Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.007 0.101 -9999.0 0.0 -0.347 53.0 53.0 epithelial cell differentiation -0.037 0.12 -9999.0 0.0 -0.481 44.0 44.0 CYFIP2 0.008 0.078 -9999.0 0.0 -0.76 9.0 9.0 ENAH 0.045 0.12 -9999.0 0.0 -0.511 13.0 13.0 EGFR -0.021 0.169 -9999.0 0.0 -0.785 41.0 41.0 EPHA2 0.006 0.094 -9999.0 0.0 -0.83 11.0 11.0 MYO6 0.008 0.134 -9999.0 0.0 -0.475 45.0 45.0 CTNNB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.05 -9999.0 0.0 -0.491 9.0 9.0 AQP5 -0.057 0.125 -9999.0 0.0 -0.578 14.0 14.0 CTNND1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.008 0.127 -9999.0 0.0 -0.447 46.0 46.0 regulation of calcium-dependent cell-cell adhesion -0.105 0.246 -9999.0 0.0 -0.532 169.0 169.0 EGF -0.148 0.312 -9999.0 0.0 -0.728 196.0 196.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.084 0.21 -9999.0 0.0 -0.694 77.0 77.0 cortical microtubule organization -0.037 0.12 -9999.0 0.0 -0.481 44.0 44.0 GO:0000145 0.009 0.121 -9999.0 0.0 -0.426 46.0 46.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.038 0.122 -9999.0 0.0 -0.487 44.0 44.0 MLLT4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.041 0.129 -9999.0 0.0 -0.735 14.0 14.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.018 0.101 -9999.0 0.0 -0.546 28.0 28.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.02 0.132 -9999.0 0.0 -0.584 7.0 7.0 PVRL2 0.015 0.029 -9999.0 0.0 -0.848 1.0 1.0 ZYX 0.007 0.131 -9999.0 0.0 -0.462 4.0 4.0 ARF6/GTP -0.016 0.092 -9999.0 0.0 -0.5 28.0 28.0 CDH1 -0.054 0.224 -9999.0 0.0 -0.759 80.0 80.0 EGFR/EGFR/EGF/EGF -0.131 0.219 -9999.0 0.0 -0.731 49.0 49.0 RhoA/GDP -0.035 0.112 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.017 0.127 -9999.0 0.0 -0.84 2.0 2.0 IGF-1R heterotetramer 0.013 0.05 -9999.0 0.0 -0.846 3.0 3.0 GIT1 0.014 0.041 -9999.0 0.0 -0.848 2.0 2.0 IGF1R 0.013 0.05 -9999.0 0.0 -0.848 3.0 3.0 IGF1 -0.058 0.224 -9999.0 0.0 -0.724 89.0 89.0 DIAPH1 -0.007 0.068 -9999.0 0.0 -0.891 5.0 5.0 Wnt receptor signaling pathway 0.037 0.12 0.481 44.0 -9999.0 0.0 44.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.041 0.13 -9999.0 0.0 -0.734 14.0 14.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.017 0.13 -9999.0 0.0 -0.881 2.0 2.0 EFNA1 0.001 0.115 -9999.0 0.0 -0.848 16.0 16.0 LPP 0.011 0.144 -9999.0 0.0 -0.782 7.0 7.0 Ephrin A1/EPHA2 -0.047 0.149 -9999.0 0.0 -0.843 14.0 14.0 SEC6/SEC8 -0.031 0.099 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.108 0.252 -9999.0 0.0 -0.544 169.0 169.0 HGF/MET -0.091 0.193 -9999.0 0.0 -0.836 24.0 24.0 HGF -0.094 0.278 -9999.0 0.0 -0.785 122.0 122.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.007 0.101 -9999.0 0.0 -0.35 53.0 53.0 actin cable formation 0.066 0.113 -9999.0 0.0 -0.443 11.0 11.0 KIAA1543 0.007 0.166 -9999.0 0.0 -1.116 8.0 8.0 KIFC3 -0.006 0.163 -9999.0 0.0 -0.503 72.0 72.0 NCK1 0.014 0.041 -9999.0 0.0 -0.848 2.0 2.0 EXOC3 0.015 0.029 -9999.0 0.0 -0.848 1.0 1.0 ACTN1 0.003 0.144 -9999.0 0.0 -0.486 55.0 55.0 NCK1/GIT1 -0.003 0.044 -9999.0 0.0 -0.652 4.0 4.0 mol:GDP -0.037 0.12 -9999.0 0.0 -0.481 44.0 44.0 EXOC4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.009 0.128 -9999.0 0.0 -0.462 1.0 1.0 PIP5K1C 0.008 0.129 -9999.0 0.0 -0.455 46.0 46.0 LIMA1 0.002 0.096 -9999.0 0.0 -0.661 18.0 18.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.036 0.113 -9999.0 0.0 -0.622 15.0 15.0 adherens junction assembly 0.013 0.193 -9999.0 0.0 -0.883 21.0 21.0 IGF-1R heterotetramer/IGF1 -0.07 0.168 -9999.0 0.0 -0.728 22.0 22.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.001 0.022 -9999.0 0.0 -0.652 1.0 1.0 MET 0.009 0.075 -9999.0 0.0 -0.774 8.0 8.0 PLEKHA7 0.002 0.149 -9999.0 0.0 -0.511 51.0 51.0 mol:GTP -0.017 0.1 -9999.0 0.0 -0.541 28.0 28.0 establishment of epithelial cell apical/basal polarity 0.043 0.118 -9999.0 0.0 -0.762 1.0 1.0 cortical actin cytoskeleton stabilization 0.007 0.101 -9999.0 0.0 -0.347 53.0 53.0 regulation of cell-cell adhesion 0.017 0.127 -9999.0 0.0 -0.84 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.007 0.101 -9999.0 0.0 -0.35 53.0 53.0