Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.012 0.063 -9999.0 0.0 -0.247 39.0 39.0 epithelial cell differentiation 0.037 0.081 -9999.0 0.0 -0.292 35.0 35.0 CYFIP2 0.026 0.05 -9999.0 0.0 -0.447 9.0 9.0 ENAH 0.028 0.14 0.496 46.0 -0.342 15.0 61.0 EGFR 0.008 0.102 -9999.0 0.0 -0.473 36.0 36.0 EPHA2 0.027 0.049 -9999.0 0.0 -0.55 6.0 6.0 MYO6 0.027 0.104 0.365 31.0 -0.296 36.0 67.0 CTNNB1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.056 0.04 -9999.0 0.0 -0.344 5.0 5.0 AQP5 0.003 0.076 0.314 2.0 -0.578 2.0 4.0 CTNND1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.026 0.101 0.359 29.0 -0.276 37.0 66.0 regulation of calcium-dependent cell-cell adhesion -0.034 0.14 0.361 10.0 -0.319 123.0 133.0 EGF -0.059 0.187 -9999.0 0.0 -0.411 181.0 181.0 NCKAP1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.02 0.15 0.346 1.0 -0.527 59.0 60.0 cortical microtubule organization 0.037 0.081 -9999.0 0.0 -0.292 35.0 35.0 GO:0000145 0.013 0.097 0.309 38.0 -0.264 37.0 75.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.043 0.084 -9999.0 0.0 -0.295 35.0 35.0 MLLT4 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.013 0.074 -9999.0 0.0 -0.451 13.0 13.0 ARF6 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.06 0.074 -9999.0 0.0 -0.338 22.0 22.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.006 0.077 0.353 4.0 -0.345 6.0 10.0 PVRL2 0.032 0.02 -9999.0 0.0 -0.55 1.0 1.0 ZYX 0.01 0.081 0.347 6.0 -0.281 36.0 42.0 ARF6/GTP 0.066 0.073 -9999.0 0.0 -0.316 21.0 21.0 CDH1 -0.005 0.13 -9999.0 0.0 -0.445 66.0 66.0 EGFR/EGFR/EGF/EGF -0.025 0.135 -9999.0 0.0 -0.31 125.0 125.0 RhoA/GDP 0.04 0.079 -9999.0 0.0 -0.278 35.0 35.0 actin cytoskeleton organization 0.019 0.098 0.352 28.0 -0.288 35.0 63.0 IGF-1R heterotetramer 0.031 0.034 -9999.0 0.0 -0.549 3.0 3.0 GIT1 0.028 0.029 -9999.0 0.0 -0.55 2.0 2.0 IGF1R 0.031 0.034 -9999.0 0.0 -0.55 3.0 3.0 IGF1 -0.008 0.129 -9999.0 0.0 -0.4 80.0 80.0 DIAPH1 0.029 0.145 -9999.0 0.0 -0.643 15.0 15.0 Wnt receptor signaling pathway -0.037 0.081 0.292 35.0 -9999.0 0.0 35.0 RHOA 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.013 0.075 -9999.0 0.0 -0.461 13.0 13.0 CTNNA1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.019 0.099 0.355 28.0 -0.295 35.0 63.0 EFNA1 0.021 0.076 -9999.0 0.0 -0.55 15.0 15.0 LPP 0.005 0.086 0.254 15.0 -0.287 40.0 55.0 Ephrin A1/EPHA2 0.025 0.097 -9999.0 0.0 -0.333 47.0 47.0 SEC6/SEC8 -0.001 0.058 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.034 0.142 0.363 10.0 -0.324 123.0 133.0 HGF/MET 0.002 0.116 -9999.0 0.0 -0.32 76.0 76.0 HGF -0.024 0.156 -9999.0 0.0 -0.46 95.0 95.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.012 0.063 -9999.0 0.0 -0.249 39.0 39.0 actin cable formation 0.057 0.167 0.507 69.0 -0.318 13.0 82.0 KIAA1543 0.011 0.106 0.315 37.0 -0.3 41.0 78.0 KIFC3 0.003 0.094 0.354 2.0 -0.299 58.0 60.0 NCK1 0.03 0.029 -9999.0 0.0 -0.55 2.0 2.0 EXOC3 0.031 0.021 -9999.0 0.0 -0.55 1.0 1.0 ACTN1 0.022 0.104 0.357 26.0 -0.289 42.0 68.0 NCK1/GIT1 0.041 0.032 -9999.0 0.0 -0.403 3.0 3.0 mol:GDP 0.037 0.081 -9999.0 0.0 -0.292 35.0 35.0 EXOC4 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.011 0.079 0.354 3.0 -0.281 36.0 39.0 PIP5K1C 0.026 0.102 0.362 29.0 -0.28 37.0 66.0 LIMA1 0.025 0.05 -9999.0 0.0 -0.334 16.0 16.0 ABI1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.037 0.151 0.507 50.0 -0.401 15.0 65.0 adherens junction assembly 0.019 0.154 0.398 51.0 -0.487 29.0 80.0 IGF-1R heterotetramer/IGF1 0.012 0.106 -9999.0 0.0 -0.305 62.0 62.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.044 0.02 -9999.0 0.0 -0.403 1.0 1.0 MET 0.025 0.045 -9999.0 0.0 -0.55 5.0 5.0 PLEKHA7 0.024 0.11 0.368 28.0 -0.314 41.0 69.0 mol:GTP 0.058 0.073 -9999.0 0.0 -0.336 22.0 22.0 establishment of epithelial cell apical/basal polarity 0.029 0.102 0.394 24.0 -0.488 1.0 25.0 cortical actin cytoskeleton stabilization 0.012 0.063 -9999.0 0.0 -0.247 39.0 39.0 regulation of cell-cell adhesion 0.019 0.098 0.352 28.0 -0.288 35.0 63.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.012 0.063 -9999.0 0.0 -0.249 39.0 39.0