), UBE2E2(1), UBE2L3(1) 6336035 11 11 11 5 1 4 1 3 2 0 0.749 1.000 1.000 268 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(8), CD44(3), IL1B(1), IL6R(2), SELL(2), SPN(1), TGFB2(3), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF8(2) 13133143 25 24 23 6 2 7 3 5 8 0 0.371 1.000 1.000 269 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACOT11(2), ACYP1(1), DHRS2(1), DHRSX(5), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(1), FN3K(1), GCDH(3), HADHA(4), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3), YOD1(2) 25781060 45 41 38 6 2 5 8 13 17 0 0.138 1.000 1.000 270 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(2), HMGCS2(1), OXCT1(2) 7281201 9 9 9 4 0 2 1 5 1 0 0.859 1.000 1.000 271 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(6), CARS2(3), CTH(2), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(2), LDHC(3), MPST(2), SULT1B1(2), SULT1C2(1), SULT1C4(3), SULT4A1(1) 12512961 31 31 29 8 2 1 5 12 11 0 0.760 1.000 1.000 272 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(2), ARPC1B(2), ARPC2(9), NCK1(1), NCKAP1(3), NTRK1(8), PIR(1), PSMA7(1), RAC1(1), WASF1(1), WASF2(2), WASF3(3), WASL(7) 15201316 42 38 35 10 2 7 2 20 11 0 0.415 1.000 1.000 273 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BAD(1), BRAF(4), CREB3(2), CREB5(3), DUSP4(1), DUSP6(2), DUSP9(2), EEF2K(4), EIF4E(2), GRB2(2), MAP2K2(1), MAP3K8(1), MAPK3(3), MKNK1(2), MKNK2(1), MOS(1), NFKB1(2), RAP1A(1), RPS6KA1(8), RPS6KA3(3), SHC1(4), SOS1(9), SOS2(7), TRAF3(1) 29505379 69 64 64 13 7 11 15 21 13 2 0.0684 1.000 1.000 274 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), FDXR(2), SHMT1(2) 16061007 35 33 35 9 2 4 8 14 6 1 0.449 1.000 1.000 275 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), NAT1(1), NAT2(2), XDH(7) 7901121 25 24 25 8 4 3 4 10 4 0 0.648 1.000 1.000 276 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3) 7932985 17 17 15 6 1 2 4 6 4 0 0.821 1.000 1.000 277 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3) 7932985 17 17 15 6 1 2 4 6 4 0 0.821 1.000 1.000 278 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(2), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GPX1(2), PRKCE(4) 7712784 15 15 15 9 0 1 3 9 2 0 0.978 1.000 1.000 279 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(6), ARHGDIB(1), CASP1(3), CASP10(4), CASP8(1), CASP9(2), JUN(2), PRF1(1) 12699345 23 22 23 6 0 4 2 9 8 0 0.710 1.000 1.000 280 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(3), B3GNT7(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), CHST1(2), CHST2(2), CHST4(1), CHST6(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2) 11591238 26 25 25 9 4 4 2 6 10 0 0.749 1.000 1.000 281 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3E(2), CD3G(2), CD4(10), CREBBP(10), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTPRC(8), ZAP70(1) 22322459 69 60 63 15 6 10 5 28 19 1 0.357 1.000 1.000 282 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3E(2), CD3G(2), CD4(10), CREBBP(10), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTPRC(8), ZAP70(1) 22322459 69 60 63 15 6 10 5 28 19 1 0.357 1.000 1.000 283 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(2), ST3GAL4(2), ST3GAL5(1), ST6GALNAC2(3), ST8SIA1(2) 5420228 11 11 11 6 1 2 1 6 1 0 0.798 1.000 1.000 284 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(2), HS3ST3A1(1), XYLT1(5), XYLT2(2) 6037936 11 11 11 7 3 3 0 4 1 0 0.806 1.000 1.000 285 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(2), HS3ST3A1(1), XYLT1(5), XYLT2(2) 6037936 11 11 11 7 3 3 0 4 1 0 0.806 1.000 1.000 286 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ABAT(1), ADSL(3), AGXT(2), AGXT2(2), ASL(4), ASNS(2), ASPA(1), CAD(13), CRAT(3), DARS(3), DDO(1), GAD1(2), GAD2(2), GOT1(3), GOT2(2), GPT(4), GPT2(2), PC(8) 25927610 61 54 57 11 2 7 11 14 26 1 0.232 1.000 1.000 287 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ANKRD1(1), ATF3(1), EIF4E(2), EIF4EBP1(1), IFRD1(1), IL1R1(3), NR4A3(2), WDR1(2) 10856714 17 17 17 5 1 4 4 5 3 0 0.570 1.000 1.000 288 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(2), FUCA2(1), GLB1(5), HEXA(4), LCT(7), MAN2C1(5), MANBA(2), NEU1(1) 16037207 28 27 28 7 4 4 3 13 4 0 0.432 1.000 1.000 289 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), RPN1(3), RPN2(1), UBE2A(2), UBE3A(2) 13232474 24 24 24 7 1 2 2 11 8 0 0.756 1.000 1.000 290 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(2), CREM(1), FHL5(3), FSHR(2), GNAS(5), XPO1(8) 9349842 21 21 21 6 5 1 4 7 4 0 0.676 1.000 1.000 291 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(5), CS(2), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(3), IDH3G(2), MDH1(2), MDH2(1), PC(8), PCK1(5), SDHA(9), SDHB(1), SUCLA2(2), SUCLG1(5), SUCLG2(2) 20569521 61 54 58 15 3 10 7 22 18 1 0.368 1.000 1.000 292 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(3), LCMT1(1), LCMT2(4), METTL2B(1), PCYT1A(1), PCYT1B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3) 13882855 25 23 25 6 1 2 4 9 9 0 0.580 1.000 1.000 293 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(3), BFAR(2), BRAF(4), CAMP(1), CREB3(2), CREB5(3), RAF1(4), SNX13(4), SRC(4) 11545453 27 23 27 8 2 6 6 9 3 1 0.534 1.000 1.000 294 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK3(3), MYC(2), NFKB1(2), NFKBIA(2), PLCB1(4), PRKCA(2), RAF1(4), RELA(6), TNF(1) 15171285 32 31 29 8 6 3 2 11 9 1 0.561 1.000 1.000 295 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2AK4(6), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF5(3), GSK3B(3), PPP1CA(1) 11555478 22 21 20 8 2 1 5 6 8 0 0.816 1.000 1.000 296 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(1), JUN(2), KEAP1(3), MAPK14(1), NFE2L2(11), PRKCA(2) 8751422 20 20 18 8 1 3 3 10 3 0 0.808 1.000 1.000 297 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(5), GNB1(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2) 9484817 27 26 27 8 4 3 0 15 5 0 0.723 1.000 1.000 298 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(1), DHRSX(5), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3) 14720858 26 24 22 5 1 2 5 6 12 0 0.479 1.000 1.000 299 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), ASPA(1), CNDP1(5), DDC(3), HAL(1), HARS(1), HDC(1), HNMT(2), MAOA(2), MAOB(2), PRPS1(1), PRPS2(4) 24203280 59 55 56 13 6 10 10 22 11 0 0.153 1.000 1.000 300 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(2), IFNB1(3), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL1RN(1), IRAK1(3), IRAK3(4), JUN(2), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAP3K14(2), MAP3K7(3), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TGFB2(3), TGFB3(1), TNF(1), TRAF6(2) 29600469 64 58 60 11 8 15 1 21 17 2 0.0982 1.000 1.000 301 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(2), EPHB1(4), FYN(2), ITGA1(8), ITGB1(7), L1CAM(5), LYN(1), SELP(2) 15696413 32 30 30 9 4 5 2 13 8 0 0.621 1.000 1.000 302 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(5), ACADM(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(2), CNDP1(5), DPYD(5), DPYS(4), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), HIBCH(1), MLYCD(3), SMS(2), UPB1(2) 26665905 69 63 66 16 4 9 17 21 17 1 0.191 1.000 1.000 303 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(10), APOBEC1(2), APOBEC3B(1), APOBEC3G(1), APOBEC4(1) 7316523 15 14 15 8 3 0 5 6 1 0 0.913 1.000 1.000 304 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(20), BMPR1B(2), CCND2(1), CDK4(6), CDKN1B(1), DAZL(3), EGR1(10), ESR2(4), FSHR(2), GJA4(1), MLH1(3), NCOR1(7), NR5A1(1), NRIP1(7), PGR(5), PRLR(3), PTGER2(1), SMPD1(6), VDR(2), ZP2(6) 34185059 91 78 79 17 10 11 10 29 30 1 0.0991 1.000 1.000 305 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(2), ADRB2(2), GNAS(5), PLCE1(6), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RAP2B(2) 14475925 31 31 31 9 4 3 3 13 8 0 0.693 1.000 1.000 306 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1R(3), IRS1(5), JUN(2), MAPK3(3), PIK3CA(14), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SRF(1) 24204700 67 62 62 15 9 18 5 23 12 0 0.125 1.000 1.000 307 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CFL1(1), CHN1(2), LIMK1(7), MAP3K1(8), MYL2(1), MYLK(4), NCF2(1), PAK1(3), PDGFRA(8), PIK3CA(14), PIK3R1(5), PLD1(3), PPP1R12B(2), RAC1(1), RALBP1(2), RPS6KB1(2), TRIO(9), VAV1(4), WASF1(1) 35067461 79 73 71 14 4 13 7 30 25 0 0.127 1.000 1.000 308 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(2), IKBKAP(2), IKBKB(3), IKBKG(1), MAP3K1(8), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6), TNFAIP3(2), TRAF3(1), TRAF6(2) 18573647 33 31 30 7 2 8 0 9 13 1 0.499 1.000 1.000 309 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(2), FUCA2(1), GLB1(5), HEXA(4), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(5), MANBA(2), NEU1(1) 19751506 31 29 31 7 5 4 4 14 4 0 0.299 1.000 1.000 310 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(7), FYN(2), LRP8(4), RELN(7), VLDLR(4) 14040613 24 23 19 7 2 5 0 6 11 0 0.905 1.000 1.000 311 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(2), APC(9), AXIN1(5), BTRC(2), CTNNB1(2), DLL1(1), DVL1(1), FZD1(4), GSK3B(3), NOTCH1(12), WNT1(2) 20334446 43 41 40 10 6 6 3 17 10 1 0.364 1.000 1.000 312 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(3), CASP9(2), DAXX(6), FAS(2), FASLG(3), HSPB2(2), MAPKAPK2(1), TNF(1) 10996543 21 19 21 6 2 5 2 7 5 0 0.599 1.000 1.000 313 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(9), CDH1(2), CREBBP(10), EP300(16), MAP3K7(3), MAPK3(3), SKIL(2), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2) 25692930 52 48 49 10 3 6 10 20 12 1 0.140 1.000 1.000 314 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), AARS2(3), ABAT(1), ACY3(1), ADSL(3), ADSSL1(2), AGXT(2), AGXT2(2), ASL(4), ASNS(2), ASPA(1), ASRGL1(4), ASS1(3), CAD(13), CRAT(3), DARS(3), DARS2(1), DDO(1), DLAT(2), DLD(4), GAD1(2), GAD2(2), GOT1(3), GOT2(2), GPT(4), GPT2(2), NARS2(6), PC(8), PDHA1(1), PDHA2(3), PDHB(1) 37685397 92 74 85 16 5 10 15 25 35 2 0.0798 1.000 1.000 315 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(3), APC(9), AR(5), ASAH1(3), BRAF(4), CAMP(1), DAG1(3), EGFR(10), GNA11(1), GNA15(1), GNAI1(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), KCNJ3(4), MAPK10(2), MAPK14(1), PHKA2(5), PIK3CA(14), PIK3CD(2), PIK3R1(5), PITX2(2), RAF1(4), SRC(4) 53265732 114 94 106 18 10 25 19 40 19 1 0.00249 1.000 1.000 316 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(2), IFNB1(3), IL15(1), IL16(5), IL3(1), IL4(1), IL9(1), LTA(1), TNF(1) 9777111 16 16 16 6 0 7 2 6 1 0 0.619 1.000 1.000 317 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), DPM2(1), GRB2(2), HRAS(1), KLK2(1), NTRK1(8), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), SHC1(4), SOS1(9) 15437433 54 49 47 13 3 14 5 22 10 0 0.312 1.000 1.000 318 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), CYP2C19(1), CYP2C9(1), DHRS2(1), DHRSX(5), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(1), HADHA(4), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3), YOD1(2) 30758903 57 52 50 10 3 7 11 17 19 0 0.170 1.000 1.000 319 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(20), ATR(12), BRCA1(9), BRCA2(14), CHEK1(1), CHEK2(2), FANCA(5), FANCD2(1), FANCE(2), FANCF(2), FANCG(4), HUS1(2), MRE11A(3), RAD17(2), RAD50(4), RAD51(2), TP53(50), TREX1(3) 44391929 138 109 128 24 11 21 17 52 34 3 0.0159 1.000 1.000 320 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(3), GLI2(4), GLI3(7), GSK3B(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SHH(3), SMO(4), SUFU(3) 15784321 44 39 41 12 5 5 3 17 14 0 0.596 1.000 1.000 321 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), BAD(1), GRB2(2), HRAS(1), IGF1R(3), IRS1(5), MAPK3(3), PIK3CA(14), PIK3R1(5), RAF1(4), SHC1(4), SOS1(9) 18497862 54 49 49 13 7 13 6 20 8 0 0.182 1.000 1.000 322 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(6), ARHGEF1(2), GNA12(1), GNA13(4), GNB1(3), MYL2(1), MYLK(4), PLCB1(4), PPP1R12B(2), PRKCA(2), ROCK1(5) 20532945 34 34 34 8 3 2 2 19 8 0 0.513 1.000 1.000 323 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(2), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H2(2), GTF2H4(1), GTF2I(4), GTF2IRD1(2), STON1(3), TAF1(8), TAF10(1), TAF13(1), TAF1L(10), TAF2(6), TAF4(7), TAF4B(8), TAF5(2), TAF5L(3), TAF6(2), TAF7(2), TAF7L(7), TAF9B(2), TBPL2(1) 36296949 84 75 80 16 5 13 13 33 20 0 0.0493 1.000 1.000 324 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), DCXR(1), GUSB(7), RPE(2), UGDH(1), UGP2(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), XYLB(2) 27074632 63 57 61 14 5 7 15 19 17 0 0.264 1.000 1.000 325 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(10), G6PD(2), GCLC(4), GGT1(4), GPX1(2), GPX3(3), GPX4(2), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTM1(3), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), IDH1(2), IDH2(6) 18274417 50 45 47 12 4 6 11 19 10 0 0.376 1.000 1.000 326 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(5), ALDH1A3(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), DDC(3), EPX(3), GOT1(3), GOT2(2), HPD(2), LPO(1), MAOA(2), MAOB(2), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), TAT(2), TPO(4) 21679052 58 51 55 14 8 6 14 16 14 0 0.295 1.000 1.000 327 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(3), ACADL(3), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), AOX1(8), BCAT1(1), BCKDHA(2), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4), HIBADH(1), HMGCL(1), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(3) 36204338 78 75 74 16 5 12 16 29 15 1 0.117 1.000 1.000 328 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(2), DLAT(2), DLD(4), FH(2), IDH2(6), IDH3B(3), IDH3G(2), MDH1(2), MDH2(1), OGDH(8), PC(8), PDHA1(1), PDHA2(3), PDHB(1), PDHX(2), PDK1(1), PDK2(3), PDK3(2), PDK4(1), PDP2(2), SDHA(9), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(5), SUCLG2(2) 28412255 77 65 74 18 3 15 9 26 23 1 0.242 1.000 1.000 329 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(5), IMPA1(1), PGM1(1) 10177273 9 8 9 7 3 0 0 4 2 0 0.963 1.000 1.000 330 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(2), AKT1(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(5), GRB2(2), HRAS(1), MAPK14(1), MAPK3(3), PIK3CA(14), PIK3R1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), RAC1(1), RPS6KA1(8), RPS6KA5(2), SOS1(9) 28942909 78 74 68 17 7 15 6 34 15 1 0.230 1.000 1.000 331 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(3), ACADL(3), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ACOX1(2), ACOX3(5), ACSL1(4), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), CPT1A(2), CPT1C(4), CPT2(2), CYP4A11(5), CYP4A22(2), ECHS1(3), EHHADH(6), GCDH(3), HADH(1), HADHA(4), HADHB(4), HSD17B4(2), PECI(1) 49080635 110 95 91 22 7 14 18 47 23 1 0.0747 1.000 1.000 332 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(1), FUT2(2), GBGT1(2), GLA(1), HEXA(4), ST3GAL1(2), ST3GAL4(2), ST8SIA1(2) 9864830 16 16 16 7 3 2 1 8 2 0 0.735 1.000 1.000 333 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(9), AXIN1(5), BTRC(2), CREBBP(10), CSNK1A1(2), CSNK2A1(3), CTBP1(2), CTNNB1(2), DVL1(1), FZD1(4), GSK3B(3), HDAC1(2), MAP3K7(3), MYC(2), NLK(1), PPARD(1), PPP2CA(1), TLE1(6), WIF1(5), WNT1(2) 29096292 66 57 60 14 7 6 7 23 22 1 0.231 1.000 1.000 334 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(2), CAD(13), CPS1(6), EPRS(5), GAD1(2), GAD2(2), GCLC(4), GFPT1(3), GLS(7), GLS2(4), GLUL(2), GMPS(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), GSS(1), NADSYN1(1), PPAT(3), QARS(1) 33229940 69 60 65 13 5 9 12 25 17 1 0.162 1.000 1.000 335 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(3), CALCRL(2), CD97(6), CRHR1(2), CRHR2(3), ELTD1(4), EMR1(2), EMR2(4), GIPR(2), GLP1R(3), GLP2R(3), GPR64(3), LPHN1(5), LPHN2(4), LPHN3(10), SCTR(1), VIPR1(1), VIPR2(2) 27394928 62 54 61 14 11 7 10 24 10 0 0.156 1.000 1.000 336 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(5), CHIT1(5), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(3), GFPT2(1), GNE(1), GNPDA1(1), GNPNAT1(1), HEXA(4), HK1(5), MTMR1(2), MTMR2(3), MTMR6(1), NAGK(3), NANS(3), NPL(6), PHPT1(1), RENBP(4) 28703491 58 56 55 11 8 6 8 20 15 1 0.0795 1.000 1.000 337 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(5), AKT3(3), CISH(2), GRB2(2), IARS(4), IL13RA1(2), IL4(1), IL4R(4), INPP5D(2), JAK1(7), JAK2(7), JAK3(4), PI3(1), PIK3CA(14), PPP1R13B(4), RPS6KB1(2), SHC1(4), SOS1(9), SOS2(7), SRC(4), STAT6(5), TYK2(7) 36548116 103 85 97 21 7 20 18 37 21 0 0.0512 1.000 1.000 338 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(6), JAK1(7), JAK2(7), JAK3(4), JUN(2), MAPK3(3), PTPN11(2), RAF1(4), SHC1(4), SOS1(9), SRF(1), STAT3(3) 23498579 62 58 62 15 5 7 10 26 14 0 0.395 1.000 1.000 339 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(9), AXIN1(5), CREBBP(10), CTNNB1(2), DVL1(1), EP300(16), FZD1(4), GSK3B(3), HDAC1(2), LDB1(2), LEF1(3), PITX2(2), TRRAP(12), WNT1(2) 32696619 73 64 64 15 6 5 10 29 23 0 0.256 1.000 1.000 340 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(5), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5) 10376815 19 19 18 8 3 4 2 8 2 0 0.677 1.000 1.000 341 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(10), ABCC2(4), ABCG2(2), BCHE(3), CES1(8), CES2(2), CYP3A5(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5) 22967930 51 43 46 13 3 5 10 15 18 0 0.593 1.000 1.000 342 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(5), IMPA1(1), IMPA2(3), PGM1(1) 11508127 12 11 12 8 4 0 0 5 3 0 0.962 1.000 1.000 343 