Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.432 0.294 -9999.0 0.0 -0.693 233.0 233.0 IHH -0.466 0.383 -9999.0 0.0 -0.808 278.0 278.0 SHH Np/Cholesterol/GAS1 -0.069 0.164 -9999.0 0.0 -0.453 72.0 72.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.068 0.162 0.45 72.0 -9999.0 0.0 72.0 SMO/beta Arrestin2 -0.359 0.249 -9999.0 0.0 -0.591 240.0 240.0 SMO -0.379 0.27 -9999.0 0.0 -0.6 282.0 282.0 AKT1 -0.15 0.109 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.004 0.049 -9999.0 0.0 -0.629 3.0 3.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.372 0.265 -9999.0 0.0 -0.588 283.0 283.0 STIL -0.325 0.245 -9999.0 0.0 -0.525 258.0 258.0 DHH N/PTCH2 -0.046 0.155 -9999.0 0.0 -0.56 41.0 41.0 DHH N/PTCH1 -0.363 0.244 -9999.0 0.0 -0.575 246.0 246.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.053 0.19 -9999.0 0.0 -0.737 36.0 36.0 PTHLH -0.583 0.355 -9999.0 0.0 -0.92 233.0 233.0 determination of left/right symmetry -0.372 0.265 -9999.0 0.0 -0.588 283.0 283.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.576 0.348 -9999.0 0.0 -0.906 233.0 233.0 IHH N/Hhip -0.644 0.377 -9999.0 0.0 -0.813 396.0 396.0 DHH N/Hhip -0.401 0.295 -9999.0 0.0 -0.593 339.0 339.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.372 0.265 -9999.0 0.0 -0.588 283.0 283.0 pancreas development -0.485 0.349 -9999.0 0.0 -0.736 330.0 330.0 HHAT 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.013 0.098 -9999.0 0.0 -0.737 9.0 9.0 somite specification -0.372 0.265 -9999.0 0.0 -0.588 283.0 283.0 SHH Np/Cholesterol/PTCH1 -0.347 0.249 -9999.0 0.0 -0.553 256.0 256.0 SHH Np/Cholesterol/PTCH2 -0.066 0.156 -9999.0 0.0 -0.429 77.0 77.0 SHH Np/Cholesterol/Megalin -0.279 0.265 -9999.0 0.0 -0.492 284.0 284.0 SHH -0.062 0.198 -9999.0 0.0 -0.543 72.0 72.0 catabolic process -0.37 0.251 -9999.0 0.0 -0.568 288.0 288.0 SMO/Vitamin D3 -0.368 0.263 -9999.0 0.0 -0.589 255.0 255.0 SHH Np/Cholesterol/Hhip -0.348 0.257 -9999.0 0.0 -0.497 351.0 351.0 LRP2 -0.368 0.369 -9999.0 0.0 -0.737 250.0 250.0 receptor-mediated endocytosis -0.491 0.309 -9999.0 0.0 -0.71 289.0 289.0 SHH Np/Cholesterol/BOC -0.063 0.153 -9999.0 0.0 -0.428 74.0 74.0 SHH Np/Cholesterol/CDO -0.066 0.155 -9999.0 0.0 -0.427 77.0 77.0 mesenchymal cell differentiation 0.345 0.255 0.493 351.0 -9999.0 0.0 351.0 mol:Vitamin D3 -0.346 0.258 -9999.0 0.0 -0.559 256.0 256.0 IHH N/PTCH2 -0.303 0.267 -9999.0 0.0 -0.537 278.0 278.0 CDON -0.007 0.073 -9999.0 0.0 -0.737 5.0 5.0 IHH N/PTCH1 -0.375 0.255 -9999.0 0.0 -0.577 288.0 288.0 Megalin/LRPAP1 -0.277 0.278 -9999.0 0.0 -0.556 250.0 250.0 PTCH2 -0.008 0.075 -9999.0 0.0 -0.683 6.0 6.0 SHH Np/Cholesterol -0.062 0.153 -9999.0 0.0 -0.433 72.0 72.0 PTCH1 -0.372 0.252 -9999.0 0.0 -0.571 288.0 288.0 HHIP -0.486 0.35 -9999.0 0.0 -0.737 330.0 330.0