This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 12 different clustering approaches and 15 clinical features across 518 patients, 54 significant findings detected with P value < 0.05 and Q value < 0.25.
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CNMF clustering analysis on array-based mRNA expression data identified 4 subtypes that correlate to 'NEOPLASM_DISEASESTAGE'.
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Consensus hierarchical clustering analysis on array-based mRNA expression data identified 3 subtypes that correlate to 'NEOPLASM_DISEASESTAGE' and 'RACE'.
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4 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'GENDER', and 'NUMBER_PACK_YEARS_SMOKED'.
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3 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'GENDER', 'NUMBER_PACK_YEARS_SMOKED', and 'ETHNICITY'.
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CNMF clustering analysis on RPPA data identified 3 subtypes that correlate to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.
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Consensus hierarchical clustering analysis on RPPA data identified 5 subtypes that correlate to 'GENDER', 'HISTOLOGICAL_TYPE', 'NUMBER_PACK_YEARS_SMOKED', and 'YEAR_OF_TOBACCO_SMOKING_ONSET'.
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CNMF clustering analysis on sequencing-based mRNA expression data identified 3 subtypes that correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'GENDER', and 'HISTOLOGICAL_TYPE'.
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Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 7 subtypes that correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'GENDER', 'HISTOLOGICAL_TYPE', 'NUMBER_PACK_YEARS_SMOKED', 'YEAR_OF_TOBACCO_SMOKING_ONSET', and 'ETHNICITY'.
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3 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes correlate to 'YEARS_TO_BIRTH', 'NEOPLASM_DISEASESTAGE', 'PATHOLOGY_T_STAGE', 'HISTOLOGICAL_TYPE', and 'YEAR_OF_TOBACCO_SMOKING_ONSET'.
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4 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes correlate to 'YEARS_TO_BIRTH', 'GENDER', 'HISTOLOGICAL_TYPE', 'NUMBER_PACK_YEARS_SMOKED', and 'YEAR_OF_TOBACCO_SMOKING_ONSET'.
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3 subtypes identified in current cancer cohort by 'MIRseq Mature CNMF subtypes'. These subtypes correlate to 'PATHOLOGY_T_STAGE', 'HISTOLOGICAL_TYPE', 'RADIATIONS_RADIATION_REGIMENINDICATION', and 'NUMBER_PACK_YEARS_SMOKED'.
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3 subtypes identified in current cancer cohort by 'MIRseq Mature cHierClus subtypes'. These subtypes correlate to 'YEARS_TO_BIRTH', 'PATHOLOGY_T_STAGE', 'GENDER', 'HISTOLOGICAL_TYPE', and 'YEAR_OF_TOBACCO_SMOKING_ONSET'.
Clinical Features |
Statistical Tests |
mRNA CNMF subtypes |
mRNA cHierClus subtypes |
Copy Number Ratio CNMF subtypes |
METHLYATION CNMF |
RPPA CNMF subtypes |
RPPA cHierClus subtypes |
RNAseq CNMF subtypes |
RNAseq cHierClus subtypes |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRseq Mature CNMF subtypes |
MIRseq Mature cHierClus subtypes |
Time to Death | logrank test |
0.75 (0.871) |
0.925 (0.991) |
0.0192 (0.0825) |
0.139 (0.324) |
0.459 (0.663) |
0.329 (0.565) |
0.00333 (0.024) |
2.5e-07 (4.51e-05) |
0.178 (0.381) |
0.817 (0.919) |
0.267 (0.494) |
0.0545 (0.179) |
YEARS TO BIRTH | Kruskal-Wallis (anova) |
0.65 (0.812) |
0.513 (0.684) |
0.00156 (0.0134) |
0.206 (0.422) |
0.0437 (0.154) |
0.242 (0.465) |
0.0479 (0.16) |
0.000674 (0.00933) |
0.0102 (0.0508) |
0.00155 (0.0134) |
0.657 (0.816) |
2.92e-06 (0.000263) |
NEOPLASM DISEASESTAGE | Fisher's exact test |
0.0466 (0.158) |
0.0359 (0.135) |
0.101 (0.27) |
0.00023 (0.00414) |
0.67 (0.816) |
0.121 (0.294) |
0.00368 (0.0255) |
0.00119 (0.0126) |
0.00131 (0.0126) |
0.59 (0.758) |
0.476 (0.675) |
0.398 (0.634) |
PATHOLOGY T STAGE | Fisher's exact test |
0.512 (0.684) |
0.275 (0.494) |
0.114 (0.285) |
0.00112 (0.0126) |
0.877 (0.961) |
0.0734 (0.228) |
0.00175 (0.0143) |
0.00093 (0.0112) |
0.0172 (0.0794) |
0.135 (0.319) |
0.015 (0.0731) |
0.00931 (0.0493) |
PATHOLOGY N STAGE | Fisher's exact test |
0.484 (0.68) |
0.456 (0.663) |
0.25 (0.474) |
0.0617 (0.198) |
0.881 (0.961) |
0.309 (0.54) |
0.0279 (0.117) |
0.00293 (0.022) |
0.276 (0.494) |
0.716 (0.842) |
0.191 (0.395) |
0.0695 (0.22) |
PATHOLOGY M STAGE | Fisher's exact test |
0.504 (0.684) |
0.491 (0.684) |
0.18 (0.381) |
0.26 (0.487) |
0.277 (0.494) |
0.394 (0.634) |
0.447 (0.663) |
0.513 (0.684) |
0.55 (0.722) |
0.846 (0.946) |
0.434 (0.663) |
0.582 (0.753) |
GENDER | Fisher's exact test |
0.275 (0.494) |
0.671 (0.816) |
0.019 (0.0825) |
4e-05 (0.0012) |
0.0988 (0.27) |
0.00628 (0.0377) |
1e-05 (0.00036) |
1e-05 (0.00036) |
0.476 (0.675) |
0.0046 (0.0296) |
0.96 (1.00) |
0.00045 (0.00736) |
KARNOFSKY PERFORMANCE SCORE | Kruskal-Wallis (anova) |
0.095 (0.267) |
0.862 (0.957) |
0.154 (0.355) |
0.12 (0.294) |
0.228 (0.447) |
0.0947 (0.267) |
0.685 (0.822) |
0.715 (0.842) |
0.109 (0.276) |
0.668 (0.816) |
||
HISTOLOGICAL TYPE | Fisher's exact test |
0.435 (0.663) |
0.396 (0.634) |
0.394 (0.634) |
0.127 (0.305) |
0.00801 (0.0465) |
0.0192 (0.0825) |
1e-05 (0.00036) |
0.00018 (0.0036) |
0.00075 (0.00964) |
0.00133 (0.0126) |
5e-05 (0.00129) |
7e-05 (0.00157) |
RADIATIONS RADIATION REGIMENINDICATION | Fisher's exact test |
1 (1.00) |
1 (1.00) |
0.213 (0.431) |
0.159 (0.357) |
0.291 (0.514) |
0.776 (0.89) |
0.925 (0.991) |
0.18 (0.381) |
1 (1.00) |
0.782 (0.891) |
0.0325 (0.127) |
0.0923 (0.267) |
NUMBER PACK YEARS SMOKED | Kruskal-Wallis (anova) |
0.46 (0.663) |
0.362 (0.604) |
0.0303 (0.124) |
0.00402 (0.0268) |
0.109 (0.276) |
0.031 (0.124) |
0.0931 (0.267) |
0.0416 (0.15) |
0.0797 (0.239) |
0.0407 (0.15) |
0.00889 (0.049) |
0.224 (0.442) |
YEAR OF TOBACCO SMOKING ONSET | Kruskal-Wallis (anova) |
0.715 (0.842) |
0.676 (0.817) |
0.173 (0.381) |
0.888 (0.963) |
0.416 (0.656) |
0.00899 (0.049) |
0.355 (0.597) |
0.000498 (0.00747) |
0.017 (0.0794) |
0.00525 (0.0326) |
0.506 (0.684) |
0.00232 (0.0182) |
COMPLETENESS OF RESECTION | Fisher's exact test |
0.533 (0.705) |
0.456 (0.663) |
0.877 (0.961) |
0.8 (0.906) |
0.454 (0.663) |
0.747 (0.871) |
0.648 (0.812) |
0.243 (0.465) |
0.451 (0.663) |
0.954 (1.00) |
0.158 (0.357) |
0.0999 (0.27) |
RACE | Fisher's exact test |
0.0787 (0.239) |
0.00972 (0.05) |
0.562 (0.733) |
0.184 (0.386) |
0.334 (0.567) |
0.174 (0.381) |
0.972 (1.00) |
0.6 (0.767) |
0.441 (0.663) |
0.316 (0.546) |
0.95 (1.00) |
0.103 (0.27) |
ETHNICITY | Fisher's exact test |