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLB(2), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLG(6), POLG2(5), POLH(5), POLI(3), POLK(5), POLL(2), POLM(4), POLQ(13), PRIM1(3), PRIM2(7), REV1(5), REV3L(17), RFC5(3) 41235141 98 83 92 18 5 8 7 46 32 0 0.294 1.000 1.000 344 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), JAK1(7), JAK3(4), JUN(2), LCK(1), MAPK3(3), RAF1(4), SHC1(4), SOS1(9), STAT5A(3), STAT5B(3), SYK(2) 23192421 54 52 53 13 7 7 9 18 13 0 0.323 1.000 1.000 345 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(4), ALDH18A1(1), ARG1(1), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(6), GATM(2), NAGS(1), OAT(2), ODC1(2), OTC(1), PYCR1(1), SMS(2) 17506301 30 29 30 9 1 2 5 14 8 0 0.815 1.000 1.000 346 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(3), BAK1(1), BAX(1), BID(2), BIK(1), BIRC2(3), BIRC3(5), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), DIABLO(1) 13557694 23 23 23 8 1 4 5 8 5 0 0.707 1.000 1.000 347 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(5), ACADL(3), ACADM(1), ACADSB(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), AOC2(5), AOC3(2), CNDP1(5), DPYD(5), DPYS(4), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), MLYCD(3), SMS(2), UPB1(2) 28727325 73 67 70 19 4 11 17 23 16 2 0.286 1.000 1.000 348 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(2), ARHGEF1(2), F2(4), F2R(2), F2RL3(1), GNA12(1), GNA13(4), GNAI1(2), GNB1(3), MAP3K7(3), PIK3CA(14), PIK3R1(5), PLCB1(4), PPP1R12B(2), PRKCA(2), PTK2B(3), ROCK1(5) 25627043 59 56 54 13 8 12 5 22 11 1 0.156 1.000 1.000 349 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(2), IKBKAP(2), IKBKB(3), IKBKG(1), LTA(1), MAP3K1(8), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TANK(1), TNFAIP3(2), TNFRSF1B(1), TRAF2(1), TRAF3(1) 22639343 36 33 33 9 3 8 0 11 13 1 0.589 1.000 1.000 350 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(2), CAP1(3), CCNB1(1), CDC25C(3), GNAI1(2), GNAS(5), GNB1(3), HRAS(1), MAPK3(3), MYT1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RPS6KA1(8), SRC(4) 20081799 55 51 50 14 7 8 4 24 11 1 0.448 1.000 1.000 351 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), CHUK(2), IKBKB(3), IL4(1), JUN(2), MAP3K1(8), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TNFRSF9(1), TNFSF9(1), TRAF2(1) 19715506 41 37 38 10 2 5 1 18 14 1 0.757 1.000 1.000 352 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(5), AGXT(2), AGXT2(2), AKR1B10(3), ALAS1(5), ALAS2(5), AOC2(5), AOC3(2), BHMT(7), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(5), GATM(2), GLDC(4), GNMT(2), MAOA(2), MAOB(2), PHGDH(3), PIPOX(3), PISD(2), PSAT1(2), RDH11(4), RDH13(1), SARDH(5), SARS(3), SARS2(1), SHMT1(2), SHMT2(5), TARS(6), TARS2(7) 42587499 110 98 106 24 13 18 18 37 23 1 0.0623 1.000 1.000 353 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA1(3), ACADM(1), ACADS(3), ACAT1(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), AOX1(8), BCAT1(1), BCKDHA(2), DBT(2), DLD(4), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HADHB(4), HIBADH(1), HIBCH(1), HMGCL(1), HMGCS1(2), HMGCS2(1), HSD17B4(2), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(3) 43391069 87 83 83 17 6 11 22 31 16 1 0.0584 1.000 1.000 354 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(6), DIAPH1(7), FYN(2), GSN(5), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), MYL2(1), MYLK(4), PIK3CA(14), PIK3R1(5), PTK2(3), PXN(3), RAF1(4), ROCK1(5), SHC1(4), SRC(4), TLN1(14) 37368121 100 89 94 21 7 18 11 36 28 0 0.178 1.000 1.000 355 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6R(2), JAK1(7), JAK2(7), JAK3(4), PIAS3(3), PTPRU(5), SRC(4), STAT3(3) 15110643 37 33 37 10 2 5 5 15 10 0 0.628 1.000 1.000 356 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(5), ALDH1A3(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), DDC(3), EPX(3), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), HPD(2), LPO(1), MAOA(2), MAOB(2), MPO(6), MYST3(4), MYST4(3), PNPLA3(3), PRDX6(2), SH3GLB1(3), TAT(2), TPO(4) 33768970 70 61 67 15 9 8 14 22 17 0 0.176 1.000 1.000 357 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(8), ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), ATP7A(5), ATP7B(8), COX10(5), COX5A(1), COX6A2(1), COX7A1(2), COX7A2(1), COX8A(1), NDUFA1(1), NDUFA10(2), NDUFA11(2), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(2), SDHA(9), SDHB(1), SHMT1(2), UQCRC1(1), UQCRFS1(2) 38390393 104 94 102 24 7 17 19 41 19 1 0.150 1.000 1.000 358 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CABIN1(11), CALM2(1), CAMK1(3), CAMK1G(3), HDAC5(3), IGF1R(3), INS(1), INSR(6), MAP2K6(1), MAPK14(1), MAPK7(4), MEF2A(3), MEF2D(1), NFATC1(4), NFATC2(8), PIK3CA(14), PIK3R1(5), PPP3CA(3), PPP3CC(3), SYT1(1) 34121501 82 75 71 19 11 14 7 28 22 0 0.203 1.000 1.000 359 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), CYB5R3(2), GCK(2), GFPT1(3), GNE(1), GNPDA1(1), HEXA(4), HK1(5), RENBP(4) 16947245 23 22 23 7 4 0 2 12 5 0 0.732 1.000 1.000 360 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GHR(1), GRB2(2), HRAS(1), INS(1), INSR(6), IRS1(5), JAK2(7), MAPK3(3), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), PTPN6(3), RAF1(4), RPS6KA1(8), SHC1(4), SLC2A4(3), SOS1(9), SRF(1), STAT5A(3), STAT5B(3) 32700934 89 78 75 20 7 15 15 29 22 1 0.246 1.000 1.000 361 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(13), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(4), DTYMK(1), ENTPD1(1), NT5M(2), POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(13), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLRMT(5), RRM1(3), RRM2(1), TK1(1), TK2(2), TXNRD1(2), TYMS(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(2), UPP1(2) 57025029 118 96 109 21 9 15 17 34 41 2 0.0522 1.000 1.000 362 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(5), DBH(2), DDC(3), GAD1(2), GAD2(2), HDC(1), MAOA(2), PAH(6), SLC18A3(2), TH(4), TPH1(2) 13885177 32 31 30 10 3 5 8 8 8 0 0.632 1.000 1.000 363 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), ARSB(1), FUCA1(2), FUCA2(1), GALNS(6), GBA(3), GLB1(5), GNS(4), GUSB(7), HEXA(4), HGSNAT(3), HPSE(3), HPSE2(4), HYAL1(2), HYAL2(1), IDS(2), IDUA(6), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(5), MANBA(2), NAGLU(2), NEU1(1), SPAM1(8) 33873228 83 69 78 19 13 10 11 37 12 0 0.113 1.000 1.000 364 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AGT(4), AKT1(3), CALM2(1), CALR(2), CAMK1(3), CAMK1G(3), CAMK4(3), CREBBP(10), CSNK1A1(2), ELSPBP1(2), F2(4), FGF2(1), GATA4(2), GSK3B(3), HAND2(1), HRAS(1), MAPK14(1), MAPK3(3), MYH2(9), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NKX2-5(3), NPPA(1), PIK3CA(14), PIK3R1(5), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RAF1(4), RPS6KB1(2), SYT1(1) 49735722 131 112 121 28 14 20 11 45 41 0 0.117 1.000 1.000 365 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), DAG1(3), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), NFAT5(10), PDE6A(1), PDE6B(6), PDE6C(3), SLC6A13(7) 35983094 65 59 64 13 6 7 14 27 11 0 0.0993 1.000 1.000 366 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(9), ATF2(2), AXIN1(5), BMP10(1), BMP2(2), BMP4(1), BMP5(1), BMP7(5), BMPR1A(1), BMPR2(5), CHRD(5), CTNNB1(2), DVL1(1), FZD1(4), GATA4(2), GSK3B(3), MAP3K7(3), MYL2(1), NKX2-5(3), NOG(2), NPPA(1), NPPB(1), RFC1(6), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TGFBR3(3), WNT1(2) 35696562 79 67 77 17 12 7 5 33 21 1 0.180 1.000 1.000 367 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(5), AKT3(3), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CSK(4), DAG1(3), EPHB2(2), GRB2(2), ITPKA(2), ITPKB(2), LYN(1), MAP2K2(1), NFAT5(10), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PI3(1), PIK3CA(14), PIK3CD(2), PIK3R1(5), PLCG2(4), PPP1R13B(4), RAF1(4), SHC1(4), SOS1(9), SOS2(7), SYK(2), VAV1(4) 51640144 115 98 109 21 12 21 18 43 21 0 0.0101 1.000 1.000 368 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(3), ALOX5(4), CBR1(4), CYP4F2(4), CYP4F3(2), EPX(3), GGT1(4), LPO(1), LTA4H(4), MPO(6), PLA2G4A(2), PLA2G6(5), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4), TPO(4) 27591028 66 61 63 16 8 6 19 19 13 1 0.276 1.000 1.000 369 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CTH(2), GGT1(4), LCMT1(1), LCMT2(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS1(3), PAPSS2(4), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SCLY(3), SEPHS1(1), SEPHS2(4) 24467737 55 51 55 14 4 7 15 15 14 0 0.332 1.000 1.000 370 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(3), CAT(2), GHR(1), HRAS(1), IGF1R(3), PIK3CA(14), PIK3R1(5), SHC1(4) 13024190 33 31 28 10 3 9 3 13 5 0 0.560 1.000 1.000 371 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(2), EPHB2(2), F2(4), F2RL1(1), F2RL2(2), F2RL3(1), JUN(2), MAP2K5(4), MAPK7(4), MYEF2(1), PLD1(3), PLD2(7), PLD3(3), PTK2(3), RAF1(4), RASAL1(8), SRC(4), TEC(6), VAV1(4) 27320060 66 61 59 16 9 7 8 26 16 0 0.386 1.000 1.000 372 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(10), EP300(16), IKBKB(3), IL1B(1), MAP2K3(4), MAP2K6(1), MAP3K14(2), MAP3K7(3), MAPK11(1), MAPK14(1), NFKB1(2), NFKBIA(2), NR3C1(4), RELA(6), TGFBR1(1), TGFBR2(2), TLR2(2), TNF(1) 29534966 64 54 58 14 5 9 7 20 21 2 0.345 1.000 1.000 373 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(8), ACE2(2), AGT(4), AGTR1(2), AGTR2(1), ANPEP(10), CMA1(1), CTSA(1), ENPEP(7), LNPEP(4), MAS1(1), MME(6), REN(1), THOP1(1) 21043556 49 43 44 14 2 6 13 18 10 0 0.672 1.000 1.000 374 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 82 AIFM1(6), AKT1(3), AKT2(5), AKT3(3), APAF1(3), ATM(20), BAD(1), BAX(1), BID(2), BIRC2(3), BIRC3(5), CAPN1(3), CAPN2(4), CASP10(4), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), CSF2RB(5), DFFA(1), DFFB(1), FAS(2), FASLG(3), IKBKB(3), IKBKG(1), IL1B(1), IL1R1(3), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(4), IRAK4(1), MAP3K14(2), NFKB1(2), NFKB2(3), NFKBIA(2), NTRK1(8), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RELA(6), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF1A(1), TNFSF10(9), TP53(50), TRADD(2), TRAF2(1) 83805472 255 195 231 42 25 36 32 95 63 4 0.000215 1.000 1.000 375 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22(1), IL22RA1(3), IL22RA2(1), JAK1(7), JAK2(7), JAK3(4), SOCS3(1), STAT1(6), STAT3(3), STAT5A(3), STAT5B(3), TYK2(7) 18363912 50 48 48 14 4 0 10 22 14 0 0.808 1.000 1.000 376 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(5), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), ALDH1A3(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), AOX1(8), DBH(2), DCT(4), DDC(3), FAH(1), GOT1(3), GOT2(2), HGD(3), HPD(2), MAOA(2), MAOB(2), TAT(2), TH(4), TPO(4), TYR(5) 31347067 80 71 76 22 11 7 9 32 21 0 0.579 1.000 1.000 377 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 GORASP1(1), IKBKG(1), MAP2K7(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MAPKAPK5(1), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PIK3CA(14), PIK3CD(2), PIK3R1(5), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(5), TRAF6(2) 33129081 64 59 59 14 10 13 6 25 10 0 0.106 1.000 1.000 378 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(2), CD3G(2), ETV5(3), IL12RB1(4), IL12RB2(2), IL18R1(1), JAK2(7), JUN(2), MAP2K6(1), MAPK14(1), STAT4(2), TYK2(7) 18708322 35 34 34 10 3 2 6 16 8 0 0.714 1.000 1.000 379 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(2), EGR2(1), EGR3(2), MAP3K1(8), MYC(2), NFATC1(4), NFATC2(8), NFKB1(2), NFKBIA(2), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RELA(6), SYT1(1), VIPR2(2) 27229521 65 60 59 17 8 6 1 23 26 1 0.694 1.000 1.000 380 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CHUK(2), CREBBP(10), EP300(16), IKBKB(3), IKBKG(1), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF6(2) 22330282 50 45 44 13 3 8 7 12 19 1 0.574 1.000 1.000 381 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(3), ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1B10(3), AKR1C4(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), BAAT(2), CEL(3), CYP27A1(1), HADHB(4), LIPA(1), RDH11(4), RDH13(1), SLC27A5(3), SOAT1(4), SOAT2(4), SRD5A1(1) 31685848 68 63 63 17 7 5 7 30 19 0 0.515 1.000 1.000 382 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ARHGAP1(1), ARHGAP5(6), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(3), ARPC1B(2), ARPC2(9), BAIAP2(2), CFL1(1), DIAPH1(7), GSN(5), LIMK1(7), MYL2(1), MYLK(4), OPHN1(2), PIP5K1A(2), PIP5K1B(1), PPP1R12B(2), ROCK1(5), SRC(4), TLN1(14), VCL(2) 45557010 91 79 81 17 4 10 9 30 38 0 0.196 1.000 1.000 383 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), G6PD(2), GPI(3), H6PD(3), PFKL(3), PFKM(3), PFKP(3), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(2), TALDO1(2), TKT(2), TKTL1(2), TKTL2(6) 23959576 50 49 48 14 6 8 6 16 14 0 0.536 1.000 1.000 384 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(10), EP300(16), FYN(2), IL7R(1), JAK1(7), JAK3(4), LCK(1), PIK3CA(14), PIK3R1(5), PTK2B(3), STAT5A(3), STAT5B(3) 27958379 69 63 60 17 4 14 12 21 18 0 0.332 1.000 1.000 385 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(1), ACP5(2), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CYP19A1(2), CYP1A1(1), CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(3), CYP3A5(1), CYP3A7(2), CYP4B1(4), CYP4F8(1), CYP51A1(2) 28654943 66 56 66 16 13 13 3 27 10 0 0.123 1.000 1.000 386 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(3), ALG5(2), B4GALT1(1), B4GALT3(2), B4GALT5(2), DPAGT1(8), DPM1(1), MAN1A1(2), MAN1B1(1), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), RPN1(3), RPN2(1), ST6GAL1(1) 19414258 37 35 37 10 2 9 1 13 12 0 0.446 1.000 1.000 387 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), BAX(1), CASP8(1), MAP3K1(8), MAPK3(3), NFKB1(2), NSMAF(7), RAF1(4), RELA(6), RIPK1(1), SMPD1(6), TNFRSF1A(1), TRADD(2), TRAF2(1) 20354567 44 40 40 12 4 7 6 13 13 1 0.522 1.000 1.000 388 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BAD(1), CBL(3), CFLAR(1), CRKL(1), E2F1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), IRS1(5), JAK1(7), JAK3(4), MAPK3(3), MYC(2), PIK3CA(14), PIK3R1(5), PPIA(1), PTPN6(3), RAF1(4), RPS6KB1(2), SHC1(4), SOCS3(1), SOS1(9), STAT5A(3), STAT5B(3), SYK(2) 35397378 90 82 84 21 9 18 15 28 20 0 0.145 1.000 1.000 389 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGAP3(2), ARFGEF2(8), CLTA(1), CLTB(2), COPA(6), GBF1(13), GPLD1(2), KDELR2(2), KDELR3(6) 16342389 44 42 44 13 2 2 7 19 12 2 0.801 1.000 1.000 390 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(10), EP300(16), LPL(3), NCOA1(4), NCOA2(11), PPARG(2) 18385145 46 37 37 14 4 6 5 12 19 0 0.654 1.000 1.000 391 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), CD3E(2), CD3G(2), ELK1(1), FOS(1), FYN(2), GRB2(2), HRAS(1), JUN(2), LAT(1), LCK(1), MAP3K1(8), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKBIA(2), PIK3CA(14), PIK3R1(5), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), PTPN7(1), RAC1(1), RAF1(4), RASA1(7), RELA(6), SHC1(4), SOS1(9), SYT1(1), VAV1(4), ZAP70(1) 47050549 122 106 111 27 12 26 10 38 35 1 0.196 1.000 1.000 392 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2A1(3), AP2M1(1), BIN1(6), CALM2(1), DNM1(4), EPN1(1), EPS15(3), PICALM(3), PPP3CA(3), PPP3CC(3), SYNJ1(6), SYNJ2(6), SYT1(1) 22148223 45 44 43 13 2 6 8 20 9 0 0.570 1.000 1.000 393 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(2), ATF2(2), CALM2(1), EGFR(10), ELK1(1), GRB2(2), HRAS(1), JUN(2), MAP2K2(1), MAP3K1(8), MAPK3(3), MEF2A(3), MEF2D(1), PAK1(3), PRKCA(2), PTK2(3), PTK2B(3), RAC1(1), RAF1(4), SHC1(4), SOS1(9), SRC(4), SYT1(1) 33840107 75 64 73 18 7 16 9 26 17 0 0.301 1.000 1.000 394 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(5), EGFR(10), MAP3K1(8), MAPK14(1), NCOR2(7), RARA(4), THRA(2) 17113989 37 33 35 11 2 5 7 10 13 0 0.756 1.000 1.000 395 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(3), CAPN2(4), EGF(5), EGFR(10), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), MYL2(1), MYLK(4), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTK2(3), PXN(3), TLN1(14) 32783740 81 72 78 20 9 7 7 36 22 0 0.485 1.000 1.000 396 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(8), BST1(2), CD38(1), ENPP1(4), ENPP3(2), NADK(1), NADSYN1(1), NMNAT2(2), NMNAT3(2), NNMT(1), NNT(7), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5M(2), NUDT12(2), QPRT(1) 21512856 42 40 41 12 3 3 4 24 8 0 0.657 1.000 1.000 397 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(5), ACY3(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDH7A1(1), AMDHD1(2), AOC2(5), AOC3(2), ASPA(1), CNDP1(5), DDC(3), FTCD(2), HAL(1), HARS(1), HARS2(1), HDC(1), HNMT(2), LCMT1(1), LCMT2(4), MAOA(2), MAOB(2), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), PRPS1(1), PRPS2(4), UROC1(2) 39158508 86 74 83 20 8 15 14 30 19 0 0.156 1.000 1.000 398 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(2), PGAP1(6), PIGB(2), PIGC(1), PIGF(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(3), PIGO(5), PIGP(1), PIGQ(6), PIGS(2), PIGT(6), PIGU(1), PIGV(1), PIGZ(3) 24309100 48 44 44 14 4 9 6 18 10 1 0.588 1.000 1.000 399 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(9), AXIN1(5), CTNNB1(2), DVL1(1), FZD1(4), GNAI1(2), GSK3B(3), IRAK1(3), LBP(1), LEF1(3), LY96(1), NFKB1(2), PIK3CA(14), PIK3R1(5), PPP2CA(1), RELA(6), TLR4(3), WNT1(2) 30077777 70 67 60 18 5 14 7 25 18 1 0.363 1.000 1.000 400 