Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.004 0.071 -9999.0 0.0 -0.219 6.0 6.0 epithelial cell differentiation 0.033 0.079 -9999.0 0.0 -0.207 5.0 5.0 CYFIP2 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.012 0.161 0.664 4.0 -0.263 1.0 5.0 EGFR -0.029 0.14 -9999.0 0.0 -0.333 14.0 14.0 EPHA2 0.028 0.049 -9999.0 0.0 -0.415 1.0 1.0 MYO6 0.02 0.106 0.348 4.0 -0.236 5.0 9.0 CTNNB1 0.026 0.039 -9999.0 0.0 -0.222 2.0 2.0 ABI1/Sra1/Nap1 0.058 0.031 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.009 0.11 -9999.0 0.0 -0.611 2.0 2.0 CTNND1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.019 0.101 0.345 4.0 -0.196 6.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.108 0.344 1.0 -0.221 15.0 16.0 EGF -0.071 0.151 -9999.0 0.0 -0.267 30.0 30.0 NCKAP1 0.027 0.039 -9999.0 0.0 -0.222 2.0 2.0 AQP3 -0.044 0.158 -9999.0 0.0 -0.526 7.0 7.0 cortical microtubule organization 0.033 0.079 -9999.0 0.0 -0.207 5.0 5.0 GO:0000145 0.007 0.097 0.263 7.0 -0.187 6.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.039 0.082 -9999.0 0.0 -0.208 5.0 5.0 MLLT4 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.028 0.08 -9999.0 0.0 -0.28 4.0 4.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.048 0.099 -9999.0 0.0 -0.252 7.0 7.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.005 0.071 0.183 3.0 -0.204 2.0 5.0 PVRL2 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.003 0.069 0.184 3.0 -0.198 5.0 8.0 ARF6/GTP 0.057 0.097 -9999.0 0.0 -0.234 7.0 7.0 CDH1 -0.017 0.127 -9999.0 0.0 -0.319 12.0 12.0 EGFR/EGFR/EGF/EGF -0.05 0.137 -9999.0 0.0 -0.265 18.0 18.0 RhoA/GDP 0.03 0.085 -9999.0 0.0 -0.198 7.0 7.0 actin cytoskeleton organization 0.003 0.08 0.212 4.0 -0.232 5.0 9.0 IGF-1R heterotetramer 0.029 0.048 -9999.0 0.0 -0.415 1.0 1.0 GIT1 0.027 0.049 -9999.0 0.0 -0.415 1.0 1.0 IGF1R 0.029 0.048 -9999.0 0.0 -0.415 1.0 1.0 IGF1 -0.017 0.124 -9999.0 0.0 -0.297 13.0 13.0 DIAPH1 0.041 0.121 -9999.0 0.0 -0.513 3.0 3.0 Wnt receptor signaling pathway -0.033 0.079 0.207 5.0 -9999.0 0.0 5.0 RHOA 0.021 0.068 -9999.0 0.0 -0.415 2.0 2.0 RhoA/GTP -0.031 0.081 -9999.0 0.0 -0.279 4.0 4.0 CTNNA1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.003 0.082 0.213 4.0 -0.237 5.0 9.0 EFNA1 -0.009 0.13 -9999.0 0.0 -0.415 8.0 8.0 LPP -0.014 0.081 0.178 3.0 -0.235 4.0 7.0 Ephrin A1/EPHA2 0.008 0.103 -9999.0 0.0 -0.226 11.0 11.0 SEC6/SEC8 -0.013 0.07 -9999.0 0.0 -0.359 1.0 1.0 MGAT3 -0.029 0.109 0.347 1.0 -0.224 15.0 16.0 HGF/MET 0.015 0.087 -9999.0 0.0 -0.218 7.0 7.0 HGF 0.007 0.093 -9999.0 0.0 -0.319 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.004 0.071 -9999.0 0.0 -0.221 6.0 6.0 actin cable formation 0.043 0.177 0.599 6.0 -9999.0 0.0 6.0 KIAA1543 0.01 0.095 0.265 7.0 -9999.0 0.0 7.0 KIFC3 0.005 0.084 0.347 1.0 -0.236 5.0 6.0 NCK1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.008 0.105 -9999.0 0.0 -0.415 5.0 5.0 ACTN1 0.004 0.109 0.35 3.0 -0.219 9.0 12.0 NCK1/GIT1 0.043 0.039 -9999.0 0.0 -0.293 1.0 1.0 mol:GDP 0.033 0.079 -9999.0 0.0 -0.207 5.0 5.0 EXOC4 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.003 0.086 0.347 1.0 -0.23 6.0 7.0 PIP5K1C 0.019 0.102 0.348 4.0 -0.199 6.0 10.0 LIMA1 0.016 0.072 -9999.0 0.0 -0.261 5.0 5.0 ABI1 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.019 0.174 0.614 5.0 -0.306 1.0 6.0 adherens junction assembly 0.022 0.126 0.404 5.0 -0.377 2.0 7.0 IGF-1R heterotetramer/IGF1 0.002 0.106 -9999.0 0.0 -0.232 10.0 10.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.048 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.022 0.099 0.348 4.0 -0.198 5.0 9.0 mol:GTP 0.046 0.098 -9999.0 0.0 -0.25 7.0 7.0 establishment of epithelial cell apical/basal polarity 0.006 0.117 0.348 3.0 -0.416 2.0 5.0 cortical actin cytoskeleton stabilization 0.004 0.071 -9999.0 0.0 -0.219 6.0 6.0 regulation of cell-cell adhesion 0.003 0.08 0.212 4.0 -0.232 5.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.004 0.071 -9999.0 0.0 -0.221 6.0 6.0