1 (1.00) |
1 (1.00) |
0.221 (0.442) |
0.0445 (0.154) |
1 (1.00) |
0.632 (0.802) |
0.497 (0.684) |
0.0351 (0.135) |
0.366 (0.605) |
0.757 (0.874) |
0.102 (0.27) |
0.454 (0.663) |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 5 | 9 | 12 | 6 |
P value = 0.75 (logrank test), Q value = 0.87
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 31 | 6 | 0.5 - 56.8 (25.0) |
subtype1 | 4 | 0 | 6.0 - 48.6 (24.5) |
subtype2 | 9 | 2 | 4.0 - 56.8 (38.2) |
subtype3 | 12 | 2 | 0.5 - 44.9 (16.4) |
subtype4 | 6 | 2 | 20.1 - 45.2 (30.9) |
P value = 0.65 (Kruskal-Wallis (anova)), Q value = 0.81
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 30 | 65.7 (10.8) |
subtype1 | 4 | 58.5 (15.5) |
subtype2 | 9 | 65.0 (9.1) |
subtype3 | 12 | 67.1 (11.1) |
subtype4 | 5 | 69.4 (9.0) |
P value = 0.0466 (Fisher's exact test), Q value = 0.16
nPatients | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IV |
---|---|---|---|---|---|---|
ALL | 12 | 11 | 1 | 3 | 3 | 2 |
subtype1 | 3 | 0 | 0 | 1 | 0 | 1 |
subtype2 | 4 | 4 | 0 | 0 | 1 | 0 |
subtype3 | 3 | 7 | 0 | 1 | 0 | 1 |
subtype4 | 2 | 0 | 1 | 1 | 2 | 0 |
P value = 0.512 (Fisher's exact test), Q value = 0.68
nPatients | T1 | T2 | T3 |
---|---|---|---|
ALL | 12 | 19 | 1 |
subtype1 | 3 | 2 | 0 |
subtype2 | 4 | 4 | 1 |
subtype3 | 4 | 8 | 0 |
subtype4 | 1 | 5 | 0 |
P value = 0.484 (Fisher's exact test), Q value = 0.68
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 23 | 4 | 4 |
subtype1 | 3 | 1 | 1 |
subtype2 | 8 | 1 | 0 |
subtype3 | 9 | 1 | 1 |
subtype4 | 3 | 1 | 2 |
P value = 0.504 (Fisher's exact test), Q value = 0.68
nPatients | 0 | 1 |
---|---|---|
ALL | 30 | 2 |
subtype1 | 4 | 1 |
subtype2 | 9 | 0 |
subtype3 | 11 | 1 |
subtype4 | 6 | 0 |
P value = 0.275 (Fisher's exact test), Q value = 0.49
nPatients | FEMALE | MALE |
---|---|---|
ALL | 18 | 14 |
subtype1 | 3 | 2 |
subtype2 | 3 | 6 |
subtype3 | 9 | 3 |
subtype4 | 3 | 3 |
P value = 0.435 (Fisher's exact test), Q value = 0.66
nPatients | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG CLEAR CELL ADENOCARCINOMA |
---|---|---|---|
ALL | 1 | 30 | 1 |
subtype1 | 0 | 4 | 1 |
subtype2 | 0 | 9 | 0 |
subtype3 | 1 | 11 | 0 |
subtype4 | 0 | 6 | 0 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 1 | 31 |
subtype1 | 0 | 5 |
subtype2 | 0 | 9 |
subtype3 | 1 | 11 |
subtype4 | 0 | 6 |
P value = 0.46 (Kruskal-Wallis (anova)), Q value = 0.66
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 20 | 41.1 (15.0) |
subtype1 | 2 | 29.0 (12.7) |
subtype2 | 9 | 47.0 (15.5) |
subtype3 | 6 | 37.0 (13.1) |
subtype4 | 3 | 40.0 (17.3) |
P value = 0.715 (Kruskal-Wallis (anova)), Q value = 0.84
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 19 | 1968.5 (11.4) |
subtype1 | 2 | 1977.0 (18.4) |
subtype2 | 6 | 1971.2 (14.2) |
subtype3 | 6 | 1965.8 (8.2) |
subtype4 | 5 | 1965.2 (9.8) |
P value = 0.533 (Fisher's exact test), Q value = 0.71
nPatients | R0 | R2 | RX |
---|---|---|---|
ALL | 26 | 1 | 2 |
subtype1 | 3 | 0 | 1 |
subtype2 | 7 | 1 | 0 |
subtype3 | 10 | 0 | 1 |
subtype4 | 6 | 0 | 0 |
P value = 0.0787 (Fisher's exact test), Q value = 0.24
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 1 | 26 |
subtype1 | 1 | 0 | 3 |
subtype2 | 0 | 0 | 7 |
subtype3 | 0 | 0 | 12 |
subtype4 | 1 | 1 | 4 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 1 | 28 |
subtype1 | 0 | 4 |
subtype2 | 0 | 7 |
subtype3 | 1 | 11 |
subtype4 | 0 | 6 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 14 | 11 | 7 |
P value = 0.925 (logrank test), Q value = 0.99
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 31 | 6 | 0.5 - 56.8 (25.0) |
subtype1 | 13 | 2 | 0.5 - 47.0 (18.8) |
subtype2 | 11 | 2 | 4.0 - 56.8 (34.1) |
subtype3 | 7 | 2 | 20.1 - 48.6 (38.7) |
P value = 0.513 (Kruskal-Wallis (anova)), Q value = 0.68
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 30 | 65.7 (10.8) |
subtype1 | 14 | 66.7 (10.5) |
subtype2 | 11 | 62.7 (12.0) |
subtype3 | 5 | 69.4 (9.0) |
P value = 0.0359 (Fisher's exact test), Q value = 0.13
nPatients | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IV |
---|---|---|---|---|---|---|
ALL | 12 | 11 | 1 | 3 | 3 | 2 |
subtype1 | 3 | 8 | 0 | 1 | 0 | 2 |
subtype2 | 6 | 3 | 0 | 1 | 1 | 0 |
subtype3 | 3 | 0 | 1 | 1 | 2 | 0 |
P value = 0.275 (Fisher's exact test), Q value = 0.49
nPatients | T1 | T2 | T3 |
---|---|---|---|
ALL | 12 | 19 | 1 |
subtype1 | 4 | 10 | 0 |
subtype2 | 6 | 4 | 1 |
subtype3 | 2 | 5 | 0 |
P value = 0.456 (Fisher's exact test), Q value = 0.66
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 23 | 4 | 4 |
subtype1 | 10 | 1 | 2 |
subtype2 | 9 | 2 | 0 |
subtype3 | 4 | 1 | 2 |
P value = 0.491 (Fisher's exact test), Q value = 0.68
nPatients | 0 | 1 |
---|---|---|
ALL | 30 | 2 |
subtype1 | 12 | 2 |
subtype2 | 11 | 0 |
subtype3 | 7 | 0 |
P value = 0.671 (Fisher's exact test), Q value = 0.82
nPatients | FEMALE | MALE |
---|---|---|
ALL | 18 | 14 |
subtype1 | 9 | 5 |
subtype2 | 5 | 6 |
subtype3 | 4 | 3 |
P value = 0.396 (Fisher's exact test), Q value = 0.63
nPatients | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG CLEAR CELL ADENOCARCINOMA |
---|---|---|---|
ALL | 1 | 30 | 1 |
subtype1 | 1 | 13 | 0 |
subtype2 | 0 | 11 | 0 |
subtype3 | 0 | 6 | 1 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 1 | 31 |
subtype1 | 1 | 13 |
subtype2 | 0 | 11 |
subtype3 | 0 | 7 |
P value = 0.362 (Kruskal-Wallis (anova)), Q value = 0.6
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 20 | 41.1 (15.0) |
subtype1 | 8 | 35.4 (12.2) |
subtype2 | 9 | 46.7 (16.1) |
subtype3 | 3 | 40.0 (17.3) |
P value = 0.676 (Kruskal-Wallis (anova)), Q value = 0.82
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 19 | 1968.5 (11.4) |
subtype1 | 7 | 1969.9 (13.0) |
subtype2 | 6 | 1970.5 (12.9) |
subtype3 | 6 | 1965.0 (8.8) |
P value = 0.456 (Fisher's exact test), Q value = 0.66
nPatients | R0 | R2 | RX |
---|---|---|---|
ALL | 26 | 1 | 2 |
subtype1 | 10 | 0 | 2 |
subtype2 | 10 | 1 | 0 |
subtype3 | 6 | 0 | 0 |
P value = 0.00972 (Fisher's exact test), Q value = 0.05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 1 | 26 |
subtype1 | 0 | 0 | 13 |
subtype2 | 0 | 0 | 9 |
subtype3 | 2 | 1 | 4 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 1 | 28 |
subtype1 | 1 | 12 |
subtype2 | 0 | 9 |
subtype3 | 0 | 7 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 69 | 228 | 78 | 140 |
P value = 0.0192 (logrank test), Q value = 0.082
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 491 | 154 | 0.0 - 224.0 (18.6) |
subtype1 | 65 | 18 | 0.1 - 88.1 (15.7) |
subtype2 | 217 | 56 | 0.1 - 224.0 (18.2) |
subtype3 | 75 | 31 | 0.0 - 86.1 (16.4) |
subtype4 | 134 | 49 | 0.1 - 214.6 (19.4) |
P value = 0.00156 (Kruskal-Wallis (anova)), Q value = 0.013