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(2), CDC42(1), DAXX(6), ELK1(1), GRB2(2), HRAS(1), HSPB2(2), MAP2K6(1), MAP3K1(8), MAP3K5(5), MAP3K7(3), MAP3K9(6), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MAX(5), MEF2A(3), MEF2D(1), MKNK1(2), MYC(2), PLA2G4A(2), RAC1(1), RIPK1(1), RPS6KA5(2), SHC1(4), STAT1(6), TGFB2(3), TGFB3(1), TGFBR1(1), TRADD(2), TRAF2(1) 36779176 78 68 76 18 8 6 5 38 20 1 0.446 1.000 1.000 401 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3) 24936921 39 35 34 10 2 4 4 18 11 0 0.702 1.000 1.000 402 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(1), ACADS(3), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), HMGCL(1), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), SDHB(1) 25781560 49 48 45 14 6 8 10 15 10 0 0.430 1.000 1.000 403 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(3), BDKRB2(1), CALM2(1), CHRM1(2), CHRNA1(4), FLT1(10), FLT4(14), KDR(6), NOS3(4), PDE2A(3), PDE3A(4), PDE3B(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKG1(4), PRKG2(3), RYR2(17), SLC7A1(3), SYT1(1), TNNI1(1) 41123979 99 90 99 24 17 15 9 42 16 0 0.140 1.000 1.000 404 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CD28(1), CSK(4), CTLA4(3), DAG1(3), DTYMK(1), EPHB2(2), FBXW7(6), GRAP2(1), GRB2(2), ITK(2), ITPKA(2), ITPKB(2), LAT(1), LCK(1), LCP2(3), NCK1(1), NFAT5(10), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PLCG1(4), PTPRC(8), RAF1(4), RASGRP1(3), RASGRP2(4), RASGRP3(2), RASGRP4(3), SOS1(9), SOS2(7), VAV1(4), ZAP70(1) 55484143 127 103 124 25 13 18 21 43 32 0 0.0515 1.000 1.000 405 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), G6PD(2), GPI(3), H6PD(3), PFKM(3), PFKP(3), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(2), TAL1(3), TALDO1(2), TKT(2) 19900363 42 40 40 13 5 5 6 13 13 0 0.726 1.000 1.000 406 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM2(1), CDKN1A(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1) 20011083 43 38 40 13 5 5 3 10 19 1 0.831 1.000 1.000 407 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(3), CAMK1G(3), ELK1(1), FPR1(2), GNA15(1), GNB1(3), HRAS(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAPK14(1), MAPK3(3), NCF1(1), NCF2(1), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKBIA(2), PAK1(3), PIK3C2G(5), PLCB1(4), PPP3CA(3), PPP3CC(3), RAC1(1), RAF1(4), RELA(6), SYT1(1) 38247438 91 78 85 22 12 10 6 32 30 1 0.500 1.000 1.000 408 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(4), FYN(2), GNA11(1), GNAI1(2), GNB1(3), GRB2(2), HRAS(1), JAK2(7), MAP2K2(1), MAPK14(1), MAPK3(3), MAPT(4), MYLK(4), PLCG1(4), PRKCA(2), PTK2B(3), RAF1(4), SHC1(4), SOS1(9), STAT1(6), STAT3(3), STAT5A(3), SYT1(1) 41878239 86 76 84 19 6 11 11 36 22 0 0.312 1.000 1.000 409 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(8), ACADL(3), ACADM(1), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ECHS1(3), EHHADH(6), HADHA(4), LDHB(2), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(3), SUCLA2(2), SUCLG1(5), SUCLG2(2) 33253878 70 66 66 18 4 9 17 23 15 2 0.326 1.000 1.000 410 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(5), ACY1(4), ADC(2), AGMAT(3), ALDH18A1(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), AMD1(2), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(4), ASS1(3), CPS1(6), GATM(2), MAOA(2), MAOB(2), NAGS(1), ODC1(2), OTC(1), SAT1(1), SAT2(2), SMS(2) 29254429 70 64 68 19 4 8 13 27 18 0 0.542 1.000 1.000 411 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ADC(2), ALDH4A1(2), CAD(13), CPS1(6), EPRS(5), GAD1(2), GAD2(2), GCLC(4), GFPT1(3), GFPT2(1), GLS(7), GLS2(4), GLUD2(7), GLUL(2), GMPS(1), GNPNAT1(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), GSR(1), GSS(1), NADSYN1(1), NAGK(3), PPAT(3), QARS(1) 39509883 84 70 78 20 7 9 17 30 20 1 0.349 1.000 1.000 412 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(6), ACO1(5), CLYBL(3), CS(2), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(3), IDH3G(2), MDH1(2), MDH2(1), OGDH(8), OGDHL(2), PC(8), PCK1(5), PCK2(2), SDHA(9), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(5), SUCLG2(2) 29805307 84 71 81 24 5 15 8 33 22 1 0.562 1.000 1.000 413 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(2), AKT1(3), AKT2(5), AKT3(3), DAG1(3), IKBKG(1), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PIK3CB(5), PITX2(2), PLD1(3), PLD2(7), PLD3(3) 44709441 83 69 81 18 11 12 14 31 15 0 0.0695 1.000 1.000 414 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(7), ADRBK2(2), ARRB2(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA1(2), CLCA4(2), CNGA3(5), CNGA4(4), CNGB1(6), GUCA1B(2), PDC(1), PDE1C(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKG1(4), PRKG2(3), PRKX(2) 30876627 60 57 57 16 8 7 5 28 12 0 0.511 1.000 1.000 415 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(3), AKT2(5), AKT3(3), BRD4(5), CAP1(3), CBL(3), CDC42(1), CDKN2A(5), F2RL2(2), FLOT1(1), FLOT2(1), GRB2(2), GSK3A(3), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(5), IRS4(1), LNPEP(4), MAPK3(3), PARD3(6), PDK1(1), PIK3CA(14), PIK3CD(2), PIK3R1(5), PTEN(34), PTPN1(2), RAF1(4), RPS6KA1(8), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SORBS1(3), SOS1(9), SOS2(7), YWHAE(1) 57220489 167 138 153 31 13 24 27 48 51 4 0.0269 1.000 1.000 416 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(10), APOA1(1), CETP(1), DGAT1(2), LCAT(5), LDLR(3), LIPC(1), LPL(3), LRP1(15), SCARB1(4), SOAT1(4) 26955573 49 45 47 13 4 10 5 19 11 0 0.355 1.000 1.000 417 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(3), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1C4(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), BAAT(2), CEL(3), CYP27A1(1), HADHB(4), SOAT2(4), SRD5A1(1) 23224668 47 44 44 15 4 3 6 22 12 0 0.855 1.000 1.000 418 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(4), AGTR1(2), AGTR2(1), CMA1(1), COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(9), COL4A6(7), REN(1) 25559695 43 40 43 14 4 12 5 16 6 0 0.433 1.000 1.000 419 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(7), ACTG1(3), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), AKT1(3), AKT2(5), AKT3(3), ARHGAP5(6), BAD(1), BCAR1(6), BIRC2(3), BIRC3(5), BRAF(4), CAPN2(4), CAV2(2), CAV3(1), CCND2(1), CDC42(1), CHAD(3), COL11A1(11), COL11A2(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(9), COL5A2(6), COL5A3(12), COL6A1(4), COL6A2(7), COL6A3(21), COL6A6(17), CRKL(1), CTNNB1(2), DIAPH1(7), DOCK1(3), EGF(5), EGFR(10), ELK1(1), ERBB2(8), FARP2(3), FIGF(2), FLNA(6), FLNB(7), FLNC(10), FLT1(10), FN1(8), FYN(2), GRB2(2), GRLF1(6), GSK3B(3), HGF(1), HRAS(1), IBSP(1), IGF1R(3), ILK(4), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAV(1), ITGB1(7), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), JUN(2), KDR(6), LAMA1(12), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(8), MAPK10(2), MAPK3(3), MAPK9(2), MET(22), MYL2(1), MYL7(2), MYL9(1), MYLK(4), MYLK2(1), MYLPF(3), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PARVA(1), PARVB(1), PARVG(2), PDGFC(1), PDGFD(4), PDGFRA(8), PDGFRB(3), PGF(2), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP5K1C(5), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PRKCA(2), PRKCG(6), PTEN(34), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), RAP1A(1), RAPGEF1(6), RELN(7), ROCK1(5), ROCK2(4), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SOS1(9), SOS2(7), SPP1(3), SRC(4), THBS1(15), THBS2(3), THBS3(7), THBS4(4), TLN1(14), TLN2(12), TNC(13), TNN(3), TNR(9), TNXB(11), VAV1(4), VAV2(4), VAV3(1), VCL(2), VEGFC(2), VTN(1), VWF(15), ZYX(1) 367880941 862 433 831 232 86 117 119 312 220 8 0.139 1.000 1.000 420 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 248 ACVR1B(4), ACVR1C(3), AKT1(3), AKT2(5), AKT3(3), ARRB1(3), ARRB2(1), ATF2(2), ATF4(2), BDNF(2), BRAF(4), CACNA1A(14), CACNA1B(5), CACNA1C(18), CACNA1D(9), CACNA1E(3), CACNA1F(4), CACNA1G(11), CACNA1H(8), CACNA1I(7), CACNA1S(14), CACNA2D1(6), CACNA2D2(1), CACNA2D4(5), CACNB1(4), CACNB2(1), CACNB4(1), CACNG2(2), CACNG3(2), CACNG4(1), CACNG5(2), CACNG6(1), CACNG7(1), CACNG8(1), CDC25B(1), CDC42(1), CHUK(2), CRKL(1), DAXX(6), DUSP10(1), DUSP16(1), DUSP3(2), DUSP4(1), DUSP5(2), DUSP6(2), DUSP8(1), DUSP9(2), ECSIT(5), EGF(5), EGFR(10), ELK1(1), ELK4(3), FAS(2), FASLG(3), FGF1(2), FGF10(2), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF3(4), FGF6(4), FGF7(2), FGFR1(6), FGFR2(4), FGFR3(10), FGFR4(3), FLNA(6), FLNB(7), FLNC(10), FOS(1), GADD45B(1), GNA12(1), GNG12(2), GRB2(2), HRAS(1), IKBKB(3), IKBKG(1), IL1B(1), IL1R1(3), IL1R2(8), JUN(2), KRAS(3), MAP2K2(1), MAP2K3(4), MAP2K5(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K10(4), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K6(3), MAP3K7(3), MAP3K8(1), MAP4K1(5), MAP4K2(1), MAP4K3(6), MAP4K4(2), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(4), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MAPKAPK2(1), MAPKAPK5(1), MAPT(4), MAX(5), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), MYC(2), NF1(11), NFATC2(8), NFATC4(3), NFKB1(2), NFKB2(3), NLK(1), NR4A1(1), NRAS(2), NTRK1(8), NTRK2(2), PAK1(3), PAK2(4), PDGFRA(8), PDGFRB(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PPM1A(3), PPM1B(3), PPP3CA(3), PPP3CC(3), PPP3R2(2), PPP5C(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), PTPN5(4), PTPN7(1), PTPRR(5), RAC1(1), RAC2(1), RAC3(1), RAF1(4), RAP1A(1), RAPGEF2(8), RASA1(7), RASA2(2), RASGRF1(8), RASGRF2(4), RASGRP1(3), RASGRP2(4), RASGRP3(2), RASGRP4(3), RPS6KA1(8), RPS6KA3(3), RPS6KA4(2), RPS6KA5(2), RPS6KA6(1), RRAS2(8), SOS1(9), SOS2(7), SRF(1), STK3(1), TAOK2(4), TAOK3(2), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TNF(1), TNFRSF1A(1), TP53(50), TRAF2(1), TRAF6(2), ZAK(4) 287633554 690 386 653 179 85 86 89 251 172 7 0.0699 1.000 1.000 421 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY7(1), ADCY8(13), ADCY9(7), ADORA2A(5), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(8), ATP2A2(7), ATP2A3(5), ATP2B1(4), ATP2B3(2), ATP2B4(4), AVPR1A(1), BDKRB1(1), BDKRB2(1), BST1(2), CACNA1A(14), CACNA1B(5), CACNA1C(18), CACNA1D(9), CACNA1E(3), CACNA1F(4), CACNA1G(11), CACNA1H(8), CACNA1I(7), CACNA1S(14), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CCKAR(4), CCKBR(4), CD38(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CHRNA7(2), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(10), ERBB2(8), ERBB3(8), ERBB4(11), F2R(2), GNA11(1), GNA15(1), GNAS(5), GRIN1(2), GRIN2A(8), GRIN2D(2), GRM1(5), GRM5(9), GRPR(2), HRH2(1), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), LTB4R2(1), MYLK(4), MYLK2(1), NOS1(10), NOS3(4), NTSR1(3), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX5(1), P2RX7(2), PDE1A(1), PDE1B(5), PDE1C(2), PDGFRA(8), PDGFRB(3), PHKA1(10), PHKA2(5), PHKB(6), PHKG1(4), PHKG2(1), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PPID(1), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), PTAFR(2), PTGER3(5), PTGFR(5), PTK2B(3), RYR1(23), RYR2(17), RYR3(17), SLC25A4(2), SLC25A5(4), SLC25A6(2), SLC8A1(3), SLC8A2(3), SLC8A3(5), SPHK1(2), SPHK2(1), TACR1(2), TACR2(2), TACR3(2), TBXA2R(4), TRHR(2), TRPC1(3), VDAC2(1), VDAC3(2) 270534741 599 371 578 177 106 79 64 226 124 0 0.224 1.000 1.000 422 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), APC(9), APC2(5), ARAF(1), ARHGEF1(2), ARHGEF12(5), ARHGEF4(2), ARHGEF6(4), ARHGEF7(5), ARPC1B(2), ARPC2(9), ARPC5L(1), BAIAP2(2), BCAR1(6), BDKRB1(1), BDKRB2(1), BRAF(4), C3orf10(2), CDC42(1), CFL1(1), CFL2(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CRKL(1), CSK(4), CYFIP1(7), CYFIP2(7), DIAPH1(7), DIAPH2(2), DIAPH3(7), DOCK1(3), EGF(5), EGFR(10), EZR(2), F2(4), F2R(2), FGD1(3), FGD3(1), FGF1(2), FGF10(2), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF3(4), FGF6(4), FGF7(2), FGFR1(6), FGFR2(4), FGFR3(10), FGFR4(3), FN1(8), GIT1(4), GNA12(1), GNA13(4), GNG12(2), GRLF1(6), GSN(5), HRAS(1), INS(1), IQGAP1(7), IQGAP2(7), IQGAP3(7), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(7), ITGAM(9), ITGAV(1), ITGAX(8), ITGB1(7), ITGB2(2), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), KRAS(3), LIMK1(7), LIMK2(4), MAP2K2(1), MAPK3(3), MOS(1), MRAS(1), MSN(3), MYH10(3), MYH14(8), MYH9(5), MYL2(1), MYL7(2), MYL9(1), MYLK(4), MYLK2(1), MYLPF(3), NCKAP1(3), NCKAP1L(5), NRAS(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDGFRA(8), PDGFRB(3), PFN2(1), PFN3(1), PFN4(1), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(5), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PPP1R12B(2), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), RDX(2), ROCK1(5), ROCK2(4), RRAS2(8), SCIN(4), SLC9A1(3), SOS1(9), SOS2(7), SSH1(2), SSH2(12), SSH3(2), TIAM1(9), TIAM2(1), VAV1(4), VAV2(4), VAV3(1), VCL(2), WAS(1), WASF1(1), WASF2(2), WASL(7) 278077848 640 368 599 155 63 85 86 240 162 4 0.0388 1.000 1.000 423 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(7), ACTG1(3), CHAD(3), COL11A1(11), COL11A2(5), COL17A1(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(9), COL5A2(6), COL5A3(12), COL6A1(4), COL6A2(7), COL6A3(21), COL6A6(17), DES(1), DSC2(5), DSC3(3), DSG1(4), DSG2(3), DSG3(3), DSG4(5), FN1(8), GJA10(3), GJA3(2), GJA4(1), GJA5(5), GJA8(2), GJA9(1), GJB1(2), GJB3(2), GJB5(1), GJB6(2), GJC1(3), GJC2(1), GJD2(1), IBSP(1), ITGA6(6), ITGB4(6), KRT1(3), KRT10(2), KRT12(2), KRT13(6), KRT15(3), KRT16(1), KRT17(3), KRT18(1), KRT19(2), KRT2(6), KRT20(1), KRT23(3), KRT24(1), KRT25(1), KRT27(4), KRT28(2), KRT3(2), KRT31(1), KRT32(1), KRT33A(1), KRT33B(2), KRT34(1), KRT35(3), KRT36(2), KRT37(1), KRT38(2), KRT39(1), KRT4(5), KRT40(2), KRT5(3), KRT6A(3), KRT6B(3), KRT6C(1), KRT7(1), KRT71(3), KRT72(2), KRT73(2), KRT74(2), KRT75(4), KRT76(4), KRT77(4), KRT78(3), KRT79(4), KRT81(1), KRT82(2), KRT83(2), KRT84(4), KRT85(6), KRT86(2), KRT9(2), LAMA1(12), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(8), LMNB1(3), LMNB2(1), NES(8), PRPH(3), RELN(7), SPP1(3), THBS1(15), THBS2(3), THBS3(7), THBS4(4), TNC(13), TNN(3), TNR(9), TNXB(11), VIM(2), VTN(1), VWF(15) 243650837 554 332 540 191 64 75 65 202 146 2 0.940 1.000 1.000 424 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(2), ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA2B(1), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), C5AR1(3), CALCR(3), CALCRL(2), CCKAR(4), CCKBR(4), CGA(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CNR1(1), CNR2(3), CRHR1(2), CRHR2(3), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(3), DRD5(4), EDNRB(3), F2(4), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GABBR1(5), GABRA1(2), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GABRB1(3), GABRB2(3), GABRB3(2), GABRD(2), GABRE(5), GABRG1(3), GABRG2(6), GABRG3(3), GABRQ(8), GABRR1(2), GABRR2(1), GALR1(1), GH2(1), GHR(1), GIPR(2), GLP1R(3), GLP2R(3), GLRA1(3), GLRA2(2), GLRB(2), GPR156(1), GPR35(3), GPR50(3), GPR63(1), GPR83(2), GRIA1(8), GRIA2(4), GRIA3(2), GRIA4(4), GRID1(4), GRID2(9), GRIK1(4), GRIK2(5), GRIK3(6), GRIK5(5), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), GRIN3A(2), GRIN3B(5), GRM1(5), GRM2(5), GRM3(5), GRM4(6), GRM5(9), GRM6(2), GRM7(5), GRM8(4), GRPR(2), HCRTR1(2), HCRTR2(5), HRH2(1), HRH3(2), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), LEP(1), LEPR(5), LTB4R2(1), MAS1(1), MC2R(3), MC3R(2), MC4R(1), MC5R(1), MCHR1(1), MCHR2(2), MLNR(1), MTNR1B(1), NMBR(1), NMUR2(6), NPBWR1(2), NPBWR2(1), NPFFR2(3), NPY1R(2), NPY2R(2), NR3C1(4), NTSR1(3), OPRD1(3), OPRK1(2), OPRM1(3), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX5(1), P2RX7(2), P2RY1(3), P2RY10(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY4(1), P2RY6(2), P2RY8(2), PARD3(6), PRLR(3), PRSS1(6), PRSS3(12), PTAFR(2), PTGDR(2), PTGER2(1), PTGER3(5), PTGER4(1), PTGFR(5), PTGIR(2), RXFP1(1), RXFP2(3), SCTR(1), SSTR1(4), SSTR2(2), SSTR3(2), SSTR4(3), TAAR2(2), TAAR9(2), TACR1(2), TACR2(2), TACR3(2), TBXA2R(4), THRA(2), TRHR(2), TRPV1(1), TSHR(2), TSPO(1), UTS2R(2), VIPR1(1), VIPR2(2) 215683005 495 311 479 160 79 69 70 184 93 0 0.451 1.000 1.000 425 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(10), CD36(1), CD44(3), CHAD(3), COL11A1(11), COL11A2(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(9), COL5A2(6), COL5A3(12), COL6A1(4), COL6A2(7), COL6A3(21), COL6A6(17), DAG1(3), FN1(8), FNDC1(3), FNDC3A(4), FNDC5(1), GP6(1), GP9(1), HMMR(1), HSPG2(14), IBSP(1), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAV(1), ITGB1(7), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), LAMA1(12), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(8), RELN(7), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SPP1(3), SV2A(1), SV2B(3), SV2C(3), THBS1(15), THBS2(3), THBS3(7), THBS4(4), TNC(13), TNN(3), TNR(9), TNXB(11), VTN(1), VWF(15) 220714199 475 309 462 144 50 62 61 168 131 3 0.636 1.000 1.000 426 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(7), ACTG1(3), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), AKT1(3), AKT2(5), AKT3(3), AMOTL1(4), ASH1L(8), CASK(2), CDC42(1), CDK4(6), CGN(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CSDA(4), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(7), CTNNA2(8), CTNNA3(3), CTNNB1(2), EPB41(2), EPB41L1(4), EPB41L2(2), EPB41L3(7), EXOC4(3), F11R(1), GNAI1(2), GNAI2(2), GNAI3(2), HCLS1(1), HRAS(1), IGSF5(5), INADL(10), JAM3(1), KRAS(3), LLGL1(5), LLGL2(3), MAGI1(5), MAGI2(6), MAGI3(4), MLLT4(11), MPDZ(4), MPP5(1), MRAS(1), MYH1(5), MYH10(3), MYH11(10), MYH13(7), MYH14(8), MYH15(5), MYH2(9), MYH3(7), MYH4(15), MYH6(7), MYH7(13), MYH7B(7), MYH8(6), MYH9(5), MYL2(1), MYL7(2), MYL9(1), MYLPF(3), NRAS(2), OCLN(3), PARD3(6), PARD6B(8), PPM1J(3), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(2), PTEN(34), RAB13(1), RAB3B(1), RRAS2(8), SPTAN1(12), SRC(4), SYMPK(1), TJAP1(4), TJP1(6), TJP2(4), TJP3(1), YES1(2), ZAK(4) 