Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.233 0.337 -9999.0 0.0 -0.875 101.0 101.0 IHH -0.169 0.324 -9999.0 0.0 -0.807 176.0 176.0 SHH Np/Cholesterol/GAS1 -0.081 0.189 -9999.0 0.0 -0.583 76.0 76.0 LRPAP1 0.014 0.041 -9999.0 0.0 -0.848 2.0 2.0 dorsoventral neural tube patterning 0.081 0.187 0.577 76.0 -9999.0 0.0 76.0 SMO/beta Arrestin2 -0.146 0.247 -9999.0 0.0 -0.662 95.0 95.0 SMO -0.162 0.26 -9999.0 0.0 -0.637 142.0 142.0 AKT1 -0.053 0.131 -9999.0 0.0 -0.69 8.0 8.0 ARRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.004 0.13 -9999.0 0.0 -0.838 21.0 21.0 ADRBK1 0.014 0.041 -9999.0 0.0 -0.848 2.0 2.0 heart looping -0.159 0.256 -9999.0 0.0 -0.625 142.0 142.0 STIL -0.157 0.254 -9999.0 0.0 -0.663 103.0 103.0 DHH N/PTCH2 -0.068 0.194 -9999.0 0.0 -0.597 101.0 101.0 DHH N/PTCH1 -0.169 0.257 -9999.0 0.0 -0.659 121.0 121.0 PIK3CA 0.01 0.071 -9999.0 0.0 -0.848 6.0 6.0 DHH -0.04 0.202 -9999.0 0.0 -0.766 63.0 63.0 PTHLH -0.399 0.536 -9999.0 0.0 -1.225 215.0 215.0 determination of left/right symmetry -0.159 0.256 -9999.0 0.0 -0.625 142.0 142.0 PIK3R1 0.011 0.066 -9999.0 0.0 -0.782 6.0 6.0 skeletal system development -0.391 0.524 -9999.0 0.0 -1.196 215.0 215.0 IHH N/Hhip -0.209 0.318 -9999.0 0.0 -0.633 292.0 292.0 DHH N/Hhip -0.146 0.261 -9999.0 0.0 -0.572 227.0 227.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.159 0.256 -9999.0 0.0 -0.625 142.0 142.0 pancreas development -0.131 0.292 -9999.0 0.0 -0.705 180.0 180.0 HHAT 0.009 0.076 -9999.0 0.0 -0.848 7.0 7.0 PI3K -0.008 0.072 -9999.0 0.0 -0.623 12.0 12.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.011 0.138 -9999.0 0.0 -0.71 33.0 33.0 somite specification -0.159 0.256 -9999.0 0.0 -0.625 142.0 142.0 SHH Np/Cholesterol/PTCH1 -0.173 0.263 -9999.0 0.0 -0.664 125.0 125.0 SHH Np/Cholesterol/PTCH2 -0.088 0.196 -9999.0 0.0 -0.574 88.0 88.0 SHH Np/Cholesterol/Megalin -0.154 0.282 -9999.0 0.0 -0.65 177.0 177.0 SHH -0.06 0.221 -9999.0 0.0 -0.584 128.0 128.0 catabolic process -0.16 0.246 -9999.0 0.0 -0.593 151.0 151.0 SMO/Vitamin D3 -0.177 0.275 -9999.0 0.0 -0.689 127.0 127.0 SHH Np/Cholesterol/Hhip -0.149 0.251 -9999.0 0.0 -0.636 132.0 132.0 LRP2 -0.132 0.325 -9999.0 0.0 -0.844 153.0 153.0 receptor-mediated endocytosis -0.246 0.291 -9999.0 0.0 -0.761 163.0 163.0 SHH Np/Cholesterol/BOC -0.078 0.185 -9999.0 0.0 -0.477 146.0 146.0 SHH Np/Cholesterol/CDO -0.091 0.201 -9999.0 0.0 -0.574 99.0 99.0 mesenchymal cell differentiation 0.147 0.248 0.63 132.0 -9999.0 0.0 132.0 mol:Vitamin D3 -0.172 0.266 -9999.0 0.0 -0.668 125.0 125.0 IHH N/PTCH2 -0.122 0.257 -9999.0 0.0 -0.567 208.0 208.0 CDON -0.026 0.181 -9999.0 0.0 -0.796 46.0 46.0 IHH N/PTCH1 -0.162 0.249 -9999.0 0.0 -0.602 151.0 151.0 Megalin/LRPAP1 -0.113 0.246 -9999.0 0.0 -0.649 155.0 155.0 PTCH2 -0.021 0.167 -9999.0 0.0 -0.776 41.0 41.0 SHH Np/Cholesterol -0.068 0.171 -9999.0 0.0 -0.47 128.0 128.0 PTCH1 -0.161 0.247 -9999.0 0.0 -0.596 151.0 151.0 HHIP -0.131 0.292 -9999.0 0.0 -0.706 180.0 180.0