Clinical Features Time to Death YEARS_TO_BIRTH GENDER KARNOFSKY_PERFORMANCE_SCORE HISTOLOGICAL_TYPE RADIATIONS_RADIATION_REGIMENINDICATION RACE ETHNICITY nMutated (%) nWild-Type logrank test_P logrank test_Q Wilcoxon-test_P Wilcoxon-test_Q Fisher's exact test_P Fisher's exact test_Q Wilcoxon-test_P Wilcoxon-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q IDH1 367 (78%) 106 6.5725e-14 7.52e-11 4.236e-07 6.92e-05 0.73972 1 0.014615 0.47 0.0065499 0.268 0.67851 1 0.083079 0.826 0.56745 1 TP53 226 (48%) 247 0.030027 0.621 1.7428e-11 6.65e-09 0.22782 0.923 0.18814 0.833 9.9999e-06 0.00104 0.0053561 0.245 0.053229 0.771 0.6328 1 ATRX 181 (38%) 292 0.14706 0.831 1.635e-11 6.65e-09 0.70344 1 0.58758 1 9.9999e-06 0.00104 0.011979 0.428 0.42845 1 0.62853 1 CIC 100 (21%) 373 0.004335 0.219 0.043154 0.756 0.4966 1 0.457 1 9.9999e-06 0.00104 0.08688 0.826 0.82174 1 0.77515 1 NOTCH1 42 (9%) 431 0.23148 0.923 0.043608 0.756 0.62745 1 0.48826 1 3e-05 0.00245 1 1 0.43136 1 0.67485 1 EGFR 30 (6%) 443 6.3032e-09 1.44e-06 4.5629e-09 1.3e-06 0.84961 1 0.024237 0.579 0.02481 0.579 0.23502 0.923 0.36816 1 0.62173 1 PIK3R1 20 (4%) 453 0.13972 0.831 0.10037 0.831 0.25289 0.945 0.68386 1 0.47892 1 0.084178 0.826 0.11935 0.831 1 1 IDH2 19 (4%) 454 0.10424 0.831 0.12013 0.831 0.81544 1 0.88102 1 0.00128 0.0861 0.77288 1 0.64476 1 0.16536 0.832 NF1 31 (7%) 442 2.1708e-05 0.00207 0.018882 0.54 0.58099 1 0.4347 1 0.0039 0.215 0.096027 0.826 0.27596 0.971 0.35338 1 PTEN 23 (5%) 450 2.5664e-05 0.00226 0.0044108 0.219 0.39904 1 0.50926 1 0.00126 0.0861 0.41891 1 0.25408 0.945 1 1 FUBP1 46 (10%) 427 0.26157 0.947 0.0049262 0.235 0.53531 1 0.26847 0.966 9.9999e-06 0.00104 1 1 0.73472 1 0.23963 0.929 ARID1A 19 (4%) 454 0.036428 0.686 0.69539 1 0.34812 1 0.52558 1 0.34693 1 0.77288 1 1 1 0.55716 1 PIK3CA 42 (9%) 431 0.56325 1 0.045879 0.771 1 1 0.11612 0.831 0.01635 0.48 0.83808 1 0.83877 1 1 1 STK19 10 (2%) 463 0.42608 1 0.3118 1 0.1126 0.831 0.17634 0.832 0.067389 0.826 0.695 1 1 1 0.059072 0.795 NIPBL 17 (4%) 456 0.0059931 0.254 0.20135 0.853 0.31999 1 0.41475 1 0.074349 0.826 0.54543 1 0.079939 0.826 0.15058 0.831 CREBZF 6 (1%) 467 0.65909 1 0.11575 0.831 0.41149 1 0.11155 0.831 0.11344 0.831 1 1 0.27328 0.971 1 1 TCF12 15 (3%) 458 0.87993 1 0.23208 0.923 0.59832 1 