193783294 461 290 435 132 44 54 58 144 156 5 0.724 1.000 1.000 427 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ADRA1A(4), ADRB2(2), ANXA6(3), ARRB1(3), ARRB2(1), ATP1A4(4), ATP1B1(5), ATP2A2(7), ATP2A3(5), ATP2B1(4), ATP2B3(2), CACNA1A(14), CACNA1B(5), CACNA1C(18), CACNA1D(9), CACNA1E(3), CACNA1S(14), CACNB1(4), CALM2(1), CALR(2), CAMK1(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CASQ1(4), CASQ2(2), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), GJA4(1), GJA5(5), GJB1(2), GJB3(2), GJB5(1), GJB6(2), GNA11(1), GNAI2(2), GNAI3(2), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(2), GNG12(2), GNG3(1), GNG7(1), GRK4(2), GRK5(2), GRK6(5), ITPR1(7), ITPR2(13), ITPR3(5), KCNB1(2), KCNJ3(4), MIB1(1), MYCBP(1), NME7(2), PKIA(1), PKIB(1), PLCB3(3), PRKACA(2), PRKACB(5), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), PRKCZ(2), PRKD1(4), RGS1(1), RGS11(1), RGS14(1), RGS16(2), RGS17(2), RGS18(2), RGS19(1), RGS2(2), RGS20(1), RGS3(8), RGS6(3), RGS7(2), RGS9(5), RYR1(23), RYR2(17), RYR3(17), SFN(1), SLC8A1(3), SLC8A3(5), USP5(4) 189765843 419 284 408 128 75 53 42 150 99 0 0.392 1.000 1.000 428 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(1), ACVR1B(4), ACVR2A(4), ACVR2B(1), AMHR2(9), BMP2(2), BMP7(5), BMPR1A(1), BMPR1B(2), BMPR2(5), CCL2(1), CCL27(2), CCL3(1), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CCR9(1), CD27(3), CD40(1), CLCF1(1), CNTF(1), CSF1R(8), CSF2RA(5), CSF2RB(5), CSF3R(4), CX3CL1(2), CX3CR1(1), CXCL1(1), CXCL11(1), CXCL13(1), CXCL16(1), CXCL5(1), CXCL9(1), CXCR4(1), CXCR6(1), EDA(2), EDA2R(1), EGF(5), EGFR(10), EPOR(3), FAS(2), FASLG(3), FLT1(10), FLT3(6), FLT4(14), GDF5(5), GH2(1), GHR(1), HGF(1), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IFNGR1(3), IFNGR2(2), IFNK(1), IL10RA(4), IL11RA(2), IL12RB1(4), IL12RB2(2), IL13RA1(2), IL15(1), IL15RA(3), IL17RA(1), IL17RB(4), IL18R1(1), IL18RAP(4), IL19(2), IL1B(1), IL1R1(3), IL1R2(8), IL1RAP(4), IL20RA(1), IL21(1), IL21R(5), IL22(1), IL22RA1(3), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL6ST(6), IL7R(1), IL9(1), IL9R(6), INHBA(2), INHBB(2), INHBC(1), INHBE(1), KDR(6), KIT(3), KITLG(2), LEP(1), LEPR(5), LIFR(5), LTA(1), LTB(1), LTBR(2), MET(22), NGFR(1), OSM(2), OSMR(1), PDGFC(1), PDGFRA(8), PDGFRB(3), PF4(1), PLEKHO2(1), PRLR(3), RELT(1), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF19(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(9), TNFSF13(1), TNFSF14(1), TNFSF15(2), TNFSF8(2), TNFSF9(1), TPO(4), VEGFC(2), XCL1(3), XCR1(1) 175827295 400 284 382 76 37 56 52 167 88 0 0.000418 1.000 1.000 429 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(9), ABLIM1(5), ABLIM2(2), ABLIM3(3), ARHGEF12(5), CDC42(1), CFL1(1), CFL2(1), CXCR4(1), DCC(7), DPYSL2(4), EFNA1(2), EFNA3(1), EFNB1(1), EFNB2(1), EFNB3(12), EPHA1(4), EPHA2(1), EPHA3(5), EPHA4(2), EPHA5(5), EPHA6(4), EPHA7(2), EPHA8(7), EPHB1(4), EPHB2(2), EPHB4(6), EPHB6(7), FES(4), FYN(2), GNAI1(2), GNAI2(2), GNAI3(2), GSK3B(3), HRAS(1), ITGB1(7), KRAS(3), L1CAM(5), LIMK1(7), LIMK2(4), LRRC4C(2), MAPK3(3), MET(22), NCK1(1), NCK2(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NGEF(1), NRAS(2), NRP1(2), NTN4(2), NTNG1(3), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PLXNA1(4), PLXNA2(10), PLXNA3(5), PLXNB1(10), PLXNB2(6), PLXNB3(4), PLXNC1(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PTK2(3), RAC1(1), RAC2(1), RAC3(1), RASA1(7), RGS3(8), RND1(3), ROBO1(5), ROBO2(9), ROBO3(4), ROCK1(5), ROCK2(4), SEMA3A(4), SEMA3B(1), SEMA3C(2), SEMA3D(4), SEMA3E(3), SEMA3F(2), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(2), SEMA4F(7), SEMA4G(4), SEMA5A(6), SEMA5B(2), SEMA6A(3), SEMA6B(2), SEMA6C(4), SEMA6D(3), SEMA7A(1), SLIT1(3), SLIT2(9), SLIT3(8), SRGAP1(10), SRGAP2(3), SRGAP3(4), UNC5A(4), UNC5B(5), UNC5C(3), UNC5D(2) 193437899 445 279 406 119 47 55 52 163 126 2 0.420 1.000 1.000 430 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(9), APC2(5), AXIN1(5), AXIN2(1), BTRC(2), CACYBP(4), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CER1(1), CHD8(6), CREBBP(10), CSNK1A1(2), CSNK1E(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTBP1(2), CTBP2(3), CTNNB1(2), CUL1(5), CXXC4(2), DAAM1(5), DAAM2(1), DKK2(1), DVL1(1), DVL2(1), EP300(16), FBXW11(2), FZD1(4), FZD10(4), FZD2(2), FZD3(1), FZD4(4), FZD5(2), FZD7(1), GSK3B(3), JUN(2), LEF1(3), LRP5(6), LRP6(8), MAP3K7(3), MAPK10(2), MAPK9(2), MYC(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NKD1(4), NKD2(4), NLK(1), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PORCN(2), PPARD(1), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRICKLE1(4), PRICKLE2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), RAC1(1), RAC2(1), RAC3(1), RBX1(1), ROCK1(5), ROCK2(4), SENP2(1), SFRP2(1), SFRP4(2), SFRP5(2), SMAD2(2), SMAD3(2), SMAD4(3), TBL1X(3), TBL1XR1(5), TCF7L1(2), TCF7L2(1), TP53(50), VANGL1(5), VANGL2(3), WIF1(5), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1) 158087262 392 271 370 88 40 41 53 138 116 4 0.0187 1.000 1.000 431 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 130 ACACA(8), ACACB(5), AKT1(3), AKT2(5), AKT3(3), ARAF(1), BAD(1), BRAF(4), CALM2(1), CBL(3), CBLB(4), CBLC(2), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(6), FASN(9), FBP1(1), FLOT1(1), FLOT2(1), FOXO1(5), G6PC(3), GCK(2), GRB2(2), GSK3B(3), GYS1(3), GYS2(3), HRAS(1), IKBKB(3), INPP5D(2), INS(1), INSR(6), IRS1(5), IRS4(1), KRAS(3), LIPE(6), MAP2K2(1), MAPK10(2), MAPK3(3), MAPK9(2), MKNK1(2), MKNK2(1), NRAS(2), PCK1(5), PCK2(2), PDE3A(4), PDE3B(3), PFKL(3), PFKM(3), PFKP(3), PHKA1(10), PHKA2(5), PHKB(6), PHKG1(4), PHKG2(1), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PKLR(1), PKM2(1), PPARGC1A(4), PPP1CA(1), PPP1CC(2), PPP1R3A(4), PPP1R3B(1), PPP1R3C(1), PPP1R3D(1), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKACA(2), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAG2(6), PRKAG3(1), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCI(5), PRKCZ(2), PRKX(2), PTPN1(2), PTPRF(8), PYGB(3), PYGL(2), PYGM(4), RAF1(4), RAPGEF1(6), RHEB(5), RHOQ(1), RPS6KB1(2), RPS6KB2(2), SH2B2(2), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SLC2A4(3), SOCS3(1), SOCS4(1), SORBS1(3), SOS1(9), SOS2(7), SREBF1(4), TRIP10(2), TSC1(6), TSC2(13) 157816448 369 266 349 77 35 60 52 143 76 3 0.00136 1.000 1.000 432 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ACTA2(1), ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ARRB1(3), ARRB2(1), ATF1(2), ATF2(2), ATF3(1), ATF4(2), ATF5(1), ATP2A2(7), ATP2A3(5), CALCA(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(3), CORIN(2), CREB3(2), CRHR1(2), DGKZ(5), ETS2(1), FOS(1), GABPA(2), GABPB2(1), GBA2(5), GNB1(3), GNB3(2), GNB5(2), GNG12(2), GNG3(1), GNG7(1), GRK4(2), GRK5(2), GRK6(5), GSTO1(1), GUCA2A(1), GUCA2B(1), GUCY1A3(3), IGFBP1(1), IGFBP2(3), IGFBP3(1), IGFBP4(2), IGFBP6(3), IL1B(1), ITPR1(7), ITPR2(13), ITPR3(5), JUN(2), MIB1(1), MYL2(1), MYLK2(1), NFKB1(2), NOS1(10), NOS3(4), OXTR(1), PDE4B(2), PDE4D(2), PKIA(1), PKIB(1), PLCB3(3), PLCD1(3), PLCG1(4), PLCG2(4), PRKACA(2), PRKACB(5), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCH(4), PRKCQ(5), PRKCZ(2), PRKD1(4), RAMP1(1), RAMP2(1), RAMP3(1), RGS1(1), RGS11(1), RGS14(1), RGS16(2), RGS17(2), RGS18(2), RGS19(1), RGS2(2), RGS20(1), RGS3(8), RGS6(3), RGS7(2), RGS9(5), RLN1(1), RYR1(23), RYR2(17), RYR3(17), SFN(1), SLC8A1(3), SP1(2), TNXB(11), USP5(4) 172236472 363 261 356 99 56 52 38 132 85 0 0.240 1.000 1.000 433 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(4), CADM1(3), CADM3(3), CD2(2), CD22(4), CD276(2), CD28(1), CD34(2), CD4(10), CD40(1), CD58(1), CD6(3), CD80(1), CD86(3), CD8A(1), CD99(2), CDH1(2), CDH15(1), CDH2(7), CDH3(3), CDH4(6), CDH5(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CNTN1(7), CNTN2(3), CNTNAP1(9), CNTNAP2(5), CTLA4(3), ESAM(3), F11R(1), GLG1(5), HLA-A(6), HLA-B(10), HLA-C(10), HLA-DOA(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(10), HLA-E(2), HLA-F(2), ICAM1(3), ICOS(3), ICOSLG(1), ITGA4(3), ITGA6(6), ITGA8(3), ITGA9(3), ITGAL(7), ITGAM(9), ITGAV(1), ITGB1(7), ITGB2(2), ITGB7(4), ITGB8(1), JAM3(1), L1CAM(5), MADCAM1(3), MAG(1), MPZL1(2), NCAM1(3), NCAM2(6), NEGR1(2), NEO1(5), NFASC(8), NRCAM(5), NRXN1(10), NRXN2(6), NRXN3(5), OCLN(3), PDCD1(1), PTPRC(8), PTPRF(8), PTPRM(8), PVRL1(1), PVRL2(6), PVRL3(4), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SELE(6), SELL(2), SELP(2), SELPLG(3), SIGLEC1(5), SPN(1), VCAM1(6), VCAN(16) 143992420 378 258 366 131 36 47 55 156 83 1 0.935 1.000 1.000 434 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(8), ASH2L(3), CTCFL(5), DOT1L(9), EED(1), EHMT1(4), EHMT2(9), EZH1(3), EZH2(4), FBXO11(6), HCFC1(8), HSF4(3), JMJD4(1), JMJD6(5), KDM6A(11), MEN1(1), MLL(6), MLL2(26), MLL3(38), MLL4(8), MLL5(9), NSD1(13), OGT(5), PAXIP1(4), PPP1CA(1), PPP1CC(2), PRDM2(4), PRDM6(1), PRDM7(5), PRDM9(8), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), RBBP5(5), SATB1(4), SETD1A(8), SETD1B(2), SETD2(72), SETD7(1), SETDB1(8), SETMAR(2), SMYD3(2), SUV39H2(5), SUV420H1(3), SUZ12(6), WHSC1(6), WHSC1L1(6) 121267645 351 253 346 70 27 40 42 112 125 5 0.0114 1.000 1.000 435 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), AKT2(5), AKT3(3), CBL(3), CBLB(4), CBLC(2), CCND2(1), CISH(2), CLCF1(1), CNTF(1), CREBBP(10), CSF2RA(5), CSF2RB(5), CSF3R(4), EP300(16), EPOR(3), GH2(1), GHR(1), GRB2(2), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IFNGR1(3), IFNGR2(2), IFNK(1), IL10RA(4), IL11RA(2), IL12RB1(4), IL12RB2(2), IL13RA1(2), IL15(1), IL15RA(3), IL19(2), IL20RA(1), IL21(1), IL21R(5), IL22(1), IL22RA1(3), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL6ST(6), IL7R(1), IL9(1), IL9R(6), IRF9(2), JAK1(7), JAK2(7), JAK3(4), LEP(1), LEPR(5), LIFR(5), MYC(2), OSM(2), OSMR(1), PIAS1(5), PIAS2(3), PIAS3(3), PIAS4(1), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PRLR(3), PTPN11(2), PTPN6(3), SOCS3(1), SOCS4(1), SOCS5(2), SOCS7(2), SOS1(9), SOS2(7), SPRED1(6), SPRED2(2), SPRY1(1), SPRY2(3), SPRY4(10), STAM(6), STAT1(6), STAT2(6), STAT3(3), STAT4(2), STAT5A(3), STAT5B(3), STAT6(5), TPO(4), TYK2(7) 144480171 350 240 329 79 27 53 58 130 82 0 0.0349 1.000 1.000 436 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(2), ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ADK(1), ADSL(3), ADSSL1(2), AK2(3), AK5(2), AK7(3), ALLC(3), AMPD1(2), AMPD2(5), AMPD3(4), ATIC(2), CANT1(1), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(1), ENTPD2(1), ENTPD5(3), ENTPD6(2), GART(4), GDA(3), GMPR(2), GMPS(1), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HPRT1(1), IMPDH1(1), IMPDH2(2), NME7(2), NPR1(4), NPR2(5), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5M(2), NUDT5(4), NUDT9(1), PAPSS1(3), PAPSS2(4), PDE10A(1), PDE11A(7), PDE1A(1), PDE1C(2), PDE2A(3), PDE3B(3), PDE4A(3), PDE4B(2), PDE4C(7), PDE4D(2), PDE5A(5), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(2), PDE9A(10), PFAS(3), PKLR(1), PKM2(1), PNPT1(2), POLA1(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PPAT(3), PRIM1(3), PRIM2(7), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RFC5(3), RRM1(3), RRM2(1), XDH(7) 163976468 330 231 315 76 32 46 37 128 87 0 0.0957 1.000 1.000 437 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(9), ANAPC1(4), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC4(6), ANAPC5(3), ANAPC7(2), ATM(20), ATR(12), BUB1(2), BUB1B(1), BUB3(1), CCNA1(8), CCNB1(1), CCNB2(6), CCNB3(6), CCND2(1), CCNE1(3), CCNE2(4), CCNH(1), CDC14A(5), CDC14B(1), CDC16(4), CDC20(3), CDC23(2), CDC25A(1), CDC25B(1), CDC25C(3), CDC27(14), CDC6(2), CDC7(2), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(5), CDKN2C(1), CHEK1(1), CHEK2(2), CREBBP(10), CUL1(5), E2F1(1), E2F2(1), E2F3(1), EP300(16), ESPL1(13), FZR1(4), GADD45B(1), GSK3B(3), HDAC1(2), MAD1L1(1), MAD2L1(1), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), ORC1L(1), ORC2L(1), PCNA(4), PKMYT1(1), PLK1(1), PRKDC(13), PTTG2(1), RB1(4), RBL2(5), RBX1(1), SFN(1), SKP2(1), SMAD2(2), SMAD3(2), SMAD4(3), SMC1A(4), SMC1B(4), TGFB2(3), TGFB3(1), TP53(50), WEE1(2), YWHAE(1) 136939438 345 229 321 75 33 43 49 111 102 7 0.00827 1.000 1.000 438 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(3), BCAR1(6), CAPN1(3), CAPN10(2), CAPN11(5), CAPN2(4), CAPN3(8), CAPN5(3), CAPN6(2), CAPN7(4), CAPN9(3), CAV2(2), CAV3(1), CDC42(1), CSK(4), DOCK1(3), FYN(2), GIT2(4), GRB2(2), ILK(4), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(7), ITGAM(9), ITGAV(1), ITGAX(8), ITGB1(7), ITGB2(2), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAPK10(2), MAPK12(1), MAPK4(2), MAPK6(1), MAPK7(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PIK3R2(3), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAPGEF1(6), RHO(1), ROCK1(5), ROCK2(4), SDCCAG8(1), SEPP1(4), SHC1(4), SHC3(2), SORBS1(3), SOS1(9), SRC(4), TLN1(14), TNS1(9), VAV2(4), VAV3(1), VCL(2), ZYX(1) 134851201 310 228 299 93 26 49 43 122 68 2 0.583 1.000 1.000 439 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), DRD1(1), DRD2(1), EGF(5), EGFR(10), GJD2(1), GNA11(1), GNAI1(2), GNAI2(2), GNAI3(2), GNAS(5), GRB2(2), GRM1(5), GRM5(9), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HRAS(1), HTR2A(1), HTR2B(1), HTR2C(1), ITPR1(7), ITPR2(13), ITPR3(5), KRAS(3), MAP2K2(1), MAP2K5(4), MAP3K2(2), MAPK3(3), MAPK7(4), NPR1(4), NPR2(5), NRAS(2), PDGFC(1), PDGFD(4), PDGFRA(8), PDGFRB(3), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKG1(4), PRKG2(3), PRKX(2), RAF1(4), SOS1(9), SOS2(7), SRC(4), TJP1(6), TUBA1A(3), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB8(4) 131344298 295 213 288 92 36 46 30 120 63 0 0.695 1.000 1.000 440 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(7), ACTG1(3), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), ACVR1B(4), ACVR1C(3), BAIAP2(2), CDC42(1), CDH1(2), CREBBP(10), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(7), CTNNA2(8), CTNNA3(3), CTNNB1(2), CTNND1(5), EGFR(10), EP300(16), ERBB2(8), FARP2(3), FER(2), FGFR1(6), FYN(2), IGF1R(3), INSR(6), IQGAP1(7), LEF1(3), LMO7(12), MAP3K7(3), MAPK3(3), MET(22), MLLT4(11), NLK(1), PARD3(6), PTPN1(2), PTPN6(3), PTPRB(5), PTPRF(8), PTPRJ(12), PTPRM(8), PVRL1(1), PVRL2(6), PVRL3(4), RAC1(1), RAC2(1), RAC3(1), SMAD2(2), SMAD3(2), SMAD4(3), SNAI1(1), SNAI2(3), SORBS1(3), SRC(4), SSX2IP(5), TCF7L1(2), TCF7L2(1), TGFBR1(1), TGFBR2(2), TJP1(6), VCL(2), WAS(1), WASF1(1), WASF2(2), WASF3(3), WASL(7), YES1(2) 119883384 301 212 280 78 32 37 49 108 73 2 0.231 1.000 1.000 441 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(1), BID(2), BRAF(4), CD48(1), FAS(2), FASLG(3), FCER1G(1), FCGR3B(2), FYN(2), GRB2(2), HCST(1), HLA-A(6), HLA-B(10), HLA-C(10), HLA-E(2), HRAS(1), ICAM1(3), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IFNGR1(3), IFNGR2(2), ITGAL(7), ITGB2(2), KIR2DL1(1), KIR2DL3(1), KIR2DL4(1), KIR3DL1(3), KIR3DL2(1), KLRC1(3), KLRC2(5), KLRC3(1), KRAS(3), LAT(1), LCK(1), LCP2(3), MAP2K2(1), MAPK3(3), MICA(1), MICB(4), NCR1(1), NCR2(1), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NRAS(2), PAK1(3), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRF1(1), PRKCA(2), PRKCG(6), PTK2B(3), PTPN11(2), PTPN6(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), SH2D1B(1), SH3BP2(6), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SOS1(9), SOS2(7), SYK(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFSF10(9), ULBP1(2), ULBP2(1), ULBP3(1), VAV1(4), VAV2(4), VAV3(1), ZAP70(1) 111508936 300 212 285 73 24 49 41 116 69 1 0.134 1.000 1.000 442 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ATF4(2), CACNA1C(18), CACNA1D(9), CACNA1F(4), CACNA1S(14), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), CGA(1), EGFR(10), ELK1(1), GNA11(1), GNAS(5), GRB2(2), HRAS(1), ITPR1(7), ITPR2(13), ITPR3(5), JUN(2), KRAS(3), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(4), MAPK9(2), MMP14(1), MMP2(7), NRAS(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLD1(3), PLD2(7), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCD(5), PRKX(2), PTK2B(3), RAF1(4), SOS1(9), SOS2(7), SRC(4) 128842288 290 211 281 89 41 47 31 115 56 0 0.444 1.000 1.000 443 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM2(1), CDS2(2), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), FN3K(1), IMPA1(1), IMPA2(3), INPP4A(2), INPP4B(4), INPP5A(1), INPP5B(5), INPP5D(2), INPP5E(3), INPPL1(4), ITPK1(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), OCRL(3), PI4KA(10), PI4KB(3), PIK3C2A(6), PIK3C2B(6), PIK3C2G(5), PIK3C3(4), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PRKCA(2), PRKCG(6), PTEN(34), PTPMT1(2), SYNJ1(6), SYNJ2(6) 125629140 285 206 272 73 27 47 29 98 80 4 0.180 1.000 1.000 444 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(9), ACTN1(1), ACTR2(2), AKT1(3), AKT2(5), AKT3(3), ARHGEF6(4), ARHGEF7(5), BCAR1(6), BRAF(4), CDC42(1), CDKN2A(5), CSE1L(4), DOCK1(3), EPHB2(2), FYN(2), GRB2(2), GRB7(5), GRLF1(6), ILK(4), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGB3BP(1), MAP2K7(1), MAP3K11(2), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), P4HB(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PIK3CA(14), PIK3CB(5), PKLR(1), PLCG1(4), PLCG2(4), PTEN(34), PTK2(3), RAF1(4), RALA(2), RHO(1), ROCK1(5), ROCK2(4), SHC1(4), SOS1(9), SOS2(7), SRC(4), TLN1(14), TLN2(12), WAS(1), ZYX(1) 122144307 305 206 293 75 19 49 42 109 79 7 0.166 1.000 1.000 445 