Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.168 0.263 -9999.0 0.0 -0.6 194.0 194.0 IHH -0.098 0.204 -9999.0 0.0 -0.495 161.0 161.0 SHH Np/Cholesterol/GAS1 -0.009 0.103 -9999.0 0.0 -0.323 66.0 66.0 LRPAP1 0.031 0.028 -9999.0 0.0 -0.55 2.0 2.0 dorsoventral neural tube patterning 0.009 0.102 0.321 66.0 -9999.0 0.0 66.0 SMO/beta Arrestin2 -0.088 0.18 -9999.0 0.0 -0.483 68.0 68.0 SMO -0.101 0.185 -9999.0 0.0 -0.451 124.0 124.0 AKT1 -0.032 0.132 -9999.0 0.0 -0.577 26.0 26.0 ARRB2 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.019 0.083 -9999.0 0.0 -0.538 19.0 19.0 ADRBK1 0.031 0.028 -9999.0 0.0 -0.55 2.0 2.0 heart looping -0.099 0.182 -9999.0 0.0 -0.444 124.0 124.0 STIL -0.085 0.158 0.263 1.0 -0.4 91.0 92.0 DHH N/PTCH2 0.006 0.116 -9999.0 0.0 -0.326 85.0 85.0 DHH N/PTCH1 -0.104 0.174 -9999.0 0.0 -0.43 101.0 101.0 PIK3CA 0.027 0.048 -9999.0 0.0 -0.55 6.0 6.0 DHH -0.001 0.125 -9999.0 0.0 -0.452 59.0 59.0 PTHLH -0.271 0.408 -9999.0 0.0 -0.971 195.0 195.0 determination of left/right symmetry -0.099 0.182 -9999.0 0.0 -0.444 124.0 124.0 PIK3R1 0.029 0.038 -9999.0 0.0 -0.458 5.0 5.0 skeletal system development -0.267 0.402 -9999.0 0.0 -0.956 195.0 195.0 IHH N/Hhip -0.104 0.181 -9999.0 0.0 -0.35 270.0 270.0 DHH N/Hhip -0.038 0.158 -9999.0 0.0 -0.302 208.0 208.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.099 0.182 -9999.0 0.0 -0.444 124.0 124.0 pancreas development -0.05 0.17 -9999.0 0.0 -0.382 173.0 173.0 HHAT 0.028 0.044 -9999.0 0.0 -0.55 5.0 5.0 PI3K 0.04 0.049 -9999.0 0.0 -0.369 11.0 11.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.017 0.081 -9999.0 0.0 -0.384 32.0 32.0 somite specification -0.099 0.182 -9999.0 0.0 -0.444 124.0 124.0 SHH Np/Cholesterol/PTCH1 -0.095 0.156 -9999.0 0.0 -0.4 105.0 105.0 SHH Np/Cholesterol/PTCH2 -0.012 0.104 -9999.0 0.0 -0.314 73.0 73.0 SHH Np/Cholesterol/Megalin -0.046 0.154 -9999.0 0.0 -0.365 144.0 144.0 SHH -0.021 0.114 -9999.0 0.0 -0.409 58.0 58.0 catabolic process -0.111 0.176 -9999.0 0.0 -0.364 239.0 239.0 SMO/Vitamin D3 -0.098 0.177 -9999.0 0.0 -0.452 105.0 105.0 SHH Np/Cholesterol/Hhip -0.037 0.135 -9999.0 0.0 -0.35 104.0 104.0 LRP2 -0.046 0.197 -9999.0 0.0 -0.544 118.0 118.0 receptor-mediated endocytosis -0.125 0.209 -9999.0 0.0 -0.516 132.0 132.0 SHH Np/Cholesterol/BOC -0.008 0.103 -9999.0 0.0 -0.318 73.0 73.0 SHH Np/Cholesterol/CDO -0.014 0.112 -9999.0 0.0 -0.331 80.0 80.0 mesenchymal cell differentiation 0.037 0.134 0.348 104.0 -9999.0 0.0 104.0 mol:Vitamin D3 -0.086 0.168 0.381 1.0 -0.41 97.0 98.0 IHH N/PTCH2 -0.058 0.149 -9999.0 0.0 -0.342 160.0 160.0 CDON 0.007 0.114 -9999.0 0.0 -0.486 43.0 43.0 IHH N/PTCH1 -0.107 0.182 -9999.0 0.0 -0.367 241.0 241.0 Megalin/LRPAP1 -0.018 0.152 -9999.0 0.0 -0.397 114.0 114.0 PTCH2 0.014 0.092 -9999.0 0.0 -0.442 32.0 32.0 SHH Np/Cholesterol -0.012 0.09 -9999.0 0.0 -0.318 58.0 58.0 PTCH1 -0.112 0.177 -9999.0 0.0 -0.365 239.0 239.0 HHIP -0.05 0.17 -9999.0 0.0 -0.382 173.0 173.0