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 484 | 65.2 (10.0) |
subtype1 | 65 | 64.4 (11.0) |
subtype2 | 213 | 67.2 (8.9) |
subtype3 | 74 | 64.9 (10.8) |
subtype4 | 132 | 62.7 (10.2) |
P value = 0.101 (Fisher's exact test), Q value = 0.27
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IV |
---|---|---|---|---|---|---|---|---|---|
ALL | 5 | 135 | 140 | 1 | 51 | 73 | 72 | 11 | 26 |
subtype1 | 0 | 21 | 17 | 0 | 4 | 7 | 13 | 2 | 5 |
subtype2 | 2 | 75 | 63 | 1 | 20 | 28 | 27 | 3 | 8 |
subtype3 | 1 | 15 | 18 | 0 | 7 | 17 | 11 | 2 | 7 |
subtype4 | 2 | 24 | 42 | 0 | 20 | 21 | 21 | 4 | 6 |
P value = 0.114 (Fisher's exact test), Q value = 0.29
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 170 | 278 | 46 | 19 |
subtype1 | 24 | 36 | 5 | 4 |
subtype2 | 90 | 112 | 16 | 9 |
subtype3 | 19 | 45 | 11 | 2 |
subtype4 | 37 | 85 | 14 | 4 |
P value = 0.25 (Fisher's exact test), Q value = 0.47
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 332 | 96 | 76 |
subtype1 | 48 | 8 | 12 |
subtype2 | 154 | 40 | 27 |
subtype3 | 49 | 16 | 12 |
subtype4 | 81 | 32 | 25 |
P value = 0.18 (Fisher's exact test), Q value = 0.38
nPatients | 0 | 1 |
---|---|---|
ALL | 348 | 25 |
subtype1 | 51 | 5 |
subtype2 | 156 | 7 |
subtype3 | 51 | 7 |
subtype4 | 90 | 6 |
P value = 0.019 (Fisher's exact test), Q value = 0.082
nPatients | FEMALE | MALE |
---|---|---|
ALL | 275 | 240 |
subtype1 | 28 | 41 |
subtype2 | 128 | 100 |
subtype3 | 35 | 43 |
subtype4 | 84 | 56 |
P value = 0.095 (Kruskal-Wallis (anova)), Q value = 0.27
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 98 | 85.1 (20.8) |
subtype1 | 13 | 86.2 (27.2) |
subtype2 | 34 | 91.2 (6.9) |
subtype3 | 16 | 83.1 (25.0) |
subtype4 | 35 | 79.7 (24.1) |
P value = 0.394 (Fisher's exact test), Q value = 0.63
nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SIGNET RING ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) CARCINOMA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 19 | 107 | 319 | 5 | 19 | 2 | 3 | 2 | 23 | 1 | 5 | 10 |
subtype1 | 6 | 14 | 41 | 0 | 1 | 0 | 0 | 0 | 7 | 0 | 0 | 0 |
subtype2 | 7 | 50 | 132 | 3 | 11 | 1 | 1 | 2 | 10 | 1 | 3 | 7 |
subtype3 | 2 | 14 | 54 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 1 | 3 |
subtype4 | 4 | 29 | 92 | 2 | 6 | 0 | 2 | 0 | 4 | 0 | 1 | 0 |
P value = 0.213 (Fisher's exact test), Q value = 0.43
nPatients | NO | YES |
---|---|---|
ALL | 21 | 494 |
subtype1 | 5 | 64 |
subtype2 | 6 | 222 |
subtype3 | 5 | 73 |
subtype4 | 5 | 135 |
P value = 0.0303 (Kruskal-Wallis (anova)), Q value = 0.12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 355 | 41.6 (27.3) |
subtype1 | 54 | 40.7 (28.1) |
subtype2 | 152 | 38.2 (26.3) |
subtype3 | 55 | 41.9 (25.5) |
subtype4 | 94 | 47.5 (28.8) |
P value = 0.173 (Kruskal-Wallis (anova)), Q value = 0.38
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 276 | 1965.0 (12.6) |
subtype1 | 43 | 1965.9 (13.6) |
subtype2 | 119 | 1963.5 (12.1) |
subtype3 | 41 | 1968.3 (12.6) |
subtype4 | 73 | 1965.1 (12.5) |
P value = 0.877 (Fisher's exact test), Q value = 0.96
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 343 | 12 | 4 | 26 |
subtype1 | 43 | 2 | 0 | 5 |
subtype2 | 146 | 3 | 2 | 12 |
subtype3 | 55 | 2 | 1 | 3 |
subtype4 | 99 | 5 | 1 | 6 |
P value = 0.562 (Fisher's exact test), Q value = 0.73
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 7 | 51 | 389 |
subtype1 | 0 | 2 | 5 | 53 |
subtype2 | 0 | 2 | 20 | 180 |
subtype3 | 0 | 1 | 10 | 55 |
subtype4 | 1 | 2 | 16 | 101 |
P value = 0.221 (Fisher's exact test), Q value = 0.44
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 7 | 382 |
subtype1 | 1 | 51 |
subtype2 | 2 | 177 |
subtype3 | 3 | 55 |
subtype4 | 1 | 99 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 145 | 148 | 164 |
P value = 0.139 (logrank test), Q value = 0.32
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 434 | 133 | 0.1 - 224.0 (17.6) |
subtype1 | 137 | 33 | 0.1 - 224.0 (18.7) |
subtype2 | 141 | 53 | 0.1 - 214.6 (17.6) |
subtype3 | 156 | 47 | 0.1 - 163.1 (16.1) |
P value = 0.206 (Kruskal-Wallis (anova)), Q value = 0.42
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 428 | 65.0 (10.2) |
subtype1 | 134 | 66.0 (9.7) |
subtype2 | 140 | 63.9 (10.4) |
subtype3 | 154 | 65.2 (10.3) |
P value = 0.00023 (Fisher's exact test), Q value = 0.0041
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IV |
---|---|---|---|---|---|---|---|---|---|
ALL | 5 | 120 | 125 | 1 | 48 | 63 | 64 | 9 | 21 |
subtype1 | 1 | 57 | 34 | 1 | 16 | 17 | 12 | 1 | 5 |
subtype2 | 4 | 36 | 36 | 0 | 17 | 15 | 26 | 4 | 10 |
subtype3 | 0 | 27 | 55 | 0 | 15 | 31 | 26 | 4 | 6 |
P value = 0.00112 (Fisher's exact test), Q value = 0.013
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 154 | 243 | 41 | 16 |
subtype1 | 68 | 62 | 10 | 3 |
subtype2 | 48 | 83 | 11 | 5 |
subtype3 | 38 | 98 | 20 | 8 |
P value = 0.0617 (Fisher's exact test), Q value = 0.2
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 298 | 83 | 66 |
subtype1 | 101 | 25 | 12 |
subtype2 | 92 | 24 | 30 |
subtype3 | 105 | 34 | 24 |
P value = 0.26 (Fisher's exact test), Q value = 0.49
nPatients | 0 | 1 |
---|---|---|
ALL | 294 | 19 |
subtype1 | 84 | 4 |
subtype2 | 98 | 10 |
subtype3 | 112 | 5 |
P value = 4e-05 (Fisher's exact test), Q value = 0.0012
nPatients | FEMALE | MALE |
---|---|---|
ALL | 243 | 214 |
subtype1 | 97 | 48 |
subtype2 | 59 | 89 |
subtype3 | 87 | 77 |
P value = 0.862 (Kruskal-Wallis (anova)), Q value = 0.96
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 92 | 85.0 (19.9) |
subtype1 | 25 | 86.4 (19.6) |
subtype2 | 37 | 83.2 (24.0) |
subtype3 | 30 | 86.0 (14.0) |
P value = 0.127 (Fisher's exact test), Q value = 0.3
nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SIGNET RING ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) CARCINOMA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 19 | 92 | 279 | 5 | 19 | 1 | 2 | 2 | 22 | 1 | 5 | 10 |
subtype1 | 5 | 23 | 88 | 4 | 8 | 0 | 1 | 2 | 7 | 1 | 0 | 6 |
subtype2 | 8 | 29 | 92 | 0 | 3 | 1 | 0 | 0 | 9 | 0 | 3 | 3 |
subtype3 | 6 | 40 | 99 | 1 | 8 | 0 | 1 | 0 | 6 | 0 | 2 | 1 |
P value = 0.159 (Fisher's exact test), Q value = 0.36
nPatients | NO | YES |
---|---|---|
ALL | 18 | 439 |
subtype1 | 6 | 139 |
subtype2 | 9 | 139 |
subtype3 | 3 | 161 |
P value = 0.00402 (Kruskal-Wallis (anova)), Q value = 0.027
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 313 | 40.7 (27.3) |
subtype1 | 91 | 37.4 (24.6) |
subtype2 | 110 | 47.4 (29.6) |
subtype3 | 112 | 36.8 (25.9) |
P value = 0.888 (Kruskal-Wallis (anova)), Q value = 0.96
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 251 | 1965.3 (12.5) |
subtype1 | 72 | 1964.7 (11.4) |
subtype2 | 88 | 1965.8 (12.9) |
