Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.167 0.273 0.604 241.0 -9999.0 0.0 241.0 KIRREL -0.078 0.249 -9999.0 0.0 -0.855 82.0 82.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.167 0.274 -9999.0 0.0 -0.605 241.0 241.0 PLCG1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.163 0.247 -9999.0 0.0 -0.58 189.0 189.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.081 0.187 -9999.0 0.0 -0.406 188.0 188.0 FYN -0.136 0.246 -9999.0 0.0 -0.547 193.0 193.0 mol:Ca2+ -0.16 0.243 -9999.0 0.0 -0.573 188.0 188.0 mol:DAG -0.161 0.245 -9999.0 0.0 -0.576 188.0 188.0 NPHS2 -0.093 0.227 -9999.0 0.0 -0.681 113.0 113.0 mol:IP3 -0.161 0.245 -9999.0 0.0 -0.576 188.0 188.0 regulation of endocytosis -0.143 0.218 -9999.0 0.0 -0.512 188.0 188.0 Nephrin/NEPH1/podocin/Cholesterol -0.166 0.251 -9999.0 0.0 -0.59 188.0 188.0 establishment of cell polarity -0.167 0.273 -9999.0 0.0 -0.604 241.0 241.0 Nephrin/NEPH1/podocin/NCK1-2 -0.148 0.227 -9999.0 0.0 -0.555 150.0 150.0 Nephrin/NEPH1/beta Arrestin2 -0.132 0.23 -9999.0 0.0 -0.52 188.0 188.0 NPHS1 -0.135 0.288 -9999.0 0.0 -0.73 166.0 166.0 Nephrin/NEPH1/podocin -0.155 0.236 -9999.0 0.0 -0.55 193.0 193.0 TJP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.014 0.041 -9999.0 0.0 -0.848 2.0 2.0 NCK2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.162 0.246 -9999.0 0.0 -0.58 188.0 188.0 CD2AP 0.015 0.022 -9999.0 0.0 -0.65 1.0 1.0 Nephrin/NEPH1/podocin/GRB2 -0.162 0.246 -9999.0 0.0 -0.58 188.0 188.0 GRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.25 0.326 -9999.0 0.0 -0.62 333.0 333.0 cytoskeleton organization -0.107 0.24 -9999.0 0.0 -0.534 167.0 167.0 Nephrin/NEPH1 -0.125 0.207 -9999.0 0.0 -0.452 241.0 241.0 Nephrin/NEPH1/ZO-1 -0.135 0.225 -9999.0 0.0 -0.528 186.0 186.0