0.77264 1 0.9454 1 0.32264 1 1 1 1 1 TRERF1 6 (1%) 467 0.69687 1 0.28545 0.989 0.090854 0.826 0.62708 1 0.14735 0.831 1 1 1 1 1 1 SRPX 3 (1%) 470 0.23237 0.923 0.099778 0.831 0.083132 0.826 NA NA 0.7869 1 0.47818 1 1 1 1 1 SMARCA4 24 (5%) 449 0.023417 0.579 0.38658 1 0.39881 1 0.11735 0.831 0.93192 1 0.10715 0.831 0.13143 0.831 0.57619 1 EMG1 7 (1%) 466 0.46667 1 0.065107 0.82 0.70441 1 0.46182 1 0.56137 1 1 1 1 1 1 1 FAM47C 18 (4%) 455 0.17664 0.832 0.57096 1 0.33907 1 0.87725 1 0.62268 1 0.76224 1 1 1 0.51667 1 TNRC18 10 (2%) 463 0.74974 1 0.64845 1 0.1975 0.843 0.8116 1 0.065479 0.82 0.695 1 1 1 1 1 DNMT3A 10 (2%) 463 0.062897 0.82 0.48632 1 1 1 0.80386 1 0.30365 1 0.695 1 0.41611 1 0.34565 1 HTRA2 5 (1%) 468 0.34815 1 0.027979 0.621 1 1 NA NA 0.37775 1 0.58837 1 1 1 0.19007 0.833 ZNF709 4 (1%) 469 0.063816 0.82 0.5972 1 0.13511 0.831 NA NA 0.3021 1 0.024591 0.579 0.1931 0.833 0.15502 0.831 RBPJ 7 (1%) 466 0.93585 1 0.055934 0.79 1 1 0.29041 0.995 0.3056 1 1 1 1 1 1 1 NRAS 4 (1%) 469 0.28901 0.993 0.89188 1 1 1 0.50514 1 0.04244 0.756 0.58032 1 1 1 1 1 ZNF292 13 (3%) 460 0.61431 1 0.003946 0.215 0.25788 0.947 0.61176 1 1 1 0.72402 1 0.15682 0.831 1 1 PTPN11 7 (1%) 466 0.20811 0.869 0.34237 1 1 1 0.42801 1 0.27203 0.971 0.62624 1 0.31333 1 1 1 GAGE2D 5 (1%) 468 0.64823 1 0.54955 1 0.3918 1 NA NA 1 1 1 1 0.23723 0.923 0.19007 0.833 ARID2 11 (2%) 462 0.40677 1 0.11369 0.831 1 1 0.94194 1 0.18651 0.833 0.45415 1 0.23617 0.923 1 1 ZMIZ1 8 (2%) 465 0.047244 0.771 0.90425 1 0.30603 1 0.86846 1 0.82477 1 1 1 0.14464 0.831 0.029673 0.621 PDGFRA 8 (2%) 465 0.11767 0.831 0.6997 1 0.7341 1 0.11872 0.831 0.14077 0.831 0.049865 0.771 1 1 0.28715 0.989 ZNF512B 4 (1%) 469 0.1523 0.831 0.5921 1 1 1 NA NA 0.68141 1 0.17174 0.832 1 1 1 1 PPL 5 (1%) 468 0.07458 0.826 0.82388 1 0.65765 1 0.9654 1 0.45307 1 1 1 1 1 1 1 PRX 10 (2%) 463 0.92402 1 0.46816 1 0.34506 1 0.75494 1 0.71752 1 0.695 1 1 1 0.34565 1 NKD2 4 (1%) 469 0.55217 1 0.69221 1 1 1 NA NA 0.37595 1 1 1 1 1 1 1 IRS4 7 (1%) 466 0.22476 0.915 0.49385 1 1 1 0.55162 1 0.11298 0.831 0.62624 1 1 1 0.25608 0.945 SPTAN1 5 (1%) 468 0.086667 0.826 0.4522 1 1 1 0.70411 1 0.22387 0.915 0.25102 0.945 1 1 0.19007 0.833 CIB1 4 (1%) 469 0.42034 1 0.99559 1 1 1 0.86846 1 0.83855 1 1 1 1 1 1 1 EIF1AX 4 (1%) 469 0.34582 