Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.058 0.17 0.338 213.0 -9999.0 0.0 213.0 KIRREL -0.031 0.157 -9999.0 0.0 -0.557 69.0 69.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.059 0.17 -9999.0 0.0 -0.339 213.0 213.0 PLCG1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.032 0.157 -9999.0 0.0 -0.316 166.0 166.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.03 0.108 -9999.0 0.0 -0.291 92.0 92.0 FYN -0.057 0.132 0.271 7.0 -0.294 173.0 180.0 mol:Ca2+ -0.032 0.152 -9999.0 0.0 -0.313 156.0 156.0 mol:DAG -0.031 0.153 -9999.0 0.0 -0.314 156.0 156.0 NPHS2 -0.036 0.12 -9999.0 0.0 -0.339 109.0 109.0 mol:IP3 -0.031 0.153 -9999.0 0.0 -0.314 156.0 156.0 regulation of endocytosis -0.027 0.134 -9999.0 0.0 -0.277 155.0 155.0 Nephrin/NEPH1/podocin/Cholesterol -0.045 0.149 -9999.0 0.0 -0.315 169.0 169.0 establishment of cell polarity -0.058 0.17 -9999.0 0.0 -0.338 213.0 213.0 Nephrin/NEPH1/podocin/NCK1-2 -0.014 0.153 -9999.0 0.0 -0.292 158.0 158.0 Nephrin/NEPH1/beta Arrestin2 -0.026 0.136 -9999.0 0.0 -0.281 154.0 154.0 NPHS1 -0.059 0.17 -9999.0 0.0 -0.4 162.0 162.0 Nephrin/NEPH1/podocin -0.038 0.143 -9999.0 0.0 -0.296 173.0 173.0 TJP1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.03 0.029 -9999.0 0.0 -0.55 2.0 2.0 NCK2 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.03 0.154 -9999.0 0.0 -0.316 156.0 156.0 CD2AP 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.027 0.15 -9999.0 0.0 -0.315 145.0 145.0 GRB2 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.127 0.184 0.281 5.0 -0.354 301.0 306.0 cytoskeleton organization -0.043 0.124 0.212 5.0 -0.35 84.0 89.0 Nephrin/NEPH1 -0.036 0.122 -9999.0 0.0 -0.261 166.0 166.0 Nephrin/NEPH1/ZO-1 -0.024 0.147 -9999.0 0.0 -0.343 112.0 112.0