subtype3 | 91 | 1965.2 (13.0) |
P value = 0.8 (Fisher's exact test), Q value = 0.91
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 293 | 10 | 1 | 23 |
subtype1 | 87 | 2 | 1 | 9 |
subtype2 | 94 | 4 | 0 | 6 |
subtype3 | 112 | 4 | 0 | 8 |
P value = 0.184 (Fisher's exact test), Q value = 0.39
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 6 | 49 | 352 |
subtype1 | 0 | 18 | 114 |
subtype2 | 2 | 19 | 114 |
subtype3 | 4 | 12 | 124 |
P value = 0.0445 (Fisher's exact test), Q value = 0.15
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 7 | 341 |
subtype1 | 2 | 118 |
subtype2 | 5 | 108 |
subtype3 | 0 | 115 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 44 | 73 | 64 |
P value = 0.459 (logrank test), Q value = 0.66
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 168 | 63 | 0.1 - 224.0 (20.1) |
subtype1 | 43 | 15 | 0.5 - 163.1 (19.3) |
subtype2 | 65 | 22 | 0.1 - 70.5 (17.6) |
subtype3 | 60 | 26 | 0.1 - 224.0 (20.6) |
P value = 0.0437 (Kruskal-Wallis (anova)), Q value = 0.15
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 164 | 65.5 (9.6) |
subtype1 | 43 | 67.0 (8.6) |
subtype2 | 63 | 63.3 (10.1) |
subtype3 | 58 | 66.7 (9.5) |
P value = 0.67 (Fisher's exact test), Q value = 0.82
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IV |
---|---|---|---|---|---|---|---|---|
ALL | 1 | 41 | 52 | 15 | 25 | 33 | 7 | 7 |
subtype1 | 0 | 12 | 9 | 6 | 7 | 6 | 1 | 3 |
subtype2 | 1 | 17 | 20 | 5 | 12 | 14 | 2 | 2 |
subtype3 | 0 | 12 | 23 | 4 | 6 | 13 | 4 | 2 |
P value = 0.877 (Fisher's exact test), Q value = 0.96
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 48 | 108 | 13 | 12 |
subtype1 | 12 | 27 | 2 | 3 |
subtype2 | 20 | 43 | 7 | 3 |
subtype3 | 16 | 38 | 4 | 6 |
P value = 0.881 (Fisher's exact test), Q value = 0.96
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 106 | 34 | 35 |
subtype1 | 27 | 9 | 7 |
subtype2 | 40 | 15 | 14 |
subtype3 | 39 | 10 | 14 |
P value = 0.277 (Fisher's exact test), Q value = 0.49
nPatients | 0 | 1 |
---|---|---|
ALL | 137 | 6 |
subtype1 | 30 | 3 |
subtype2 | 57 | 2 |
subtype3 | 50 | 1 |
P value = 0.0988 (Fisher's exact test), Q value = 0.27
nPatients | FEMALE | MALE |
---|---|---|
ALL | 105 | 76 |
subtype1 | 20 | 24 |
subtype2 | 48 | 25 |
subtype3 | 37 | 27 |
P value = 0.154 (Kruskal-Wallis (anova)), Q value = 0.36
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 14 | 60.0 (40.6) |
subtype1 | 6 | 83.3 (8.2) |
subtype2 | 5 | 30.0 (42.4) |
subtype3 | 3 | 63.3 (55.1) |
P value = 0.00801 (Fisher's exact test), Q value = 0.047
nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | MUCINOUS (COLLOID) CARCINOMA |
---|---|---|---|---|---|---|---|---|---|
ALL | 5 | 43 | 111 | 3 | 8 | 2 | 1 | 5 | 3 |
subtype1 | 3 | 15 | 17 | 0 | 5 | 1 | 0 | 2 | 1 |
subtype2 | 2 | 14 | 51 | 0 | 2 | 1 | 1 | 1 | 1 |
subtype3 | 0 | 14 | 43 | 3 | 1 | 0 | 0 | 2 | 1 |
P value = 0.291 (Fisher's exact test), Q value = 0.51
nPatients | NO | YES |
---|---|---|
ALL | 13 | 168 |
subtype1 | 3 | 41 |
subtype2 | 3 | 70 |
subtype3 | 7 | 57 |
P value = 0.109 (Kruskal-Wallis (anova)), Q value = 0.28
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 127 | 41.8 (27.1) |
subtype1 | 38 | 35.3 (23.7) |
subtype2 | 38 | 44.1 (32.0) |
subtype3 | 51 | 44.9 (25.3) |
P value = 0.416 (Kruskal-Wallis (anova)), Q value = 0.66
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 95 | 1961.8 (12.8) |
subtype1 | 29 | 1959.6 (12.4) |
subtype2 | 29 | 1964.5 (13.1) |
subtype3 | 37 | 1961.3 (12.8) |
P value = 0.454 (Fisher's exact test), Q value = 0.66
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 119 | 8 | 1 | 5 |
subtype1 | 30 | 3 | 0 | 1 |
subtype2 | 47 | 3 | 1 | 4 |
subtype3 | 42 | 2 | 0 | 0 |
P value = 0.334 (Fisher's exact test), Q value = 0.57
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 6 | 141 |
subtype1 | 0 | 3 | 36 |
subtype2 | 2 | 1 | 52 |
subtype3 | 0 | 2 | 53 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 2 | 106 |
subtype1 | 0 | 28 |
subtype2 | 1 | 42 |
subtype3 | 1 | 36 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 40 | 33 | 45 | 31 | 32 |
P value = 0.329 (logrank test), Q value = 0.56
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 168 | 63 | 0.1 - 224.0 (20.1) |
subtype1 | 38 | 13 | 0.1 - 163.1 (18.5) |
subtype2 | 31 | 11 | 0.1 - 224.0 (22.7) |
subtype3 | 41 | 18 | 0.8 - 78.7 (23.2) |
subtype4 | 28 | 14 | 0.8 - 64.9 (16.1) |
subtype5 | 30 | 7 | 0.6 - 120.8 (15.1) |
P value = 0.242 (Kruskal-Wallis (anova)), Q value = 0.46
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 164 | 65.5 (9.6) |
subtype1 | 38 | 64.7 (9.0) |
subtype2 | 30 | 64.7 (9.5) |
subtype3 | 38 | 64.1 (10.4) |
subtype4 | 28 | 65.9 (9.8) |
subtype5 | 30 | 68.7 (9.1) |
P value = 0.121 (Fisher's exact test), Q value = 0.29
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IV |
---|---|---|---|---|---|---|---|---|
ALL | 1 | 41 | 52 | 15 | 25 | 33 | 7 | 7 |
subtype1 | 1 | 16 | 12 | 3 | 3 | 3 | 0 | 2 |
subtype2 | 0 | 7 | 12 | 1 | 3 | 5 | 2 | 3 |
subtype3 | 0 | 5 | 14 | 4 | 9 | 9 | 3 | 1 |
subtype4 | 0 | 4 | 8 | 2 | 6 | 10 | 1 | 0 |
subtype5 | 0 | 9 | 6 | 5 | 4 | 6 | 1 | 1 |
P value = 0.0734 (Fisher's exact test), Q value = 0.23
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 48 | 108 | 13 | 12 |
subtype1 | 17 | 22 | 1 | 0 |
subtype2 | 6 | 21 | 2 | 4 |
subtype3 | 9 | 29 | 3 | 4 |
subtype4 | 6 | 18 | 6 | 1 |
subtype5 | 10 | 18 | 1 | 3 |
P value = 0.309 (Fisher's exact test), Q value = 0.54
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 106 | 34 | 35 |
subtype1 | 27 | 7 | 3 |
subtype2 | 23 | 4 | 6 |
subtype3 | 22 | 11 | 11 |
subtype4 | 15 | 6 | 9 |
subtype5 | 19 | 6 | 6 |
P value = 0.394 (Fisher's exact test), Q value = 0.63
nPatients | 0 | 1 |
---|---|---|
ALL | 137 | 6 |
subtype1 | 31 | 2 |
subtype2 | 28 | 3 |
subtype3 | 32 | 1 |
subtype4 | 26 | 0 |
subtype5 | 20 | 0 |
P value = 0.00628 (Fisher's exact test), Q value = 0.038
nPatients | FEMALE | MALE |
---|---|---|
ALL | 105 | 76 |
subtype1 | 30 | 10 |
subtype2 | 11 | 22 |
subtype3 | 27 | 18 |
subtype4 | 16 | 15 |
subtype5 | 21 | 11 |
P value = 0.12 (Kruskal-Wallis (anova)), Q value = 0.29
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 14 | 60.0 (40.6) |
subtype1 | 3 | 50.0 (45.8) |
subtype2 | 2 | 80.0 (0.0) |
subtype3 | 2 | 0.0 (0.0) |
subtype4 | 1 | 0.0 (NA) |
subtype5 | 6 | 88.3 (9.8) |
P value = 0.0192 (Fisher's exact test), Q value = 0.082
nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | MUCINOUS (COLLOID) CARCINOMA |
---|---|---|---|---|---|---|---|---|---|
ALL | 5 | 43 | 111 | 3 | 8 | 2 | 1 | 5 | 3 |
subtype1 | 1 | 7 | 29 | 0 | 1 | 1 | 0 | 1 | 0 |
subtype2 | 0 | 17 | 13 | 1 | 1 | 0 | 0 | 1 | 0 |
subtype3 | 1 | 8 | 33 | 0 | 2 | 0 | 0 | 0 | 1 |
