Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
HIF-1-alpha transcription factor network	196.0	14968.0	76.0	-0.757	0.026	1000.0	-1000.0	-0.133	-1000.0
VEGFR1 specific signals	188.0	10531.0	56.0	-0.4	0.016	1000.0	-1000.0	-0.095	-1000.0
Endothelins	187.0	18031.0	96.0	-0.423	0.016	1000.0	-1000.0	-0.09	-1000.0
FOXA2 and FOXA3 transcription factor networks	178.0	8225.0	46.0	-0.74	0.025	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	158.0	19773.0	125.0	-0.484	0.016	1000.0	-1000.0	-0.131	-1000.0
Syndecan-1-mediated signaling events	142.0	4854.0	34.0	-0.291	0.016	1000.0	-1000.0	-0.078	-1000.0
Syndecan-4-mediated signaling events	140.0	9439.0	67.0	-0.393	0.087	1000.0	-1000.0	-0.12	-1000.0
Angiopoietin receptor Tie2-mediated signaling	131.0	11552.0	88.0	-0.41	0.038	1000.0	-1000.0	-0.135	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	130.0	4431.0	34.0	-0.25	0.016	1000.0	-1000.0	-0.088	-1000.0
Ephrin A  reverse signaling	130.0	910.0	7.0	-0.134	-0.0	1000.0	-1000.0	-0.048	-1000.0
IL4-mediated signaling events	130.0	11856.0	91.0	-0.79	0.544	1000.0	-1000.0	-0.146	-1000.0
IL23-mediated signaling events	129.0	7755.0	60.0	-0.476	0.017	1000.0	-1000.0	-0.163	-1000.0
HIF-2-alpha transcription factor network	128.0	5517.0	43.0	-0.441	0.314	1000.0	-1000.0	-0.112	-1000.0
PDGFR-alpha signaling pathway	125.0	5514.0	44.0	-0.214	0.032	1000.0	-1000.0	-0.091	-1000.0
S1P1 pathway	118.0	4266.0	36.0	-0.322	0.016	1000.0	-1000.0	-0.077	-1000.0
p75(NTR)-mediated signaling	111.0	13898.0	125.0	-0.416	0.016	1000.0	-1000.0	-0.138	-1000.0
Signaling events mediated by the Hedgehog family	108.0	5654.0	52.0	-0.399	0.147	1000.0	-1000.0	-0.104	-1000.0
LPA4-mediated signaling events	105.0	1270.0	12.0	-0.168	0.023	1000.0	-1000.0	-0.033	-1000.0
TCR signaling in naïve CD8+ T cells	98.0	9170.0	93.0	-0.231	0.052	1000.0	-1000.0	-0.11	-1000.0
amb2 Integrin signaling	96.0	7952.0	82.0	-0.278	0.016	1000.0	-1000.0	-0.11	-1000.0
EGFR-dependent Endothelin signaling events	96.0	2021.0	21.0	-0.279	0.016	1000.0	-1000.0	-0.098	-1000.0
IL12-mediated signaling events	95.0	8312.0	87.0	-0.343	0.097	1000.0	-1000.0	-0.138	-1000.0
Glypican 2 network	92.0	370.0	4.0	-0.081	-0.028	1000.0	-1000.0	-0.051	-1000.0
BMP receptor signaling	91.0	7382.0	81.0	-0.405	0.034	1000.0	-1000.0	-0.114	-1000.0
Thromboxane A2 receptor signaling	89.0	9434.0	105.0	-0.15	0.054	1000.0	-1000.0	-0.096	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	88.0	5993.0	68.0	-0.389	0.111	1000.0	-1000.0	-0.144	-1000.0
Integrins in angiogenesis	85.0	7149.0	84.0	-0.321	0.026	1000.0	-1000.0	-0.137	-1000.0
Wnt signaling	85.0	597.0	7.0	-0.114	-0.072	1000.0	-1000.0	-0.042	-1000.0
Glypican 1 network	79.0	3818.0	48.0	-0.293	0.036	1000.0	-1000.0	-0.06	-1000.0
PDGFR-beta signaling pathway	77.0	7472.0	97.0	-0.162	0.016	1000.0	-1000.0	-0.119	-1000.0
Class IB PI3K non-lipid kinase events	74.0	222.0	3.0	-0.045	-1000.0	1000.0	-1000.0	-0.015	-1000.0
IL6-mediated signaling events	70.0	5298.0	75.0	-0.376	0.064	1000.0	-1000.0	-0.109	-1000.0
Reelin signaling pathway	69.0	3877.0	56.0	-0.348	0.016	1000.0	-1000.0	-0.109	-1000.0