1 0.92958 1 0.13511 0.831 0.94028 1 0.19291 0.833 0.17174 0.832 1 1 1 1 SCN4A 6 (1%) 467 0.28273 0.988 0.26106 0.947 0.41149 1 0.25456 0.945 1 1 0.090943 0.826 1 1 1 1 PLCG1 6 (1%) 467 5.9818e-08 1.14e-05 0.015348 0.47 0.41149 1 0.64157 1 0.34705 1 0.33106 1 0.2758 0.971 1 1 DLC1 5 (1%) 468 0.88189 1 0.9829 1 0.65765 1 NA NA 0.54926 1 0.05283 0.771 1 1 1 1 TMEM216 3 (1%) 470 0.7799 1 0.83181 1 0.083132 0.826 NA NA 0.47392 1 1 1 1 1 1 1 MYT1 6 (1%) 467 0.37203 1 0.40307 1 1 1 0.87494 1 0.14667 0.831 0.33106 1 1 1 1 1 SMARCB1 4 (1%) 469 0.43165 1 0.80655 1 0.63508 1 0.86846 1 0.8391 1 0.024591 0.579 1 1 1 1 RIPK4 8 (2%) 465 0.84461 1 0.32548 1 0.7341 1 0.95907 1 0.75421 1 0.65626 1 0.072839 0.826 1 1 NEU2 4 (1%) 469 0.72042 1 0.13829 0.831 0.63508 1 NA NA 0.67974 1 0.58032 1 1 1 1 1 PTPRH 8 (2%) 465 0.88255 1 0.058665 0.795 0.7341 1 0.21298 0.88 0.43062 1 0.18963 0.833 1 1 1 1 MAPK15 4 (1%) 469 0.0056971 0.251 0.48875 1 0.63508 1 NA NA 0.45886 1 0.58032 1 1 1 1 1 TPX2 3 (1%) 470 0.1405 0.831 0.41113 1 1 1 NA NA 0.629 1 0.098168 0.826 1 1 1 1 SLC12A7 5 (1%) 468 0.096667 0.826 0.56952 1 0.65765 1 0.5809 1 0.64733 1 0.05283 0.771 0.23489 0.923 1 1 PLXNA3 8 (2%) 465 0.13004 0.831 0.29495 1 0.14622 0.831 0.67221 1 1 1 0.049865 0.771 0.04858 0.771 1 1 RET 6 (1%) 467 0.92141 1 0.75973 1 0.41149 1 0.4194 1 0.03704 0.686 1 1 1 1 1 1 ZNF148 4 (1%) 469 0.13995 0.831 0.66124 1 1 1 NA NA 0.45512 1 0.58032 1 0.081839 0.826 1 1 HDAC2 4 (1%) 469 0.5183 1 0.19873 0.845 1 1 NA NA 0.45631 1 0.024591 0.579 1 1 1 1 RBBP6 6 (1%) 467 0.27342 0.971 0.32374 1 1 1 NA NA 1 1 1 1 0.12523 0.831 1 1 MED9 3 (1%) 470 0.19603 0.84 0.86008 1 0.2601 0.947 NA NA 0.01518 0.47 1 1 1 1 1 1 DDX5 5 (1%) 468 0.15633 0.831 0.85222 1 1 1 0.26275 0.948 0.64656 1 0.25102 0.945 1 1 0.15502 0.831 ZC3H11A 5 (1%) 468 0.13136 0.831 0.16162 0.832 0.3918 1 0.17874 0.833 0.15481 0.831 1 1 1 1 1 1 SLC6A3 9 (2%) 464 0.85636 1 0.38294 1 0.51365 1 NA NA 0.75923 1 0.68897 1 1 1 0.25608 0.945 TPTE2 5 (1%) 468 0.41233 1 0.54297 1 0.65765 1 0.17654 0.832 0.050919 0.771 0.58837 1 1 1 1 1 C4BPA 4 (1%) 469 0.49355 1 0.71681 1 0.32331 1 0.6502 1 0.14164 0.831 0.58032 1 1 1 1 1 MATK 5 (1%) 468 0.43126 1 0.44627 1 0.3918 1 NA NA 1 1 0.05283 0.771 1 1 1 1 SMOC1 3 (1%) 470 0.50609 1 0.44707 1 1 1 0.94028 1 