Clinical Features MRNA_CNMF MRNA_CHIERARCHICAL CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q SETD2 46 (10%) 395 0.81623 1 0.13403 0.71 0.53662 1 8.9999e-05 0.0036 0.69902 1 0.2044 0.809 0.36991 1 0.03061 0.32 0.31624 1 0.30133 0.977 0.39197 1 0.21505 0.823 BAP1 44 (10%) 397 0.0041 0.0624 0.00034 0.0102 0.02967 0.32 5e-05 0.003 0.00226 0.0387 0.03044 0.32 9.9999e-06 9e-04 9.9999e-06 9e-04 9.9999e-06 9e-04 3e-05 0.00216 0.16142 0.749 0.69604 1 PBRM1 139 (32%) 302 0.11883 0.684 0.077959 0.53 0.00416 0.0624 9.9999e-06 9e-04 0.00025 0.009 1 1 0.00038 0.0105 0.00054999 0.0132 0.00062999 0.0142 0.0070599 0.102 6.9999e-05 0.00315 0.049 0.412 KDM5C 27 (6%) 414 NA NA NA NA 0.16577 0.749 0.064939 0.497 0.3756 1 0.17336 0.749 0.04801 0.412 0.00115 0.0218 0.01997 0.256 0.03268 0.327 1 1 1 1 VHL 171 (39%) 270 0.0077099 0.107 0.03113 0.32 0.35541 1 0.55463 1 0.04143 0.382 0.33104 1 0.00042 0.0108 0.01321 0.176 0.03588 0.349 0.070509 0.501 0.43148 1 0.63474 1 PTEN 17 (4%) 424 0.30028 0.977 0.11086 0.676 0.18533 0.758 0.17567 0.749 0.24374 0.9 0.27157 0.949 5.9999e-05 0.00309 0.00204 0.0367 0.00406 0.0624 0.17121 0.749 0.052729 0.431 1 1 MTOR 28 (6%) 413 NA NA NA NA 0.5612 1 0.13412 0.71 0.00099999 0.0204 0.00033 0.0102 0.93587 1 0.84118 1 0.36206 1 0.41171 1 0.942 1 1 1 TP53 12 (3%) 429 NA NA NA NA 0.24995 0.9 0.82749 1 0.34861 1 0.14929 0.736 0.13759 0.717 0.04924 0.412 0.16418 0.749 0.37259 1 1 1 1 1 FAM200A 5 (1%) 436 NA NA NA NA 0.72692 1 NA NA 0.00102 0.0204 0.25451 0.907 0.17684 0.749 0.50633 1 0.14181 0.719 0.37796 1 NA NA NA NA NEFH 5 (1%) 436 NA NA NA NA 0.86226 1 0.45441 1 0.97888 1 0.18091 0.757 0.03913 0.371 0.02672 0.31 0.46063 1 0.91316 1 0.33767 1 0.13943 0.717 PTCH1 7 (2%) 434 NA NA NA NA 1 1 0.02063 0.256 0.40113 1 0.15786 0.749 0.88508 1 0.12248 0.684 1 1 0.68351 1 NA NA NA NA NF2 6 (1%) 435 NA NA NA NA 0.02133 0.256 0.34703 1 0.21639 0.823 0.57345 1 0.12 0.684 0.19741 0.797 0.082059 0.547 0.37661 1 NA NA NA NA CCDC120 4 (1%) 437 NA NA NA NA 0.12356 0.684 NA NA 0.42219 1 1 1 0.68563 1 0.84528 1 0.82929 1 1 1 NA NA NA NA PIK3CA 12 (3%) 429 NA NA NA NA 0.42227 1 0.44897 1 0.80432 1 0.33746 1 0.23962 0.899 0.67447 1 0.87191 1 0.8756 1 NA NA NA NA ATM 12 (3%) 429 NA NA NA NA 0.93312 1 0.47112 1 0.59422 1 1 1 0.16438 0.749 0.35075 1 0.10099 0.648 0.072299 0.501 NA NA NA NA KIAA1751 6 (1%) 435 NA NA NA NA 0.57751 1 0.45597 1 0.61782 1 0.094129 0.616 0.43295 1 0.66479 1 0.39088 1 0.35742 1 NA NA NA NA GUSB 4 (1%) 437 NA NA NA NA 0.48028 1 NA NA 0.30964 0.995 0.62227 1 0.19922 0.797 0.30104 0.977 0.55424 1 0.8752 1 NA NA NA NA ARID1A 11 (2%) 430 NA NA NA NA 0.92591 1 0.37763 1 0.97009 1 1 1 0.67617 1 0.96884 1 0.5453 1 0.11811 0.684 0.48151 1 0.29769 0.977 GPR50 3 (1%) 438 NA NA NA NA 0.10256 0.648 0.24969 0.9 0.069059 0.501 0.79216 1 0.80328 1 0.21709 0.823 0.11774 0.684 0.43626 1 NA NA NA NA PCK1 5 (1%) 436 NA NA NA NA 0.38747 1 0.61839 1 1 1 0.81544 1 0.73706 1 0.74357 1 0.73227 1 0.40362 1 NA NA NA NA DPCR1 6 (1%) 435 NA NA NA NA 0.28774 0.977 0.58151 1 0.21236 0.823 1 1 0.17609 0.749 0.04436 0.399 0.76621 1 1 1 NA NA NA NA NFAT5 6 (1%) 435 NA NA NA NA 0.49336 1 0.87807 1 0.24614 0.9 0.52864 1 0.26488 0.935 0.40587 1 0.33529 1 0.071749 0.501 NA NA NA NA EGFR 7 (2%) 434 NA NA NA NA 0.71022 1 0.6806 1 0.74738 1 0.49088 1 0.47769 1 0.94233 1 1 1 0.071439 0.501 NA NA NA NA TRIM6 5 (1%) 436 NA NA NA NA 1 1 1 1 0.74612 1 0.058739 0.469 1 1 0.17285 0.749 0.37487 1 0.55595 1 NA NA NA NA RBMX 4 (1%) 437 NA NA NA NA 0.69217 1 0.61844 1 0.10942 0.676 0.46213 1 0.42761 1 0.47991 1 0.34211 1 0.1641 0.749 NA NA NA NA GPR172B 4 (1%) 437 NA NA NA NA 1 1 NA NA 0.13229 0.71 0.7919 1 0.53822 1 1 1 0.61399 1 1 1 NA NA NA NA FGFR3 4 (1%) 437 NA NA NA NA 0.6942 1 0.8358 1 1 1 1 1 1 1 0.47948 1 0.83239 1 0.28707 0.977 NA NA NA NA ARAP3 3 (1%) 438 NA NA NA NA 0.61799 1 NA NA 1 1 1 1 0.60722 1 1 1 0.79236 1 0.83321 1 NA NA NA NA OPTC 4 (1%) 437 NA NA NA NA 0.58452 1 0.18495 0.758 NA NA NA NA 1 1 0.14398 0.72 0.83168 1 0.29007 0.977 NA NA NA NA GOLGA5 5 (1%) 436 NA NA NA NA 0.059989 0.469 NA NA 0.29742 0.977 0.73049 1 0.52777 1 0.6013 1 1 1 0.51674 1 NA NA NA NA