Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.103 0.293 -9999.0 0.0 -0.717 65.0 65.0 IHH -0.014 0.086 -9999.0 0.0 -0.481 10.0 10.0 SHH Np/Cholesterol/GAS1 -0.069 0.16 -9999.0 0.0 -0.361 83.0 83.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.086 0.148 0.358 83.0 -9999.0 0.0 83.0 SMO/beta Arrestin2 -0.036 0.174 -9999.0 0.0 -0.646 19.0 19.0 SMO -0.046 0.184 -9999.0 0.0 -0.626 24.0 24.0 AKT1 0.002 0.083 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.062 -9999.0 0.0 -0.558 6.0 6.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.045 0.181 -9999.0 0.0 -0.613 24.0 24.0 STIL -0.092 0.217 -9999.0 0.0 -0.524 74.0 74.0 DHH N/PTCH2 -0.058 0.144 -9999.0 0.0 -0.404 74.0 74.0 DHH N/PTCH1 -0.069 0.193 -9999.0 0.0 -0.534 39.0 39.0 PIK3CA 0.013 0.027 -9999.0 0.0 -0.593 1.0 1.0 DHH -0.047 0.174 -9999.0 0.0 -0.543 56.0 56.0 PTHLH -0.114 0.344 -9999.0 0.0 -0.922 63.0 63.0 determination of left/right symmetry -0.045 0.181 -9999.0 0.0 -0.613 24.0 24.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.112 0.339 -9999.0 0.0 -0.907 63.0 63.0 IHH N/Hhip -0.116 0.21 -9999.0 0.0 -0.441 147.0 147.0 DHH N/Hhip -0.147 0.211 -9999.0 0.0 -0.422 180.0 180.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.045 0.181 -9999.0 0.0 -0.613 24.0 24.0 pancreas development -0.14 0.251 -9999.0 0.0 -0.545 142.0 142.0 HHAT -0.006 0.108 -9999.0 0.0 -0.576 18.0 18.0 PI3K -0.001 0.019 -9999.0 0.0 -0.429 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.014 0.117 -9999.0 0.0 -0.501 28.0 28.0 somite specification -0.045 0.181 -9999.0 0.0 -0.613 24.0 24.0 SHH Np/Cholesterol/PTCH1 -0.093 0.213 -9999.0 0.0 -0.536 64.0 64.0 SHH Np/Cholesterol/PTCH2 -0.067 0.157 -9999.0 0.0 -0.348 86.0 86.0 SHH Np/Cholesterol/Megalin -0.168 0.217 -9999.0 0.0 -0.421 165.0 165.0 SHH -0.079 0.188 -9999.0 0.0 -0.406 123.0 123.0 catabolic process -0.047 0.184 -9999.0 0.0 -0.548 32.0 32.0 SMO/Vitamin D3 -0.084 0.216 -9999.0 0.0 -0.563 54.0 54.0 SHH Np/Cholesterol/Hhip -0.139 0.211 -9999.0 0.0 -0.42 134.0 134.0 LRP2 -0.191 0.273 -9999.0 0.0 -0.551 187.0 187.0 receptor-mediated endocytosis -0.179 0.219 -9999.0 0.0 -0.555 97.0 97.0 SHH Np/Cholesterol/BOC -0.057 0.152 -9999.0 0.0 -0.314 126.0 126.0 SHH Np/Cholesterol/CDO -0.075 0.168 -9999.0 0.0 -0.373 91.0 91.0 mesenchymal cell differentiation 0.152 0.198 0.417 134.0 -9999.0 0.0 134.0 mol:Vitamin D3 -0.091 0.215 -9999.0 0.0 -0.536 64.0 64.0 IHH N/PTCH2 -0.011 0.106 -9999.0 0.0 -0.413 30.0 30.0 CDON -0.025 0.144 -9999.0 0.0 -0.558 35.0 35.0 IHH N/PTCH1 -0.047 0.185 -9999.0 0.0 -0.552 32.0 32.0 Megalin/LRPAP1 -0.142 0.191 -9999.0 0.0 -0.393 187.0 187.0 PTCH2 -0.009 0.114 -9999.0 0.0 -0.558 21.0 21.0 SHH Np/Cholesterol -0.075 0.139 -9999.0 0.0 -0.315 123.0 123.0 PTCH1 -0.047 0.185 -9999.0 0.0 -0.55 32.0 32.0 HHIP -0.14 0.252 -9999.0 0.0 -0.546 142.0 142.0