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADK(1), ADSL(3), AK2(3), AK5(2), ALLC(3), AMPD1(2), AMPD2(5), AMPD3(4), ATIC(2), ATP1B1(5), ATP5A1(3), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G2(1), CANT1(1), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(1), ENTPD2(1), GART(4), GDA(3), GMPS(1), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HPRT1(1), IMPDH1(1), IMPDH2(2), NPR1(4), NPR2(5), NT5M(2), PAPSS1(3), PAPSS2(4), PDE1A(1), PDE4A(3), PDE4B(2), PDE4C(7), PDE4D(2), PDE5A(5), PDE6B(6), PDE6C(3), PDE7B(1), PDE8A(2), PDE9A(10), PFAS(3), PKLR(1), PKM2(1), POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(13), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLRMT(5), PPAT(3), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RRM1(3), RRM2(1) 127786456 279 204 267 56 32 36 32 103 76 0 0.0232 1.000 1.000 446 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), ARHGAP5(6), BCAR1(6), CD99(2), CDC42(1), CDH5(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CTNNA1(7), CTNNA2(8), CTNNA3(3), CTNNB1(2), CTNND1(5), CXCR4(1), ESAM(3), EZR(2), F11R(1), GNAI1(2), GNAI2(2), GNAI3(2), GRLF1(6), ICAM1(3), ITGA4(3), ITGAL(7), ITGAM(9), ITGB1(7), ITGB2(2), ITK(2), JAM3(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(11), MMP2(7), MMP9(1), MSN(3), MYL2(1), MYL7(2), MYL9(1), MYLPF(3), NCF1(1), NCF2(1), NOX1(7), NOX3(6), OCLN(3), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCG(6), PTK2(3), PTK2B(3), PTPN11(2), PXN(3), RAC1(1), RAC2(1), RAP1A(1), RAPGEF3(3), RAPGEF4(2), ROCK1(5), ROCK2(4), SIPA1(4), TXK(1), VAV1(4), VAV2(4), VAV3(1), VCAM1(6), VCL(2) 124181197 275 200 260 75 35 39 32 99 69 1 0.375 1.000 1.000 447 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(1), ACVR1B(4), ACVRL1(1), AKT1(3), AURKB(2), BMPR1A(1), BMPR2(5), BUB1(2), CDKL1(1), CDKL2(4), CDS2(2), CLK1(5), CLK2(2), CLK4(5), COL4A3BP(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), IMPA1(1), INPP4A(2), INPP4B(4), INPP5A(1), INPPL1(4), ITPKA(2), ITPKB(2), MAP3K10(4), MOS(1), NEK1(3), NEK3(3), OCRL(3), PAK4(3), PIK3C2A(6), PIK3C2B(6), PIK3C2G(5), PIK3CA(14), PIK3CB(5), PIK3CG(4), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCG1(4), PLCG2(4), PLK3(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), PRKCZ(2), PRKD1(4), PRKG1(4), RAF1(4), RPS6KA1(8), RPS6KA3(3), RPS6KA4(2), RPS6KB1(2), STK11(3), TGFBR1(1), VRK1(1) 113730773 262 198 249 57 24 43 25 93 76 1 0.0355 1.000 1.000 448 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(4), CACNA1A(14), CRHR1(2), GNA11(1), GNA12(1), GNA13(4), GNAI1(2), GNAI2(2), GNAI3(2), GNAO1(1), GNAS(5), GNAZ(4), GRIA1(8), GRIA2(4), GRIA3(2), GRID2(9), GRM1(5), GRM5(9), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HRAS(1), IGF1R(3), ITPR1(7), ITPR2(13), ITPR3(5), KRAS(3), LYN(1), MAP2K2(1), MAPK3(3), NOS1(10), NOS3(4), NPR1(4), NPR2(5), NRAS(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), PRKCA(2), PRKCG(6), PRKG1(4), PRKG2(3), RAF1(4), RYR1(23) 110431542 254 196 250 71 44 27 30 99 53 1 0.338 1.000 1.000 449 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), CCBP2(2), CCKAR(4), CCKBR(4), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CCR9(1), CCRL1(2), CCRL2(1), CHML(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(3), DRD5(4), EDNRB(3), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(3), GPR174(4), GPR27(1), GPR3(1), GPR35(3), GPR37(3), GPR37L1(2), GPR4(1), GPR50(3), GPR63(1), GPR77(1), GPR83(2), GPR85(3), GPR87(3), GRPR(2), HCRTR1(2), HCRTR2(5), HRH2(1), HRH3(2), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MLNR(1), MTNR1B(1), NMBR(1), NMUR2(6), NPY1R(2), NPY2R(2), NTSR1(3), OPN1SW(2), OPRD1(3), OPRK1(2), OPRM1(3), OR11A1(1), OR12D3(1), OR1C1(1), OR1F1(2), OR1Q1(1), OR5V1(4), OR7A5(2), OR7C1(2), OR8B8(2), OXTR(1), P2RY1(3), P2RY10(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY6(2), PTAFR(2), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), RHO(1), SSTR1(4), SSTR2(2), SSTR3(2), SSTR4(3), SUCNR1(1), TBXA2R(4), TRHR(2) 115924315 251 195 249 86 43 31 33 104 40 0 0.525 1.000 1.000 450 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(1), ACTN2(3), ACTN3(1), ACTN4(3), DES(1), DMD(13), FAM48A(1), MYBPC1(5), MYBPC2(4), MYBPC3(3), MYH3(7), MYH6(7), MYH7(13), MYH8(6), MYL1(4), MYL2(1), MYL9(1), MYOM1(6), NEB(23), TCAP(1), TMOD1(6), TNNI1(1), TNNT1(2), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TPM4(1), TTN(124), VIM(2) 140734031 245 194 239 75 23 42 28 99 49 4 0.588 1.000 1.000 451 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(9), ABL2(6), AKT1(3), AKT2(5), AKT3(3), ARAF(1), AREG(1), BAD(1), BRAF(4), BTC(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(3), CBLB(4), CBLC(2), CDKN1A(3), CDKN1B(1), CRKL(1), EGF(5), EGFR(10), EIF4EBP1(1), ELK1(1), ERBB2(8), ERBB3(8), ERBB4(11), GAB1(2), GRB2(2), GSK3B(3), HRAS(1), JUN(2), KRAS(3), MAP2K2(1), MAP2K7(1), MAPK10(2), MAPK3(3), MAPK9(2), MYC(2), NCK1(1), NCK2(2), NRAS(2), NRG1(6), NRG2(4), NRG3(5), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCG(6), PTK2(3), RAF1(4), RPS6KB1(2), RPS6KB2(2), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SOS1(9), SOS2(7), SRC(4), STAT5A(3), STAT5B(3), TGFA(1) 102262937 263 193 249 52 25 43 45 100 48 2 0.00456 1.000 1.000 452 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT1(3), AKT2(5), AKT3(3), BCL10(1), CARD11(10), CBL(3), CBLB(4), CBLC(2), CD28(1), CD3E(2), CD3G(2), CD4(10), CD8A(1), CDC42(1), CDK4(6), CHUK(2), CTLA4(3), FOS(1), FYN(2), GRAP2(1), GRB2(2), HRAS(1), ICOS(3), IKBKB(3), IKBKG(1), IL4(1), ITK(2), JUN(2), KRAS(3), LAT(1), LCK(1), LCP2(3), MALT1(3), MAP3K14(2), MAP3K8(1), NCK1(1), NCK2(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NRAS(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDCD1(1), PDK1(1), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKCQ(5), PTPN6(3), PTPRC(8), RASGRP1(3), SOS1(9), SOS2(7), TEC(6), TNF(1), VAV1(4), VAV2(4), VAV3(1), ZAP70(1) 100777114 260 190 238 47 21 39 35 100 64 1 0.00759 1.000 1.000 453 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(7), AMY2A(1), AMY2B(2), ASCC3(6), ATP13A2(8), DDX18(4), DDX23(3), DDX4(5), DDX41(3), DDX47(3), DDX50(9), DDX51(1), DDX52(2), DDX54(3), DDX55(3), DDX56(2), DHX58(4), ENPP1(4), ENPP3(2), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(4), G6PC(3), GAA(3), GANC(3), GBA(3), GBA3(3), GBE1(2), GCK(2), GPI(3), GUSB(7), GYS1(3), GYS2(3), HK1(5), IFIH1(4), MGAM(9), MOV10L1(6), NUDT5(4), PGM1(1), PYGB(3), PYGL(2), PYGM(4), RAD54B(1), RAD54L(2), RUVBL2(3), SETX(10), SI(9), SKIV2L2(2), SMARCA2(5), SMARCA5(4), UGDH(1), UGP2(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), UXS1(1) 124157811 252 189 244 82 18 31 47 90 65 1 0.832 1.000 1.000 454 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(3), AKT2(5), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN1B(1), CDKN2A(5), CREB3(2), CREB5(3), ERBB4(11), F2RL2(2), GAB1(2), GRB2(2), GSK3A(3), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(5), IRS4(1), MET(22), MYC(2), NOLC1(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PARD3(6), PDK1(1), PIK3CA(14), PIK3CD(2), PPP1R13B(4), PREX1(8), PTEN(34), PTK2(3), PTPN1(2), RPS6KA1(8), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SOS1(9), SOS2(7), TSC1(6), TSC2(13), YWHAE(1) 75104622 236 186 218 45 21 35 38 71 65 6 0.00555 1.000 1.000 455 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(9), ATM(20), BUB1(2), BUB1B(1), BUB3(1), CCNA1(8), CCNB1(1), CCNB2(6), CCNB3(6), CCND2(1), CCNE1(3), CCNE2(4), CCNH(1), CDAN1(6), CDC14A(5), CDC14B(1), CDC20(3), CDC25A(1), CDC25B(1), CDC25C(3), CDC6(2), CDC7(2), CDH1(2), CDK2(2), CDK4(6), CDKN1A(3), CDKN2A(5), CHEK1(1), CHEK2(2), DTX4(5), E2F1(1), E2F2(1), E2F3(1), E2F5(1), EP300(16), ESPL1(13), GSK3B(3), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(3), HDAC8(1), MAD1L1(1), MAD2L1(1), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), MPEG1(1), ORC1L(1), ORC2L(1), PCNA(4), PLK1(1), PRKDC(13), PTPRA(5), PTTG2(1), RB1(4), SKP2(1), SMAD4(3), TBC1D8(1), TP53(50), WEE1(2) 111101244 275 182 253 62 27 35 41 87 78 7 0.0201 1.000 1.000 456 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), AKAP1(3), AKAP10(2), AKAP11(3), AKAP12(7), AKAP3(3), AKAP4(3), AKAP5(1), AKAP6(6), AKAP7(1), AKAP8(2), AKAP9(22), ARHGEF1(2), CALM2(1), CHMP1B(2), GNA11(1), GNA12(1), GNA13(4), GNA15(1), GNAI2(2), GNAI3(2), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(2), GNG12(2), GNG3(1), GNG7(1), HRAS(1), IL18BP(1), ITPR1(7), KCNJ3(4), KRAS(3), NRAS(2), PALM2(1), PDE1A(1), PDE1B(5), PDE1C(2), PDE4A(3), PDE4B(2), PDE4C(7), PDE4D(2), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(2), PLCB3(3), PPP3CA(3), PPP3CC(3), PRKACA(2), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(2), PRKD1(4), PRKD3(4), SLC9A1(3), USP5(4) 117000085 254 182 247 71 26 37 16 103 71 1 0.501 1.000 1.000 457 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(10), ABCA10(6), ABCA12(16), ABCA13(23), ABCA2(4), ABCA3(4), ABCA4(11), ABCA5(10), ABCA6(5), ABCA7(11), ABCA8(6), ABCA9(3), ABCB1(4), ABCB10(1), ABCB11(4), ABCB4(8), ABCB5(5), ABCB6(3), ABCB7(1), ABCB8(1), ABCB9(2), ABCC1(10), ABCC10(7), ABCC11(7), ABCC12(4), ABCC2(4), ABCC3(11), ABCC4(7), ABCC5(7), ABCC6(7), ABCC8(5), ABCC9(5), ABCD1(3), ABCD2(2), ABCD3(2), ABCD4(4), ABCG1(1), ABCG2(2), ABCG4(7), ABCG5(3), ABCG8(5), CFTR(9), TAP1(1), TAP2(1) 118313684 252 182 241 77 16 43 36 102 54 1 0.484 1.000 1.000 458 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ASIP(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3(2), CREB3L1(1), CREB3L2(1), CREB3L3(1), CREB3L4(3), CREBBP(10), CTNNB1(2), DCT(4), DVL1(1), DVL2(1), EDNRB(3), EP300(16), FZD1(4), FZD10(4), FZD2(2), FZD3(1), FZD4(4), FZD5(2), FZD7(1), GNAI1(2), GNAI2(2), GNAI3(2), GNAO1(1), GNAS(5), GSK3B(3), HRAS(1), KIT(3), KITLG(2), KRAS(3), LEF1(3), MAP2K2(1), MAPK3(3), MITF(5), NRAS(2), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), POMC(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), RAF1(4), TCF7L1(2), TCF7L2(1), TYR(5), TYRP1(4), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1) 106042160 238 178 230 62 30 29 27 99 53 0 0.190 1.000 1.000 459 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(2), ADCY8(13), ARAF(1), ATF4(2), BRAF(4), CACNA1C(18), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CREBBP(10), EP300(16), GRIA1(8), GRIA2(4), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), GRM1(5), GRM5(9), HRAS(1), ITPR1(7), ITPR2(13), ITPR3(5), KRAS(3), MAP2K2(1), MAPK3(3), NRAS(2), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PPP1R1A(1), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), RAF1(4), RAP1A(1), RAPGEF3(3), RPS6KA1(8), RPS6KA3(3), RPS6KA6(1) 100929497 230 173 216 58 31 33 25 89 50 2 0.139 1.000 1.000 460 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(3), CLK2(2), CLK3(2), CLK4(5), COL2A1(6), CPSF1(4), CPSF2(2), CPSF3(5), CPSF4(2), CSTF2T(2), CSTF3(4), DDX1(1), DDX20(7), DHX15(3), DHX16(2), DHX38(3), DHX8(3), DHX9(7), DICER1(4), FUS(6), GIPC1(3), LOC440563(2), LSM7(1), METTL3(4), NONO(2), NUDT21(1), NXF1(1), PAPOLA(4), PHF5A(1), POLR2A(13), PPM1G(2), PRPF18(2), PRPF3(2), PRPF4B(7), PRPF8(15), PSKH1(2), PTBP1(1), PTBP2(1), RBM17(3), RBM5(2), RNMT(4), RNPS1(1), SF3A1(2), SF3A3(2), SF3B1(16), SF3B2(5), SF3B4(1), SF4(1), SFRS12(1), SFRS16(1), SFRS2(1), SNRPA(1), SNRPB(3), SNRPB2(1), SNRPE(1), SNRPN(2), SPOP(1), SRPK2(2), SRRM1(5), SUPT5H(9), TXNL4A(1), U2AF2(3), XRN2(4) 105751759 211 172 206 51 18 44 22 82 44 1 0.155 1.000 1.000 461 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(3), ALG1(1), ALG10(3), ALG10B(8), ALG11(4), ALG12(2), ALG13(4), ALG14(1), ALG3(3), ALG6(3), ALG8(2), ALG9(2), B3GNT1(2), B3GNT2(3), B3GNT6(4), B3GNT7(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), B4GALT5(2), CHPF(1), CHST1(2), CHST11(1), CHST12(2), CHST14(1), CHST2(2), CHST3(2), CHST4(1), CHST6(2), CHST7(2), CHSY1(9), DPAGT1(8), EXT1(4), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), FUT11(4), GALNT1(1), GALNT10(7), GALNT11(4), GALNT13(3), GALNT14(3), GALNT2(3), GALNT4(1), GALNT5(6), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(3), HS2ST1(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(3), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), MGAT5B(4), NDST1(2), NDST2(4), NDST3(1), NDST4(7), OGT(5), RPN1(3), RPN2(1), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), UST(1), WBSCR17(6), XYLT1(5), XYLT2(2) 107807152 245 171 227 71 22 37 29 79 78 0 0.631 1.000 1.000 462 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(1), ACVR1B(4), ACVR1C(3), ACVR2A(4), ACVR2B(1), ACVRL1(1), AMHR2(9), BMP2(2), BMP4(1), BMP5(1), BMP6(1), BMP7(5), BMP8A(5), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(5), CHRD(5), CREBBP(10), CUL1(5), DCN(3), E2F5(1), EP300(16), GDF5(5), GDF6(2), GDF7(1), INHBA(2), INHBB(2), INHBC(1), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(7), MAPK3(3), MYC(2), NODAL(2), NOG(2), PITX2(2), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), RBL2(5), RBX1(1), ROCK1(5), ROCK2(4), RPS6KB1(2), RPS6KB2(2), SMAD1(1), SMAD2(2), SMAD3(2), SMAD4(3), SMAD5(1), SMAD6(1), SMAD7(1), SMAD9(1), SMURF2(4), SP1(2), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), THBS1(15), THBS2(3), THBS3(7), THBS4(4), TNF(1), ZFYVE16(1), ZFYVE9(7) 97460488 224 170 209 51 21 22 38 75 68 0 0.128 1.000 1.000 463 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(8), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(4), C1S(17), C2(2), C3(8), C3AR1(3), C4BPA(3), C4BPB(3), C5(6), C5AR1(3), C6(3), C7(4), C8A(1), C8B(2), C8G(2), CD46(1), CD55(2), CD59(1), CFB(6), CFH(6), CFI(2), CPB2(6), CR1(8), CR2(4), F10(1), F11(2), F12(7), F13A1(3), F13B(4), F2(4), F2R(2), F5(12), F7(1), F8(8), F9(2), FGA(4), FGB(2), FGG(6), KLKB1(2), KNG1(4), MASP1(4), MASP2(1), MBL2(2), PLAT(4), PLAU(5), PLAUR(2), PLG(8), PROC(4), PROS1(5), SERPINA1(3), SERPIND1(3), SERPINF2(2), SERPING1(3), TFPI(2), THBD(1), VWF(15) 90044716 237 170 216 48 24 28 25 103 55 2 0.0214 1.000 1.000 464 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(7), BAD(1), CABIN1(11), CALM2(1), CAMK2B(1), CAMK4(3), CD3E(2), CD3G(2), CDKN1A(3), CNR1(1), CREBBP(10), CSNK2A1(3), CSNK2B(1), CTLA4(3), EGR2(1), EGR3(2), EP300(16), FOS(1), GATA3(2), GATA4(2), GRLF1(6), GSK3A(3), GSK3B(3), HRAS(1), ICOS(3), IFNA1(2), IFNB1(3), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(2), JUNB(3), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(3), MEF2D(1), NCK2(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB2(3), NFKBIB(2), NPPB(1), NUP214(8), OPRD1(3), P2RX7(2), PAK1(3), PPIA(1), PPP3CC(3), PTPRC(8), RELA(6), SFN(1), SLA(1), SP1(2), SP3(2), TNF(1), TRAF2(1), TRPV6(5), VAV1(4), VAV2(4), VAV3(1), XPO5(3) 89449954 211 161 199 50 20 25 32 72 60 2 0.186 1.000 1.000 465 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(10), CD19(1), CD1A(1), CD1B(1), CD1C(2), CD1D(3), CD1E(2), CD2(2), CD22(4), CD24(1), CD33(2), CD34(2), CD36(1), CD38(1), CD3E(2), CD3G(2), CD4(10), CD44(3), CD5(1), CD55(2), CD59(1), CD8A(1), CR1(8), CR2(4), CSF1R(8), CSF2RA(5), CSF3R(4), DNTT(4), EPOR(3), FCER2(1), FCGR1A(2), FLT3(6), GP9(1), GYPA(1), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(10), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(8), IL2RA(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL7R(1), IL9R(6), ITGA1(8), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGAM(9), ITGB3(3), KIT(3), KITLG(2), MME(6), MS4A1(1), TFRC(3), THPO(1), TNF(1), TPO(4) 81530289 218 159 202 46 17 23 30 80 66 2 0.148 1.000 1.000 466 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAK1(1), BAX(1), BFAR(2), BTK(1), CAD(13), CASP10(4), CASP8(1), CASP8AP2(7), CSNK1A1(2), DAXX(6), DEDD(3), DFFA(1), DIABLO(1), EGFR(10), EPHB2(2), FAIM2(1), MAP2K7(1), MAP3K1(8), MAP3K5(5), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MET(22), NFAT5(10), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PFN2(1), PTPN13(9), RALBP1(2), RIPK1(1), ROCK1(5), SMPD1(6), TP53(50), TPX2(2), TRAF2(1) 72853538 201 157 180 38 23 24 22 75 53 4 0.00841 1.000 1.000 467 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT1(3), AKT2(5), AKT3(3), CASP8(1), CCL3(1), CD40(1), CD80(1), CD86(3), CHUK(2), CXCL11(1), CXCL9(1), FOS(1), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IKBKB(3), IKBKE(3), IKBKG(1), IL1B(1), IRAK1(3), IRAK4(1), IRF5(3), IRF7(1), JUN(2), LBP(1), LY96(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAP3K7(3), MAP3K8(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), RAC1(1), RELA(6), RIPK1(1), SPP1(3), STAT1(6), TBK1(3), TICAM1(3), TLR1(3), TLR2(2), TLR3(1), TLR4(3), TLR5(4), TLR6(2), TLR7(6), TLR8(5), TLR9(1), TNF(1), TRAF3(1), TRAF6(2) 88541992 184 150 174 39 18 28 24 83 29 2 0.0375 1.000 1.000 468 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), IMPA1(1), IMPA2(3), INPP4A(2), INPP4B(4), INPP5A(1), INPP5B(5), INPP5E(3), INPPL1(4), IPMK(1), ITPK1(2), ITPKA(2), ITPKB(2), MINPP1(2), MIOX(2), OCRL(3), PI4KA(10), PI4KB(3), PIK3C3(4), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PTEN(34), PTPMT1(2), SYNJ1(6), SYNJ2(6) 73966672 187 149 176 46 14 27 19 61 62 4 0.303 1.000 1.000 469 