E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.005 0.12 -9999.0 0.0 -0.477 38.0 38.0 KLHL20 0.023 0.073 0.19 18.0 -0.253 11.0 29.0 CYFIP2 0.026 0.05 -9999.0 0.0 -0.447 9.0 9.0 Rac1/GDP 0.022 0.088 0.306 15.0 -0.331 6.0 21.0 ENAH -0.005 0.119 -9999.0 0.0 -0.473 39.0 39.0 AP1M1 0.032 0.02 -9999.0 0.0 -0.55 1.0 1.0 RAP1B 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.022 0.057 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.036 -9999.0 0.0 -0.185 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.041 0.098 -9999.0 0.0 -0.333 40.0 40.0 RAPGEF1 0.003 0.111 0.272 13.0 -0.424 31.0 44.0 CTNND1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.001 0.126 -9999.0 0.0 -0.494 38.0 38.0 CRK -0.006 0.11 -9999.0 0.0 -0.454 32.0 32.0 E-cadherin/gamma catenin/alpha catenin 0.029 0.096 -9999.0 0.0 -0.364 35.0 35.0 alphaE/beta7 Integrin 0.038 0.046 -9999.0 0.0 -0.377 9.0 9.0 IQGAP1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.055 0.022 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.005 0.119 -9999.0 0.0 -0.472 38.0 38.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.001 0.038 -9999.0 0.0 -0.204 2.0 2.0 MLLT4 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.05 0.04 -9999.0 0.0 -0.303 6.0 6.0 PI3K 0.003 0.05 -9999.0 0.0 -0.263 2.0 2.0 ARF6 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.014 0.105 -9999.0 0.0 -0.356 54.0 54.0 TIAM1 0.026 0.053 -9999.0 0.0 -0.521 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.043 0.084 -9999.0 0.0 -0.295 35.0 35.0 AKT1 0.01 0.037 0.138 4.0 -0.192 1.0 5.0 PIK3R1 0.029 0.038 -9999.0 0.0 -0.458 5.0 5.0 CDH1 -0.005 0.13 -9999.0 0.0 -0.445 66.0 66.0 RhoA/GDP 0.039 0.099 0.315 37.0 -0.321 6.0 43.0 actin cytoskeleton organization 0.025 0.064 0.189 40.0 -0.207 6.0 46.0 CDC42/GDP 0.046 0.123 0.375 57.0 -0.295 28.0 85.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.006 0.068 -9999.0 0.0 -0.28 36.0 36.0 ITGB7 0.026 0.056 -9999.0 0.0 -0.55 8.0 8.0 RAC1 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.046 0.09 -9999.0 0.0 -0.313 35.0 35.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.028 0.078 -9999.0 0.0 -0.294 35.0 35.0 mol:GDP 0.031 0.133 0.381 59.0 -0.34 31.0 90.0 CDC42/GTP/IQGAP1 0.042 0.012 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.053 -9999.0 0.0 -0.55 7.0 7.0 p120 catenin/RhoA/GDP 0.035 0.096 0.308 21.0 -0.324 6.0 27.0 RAC1/GTP/IQGAP1 0.039 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.047 0.031 -9999.0 0.0 -0.564 2.0 2.0 RHOA 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.027 0.081 0.229 58.0 -0.203 34.0 92.0 NME1 0.029 0.016 -9999.0 0.0 -0.319 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.006 0.121 -9999.0 0.0 -0.481 38.0 38.0 regulation of cell-cell adhesion 0.012 0.047 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.013 0.031 0.095 12.0 -9999.0 0.0 12.0 Rap1/GTP 0.029 0.07 0.266 7.0 -9999.0 0.0 7.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.105 -9999.0 0.0 -0.337 41.0 41.0 CCND1 0.027 0.089 0.253 48.0 -0.254 34.0 82.0 VAV2 0.008 0.146 0.379 4.0 -0.491 45.0 49.0 RAP1/GDP 0.041 0.093 0.343 27.0 -0.338 2.0 29.0 adherens junction assembly -0.006 0.118 -9999.0 0.0 -0.465 38.0 38.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.031 0.028 -9999.0 0.0 -0.55 2.0 2.0 regulation of heterotypic cell-cell adhesion 0.041 0.099 -9999.0 0.0 -0.322 40.0 40.0 E-cadherin/beta catenin -0.005 0.084 -9999.0 0.0 -0.373 39.0 39.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.006 0.119 -9999.0 0.0 -0.475 37.0 37.0 PIK3CA 0.027 0.048 -9999.0 0.0 -0.55 6.0 6.0 Rac1/GTP -0.028 0.079 -9999.0 0.0 -0.369 21.0 21.0 E-cadherin/beta catenin/alpha catenin 0.031 0.091 -9999.0 0.0 -0.343 35.0 35.0 ITGAE 0.029 0.022 -9999.0 0.0 -0.55 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.002 0.129 -9999.0 0.0 -0.505 38.0 38.0