0.36208 1 0.098168 0.826 1 1 1 1 NAP1L2 4 (1%) 469 0.28452 0.989 0.18131 0.833 1 1 NA NA 0.30043 1 0.58032 1 1 1 1 1 CD99L2 3 (1%) 470 0.16797 0.832 0.30801 1 0.083132 0.826 NA NA 0.7868 1 0.47818 1 1 1 1 1 SELE 6 (1%) 467 0.82424 1 0.16758 0.832 0.41149 1 0.48305 1 1 1 0.33106 1 1 1 1 1 TMEM184A 3 (1%) 470 0.00041275 0.0315 0.15353 0.831 1 1 NA NA 1 1 0.47818 1 0.14687 0.831 1 1 FHOD1 6 (1%) 467 0.24523 0.945 0.17513 0.832 1 1 NA NA 1 1 1 1 1 1 1 1 HTR3A 7 (1%) 466 0.58094 1 0.54544 1 0.046956 0.771 NA NA 1 1 1 1 0.0078999 0.292 1 1 RB1 5 (1%) 468 0.96753 1 0.38857 1 0.17326 0.832 NA NA 0.22225 0.915 0.05283 0.771 0.23455 0.923 1 1 FGD6 4 (1%) 469 0.77128 1 0.96035 1 0.036083 0.686 0.42801 1 0.56451 1 0.024591 0.579 1 1 1 1 CD72 3 (1%) 470 0.48286 1 0.96781 1 0.58371 1 0.42801 1 0.065919 0.82 1 1 1 1 1 1 NKPD1 3 (1%) 470 0.15803 0.831 0.082342 0.826 0.58371 1 NA NA 0.62814 1 1 1 1 1 0.11855 0.831 MTMR1 4 (1%) 469 0.47184 1 0.17131 0.832 0.32331 1 NA NA 0.68135 1 0.58032 1 1 1 1 1 GPR133 3 (1%) 470 0.12813 0.831 NA NA 0.58371 1 NA NA 1 1 0.47818 1 1 1 0.11855 0.831 CNOT4 5 (1%) 468 0.13143 0.831 0.66579 1 1 1 0.11872 0.831 0.64838 1 1 1 1 1 1 1 ZBTB20 19 (4%) 454 0.20278 0.856 0.5302 1 0.64009 1 0.93759 1 0.17641 0.832 0.55197 1 0.193 0.833 0.53733 1 ROBO3 4 (1%) 469 0.64613 1 0.80797 1 0.32331 1 0.14674 0.831 0.68149 1 0.58032 1 1 1 1 1 PDE8A 6 (1%) 467 0.61965 1 0.030393 0.621 1 1 NA NA 0.45491 1 0.33106 1 1 1 1 1 EEF1D 3 (1%) 470 0.36025 1 0.1011 0.831 0.58371 1 NA NA 1 1 0.0071655 0.283 1 1 1 1 MET 7 (1%) 466 0.25882 0.947 0.44583 1 1 1 0.55391 1 0.56219 1 0.13722 0.831 1 1 1 1 CUL4B 10 (2%) 463 0.34124 1 0.81467 1 0.1126 0.831 0.81692 1 0.30366 1 1 1 0.21171 0.88 1 1 SNX31 4 (1%) 469 0.093939 0.826 0.4648 1 0.32331 1 NA NA 0.83903 1 0.58032 1 1 1 1 1 PHF3 8 (2%) 465 0.90274 1 0.61652 1 0.7341 1 0.21298 0.88 0.53907 1 0.18963 0.833 0.34969 1 0.25608 0.945 G6PC 5 (1%) 468 0.86792 1 0.11201 0.831 0.3918 1 NA NA 0.37699 1 0.25102 0.945 1 1 0.19007 0.833 FOXQ1 3 (1%) 470 0.5001 1 0.25233 0.945 0.58371 1 NA NA 1 1 0.098168 0.826 1 1 1 1 AEBP1 4 (1%) 469 0.42904 1 0.31653 1 1 1 NA NA 0.4575 1 1 1 1 1 1 1 SETD2 8 (2%) 465 0.82562 1 0.031382 0.63 0.7341 1 0.5648 1 0.75185 1 0.18963 0.833 0.34881 1 1 1 DST 11 (2%) 462 0.077456 0.826 0.39708 1 0.76265 