subtype4 | 1 | 4 | 20 | 2 | 1 | 0 | 1 | 1 | 1 |
subtype5 | 2 | 7 | 16 | 0 | 3 | 1 | 0 | 2 | 1 |
P value = 0.776 (Fisher's exact test), Q value = 0.89
nPatients | NO | YES |
---|---|---|
ALL | 13 | 168 |
subtype1 | 2 | 38 |
subtype2 | 2 | 31 |
subtype3 | 3 | 42 |
subtype4 | 4 | 27 |
subtype5 | 2 | 30 |
P value = 0.031 (Kruskal-Wallis (anova)), Q value = 0.12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 127 | 41.8 (27.1) |
subtype1 | 17 | 50.4 (28.5) |
subtype2 | 29 | 45.9 (32.3) |
subtype3 | 26 | 41.1 (21.8) |
subtype4 | 27 | 46.7 (30.8) |
subtype5 | 28 | 28.4 (15.7) |
P value = 0.00899 (Kruskal-Wallis (anova)), Q value = 0.049
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 95 | 1961.8 (12.8) |
subtype1 | 16 | 1964.8 (13.5) |
subtype2 | 22 | 1952.8 (11.9) |
subtype3 | 16 | 1963.2 (10.7) |
subtype4 | 19 | 1963.6 (12.6) |
subtype5 | 22 | 1966.0 (11.2) |
P value = 0.747 (Fisher's exact test), Q value = 0.87
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 119 | 8 | 1 | 5 |
subtype1 | 30 | 1 | 1 | 3 |
subtype2 | 28 | 1 | 0 | 1 |
subtype3 | 22 | 2 | 0 | 1 |
subtype4 | 19 | 1 | 0 | 0 |
subtype5 | 20 | 3 | 0 | 0 |
P value = 0.174 (Fisher's exact test), Q value = 0.38
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 6 | 141 |
subtype1 | 1 | 1 | 30 |
subtype2 | 0 | 3 | 22 |
subtype3 | 1 | 0 | 38 |
subtype4 | 0 | 0 | 25 |
subtype5 | 0 | 2 | 26 |
P value = 0.632 (Fisher's exact test), Q value = 0.8
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 2 | 106 |
subtype1 | 0 | 27 |
subtype2 | 0 | 11 |
subtype3 | 1 | 28 |
subtype4 | 1 | 16 |
subtype5 | 0 | 24 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 167 | 197 | 150 |
P value = 0.00333 (logrank test), Q value = 0.024
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 490 | 153 | 0.0 - 224.0 (18.1) |
subtype1 | 157 | 34 | 0.1 - 224.0 (18.8) |
subtype2 | 189 | 75 | 0.0 - 211.8 (17.6) |
subtype3 | 144 | 44 | 0.1 - 214.6 (18.3) |
P value = 0.0479 (Kruskal-Wallis (anova)), Q value = 0.16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 483 | 65.3 (10.0) |
subtype1 | 157 | 66.9 (9.3) |
subtype2 | 184 | 64.2 (10.6) |
subtype3 | 142 | 64.9 (9.6) |
P value = 0.00368 (Fisher's exact test), Q value = 0.025
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IV |
---|---|---|---|---|---|---|---|---|---|
ALL | 5 | 133 | 140 | 1 | 51 | 72 | 73 | 11 | 27 |
subtype1 | 2 | 63 | 47 | 0 | 14 | 15 | 19 | 1 | 5 |
subtype2 | 3 | 33 | 54 | 1 | 21 | 35 | 29 | 7 | 14 |
subtype3 | 0 | 37 | 39 | 0 | 16 | 22 | 25 | 3 | 8 |
P value = 0.00175 (Fisher's exact test), Q value = 0.014
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 168 | 277 | 47 | 19 |
subtype1 | 77 | 72 | 13 | 4 |
subtype2 | 49 | 117 | 19 | 10 |
subtype3 | 42 | 88 | 15 | 5 |
P value = 0.0279 (Fisher's exact test), Q value = 0.12
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 330 | 96 | 76 |
subtype1 | 119 | 25 | 17 |
subtype2 | 113 | 47 | 33 |
subtype3 | 98 | 24 | 26 |
P value = 0.447 (Fisher's exact test), Q value = 0.66
nPatients | 0 | 1 |
---|---|---|
ALL | 345 | 25 |
subtype1 | 109 | 5 |
subtype2 | 129 | 12 |
subtype3 | 107 | 8 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00036
nPatients | FEMALE | MALE |
---|---|---|
ALL | 276 | 238 |
subtype1 | 112 | 55 |
subtype2 | 113 | 84 |
subtype3 | 51 | 99 |
P value = 0.228 (Kruskal-Wallis (anova)), Q value = 0.45
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 99 | 84.6 (21.2) |
subtype1 | 30 | 84.0 (24.4) |
subtype2 | 40 | 82.0 (22.6) |
subtype3 | 29 | 89.0 (14.5) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00036
nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SIGNET RING ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) CARCINOMA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 19 | 107 | 318 | 5 | 19 | 2 | 3 | 2 | 23 | 1 | 5 | 10 |
subtype1 | 7 | 35 | 90 | 5 | 14 | 0 | 1 | 1 | 8 | 1 | 1 | 4 |
subtype2 | 3 | 34 | 146 | 0 | 3 | 2 | 2 | 0 | 4 | 0 | 3 | 0 |
subtype3 | 9 | 38 | 82 | 0 | 2 | 0 | 0 | 1 | 11 | 0 | 1 | 6 |
P value = 0.925 (Fisher's exact test), Q value = 0.99
nPatients | NO | YES |
---|---|---|
ALL | 21 | 493 |
subtype1 | 6 | 161 |
subtype2 | 8 | 189 |
subtype3 | 7 | 143 |
P value = 0.0931 (Kruskal-Wallis (anova)), Q value = 0.27
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 351 | 41.6 (27.3) |
subtype1 | 97 | 37.8 (25.7) |
subtype2 | 132 | 44.9 (27.7) |
subtype3 | 122 | 41.0 (27.9) |
P value = 0.355 (Kruskal-Wallis (anova)), Q value = 0.6
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 273 | 1965.0 (12.5) |
subtype1 | 80 | 1964.1 (10.3) |
subtype2 | 98 | 1966.3 (13.9) |
subtype3 | 95 | 1964.3 (12.7) |
P value = 0.648 (Fisher's exact test), Q value = 0.81
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 342 | 12 | 4 | 25 |
subtype1 | 112 | 3 | 1 | 11 |
subtype2 | 127 | 6 | 3 | 8 |
subtype3 | 103 | 3 | 0 | 6 |
P value = 0.972 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 8 | 51 | 387 |
subtype1 | 0 | 3 | 18 | 131 |
subtype2 | 1 | 2 | 19 | 148 |
subtype3 | 0 | 3 | 14 | 108 |
P value = 0.497 (Fisher's exact test), Q value = 0.68
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 7 | 381 |
subtype1 | 1 | 136 |
subtype2 | 4 | 147 |
subtype3 | 2 | 98 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
Number of samples | 79 | 112 | 97 | 48 | 52 | 49 | 77 |
P value = 2.5e-07 (logrank test), Q value = 4.5e-05
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 490 | 153 | 0.0 - 224.0 (18.1) |
subtype1 | 75 | 20 | 0.1 - 163.1 (17.9) |
subtype2 | 107 | 27 | 0.1 - 97.7 (18.1) |
subtype3 | 93 | 35 | 0.1 - 224.0 (19.3) |
subtype4 | 45 | 13 | 0.4 - 104.2 (20.8) |
subtype5 | 49 | 12 | 0.1 - 88.0 (15.8) |
subtype6 | 48 | 29 | 0.0 - 55.9 (14.1) |
subtype7 | 73 | 17 | 0.1 - 164.1 (20.6) |
P value = 0.000674 (Kruskal-Wallis (anova)), Q value = 0.0093
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 483 | 65.3 (10.0) |
subtype1 | 75 | 68.3 (9.2) |
subtype2 | 103 | 63.5 (10.8) |
subtype3 | 90 | 65.5 (9.7) |
subtype4 | 46 | 67.7 (7.7) |
subtype5 | 49 | 60.7 (9.6) |
subtype6 | 47 | 66.0 (9.9) |
subtype7 | 73 | 65.5 (10.2) |
P value = 0.00119 (Fisher's exact test), Q value = 0.013
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IV |
---|---|---|---|---|---|---|---|---|---|
ALL | 5 | 133 | 140 | 1 | 51 | 72 | 73 | 11 | 27 |
subtype1 | 0 | 30 | 22 | 0 | 8 | 6 | 9 | 1 | 3 |
subtype2 | 1 | 16 | 35 | 0 | 9 | 24 | 18 | 3 | 6 |
subtype3 | 3 | 26 | 27 | 1 | 14 | 7 | 11 | 2 | 6 |
subtype4 | 0 | 17 | 15 | 0 | 4 | 5 | 3 | 2 | 2 |
subtype5 | 0 | 9 | 16 | 0 | 7 | 5 | 12 | 1 | 2 |
subtype6 | 0 | 7 | 7 | 0 | 2 | 13 | 12 | 2 | 6 |
subtype7 | 1 | 28 | 18 | 0 | 7 | 12 | 8 | 0 | 2 |
