E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.006 0.071 -9999.0 0.0 -0.31 24.0 24.0 KLHL20 -0.003 0.051 0.159 1.0 -0.205 13.0 14.0 CYFIP2 0.016 0.04 -9999.0 0.0 -0.325 7.0 7.0 Rac1/GDP -0.011 0.061 0.328 3.0 -0.251 9.0 12.0 ENAH -0.006 0.071 -9999.0 0.0 -0.313 24.0 24.0 AP1M1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.026 0.023 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.027 -9999.0 0.0 -0.142 14.0 14.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.046 0.026 -9999.0 0.0 -0.175 3.0 3.0 RAPGEF1 -0.01 0.06 0.213 2.0 -0.314 9.0 11.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.004 0.075 -9999.0 0.0 -0.317 25.0 25.0 CRK -0.01 0.054 -9999.0 0.0 -0.302 15.0 15.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.019 -9999.0 0.0 -0.195 2.0 2.0 alphaE/beta7 Integrin 0.028 0.015 -9999.0 0.0 -0.229 1.0 1.0 IQGAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.004 0.068 -9999.0 0.0 -0.314 22.0 22.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.026 0.016 -9999.0 0.0 -0.132 2.0 2.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.047 0.053 0.212 38.0 -0.162 6.0 44.0 PI3K -0.031 0.02 -9999.0 0.0 -0.166 2.0 2.0 ARF6 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.029 0.018 -9999.0 0.0 -0.228 2.0 2.0 TIAM1 0.015 0.04 -9999.0 0.0 -0.325 7.0 7.0 E-cadherin(dimer)/Ca2+ 0.045 0.02 -9999.0 0.0 -0.16 2.0 2.0 AKT1 -0.017 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.02 0.016 -9999.0 0.0 -0.325 1.0 1.0 CDH1 0.019 0.022 -9999.0 0.0 -0.325 2.0 2.0 RhoA/GDP -0.011 0.064 0.283 5.0 -0.25 8.0 13.0 actin cytoskeleton organization 0.001 0.045 0.166 9.0 -0.155 11.0 20.0 CDC42/GDP -0.012 0.064 0.283 5.0 -0.256 9.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.009 0.013 -9999.0 0.0 -0.188 2.0 2.0 ITGB7 0.02 0.016 -9999.0 0.0 -0.325 1.0 1.0 RAC1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.021 -9999.0 0.0 -0.171 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.016 -9999.0 0.0 -0.154 2.0 2.0 mol:GDP -0.012 0.07 0.293 5.0 -0.286 10.0 15.0 CDC42/GTP/IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.005 0.061 0.217 3.0 -0.257 5.0 8.0 RAC1/GTP/IQGAP1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.003 0.039 0.145 12.0 -0.136 7.0 19.0 NME1 0.046 0.084 0.324 43.0 -9999.0 0.0 43.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.001 0.056 -9999.0 0.0 -0.311 14.0 14.0 regulation of cell-cell adhesion -0.024 0.019 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.004 0.023 -9999.0 0.0 -0.093 1.0 1.0 Rap1/GTP -0.023 0.03 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.031 -9999.0 0.0 -0.175 3.0 3.0 CCND1 0.002 0.042 0.146 10.0 -0.158 9.0 19.0 VAV2 -0.01 0.128 -9999.0 0.0 -0.568 20.0 20.0 RAP1/GDP -0.02 0.045 0.194 1.0 -0.227 4.0 5.0 adherens junction assembly 0.0 0.055 -9999.0 0.0 -0.302 14.0 14.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.036 0.027 -9999.0 0.0 -0.173 2.0 2.0 E-cadherin/beta catenin 0.004 0.019 -9999.0 0.0 -0.277 2.0 2.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.006 0.071 -9999.0 0.0 -0.311 24.0 24.0 PIK3CA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.007 0.066 -9999.0 0.0 -0.327 15.0 15.0 E-cadherin/beta catenin/alpha catenin 0.039 0.019 -9999.0 0.0 -0.184 2.0 2.0 ITGAE 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.001 0.075 -9999.0 0.0 -0.323 25.0 25.0