Calcium signaling in the CD4+ TCR pathway	68.0	2122.0	31.0	-0.273	0.016	1000.0	-1000.0	-0.114	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	68.0	8248.0	120.0	-0.265	0.183	1000.0	-1000.0	-0.101	-1000.0
Signaling events regulated by Ret tyrosine kinase	63.0	5208.0	82.0	-0.213	0.016	1000.0	-1000.0	-0.112	-1000.0
Arf6 signaling events	62.0	3864.0	62.0	-0.215	0.016	1000.0	-1000.0	-0.082	-1000.0
Effects of Botulinum toxin	59.0	1544.0	26.0	-0.206	0.016	1000.0	-1000.0	-0.082	-1000.0
Signaling mediated by p38-alpha and p38-beta	58.0	2592.0	44.0	-0.229	0.016	1000.0	-1000.0	-0.066	-1000.0
TCGA08_retinoblastoma	58.0	464.0	8.0	-0.041	0.023	1000.0	-1000.0	-0.02	-1000.0
Visual signal transduction: Rods	58.0	3032.0	52.0	-0.171	0.016	1000.0	-1000.0	-0.101	-1000.0
BCR signaling pathway	57.0	5673.0	99.0	-0.19	0.042	1000.0	-1000.0	-0.119	-1000.0
Noncanonical Wnt signaling pathway	55.0	1440.0	26.0	-0.15	0.016	1000.0	-1000.0	-0.115	-1000.0
Fc-epsilon receptor I signaling in mast cells	55.0	5418.0	97.0	-0.198	0.037	1000.0	-1000.0	-0.116	-1000.0
Caspase cascade in apoptosis	54.0	4005.0	74.0	-0.103	0.043	1000.0	-1000.0	-0.073	-1000.0
Glucocorticoid receptor regulatory network	54.0	6189.0	114.0	-0.453	0.125	1000.0	-1000.0	-0.093	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	54.0	2015.0	37.0	-0.216	0.016	1000.0	-1000.0	-0.077	-1000.0
S1P3 pathway	54.0	2299.0	42.0	-0.295	0.018	1000.0	-1000.0	-0.076	-1000.0
a4b1 and a4b7 Integrin signaling	52.0	263.0	5.0	-0.066	0.008	1000.0	-1000.0	-0.048	-1000.0
Ephrin B reverse signaling	52.0	2521.0	48.0	-0.127	0.122	1000.0	-1000.0	-0.096	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	52.0	4071.0	78.0	-0.216	0.069	1000.0	-1000.0	-0.111	-1000.0
E-cadherin signaling events	50.0	251.0	5.0	-0.054	0.016	1000.0	-1000.0	-0.052	-1000.0
FOXM1 transcription factor network	49.0	2545.0	51.0	-0.157	0.154	1000.0	-1000.0	-0.192	-1000.0
Nongenotropic Androgen signaling	48.0	2512.0	52.0	-0.097	0.016	1000.0	-1000.0	-0.081	-1000.0
EPHB forward signaling	47.0	4077.0	85.0	-0.135	0.103	1000.0	-1000.0	-0.12	-1000.0
Plasma membrane estrogen receptor signaling	47.0	4075.0	86.0	-0.138	0.027	1000.0	-1000.0	-0.113	-1000.0
Visual signal transduction: Cones	46.0	1750.0	38.0	-0.125	0.015	1000.0	-1000.0	-0.085	-1000.0
JNK signaling in the CD4+ TCR pathway	46.0	789.0	17.0	-0.116	0.016	1000.0	-1000.0	-0.1	-1000.0
IL27-mediated signaling events	46.0	2361.0	51.0	-0.19	0.064	1000.0	-1000.0	-0.111	-1000.0
Syndecan-2-mediated signaling events	44.0	3063.0	69.0	-0.182	0.042	1000.0	-1000.0	-0.082	-1000.0
LPA receptor mediated events	44.0	4538.0	102.0	-0.147	0.021	1000.0	-1000.0	-0.12	-1000.0
EPO signaling pathway	41.0	2255.0	55.0	-0.21	0.016	1000.0	-1000.0	-0.126	-1000.0
Osteopontin-mediated events	40.0	1524.0	38.0	-0.123	0.016	1000.0	-1000.0	-0.141	-1000.0
Signaling events mediated by PTP1B	40.0	3110.0	76.0	-0.148	0.025	1000.0	-1000.0	-0.102	-1000.0
IL2 signaling events mediated by STAT5	40.0	880.0	22.0	-0.097	0.017	1000.0	-1000.0	-0.052	-1000.0