P value = 0.00093 (Fisher's exact test), Q value = 0.011
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 168 | 277 | 47 | 19 |
subtype1 | 36 | 36 | 4 | 3 |
subtype2 | 24 | 69 | 13 | 5 |
subtype3 | 39 | 51 | 3 | 3 |
subtype4 | 17 | 24 | 4 | 3 |
subtype5 | 11 | 35 | 5 | 1 |
subtype6 | 8 | 29 | 8 | 3 |
subtype7 | 33 | 33 | 10 | 1 |
P value = 0.00293 (Fisher's exact test), Q value = 0.022
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 330 | 96 | 76 |
subtype1 | 57 | 12 | 9 |
subtype2 | 66 | 25 | 19 |
subtype3 | 60 | 23 | 12 |
subtype4 | 37 | 8 | 2 |
subtype5 | 36 | 3 | 12 |
subtype6 | 22 | 12 | 14 |
subtype7 | 52 | 13 | 8 |
P value = 0.513 (Fisher's exact test), Q value = 0.68
nPatients | 0 | 1 |
---|---|---|
ALL | 345 | 25 |
subtype1 | 52 | 3 |
subtype2 | 79 | 4 |
subtype3 | 55 | 6 |
subtype4 | 38 | 2 |
subtype5 | 37 | 2 |
subtype6 | 37 | 6 |
subtype7 | 47 | 2 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00036
nPatients | FEMALE | MALE |
---|---|---|
ALL | 276 | 238 |
subtype1 | 63 | 16 |
subtype2 | 59 | 53 |
subtype3 | 52 | 45 |
subtype4 | 16 | 32 |
subtype5 | 23 | 29 |
subtype6 | 19 | 30 |
subtype7 | 44 | 33 |
P value = 0.0947 (Kruskal-Wallis (anova)), Q value = 0.27
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 99 | 84.6 (21.2) |
subtype1 | 12 | 94.2 (6.7) |
subtype2 | 20 | 81.5 (24.6) |
subtype3 | 24 | 83.8 (20.4) |
subtype4 | 7 | 94.3 (7.9) |
subtype5 | 13 | 83.1 (17.5) |
subtype6 | 6 | 93.3 (10.3) |
subtype7 | 17 | 77.1 (30.0) |
P value = 0.00018 (Fisher's exact test), Q value = 0.0036
nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SIGNET RING ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) CARCINOMA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 19 | 107 | 318 | 5 | 19 | 2 | 3 | 2 | 23 | 1 | 5 | 10 |
subtype1 | 5 | 16 | 45 | 1 | 6 | 0 | 1 | 0 | 5 | 0 | 0 | 0 |
subtype2 | 2 | 19 | 80 | 0 | 3 | 1 | 2 | 0 | 4 | 0 | 1 | 0 |
subtype3 | 3 | 15 | 71 | 1 | 2 | 1 | 0 | 0 | 2 | 0 | 2 | 0 |
subtype4 | 2 | 19 | 18 | 0 | 1 | 0 | 0 | 0 | 7 | 0 | 0 | 1 |
subtype5 | 4 | 10 | 36 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
subtype6 | 1 | 12 | 31 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 2 |
subtype7 | 2 | 16 | 37 | 3 | 6 | 0 | 0 | 2 | 3 | 1 | 1 | 6 |
P value = 0.18 (Fisher's exact test), Q value = 0.38
nPatients | NO | YES |
---|---|---|
ALL | 21 | 493 |
subtype1 | 2 | 77 |
subtype2 | 4 | 108 |
subtype3 | 2 | 95 |
subtype4 | 0 | 48 |
subtype5 | 4 | 48 |
subtype6 | 4 | 45 |
subtype7 | 5 | 72 |
P value = 0.0416 (Kruskal-Wallis (anova)), Q value = 0.15
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 351 | 41.6 (27.3) |
subtype1 | 46 | 35.4 (25.7) |
subtype2 | 78 | 41.1 (25.7) |
subtype3 | 64 | 49.9 (31.5) |
subtype4 | 37 | 40.4 (30.5) |
subtype5 | 42 | 37.3 (26.3) |
subtype6 | 39 | 45.9 (24.1) |
subtype7 | 45 | 38.2 (24.2) |
P value = 0.000498 (Kruskal-Wallis (anova)), Q value = 0.0075
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 273 | 1965.0 (12.5) |
subtype1 | 37 | 1963.0 (10.3) |
subtype2 | 59 | 1967.5 (14.2) |
subtype3 | 50 | 1963.5 (12.3) |
subtype4 | 29 | 1956.9 (11.4) |
subtype5 | 34 | 1970.3 (9.7) |
subtype6 | 29 | 1965.1 (13.3) |
subtype7 | 35 | 1966.2 (11.2) |
P value = 0.243 (Fisher's exact test), Q value = 0.46
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 342 | 12 | 4 | 25 |
subtype1 | 54 | 4 | 0 | 2 |
subtype2 | 77 | 1 | 2 | 3 |
subtype3 | 58 | 3 | 2 | 9 |
subtype4 | 28 | 0 | 0 | 3 |
subtype5 | 37 | 1 | 0 | 2 |
subtype6 | 35 | 3 | 0 | 2 |
subtype7 | 53 | 0 | 0 | 4 |
P value = 0.6 (Fisher's exact test), Q value = 0.77
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 8 | 51 | 387 |
subtype1 | 0 | 2 | 6 | 62 |
subtype2 | 1 | 3 | 9 | 84 |
subtype3 | 0 | 1 | 14 | 70 |
subtype4 | 0 | 0 | 5 | 37 |
subtype5 | 0 | 0 | 5 | 38 |
subtype6 | 0 | 2 | 2 | 38 |
subtype7 | 0 | 0 | 10 | 58 |
P value = 0.0351 (Fisher's exact test), Q value = 0.13
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 7 | 381 |
subtype1 | 1 | 60 |
subtype2 | 0 | 85 |
subtype3 | 4 | 71 |
subtype4 | 0 | 34 |
subtype5 | 0 | 36 |
subtype6 | 2 | 31 |
subtype7 | 0 | 64 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 190 | 227 | 95 |
P value = 0.178 (logrank test), Q value = 0.38
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 488 | 152 | 0.0 - 224.0 (18.4) |
subtype1 | 180 | 48 | 0.1 - 164.1 (18.4) |
subtype2 | 219 | 70 | 0.0 - 214.6 (19.0) |
subtype3 | 89 | 34 | 0.1 - 224.0 (16.4) |
P value = 0.0102 (Kruskal-Wallis (anova)), Q value = 0.051
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 482 | 65.3 (10.0) |
subtype1 | 180 | 67.0 (9.4) |
subtype2 | 217 | 64.0 (10.3) |
subtype3 | 85 | 65.1 (9.7) |
P value = 0.00131 (Fisher's exact test), Q value = 0.013
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IV |
---|---|---|---|---|---|---|---|---|---|
ALL | 5 | 134 | 140 | 1 | 51 | 71 | 73 | 11 | 25 |
subtype1 | 1 | 72 | 40 | 0 | 19 | 25 | 22 | 1 | 9 |
subtype2 | 4 | 46 | 70 | 0 | 22 | 34 | 30 | 8 | 13 |
subtype3 | 0 | 16 | 30 | 1 | 10 | 12 | 21 | 2 | 3 |
P value = 0.0172 (Fisher's exact test), Q value = 0.079
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 169 | 274 | 47 | 19 |
subtype1 | 83 | 85 | 16 | 6 |
subtype2 | 60 | 133 | 23 | 9 |
subtype3 | 26 | 56 | 8 | 4 |
P value = 0.276 (Fisher's exact test), Q value = 0.49
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 329 | 95 | 76 |
subtype1 | 124 | 39 | 21 |
subtype2 | 149 | 38 | 36 |
subtype3 | 56 | 18 | 19 |
P value = 0.55 (Fisher's exact test), Q value = 0.72
nPatients | 0 | 1 |
---|---|---|
ALL | 345 | 23 |
subtype1 | 130 | 8 |
subtype2 | 156 | 13 |
subtype3 | 59 | 2 |
P value = 0.476 (Fisher's exact test), Q value = 0.68
nPatients | FEMALE | MALE |
---|---|---|
ALL | 273 | 239 |
subtype1 | 108 | 82 |
subtype2 | 116 | 111 |
subtype3 | 49 | 46 |
P value = 0.685 (Kruskal-Wallis (anova)), Q value = 0.82
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 97 | 84.3 (21.3) |
subtype1 | 31 | 83.9 (23.8) |
subtype2 | 54 | 85.0 (20.9) |
subtype3 | 12 | 82.5 (17.1) |
P value = 0.00075 (Fisher's exact test), Q value = 0.0096
nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SIGNET RING ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) CARCINOMA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 19 | 106 | 318 | 5 | 19 | 2 | 2 | 2 | 23 | 1 | 5 | 10 |
subtype1 | 10 | 45 | 99 | 4 | 12 | 1 | 1 | 2 | 8 | 1 | 2 | 5 |
subtype2 | 8 | 53 | 147 | 0 | 4 | 1 | 0 | 0 | 9 | 0 | 3 | 2 |
subtype3 | 1 | 8 | 72 | 1 | 3 | 0 | 1 | 0 | 6 | 0 | 0 | 3 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 20 | 492 |
subtype1 | 7 | 183 |
subtype2 | 9 | 218 |
subtype3 | 4 | 91 |
P value = 0.0797 (Kruskal-Wallis (anova)), Q value = 0.24