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(2), BRAF(4), CHUK(2), DAXX(6), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(3), JUN(2), MAP2K2(1), MAP2K3(4), MAP2K5(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K10(4), MAP3K11(2), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K6(3), MAP3K7(3), MAP3K8(1), MAP3K9(6), MAP4K1(5), MAP4K2(1), MAP4K3(6), MAP4K4(2), MAP4K5(4), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK4(2), MAPK6(1), MAPK7(4), MAPK9(2), MAPKAPK2(1), MAPKAPK5(1), MAX(5), MEF2A(3), MEF2D(1), MKNK1(2), MKNK2(1), MYC(2), NFKB1(2), NFKBIA(2), PAK1(3), PAK2(4), RAC1(1), RAF1(4), RELA(6), RIPK1(1), RPS6KA1(8), RPS6KA3(3), RPS6KA4(2), RPS6KA5(2), RPS6KB1(2), RPS6KB2(2), SHC1(4), SP1(2), STAT1(6), TGFB2(3), TGFB3(1), TGFBR1(1), TRADD(2), TRAF2(1) 95949060 201 147 189 45 20 20 23 77 57 4 0.215 1.000 1.000 470 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(20), CCNA1(8), CCNB1(1), CCND2(1), CCNE1(3), CCNE2(4), CCNG2(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(3), CDKN1B(1), CDKN2A(5), CDKN2C(1), CREB3(2), CREB3L1(1), CREB3L3(1), CREB3L4(3), E2F1(1), E2F2(1), E2F3(1), E2F5(1), GBA2(5), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), MNAT1(1), MYC(2), MYT1(5), NACA(11), ORC1L(1), ORC2L(1), PCNA(4), POLE(5), POLE2(1), PRIM1(3), RB1(4), RPA1(2), RPA2(1), RPA3(1), TFDP2(5), TNXB(11), TP53(50), WEE1(2) 75493313 211 146 187 39 22 23 24 66 70 6 0.00789 1.000 1.000 471 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT1(3), AKT2(5), AKT3(3), BCL10(1), BLNK(1), BTK(1), CARD11(10), CD19(1), CD22(4), CD72(1), CD81(1), CHUK(2), CR2(4), FOS(1), GSK3B(3), HRAS(1), IFITM1(1), IKBKB(3), IKBKG(1), INPP5D(2), JUN(2), KRAS(3), LILRB3(5), LYN(1), MALT1(3), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NRAS(2), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PTPN6(3), RAC1(1), RAC2(1), RAC3(1), RASGRP3(2), SYK(2), VAV1(4), VAV2(4), VAV3(1) 73996460 174 146 159 41 18 26 18 70 42 0 0.161 1.000 1.000 472 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(5), ACSL1(4), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), AKT1(3), AKT2(5), AKT3(3), CAMKK1(4), CAMKK2(3), CD36(1), CHUK(2), CPT1A(2), CPT1C(4), CPT2(2), G6PC(3), IKBKB(3), IKBKG(1), IRS1(5), IRS4(1), JAK1(7), JAK2(7), JAK3(4), LEP(1), LEPR(5), MAPK10(2), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NPY(1), PCK1(5), PCK2(2), POMC(2), PPARGC1A(4), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKAG1(5), PRKAG2(6), PRKAG3(1), PRKCQ(5), PTPN11(2), RELA(6), RXRB(4), RXRG(2), SLC2A1(2), SLC2A4(3), SOCS3(1), STAT3(3), STK11(3), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1), TYK2(7) 81118222 184 143 165 45 14 24 29 67 49 1 0.254 1.000 1.000 473 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), AKT1(3), AKT2(5), AKT3(3), ARHGAP1(1), ARHGEF11(5), BTK(1), CDC42(1), CFL1(1), CFL2(1), GDI2(2), INPPL1(4), ITPR1(7), ITPR2(13), ITPR3(5), LIMK1(7), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDK1(1), PIK3CA(14), PIK3CD(2), PIK3CG(4), PIK3R1(5), PITX2(2), PPP1R13B(4), PTEN(34), RACGAP1(1), RHO(1), ROCK1(5), ROCK2(4), SAG(4), WASF1(1), WASL(7) 70183324 174 139 165 33 14 36 19 53 49 3 0.0114 1.000 1.000 474 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(3), AKT2(5), AKT3(3), BAD(1), CASP9(2), CDC42(1), HRAS(1), KDR(6), KRAS(3), MAP2K2(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPKAPK2(1), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NOS3(4), NRAS(2), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKCA(2), PRKCG(6), PTGS2(5), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), SH2D2A(3), SHC2(4), SPHK1(2), SPHK2(1), SRC(4) 71174711 175 138 163 47 16 29 23 71 36 0 0.316 1.000 1.000 475 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), AKT2(5), AKT3(3), BCR(2), BTK(1), CD19(1), CDKN2A(5), DAPP1(2), FLOT1(1), FLOT2(1), GAB1(2), ITPR1(7), ITPR2(13), ITPR3(5), LYN(1), PDK1(1), PHF11(2), PIK3CA(14), PITX2(2), PLCG2(4), PPP1R13B(4), PREX1(8), PTEN(34), PTPRC(8), RPS6KA1(8), RPS6KA3(3), RPS6KB1(2), SAG(4), SYK(2), TEC(6), VAV1(4) 55409321 158 136 148 31 9 27 20 49 49 4 0.0200 1.000 1.000 476 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(3), AKT2(5), AKT3(3), BTK(1), FCER1G(1), FYN(2), GAB2(2), GRB2(2), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(3), LAT(1), LCP2(3), LYN(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK9(2), MS4A2(1), NRAS(2), PDK1(1), PIK3CA(14), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(4), PLCG2(4), PRKCA(2), PRKCD(5), PRKCE(4), RAC1(1), RAC2(1), RAC3(1), RAF1(4), SOS1(9), SOS2(7), SYK(2), TNF(1), VAV1(4), VAV2(4), VAV3(1) 72031924 155 135 146 44 14 31 23 64 23 0 0.277 1.000 1.000 477 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(5), AKT3(3), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CD22(4), CD81(1), CR2(4), CSK(4), DAG1(3), FLOT1(1), FLOT2(1), GRB2(2), GSK3A(3), GSK3B(3), INPP5D(2), ITPR1(7), ITPR2(13), ITPR3(5), LYN(1), MAP4K1(5), MAPK3(3), NFATC1(4), NFATC2(8), PDK1(1), PIK3CA(14), PIK3CD(2), PIK3R1(5), PLCG2(4), PPP1R13B(4), PPP3CA(3), PPP3CC(3), PTPRC(8), RAF1(4), SHC1(4), SOS1(9), SOS2(7), SYK(2), VAV1(4) 73169256 165 133 154 35 16 27 25 56 41 0 0.0356 1.000 1.000 478 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(4), ADAM17(2), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), CDC42(1), CHUK(2), CSK(4), CXCL1(1), EGFR(10), F11R(1), GIT1(4), IGSF5(5), IKBKB(3), IKBKG(1), JAM3(1), JUN(2), LYN(1), MAP3K14(2), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), MET(22), NFKB1(2), NFKB2(3), NFKBIA(2), NOD1(3), PAK1(3), PLCG1(4), PLCG2(4), PTPN11(2), PTPRZ1(15), RAC1(1), RELA(6), SRC(4), TCIRG1(2), TJP1(6) 70863498 164 129 151 43 15 23 22 68 34 2 0.454 1.000 1.000 479 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 67 APAF1(3), BAD(1), BAK1(1), BAX(1), BCL2L11(1), BID(2), BIRC2(3), BIRC3(5), BIRC5(1), CASP1(3), CASP10(4), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), CHUK(2), DFFA(1), DFFB(1), FAS(2), FASLG(3), HELLS(4), IKBKB(3), IKBKG(1), IRF2(2), IRF5(3), IRF6(6), IRF7(1), JUN(2), LTA(1), MAP3K1(8), MAPK10(2), MYC(2), NFKB1(2), NFKBIA(2), NFKBIB(2), PLEKHG5(1), PRF1(1), RELA(6), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TNFSF10(9), TP53(50), TP73(4), TRADD(2), TRAF2(1), TRAF3(1) 56615232 168 128 149 35 13 24 24 51 52 4 0.0446 1.000 1.000 480 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(2), APH1A(1), CREBBP(10), CTBP1(2), CTBP2(3), DLL1(1), DLL3(1), DLL4(2), DTX1(5), DTX3(1), DTX3L(2), DTX4(5), DVL1(1), DVL2(1), EP300(16), HDAC1(2), JAG1(9), JAG2(4), MAML1(9), MAML2(6), MAML3(10), NCOR2(7), NCSTN(2), NOTCH1(12), NOTCH2(13), NOTCH3(11), NOTCH4(6), NUMB(3), NUMBL(1), PSEN2(3), PSENEN(1), PTCRA(2), RBPJ(3), RBPJL(8), SNW1(3) 66065555 168 127 157 79 15 20 21 52 56 4 1.000 1.000 1.000 481 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(2), ADCY4(3), ADCY6(2), ADCY8(13), CACNA1A(14), CACNA1B(5), GNAS(5), GNB1(3), GNB3(2), GNG3(1), GRM4(6), ITPR3(5), KCNB1(2), PDE1A(1), PLCB2(4), PRKACA(2), PRKACB(5), PRKACG(3), PRKX(2), SCNN1A(4), SCNN1B(4), SCNN1G(2), TAS1R1(2), TAS1R2(9), TAS1R3(3), TAS2R1(1), TAS2R10(1), TAS2R13(2), TAS2R14(1), TAS2R16(1), TAS2R3(14), TAS2R38(4), TAS2R39(2), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R43(8), TAS2R46(2), TAS2R50(2), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(3) 56606413 153 127 142 36 33 15 17 59 29 0 0.0885 1.000 1.000 482 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(2), AASDHPPT(3), AASS(9), ACAT1(1), AKR1B10(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), BBOX1(2), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(9), GCDH(3), HADH(1), HADHA(4), HSD17B4(2), NSD1(13), OGDH(8), OGDHL(2), PIPOX(3), PLOD1(3), PLOD2(5), PLOD3(11), RDH11(4), RDH13(1), SETD1A(8), SETD7(1), SETDB1(8), SHMT1(2), SHMT2(5), SPCS1(3), SUV39H2(5), TMLHE(1) 56859555 160 126 147 32 11 26 21 56 45 1 0.0659 1.000 1.000 483 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(3), ATF2(2), CDC42(1), DLD(4), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(2), GCK(2), IL1R1(3), JUN(2), MAP2K5(4), MAP2K7(1), MAP3K1(8), MAP3K10(4), MAP3K11(2), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K7(3), MAP3K9(6), MAPK10(2), MAPK7(4), MAPK9(2), MYEF2(1), NFATC3(7), NR2C2(1), PAPPA(4), SHC1(4), TP53(50), TRAF6(2), ZAK(4) 49795709 154 125 140 31 12 19 19 58 41 5 0.0384 1.000 1.000 484 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), CAD(13), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(4), DTYMK(1), ENTPD1(1), ENTPD5(3), ENTPD6(2), NME7(2), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5M(2), PNPT1(2), POLA1(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(7), RFC5(3), RRM1(3), RRM2(1), TK1(1), TK2(2), TXNRD1(2), TXNRD2(1), TYMS(1), UCK1(1), UCK2(1), UMPS(1), UPB1(2), UPP1(2), UPP2(2), UPRT(3) 81728932 155 124 145 38 12 24 18 53 46 2 0.248 1.000 1.000 485 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(8), ATP4A(6), ATP5A1(3), ATP5B(3), ATP5C1(1), ATP5E(1), ATP5F1(1), ATP5G2(1), ATP5L(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), COX10(5), COX15(3), COX17(1), COX5A(1), COX6A2(1), COX6B2(1), COX7A1(2), COX7A2(1), COX8A(1), CYC1(1), NDUFA1(1), NDUFA10(2), NDUFA11(2), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFA7(1), NDUFB10(1), NDUFB11(1), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFC1(2), NDUFS1(7), NDUFS2(1), NDUFS3(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), NDUFV3(2), PPA2(2), SDHA(9), SDHB(1), SDHD(2), TCIRG1(2), UQCRC1(1), UQCRC2(2), UQCRFS1(2) 55948858 139 120 137 37 13 18 24 57 26 1 0.339 1.000 1.000 486 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), ASCC3(6), ATP13A2(8), DDX18(4), DDX23(3), DDX4(5), DDX41(3), DDX47(3), DDX50(9), DDX51(1), DDX52(2), DDX54(3), DDX55(3), DDX56(2), DHX58(4), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(4), FPGS(3), GGH(2), IFIH1(4), MOV10L1(6), NUDT5(4), PTS(1), QDPR(1), RAD54B(1), RAD54L(2), RUVBL2(3), SETX(10), SKIV2L2(2), SMARCA2(5), SMARCA5(4) 62195910 143 119 140 42 10 26 28 46 32 1 0.330 1.000 1.000 487 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ADORA3(2), ALG6(3), CCKBR(4), CCR2(2), CCR3(2), CCR5(1), CELSR1(18), CELSR2(9), CELSR3(10), CHRM2(6), CHRM3(3), CIDEB(2), EMR2(4), EMR3(9), F2R(2), FSHR(2), GPR116(5), GPR133(7), GPR135(2), GPR17(2), GPR18(2), GPR55(1), GPR56(1), GPR61(1), GPR77(1), GPR84(4), GRM1(5), GRPR(2), HRH4(1), LGR6(2), LPHN2(4), LPHN3(10), LTB4R2(1), NTSR1(3), OR8G1(2), OR8G2(2), P2RY13(1), PTGFR(5), SMO(4), SSTR2(2), TSHR(2) 64070642 151 118 145 48 23 21 17 59 31 0 0.604 1.000 1.000 488 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(3), ACADL(3), ACADM(1), ACOX1(2), ACOX2(2), ACOX3(5), ACSL1(4), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), ANGPTL4(3), APOA1(1), APOA2(1), APOA5(2), AQP7(10), CD36(1), CPT1A(2), CPT1C(4), CPT2(2), CYP27A1(1), CYP4A11(5), CYP4A22(2), CYP8B1(3), DBI(1), EHHADH(6), FABP1(3), FABP3(1), FADS2(2), GK(1), GK2(3), HMGCS2(1), ILK(4), LPL(3), ME1(1), MMP1(2), NR1H3(3), PCK1(5), PCK2(2), PLTP(2), PPARD(1), PPARG(2), RXRB(4), RXRG(2), SCP2(3), SLC27A1(4), SLC27A2(1), SLC27A5(3), SLC27A6(7), SORBS1(3), UBC(4), UCP1(1) 64574096 152 118 135 46 12 20 17 65 37 1 0.741 1.000 1.000 489 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(3), CALR(2), CANX(2), CD4(10), CD74(1), CD8A(1), CIITA(5), CTSB(4), CTSL1(3), CTSS(1), HLA-A(6), HLA-B(10), HLA-C(10), HLA-DOA(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(10), HLA-E(2), HLA-F(2), HSP90AA1(6), HSP90AB1(7), HSPA5(2), IFI30(1), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), KIR2DL1(1), KIR2DL3(1), KIR2DL4(1), KIR2DS4(1), KIR3DL1(3), KIR3DL2(1), KIR3DL3(3), KLRC1(3), KLRC2(5), KLRC3(1), LTA(1), NFYA(1), NFYC(2), PSME2(3), RFX5(2), RFXAP(1), TAP1(1), TAP2(1) 43001311 156 118 148 52 8 26 17 63 40 2 0.914 1.000 1.000 490 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(18), B3GALT4(1), CDR1(4), DGKI(1), FAU(3), IL6ST(6), PIGK(1), RPL10(1), RPL11(3), RPL13(1), RPL14(1), RPL18(3), RPL18A(2), RPL19(2), RPL21(1), RPL22(3), RPL23(1), RPL24(1), RPL26(1), RPL27(2), RPL28(1), RPL3(3), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL38(1), RPL3L(3), RPL4(2), RPL5(3), RPL6(1), RPL7(1), RPL7A(3), RPL8(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(2), RPS19(1), RPS2(2), RPS21(2), RPS24(2), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(8), RPS6KA3(3), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), RPS7(1), RPS8(1), RPS9(1), RPSA(1), SLC36A2(2), TBC1D10C(2), TSPAN9(1), UBA52(1), UBB(1), UBC(4) 51762032 132 117 124 34 9 13 26 47 35 2 0.438 1.000 1.000 491 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(2), BMP4(1), BMP5(1), BMP6(1), BMP7(5), BMP8A(5), BMP8B(1), BTRC(2), CSNK1A1(2), CSNK1E(3), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), FBXW11(2), GLI1(7), GLI2(4), GLI3(7), GSK3B(3), HHIP(3), IHH(1), LRP2(25), PRKACA(2), PRKACB(5), PRKACG(3), PRKX(2), PTCH1(11), PTCH2(2), SHH(3), SMO(4), STK36(2), SUFU(3), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1), ZIC2(1) 57935422 140 116 129 41 18 18 14 52 38 0 0.696 1.000 1.000 492 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(4), CPEB1(3), EGFR(10), ERBB2(8), ERBB4(11), ETS1(2), ETS2(1), ETV6(2), FMN2(9), GRB2(2), KRAS(3), MAPK3(3), NOTCH1(12), NOTCH2(13), NOTCH3(11), NOTCH4(6), PIWIL1(2), PIWIL2(2), PIWIL3(4), PIWIL4(3), RAF1(4), SOS1(9), SOS2(7), SPIRE1(1), SPIRE2(2) 50297264 134 113 130 37 21 15 20 47 28 3 0.458 1.000 1.000 493 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(2), APOA1(1), APOA2(1), CD36(1), CITED2(1), CREBBP(10), EHHADH(6), EP300(16), FABP1(3), HSD17B4(2), INS(1), JUN(2), LPL(3), MAPK3(3), ME1(1), MRPL11(1), MYC(2), NCOA1(4), NCOR1(7), NCOR2(7), NFKBIA(2), NR1H3(3), NR2F1(1), NRIP1(7), PIK3CA(14), PIK3R1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PTGS2(5), RB1(4), RELA(6), SP1(2), SRA1(1), STAT5A(3), STAT5B(3), TNF(1) 62570772 147 112 133 47 8 25 18 54 39 3 0.788 1.000 1.000 494 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AGK(6), AGPAT1(1), AGPAT6(1), AKR1A1(2), AKR1B1(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), CEL(3), DAK(3), DGAT1(2), DGAT2(1), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), GK(1), GK2(3), GLA(1), GLB1(5), GPAM(5), LCT(7), LIPA(1), LIPC(1), LIPF(1), LPL(3), PNLIP(4), PNLIPRP2(1), PNPLA3(3), PPAP2B(1), PPAP2C(3) 58826635 126 108 123 32 14 18 18 46 30 0 0.222 1.000 1.000 495 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(3), ASAH1(3), ATF1(2), BRAF(4), CAMP(1), CREB3(2), CREB5(3), CREBBP(10), CRKL(1), DAG1(3), EGR1(10), EGR2(1), EGR3(2), EGR4(1), ELK1(1), FRS2(2), JUN(2), MAP1B(12), MAP2K7(1), MAPK10(2), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), NTRK1(8), PIK3C2G(5), PIK3CA(14), PIK3CD(2), PIK3R1(5), PTPN11(2), RPS6KA3(3), SHC1(4), SRC(4), TH(4) 50743771 129 108 115 32 16 29 15 40 28 1 0.134 1.000 1.000 496 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(4), ACSS2(7), ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDH7A1(1), ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GALM(3), GAPDH(4), GAPDHS(5), GCK(2), GPI(3), HK1(5), LDHAL6B(1), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKL(3), PFKM(3), PFKP(3), PGAM1(1), PGAM2(2), PGK1(3), PGK2(1), PGM1(1), PKLR(1), PKM2(1), TPI1(2) 57844581 129 106 119 35 11 9 19 44 44 2 0.613 1.000 1.000 497 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(2), ABP1(5), ACAT1(1), ACMSD(2), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(2), AOX1(8), CAT(2), CYP1A1(1), CYP1A2(4), CYP1B1(2), DDC(3), ECHS1(3), EHHADH(6), GCDH(3), HAAO(2), HADH(1), HADHA(4), HSD17B4(2), KYNU(3), LCMT1(1), LCMT2(4), LNX1(1), MAOA(2), MAOB(2), METTL2B(1), NFX1(3), OGDH(8), OGDHL(2), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), TPH1(2), TPH2(2), WARS(1), WARS2(4) 60265649 124 105 117 30 10 20 23 44 27 0 0.165 1.000 1.000 498 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(3), APAF1(3), ARHGDIB(1), BAG4(1), BID(2), BIRC2(3), BIRC3(5), CASP2(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DAXX(6), DFFA(1), DFFB(1), GSN(5), LMNB1(3), LMNB2(1), MAP2K7(1), MAP3K1(8), MAP3K14(2), MAP3K5(5), NFKB1(2), NFKBIA(2), NUMA1(7), PAK2(4), PRKCD(5), PRKDC(13), PSEN2(3), PTK2(3), RASA1(7), RB1(4), RELA(6), RIPK1(1), SPTAN1(12), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1) 69400667 134 104 131 39 6 26 19 42 38 3 0.565 1.000 1.000 499 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(10), EEF1A2(3), EEF1B2(3), EEF1D(2), EEF1G(2), EEF2(2), EEF2K(4), EIF1AX(1), EIF2AK1(5), EIF2AK2(4), EIF2AK3(3), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF4A1(1), EIF4A2(4), EIF4E(2), EIF4EBP1(1), EIF4G1(5), EIF4G3(7), EIF5(3), EIF5A(2), EIF5B(2), ETF1(3), GSPT2(1), KIAA0664(3), PABPC1(18), PABPC3(17), PAIP1(3), SLC35A4(2) 43920888 124 103 118 38 15 23 21 38 24 3 0.448 1.000 1.000 500 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(9), AXIN1(5), CCND2(1), CSNK1E(3), CTNNB1(2), DVL1(1), DVL2(1), FZD1(4), FZD10(4), FZD2(2), FZD3(1), FZD5(2), FZD7(1), GSK3B(3), JUN(2), LDLR(3), MAPK10(2), MAPK9(2), MYC(2), PAFAH1B1(1), PLAU(5), PPP2R5C(3), PPP2R5E(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(2), PRKD1(4), RAC1(1), SFRP4(2), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT5B(2), WNT7B(1) 57268066 118 103 114 31 15 17 11 42 33 0 0.276 1.000 1.000 501 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(5), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1A3(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), AOX1(8), DBH(2), DCT(4), DDC(3), ECH1(2), ESCO1(2), ESCO2(1), FAH(1), GOT1(3), GOT2(2), HGD(3), HPD(2), LCMT1(1), LCMT2(4), MAOA(2), MAOB(2), METTL2B(1), MYST3(4), MYST4(3), PNPLA3(3), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SH3GLB1(3), TAT(2), TH(4), TPO(4), TYR(5), TYRP1(4) 58823389 