Canonical Wnt signaling pathway	39.0	1998.0	51.0	-0.164	0.04	1000.0	-1000.0	-0.074	-1000.0
Coregulation of Androgen receptor activity	38.0	2893.0	76.0	-0.29	0.034	1000.0	-1000.0	-0.063	-1000.0
IL2 signaling events mediated by PI3K	38.0	2211.0	58.0	-0.102	0.035	1000.0	-1000.0	-0.102	-1000.0
ErbB4 signaling events	36.0	2484.0	69.0	-0.168	0.088	1000.0	-1000.0	-0.111	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	36.0	1981.0	54.0	-0.268	0.034	1000.0	-1000.0	-0.134	-1000.0
Cellular roles of Anthrax toxin	36.0	1423.0	39.0	-0.105	0.019	1000.0	-1000.0	-0.05	-1000.0
IL1-mediated signaling events	35.0	2175.0	62.0	-0.177	0.077	1000.0	-1000.0	-0.132	-1000.0
Sphingosine 1-phosphate (S1P) pathway	34.0	969.0	28.0	-0.086	0.016	1000.0	-1000.0	-0.079	-1000.0
Paxillin-dependent events mediated by a4b1	33.0	1203.0	36.0	-0.11	0.045	1000.0	-1000.0	-0.092	-1000.0
Ras signaling in the CD4+ TCR pathway	33.0	561.0	17.0	-0.037	0.016	1000.0	-1000.0	-0.057	-1000.0
Aurora B signaling	33.0	2276.0	67.0	-0.169	0.016	1000.0	-1000.0	-0.095	-1000.0
Presenilin action in Notch and Wnt signaling	32.0	1978.0	61.0	-0.113	0.047	1000.0	-1000.0	-0.092	-1000.0
FAS signaling pathway (CD95)	32.0	1506.0	47.0	-0.228	0.017	1000.0	-1000.0	-0.069	-1000.0
Signaling mediated by p38-gamma and p38-delta	32.0	483.0	15.0	-0.031	0.02	1000.0	-1000.0	-0.038	-1000.0
TRAIL signaling pathway	30.0	1487.0	48.0	-0.076	0.028	1000.0	-1000.0	-0.105	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	29.0	2158.0	74.0	-0.148	0.066	1000.0	-1000.0	-0.126	-1000.0
S1P5 pathway	28.0	476.0	17.0	-0.057	0.055	1000.0	-1000.0	-0.071	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	27.0	908.0	33.0	-0.213	0.032	1000.0	-1000.0	-0.085	-1000.0
Regulation of p38-alpha and p38-beta	26.0	1427.0	54.0	-0.136	0.019	1000.0	-1000.0	-0.074	-1000.0
ErbB2/ErbB3 signaling events	24.0	1575.0	65.0	-0.1	0.032	1000.0	-1000.0	-0.087	-1000.0
Regulation of nuclear SMAD2/3 signaling	24.0	3295.0	136.0	-0.319	0.311	1000.0	-1000.0	-0.097	-1000.0
Nectin adhesion pathway	24.0	1535.0	63.0	-0.118	0.055	1000.0	-1000.0	-0.109	-1000.0
Syndecan-3-mediated signaling events	24.0	847.0	35.0	-0.162	0.016	1000.0	-1000.0	-0.09	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	24.0	1106.0	45.0	-0.144	0.042	1000.0	-1000.0	-0.118	-1000.0
Regulation of Androgen receptor activity	24.0	1686.0	70.0	-0.3	0.038	1000.0	-1000.0	-0.089	-1000.0
Signaling events mediated by PRL	23.0	790.0	34.0	-0.103	0.024	1000.0	-1000.0	-0.056	-1000.0
p38 MAPK signaling pathway	23.0	1014.0	44.0	-0.248	0.021	1000.0	-1000.0	-0.084	-1000.0
Insulin-mediated glucose transport	21.0	674.0	32.0	-0.231	0.039	1000.0	-1000.0	-0.081	-1000.0
Ceramide signaling pathway	21.0	1616.0	76.0	-0.148	0.039	1000.0	-1000.0	-0.087	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	21.0	1134.0	52.0	-0.118	0.051	1000.0	-1000.0	-0.089	-1000.0
S1P4 pathway	21.0	542.0	25.0	-0.052	0.02	1000.0	-1000.0	-0.071	-1000.0
BARD1 signaling events	20.0	1173.0	57.0	-0.043	0.055	1000.0	-1000.0	-0.098	-1000.0
Aurora A signaling	20.0	1215.0	60.0	-0.2	0.043	1000.0	-1000.0	-0.084	-1000.0
