Clinical Features MRNA_CNMF MRNA_CHIERARCHICAL CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q TP53 141 (79%) 37 0.04456 0.335 0.02606 0.253 0.00056999 0.0194 0.00155 0.0339 1 1 0.70029 1 0.0052399 0.0972 0.02279 0.253 0.40887 0.959 0.43945 0.968 0.091949 0.478 0.063039 0.402 NFE2L2 27 (15%) 151 0.00025 0.0102 0.00021 0.0102 0.01434 0.183 0.04753 0.335 0.25248 0.844 0.73796 1 2e-05 0.00204 9.9999e-06 0.00204 0.0064899 0.102 5e-05 0.0034 0.63108 1 0.86257 1 CDKN2A 26 (15%) 152 0.00126 0.0321 0.0059599 0.101 0.02509 0.253 0.54243 0.988 0.33956 0.913 0.16998 0.694 0.37928 0.918 0.090649 0.478 0.66229 1 0.81693 1 0.84315 1 0.02981 0.253 KEAP1 22 (12%) 156 0.00166 0.0339 0.00068999 0.0201 0.11884 0.551 0.062449 0.402 0.20535 0.748 0.1486 0.644 0.18757 0.709 0.02803 0.253 0.18337 0.709 0.44493 0.968 0.47789 0.968 0.66937 1 PTEN 14 (8%) 164 0.38238 0.918 0.32418 0.913 0.41448 0.961 0.15143 0.644 0.72357 1 0.96014 1 0.59457 0.999 0.51489 0.981 0.57254 0.99 0.51157 0.981 0.20012 0.742 1 1 PIK3CA 27 (15%) 151 0.69062 1 0.75411 1 0.29441 0.913 0.91927 1 1 1 0.66563 1 0.3433 0.913 0.58539 0.999 0.36464 0.913 0.37525 0.918 0.72262 1 0.75471 1 MLL2 35 (20%) 143 0.16878 0.694 0.46703 0.968 0.64484 1 0.42319 0.968 0.69604 1 0.36278 0.913 0.32341 0.913 0.85715 1 0.93049 1 0.94077 1 0.74431 1 1 1 RB1 12 (7%) 166 0.31652 0.913 0.64578 1 0.52195 0.981 0.12711 0.576 0.6547 1 0.48161 0.968 0.77471 1 0.23933 0.837 0.32218 0.913 0.7513 1 NA NA NA NA IBTK 5 (3%) 173 0.49327 0.968 0.84858 1 0.73744 1 NA NA NA NA NA NA 0.80719 1 0.84308 1 1 1 0.61117 1 NA NA NA NA CYP11B1 15 (8%) 163 0.65307 1 0.68169 1 0.65857 1 0.34684 0.913 0.24207 0.837 0.093799 0.478 0.56992 0.99 0.3668 0.913 0.56184 0.99 0.97722 1 NA NA NA NA NOTCH1 14 (8%) 164 0.81748 1 0.60215 0.999 0.46918 0.968 0.04903 0.335 0.58912 0.999 0.62973 1 0.75733 1 0.39232 0.931 0.351 0.913 0.31907 0.913 0.0093999 0.137 0.02979 0.253 SLC28A1 9 (5%) 169 0.01371 0.183 0.04928 0.335 0.081539 0.465 0.099129 0.493 0.32073 0.913 0.5261 0.981 0.03849 0.302 0.02782 0.253 0.18594 0.709 0.01815 0.218 0.81598 1 0.18255 0.709 ASB5 9 (5%) 169 0.49304 0.968 0.55192 0.99 0.25831 0.85 NA NA 0.47393 0.968 1 1 0.48194 0.968 0.49313 0.968 0.2522 0.844 0.33508 0.913 NA NA NA NA CPS1 25 (14%) 153 0.76601 1 0.23517 0.837 0.27207 0.881 1 1 0.7318 1 0.4983 0.968 0.9902 1 0.72104 1 0.0374 0.302 0.27783 0.886 1 1 1 1 EP300 8 (4%) 170 0.14982 0.644 0.11635 0.551 0.4371 0.968 NA NA 0.35885 0.913 1 1 0.082929 0.465 0.084359 0.465 0.5651 0.99 0.82153 1 NA NA NA NA ARID1A 12 (7%) 166 0.31207 0.913 0.55352 0.99 0.45337 0.968 0.34637 0.913 0.49593 0.968 0.59986 0.999 0.10799 0.525 0.86062 1 0.53408 0.982 0.69345 1 NA NA NA NA FBXW7 10 (6%) 168 0.49131 0.968 0.82657 1 0.071059 0.426 NA NA 0.6207 1 0.7891 1 0.83432 1 0.52875 0.981 0.96118 1 0.065749 0.406 NA NA NA NA