Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.096 0.191 -9999.0 0.0 -0.531 11.0 11.0 IHH -0.048 0.108 -9999.0 0.0 -0.23 17.0 17.0 SHH Np/Cholesterol/GAS1 0.012 0.061 -9999.0 0.0 -0.27 2.0 2.0 LRPAP1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.012 0.06 0.269 2.0 -9999.0 0.0 2.0 SMO/beta Arrestin2 -0.052 0.123 -9999.0 0.0 -0.395 2.0 2.0 SMO -0.057 0.12 -9999.0 0.0 -0.39 3.0 3.0 AKT1 -0.024 0.147 -9999.0 0.0 -0.612 4.0 4.0 ARRB2 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.004 0.108 -9999.0 0.0 -0.383 6.0 6.0 ADRBK1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.059 0.12 -9999.0 0.0 -0.385 3.0 3.0 STIL -0.03 0.093 -9999.0 0.0 -0.282 2.0 2.0 DHH N/PTCH2 0.042 0.04 -9999.0 0.0 -0.293 1.0 1.0 DHH N/PTCH1 -0.047 0.114 -9999.0 0.0 -0.267 12.0 12.0 PIK3CA 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.028 0.049 -9999.0 0.0 -0.415 1.0 1.0 PTHLH -0.159 0.31 -9999.0 0.0 -0.915 11.0 11.0 determination of left/right symmetry -0.059 0.12 -9999.0 0.0 -0.385 3.0 3.0 PIK3R1 0.015 0.086 -9999.0 0.0 -0.367 4.0 4.0 skeletal system development -0.157 0.306 -9999.0 0.0 -0.903 11.0 11.0 IHH N/Hhip -0.036 0.106 -9999.0 0.0 -0.218 15.0 15.0 DHH N/Hhip 0.012 0.092 -9999.0 0.0 -0.19 13.0 13.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.059 0.12 -9999.0 0.0 -0.385 3.0 3.0 pancreas development -0.012 0.108 -9999.0 0.0 -0.25 14.0 14.0 HHAT 0.02 0.054 -9999.0 0.0 -0.222 4.0 4.0 PI3K 0.034 0.067 -9999.0 0.0 -0.256 4.0 4.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.003 0.1 -9999.0 0.0 -0.295 8.0 8.0 somite specification -0.059 0.12 -9999.0 0.0 -0.385 3.0 3.0 SHH Np/Cholesterol/PTCH1 -0.037 0.087 -9999.0 0.0 -0.235 8.0 8.0 SHH Np/Cholesterol/PTCH2 0.024 0.046 -9999.0 0.0 -0.226 2.0 2.0 SHH Np/Cholesterol/Megalin -0.016 0.103 -9999.0 0.0 -0.236 15.0 15.0 SHH 0.011 0.05 -9999.0 0.0 -0.279 2.0 2.0 catabolic process -0.063 0.123 -9999.0 0.0 -0.309 12.0 12.0 SMO/Vitamin D3 -0.045 0.094 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip 0.005 0.073 -9999.0 0.0 -0.286 3.0 3.0 LRP2 -0.051 0.174 -9999.0 0.0 -0.415 16.0 16.0 receptor-mediated endocytosis -0.07 0.123 -9999.0 0.0 -0.369 4.0 4.0 SHH Np/Cholesterol/BOC 0.012 0.078 -9999.0 0.0 -0.296 4.0 4.0 SHH Np/Cholesterol/CDO 0.015 0.064 -9999.0 0.0 -0.249 4.0 4.0 mesenchymal cell differentiation -0.004 0.072 0.284 3.0 -9999.0 0.0 3.0 mol:Vitamin D3 -0.029 0.094 -9999.0 0.0 -0.266 1.0 1.0 IHH N/PTCH2 -0.004 0.072 -9999.0 0.0 -0.184 2.0 2.0 CDON 0.0 0.117 -9999.0 0.0 -0.388 7.0 7.0 IHH N/PTCH1 -0.058 0.129 -9999.0 0.0 -0.31 12.0 12.0 Megalin/LRPAP1 -0.016 0.133 -9999.0 0.0 -0.293 16.0 16.0 PTCH2 0.027 0.049 -9999.0 0.0 -0.415 1.0 1.0 SHH Np/Cholesterol 0.013 0.039 -9999.0 0.0 -0.318 1.0 1.0 PTCH1 -0.063 0.123 -9999.0 0.0 -0.31 12.0 12.0 HHIP -0.012 0.108 -9999.0 0.0 -0.25 14.0 14.0