Class I PI3K signaling events	20.0	1501.0	73.0	-0.103	0.032	1000.0	-1000.0	-0.099	-1000.0
Regulation of Telomerase	20.0	2118.0	102.0	-0.256	0.048	1000.0	-1000.0	-0.134	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	19.0	1617.0	83.0	-0.231	0.064	1000.0	-1000.0	-0.096	-1000.0
IGF1 pathway	19.0	1139.0	57.0	-0.06	0.032	1000.0	-1000.0	-0.121	-1000.0
PLK2 and PLK4 events	18.0	56.0	3.0	-0.008	0.014	1000.0	-1000.0	-0.034	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	18.0	1565.0	85.0	-0.094	0.036	1000.0	-1000.0	-0.1	-1000.0
TCGA08_rtk_signaling	18.0	484.0	26.0	-0.181	0.042	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling in keratinocytes	18.0	774.0	43.0	-0.094	0.035	1000.0	-1000.0	-0.089	-1000.0
IFN-gamma pathway	17.0	1217.0	68.0	-0.247	0.05	1000.0	-1000.0	-0.124	-1000.0
TCGA08_p53	17.0	122.0	7.0	-0.031	0.023	1000.0	-1000.0	-0.023	-1000.0
E-cadherin signaling in the nascent adherens junction	17.0	1330.0	76.0	-0.056	0.047	1000.0	-1000.0	-0.108	-1000.0
FoxO family signaling	16.0	1030.0	64.0	-0.306	0.135	1000.0	-1000.0	-0.073	-1000.0
Hedgehog signaling events mediated by Gli proteins	15.0	1010.0	65.0	-0.125	0.051	1000.0	-1000.0	-0.079	-1000.0
Insulin Pathway	15.0	1159.0	74.0	-0.119	0.042	1000.0	-1000.0	-0.12	-1000.0
Rapid glucocorticoid signaling	15.0	319.0	20.0	-0.031	0.016	1000.0	-1000.0	-0.05	-1000.0
Aurora C signaling	14.0	102.0	7.0	-0.036	0.001	1000.0	-1000.0	-0.06	-1000.0
PLK1 signaling events	14.0	1236.0	85.0	-0.038	0.038	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by HDAC Class III	14.0	571.0	40.0	-0.071	0.028	1000.0	-1000.0	-0.057	-1000.0
ceramide signaling pathway	14.0	734.0	49.0	-0.066	0.037	1000.0	-1000.0	-0.052	-1000.0
Atypical NF-kappaB pathway	14.0	434.0	31.0	-0.08	0.033	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by HDAC Class II	12.0	920.0	75.0	-0.07	0.037	1000.0	-1000.0	-0.082	-1000.0
Retinoic acid receptors-mediated signaling	12.0	721.0	58.0	-0.042	0.047	1000.0	-1000.0	-0.094	-1000.0
Circadian rhythm pathway	11.0	248.0	22.0	-0.05	0.041	1000.0	-1000.0	-0.076	-1000.0
Class I PI3K signaling events mediated by Akt	9.0	612.0	68.0	-0.231	0.06	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by HDAC Class I	9.0	946.0	104.0	-0.07	0.069	1000.0	-1000.0	-0.082	-1000.0
Canonical NF-kappaB pathway	8.0	330.0	39.0	-0.062	0.095	1000.0	-1000.0	-0.105	-1000.0
Arf6 downstream pathway	8.0	374.0	43.0	-0.03	0.03	1000.0	-1000.0	-0.045	-1000.0
Arf6 trafficking events	8.0	621.0	71.0	-0.071	0.054	1000.0	-1000.0	-0.097	-1000.0
Alternative NF-kappaB pathway	7.0	92.0	13.0	-0.021	0.016	1000.0	-1000.0	-0.088	-1000.0
mTOR signaling pathway	6.0	333.0	53.0	-0.014	0.036	1000.0	-1000.0	-0.078	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	66.0	23.0	-0.018	0.058	1000.0	-1000.0	-0.094	-1000.0
Arf1 pathway	2.0	140.0	54.0	-0.016	0.036	1000.0	-1000.0	-0.063	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	12.0	27.0	-0.001	0.037	1000.0	-1000.0	-0.081	-1000.0
Total	6846	404941	7203	-24.7632832424	-993.937553334	131000	-131000	-11.9166662327	-131000