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 351 | 41.8 (27.4) |
subtype1 | 125 | 38.2 (25.8) |
subtype2 | 168 | 43.2 (27.9) |
subtype3 | 58 | 45.3 (28.8) |
P value = 0.017 (Kruskal-Wallis (anova)), Q value = 0.079
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 273 | 1964.8 (12.5) |
subtype1 | 104 | 1962.3 (11.9) |
subtype2 | 129 | 1967.1 (12.7) |
subtype3 | 40 | 1963.5 (12.1) |
P value = 0.451 (Fisher's exact test), Q value = 0.66
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 339 | 12 | 4 | 26 |
subtype1 | 122 | 2 | 2 | 10 |
subtype2 | 162 | 7 | 2 | 9 |
subtype3 | 55 | 3 | 0 | 7 |
P value = 0.441 (Fisher's exact test), Q value = 0.66
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 8 | 51 | 386 |
subtype1 | 1 | 18 | 152 |
subtype2 | 5 | 25 | 158 |
subtype3 | 2 | 8 | 76 |
P value = 0.366 (Fisher's exact test), Q value = 0.6
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 7 | 379 |
subtype1 | 1 | 144 |
subtype2 | 5 | 161 |
subtype3 | 1 | 74 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 72 | 198 | 142 | 100 |
P value = 0.817 (logrank test), Q value = 0.92
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 488 | 152 | 0.0 - 224.0 (18.4) |
subtype1 | 69 | 20 | 0.1 - 107.2 (20.6) |
subtype2 | 191 | 58 | 0.0 - 224.0 (15.7) |
subtype3 | 133 | 41 | 0.1 - 164.1 (17.5) |
subtype4 | 95 | 33 | 0.1 - 214.6 (20.2) |
P value = 0.00155 (Kruskal-Wallis (anova)), Q value = 0.013
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 482 | 65.3 (10.0) |
subtype1 | 68 | 68.1 (7.8) |
subtype2 | 188 | 63.7 (10.0) |
subtype3 | 133 | 66.9 (9.8) |
subtype4 | 93 | 64.1 (10.8) |
P value = 0.59 (Fisher's exact test), Q value = 0.76
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IV |
---|---|---|---|---|---|---|---|---|---|
ALL | 5 | 134 | 140 | 1 | 51 | 71 | 73 | 11 | 25 |
subtype1 | 0 | 29 | 16 | 0 | 3 | 10 | 10 | 1 | 3 |
subtype2 | 3 | 39 | 61 | 0 | 20 | 30 | 30 | 6 | 9 |
subtype3 | 1 | 42 | 36 | 1 | 16 | 19 | 16 | 2 | 8 |
subtype4 | 1 | 24 | 27 | 0 | 12 | 12 | 17 | 2 | 5 |
P value = 0.135 (Fisher's exact test), Q value = 0.32
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 169 | 274 | 47 | 19 |
subtype1 | 31 | 33 | 4 | 4 |
subtype2 | 50 | 120 | 19 | 8 |
subtype3 | 55 | 67 | 14 | 4 |
subtype4 | 33 | 54 | 10 | 3 |
P value = 0.716 (Fisher's exact test), Q value = 0.84
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 329 | 95 | 76 |
subtype1 | 48 | 14 | 7 |
subtype2 | 128 | 36 | 32 |
subtype3 | 89 | 29 | 18 |
subtype4 | 64 | 16 | 19 |
P value = 0.846 (Fisher's exact test), Q value = 0.95
nPatients | 0 | 1 |
---|---|---|
ALL | 345 | 23 |
subtype1 | 50 | 2 |
subtype2 | 144 | 9 |
subtype3 | 89 | 7 |
subtype4 | 62 | 5 |
P value = 0.0046 (Fisher's exact test), Q value = 0.03
nPatients | FEMALE | MALE |
---|---|---|
ALL | 273 | 239 |
subtype1 | 35 | 37 |
subtype2 | 113 | 85 |
subtype3 | 86 | 56 |
subtype4 | 39 | 61 |
P value = 0.715 (Kruskal-Wallis (anova)), Q value = 0.84
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 97 | 84.3 (21.3) |
subtype1 | 8 | 90.0 (7.6) |
subtype2 | 46 | 85.0 (22.3) |
subtype3 | 21 | 80.5 (27.8) |
subtype4 | 22 | 84.5 (14.7) |
P value = 0.00133 (Fisher's exact test), Q value = 0.013
nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SIGNET RING ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) CARCINOMA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 19 | 106 | 318 | 5 | 19 | 2 | 2 | 2 | 23 | 1 | 5 | 10 |
subtype1 | 6 | 18 | 39 | 0 | 4 | 1 | 0 | 0 | 4 | 0 | 0 | 0 |
subtype2 | 4 | 40 | 135 | 2 | 4 | 0 | 2 | 0 | 10 | 0 | 1 | 0 |
subtype3 | 6 | 30 | 73 | 3 | 10 | 0 | 0 | 2 | 7 | 1 | 2 | 8 |
subtype4 | 3 | 18 | 71 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 2 | 2 |
P value = 0.782 (Fisher's exact test), Q value = 0.89
nPatients | NO | YES |
---|---|---|
ALL | 20 | 492 |
subtype1 | 4 | 68 |
subtype2 | 8 | 190 |
subtype3 | 4 | 138 |
subtype4 | 4 | 96 |
P value = 0.0407 (Kruskal-Wallis (anova)), Q value = 0.15
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 351 | 41.8 (27.4) |
subtype1 | 49 | 43.3 (29.9) |
subtype2 | 136 | 41.4 (25.3) |
subtype3 | 92 | 36.2 (24.3) |
subtype4 | 74 | 48.4 (31.5) |
P value = 0.00525 (Kruskal-Wallis (anova)), Q value = 0.033
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 273 | 1964.8 (12.5) |
subtype1 | 47 | 1959.6 (12.7) |
subtype2 | 102 | 1966.3 (12.0) |
subtype3 | 71 | 1964.1 (11.7) |
subtype4 | 53 | 1967.2 (13.1) |
P value = 0.954 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 339 | 12 | 4 | 26 |
subtype1 | 41 | 1 | 0 | 4 |
subtype2 | 140 | 6 | 1 | 8 |
subtype3 | 90 | 3 | 2 | 9 |
subtype4 | 68 | 2 | 1 | 5 |
P value = 0.316 (Fisher's exact test), Q value = 0.55
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 8 | 51 | 386 |
subtype1 | 1 | 6 | 58 |
subtype2 | 4 | 18 | 150 |
subtype3 | 2 | 11 | 114 |
subtype4 | 1 | 16 | 64 |
P value = 0.757 (Fisher's exact test), Q value = 0.87
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 7 | 379 |
subtype1 | 0 | 52 |
subtype2 | 3 | 149 |
subtype3 | 2 | 108 |
subtype4 | 2 | 70 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 146 | 197 | 93 |
P value = 0.267 (logrank test), Q value = 0.49
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 414 | 127 | 0.1 - 224.0 (17.6) |
subtype1 | 137 | 47 | 0.1 - 163.1 (17.6) |
subtype2 | 190 | 52 | 0.1 - 214.6 (17.9) |
subtype3 | 87 | 28 | 0.1 - 224.0 (15.8) |
P value = 0.657 (Kruskal-Wallis (anova)), Q value = 0.82
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 408 | 65.1 (10.0) |
subtype1 | 137 | 65.4 (10.7) |
subtype2 | 188 | 64.7 (9.7) |
subtype3 | 83 | 65.4 (9.9) |
P value = 0.476 (Fisher's exact test), Q value = 0.68
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IV |
---|---|---|---|---|---|---|---|---|---|
ALL | 5 | 113 | 114 | 1 | 48 | 61 | 64 | 8 | 21 |
subtype1 | 1 | 36 | 33 | 0 | 18 | 19 | 24 | 4 | 10 |
subtype2 | 4 | 58 | 52 | 1 | 23 | 26 | 22 | 3 | 8 |
subtype3 | 0 | 19 | 29 | 0 | 7 | 16 | 18 | 1 | 3 |
P value = 0.015 (Fisher's exact test), Q value = 0.073
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 147 | 231 | 40 | 15 |
subtype1 | 48 | 73 | 14 | 11 |
subtype2 | 76 | 100 | 18 | 2 |
subtype3 | 23 | 58 | 8 | 2 |
P value = 0.191 (Fisher's exact test), Q value = 0.4
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 280 | 81 | 65 |
subtype1 | 86 | 34 | 21 |
subtype2 | 138 | 31 | 26 |
subtype3 | 56 | 16 | 18 |
P value = 0.434 (Fisher's exact test), Q value = 0.66
nPatients | 0 | 1 |
---|---|---|
ALL | 279 | 19 |
subtype1 | 97 | 9 |
subtype2 | 123 | 8 |
subtype3 | 59 | 2 |
P value = 0.96 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 233 | 203 |
subtype1 | 77 | 69 |
