Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.006 0.091 0.208 11.0 -9999.0 0.0 11.0 KIRREL 0.008 0.086 -9999.0 0.0 -0.422 3.0 3.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.006 0.091 -9999.0 0.0 -0.208 11.0 11.0 PLCG1 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.007 0.098 -9999.0 0.0 -0.377 5.0 5.0 Nephrin/NEPH1/podocin/CD2AP 0.04 0.092 -9999.0 0.0 -0.206 6.0 6.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.002 0.081 -9999.0 0.0 -0.221 8.0 8.0 FYN -0.02 0.088 0.27 1.0 -0.184 15.0 16.0 mol:Ca2+ 0.037 0.087 -9999.0 0.0 -0.21 6.0 6.0 mol:DAG 0.038 0.088 -9999.0 0.0 -0.21 6.0 6.0 NPHS2 0.008 0.066 -9999.0 0.0 -0.237 5.0 5.0 mol:IP3 0.038 0.088 -9999.0 0.0 -0.21 6.0 6.0 regulation of endocytosis 0.016 0.092 -9999.0 0.0 -0.188 7.0 7.0 Nephrin/NEPH1/podocin/Cholesterol 0.023 0.084 -9999.0 0.0 -0.202 7.0 7.0 establishment of cell polarity 0.006 0.091 -9999.0 0.0 -0.208 11.0 11.0 Nephrin/NEPH1/podocin/NCK1-2 0.051 0.098 -9999.0 0.0 -0.209 6.0 6.0 Nephrin/NEPH1/beta Arrestin2 0.018 0.094 -9999.0 0.0 -0.189 7.0 7.0 NPHS1 -0.004 0.09 -9999.0 0.0 -0.249 9.0 9.0 Nephrin/NEPH1/podocin 0.006 0.1 -9999.0 0.0 -0.184 15.0 15.0 TJP1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.022 0.068 -9999.0 0.0 -0.415 2.0 2.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.039 0.089 -9999.0 0.0 -0.211 6.0 6.0 CD2AP 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.033 0.096 -9999.0 0.0 -0.217 7.0 7.0 GRB2 0.026 0.049 -9999.0 0.0 -0.415 1.0 1.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.047 0.119 0.272 2.0 -0.237 19.0 21.0 cytoskeleton organization -0.007 0.077 -9999.0 0.0 -0.243 4.0 4.0 Nephrin/NEPH1 0.015 0.064 -9999.0 0.0 -0.174 6.0 6.0 Nephrin/NEPH1/ZO-1 0.033 0.081 -9999.0 0.0 -0.236 4.0 4.0