E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.021 0.124 -9999.0 0.0 -0.478 17.0 17.0 KLHL20 0.022 0.075 0.194 4.0 -0.32 2.0 6.0 CYFIP2 0.014 0.077 -9999.0 0.0 -0.635 7.0 7.0 Rac1/GDP 0.024 0.087 0.304 4.0 -9999.0 0.0 4.0 ENAH -0.02 0.123 -9999.0 0.0 -0.48 18.0 18.0 AP1M1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.028 0.053 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.034 -9999.0 0.0 -0.202 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.038 0.082 -9999.0 0.0 -0.364 17.0 17.0 RAPGEF1 -0.011 0.121 -9999.0 0.0 -0.429 12.0 12.0 CTNND1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.129 -9999.0 0.0 -0.495 18.0 18.0 CRK -0.01 0.12 -9999.0 0.0 -0.444 16.0 16.0 E-cadherin/gamma catenin/alpha catenin 0.028 0.089 -9999.0 0.0 -0.425 16.0 16.0 alphaE/beta7 Integrin 0.042 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.05 0.02 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.017 0.12 -9999.0 0.0 -0.479 16.0 16.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.005 0.029 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.05 0.025 -9999.0 0.0 -0.336 1.0 1.0 PI3K -0.007 0.038 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.022 0.102 -9999.0 0.0 -0.492 19.0 19.0 TIAM1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.031 0.073 -9999.0 0.0 -0.343 14.0 14.0 AKT1 0.021 0.032 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.026 0.03 -9999.0 0.0 -0.635 1.0 1.0 CDH1 0.007 0.119 -9999.0 0.0 -0.618 18.0 18.0 RhoA/GDP 0.041 0.085 0.341 9.0 -9999.0 0.0 9.0 actin cytoskeleton organization 0.023 0.062 0.174 15.0 -0.226 2.0 17.0 CDC42/GDP 0.032 0.107 0.398 12.0 -0.35 1.0 13.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.063 -9999.0 0.0 -0.303 16.0 16.0 ITGB7 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.034 0.078 -9999.0 0.0 -0.364 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.021 0.068 -9999.0 0.0 -0.345 14.0 14.0 mol:GDP 0.021 0.115 0.439 10.0 -0.4 3.0 13.0 CDC42/GTP/IQGAP1 0.039 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.05 -9999.0 0.0 -0.635 3.0 3.0 p120 catenin/RhoA/GDP 0.019 0.081 0.308 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.013 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.02 0.062 0.184 11.0 -0.218 18.0 29.0 NME1 0.028 0.027 -9999.0 0.0 -0.59 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.021 0.124 -9999.0 0.0 -0.484 17.0 17.0 regulation of cell-cell adhesion 0.014 0.042 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.015 0.03 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.034 0.066 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.087 -9999.0 0.0 -0.661 1.0 1.0 CCND1 0.021 0.073 0.204 8.0 -0.273 18.0 26.0 VAV2 -0.016 0.158 -9999.0 0.0 -0.565 15.0 15.0 RAP1/GDP 0.043 0.077 0.291 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.02 0.121 -9999.0 0.0 -0.468 17.0 17.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.047 0.091 -9999.0 0.0 -0.637 1.0 1.0 E-cadherin/beta catenin -0.0 0.078 -9999.0 0.0 -0.407 18.0 18.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.021 0.123 -9999.0 0.0 -0.475 17.0 17.0 PIK3CA 0.027 0.03 -9999.0 0.0 -0.635 1.0 1.0 Rac1/GTP -0.031 0.078 -9999.0 0.0 -0.401 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.023 0.079 -9999.0 0.0 -0.4 14.0 14.0 ITGAE 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.132 -9999.0 0.0 -0.507 18.0 18.0