123 102 119 29 13 12 18 48 32 0 0.266 1.000 1.000 502 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 42 APAF1(3), BAK1(1), BAX(1), BID(2), BIRC2(3), BIRC3(5), CASP2(1), CASP7(1), CASP8(1), CASP9(2), FAS(2), FASLG(3), IKBKG(1), JUN(2), MAP3K1(8), MAP3K14(2), MAPK10(2), MYC(2), NFKB1(2), NFKBIA(2), PARP1(5), PRF1(1), RELA(6), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF10(9), TP53(50), TRADD(2), TRAF2(1) 37121383 124 101 109 30 7 20 17 36 40 4 0.223 1.000 1.000 503 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(5), AKT3(3), ASAH1(3), BRAF(4), DAG1(3), DRD2(1), EGFR(10), EPHB2(2), GRB2(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), KCNJ3(4), PI3(1), PIK3CB(5), PITX2(2), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), RAF1(4), RGS20(1), SHC1(4), SOS1(9), SOS2(7), SRC(4), STAT3(3) 58297991 127 101 125 30 13 19 22 47 25 1 0.123 1.000 1.000 504 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1C1(1), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH1A3(3), ALDH3B1(4), ALDH3B2(3), CYP1A1(1), CYP1A2(4), CYP1B1(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2F1(4), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHDH(6), EPHX1(6), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM1(3), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6) 57730669 123 100 119 35 15 11 20 46 31 0 0.549 1.000 1.000 505 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT1(1), AGPAT6(1), CDS2(2), CHAT(5), CHKB(2), CHPT1(3), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), ESCO1(2), ESCO2(1), ETNK1(3), ETNK2(1), GPAM(5), GPD1(1), GPD1L(3), GPD2(1), LCAT(5), LYPLA1(1), MYST3(4), MYST4(3), PCYT1A(1), PCYT1B(1), PISD(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(7), PNPLA3(3), PPAP2B(1), PPAP2C(3), PTDSS1(2), SH3GLB1(3) 65536580 117 94 112 31 16 15 15 39 32 0 0.313 1.000 1.000 506 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(5), ACAT1(1), ACMSD(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), AOC2(5), AOC3(2), AOX1(8), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(3), CYP3A5(1), CYP3A7(2), CYP4B1(4), CYP4F8(1), CYP51A1(2), DDC(3), ECHS1(3), EHHADH(6), GCDH(3), HAAO(2), HADHA(4), KYNU(3), MAOA(2), MAOB(2), TPH1(2), WARS(1), WARS2(4) 54712976 122 94 115 31 16 16 16 51 23 0 0.234 1.000 1.000 507 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALNT1(1), B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GALT5(3), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALNT1(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), B4GALT6(1), FUT1(1), FUT2(2), FUT3(2), FUT4(2), FUT6(4), FUT7(1), GBGT1(2), GCNT2(22), PIGB(2), PIGC(1), PIGF(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(3), PIGO(5), PIGP(1), PIGQ(6), PIGS(2), PIGT(6), PIGU(1), PIGV(1), PIGZ(3), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1) 47664340 118 93 96 31 14 15 11 31 46 1 0.660 1.000 1.000 508 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(5), ALAS2(5), BLVRA(1), COX10(5), COX15(3), CP(4), CPOX(6), EPRS(5), FECH(2), FTMT(5), GUSB(7), HCCS(1), HMOX1(3), HMOX2(1), MMAB(1), PPOX(2), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), UROD(2) 42004357 104 92 96 31 10 9 17 42 26 0 0.722 1.000 1.000 509 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(7), AMY2A(1), AMY2B(2), ENPP1(4), ENPP3(2), G6PC(3), GAA(3), GBA3(3), GBE1(2), GCK(2), GPI(3), GUSB(7), GYS1(3), GYS2(3), HK1(5), MGAM(9), PGM1(1), PYGB(3), PYGL(2), PYGM(4), RNPC3(1), SI(9), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4), UXS1(1) 57501205 109 92 104 35 11 10 19 40 29 0 0.780 1.000 1.000 510 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), CALM2(1), ELK1(1), FCER1G(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP2K7(1), MAP3K1(8), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PAK2(4), PIK3CA(14), PIK3R1(5), PLA2G4A(2), PLCG1(4), PPP3CA(3), PPP3CC(3), RAF1(4), SHC1(4), SOS1(9), SYK(2), SYT1(1), VAV1(4) 42262344 104 91 96 30 10 18 11 36 29 0 0.573 1.000 1.000 511 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(2), DAXX(6), EGF(5), EGFR(10), ETS1(2), ETS2(1), FOS(1), HOXA7(1), HRAS(1), IKBKB(3), JUN(2), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K14(2), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(3), NFKB1(2), NFKBIA(2), PPP2CA(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), RAF1(4), RELA(6), RIPK1(1), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(1) 48453273 108 90 102 27 14 11 5 41 36 1 0.584 1.000 1.000 512 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(9), ACTB(7), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(2), EZR(2), FYN(2), HCLS1(1), ITGB1(7), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(2), ROCK1(5), ROCK2(4), TLR4(3), TLR5(4), TUBA1A(3), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB8(4), WAS(1), WASL(7) 50890196 111 87 110 49 13 23 23 31 21 0 0.971 1.000 1.000 513 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(9), ACTB(7), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(2), EZR(2), FYN(2), HCLS1(1), ITGB1(7), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(2), ROCK1(5), ROCK2(4), TLR4(3), TLR5(4), TUBA1A(3), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB8(4), WAS(1), WASL(7) 50890196 111 87 110 49 13 23 23 31 21 0 0.971 1.000 1.000 514 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(6), BCR(2), CAPN1(3), CRKL(1), CSK(4), FYN(2), GRB2(2), HRAS(1), ITGA1(8), ITGB1(7), JUN(2), MAP2K2(1), MAPK3(3), PPP1R12B(2), PTK2(3), PXN(3), RAF1(4), RAP1A(1), ROCK1(5), SHC1(4), SOS1(9), SRC(4), TLN1(14), VCL(2), ZYX(1) 46700891 100 87 99 27 8 14 8 45 24 1 0.566 1.000 1.000 515 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(5), AGMAT(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH4A1(2), AMD1(2), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(6), DAO(1), GATM(2), GOT1(3), GOT2(2), MAOA(2), MAOB(2), NOS1(10), NOS3(4), OAT(2), ODC1(2), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), P4HB(2), PYCR1(1), RARS(3), SMS(2) 43864785 96 86 94 28 8 7 20 35 25 1 0.618 1.000 1.000 516 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AGPAT1(1), AKR1A1(2), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), CEL(3), DGAT1(2), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), GK(1), GLA(1), GLB1(5), LCT(7), LIPC(1), LIPF(1), LPL(3), PNLIP(4), PNLIPRP2(1), PPAP2B(1), PPAP2C(3) 48269350 102 86 99 30 14 15 13 35 25 0 0.488 1.000 1.000 517 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(5), AGXT(2), AGXT2(2), ALAS1(5), ALAS2(5), AOC2(5), AOC3(2), BHMT(7), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(5), GATM(2), GLDC(4), MAOA(2), MAOB(2), PISD(2), PLCB2(4), PLCG1(4), PLCG2(4), SARDH(5), SARS(3), SHMT1(2), SHMT2(5), TARS(6) 41967764 96 86 92 26 10 14 18 31 22 1 0.347 1.000 1.000 518 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT1(3), AKT2(5), AKT3(3), ARHGEF11(5), CDC42(1), DLG4(2), GNA13(4), IKBKG(1), LPA(9), MAP3K1(8), MAP3K5(5), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PI3(1), PIK3CB(5), PLD1(3), PLD2(7), PLD3(3), PTK2(3), RDX(2), ROCK1(5), ROCK2(4), SRF(1), TBXA2R(4) 48951973 101 86 97 30 13 12 12 42 22 0 0.590 1.000 1.000 519 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(4), GCK(2), GPI(3), HK1(5), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGAM1(1), PGK1(3), PGM1(1), PKLR(1), PKM2(1), TPI1(2) 48536050 103 85 95 32 10 5 15 38 34 1 0.836 1.000 1.000 520 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(4), GCK(2), GPI(3), HK1(5), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGAM1(1), PGK1(3), PGM1(1), PKLR(1), PKM2(1), TPI1(2) 48536050 103 85 95 32 10 5 15 38 34 1 0.836 1.000 1.000 521 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(9), COL4A6(7), F10(1), F11(2), F12(7), F2(4), F2R(2), F5(12), F8(8), F9(2), FGA(4), FGB(2), FGG(6), KLKB1(2), PROC(4), PROS1(5), SERPING1(3) 44687494 96 85 94 30 12 17 10 34 22 1 0.482 1.000 1.000 522 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(3), CARS(6), CARS2(3), DARS(3), DARS2(1), EPRS(5), FARSA(2), HARS(1), HARS2(1), IARS(4), IARS2(4), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(4), MTFMT(1), NARS2(6), PARS2(3), QARS(1), RARS(3), RARS2(2), SARS(3), SARS2(1), TARS(6), TARS2(7), VARS(4), VARS2(6), WARS(1), WARS2(4), YARS(1), YARS2(1) 53298830 103 84 97 29 3 16 11 47 26 0 0.607 1.000 1.000 523 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(4), GAPDHS(5), GCK(2), GOT1(3), GOT2(2), GPI(3), HK1(5), LDHAL6B(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), PC(8), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PDHX(2), PFKL(3), PFKM(3), PFKP(3), PGAM1(1), PGAM2(2), PGK1(3), PGK2(1), PKLR(1), PKM2(1), TNFAIP1(1), TPI1(2) 41944124 100 83 95 29 6 8 14 28 43 1 0.711 1.000 1.000 524 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(2), CDK2(2), CDT1(2), DIAPH2(2), MCM10(4), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), NACA(11), ORC1L(1), ORC2L(1), PCNA(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), PRIM1(3), RFC1(6), RFC2(1), RFC4(2), RFC5(3), RPA1(2), RPA2(1), RPA3(1), RPA4(2), RPS27A(1), UBA52(1), UBB(1), UBC(4) 50721121 99 82 90 30 11 10 11 36 31 0 0.759 1.000 1.000 525 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(2), F12(7), F13B(4), F2(4), F5(12), F7(1), F8(8), F9(2), FGA(4), FGB(2), FGG(6), LPA(9), PLAT(4), PLAU(5), PLG(8), SERPINB2(1), SERPINF2(2), VWF(15) 34880438 97 81 93 33 9 9 16 35 26 2 0.771 1.000 1.000 526 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT1(1), AGPS(5), CDS2(2), CHAT(5), CHKB(2), CLC(2), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), ETNK1(3), GPD1(1), GPD2(1), LCAT(5), LGALS13(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(2), PCYT1A(1), PCYT1B(1), PISD(2), PLA2G4A(2), PLA2G6(5), PLCB2(4), PLCG1(4), PLCG2(4), PPAP2B(1), PPAP2C(3) 49908150 95 81 91 27 15 16 10 29 25 0 0.346 1.000 1.000 527 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), ARSD(3), ARSE(2), CYP11B1(3), CYP11B2(2), CYP19A1(2), HSD11B2(1), HSD17B1(1), HSD17B2(1), HSD17B7(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SRD5A1(1), SULT1E1(2), SULT2A1(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6) 49477840 89 80 89 26 7 7 19 29 27 0 0.559 1.000 1.000 528 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(8), ACACB(5), ACAT1(1), ACOT12(1), ACSS1(4), ACSS2(7), ACYP1(1), AKR1B1(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), DLAT(2), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(5), PCK2(2), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1), PKM2(1) 46455859 93 79 89 26 5 12 18 24 32 2 0.634 1.000 1.000 529 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(3), ACTG2(1), ACTR2(2), AKT1(3), CDC42(1), CFL1(1), CFL2(1), FLNA(6), FLNC(10), FSCN1(4), FSCN2(1), FSCN3(2), GDI2(2), LIMK1(7), MYH2(9), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PFN2(1), RHO(1), ROCK1(5), ROCK2(4), WASF1(1), WASL(7) 46819765 96 79 93 31 9 21 5 31 30 0 0.740 1.000 1.000 530 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), AKT1(3), DAG1(3), DGKA(4), GCA(3), ITGA9(3), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), MAPK3(3), NR1I3(1), PAK1(3), PDE3A(4), PDE3B(3), PI3(1), PIK3C2G(5), PIK3CA(14), PIK3CD(2), PIK3R1(5) 48967400 88 79 83 25 8 19 10 37 14 0 0.370 1.000 1.000 531 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP4A(2), INPP4B(4), INPP5A(1), INPPL1(4), ITPKA(2), ITPKB(2), MIOX(2), OCRL(3), PIK3C2A(6), PIK3C2B(6), PIK3C2G(5), PIK3CA(14), PIK3CB(5), PIK3CG(4), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCG1(4), PLCG2(4) 45078568 90 77 83 26 6 14 7 40 23 0 0.694 1.000 1.000 532 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AGTR2(1), ATP8A1(2), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), CCKAR(4), CCKBR(4), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), CXCR6(1), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR77(1), GRPR(2), MC2R(3), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(2), NPY2R(2), NTSR1(3), OPRD1(3), OPRK1(2), OPRM1(3), OXTR(1), SSTR1(4), SSTR2(2), SSTR3(2), SSTR4(3), TACR1(2), TACR2(2), TACR3(2), TRHR(2), TSHR(2) 50346108 93 77 93 34 18 11 12 39 13 0 0.641 1.000 1.000 533 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(3), APC(9), ASAH1(3), CAMP(1), CAV3(1), DAG1(3), DLG4(2), EPHB2(2), GNAI1(2), ITPR1(7), ITPR2(13), ITPR3(5), KCNJ3(4), PITX2(2), RAC1(1), RHO(1), RYR1(23) 45473864 82 77 82 20 14 11 15 29 13 0 0.160 1.000 1.000 534 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(3), BTG1(3), CBX3(1), CLOCK(4), CRY1(1), EIF4G2(4), ETV6(2), GSTP1(2), HERPUD1(3), HSPA8(8), IDI1(1), KLF9(2), MYF6(3), NCKAP1(3), NCOA4(7), NR1D2(2), PER1(6), PER2(6), PIGF(1), PPP1R3C(1), PPP2CB(2), PSMA4(2), SF3A3(2), TOB1(5), TUBB3(3), UGP2(1), ZFR(8) 36283558 86 76 85 28 4 12 17 32 19 2 0.747 1.000 1.000 535 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(3), ALOX12B(2), ALOX15B(3), ALOX5(4), CBR1(4), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(3), CYP2U1(1), CYP4A11(5), CYP4A22(2), CYP4F2(4), CYP4F3(2), DHRS4(3), EPHX2(1), GGT1(4), GPX1(2), GPX3(3), GPX4(2), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4) 38801290 84 76 81 21 10 9 18 31 15 1 0.225 1.000 1.000 536 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(9), CREBBP(10), EP300(16), ERCC3(4), GRIP1(3), GTF2A1(2), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(3), NCOR2(7), NRIP1(7), PELP1(1), POLR2A(13), SRA1(1), TBP(1) 46262931 85 75 81 45 6 10 14 31 24 0 0.998 1.000 1.000 537 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(3), AKR1B10(3), ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), FPGT(1), FUK(2), GMDS(2), GMPPA(2), GMPPB(3), HK1(5), KHK(8), MPI(2), MTMR1(2), MTMR2(3), MTMR6(1), PFKFB3(4), PFKFB4(1), PFKL(3), PFKM(3), PFKP(3), PGM2(2), PHPT1(1), PMM1(2), RDH11(4), RDH13(1), SORD(10), TPI1(2) 37171158 81 75 74 21 11 8 13 24 25 0 0.458 1.000 1.000 538 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(5), AKT3(3), ANKRD6(2), APC(9), AXIN1(5), AXIN2(1), CER1(1), CSNK1A1(2), CTNNB1(2), DACT1(2), DKK2(1), DVL1(1), FSTL1(2), GSK3A(3), GSK3B(3), LRP1(15), MVP(5), NKD1(4), NKD2(4), PTPRA(5), SENP2(1), WIF1(5) 40007373 84 75 79 21 7 12 12 31 22 0 0.283 1.000 1.000 539 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(8), ACACB(5), ACADM(1), ACAT1(1), ACSS1(4), ACSS2(7), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), ECHS1(3), EHHADH(6), HADHA(4), HIBCH(1), LDHAL6B(1), LDHB(2), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(3), SUCLA2(2), SUCLG1(5), SUCLG2(2) 39835717 83 73 78 22 4 10 22 23 22 2 0.415 1.000 1.000 540 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(9), AR(5), ESR2(4), ESRRA(1), HNF4A(2), NR1D2(2), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(1), NR2F2(4), NR2F6(1), NR3C1(4), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(2), PGR(5), PPARD(1), PPARG(2), RARA(4), RARB(3), RARG(1), RORA(3), RORC(2), RXRB(4), RXRG(2), THRA(2), VDR(2) 40701245 77 73 76 26 10 13 16 27 11 0 0.612 1.000 1.000 541 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(1), CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP3K1(8), MAPK14(1), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), RAC1(1), RAF1(4), SHC1(4), SOS1(9), SYK(2), SYT1(1), VAV1(4) 37521064 82 72 79 26 9 11 9 27 26 0 0.792 1.000 1.000 542 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG1(1), ARG2(1), ASL(4), ASS1(3), CKB(1), CKMT1B(1), CPS1(6), DAO(1), EPRS(5), GATM(2), GLUD2(7), GOT1(3), GOT2(2), LAP3(4), NOS1(10), NOS3(4), OAT(2), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), PARS2(3), PRODH(4), PYCR1(1), PYCR2(1), RARS(3), RARS2(2) 35757050 81 72 79 23 8 6 17 32 18 0 0.502 1.000 1.000 543 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ABAT(1), ACADS(3), ACAT1(1), ACSM1(3), AKR1B10(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADH(1), HADHA(4), HMGCL(1), HMGCS1(2), HMGCS2(1), HSD17B4(2), ILVBL(3), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(3), PRDX6(2), RDH11(4), RDH13(1) 40674438 77 71 73 23 9 11 14 27 16 0 0.517 1.000 1.000 544 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAD(1), BAX(1), BCL2A1(2), CASP1(3), CASP10(4), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), CD40(1), DAXX(6), DFFA(1), DFFB(1), FAS(2), FASLG(3), IKBKE(3), LTA(1), NFKB1(2), NFKBIA(2), NGFR(1), NR3C1(4), NTRK1(8), PTPN13(9), RIPK1(1), TFG(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2) 43389187 78 69 77 20 5 14 15 30 14 0 0.312 1.000 1.000 545 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(4), CASP7(1), CASP8(1), CFLAR(1), DAXX(6), DFFA(1), DFFB(1), JUN(2), LMNB1(3), LMNB2(1), MAP3K1(8), MAP3K7(3), PAK1(3), PAK2(4), PRKDC(13), PTPN13(9), RB1(4), RIPK2(4), SPTAN1(12) 42361490 82 69 82 25 6 9 12 29 23 3 0.739 1.000 1.000 546 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(2), CALM2(1), ELK1(1), FOS(1), GNAI1(2), GNAS(5), GNB1(3), HRAS(1), JUN(2), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), RAF1(4), RPS6KA3(3), SYT1(1) 33890354 77 69 74 23 11 8 6 29 23 0 0.749 1.000 1.000 547 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(2), AKT1(3), ASAH1(3), GNAI1(2), GNB1(3), ITGAV(1), ITGB3(3), MAPK3(3), PDGFRA(8), PIK3CA(14), PIK3R1(5), PLCB1(4), PRKCA(2), PTK2(3), RAC1(1), SMPD1(6), SMPD2(3), SPHK1(2), SRC(4) 27332016 72 68 66 21 8 18 6 27 13 0 0.444 1.000 1.000 548 