1 0.87494 1 0.092549 0.826 1 1 1 1 0.070455 0.826 USP6 5 (1%) 468 0.078816 0.826 0.23654 0.923 1 1 0.35559 1 0.37858 1 0.25102 0.945 0.23481 0.923 1 1 TPM1 5 (1%) 468 0.12738 0.831 0.38135 1 1 1 NA NA 0.85075 1 1 1 1 1 1 1 GLYAT 4 (1%) 469 0.078935 0.826 0.58322 1 0.63508 1 NA NA 0.8385 1 0.58032 1 1 1 1 1 DIAPH1 4 (1%) 469 0.14593 0.831 0.48875 1 1 1 NA NA 0.14154 0.831 0.58032 1 1 1 1 1 ZMYM2 6 (1%) 467 0.28325 0.988 0.30919 1 0.70008 1 0.70411 1 0.7761 1 0.33106 1 1 1 1 1 HCFC1 7 (1%) 466 0.28636 0.989 0.58031 1 0.0029014 0.184 0.49916 1 0.0301 0.621 1 1 1 1 1 1 MST1 4 (1%) 469 0.12015 0.831 0.321 1 0.036083 0.686 0.94028 1 0.6808 1 0.58032 1 1 1 0.15502 0.831 TNFSF14 5 (1%) 468 0.0034579 0.208 0.055408 0.79 1 1 0.097033 0.826 1 1 0.58837 1 1 1 1 1 DNAH7 10 (2%) 463 0.77566 1 0.057146 0.795 1 1 0.10351 0.831 0.47695 1 0.41719 1 1 1 1 1 ENGASE 3 (1%) 470 0.34435 1 0.66792 1 0.58371 1 NA NA 0.62816 1 0.47818 1 1 1 1 1 MYH8 11 (2%) 462 0.063507 0.82 0.71618 1 0.22397 0.915 0.51887 1 0.18649 0.833 0.45415 1 0.080839 0.826 0.37317 1 VSIG4 6 (1%) 467 0.7497 1 0.94715 1 0.41149 1 NA NA 1 1 0.60209 1 1 1 1 1 KRT3 4 (1%) 469 0.070937 0.826 0.86549 1 0.63508 1 0.42801 1 0.68058 1 0.17174 0.832 1 1 0.15502 0.831 STAG2 4 (1%) 469 0.10352 0.831 0.65857 1 0.32331 1 NA NA 0.13936 0.831 0.58032 1 1 1 1 1 MUC17 24 (5%) 449 0.69872 1 0.14973 0.831 0.30014 1 0.65317 1 0.23317 0.923 1 1 0.26932 0.966 0.61381 1 ABCA7 9 (2%) 464 0.9797 1 0.16258 0.832 0.73753 1 0.41475 1 0.48674 1 0.68897 1 1 1 1 1 FOXK1 4 (1%) 469 0.092402 0.826 0.3365 1 0.32331 1 NA NA 1 1 1 1 1 1 0.15502 0.831 SLFN11 3 (1%) 470 0.17498 0.832 0.068102 0.826 1 1 NA NA 1 1 0.47818 1 1 1 1 1 MX2 4 (1%) 469 0.32325 1 0.02967 0.621 1 1 NA NA 0.6825 1 1 1 1 1 1 1 SLC6A4 4 (1%) 469 0.15836 0.831 0.44921 1 0.32331 1 NA NA 0.1404 0.831 0.17174 0.832 1 1 1 1 KRT15 6 (1%) 467 0.69547 1 0.11715 0.831 0.70008 1 0.34032 1 0.77312 1 0.60209 1 0.2766 0.971 1 1 F8 8 (2%) 465 0.38189 1 0.11573 0.831 0.024041 0.579 0.20497 0.859 0.54028 1 0.18963 0.833 0.04679 0.771 1 1 HOOK1 3 (1%) 470 0.12511 0.831 0.90365 1 0.58371 1 NA NA 0.62825 1 0.098168 0.826 1 1 1 1 FMR1 5 (1%) 468 0.10443 0.831 0.1823 0.833 1 1 0.42801 1 0.096639 0.826 1 1 1 1 1 1 SON 8 (2%) 465 0.9701 1 0.20422 0.859 1 1 0.42535 1 0.43348 1 1 1 1 