subtype2 | 105 | 92 |
subtype3 | 51 | 42 |
P value = 0.109 (Kruskal-Wallis (anova)), Q value = 0.28
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 90 | 85.0 (20.1) |
subtype1 | 17 | 75.3 (30.2) |
subtype2 | 56 | 87.9 (16.8) |
subtype3 | 17 | 85.3 (15.0) |
P value = 5e-05 (Fisher's exact test), Q value = 0.0013
nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SIGNET RING ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) CARCINOMA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 17 | 86 | 266 | 5 | 19 | 1 | 2 | 2 | 22 | 1 | 5 | 10 |
subtype1 | 4 | 38 | 75 | 3 | 11 | 1 | 2 | 1 | 7 | 0 | 0 | 4 |
subtype2 | 13 | 39 | 117 | 0 | 7 | 0 | 0 | 0 | 11 | 1 | 5 | 4 |
subtype3 | 0 | 9 | 74 | 2 | 1 | 0 | 0 | 1 | 4 | 0 | 0 | 2 |
P value = 0.0325 (Fisher's exact test), Q value = 0.13
nPatients | NO | YES |
---|---|---|
ALL | 18 | 418 |
subtype1 | 9 | 137 |
subtype2 | 3 | 194 |
subtype3 | 6 | 87 |
P value = 0.00889 (Kruskal-Wallis (anova)), Q value = 0.049
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 296 | 41.3 (27.5) |
subtype1 | 104 | 36.2 (26.9) |
subtype2 | 139 | 43.8 (28.0) |
subtype3 | 53 | 44.9 (26.3) |
P value = 0.506 (Kruskal-Wallis (anova)), Q value = 0.68
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 235 | 1965.0 (12.3) |
subtype1 | 77 | 1964.6 (13.2) |
subtype2 | 121 | 1966.0 (11.8) |
subtype3 | 37 | 1962.8 (11.9) |
P value = 0.158 (Fisher's exact test), Q value = 0.36
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 279 | 9 | 1 | 22 |
subtype1 | 83 | 5 | 1 | 4 |
subtype2 | 139 | 2 | 0 | 15 |
subtype3 | 57 | 2 | 0 | 3 |
P value = 0.95 (Fisher's exact test), Q value = 1
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 5 | 49 | 332 |
subtype1 | 1 | 15 | 110 |
subtype2 | 3 | 24 | 148 |
subtype3 | 1 | 10 | 74 |
P value = 0.102 (Fisher's exact test), Q value = 0.27
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 6 | 324 |
subtype1 | 4 | 91 |
subtype2 | 2 | 159 |
subtype3 | 0 | 74 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 103 | 247 | 86 |
P value = 0.0545 (logrank test), Q value = 0.18
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 414 | 127 | 0.1 - 224.0 (17.6) |
subtype1 | 99 | 20 | 0.1 - 164.1 (19.0) |
subtype2 | 233 | 77 | 0.1 - 214.6 (15.8) |
subtype3 | 82 | 30 | 0.1 - 224.0 (17.4) |
P value = 2.92e-06 (Kruskal-Wallis (anova)), Q value = 0.00026
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 408 | 65.1 (10.0) |
subtype1 | 98 | 68.3 (8.1) |
subtype2 | 229 | 62.9 (10.4) |
subtype3 | 81 | 67.2 (9.7) |
P value = 0.398 (Fisher's exact test), Q value = 0.63
nPatients | STAGE I | STAGE IA | STAGE IB | STAGE II | STAGE IIA | STAGE IIB | STAGE IIIA | STAGE IIIB | STAGE IV |
---|---|---|---|---|---|---|---|---|---|
ALL | 5 | 113 | 114 | 1 | 48 | 61 | 64 | 8 | 21 |
subtype1 | 1 | 35 | 22 | 1 | 10 | 16 | 9 | 2 | 6 |
subtype2 | 4 | 54 | 68 | 0 | 30 | 37 | 39 | 4 | 11 |
subtype3 | 0 | 24 | 24 | 0 | 8 | 8 | 16 | 2 | 4 |
P value = 0.00931 (Fisher's exact test), Q value = 0.049
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 147 | 231 | 40 | 15 |
subtype1 | 43 | 42 | 13 | 4 |
subtype2 | 74 | 143 | 24 | 5 |
subtype3 | 30 | 46 | 3 | 6 |
P value = 0.0695 (Fisher's exact test), Q value = 0.22
nPatients | N0 | N1 | N2+N3 |
---|---|---|---|
ALL | 280 | 81 | 65 |
subtype1 | 75 | 15 | 8 |
subtype2 | 155 | 46 | 43 |
subtype3 | 50 | 20 | 14 |
P value = 0.582 (Fisher's exact test), Q value = 0.75
nPatients | 0 | 1 |
---|---|---|
ALL | 279 | 19 |
subtype1 | 66 | 6 |
subtype2 | 160 | 11 |
subtype3 | 53 | 2 |
P value = 0.00045 (Fisher's exact test), Q value = 0.0074
nPatients | FEMALE | MALE |
---|---|---|
ALL | 233 | 203 |
subtype1 | 52 | 51 |
subtype2 | 119 | 128 |
subtype3 | 62 | 24 |
P value = 0.668 (Kruskal-Wallis (anova)), Q value = 0.82
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 90 | 85.0 (20.1) |
subtype1 | 17 | 90.6 (6.6) |
subtype2 | 59 | 84.4 (20.0) |
subtype3 | 14 | 80.7 (29.2) |
P value = 7e-05 (Fisher's exact test), Q value = 0.0016
nPatients | LUNG ACINAR ADENOCARCINOMA | LUNG ADENOCARCINOMA MIXED SUBTYPE | LUNG ADENOCARCINOMA- NOT OTHERWISE SPECIFIED (NOS) | LUNG BRONCHIOLOALVEOLAR CARCINOMA MUCINOUS | LUNG BRONCHIOLOALVEOLAR CARCINOMA NONMUCINOUS | LUNG CLEAR CELL ADENOCARCINOMA | LUNG MICROPAPILLARY ADENOCARCINOMA | LUNG MUCINOUS ADENOCARCINOMA | LUNG PAPILLARY ADENOCARCINOMA | LUNG SIGNET RING ADENOCARCINOMA | LUNG SOLID PATTERN PREDOMINANT ADENOCARCINOMA | MUCINOUS (COLLOID) CARCINOMA |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 17 | 86 | 266 | 5 | 19 | 1 | 2 | 2 | 22 | 1 | 5 | 10 |
subtype1 | 5 | 27 | 43 | 3 | 6 | 0 | 0 | 2 | 8 | 1 | 1 | 7 |
subtype2 | 9 | 44 | 168 | 0 | 8 | 1 | 0 | 0 | 10 | 0 | 4 | 3 |
subtype3 | 3 | 15 | 55 | 2 | 5 | 0 | 2 | 0 | 4 | 0 | 0 | 0 |
P value = 0.0923 (Fisher's exact test), Q value = 0.27
nPatients | NO | YES |
---|---|---|
ALL | 18 | 418 |
subtype1 | 1 | 102 |
subtype2 | 11 | 236 |
subtype3 | 6 | 80 |
P value = 0.224 (Kruskal-Wallis (anova)), Q value = 0.44
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 296 | 41.3 (27.5) |
subtype1 | 67 | 39.6 (29.0) |
subtype2 | 176 | 43.1 (27.8) |
subtype3 | 53 | 37.6 (24.5) |
P value = 0.00232 (Kruskal-Wallis (anova)), Q value = 0.018
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 235 | 1965.0 (12.3) |
subtype1 | 53 | 1961.2 (10.6) |
subtype2 | 138 | 1967.3 (12.1) |
subtype3 | 44 | 1962.6 (13.5) |
P value = 0.0999 (Fisher's exact test), Q value = 0.27
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 279 | 9 | 1 | 22 |
subtype1 | 65 | 0 | 0 | 9 |
subtype2 | 164 | 5 | 1 | 10 |
subtype3 | 50 | 4 | 0 | 3 |
P value = 0.103 (Fisher's exact test), Q value = 0.27
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 5 | 49 | 332 |
subtype1 | 2 | 9 | 81 |
subtype2 | 1 | 34 | 181 |
subtype3 | 2 | 6 | 70 |
P value = 0.454 (Fisher's exact test), Q value = 0.66
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 6 | 324 |
subtype1 | 0 | 82 |
subtype2 | 5 | 182 |
subtype3 | 1 | 60 |
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Cluster data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_mergedClustering/LUAD-TP/15111023/LUAD-TP.mergedcluster.txt
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Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/LUAD-TP/15084450/LUAD-TP.merged_data.txt
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Number of patients = 518
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Number of clustering approaches = 12
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Number of selected clinical features = 15
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Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.