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(4), B4GALT5(2), GALNT1(1), GALNT10(7), GALNT11(4), GALNT13(3), GALNT14(3), GALNT2(3), GALNT4(1), GALNT5(6), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(3), OGT(5), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(6) 32403597 74 68 70 27 6 8 16 25 19 0 0.860 1.000 1.000 549 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), ERCC3(4), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F2(1), GTF2H1(2), GTF2H2(2), GTF2H4(1), ILK(4), MNAT1(1), POLR1A(6), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3B(5), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(2), TAF7(2), TBP(1) 35228221 74 68 69 21 5 7 8 30 24 0 0.655 1.000 1.000 550 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10(3), ALG10B(8), ALG11(4), ALG12(2), ALG13(4), ALG14(1), ALG3(3), ALG5(2), ALG6(3), ALG8(2), ALG9(2), B4GALT1(1), B4GALT3(2), DOLPP1(3), DPAGT1(8), DPM1(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), MGAT5B(4), RFT1(2), RPN1(3), RPN2(1), ST6GAL1(1), STT3B(4) 42113922 82 67 81 20 4 19 4 28 27 0 0.347 1.000 1.000 551 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(8), ACAT1(1), ACYP1(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), DLAT(2), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1), PKM2(1) 36714968 75 66 72 21 4 9 14 22 25 1 0.617 1.000 1.000 552 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFA(1), DFFB(1), JUN(2), LMNB1(3), LMNB2(1), MADD(9), MAP3K1(8), MAP3K7(3), PAK1(3), PAK2(4), PRKDC(13), RB1(4), RIPK1(1), SPTAN1(12), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 39344213 74 65 74 25 3 10 12 24 22 3 0.835 1.000 1.000 553 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(3), ARSE(2), ASAH1(3), B4GALT6(1), CERK(6), DEGS1(2), DEGS2(1), ENPP7(2), GAL3ST1(4), GALC(3), GBA(3), GLA(1), GLB1(5), LCT(7), NEU1(1), PPAP2B(1), PPAP2C(3), SGMS1(1), SGPP1(2), SGPP2(2), SMPD1(6), SMPD2(3), SMPD4(2), SPHK1(2), SPHK2(1), SPTLC1(1), SPTLC2(2), UGT8(2) 34445146 74 64 70 25 13 13 7 25 16 0 0.635 1.000 1.000 554 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(3), AKR1B10(3), B4GALT1(1), G6PC(3), GAA(3), GALE(2), GALK1(1), GALK2(2), GALT(3), GANC(3), GCK(2), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(7), MGAM(9), PFKL(3), PFKM(3), PFKP(3), PGM1(1), RDH11(4), RDH13(1), UGP2(1) 38163708 70 62 69 27 10 8 9 24 19 0 0.911 1.000 1.000 555 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(3), ACTG2(1), ADCY3(7), ADCY9(7), ARF1(1), ARF3(3), ARF5(1), ARF6(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(4), ATP6V1D(1), ATP6V1G1(1), ERO1L(1), GNAS(5), PDIA4(1), PLCG1(4), PLCG2(4), PRKCA(2), SEC61B(2), TRIM23(5) 36995340 68 61 66 26 5 7 9 30 17 0 0.958 1.000 1.000 556 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(6), CXCR4(1), GNAI1(2), GNB1(3), HRAS(1), MAPK3(3), NFKB1(2), PIK3C2G(5), PIK3CA(14), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(3), PTK2B(3), PXN(3), RAF1(4), RELA(6) 27999113 67 60 58 24 4 15 7 24 15 2 0.893 1.000 1.000 557 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BID(2), BIRC2(3), BIRC3(5), CASP10(4), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DFFA(1), DFFB(1), GAS2(4), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), SPTAN1(12), TNFRSF10B(1), TNFRSF25(1), TNFSF10(9), TRADD(2), TRAF2(1) 33337320 69 60 63 18 3 9 11 24 21 1 0.527 1.000 1.000 558 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(3), MRPL13(1), MRPS7(2), RPL10A(2), RPL11(3), RPL13(1), RPL14(1), RPL18(3), RPL18A(2), RPL19(2), RPL21(1), RPL22L1(1), RPL24(1), RPL26(1), RPL27(2), RPL28(1), RPL3(3), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL36AL(1), RPL38(1), RPL3L(3), RPL6(1), RPL7(1), RPL8(1), RPS11(1), RPS13(1), RPS2(2), RPS21(2), RPS24(2), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS7(1), RPS8(1), RPS9(1), RPSA(1) 22043805 63 59 63 17 5 6 11 26 14 1 0.570 1.000 1.000 559 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(6), CALM2(1), CRKL(1), GRB2(2), HRAS(1), JUN(2), MAP2K2(1), MAP2K3(4), MAP3K1(8), MAPK14(1), MAPK3(3), PAK1(3), PLCG1(4), PRKCA(2), PTK2B(3), RAC1(1), RAF1(4), SHC1(4), SOS1(9), SRC(4), SYT1(1) 28336172 65 59 64 21 5 12 4 27 16 1 0.853 1.000 1.000 560 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(2), BCR(2), BLNK(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP3K1(8), MAPK3(3), MAPK8IP3(2), PAPPA(4), RAC1(1), RPS6KA1(8), RPS6KA3(3), SHC1(4), SOS1(9), SYK(2), VAV1(4), VAV2(4), VAV3(1) 31619373 66 59 61 18 6 11 8 24 16 1 0.457 1.000 1.000 561 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(1), ACTN2(3), ACTN3(1), CAPN1(3), ITGA1(8), ITGB1(7), ITGB3(3), PTK2(3), PXN(3), RAC1(1), SPTAN1(12), SRC(4), TLN1(14) 28528464 64 59 63 20 5 9 5 27 18 0 0.775 1.000 1.000 562 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CHUK(2), ELK1(1), FOS(1), IKBKB(3), IKBKG(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAP3K14(2), MAP3K7(3), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TLR10(3), TLR2(2), TLR3(1), TLR4(3), TLR6(2), TLR7(6), TLR9(1), TRAF6(2) 36225584 63 57 59 18 6 10 4 24 17 2 0.632 1.000 1.000 563 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(3), ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), FPGT(1), GCK(2), GMDS(2), GMPPA(2), GMPPB(3), HK1(5), KHK(8), MPI(2), PFKFB3(4), PFKFB4(1), PFKM(3), PFKP(3), PMM1(2), SORD(10), TPI1(2) 23916050 61 56 54 19 6 4 10 17 24 0 0.862 1.000 1.000 564 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(10), BAIAP2(2), CASP1(3), CASP7(1), CASP8(1), GAPDH(4), INS(1), INSR(6), MAGI1(5), MAGI2(6), RERE(10), WWP1(8), WWP2(4) 23569036 61 56 52 24 8 4 7 21 19 2 0.992 1.000 1.000 565 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), ATF1(2), CDC42(1), CREB3(2), CREB5(3), DUSP10(1), EEF2K(4), EIF4E(2), ELK1(1), IL1R1(3), MAP2K3(4), MAP2K6(1), MAP3K10(4), MAP3K4(7), MAP3K5(5), MAP3K7(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MKNK1(2), MKNK2(1), MYEF2(1), NFKB1(2), NR2C2(1), SRF(1), TRAF6(2) 33387178 62 56 62 19 6 11 4 30 10 1 0.541 1.000 1.000 566 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(1), CP(4), CPOX(6), EPRS(5), FECH(2), GUSB(7), HCCS(1), HMOX1(3), HMOX2(1), PPOX(2), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4), UROD(2) 27378863 60 55 54 18 5 5 12 21 17 0 0.684 1.000 1.000 567 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(2), AKT1(3), BAD(1), BAX(1), CSF2RB(5), IGF1R(3), IL3(1), KIT(3), KITLG(2), PIK3CA(14), PIK3R1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3) 21684365 54 53 49 18 8 9 4 25 8 0 0.595 1.000 1.000 568 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(4), F2R(2), F2RL3(1), GNAI1(2), GNB1(3), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), PLA2G4A(2), PLCB1(4), PRKCA(2), PTGS1(2), PTK2(3), RAF1(4), SRC(4), SYK(2), TBXAS1(4) 24358796 58 53 57 18 6 8 9 18 16 1 0.686 1.000 1.000 569 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(2), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), NOS1(10), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), SYT1(1) 25363665 56 51 55 20 10 9 4 24 9 0 0.713 1.000 1.000 570 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(10), EP300(16), NCOA3(8), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RARA(4) 20453810 52 50 49 18 3 4 8 23 14 0 0.773 1.000 1.000 571 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(2), CFL1(1), GNAS(5), GNB1(3), HRAS(1), LIMK1(7), MAPK3(3), MYL2(1), NOX1(7), PIK3C2G(5), PLCB1(4), PPP1R12B(2), PRKCA(2), PTK2(3), RAF1(4), ROCK2(4) 25512537 54 50 49 14 5 7 7 20 15 0 0.673 1.000 1.000 572 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), B4GALT1(1), G6PC(3), GAA(3), GALE(2), GALK1(1), GALK2(2), GALT(3), GCK(2), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(7), MGAM(9), PFKM(3), PFKP(3), PGM1(1) 32229810 55 50 54 24 7 6 6 18 18 0 0.978 1.000 1.000 573 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), CARS(6), DARS(3), EPRS(5), HARS(1), IARS(4), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(4), QARS(1), RARS(3), SARS(3), TARS(6), WARS(1), WARS2(4), YARS(1) 32235504 58 49 53 16 1 6 8 26 17 0 0.685 1.000 1.000 574 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(11), CALM2(1), CAPN2(4), EP300(16), HDAC1(2), MEF2D(1), NFATC1(4), NFATC2(8), PPP3CA(3), PPP3CC(3), PRKCA(2), SYT1(1) 23801443 56 49 51 19 8 4 4 21 19 0 0.884 1.000 1.000 575 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(4), GTF2A1(2), GTF2B(2), GTF2E1(1), GTF2F1(1), NCOA1(4), NCOA2(11), NCOA3(8), NCOR2(7), POLR2A(13), RARA(4), TBP(1) 24972585 58 48 51 29 6 6 8 17 21 0 0.985 1.000 1.000 576 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(1), ARSD(3), ARSE(2), ASAH1(3), GAL3ST1(4), GALC(3), GBA(3), GLA(1), GLB1(5), LCT(7), NEU1(1), PPAP2B(1), PPAP2C(3), SMPD1(6), SMPD2(3), SPTLC1(1), SPTLC2(2) 23445985 51 46 50 18 9 7 4 20 11 0 0.739 1.000 1.000 577 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(2), ASRGL1(4), CA1(1), CA13(2), CA14(3), CA5B(2), CA6(1), CA7(1), CA9(2), CPS1(6), CTH(2), GLS(7), GLS2(4), GLUD2(7), GLUL(2), HAL(1) 21102099 47 46 42 15 2 6 6 25 8 0 0.724 1.000 1.000 578 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(3), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(7), GSK3A(3), GSK3B(3), LYN(1), PFKL(3), PFKM(3), PFKP(3), PLCG1(4), PRKCE(4), PRKCZ(2), RAB5A(1), RAC1(1), RPS6KB1(2), VAV2(4) 25044969 51 46 48 18 3 7 10 18 13 0 0.843 1.000 1.000 579 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(9), ASAH1(3), CAMP(1), CERK(6), CREB3(2), CREB5(3), DAG1(3), EPHB2(2), FOS(1), ITPKA(2), ITPKB(2), JUN(2), MAP2K7(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2) 27735983 48 44 45 16 8 4 8 14 14 0 0.801 1.000 1.000 580 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(9), COL4A6(7), P4HB(2), SLC23A1(7), SLC23A2(2), SLC2A1(2), SLC2A3(2) 25533935 47 44 47 18 4 12 5 17 8 1 0.733 1.000 1.000 581 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(4), ADRB2(2), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), DRD1(1), DRD2(1), DRD3(3), DRD5(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2) 24622013 48 43 46 25 8 4 3 23 10 0 0.971 1.000 1.000 582 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 ATF1(2), CASP2(1), CHUK(2), IKBKB(3), IKBKG(1), JUN(2), LTA(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAP3K14(2), MAP4K2(1), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TANK(1), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 24269862 46 43 43 15 4 6 2 19 14 1 0.906 1.000 1.000 583 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), ARSB(1), ARSD(3), ARSE(2), CYP11B1(3), CYP11B2(2), HSD11B2(1), HSD17B2(1), HSD17B8(1), HSD3B1(1), SRD5A1(1), SULT1E1(2), SULT2A1(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4) 27033091 46 42 46 14 4 3 11 12 16 0 0.535 1.000 1.000 584 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(6), CSK(4), CTNNA1(7), CTNNA2(8), CTNNB1(2), PTK2(3), PXN(3), SRC(4), VCL(2) 19060330 44 42 44 17 8 6 6 17 6 1 0.826 1.000 1.000 585 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(8), DDX20(7), E2F1(1), ETS1(2), ETS2(1), FOS(1), HDAC5(3), HRAS(1), JUN(2), NCOR2(7), RBL2(5), SIN3A(4), SIN3B(3) 26135928 45 42 45 13 7 5 4 17 12 0 0.545 1.000 1.000 586 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 CHUK(2), IKBKB(3), IKBKG(1), IL1R1(3), IRAK1(3), MAP3K1(8), MAP3K14(2), MAP3K7(3), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TLR4(3), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF6(2) 24297343 48 42 45 15 5 11 3 11 16 2 0.706 1.000 1.000 587 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(10), CD2(2), CD33(2), CD5(1), IFNA1(2), IFNB1(3), IL3(1), IL4(1), ITGAX(8), TLR2(2), TLR4(3), TLR7(6), TLR9(1) 18230793 42 40 41 14 5 6 11 14 6 0 0.575 1.000 1.000 588 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA3(3), ANXA4(3), ANXA6(3), CYP11A1(2), EDNRB(3), HPGD(1), HSD11B2(1), PLA2G4A(2), PTGDR(2), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), PTGS1(2), PTGS2(5), TBXAS1(4) 20337800 42 40 42 20 5 4 8 15 9 1 0.953 1.000 1.000 589 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BAG4(1), BIRC2(3), BIRC3(5), CASP8(1), CFLAR(1), IKBKG(1), JUN(2), MAP3K3(2), MAP3K7(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), NR2C2(1), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1) 26674377 42 39 42 15 4 8 7 18 4 1 0.658 1.000 1.000 590 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT6(1), AGPS(5), CHPT1(3), ENPP2(3), ENPP6(1), PAFAH1B1(1), PAFAH1B2(1), PAFAH2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(7), PPAP2B(1), PPAP2C(3) 23345073 42 38 39 18 7 4 5 17 9 0 0.894 1.000 1.000 591 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX5(4), CYP1A2(4), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(3), CYP3A43(2), CYP3A5(1), CYP3A7(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), RDH11(4), RDH13(1) 23945609 39 37 38 16 6 3 4 18 8 0 0.824 1.000 1.000 592 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(7), GALNT2(3), GALNT4(1), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GCNT1(2), ST3GAL1(2), ST3GAL4(2), WBSCR17(6) 14590676 38 36 35 22 3 2 7 12 14 0 0.998 1.000 1.000 593 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(14), PIK3R1(5), PLCB1(4), PLCG1(4), PRKCA(2), VAV1(4) 12929470 36 35 30 11 3 10 4 12 7 0 0.550 1.000 1.000 594 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(2), DPYD(5), DPYS(4), ENPP1(4), ENPP3(2), ILVBL(3), PANK1(2), PANK2(5), PANK3(3), PANK4(1), PPCS(1), UPB1(2), VNN1(1) 17126387 36 34 36 12 3 4 5 14 10 0 0.769 1.000 1.000 595 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(2), CA1(1), CA14(3), CA5B(2), CA6(1), CA7(1), CA9(2), CPS1(6), CTH(2), GLS(7), GLS2(4), GLUL(2), HAL(1) 18914320 34 33 34 11 1 5 4 20 4 0 0.747 1.000 1.000 596 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(4), ILVBL(3), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1), VARS(4), VARS2(6) 17577080 36 32 36 11 2 7 6 12 9 0 0.531 1.000 1.000 597 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), ARHGDIB(1), BIRC2(3), BIRC3(5), CASP1(3), CASP10(4), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), LMNB1(3), LMNB2(1), PRF1(1) 19078382 34 31 34 12 0 8 7 12 7 0 0.765 1.000 1.000 598 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(1), GRM1(5), PLCB1(4), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3) 15890797 31 31 31 12 4 0 0 17 10 0 0.860 1.000 1.000 599 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(1), GLB1(5), HEXA(4), LCT(7), SLC33A1(2), ST3GAL1(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1) 16040691 34 31 34 12 5 6 2 13 8 0 0.671 1.000 1.000 600 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(10), EP300(16), MAPK3(3), PELP1(1), SRC(4) 14702121 34 31 31 15 2 6 6 10 10 0 0.906 1.000 1.000 601 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(7), JAK2(7), JAK3(4), MAPK3(3), STAT3(3), TYK2(7) 11689003 31 31 30 10 2 0 8 12 9 0 0.848 1.000 1.000 602 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(5), KHK(8), LCT(7), MPI(2), PGM1(1), PYGL(2), PYGM(4), TPI1(2) 13537100 31 30 31 11 8 1 6 12 4 0 0.628 1.000 1.000 603 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(2), PSMD11(4), PSMD12(1), PSMD13(2), PSMD2(5), PSMD6(2) 16157887 33 30 32 11 3 3 4 8 15 0 0.833 1.000 1.000 604 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(3), CLOCK(4), CRY1(1), CSNK1E(3), NPAS2(1), PER1(6), PER2(6), PER3(6) 16900305 30 30 28 13 4 2 7 10 6 1 0.904 1.000 1.000 605 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(8), ACACB(5), FASN(9), MCAT(2), OLAH(2), OXSM(3) 15626713 29 29 29 10 3 7 5 10 4 0 0.543 1.000 1.000 606 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(2), B3GAT2(1), B3GAT3(1), CHPF(1), CHST11(1), CHST12(2), CHST14(1), CHST3(2), CHST7(2), CHSY1(9), DSE(1), UST(1), XYLT1(5), XYLT2(2) 12755299 31 29 25 11 5 6 0 9 11 0 0.774 1.000 1.000 607 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1A3(3), ALDH1B1(4), ALDH2(5), ALDH3A2(3), ALDH7A1(1) 13352507 28 28 25 10 2 2 3 14 7 0 0.891 1.000 1.000 608 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(10), EIF4E(2), FBL(1), GPT(4), LDHB(2), LDHC(3), MAPK14(1), NCL(6) 8935488 29 27 28 10 0 1 11 9 8 0 0.859 1.000 1.000 609 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1L(1), BNIP1(1), GOSR1(1), SEC22B(1), SNAP23(1), SNAP29(1), STX10(1), STX11(2), STX16(1), STX17(1), STX18(1), STX19(1), STX2(2), STX4(2), STX5(1), STX7(2), STX8(1), TSNARE1(3), USE1(1), VAMP1(1), VAMP2(1), VTI1A(1) 16806685 28 26 28 11 4 4 4 13 3 0 0.706 1.000 1.000 610 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(4), ITPKA(2), PDE1A(1), PDE1B(5), PLCB1(4), PLCB2(4), TRH(8) 10973760 28 26 21 10 6 2 0 7 13 0 0.929 1.000 1.000 611 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(4), GABRA1(2), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GPHN(6), SRC(4), UBQLN1(3) 12058520 26 25 26 12 2 5 6 10 2 1 0.892 1.000 1.000 612 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(5), ALAS2(5), CPO(1), FECH(2), GATA1(4), HBB(3), UROD(2) 8054820 22 22 20 10 2 2 3 10 5 0 0.912 1.000 1.000 613 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(5), ALAS2(5), CPOX(6), FECH(2), PPOX(2), UROD(2) 7692088 22 22 17 10 1 1 3 7 10 0 0.962 1.000 1.000 614 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCL2(1), CCR5(1), CXCR4(1), FOS(1), JUN(2), MAPK14(1), PLCG1(4), PRKCA(2), PTK2B(3), SYT1(1) 13655108 18 16 17 11 2 4 2 6 4 0 0.984 1.000 1.000 615 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(2) 2083524 5 5 5 3 0 2 1 2 0 0 0.875 1.000 1.000 616 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(2) 1622802 2 2 2 3 0 0 2 0 0 0 0.974 1.000 1.000