1 0.25608 0.945 TTC30B 6 (1%) 467 0.16404 0.832 0.15366 0.831 0.70008 1 0.18737 0.833 0.58733 1 1 1 1 1 1 1 FANCD2 7 (1%) 466 0.35611 1 0.097435 0.826 0.70441 1 NA NA 0.34902 1 0.62624 1 1 1 0.25608 0.945 RGL2 4 (1%) 469 0.12631 0.831 0.19364 0.833 1 1 0.12311 0.831 0.13882 0.831 0.58032 1 1 1 1 1 NR1H3 4 (1%) 469 0.13142 0.831 0.49688 1 0.32331 1 NA NA 0.14136 0.831 0.17174 0.832 1 1 0.15502 0.831 TYRP1 4 (1%) 469 0.48531 1 0.50273 1 1 1 NA NA 0.13942 0.831 0.17174 0.832 1 1 1 1 SLC25A5 4 (1%) 469 0.015596 0.47 0.5807 1 0.32331 1 0.42335 1 1 1 0.58032 1 0.1933 0.833 1 1 AGBL1 4 (1%) 469 0.65036 1 0.36208 1 0.63508 1 NA NA 0.19294 0.833 1 1 1 1 1 1 AMPD1 4 (1%) 469 0.90346 1 0.7445 1 1 1 NA NA 0.68293 1 0.58032 1 1 1 1 1 NGEF 5 (1%) 468 0.36076 1 0.90421 1 0.65765 1 0.40985 1 0.30535 1 1 1 1 1 0.014844 0.47 YIPF1 3 (1%) 470 0.17017 0.832 0.95089 1 0.083132 0.826 NA NA 0.62948 1 0.47818 1 1 1 1 1 PDHA1 5 (1%) 468 0.9673 1 0.18832 0.833 0.015618 0.47 0.48305 1 0.30411 1 1 1 1 1 1 1 ASXL2 3 (1%) 470 0.1632 0.832 0.41477 1 0.58371 1 NA NA 0.78759 1 0.098168 0.826 1 1 1 1 HLA-DRA 3 (1%) 470 0.44826 1 0.79228 1 0.083132 0.826 NA NA 0.065889 0.82 0.098168 0.826 0.14891 0.831 1 1 ALPP 4 (1%) 469 0.38663 1 0.91349 1 0.32331 1 0.84987 1 0.29844 1 0.58032 1 0.02129 0.579 0.080593 0.826 CDH3 3 (1%) 470 0.42894 1 0.62071 1 0.083132 0.826 NA NA 0.78935 1 0.47818 1 1 1 1 1 NADSYN1 3 (1%) 470 0.17006 0.832 0.82519 1 0.58371 1 NA NA 0.36217 1 0.47818 1 1 1 1 1 LHFPL1 4 (1%) 469 0.96294 1 0.026635 0.609 0.63508 1 NA NA 1 1 0.58032 1 1 1 1 1 CXCR2 4 (1%) 469 0.82272 1 0.82513 1 0.63508 1 NA NA 0.68237 1 0.17174 0.832 1 1 1 1 SEC14L4 3 (1%) 470 0.6377 1 0.037796 0.686 0.2601 0.947 NA NA 0.62692 1 0.098168 0.826 1 1 1 1 ANKRD17 6 (1%) 467 0.15356 0.831 0.48452 1 0.70008 1 0.17654 0.832 1 1 0.33106 1 0.27553 0.971 1 1 MAST3 5 (1%) 468 0.47582 1 0.68871 1 0.65765 1 0.037697 0.686 0.45192 1 1 1 0.23538 0.923 1 1 AMMECR1 3 (1%) 470 0.65952 1 0.93737 1 0.58371 1 0.86846 1 0.6275 1 0.098168 0.826 1 1 1 1 NEO1 7 (1%) 466 0.057942 0.795 0.1396 0.831 0.24846 0.945 NA NA 0.55907 1 1 1 1 1 1 1 IGSF8 3 (1%) 470 0.15654 0.831 0.38158 1 0.58371 1 NA NA 0.6282 1 0.098168 0.826 1 1 1 1 RGS3 5 (1%) 468 0.33511 1 0.48661 1 0.65765 1 0.30308 1 0.0077199 0.292 1 1 1 1 0.19007 0.833